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  1. Tetraspanin CD82 is a tumor metastasis suppressor that is known to down regulate in various metastatic cancers. However, the exact mechanism by which CD82 prevents cancer metastasis is unclear. This study aims...

    Authors: Pushpaja Dodla, Vanitha Bhoopalan, Sok Kean Khoo, Cindy Miranti and Suganthi Sridhar
    Citation: BMC Cancer 2020 20:1211
    Content type: Research article Published on:

  2. To investigate the clinicopathological characteristics of head and neck small cell carcinoma (H&NSmCC) and identify prognostic factors on the basis of the Surveillance, Epidemiology and End Results (SEER) data...

    Authors: Chen-xi Yu, Feiluore Yibulayin, Lei Feng, Meng Wang, Meng-meng Lu, Yuan Luo, Hui Liu, Zhi-cheng Yang and Alimujiang Wushou
    Citation: BMC Cancer 2020 20:1208
    Content type: Research article Published on:

  3. Glycolysis is a central metabolic pathway for tumor cells. However, the potential roles of glycolysis-related genes in renal cell carcinoma (RCC) have not been investigated.

    Authors: Fangshi Xu, Yibing Guan, Li Xue, Shanlong Huang, Ke Gao, Zhen Yang and Tie Chong
    Citation: BMC Cancer 2020 20:1207
    Content type: Research article Published on:

  4. We aimed to identify whether neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are more useful predictors after initial intention to treat than at the time of diagnosis.

    Authors: Ju-Yeon Kim, Eun Jung Jung, Jae-Myung Kim, Han Shin Lee, Seung-Jin Kwag, Ji-Ho Park, Taejin Park, Sang-Ho Jeong, Chi-Young Jeong and Young-Tae Ju
    Citation: BMC Cancer 2020 20:1206
    Content type: Research article Published on:

  5. Ovarian cancer (OV) is one of the most common malignant tumors of gynecology oncology. The lack of effective early diagnosis methods and treatment strategies result in a low five-year survival rate. Also, immu...

    Authors: Shibai Yan, Juntao Fang, Yongcai Chen, Yong Xie, Siyou Zhang, Xiaohui Zhu and Feng Fang
    Citation: BMC Cancer 2020 20:1205
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2021 21:55

  6. Hepatocellular carcinoma (HCC) is a malignancy with high incidence and mortality rates worldwide. Alcohol dehydrogenases (ADHs) are huge family of dehydrogenase enzymes and associated with the prognosis of var...

    Authors: Xiangye Liu, Tingting Li, Delong Kong, Hongjuan You, Fanyun Kong and Renxian Tang
    Citation: BMC Cancer 2020 20:1204
    Content type: Research article Published on:

  7. While circulating tumor cells may serve as minimally invasive cancer markers for bladder cancers, the relationship between primary bladder cancers and circulating tumor cells in terms of somatic mutations is l...

    Authors: Tae-Min Kim, Jin-seon Yoo, Hyong Woo Moon, Kyung Jae Hur, Jin Bong Choi, Sung-Hoo Hong, Ji Youl Lee and U-Syn Ha
    Citation: BMC Cancer 2020 20:1203
    Content type: Research article Published on:

  8. Response to modern treatment strategies, which combine cytotoxic compounds with immune stimulatory agents and targeted treatment is highly variable among MCL patients. Thus, providing prognostic and predictive...

    Authors: Lavanya Lokhande, Venera Kuci Emruli, Arne Kolstad, Martin Hutchings, Riikka Räty, Mats Jerkeman and Sara Ek
    Citation: BMC Cancer 2020 20:1202
    Content type: Research article Published on:

  9. The mechanisms of action and efficacy of cisplatin and paclitaxel at cell population level are well studied and documented, however the localized spatio-temporal effects of the drugs are less well understood. ...

    Authors: M. V. Sheraton, G. G. Y. Chiew, V. Melnikov, E. Y. Tan, K. Q. Luo, N. Verma and P. M. A. Sloot
    Citation: BMC Cancer 2020 20:1201
    Content type: Research article Published on:

  10. The study aimed to propose a modified N stage of esophageal cancer (EC) on the basis of the number of positive lymph node (PLN) and the number of negative lymph node (NLN) simultaneously.

