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  1. Endoscopic submucosal dissection (ESD) is gaining enormous popularity in the treatment of early gastric cancers (EGCs) in many institutions across the world. However, appropriate selection of candidates for en...

    Authors: Kidane Siele Embaye, Chao Zhang, Matiwos Araya Ghebrehiwet, Zhihao Wang, Fengdi Zhang, Liwei Liu, Shenghui Qin, Lingzhi Qin, Jun Wang and Xi Wang
    Citation: BMC Cancer 2021 21:92
    Content type: Research article Published on:

  2. Giant cell tumor of bone (GCTB) is a rare osteoclastogenic stromal tumor. GCTB can rarely undergo malignant transformation. This post hoc analysis evaluated and classified malignancies in patients with GCTB wh...

    Authors: Emanuela Palmerini, Leanne L. Seeger, Marco Gambarotti, Alberto Righi, Peter Reichardt, Susan Bukata, Jean-Yves Blay, Tian Dai, Danielle Jandial and Piero Picci
    Citation: BMC Cancer 2021 21:89
    Content type: Research article Published on:

  3. Despite reports of a link between human papillomavirus (HPV) infection and mechanistic target of rapamycin (mTOR) signaling activation, the role of the mTOR pathway, especially raptor and rictor, in HPV-relate...

    Authors: Shunsuke Kondo, Hitoshi Hirakawa, Taro Ikegami, Takayuki Uehara, Shinya Agena, Jin Uezato, Hidetoshi Kinjyo, Noritomo Kise, Yukashi Yamashita, Katsunori Tanaka, Narumi Hasegawa, Asanori Kiyuna, Hiroyuki Maeda, Mikio Suzuki and Akira Gahana
    Citation: BMC Cancer 2021 21:87
    Content type: Research article Published on:

  5. Serum bilirubin and total bile acid (TBA) levels have been reported to be strongly associated with the risk and prognosis of certain cancers. Here, we aimed to investigate the effects of pretreatment levels of...

    Authors: Yinghao Cao, Shenghe Deng, Lizhao Yan, Junnan Gu, Jia Yang, Ming Yang, Li Liu and Kailin Cai
    Citation: BMC Cancer 2021 21:85
    Content type: Research article Published on:

  6. The successful transition of childhood cancer survivors (CCSs) from pediatric to adult long-term follow-up care is a critical phase, and determining the right time point can be challenging. We assessed the fea...

    Authors: Maria Otth, Patrick Wechsler, Sibylle Denzler, Henrik Koehler and Katrin Scheinemann
    Citation: BMC Cancer 2021 21:84
    Content type: Research article Published on:

  7. Non-invasive diagnosis of IDH1 mutation for gliomas has great clinical significance, and PET has natural advantage to detect metabolism, as IDH mutated gliomas share lower glucose consumption.

    Authors: Feng-Min Liu, Yu-fei Gao, Yanyan Kong, Yihui Guan, Jinsen Zhang, Shuai-Hong Li, Dan Ye, Wenyu Wen, Chuantao Zuo and Wei Hua
    Citation: BMC Cancer 2021 21:83
    Content type: Research article Published on:

  8. BCOR acts as a corepressor of BCL6, a potent oncogenic protein in cancers of the lymphoid lineage. We have found the recurrent somatic mutation of BCOR occurred in mature T-cell lymphoma (TCL). The role of BCO...

    Authors: Jin Hyun Kang, Seung Ho Lee, Jawon Lee, Murim Choi, Junhun Cho, Seok Jin Kim, Won Seog Kim, Young Hyeh Ko and Hae Yong Yoo
    Citation: BMC Cancer 2021 21:82
    Content type: Research article Published on:

  9. Glioblastoma (GBM) is a highly malignant brain tumor with poor survival and prognosis. Randomized trials have demonstrated that chemotherapy improves survival in patients with GBM. This study aims to examine t...

    Authors: Jieqiong Wen, Wanbin Chen, Yayun Zhu and Pengbo Zhang
    Citation: BMC Cancer 2021 21:81
    Content type: Research article Published on:

  10. A high incidence of upper urinary tract urothelial carcinoma has been reported in the southwestern area of Taiwan, where arsenic water contamination was considered the main cause. However, there is no definite...

    Authors: Che-Wei Chang, Chien-Hui Ou, Chih-Chin Yu, Chi-Wen Lo, Chung-You Tsai, Pai-Yu Cheng, Yung-Tai Chen, Hsu-Che Huang, Chia-Chang Wu, Ching-Chia Li and Hsiang-Ying Lee
    Citation: BMC Cancer 2021 21:80
    Content type: Research article Published on:

  11. Clear cell renal cell carcinoma (ccRCC) is one of the most frequent malignancies; however, the present prognostic factors was deficient. This study aims to explore whether there is a relationship between tumor...

