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  1. This study aimed to quantify the dosimetric differences between the planned and delivered dose to tumor and normal organs in locally advanced non-small cell lung cancer (LANSCLC) treated with hypofractionated ...

    Authors: Bin Wang, Da Quan Wang, Mao Sheng Lin, Shi Pei Lu, Jun Zhang, Li Chen, Qi Wen Li, Zhang Kai Cheng, Fang Jie Liu, Jin Yu Guo, Hui Liu and Bo Qiu
    Citation: BMC Cancer 2020 20:1112
    Content type: Research article Published on:

  2. People are at a high risk of gastric cancer if their first-degree relatives suffered from atrophic gastritis (AG), intestinal metaplasia (IM), intraepithelial neoplasia (IEN), dysplasia (DYS), or gastric cance...

    Authors: Rui Wu, Cheng Yang, Lin Ji, Zhi-Ning Fan, Yu-Wen Tao and Qiang Zhan
    Citation: BMC Cancer 2020 20:1110
    Content type: Research article Published on:

  4. Pancreatic and periampullary carcinoma are aggressive tumours where preoperative assessment is challenging. Disseminated tumour cells (DTC) in the bone marrow (BM) are associated with impaired prognosis in a v...

    Authors: Harald Hugenschmidt, Knut Jørgen Labori, Cathrine Brunborg, Caroline Sophie Verbeke, Lars Thomas Seeberg, Cecilie Bendigtsen Schirmer, Anne Renolen, Elin Borgen, Bjørn Naume and Gro Wiedswang
    Citation: BMC Cancer 2020 20:1107
    Content type: Research article Published on:

  5. Biliary tract cancer (BTC) has a poor prognosis and lacks a standardized second-line therapy. Vascular endothelial growth factor (VEGF), fibroblast growth factor receptor (FGFR) 4, and platelet-derived growth ...

    Authors: Makoto Ueno, Masafumi Ikeda, Takashi Sasaki, Fumio Nagashima, Nobumasa Mizuno, Satoshi Shimizu, Hiroki Ikezawa, Nozomi Hayata, Ryo Nakajima and Chigusa Morizane
    Citation: BMC Cancer 2020 20:1105
    Content type: Research article Published on:

  6. The worldwide prevalence and incidence of neuroendocrine neoplasms (NEN) have been increasing recently, although few studies have analyzed data on the current situation of NENs in Japan. Here, the Japan Neuroe...

    Authors: Toshihiko Masui, Tetsuhide Ito, Izumi Komoto and Shinji Uemoto
    Citation: BMC Cancer 2020 20:1104
    Content type: Research article Published on:

  7. Objectives were to build a machine learning algorithm to identify bloodstream infection (BSI) among pediatric patients with cancer and hematopoietic stem cell transplantation (HSCT) recipients, and to compare ...

    Authors: Lillian Sung, Conor Corbin, Ethan Steinberg, Emily Vettese, Aaron Campigotto, Loreto Lecce, George A. Tomlinson and Nigam Shah
    Citation: BMC Cancer 2020 20:1103
    Content type: Research article Published on:

  8. Tumour subtype has a significant effect on bone metastasis in breast cancer, but population-based estimates of the prognosis of patients with bone metastases at breast cancer diagnosis are lacking. The aim of ...

    Authors: Xiao Li, Xiaoli Zhang, Jie Liu and Yinzhong Shen
    Citation: BMC Cancer 2020 20:1102
    Content type: Research article Published on:

  10. AminoIndex™ Cancer Screening (AICS (lung)) was developed as a screening test for lung cancer using a multivariate analysis of plasma-free amino acid (PFAA) profiles. According to the developed index composed o...

    Authors: Masahiko Higashiyama, Ryohei Miyazaki, Hiroshi Yamamoto, Takashi Anayama, Shinya Kikuchi, Kentaro Hirohashi, Jiro Okami, Tomohiro Maniwa, Toru Kimura, Kazumasa Orihashi and Fumio Imamura
    Citation: BMC Cancer 2020 20:1100
    Content type: Research article Published on:

  11. Identifying the mutation status of KRAS is important for optimizing treatment in patients with colorectal cancer (CRC). The aim of this study was to investigate the predictive value of haematological parameter...

    Authors: Yinghao Cao, Junnan Gu, Lizhao Yan, Shenghe Deng, Fuwei Mao, Wentai Cai, Hang Li, Xinghua Liu, Jiliang Wang, Ke Wu and Kailin Cai
    Citation: BMC Cancer 2020 20:1099
    Content type: Research article Published on:

  12. Follow-up after curative surgery is increasingly recognized as an important component of breast cancer care. Although current guideline regulates the follow-ups, there are no relevant studies on the adherence ...