    Authors: Jinling Zhang, Hongyan Li, Liangjian Zhou, Lianling Yu, Fengyuan Che and Xueyuan Heng
    Citation: BMC Cancer 2020 20:1200
    Content type: Research article Published on:

  11. To determine if extended chemotherapy improves survival outcomes in patients with platinum-sensitive relapsed epithelial ovarian cancer (EOC) who have residual disease after six cycles of second-line chemother...

    Authors: Se Ik Kim, Woo Yeon Hwang, Maria Lee, Hee Seung Kim, Kidong Kim, Hyun Hoon Chung, Jae Hong No, Jae-Weon Kim, Yong Beom Kim, Noh Hyun Park, Yong-Sang Song and Dong Hoon Suh
    Citation: BMC Cancer 2020 20:1199
    Content type: Research article Published on:

  13. The incidence of cutaneous malignant melanoma (CMM) is increasing worldwide. In Sweden, over 4600 cases were diagnosed in 2018. The prognosis after radical surgery varies considerably with tumor stage. In rece...

    Authors: Ylva Naeser, Hildur Helgadottir, Yvonne Brandberg, Johan Hansson, Roger Olofsson Bagge, Nils O. Elander, Christian Ingvar, Karolin Isaksson, Petra Flygare, Cecilia Nilsson, Frida Jakobsson, Olga del Val Munoz, Antonis Valachis, Malin Jansson, Charlotte Sparring, Lars Ohlsson…
    Citation: BMC Cancer 2020 20:1197
    Content type: Study protocol Published on:

  14. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Giovanna Schiavone, Samantha Epistolio, Vittoria Martin, Francesca Molinari, Jessica Barizzi, Luca Mazzucchelli, Milo Frattini and Luciano Wannesson
    Citation: BMC Cancer 2020 20:1196
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2020 20:1085

  15. Streptozocin (STZ) is used for treating both pancreatic (PanNET) and gastrointestinal (GI-NET) neuroendocrine tumors but its therapeutic efficacy is relatively low in GI-NETs. Therefore, it has become pivotal ...

    Authors: Hirofumi Watanabe, Yuto Yamazaki, Fumiyoshi Fujishima, Komoto Izumi, Masayuki Imamura, Susumu Hijioka, Kazuhiro Toriyama, Yasushi Yatabe, Atsushi Kudo, Fuyuhiko Motoi, Michiaki Unno and Hironobu Sasano
    Citation: BMC Cancer 2020 20:1195
    Content type: Research article Published on:

  16. Due to the increased risk of viral infection and the severe shortage of medical resources during the pandemic of COVID-19, most hospitals in the epidemic areas significantly reduced non-emergency admissions an...

    Authors: Songxiao Xu, Xiangdong Cheng, Zhiwen Pan, Qian Song, Yihong Wang, Juan Xiong, Yongyi Chen, Fan Fan, Jing Zhu, Wanying Wu, Xueying Deng, Yanpin Yu, Xiaohong Xu, Wenhu Chen, Tao Zhu, Yang Yu…
    Citation: BMC Cancer 2020 20:1194
    Content type: Research article Published on:

  17. Acute myeloid leukemia (AML) is a heterogeneous disease that frequently relapses after standard chemotherapy. Therefore, there is a need for the development of novel chemotherapeutic agents that could treat AM...

    Authors: Sook-Kyoung Heo, Eui-Kyu Noh, Ho-Min Yu, Do Kyoung Kim, Hye Jin Seo, Yoo Jin Lee, Jaekyung Cheon, Su Jin Koh, Young Joo Min, Yunsuk Choi and Jae-Cheol Jo
    Citation: BMC Cancer 2020 20:1193
    Content type: Research article Published on:

  18. Lymphovascular invasion (LVI), which includes vascular or lymphatic invasions, is a representative prognostic factor even in patients with resected stage IA non-small cell lung cancer (NSCLC). Because tegafur-...