    Authors: Shao-Hao Chen, Long-Yao Xu, Yu-Peng Wu, Zhi-Bin Ke, Peng Huang, Fei Lin, Xiao-Dong Li, Xue-Yi Xue, Yong Wei, Qing-Shui Zheng and Ning Xu
    Citation: BMC Cancer 2021 21:79
    Content type: Research article Published on:

  12. The role of capecitabine in neoadjuvant and adjuvant chemotherapy for early-stage triple-negative breast cancer (TNBC) is highly controversial. Our meta-analysis was designed to further elucidate the effects o...

    Authors: Xingfa Huo, Jinming Li, Fuxing Zhao, Dengfeng Ren, Raees Ahmad, Xinyue Yuan, Feng Du and Jiuda Zhao
    Citation: BMC Cancer 2021 21:78
    Content type: Research article Published on:

  13. To investigate the clinical impact of sarcopenia and skeletal muscle density (SMD) among patients with metastatic pancreatic adenocarcinoma who underwent palliative first line gemcitabine-based chemotherapy.

    Authors: In-Ho Kim, Moon Hyung Choi, In Seok Lee, Tae Ho Hong and Myung Ah. Lee
    Citation: BMC Cancer 2021 21:77
    Content type: Research article Published on:

  14. Breast cancer is the most frequently diagnosed malignancy among women. However, the role of microRNA (miRNA) expression in breast cancer progression is not fully understood. In this study we examined predictiv...

    Authors: Adriane F. Evangelista, Renato J. Oliveira, Viviane A. O. Silva, Rene A. D. C. Vieira, Rui M. Reis and Marcia M. C. Marques
    Citation: BMC Cancer 2021 21:76
    Content type: Research article Published on:

  15. A serious syndrome for cancer in-patients, delirium risk increases with age and medical acuity. Screening tools exist but detection is frequently delayed or missed. We test the ‘Single Question in Delirium’ (S...

    Authors: Megan B. Sands, Swapnil Sharma, Lindsay Carpenter, Andrew Hartshorn, Jessica T. Lee, Sanja Lujic, Megan E. Congdon, Angus M. Buchanan, Meera Agar and Janette L. Vardy
    Citation: BMC Cancer 2021 21:75
    Content type: Research article Published on:

  16. Patients with lung cancer who are treated with carboplatin-based chemotherapy regimens often experience chemotherapy-induced nausea and vomiting (CINV). However, knowledge on the effect of regimen and cofactor...

    Authors: Toshinobu Hayashi, Mototsugu Shimokawa, Koichi Matsuo, Hirotoshi Iihara, Kei Kawada, Takafumi Nakano and Takashi Egawa
    Citation: BMC Cancer 2021 21:74
    Content type: Research article Published on:

  17. We have performed a head to head comparison of all-oral triplet combination of ixazomib, lenalidomide and dexamethasone (IRD) versus lenalidomide and dexamethasone (RD) in patients with relapsed and refractory...

    Authors: Jiri Minarik, Tomas Pika, Jakub Radocha, Alexandra Jungova, Jan Straub, Tomas Jelinek, Ludek Pour, Petr Pavlicek, Martin Mistrik, Lucie Brozova, Petra Krhovska, Katerina Machalkova, Pavel Jindra, Ivan Spicka, Hana Plonkova, Martin Stork…
    Citation: BMC Cancer 2021 21:73
    Content type: Research article Published on:

  18. p-Boronophenylalanine (10BPA) is a powerful 10B drug used in current clinical trials of BNCT. For BNCT to be successful, a high (500 mg/kg) dose of 10BPA must be administered over a few hours. Here, we report BNC...

    Authors: Tohru Yoneyama, Shingo Hatakeyama, Mihoko Sutoh Yoneyama, Taku Yoshiya, Tsuyoshi Uemura, Takehiro Ishizu, Minoru Suzuki, Shingo Hachinohe, Shintaro Ishiyama, Motohiro Nonaka, Michiko N. Fukuda and Chikara Ohyama
    Citation: BMC Cancer 2021 21:72
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2021 21:105

  19. Breast cancer is the second most common causes of women’s death, worldwide. Data on risk factors associated with female breast cancer in the Afghan population is very limited. The aim of our study was to ident...

    Authors: Zekrullah Baset, Jamshid Abdul-Ghafar, Yasmin Nadeem Parpio and Ahmed Maseh Haidary
    Citation: BMC Cancer 2021 21:71
    Content type: Research article Published on:

  20. Use of statins is associated with a reduced risk of hepatocellular carcinoma (HCC). However, the effect of statin use on HCC recurrence is unclear. This study aimed to evaluate the effect of statin use on recu...