    Authors: Ran Feng, Jingfeng Jing, Xiaojun Zhang, Ming Li and Jinnan Gao
    Citation: BMC Cancer 2020 20:1098
    Content type: Research article Published on:

  13. Cancer is widely recognized as a global public health problem. Breast, prostate, and cervical cancer are among the most frequent types in developing countries. Assessing their incidence and mortality by region...

    Authors: Juliana Alexandra Hernández Vargas, Paula Ximena Ramírez Barbosa, Ana Milena Gil Quijano, Ana María Valbuena, Lizbeth Acuña and Jaime Alberto González
    Citation: BMC Cancer 2020 20:1097
    Content type: Research article Published on:

    The Correspondence to this article has been published in BMC Cancer 2024 24:232

  14. The incidence of thyroid cancer (TC) has increased rapidly over the past few decades in Korea. This study investigated whether the TC epidemic has been driven by overdiagnosis.

    Authors: Hee-Yeon Kang, Ikhan Kim, Yeon-Yong Kim, Jinwook Bahk and Young-Ho Khang
    Citation: BMC Cancer 2020 20:1096
    Content type: Research article Published on:

  15. Hypopharyngeal squamous cell carcinoma (HSCC) is a rare type of head and neck cancer with poor prognosis. However, till now, there is still no model predicting the survival outcomes for HSCC patients. We aim t...

    Authors: Xin Tang, Tong Pang, Wei-feng Yan, Wen-lei Qian, You-ling Gong and Zhi-gang Yang
    Citation: BMC Cancer 2020 20:1095
    Content type: Research article Published on:

  16. The efficacy of immune checkpoint blockade in the treatment of microsatellite instability (MSI)-high tumors was recently reported. Therefore, the acquisition of histological specimens is desired in cases of un...

    Authors: Mitsuru Sugimoto, Hiroki Irie, Tadayuki Takagi, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Yuki Sato, Jun Nakamura, Mika Takasumi, Minami Hashimoto, Tsunetaka Kato, Ryoichiro Kobashi, Yasuyuki Kobayashi, Yuko Hashimoto, Takuto Hikichi and Hiromasa Ohira
    Citation: BMC Cancer 2020 20:1094
    Content type: Research article Published on:

  18. This study aimed to evaluate the prognostic impact of nutritional and inflammatory measures (controlling nutritional status (CONUT) score, prognostic nutritional index (PNI), and modified Glasgow prognostic sc...

    Authors: Yasuyuki Takamizawa, Dai Shida, Narikazu Boku, Yuya Nakamura, Yuka Ahiko, Takefumi Yoshida, Taro Tanabe, Atsuo Takashima and Yukihide Kanemitsu
    Citation: BMC Cancer 2020 20:1092
    Content type: Research article Published on:

  19. Eligibility criteria are a critical part of clinical trials, as they define the patient population under investigation. Besides certain patient characteristics, clinical trials often include biomarker testing ...

    Authors: Hanna Huebner, Christian M. Kurbacher, Geoffrey Kuesters, Andreas D. Hartkopf, Michael P. Lux, Jens Huober, Bernhard Volz, Florin-Andrei Taran, Friedrich Overkamp, Hans Tesch, Lothar Häberle, Diana Lüftner, Markus Wallwiener, Volkmar Müller, Matthias W. Beckmann, Erik Belleville…
    Citation: BMC Cancer 2020 20:1091
    Content type: Research article Published on:

  20. All-trans retinoic acid (ATRA)-based treatment of acute promyelocytic leukemia (APL) is the most successful pharmacological treatment of acute myeloid leukemia (AML). Recent development of inhibitors of mutated i...

    Authors: Vilma Dembitz, Hrvoje Lalic, Ivan Kodvanj, Barbara Tomic, Josip Batinic, Klara Dubravcic, Drago Batinic, Antonio Bedalov and Dora Visnjic
    Citation: BMC Cancer 2020 20:1090
    Content type: Research article Published on:

  21. This study is designed to investigate the clinical value of systemic chemotherapy combined with bronchoscopic interventional cryotherapy in the treatment of lung cancer.

    Authors: Feng Xu, Jian Song, Beizheng Xu, Jiang Wang, Jianjun Mao, Haiyan Liu, Xuanmei Li and Aibing Deng
    Citation: BMC Cancer 2020 20:1089
    Content type: Research article Published on:

  22. Autologous stem cell transplantation (ASCT) is a well-established approach to treatment of patients with relapsed/refractory (R/R) Hodgkin lymphoma (HL) recommended by both the European Society for Medical Onc...