    Authors: Tomoshi Tsuchiya, Ryotaro Kamohara, Masashi Muraoka, Takeshi Nagayasu, Sho Saeki, Mitsuhiro Takenoyama, Makoto Suzuki, Kazuo Inada, Shoji Tokunaga, Tomayoshi Hayashi, Shogo Urabe, Takaomi Koga, Shinji Akamine and Kenji Sugio
    Citation: BMC Cancer 2020 20:1192
    Content type: Research article Published on:

  19. Organized breast and cervical cancer screening programme could only provide services at no cost for a fraction of socioeconomic-deprived women in China and other low-resource countries, however, little evidenc...

    Authors: Heling Bao, Limin Wang, Matthew Brown, Mei Zhang, Katherine Hunt, Jiangli Di, Zhenping Zhao, Shu Cong, Jing Fan, Liwen Fang and Linhong Wang
    Citation: BMC Cancer 2020 20:1191
    Content type: Research article Published on:

  20. Cisplatin is the first-line chemotherapeutic drug for non-small cell lung cancer (NSCLC), and emerging evidences suggests that targeting circular RNAs (circRNAs) is an effective strategy to increase cisplatin-...

    Authors: Xiang Zhu, Jing Han, Huiyin Lan, Qingren Lin, Yuezhen Wang and Xiaojiang Sun
    Citation: BMC Cancer 2020 20:1190
    Content type: Research article Published on:

  21. Lung cancer is the leading cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. In traditional anti-cancer therapy, epidermal growth factor recep...

    Authors: Hao Gong, Yongwen Li, Yin Yuan, Weiting Li, Hongbing Zhang, Zihe Zhang, Ruifeng Shi, Minghui Liu, Chao Liu, Chen Chen, Hongyu Liu and Jun Chen
    Citation: BMC Cancer 2020 20:1189
    Content type: Research article Published on:

  22. It is often difficult to diagnose inflammatory bowel disease (IBD)-associated neoplasia endoscopically due to background inflammation. In addition, due to the absence of sensitive tumor biomarkers, countermeas...

    Authors: Hideaki Kinugasa, Sakiko Hiraoka, Kazuhiro Nouso, Shumpei Yamamoto, Mami Hirai, Hiroyuki Terasawa, Eriko Yasutomi, Shohei Oka, Masayasu Ohmori, Yasushi Yamasaki, Toshihiro Inokuchi, Masahiro Takahara, Keita Harada, Takehiro Tanaka and Hiroyuki Okada
    Citation: BMC Cancer 2020 20:1188
    Content type: Research article Published on:

  23. MNAT1 (menage a trois 1, MAT1), a cyclin-dependent kinase-activating kinase (CAK) complex, highly expressed in diverse cancers and was involved in cancer molecular pathogenesis. However, its deliverance profil...

    Authors: Chensheng Qiu, Weiliang Su, Nana Shen, Xiaoying Qi, Xiaolin Wu, Kai Wang, Lin Li, Zhu Guo, Hao Tao, Guanrong Wang, Bohua Chen and Hongfei Xiang
    Citation: BMC Cancer 2020 20:1187
    Content type: Research article Published on:

  24. Choroidal metastases are the most common eye metastatic site. The prevalence of choroidal metastases in NSCLC patients has been reported to vary from 0.2 to 7% in historical series. Although previously reporte...

    Authors: Clémentine Bouchez, Johan Pluvy, Ghassen Soussi, Marina Nguenang, Solenn Brosseau, Morgan Tourne, Mégane Collin, Nathalie Théou-Anton, Alice Guyard, Jamila Ammar, Antoine Khalil, Gérard Zalcman and Valérie Gounant
    Citation: BMC Cancer 2020 20:1186
    Content type: Research article Published on:

  25. Immune checkpoint inhibitors (ICI) either alone or in combination with chemotherapy have expanded our choice of agents for the palliative treatment of non-small cell lung cancer (NSCLC) patients. Unfortunately...

