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  1. The gut microbiota influences many aspects of host physiology, including immune regulation, and is predictive of outcomes in cancer patients. However, whether conventional myelosuppressive chemotherapy affects...

    Authors: Lito E. Papanicolas, Sarah K. Sims, Steven L. Taylor, Sophie J. Miller, Christos S. Karapetis, Steve L. Wesselingh, David L. Gordon and Geraint B. Rogers
    Citation: BMC Cancer 2021 21:591
    Content type: Research article Published on:

  2. Obesity and other metabolic comorbidities affect over 10% of patients with breast cancer and are closely related with adverse outcomes. Although metabolic comorbidities among breast cancer patients in low- and...

    Authors: Sumadi Lukman Anwar, Roby Cahyono, Dayat Prabowo, Widya Surya Avanti, Lina Choridah, Ery Kus Dwianingsih, Wirsma Arif Harahap and Teguh Aryandono
    Citation: BMC Cancer 2021 21:590
    Content type: Research article Published on:

  3. Aldehyde dehydrogenase 2 (ALDH2) plays an important role in the endogenous aldehyde detoxification of various types of cells. ALDH2*2, a variant allele of the ALDH2 polymorphism rs671, leads to decreased enzymati...

    Authors: Akiko Matsumoto, Chiho Nakashima, Shinya Kimura, Eizaburo Sueoka and Naoko Aragane
    Citation: BMC Cancer 2021 21:584
    Content type: Research Published on:

  7. Neuroendocrine tumors, although relatively rare in incidence, are now the second most prevalent gastrointestinal neoplasm owing to indolent disease biology. A small but significant sub-group of neuroendocrine ...

    Authors: Aman Chauhan, Satya Das, Rachel Miller, Laura Luque, Samuel N. Cheuvront, James Cloud, Zach Tarter, Fariha Siddiqui, Robert A. Ramirez and Lowell Anthony
    Citation: BMC Cancer 2021 21:580
    Content type: Research article Published on:

  8. It has been shown that a subgroup of patients with differentiated thyroid cancer (DTC) and medullary thyroid carcinoma (MTC) would progress to advanced stages of thyroid cancer. Therefore, the present study wa...

    Authors: Zohreh Maghsoomi, Zahra Emami, Ramin Malboosbaf, Mojtaba Malek and Mohammad E. Khamseh
    Citation: BMC Cancer 2021 21:579
    Content type: Research article Published on:

  9. The viral pandemic coronavirus disease 2019 (COVID-19) has disrupted cancer patient management around the world. Most reported data relate to incidence, risk factors, and outcome of severe COVID-19. The safety...

    Authors: C. van Marcke, N. Honoré, A. van der Elst, S. Beyaert, F. Derouane, C. Dumont, F. Aboubakar Nana, J. F. Baurain, I. Borbath, P. Collard, F. Cornélis, A. De Cuyper, F. P. Duhoux, B. Filleul, R. Galot, M. Gizzi…
    Citation: BMC Cancer 2021 21:578
    Content type: Research article Published on:

  10. PDE9A (Phosphodiesterase 9A) plays an important role in proliferation of cells, their differentiation and apoptosis via intracellular cGMP (cyclic guanosine monophosphate) signaling. The expression pattern of ...

    Authors: Tasmina Ferdous Susmi, Atikur Rahman, Md. Moshiur Rahman Khan, Farzana Yasmin, Md. Shariful Islam, Omaima Nasif, Sulaiman Ali Alharbi, Gaber El-Saber Batiha and Mohammad Uzzal Hossain
    Citation: BMC Cancer 2021 21:577
    Content type: Research Published on:

  11. Malignant gastric outlet obstruction (MGOO) occasionally occurs due to pancreaticobiliary cancer. Endoscopic duodenal stenting (DS) is a common treatment for MGOO. However, it has been reported that DS does no...

    Authors: Satoshi Kobayashi, Makoto Ueno, Shuhei Nagashima, Yusuke Sano, Kuniyuki Kawano, Taito Fukushima, Hiroyuki Asama, Shun Tezuka and Manabu Morimoto
    Citation: BMC Cancer 2021 21:576
    Content type: Research Published on:

  12. No biomarker is available for identifying cancer patients at risk of developing nephrotoxicity when treated with cisplatin.

    Authors: Julia C. F. Quintanilha, Maria A. Cursino, Jessica B. Borges, Nadine G. Torso, Larissa B. Bastos, Juliana M. Oliveira, Thiago S. Cobaxo, Eder C. Pincinato, Mario H. Hirata, Murilo V. Geraldo, Carmen S. P. Lima and Patricia Moriel
    Citation: BMC Cancer 2021 21:575
    Content type: Research article Published on:

  13. Authors: Ulrich Jarry, Mégane Bostoën, Raphaël Pineau, Laura Chaillot, Valentine Mennessier, Pierre Montagne, Emilie Motte, Marjorie Gournay, Arnaud Le Goff, Thierry Guillaudeux and Rémy Pedeux
    Citation: BMC Cancer 2021 21:574
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2021 21:530

  14. The routine clinical use of serum prostatic specific antigen (PSA) testing has allowed earlier detection of low-grade prostate cancer (PCa) with more favourable characteristics, leading to increased acceptance...

    Authors: Salonee Shah, Kerri Beckmann, Mieke Van Hemelrijck, Ben Challacombe, Rick Popert, Prokar Dasgupta, Jonah Rusere, Grace Zisengwe, Oussama Elhage and Aida Santaolalla
    Citation: BMC Cancer 2021 21:573
    Content type: Database Published on:

    The Correction to this article has been published in BMC Cancer 2022 22:97

  15. Pregnancy-associated breast cancer (PABC) defined as breast cancer diagnosed during gestation, lactation or within 1 year after delivery, represents a truly challenging situation with significantly increasing ...