    Authors: Anna Sureda, Marc André, Peter Borchmann, Maria G. da Silva, Christian Gisselbrecht, Theodoros P. Vassilakopoulos, Pier Luigi Zinzani and Jan Walewski
    Citation: BMC Cancer 2020 20:1088
    Content type: Review Published on:

  23. For patients with multiple myeloma (MM), each additional line of therapy (LOT) is associated with lower response rates, shorter treatment duration and treatment-free intervals, and increased rates of toxicitie...

    Authors: Rafael Fonseca, Saad Z. Usmani, Maneesha Mehra, Mary Slavcev, Jianming He, Sarah Cote, Annette Lam, Jon Ukropec, Eric M. Maiese, Sandhya Nair, Ravi Potluri and Peter M. Voorhees
    Citation: BMC Cancer 2020 20:1087
    Content type: Research article Published on:

  24. Colorectal cancer (CRC) is the third most diagnosed malignancy worldwide. The global burden is expected to increase along with ongoing westernized behaviors and lifestyle. The etiology of CRC remains elusive a...

    Authors: Mouadh Barbirou, Henok G. Woldu, Ikram Sghaier, Sinda A. Bedoui, Amina Mokrani, Radhia Aami, Amel Mezlini, Besma Yacoubi-Loueslati, Peter J. Tonellato and Balkiss Bouhaouala-Zahar
    Citation: BMC Cancer 2020 20:1086
    Content type: Research article Published on:

  25. Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is normally detectable in embryonic tissues and absent in adult tissues. ROR1 was shown to inhibit apoptosis, potentiate EGFR signaling and reported to be...

    Authors: Giovanna Schiavone, Samantha Epistolio, Vittoria Martin, Francesca Molinari, Jessica Barizzi, Luca Mazzucchelli, Milo Frattini and Luciano Wannesson
    Citation: BMC Cancer 2020 20:1085
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2020 20:1196

  26. Tools based on diagnostic prediction models are available to help general practitioners (GP) diagnose colorectal cancer. It is unclear how well they perform and whether they lead to increased or quicker diagno...

    Authors: Bogdan Grigore, Ruth Lewis, Jaime Peters, Sophie Robinson and Christopher J. Hyde
    Citation: BMC Cancer 2020 20:1084
    Content type: Research article Published on:

  27. Although great progress has been made in treatment regimens, cervical cancer remains as one of the most common cancer in women worldwide. Studies focusing on molecules that regulate carcinogenesis may provide ...

    Authors: Nehla Banu, Annie Riera-Leal, Jesse Haramati, Pablo Cesar Ortiz-Lazareno, Sandeep Surendra Panikar, Blanca Estela Bastidas-Ramirez, Gloria Yareli Gutierrez-Silerio, Fabiola Solorzano-Ibarra, Martha Cecilia Tellez-Bañuelos, Jorge Gutierrez-Franco, Miriam Ruth Bueno-Topete, Ana Laura Pereira-Suarez and Susana del Toro-Arreola
    Citation: BMC Cancer 2020 20:1083
    Content type: Research article Published on:

  28. The ability to detect tumor-specific biomarkers in real-time using optical imaging plays a critical role in preclinical studies aimed at evaluating drug safety and treatment response. In this study, we enginee...

    Authors: Harini Kantamneni, Shravani Barkund, Michael Donzanti, Daniel Martin, Xinyu Zhao, Shuqing He, Richard E. Riman, Mei Chee Tan, Mark C. Pierce, Charles M. Roth, Vidya Ganapathy and Prabhas V. Moghe
    Citation: BMC Cancer 2020 20:1082
    Content type: Research article Published on:

  29. A secondary malignancy is the most serious complication in lung cancer (LC) survivors. This study aimed to evaluate the clinicopathological features, predictable risk factors and survival of patients with LC w...

    Authors: Huabin Wang, Yin Yin, Ru Wang, Junbin Huang, Hongman Xue, Yucai Cheng, Lidan Zhang and Chun Chen
    Citation: BMC Cancer 2020 20:1081
    Content type: Research article Published on:

  30. Little is known about the presentation, help seeking behaviour for breast cancer in Singapore. Nor was there a study exploring the experience of patients in their breast cancer journey.

    Authors: Celene W. Q. Ng, Jennifer N. W. Lim, Jenny Liu and Mikael Hartman
    Citation: BMC Cancer 2020 20:1080
    Content type: Research article Published on:

  31. In recent years, the identification of genetic and phenotypic biomarkers of cancer for prevention, early diagnosis and patient stratification has been a main objective of research in the field. Different multi...