    Authors: Wolfgang M. Brueckl, Joachim H. Ficker and Gloria Zeitler
    Citation: BMC Cancer 2020 20:1185
    Content type: Review Published on:

  26. Borderline resectable pancreatic cancer (BRPC) is frequently associated with positive surgical margins and a poor prognosis because the tumor is in contact with major vessels. This study evaluated the relation...

    Authors: Sho Yasuta, Tatsushi Kobayashi, Hidetoshi Aizawa, Shinichiro Takahashi, Masafumi Ikeda, Masaru Konishi, Motohiro Kojima, Hirofumi Kuno, Katsuhiko Uesaka, Soichiro Morinaga, Atsushi Miyamoto, Hirochika Toyama, Norihisa Takakura, Keishi Sugimachi and Wataru Takayama
    Citation: BMC Cancer 2020 20:1184
    Content type: Research article Published on:

  28. Tumor micro-angiogenesis and lymphangiogenesis are effective prognostic predictors in many solid malignancies. However, its role on Xp11.2 translocation RCC has not been fully elucidated. Herein, we purposed t...

    Authors: Wenliang Ma, Jun Yang, Ning Liu, Xiaohong Pu, Feng Qu, Linfeng Xu, Xiaozhi Zhao, Xiaogong Li, Gutian Zhang, Hongqian Guo, Dongmei Li and Weidong Gan
    Citation: BMC Cancer 2020 20:1182
    Content type: Research article Published on:

  29. Thyroid malignancies are among the most common endocrine cancers worldwide. Owing to the angiogenic nature of these malignancies, tyrosine kinase inhibitors (TKIs) are an attractive potential treatment. Howeve...

    Authors: Saumil Datar, Maria Cabanillas, Ramona Dadu, David Ost and Horiana B. Grosu
    Citation: BMC Cancer 2020 20:1181
    Content type: Research article Published on:

  30. Anchoring filament protein ladinin-1 (LAD1) was related to the aggressive progression of breast, lung, laryngeal and thyroid cancers. However, the association of LAD1 with colorectal cancer remained unknown. H...

    Authors: Byul Moon, Suk-Jin Yang, Seong Min Park, Sang-Hyun Lee, Kyu Sang Song, Eun-Jeong Jeong, Mijin Park, Jang-Seong Kim, Young Il Yeom and Jung-Ae Kim
    Citation: BMC Cancer 2020 20:1180
    Content type: Research article Published on:

  31. Gastric and colorectal cancers are the most common malignant tumours, leading to a significant number of cancer-related deaths worldwide. Recently, increasing evidence has demonstrated that cancer cells exhibi...

    Authors: Azer Farah, Maria Kabbage, Salsabil Atafi, Amira Jaballah Gabteni, Mouadh Barbirou, Mouna Madhioub, Lamine Hamzaoui, Mousadak Azzouz Mohamed, Hassen Touinsi, Asma Ouakaa Kchaou, Emna Chelbi, Samir Boubaker, Rahma Ben Abderrazek and Balkiss Bouhaouala-Zahar
    Citation: BMC Cancer 2020 20:1179
    Content type: Research article Published on:

  32. Bladder cancer cells orchestrate tumour progression by pro-inflammatory cytokines. Cytokines modulate the local tumour microenvironment and increase the susceptibility of tumour distant tissues for metastasis....

    Authors: A. John, C. Günes, C. Bolenz, S. Vidal-y-Sy, A. T. Bauer, S. W. Schneider and C. Gorzelanny
    Citation: BMC Cancer 2020 20:1178
    Content type: Research article Published on:

  33. Cancer of unknown primary (CUP) is usually treated with nonselective and empirical chemotherapy; however, its prognosis is generally poor, with a median survival of less than a year. Thus, clinicians eagerly a...

