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  1. Ridaforolimus is a mammalian target of rapamycin inhibitor that has activity in solid tumors. Paclitaxel and carboplatin have broad antineoplastic activity in many cancers. This phase I trial was conducted to ...

    Authors: Hye Sook Chon, Sokbom Kang, Jae K. Lee, Sachin M. Apte, Mian M. Shahzad, Irene Williams-Elson and Robert M. Wenham
    Citation: BMC Cancer 2017 17:407
    Content type: Research article Published on:

  2. The prognostic significance of free cancer cells detected in peritoneal fluid at the time of rectal surgery remains unclear. A substantial number of patients will develop metastatic disease even with successfu...

    Authors: Christian Arstad, Paulo Refinetti, Annette Torgunrud Kristensen, Karl-Erik Giercksky and Per Olaf Ekstrøm
    Citation: BMC Cancer 2017 17:406
    Content type: Research article Published on:

  3. Doxorubicin (DXR) hydrochloride (HCl) liposome injection is an important part of the treatment armamentarium for a number of cancers. With growing needs for affordable and effective anticancer treatments, the ...

    Authors: Vinod Burade, Subhas Bhowmick, Kuntal Maiti, Rishit Zalawadia, Harry Ruan and Rajamannar Thennati
    Citation: BMC Cancer 2017 17:405
    Content type: Research article Published on:

  4. Inflammation is widely recognized to play an important role in cancer progression, and the peripheral monocyte count has been reported to correlate with the prognosis in patients with colorectal cancer. This i...

    Authors: Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Shigetomi Nakao, Shinji Matsutani, Kosei Hirakawa and Masaichi Ohira
    Citation: BMC Cancer 2017 17:404
    Content type: Research article Published on:

  6. Primary objective was to describe the proportion of children newly diagnosed with cancer enrolled on a therapeutic clinical trial. Secondary objectives were to describe reasons for non-enrollment and factors a...

    Authors: Jason D. Pole, Randy Barber, Rose-Émilie Bergeron, Anne Sophie Carret, David Dix, Ketan Kulkarni, Emilie Martineau, Alicia Randall, David Stammers, Caron Strahlendorf, Douglas R. Strother, Tony H. Truong and Lillian Sung
    Citation: BMC Cancer 2017 17:402
    Content type: Research article Published on:

  7. Neoadjuvant therapy is increasingly the standard of care in the management of locally advanced adenocarcinoma of the oesophagus and junction (AEG). In randomised controlled trials (RCTs), the MAGIC regimen of ...

    Authors: JV Reynolds, SR Preston, B O’Neill, L Baeksgaard, SM Griffin, C Mariette, S Cuffe, M Cunningham, T Crosby, I Parker, K Hofland, G Hanna, LB Svendsen, CL Donohoe, C Muldoon, D O’Toole…
    Citation: BMC Cancer 2017 17:401
    Content type: Study protocol Published on:

  8. Head and neck cancer patients undergoing concomitant chemoradiotherapy (CCRT) frequently experience loss of muscle mass and reduced functional performance. Positive effects of exercise training are reported fo...

    Authors: Camilla K. Lonkvist, Simon Lønbro, Anders Vinther, Bo Zerahn, Eva Rosenbom, Hanne Primdahl, Pernille Hojman and Julie Gehl
    Citation: BMC Cancer 2017 17:400
    Content type: Study protocol Published on:

  9. Venetoclax (ABT-199), a first-in-class orally bioavailable BCL-2-selective inhibitor, was recently approved by the FDA for use in patients with 17p-deleted chronic lymphocytic leukemia who have received prior ...

    Authors: Stephen K. Tahir, Morey L. Smith, Paul Hessler, Lisa Roberts Rapp, Kenneth B. Idler, Chang H. Park, Joel D. Leverson and Lloyd T. Lam
    Citation: BMC Cancer 2017 17:399
    Content type: Research article Published on:

  10. Aboriginal and Torres Strait Islander peoples in Australia have been found to have poorer cancer survival than non-Aboriginal people. However, use of conventional relative survival analyses is limited due to a...