    Authors: Shih-Yu Yang, Chih-Chi Wang, Kuang-Den Chen, Yueh-Wei Liu, Chih-Che Lin, Ching-Hui Chuang, Yu-Chieh Tsai, Chih-Chien Yao, Yi-Hao Yen, Chang-Chun Hsiao, Tsung-Hui Hu and Ming-Chao Tsai
    Citation: BMC Cancer 2021 21:70
    Content type: Research article Published on:

  22. This study was aimed to explore the predictive ability of tumor infiltrating neutrophil (TIN) in patients with breast cancer treated with neoadjuvant chemotherapy (NACT). Furthermore, the significance of TIN’s...

    Authors: Sheng-Kai Geng, Shao-Mei Fu, Shi-Hong Ma, Yi-Peng Fu and Hong-Wei Zhang
    Citation: BMC Cancer 2021 21:68
    Content type: Research article Published on:

  23. The role of nicotinamide N-methyltransferase (NNMT) in ovarian cancer is still elusive. Our aim is to explore the expression of NNMT in ovarian cancer and to assess its association with patient prognosis and t...

    Authors: Jun Li, Huiran Yue, Hailin Yu, Xin Lu and Xiaohong Xue
    Citation: BMC Cancer 2021 21:67
    Content type: Research article Published on:

  24. We evaluated the prognostic potential of tumor 18F-fluorodeoxyglucose (FDG) uptake derived from positron emission tomography (PET) and known inflammatory hematological markers, both individually and in combinatio...

    Authors: Kewei Zhao, Chunsheng Wang, Fang Shi, Yong Huang, Li Ma, Minghuan Li and Yipeng Song
    Citation: BMC Cancer 2021 21:66
    Content type: Research article Published on:

  25. Chemoresistance is one of the main problems in treatment of cancer. Periostin (PN) is a stromal protein which is mostly secreted from cancer associated fibroblasts in the tumor microenvironment and can promote...

    Authors: Khine Kyaw Oo, Thanpawee Kamolhan, Anish Soni, Suyanee Thongchot, Chalermchai Mitrpant, Pornchai O-charoenrat, Chanitra Thuwajit and Peti Thuwajit
    Citation: BMC Cancer 2021 21:65
    Content type: Research article Published on:

  26. Outcomes are poorer in metastatic colorectal cancer (mCRC) patients with BRAF V600E mutations than those without it, but the effect of these mutations on treatment response is unclear. This real-world study asses...

    Authors: Nieves Martínez-Lago, Ana Fernández-Montes, Marta Covela, Elena M. Brozos, Juan De la Cámara, José C. Méndez Méndez, Mónica Jorge-Fernández, Antía Cousillas Castiñeiras, Cristina Reboredo, David Arias Ron, María L. Pellón Augusto, Paula González Villarroel, Begoña Graña, Mercedes Salgado Fernández, Alberto Carral Maseda, Francisca Vázquez Rivera…
    Citation: BMC Cancer 2021 21:64
    Content type: Research article Published on:

  28. The superior accuracy and sensitivity of 18F-FDG-PET/CT in comparison to morphological imaging alone leads to an upstaging in up to 30% of lymphoma patients. Novel digital PET/CT scanners might enable to reduce a...

    Authors: Manuel Weber, Walter Jentzen, Regina Hofferber, Ken Herrmann, Wolfgang Peter Fendler, Christoph Rischpler, Lale Umutlu, Maurizio Conti, Pedro Fragoso Costa, Miriam Sraieb and David Kersting
    Citation: BMC Cancer 2021 21:62
    Content type: Research article Published on:

  29. Prostate cancer among black men is known to have specific molecular characteristics, especially the androgen receptor or enzymes related to the androgen metabolism. These targets are keys to the action of new ...

    Authors: Matthias E. Meunier, Pascal Blanchet, Yann Neuzillet, Thierry Lebret and Laurent Brureau
    Citation: BMC Cancer 2021 21:61
    Content type: Research article Published on:

  31. The prognosis of childhood acute lymphoblastic leukemia (ALL) is optimistic with a 5-year event-free survival (EFS) rate of 70–85%. However, the major causes of mortality are chemotherapy toxicity, infection a...