    Authors: Yosuke Mitani, Masashi Kanai, Tadayuki Kou, Shigeki Kataoka, Keitaro Doi, Junichi Matsubara, Shinya Ohashi, Shigemi Matsumoto and Manabu Muto
    Citation: BMC Cancer 2020 20:1177
    Content type: Case report Published on:

  35. Early diagnosis is important for the timely treatment of gallbladder carcinoma (GBC) patients and may lead to increased survival outcomes. Here, we have applied serological proteome analysis (SERPA), an immuno...

    Authors: Javed Akhtar, Ratna Priya, Vaishali Jain, Puja Sakhuja, Anil Kumar Agarwal, Surbhi Goyal, Ravindra Varma Polisetty, Ravi Sirdeshmukh, Sudeshna Kar and Poonam Gautam
    Citation: BMC Cancer 2020 20:1175
    Content type: Research article Published on:

  36. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Matthias Kröz, Marcus Reif, Augustina Glinz, Bettina Berger, Andreas Nikolaou, Roland Zerm, Benno Brinkhaus, Matthias Girke, Arndt Büssing and Christoph Gutenbrunner
    Citation: BMC Cancer 2020 20:1174
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2017 17:166

  37. Breast cancer (BC) is the most common malignancy in Latin American women, but with a wide variability with respect to their mortality. This study aims to estimate the mortality rates from BC in Peruvian women ...

    Authors: J. Smith Torres-Roman, Jose Fabian Martinez-Herrera, Greta Carioli, Jorge Ybaseta-Medina, Bryan Valcarcel, Joseph A. Pinto, Alfredo Aguilar, Katherine A. McGlynn and Carlo La Vecchia
    Citation: BMC Cancer 2020 20:1173
    Content type: Research article Published on:

  38. Routine screening of patients with head and neck squamous cell carcinomas (HNSCCs) for synchronous malignancies using oesophagoscopy and bronchoscopy had been controversial. The aim of this study is therefore ...

    Authors: Shi Yeung Ho and Raymond King Yin Tsang
    Citation: BMC Cancer 2020 20:1172
    Content type: Research article Published on:

  39. The treatment of Ewing sarcoma, an aggressive bone and soft tissue sarcoma, is associated with suboptimal outcomes and significant side-effects. Consequently, there is an urgent need to identify novel therapie...

    Authors: Torin Waters, Kelli L. Goss, Stacia L. Koppenhafer, William W. Terry and David J. Gordon
    Citation: BMC Cancer 2020 20:1171
    Content type: Research article Published on:

  40. The most common gender-specific malignancies are cancers of the breast and the prostate. In developing countries, cancer screening of all at risk is impractical because of healthcare resource limitations. Thus...

    Authors: Mahdieh Montazeri, Benyamin Hoseini, Neda Firouraghi, Fatemeh Kiani, Hosein Raouf-Mobini, Adele Biabangard, Ali Dadashi, Vahideh Zolfaghari, Leila Ahmadian, Saeid Eslami, Robert Bergquist, Nasser Bagheri and Behzad Kiani
    Citation: BMC Cancer 2020 20:1170
    Content type: Research article Published on:

  41. The aim of the current study was to evaluate oncologic outcomes of patients who were treated with salvage hysterectomy (HT), compared to systemic chemotherapy (CT) for persistent cervical cancer after definiti...

    Authors: Munetaka Takekuma, Fumiaki Takahashi, Seiji Mabuchi, Wataru Kudaka, Koji Horie, Mariko Ikeda, Ayumi Shikama, Akira Mitsuhashi, Shoji Nagao, Shiro Suzuki, Mika Mizuno, Shin Nishio, Hideki Tokunaga, Yukinobu Ota, Takahiro Kasamatsu, Ryo Kitagawa…
    Citation: BMC Cancer 2020 20:1169
    Content type: Research article Published on:

  42. Competing risk method has not been used in a large-scale prospective study to investigate whether increased levels of high-sensitivity C-reactive protein (hs-CRP) elevate the risk of primary liver cancer (PLC)...

    Authors: Sarah Tan Siyin, Tong Liu, Wenqiang Li, Nan Yao, Guoshuai Xu, Jun Qu and Yajun Chen
    Citation: BMC Cancer 2020 20:1168
    Content type: Research article Published on:

  43. An increasing number of studies have focused on the association between leptin, adiponectin levels and the risk as well as the prognosis of hepatocellular carcinoma. However, the reported results are conflicting.