    Authors: Hanna E. Tervonen, Richard Walton, Hui You, Deborah Baker, David Roder, David Currow and Sanchia Aranda
    Citation: BMC Cancer 2017 17:398
    Content type: Research article Published on:

  11. The prevalence of brain metastases (BM) from uterine cancer has recently increased because of the improvement of overall survival (OS) of patients with uterine cancer due to its early detection and improved lo...

    Authors: Nakamasa Hayashi, Hideaki Takahashi, Yuzo Hasegawa, Fumi Higuchi, Masamichi Takahashi, Keishi Makino, Masatoshi Takagaki, Jiro Akimoto, Takeshi Okuda, Yoshiko Okita, Koichi Mitsuya, Yasuyuki Hirashima, Yoshitaka Narita and Yoko Nakasu
    Citation: BMC Cancer 2017 17:397
    Content type: Research article Published on:

  12. Malignant mesothelioma (MM) is an aggressive cancer of the pleural and peritoneal cavities caused by exposure to asbestos. Asbestos-induced mesotheliomas in wild-type mice have been used extensively as a precl...

    Authors: Sophie Sneddon, Ann-Marie Patch, Ian M. Dick, Stephen Kazakoff, John V. Pearson, Nicola Waddell, Richard J. N. Allcock, Robert A. Holt, Bruce W. S. Robinson and Jenette Creaney
    Citation: BMC Cancer 2017 17:396
    Content type: Research article Published on:

  13. CUL4A has been known for its oncogenic properties in various human cancers. However, its role in intrahepatic cholangiocarcinoma (iCCA) has not been explored.

    Authors: Gong -Kai Huang, Ting-Ting Liu, Shao-Wen Weng, Huey-Ling You, Yu-Ching Wei, Chang-Han Chen, Hock-Liew Eng and Wan-Ting Huang
    Citation: BMC Cancer 2017 17:395
    Content type: Research article Published on:

  15. With several new therapies becoming available, treatment of metastatic breast cancer (mBC) is evolving. The objective of this study is to describe patient characteristics, treatment patterns and real-world cli...

    Authors: Giovanni Zanotti, Matthias Hunger, Julia J Perkins, Ruslan Horblyuk and Monique Martin
    Citation: BMC Cancer 2017 17:393
    Content type: Research article Published on:

  16. Tyrosine kinase inhibitors are the first line standard of care for treatment of metastatic renal cell carcinoma (RCC). Accurate response assessment in the setting of antiangiogenic therapies remains suboptimal...

    Authors: Christian Kelly-Morland, Sarah Rudman, Paul Nathan, Susan Mallett, Giovanni Montana, Gary Cook and Vicky Goh
    Citation: BMC Cancer 2017 17:392
    Content type: Study protocol Published on:

  17. To explore the prognostic significance of preoperative prognostic nutritional index (PNI) in bladder cancer after radical cystectomy and compare the prognostic ability of inflammation-based indices.

    Authors: Ding Peng, Yan-qing Gong, Han Hao, Zhi-song He, Xue-song Li, Cui-jian Zhang and Li-qun Zhou
    Citation: BMC Cancer 2017 17:391
    Content type: Research article Published on:

  18. Single-cell mRNA profiling of circulating tumour cells may contribute to a better understanding of the biology of these cells and their role in the metastatic process. In addition, such analyses may reveal new...

    Authors: Morten Lapin, Kjersti Tjensvoll, Satu Oltedal, Milind Javle, Rune Smaaland, Bjørnar Gilje and Oddmund Nordgård
    Citation: BMC Cancer 2017 17:390
    Content type: Research article Published on:

  19. In this study, we aimed to develop an objective staging system to determine the degree of nodal metastasis in breast cancer patients undergoing neoadjuvant systemic treatment (NST).