    Authors: Xin-Yu Li, Jia-Qiang Li, Xue-Qun Luo, Xue-Dong Wu, Xin Sun, Hong-Gui Xu, Chang-Gang Li, Ri-Yang Liu, Xiao-Fei Sun, Hui-Qin Chen, Yu-Deng Lin, Chi-kong LI and Jian-Pei Fang
    Citation: BMC Cancer 2021 21:59
    Content type: Research article Published on:

  32. Autophagy-related genes (ARGs) have been confirmed to have an important role in tumorigenesis and tumor microenvironment formation. Nevertheless, a systematic analysis of ARGs and their clinical significance i...

    Authors: Yuanhe Wang, Jianyi Li, Cheng Shao, Xiaojie Tang, Yukun Du, Tongshuai Xu, Zheng Zhao, Huiqiang Hu, Yingyi Sheng, Chuan Hu and Yongming Xi
    Citation: BMC Cancer 2021 21:58
    Content type: Research article Published on:

  33. Cell-free DNA (cfDNA) genotyping in plasma using the cobas EGFR Mutation Test v2 (cobas) is the first liquid biopsy as a companion diagnosis to identify the EGFR T790M mutation (T790M) after the failure of tre...

    Authors: Yuko Oya, Tatsuya Yoshida, Kazuhiro Asada, Tetsuya Oguri, Naoki Inui, Sayako Morikawa, Kentaro Ito, Tomoki Kimura, Eiji Kunii, Takashi Matsui, Akihito Kubo, Tatsuo Kato, Takashi Abe, Takeshi Tsuda and Toyoaki Hida
    Citation: BMC Cancer 2021 21:57
    Content type: Research article Published on:

  34. Surgery is the only treatment option for operable gastric cancer. The CLASSIC and ACTS-GC studies showed that the 5-year overall survival (OS) of patients with stage III gastric cancer undergoing D2 gastrectom...

    Authors: Xiangdong Cheng, Dan Wu, Nong Xu, Luchuan Chen, Zhilong Yan, Ping Chen, Lei Zhou, Jianfa Yu, Jiuwei Cui, Wei Li, Chang Wang, Wenming Feng, Yunhai Wei, Pengfei Yu, Yian Du, Jieer Ying…
    Citation: BMC Cancer 2021 21:56
    Content type: Study protocol Published on:

  37. Prognosis for pediatric metastatic Retinoblastoma (Rb) is poor and current therapies are limited by high systemic toxicity rates and insufficient therapeutic efficacy for metastatic Rb. Tumor dissemination to ...

    Authors: Jonathan Guihurt Santiago, Neikelyn Burgos-Tirado, Daniella Dorta Lafontaine, José C. Mendoza Sierra, Roberto Herrera Camacho, Clara M. Vecchini Rodríguez, Vanessa Morales-Tirado and Jacqueline Flores-Otero
    Citation: BMC Cancer 2021 21:53
    Content type: Research article Published on:

  38. Epidermal growth factor receptor (EGFR) mutations in non–small-cell lung cancer predict sensitivity to EGFR tyrosine kinase inhibitors (TKIs). EGFR mutation types are associated with efficacy of EGFR TKIs. We inv...

    Authors: Sojung Park, Sung Yong Lee, Dojin Kim, Yun Su Sim, Jeong-Seon Ryu, Juwhan Choi, Su Hwan Lee, Yon Ju Ryu, Jin Hwa Lee and Jung Hyun Chang
    Citation: BMC Cancer 2021 21:52
    Content type: Research article Published on:

  39. Bladder cancer is the ninth most common type of cancer worldwide. In the past, radical cystectomy via open surgery has been considered the gold-standard treatment for muscle invasive bladder cancer. However, i...

    Authors: Angelo Porreca, Katie Palmer, Walter Artibani, Alessandro Antonelli, Lorenzo Bianchi, Eugenio Brunocilla, Aldo Massimo Bocciardi, Maurizio Brausi, Gian Maria Busetto, Marco Carini, Giuseppe Carrieri, Antonio Celia, Luca Cindolo, Giovanni Cochetti, Renzo Colombo, Ettore De Berardinis…
    Citation: BMC Cancer 2021 21:51
    Content type: Study protocol Published on:

  40. Despite much research published on lung cancer screening, China has had no large-scale study on the missed diagnosis of lung cancer in a health examination population. We therefore did a real-world study using...

    Authors: Guiyi Ji, Ting Bao, Zhenzhen Li, Huairong Tang, Dan Liu, Ping Yang, Weimin Li and Yan Huang
    Citation: BMC Cancer 2021 21:50
    Content type: Research article Published on:

  41. Novel biomarkers and molecular monitoring tools hold potential to improve outcome for patients following resection of pancreatic ductal adenocarcinoma (PDAC). We hypothesized that the combined longitudinal ana...