    Authors: Lilong Zhang, Qihang Yuan, Man Li, Dongqi Chai, Wenhong Deng and Weixing Wang
    Citation: BMC Cancer 2020 20:1167
    Content type: Research article Published on:

  44. Papillary thyroid cancer (PTC) is unique among cancers in that patient age is a consideration in staging. One of the most important modifications in the 8th Edition of the American Joint Committee on Cancer (A...

    Authors: Krzysztof Kaliszewski, Dorota Diakowska, Łukasz Nowak, Beata Wojtczak and Jerzy Rudnicki
    Citation: BMC Cancer 2020 20:1166
    Content type: Research article Published on:

  45. The primary aim was to test the hypothesis that deriving pre-treatment 3D magnetic resonance tumour volume (mrTV) quantification improves performance characteristics for the prediction of loco-regional failure...

    Authors: Hema Sekhar, Rohit Kochhar, Bernadette Carrington, Thomas Kaye, Damian Tolan, Mark P. Saunders, Matthew Sperrin, David Sebag-Montefiore, Marcel van Herk and Andrew G. Renehan
    Citation: BMC Cancer 2020 20:1165
    Content type: Research article Published on:

  46. Preoperative chemoradiotherapy with capecitabine is considered as a standard of care for locally advanced rectal cancer. The “Tratamiento de Tumores Digestivos” group (TTD) previously reported in a randomized ...

    Authors: Ramón Salazar, Jaume Capdevila, Jose Luis Manzano, Carles Pericay, Mercedes Martínez-Villacampa, Carlos López, Ferrán Losa, María José Safont, Auxiliadora Gómez-España, Vicente Alonso-Orduña, Pilar Escudero, Javier Gallego, Beatriz García-Paredes, Amalia Palacios, Sebastiano Biondo, Cristina Grávalos…
    Citation: BMC Cancer 2020 20:1164
    Content type: Research article Published on:

  47. Aggressive systemic mastocytosis (ASM) is a rare malignant disease characterized by disordered mast cell accumulation in various organs. We here describe a female ASM patient with a previous history of ovarian...

    Authors: Makiko Tsutsumi, Hiroki Miura, Hidehito Inagaki, Yasuko Shinkai, Asuka Kato, Takema Kato, Susumu Hamada-Tsutsumi, Makito Tanaka, Kazuko Kudo, Tetsushi Yoshikawa and Hiroki Kurahashi
    Citation: BMC Cancer 2020 20:1162
    Content type: Research article Published on:

  48. Surgical resection is the major way to cure pancreatic ductal adenocarcinoma (PDAC). However, this operation is complex, and the peri-operative risk is high, making patients more likely to be admitted to the i...

    Authors: Yijue Zhang, Sibo Zhu, Zhiqing Yuan, Qiwei Li, Ruifeng Ding, Xunxia Bao, Timing Zhen, Zhiliang Fu, Hailong Fu, Kaichen Xing, Hongbin Yuan and Tao Chen
    Citation: BMC Cancer 2020 20:1161
    Content type: Research article Published on:

  49. Despite advances in early diagnosis and treatment, cancer remains the leading cause of mortality worldwide. The insulin-like growth factor 2 mRNA binding protein (IGF2BP) family has been reported to be involve...

    Authors: Xiao-Han Cui, Shu-Yi Hu, Chun-Fu Zhu and Xi-Hu Qin
    Citation: BMC Cancer 2020 20:1160
    Content type: Research article Published on:

  50. Strong evidences support the critical role of Jumonji domain containing 6 (JMJD6) in progression of breast cancer. Here we explore potential partners that coregulate gene expression, to understand additional p...

    Authors: Antara Biswas, Geetashree Mukherjee, Paturu Kondaiah and Kartiki V. Desai
    Citation: BMC Cancer 2020 20:1159
    Content type: Research article Published on:

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