    Authors: J. C. Triviño, A. Ceba, E. Rubio-Solsona, D. Serra, I. Sanchez-Guiu, G. Ribas, R. Rosa, M. Cabo, L. Bernad, G. Pita, A. Gonzalez-Neira, G. Legarda, J. L. Diaz, A. García-Vigara, A. Martínez-Aspas, M. Escrig…
    Citation: BMC Cancer 2020 20:1079
    Content type: Research article Published on:

  32. In low-income countries breast cancer awareness (BCA) is essential to reduce the proportion of advanced stage presentations of breast cancer. There is a lack of studies using multivariable techniques to explor...

    Authors: Rukaiya Malik, Numa Vera, Chandra Dayal, Abhay Choudhari, Jyotishna Mudaliar, Amanda Noovao Hill, Ilisapeci Kubuabola and Ronny Gunnarsson
    Citation: BMC Cancer 2020 20:1078
    Content type: Research article Published on:

  33. The purpose of this study was to assess trends in incidence and presentation of colorectal cancer (CRC) over a period of 37 years in a stable population in Mid-Norway. Secondarily, we wanted to predict the fut...

    Authors: Øystein Høydahl, Tom-Harald Edna, Athanasios Xanthoulis, Stian Lydersen and Birger Henning Endreseth
    Citation: BMC Cancer 2020 20:1077
    Content type: Research article Published on:

  34. Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype with basal features, lacking the expression of receptors targeted successfully in other breast cancer subtypes. Treatment response to...

    Authors: Alexander Ring, Pushpinder Kaur and Julie E. Lang
    Citation: BMC Cancer 2020 20:1076
    Content type: Research article Published on:

  35. Resistance to chemotherapy is the most common cause of treatment failure in acute myeloid leukemia (AML) and the drug efflux pump ABCB1 is a critical mediator. Recent studies have identified promoter transloca...

    Authors: Mark S. Williams, Naseer J. Basma, Fabio M. R. Amaral, Gillian Williams, John P. Weightman, Wolfgang Breitwieser, Louisa Nelson, Stephen S. Taylor, Daniel H. Wiseman and Tim C. P. Somervaille
    Citation: BMC Cancer 2020 20:1075
    Content type: Research article Published on:

  36. Breast cancer (BC) is a major public health issue. More than one out of five women treated for breast cancer will develop lymphedema in an upper extremity. Current evidence advocates transdisciplinary oncologi...

    Authors: María Nieves Muñoz-Alcaraz, Luis Ángel Pérula-de-Torres, Jesús Serrano-Merino, Antonio José Jiménez-Vílchez, María Victoria Olmo-Carmona, María Teresa Muñoz-García, Cruz Bartolomé-Moreno, Bárbara Oliván-Blázquez and Rosa Magallón-Botaya
    Citation: BMC Cancer 2020 20:1074
    Content type: Study protocol Published on:

  37. The clinicopathological classification of breast cancer is proposed according to therapeutic purposes. It is simplified and can be conducted easily in clinical practice, and this subtyping undoubtedly contribu...

    Authors: Ming Ni, Xiaoming Zhou, Jingwei Liu, Haiyang Yu, Yuanxiang Gao, Xuexi Zhang and Zhiming Li
    Citation: BMC Cancer 2020 20:1073
    Content type: Research article Published on:

  38. The nuclear transport system has been proposed to be indispensable for cell proliferation and invasion in cancers. Prognostic biomarkers and molecular targets in nuclear transport systems have been developed. ...

    Authors: Zheng Zhu, Yang Lan, Lihong Wang, Jia Ge, Jiao Wang, Feng Liu, Zhicheng He, Hua Zhang, Min Luo, Dandan Lin, Yaoyao Tan, Yuanyuan Xu and Tao Luo
    Citation: BMC Cancer 2020 20:1072
    Content type: Research article Published on:

  39. Colon cancer is the most common type of gastrointestinal cancer and has high morbidity and mortality. Colon adenocarcinoma (COAD) is the main pathological type of colon cancer, and much evidence has supported ...

    Authors: Jihang Luo, Puyu Liu, Leibo Wang, Yi Huang, Yuanyan Wang, Wenjing Geng, Duo Chen, Yuju Bai and Ze Yang
    Citation: BMC Cancer 2020 20:1071
    Content type: Research article Published on:

  40. There is uncertainty about the effectiveness of clinical breast examination (CBE) and conflicting recommendations regarding its usefulness as a screening tool for breast cancer. This paper provides an overview...