    Authors: Saskia Hussung, Dilara Akhoundova, Julian Hipp, Marie Follo, Rhena F. U. Klar, Ulrike Philipp, Florian Scherer, Nikolas von Bubnoff, Justus Duyster, Melanie Boerries, Uwe Wittel and Ralph M. Fritsch
    Citation: BMC Cancer 2021 21:49
    Content type: Research article Published on:

  42. Cisplatin-based chemotherapy is recommended as the primary treatment for advanced bladder cancer (BC) with unresectable or metastatic disease. However, the benefits are limited due to the acquisition of drug r...

    Authors: Shunsuke Okamura, Hirofumi Yoshino, Kazuki Kuroshima, Masafumi Tsuruda, Yoichi Osako, Takashi Sakaguchi, Masaya Yonemori, Yasutoshi Yamada, Shuichi Tatarano, Masayuki Nakagawa and Hideki Enokida
    Citation: BMC Cancer 2021 21:48
    Content type: Research article Published on:

  43. Neoadjuvant chemotherapy (NACT) is the prime approach to the management of locally advanced breast cancer (LABC). Influenced by different factors such as pathologic tumor characteristics, hormone receptor stat...

    Authors: Dena Firouzabadi, Amirreza Dehghanian, Alireza Rezvani, Laleh Mahmoudi and Abdolrasoul Talei
    Citation: BMC Cancer 2021 21:47
    Content type: Research article Published on:

  44. Although arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) are well-tolerated and effective treatments for Acute Promyelocytic Leukemia (APL), Differentiation Syndrome (DS) is a lethal side effect in s...

    Authors: Zahra Mohammadzadeh, Azadeh Omidkhoda, Bahram Chahardouli, Ghazaleh Hoseinzadeh, Kamran Ali Moghaddam, Seyed Asadollah Mousavi and Shahrbano Rostami
    Citation: BMC Cancer 2021 21:46
    Content type: Research article Published on:

  45. Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome. Comparison of prognosis between LS and sporadic CRC (SCRC) were rare, with conflicting results. This study aimed to compare t...

    Authors: Yun Xu, Cong Li, Charlie Zhi-Lin Zheng, Yu-Qin Zhang, Tian-An Guo, Fang-Qi Liu and Ye Xu
    Citation: BMC Cancer 2021 21:45
    Content type: Research article Published on:

  46. lncRNAs have important roles in regulating cancer biology. Accumulating evidence has established a link between the dysregulation of lncRNAs and microRNA in cancer progression. In previous studies, miR-7-5p has b...

    Authors: Gwan Woo Ku, Yujin Kang, Seong-Lan Yu, Joonghoon Park, Sejin Park, In Beom Jeong, Min Woong Kang, Ji Woong Son and Jaeku Kang
    Citation: BMC Cancer 2021 21:44
    Content type: Research article Published on:

  47. Surgical resection remains the only curative treatment for pancreatic cancer and is associated with significant post-operative morbidity and mortality. Patients eligible for surgery, increasingly receive neo-a...

    Authors: Dominic O’Connor, Malcolm Brown, Martin Eatock, Richard C. Turkington and Gillian Prue
    Citation: BMC Cancer 2021 21:43
    Content type: Research article Published on:

  48. In contrast to the rapid increase in thyroid cancer incidence, the mortality has remained low and stable over the last decades. In Ecuador, however, thyroid cancer mortality has increased. The objective of thi...

    Authors: Paola Solis-Pazmino, Jorge Salazar-Vega, Eddy Lincango-Naranjo, Cristhian Garcia, Gabriela Jaramillo Koupermann, Esteban Ortiz-Prado, Tannya Ledesma, Tatiana Rojas, Benjamin Alvarado-Mafla, Cesar Carcamo, Oscar J. Ponce and Juan P. Brito
    Citation: BMC Cancer 2021 21:42
    Content type: Research article Published on:

  49. The aim of our study was to evaluate the cost-effectiveness of cabazitaxel versus abiraterone or enzalutamide in patients with metastatic castration-resistant prostate cancer (mCRPC) previously treated with do...

    Authors: Peng-Fei Zhang, Dan Xie and Qiu Li
    Citation: BMC Cancer 2021 21:35
    Content type: Research article Published on:

  50. An upgraded understanding of factors (sex/estrogen) associated with survival benefit in advanced colorectal carcinoma (CRC) could improve personalised management and provide innovative insights into anti-tumou...

    Authors: Chunlong Huang, Xiaoyuan Gu, Xianshang Zeng, Baomin Chen, Weiguang Yu and Meiji Chen
    Citation: BMC Cancer 2021 21:30
    Content type: Research article Published on:

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