    Authors: Tae-Kyung Yoo, Jung Min Chang, Hee-Chul Shin, Wonshik Han, Dong-Young Noh and Hyeong-Gon Moon
    Citation: BMC Cancer 2017 17:389
    Content type: Research article Published on:

  20. Mannose-binding lectin (MBL) acts in the innate immune response to Helicobacter pylori. Interleukin 8 (IL-8) is a potent cytokine produced by gastric epithelial cells in response to H. pylori. We aimed to investi...

    Authors: Young Woon Chang, Chi Hyuk Oh, Jung-Wook Kim, Jae Won Lee, Mi Ju Park, Jae-Jun Shim, Chang Kyun Lee, Jae-Young Jang, Seok Ho Dong, Hyo Jong Kim, Sung Soo Kim and Byung-Ho Kim
    Citation: BMC Cancer 2017 17:388
    Content type: Research article Published on:

  21. Authors: Charlotte M.C. Oude Ophuis, Lisa B. Koppert, Cécile de Monyé, Carolien H.M. van Deurzen, Senada Koljenović, Alexander C.J. van Akkooi, Cornelis Verhoef and Dirk J. Grünhagen
    Citation: BMC Cancer 2017 17:387
    Content type: Erratum Published on:

    The original article was published in BMC Cancer 2017 17:258

  22. Malignant mesothelioma (MM) is a deadly cancer mainly caused by previous exposure to asbestos. With a latency period up to 50 years the incidence of MM is still increasing, even in countries that banned asbest...

    Authors: Georg Johnen, Katarzyna Gawrych, Irina Raiko, Swaantje Casjens, Beate Pesch, Daniel G. Weber, Dirk Taeger, Martin Lehnert, Jens Kollmeier, Torsten Bauer, Arthur W. Musk, Bruce W. S. Robinson, Thomas Brüning and Jenette Creaney
    Citation: BMC Cancer 2017 17:386
    Content type: Research article Published on:

  23. International standards prioritize introducing routine emotional distress screening in cancer care to accurately identify patients who most need psycho-oncological treatment, and ensure that patients can acces...

    Authors: Diana Zwahlen, Theresa Tondorf, Sacha Rothschild, Michael T. Koller, Christoph Rochlitz and Alexander Kiss
    Citation: BMC Cancer 2017 17:385
    Content type: Study protocol Published on:

  24. Gastric adenocarcinoma is the third most common cause of cancer-associated death worldwide. Helicobacter pylori infection activates a signaling cascade that induces production of cytokines and chemokines involved...

    Authors: Norma Sánchez-Zauco, Javier Torres, Alejandro Gómez, Margarita Camorlinga-Ponce, Leopoldo Muñoz-Pérez, Roberto Herrera-Goepfert, Rafael Medrano-Guzmán, Silvia Giono-Cerezo and Carmen Maldonado-Bernal
    Citation: BMC Cancer 2017 17:384
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2017 17:669

  25. Ewing sarcoma is an aggressive, highly metastatic primary bone and soft tissue tumor most frequently occurring in the bone of young adolescents. Patients, especially those diagnosed with a metastatic disease, ...

    Authors: Laurens G. L. Sand, Tessa Buckle, Fijs W. B. van Leeuwen, Willem E. Corver, Alwine B. Kruisselbrink, Aart G. Jochemsen, Pancras C. W. Hogendoorn and Károly Szuhai
    Citation: BMC Cancer 2017 17:383
    Content type: Research article Published on:

  26. Glyoxalase 1 is a key enzyme in the detoxification of reactive metabolites such as methylglyoxal and induced Glyoxalase 1 expression has been demonstrated for several human malignancies. However, the regulatio...

    Authors: Nele Kreycy, Christiane Gotzian, Thomas Fleming, Christa Flechtenmacher, Niels Grabe, Peter Plinkert, Jochen Hess and Karim Zaoui
    Citation: BMC Cancer 2017 17:382
    Content type: Research article Published on:

  27. Patients with tongue cancer frequently show loss of heterozygosity (LOH) of the von Hippel–Lindau (VHL) tumor suppressor gene. However, expression of VHL protein (pVHL) in tongue cancer has rarely been investigat...