    Authors: Tran Thu Ngan, Nga T. Q. Nguyen, Hoang Van Minh, Michael Donnelly and Ciaran O’Neill
    Citation: BMC Cancer 2020 20:1070
    Content type: Research article Published on:

  41. Melanoma is the most aggressive type of skin cancer and is associated with environmental and genetic risk factors. It originates in melanocytes, the pigment-producing cells. Single nucleotide polymorphisms (SN...

    Authors: Larissa B. Reis, Renato M. Bakos, Fernanda S. L. Vianna, Gabriel S. Macedo, Vanessa C. Jacovas, André M. Ribeiro-dos-Santos, Sidney Santos, Lúcio Bakos and Patricia Ashton-Prolla
    Citation: BMC Cancer 2020 20:1069
    Content type: Research article Published on:

  42. S-1 and cyclophosphamide (CPA) can be given orally, and their combination may have great potential for treating metastatic breast cancer (MBC). A phase I study of sequential S-1 and CPA therapy was conducted i...

    Authors: Keiko Yanai, Takaaki Fujii, Jun Horiguchi, Yuko Nakazawa, Sasagu Kurozumi, Sayaka Obayashi, Reina Yajima and Ken Shirabe
    Citation: BMC Cancer 2020 20:1068
    Content type: Research article Published on:

  43. Estimating the risk of lymph node metastasis (LNM) is crucial for determining subsequent treatments following curative resection of early colorectal cancer (ECC). This multicenter study analyzed the risk facto...

    Authors: Chunyan Zeng, Dandan Xiong, Fei Cheng, Qingtian Luo, Qiang Wang, Jun Huang, Guilian Lan, Huan Zhong and Youxiang Chen
    Citation: BMC Cancer 2020 20:1067
    Content type: Research article Published on:

  44. Heterogeneity of metastatic renal cell carcinoma (RCC) constraints accurate prognosis prediction of the tumor. We therefore aimed at developing a novel nomogram for accurate prediction of overall survival (OS)...

    Authors: Wenwen Zheng, Weiwei Zhu, Shengqiang Yu, Kangqi Li, Yuexia Ding, Qingna Wu, Qiling Tang, Quan Zhao, Congxiao Lu and Chenyu Guo
    Citation: BMC Cancer 2020 20:1066
    Content type: Research article Published on:

  45. Pancreatic cancer is a malignant tumor with high mortality. Acidic nuclear phosphoprotein 32 family member E (ANP32E), a specific H2A.Z chaperone, has been shown to contribute to breast cancer development. How...

    Authors: Jianwei Zhang, Zhongmin Lan, Guotong Qiu, Hu Ren, Yajie Zhao, Zongting Gu, Zongze Li, Lin Feng, Jin He and Chengfeng Wang
    Citation: BMC Cancer 2020 20:1065
    Content type: Research article Published on:

  46. Immunomodulatory activities of human mesenchymal stromal /stem cells (hMSCs) has been widely recognized as the most critical function of hMSCs for exerting its therapeutic effects. However, the detailed mechan...

    Authors: Tao Na, Kehua Zhang and Bao-Zhu Yuan
    Citation: BMC Cancer 2020 20:1064
    Content type: Research article Published on:

  47. Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited systemic treatment options. RX-5902 is a novel anti-cancer agent that inhibits phosphorylated-p68 and thus attenuates nu...

    Authors: John J. Tentler, Julie Lang, Anna Capasso, Deog Joong Kim, Ely Benaim, Young B. Lee, Andrew Eisen, Stacey M. Bagby, Sarah J. Hartman, Betelehem W. Yacob, Brian Gittleman, Todd M. Pitts, Roberta Pelanda, S. Gail Eckhardt and Jennifer R. Diamond
    Citation: BMC Cancer 2020 20:1063
    Content type: Research article Published on:

  48. Extensive research has revealed that genes play a pivotal role in tumor development and growth. However, the underlying involvement of gene expression in gastric carcinoma (GC) remains to be investigated further.

    Authors: Zhenhua Yin, Dejun Wu, Jianping Shi, Xiyi Wei, Nuyun Jin, Xiaolan Lu and Xiaohan Ren
    Citation: BMC Cancer 2020 20:1062
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2020 20:1141

  49. Diffuse large B cell lymphoma (DLBCL) is the commonest lymphoma that is highly aggressive where one-third of the patients relapse despite effective treatment. Interaction between the lymphoma cells and the non...

    Authors: Sewa Rijal, Johanna Kok, Caitlin Coombes, Lillian Smyth, Jayde Hourigan, Sanjiv Jain and Dipti Talaulikar
    Citation: BMC Cancer 2020 20:1061
    Content type: Research article Published on:

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