    Authors: Hisashi Hasegawa, Yoshiaki Kusumi, Takeshi Asakawa, Miyoko Maeda, Toshinori Oinuma, Tohru Furusaka, Takeshi Oshima and Mariko Esumi
    Citation: BMC Cancer 2017 17:381
    Content type: Technical advance Published on:

  28. Increasing evidence indicates that abnormal expression of GABPA is associated with tumor development and progression. However, the function and clinicopathological significance of GABPA in hepatocellular carci...

    Authors: Sheng Zhang, Kang Zhang, Piyou Ji, Xuqing Zheng, Jianbin Jin, Min Feng and Pingguo Liu
    Citation: BMC Cancer 2017 17:380
    Content type: Research article Published on:

  29. The role of axillary lymph node dissection (ALND) has increasingly been called into question among patients with positive sentinel lymph nodes. Two recent trials have failed to show a survival difference in se...

    Authors: Jana de Boniface, Jan Frisell, Yvette Andersson, Leif Bergkvist, Johan Ahlgren, Lisa Rydén, Roger Olofsson Bagge, Malin Sund, Hemming Johansson and Dan Lundstedt
    Citation: BMC Cancer 2017 17:379
    Content type: Study protocol Published on:

  30. Penetration of the mammary gland basement membrane by cancer cells is a crucial first step in tumor invasion. Using a mouse model of ductal carcinoma in situ, we previously found that inhibition of peptidylarg...

    Authors: Sachi Horibata, Katherine E. Rogers, David Sadegh, Lynne J. Anguish, John L. McElwee, Pragya Shah, Paul R. Thompson and Scott A. Coonrod
    Citation: BMC Cancer 2017 17:378
    Content type: Research article Published on:

  31. The role of irinotecan for elderly patients with LD-SCLC has been unclear, and the timing of TRT combined with chemotherapy has not been fully evaluated.

    Authors: Yuki Misumi, Hiroaki Okamoto, Jiichiro Sasaki, Noriyuki Masuda, Mari Ishii, Tsuneo Shimokawa, Yukio Hosomi, Yusuke Okuma, Makoto Nagamata, Takashi Ogura, Terufumi Kato, Masafumi Sata, Sakiko Otani, Akira Takakura, Koichi Minato, Yosuke Miura…
    Citation: BMC Cancer 2017 17:377
    Content type: Research article Published on:

  32. In view of the fact that JS-K might regulate ubiquitin E3 ligase and that ubiquitin E3 ligase plays an important role in the mechanism of CRPC formation, the goal was to investigate the probable mechanism by w...

    Authors: Guobin Tan, Mingning Qiu, Lieqian Chen, Sai Zhang, Longzhi Ke and Jianjun Liu
    Citation: BMC Cancer 2017 17:376
    Content type: Research article Published on:

  33. Prognostic factors aid in the stratification and treatment of cancer. This study evaluated prognostic importance of tumor infiltrating immune cell in patients with oral squamous cell carcinoma.

    Authors: Juan Fang, Xiaoxu Li, Da Ma, Xiangqi Liu, Yichen Chen, Yun Wang, Vivian Wai Yan Lui, Juan Xia, Bin Cheng and Zhi Wang
    Citation: BMC Cancer 2017 17:375
    Content type: Research article Published on:

  34. Despite the introduction of novel effective treatment regimens like gemcitabine plus nab-paclitaxel and FOLFIRINOX, pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive epithelial tumors....

    Authors: Sibylle Baechmann, Steffen Ormanns, Michael Haas, Stephan Kruger, Anna Remold, Dominik Paul Modest, Thomas Kirchner, Andreas Jung, Jens Werner, Volker Heinemann and Stefan Boeck
    Citation: BMC Cancer 2017 17:374
    Content type: Case report Published on:

  35. Nearly 30% of clear cell renal cell carcinoma (ccRCC) patients present with metastasis at the time of diagnosis, and the prognosis for these patients is poor. Therefore, novel potential prognostic biomarkers a...

    Authors: Yi Xu, Yanyue Tong, Jianyong Zhu, Zhangming Lei, Lijun Wan, Xiuwen Zhu, Feng Ye and Liping Xie
    Citation: BMC Cancer 2017 17:373
    Content type: Research article Published on:

  36. Renal cell carcinoma (RCC) is a tumor with immunogenic properties. Soluble interleukin-2 receptor (sIL-2R) has a role in T cell activation and may be important for immune regulation in various conditions, incl...

    Authors: Akinori Nukui, Akinori Masuda, Hideyuki Abe, Kyoko Arai, Ken-Ichiro Yoshida and Takao Kamai
    Citation: BMC Cancer 2017 17:372
    Content type: Research article Published on:

  37. Hurthle cell carcinoma makes up 3 to 5% of all thyroid cancers and is considered to be a true rarity. The aim of our study was to analyze clinical characteristics and survival rates of patients with Hurthle ce...

    Authors: Branisav Oluic, Ivan Paunovic, Zlatibor Loncar, Vladimir Djukic, Aleksandar Diklic, Milan Jovanovic, Zeljko Garabinovic, Nikola Slijepcevic, Branislav Rovcanin, Dusan Micic, Aleksandar Filipovic and Vladan Zivaljevic
    Citation: BMC Cancer 2017 17:371
    Content type: Research article Published on:

  39. The 3rd isoform of the metallothionein (MT3) gene family has been shown to be overexpressed in most ductal breast cancers. A previous study has shown that the stable transfection of MCF-7 cells with the MT3 ge...

    Authors: Brent Voels, Liping Wang, Donald A. Sens, Scott H. Garrett, Ke Zhang and Seema Somji
    Citation: BMC Cancer 2017 17:369
    Content type: Research article Published on:

  40. Gastric hepatoid adenocarcinoma (GHAC) is an atypical form of gastric cancer (GC) that has similar tissue morphology to hepatocellular carcinoma and frequently produces alpha-fetoprotein. We present an exceedi...

    Authors: Junichi Yoshizawa, Satoshi Ishizone, Meguru Ikeyama and Jun Nakayama
    Citation: BMC Cancer 2017 17:368
    Content type: Case report Published on:

  41. Prostate cancer (PCa) is characterized by clinical and biological heterogeneity and has differential outcomes and mortality rates. Therefore, it is necessary to identify molecular alterations to define new the...

    Authors: Caterina Mancarella, Irene Casanova-Salas, Ana Calatrava, Maria García-Flores, Cecilia Garofalo, Andrea Grilli, José Rubio-Briones, Katia Scotlandi and José Antonio López-Guerrero
    Citation: BMC Cancer 2017 17:367
    Content type: Research article Published on:

  42. The existence of cancer stem cells (CSCs) within a tumor bulk has been demonstrated for many solid tumors including epithelial ovarian carcinoma (EOC). CSCs have been associated to tumor invasion, metastasis a...

    Authors: Laura Zanotti, Chiara Romani, Laura Tassone, Paola Todeschini, Renata Alessandra Tassi, Elisabetta Bandiera, Giovanna Damia, Francesca Ricci, Laura Ardighieri, Stefano Calza, Sergio Marchini, Luca Beltrame, Germana Tognon, Maurizio D’Incalci, Sergio Pecorelli, Enrico Sartori…
    Citation: BMC Cancer 2017 17:366
    Content type: Research article Published on:

  43. Patients with upper gastrointestinal malignancy often require admission to hospital with dysphagia or jaundice requiring therapeutic endoscopy. Endoscopic intervention is often effective permitting rapid disch...

    Authors: R Singer, P Campbell, C Fernandes, P Statham, D Hochhauser and J Bridgewater
    Citation: BMC Cancer 2017 17:365
    Content type: Research article Published on:

  44. The obesity and lipid metabolism were previously proposed to be related with the clinical outcomes of metastatic renal cell carcinoma (mRCC). We tried to investigate the relationship between preoperative chole...

    Authors: Hakmin Lee, Yong June Kim, Eu Chang Hwang, Seok Ho Kang, Sung-Hoo Hong, Jinsoo Chung, Tae Gyun Kwon, Cheol Kwak, Hyeon Hoe Kim, Jong Jin Oh, Sang Chul Lee, Sung Kyu Hong, Sang Eun Lee and Seok-Soo Byun
    Citation: BMC Cancer 2017 17:364
    Content type: Research article Published on:

  45. A large number of chromosomal translocations of the human KMT2A gene, better known as the MLL gene, have so far been characterized. Genetic rearrangements involving KMT2A gene are frequently involved in lymphoid,...

    Authors: Estelle Menu, Nathalie Beaufils, Fabrice Usseglio, Estelle Balducci, Marina Lafage Pochitaloff, Regis Costello and Jean Gabert
    Citation: BMC Cancer 2017 17:363
    Content type: Case report Published on:

  46. Breast cancer is the leading cause of cancer morbidity among Shanghai and Hong Kong women, which contributes to 20–25% of new female cancer incidents. This study aimed to describe the temporal trend of breast ...

    Authors: Feng Wang, Lap Ah Tse, Wing-cheong Chan, Carol Chi-hei Kwok, Siu-lan Leung, Cherry Wu, Oscar Wai-kong Mang, Roger Kai-cheong Ngan, Mengjie Li, Wai-cho Yu, Koon-ho Tsang, Sze-hong Law, Xiaoping Miao, Chunxiao Wu, Ying Zheng, Fan Wu…
    Citation: BMC Cancer 2017 17:362
    Content type: Research article Published on:

  47. Endonuclease domain containing 1 (ENDOD1) is implicated in tumorigenesis and aggressiveness of multiple tumors. In this study, we aimed to investigate the role of ENDOD1 in prostate cancer (PCa).

    Authors: Jianguang Qiu, Shubin Peng, Jie Si-Tu, Cheng Hu, Wentao Huang, Yunhua Mao, Wenhan Qiu, Ke Li and Dejuan Wang
    Citation: BMC Cancer 2017 17:360
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2017 17:569

  48. The detection of somatic mutations in primary tumors is critical for the understanding of cancer evolution and targeting therapy. Multiple technologies have been developed to enable the detection of such mutat...

    Authors: Agus Darwanto, Anne-Mette Hein, Sascha Strauss, Yi Kong, Andrew Sheridan, Dan Richards, Eric Lader, Monika Ngowe, Timothy Pelletier, Danielle Adams, Austin Ricker, Nishit Patel, Andreas Kühne, Simon Hughes, Dan Shiffman, Dirk Zimmermann…
    Citation: BMC Cancer 2017 17:358
    Content type: Research article Published on:

  49. Axitinib is used after failure of first line treatment for metastatic renal cell carcinoma (mRCC). A known side effect is the increase of haemoglobin level (HbL) during treatment with a suspected correlation w...

    Authors: Alison C. Johnson, Margarida Matias, Helen Boyle, Bernard Escudier, Alicia Molinier, Brigitte Laguerre, Carole Helissey, Pierre-Emmanuel Brachet, Audrey Emmanuelle Dugué, Loic Mourey, Elodie Coquan and Florence Joly
    Citation: BMC Cancer 2017 17:355
    Content type: Research article Published on:

  50. Authors: Makito Miyake, Yosuke Morizawa, Shunta Hori, Nagaaki Marugami, Keiji Shimada, Daisuke Gotoh, Yoshihiro Tatsumi, Yasushi Nakai, Takeshi Inoue, Satoshi Anai, Kazumasa Torimoto, Katsuya Aoki, Nobumichi Tanaka and Kiyohide Fujimoto
    Citation: BMC Cancer 2017 17:353
    Content type: Erratum Published on:

    The original article was published in BMC Cancer 2017 17:237

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