    Authors: Eleni Zografos, Anna-Maria Korakiti, Angeliki Andrikopoulou, Ioannis Rellias, Constantine Dimitrakakis, Spyridon Marinopoulos, Aris Giannos, Antonios Keramopoulos, Nikolaos Bredakis, Meletios-Athanasios Dimopoulos and Flora Zagouri
    Citation: BMC Cancer 2021 21:572
    Content type: Research Published on:

  16. The mechanism of small-molecule stabilised protein-protein interactions is of growing interest in the pharmacological discovery process. A plethora of different substances including the aromatic sulphonamide E...

    Authors: Michael David Hülskamp, Daniel Kronenberg and Richard Stange
    Citation: BMC Cancer 2021 21:571
    Content type: Research Published on:

  17. Adjuvant endocrine therapies are known to induce undesirable adverse effects such as vasomotor, vaginal and musculoskeletal symptoms among breast cancer patients. Drugs used in these therapies are often metabo...

    Authors: Carmen W. H. Chan, Bernard M. H. Law, Marques S. N. Ng, Corinna C. Y. Wong, Carissa W. Y. Wong, Morgan Quinley, Jessica M. Orgusyan, Ka Ming Chow and Mary M. Y. Waye
    Citation: BMC Cancer 2021 21:570
    Content type: Research article Published on:

  18. Regorafenib has shown promising results as a second-line therapy for patients with hepatocellular carcinoma (HCC) who progressed on sorafenib. Although there have been several data regarding the efficacy of se...

    Authors: Young Mi Hong, K. T. Yoon and Mong Cho
    Citation: BMC Cancer 2021 21:569
    Content type: Research article Published on:

  19. Triple-negative breast cancer (TNBC) is a heterogeneous disease and we have previously shown that rapid relapse of TNBC is associated with distinct sociodemographic features. We hypothesized that rapid versus ...

    Authors: Yiqing Zhang, Sarah Asad, Zachary Weber, David Tallman, William Nock, Meghan Wyse, Jerome F. Bey, Kristin L. Dean, Elizabeth J. Adams, Sinclair Stockard, Jasneet Singh, Eric P. Winer, Nancy U. Lin, Yi-Zhou Jiang, Ding Ma, Peng Wang…
    Citation: BMC Cancer 2021 21:568
    Content type: Research Published on:

  20. Primary hepatic neuroendocrine tumors (PH-NETs) are extremely rare and unknown. Because of its rarity, its prognosis features and influencing factors are not well established.

    Authors: Ziteng Zhang, Xin Zhao, Zhiyan Li, Youchun Wu, Yao Liu, Zhiwei Li and Guobao Li
    Citation: BMC Cancer 2021 21:567
    Content type: Research Published on:

  21. Significant progress has been made in the treatment outcomes of mantle cell lymphoma (MCL) since the introduction of cytarabine and rituximab in modern regimens. However, older patients may not readily tolerat...

    Authors: Xinyi Yang, Lay Poh Khoo, Esther Wei Yin Chang, Valerie Shiwen Yang, Eileen Poon, Nagavalli Somasundaram, Mohamad Farid, Tiffany Pooi Ling Tang, Miriam Tao, Soon Thye Lim and Jason Yongsheng Chan
    Citation: BMC Cancer 2021 21:566
    Content type: Research article Published on:

  22. Metaplastic breast cancer (MBC) is a rare subtype of breast cancer, and generally associated with poor outcomes. Lymph nodes metastasis (LNM) is confirmed as a critical independent prognostic factor and determ...

    Authors: Mi Zhang, Biyuan Wang, Na Liu, Hui Wang, Juan Zhang, Lei Wu, Andi Zhao, Le Wang, Xiaoai Zhao and Jin Yang
    Citation: BMC Cancer 2021 21:565
    Content type: Research article Published on:

  23. The chemotherapy triplet FOLFOXIRI combined to the anti-VEGF antibody bevacizumab is an option in selected patients with metastatic colorectal cancer. In this setting, RAS-mutated metastatic colorectal cancer ...

    Authors: Antoine Adenis, Thibault Mazard, Julien Fraisse, Patrick Chalbos, Brice Pastor, Ludovic Evesque, Francois Ghiringhelli, Caroline Mollevi, Stéphanie Delaine and Marc Ychou
    Citation: BMC Cancer 2021 21:564
    Content type: Study protocol Published on:

  25. Percutaneous magnetic resonance-guided (MR-guided) MWA procedures have traditionally been performed under local anesthesia (LA) and sedation. However, pain control is often difficult to manage, especially in s...

    Authors: Zhaonan Li, Chaoyan Wang, Jing Li, Zaoqu Liu, Dechao Jiao and Xinwei Han
    Citation: BMC Cancer 2021 21:562
    Content type: Research article Published on:

  26. Oral Potentially Malignant Disorders (OPMD) have a non-negligible malignant transformation rate of up to 8%. Loss of heterozygosity (LOH) in critical chromosomal loci has proven to be the most effective marker...

    Authors: Cristina Gurizzan, Luigi Lorini, Alberto Paderno, Michele Tomasoni, Gabriele Zigliani, Anna Bozzola, Laura Ardighieri, Simonetta Battocchio, Eliana Bignotti, Antonella Ravaggi, Chiara Romani, Loris De Cecco, Mara Serena Serafini, Rosalba Miceli, Elena Bardellini, Alessandra Majorana…
    Citation: BMC Cancer 2021 21:561
    Content type: Study protocol Published on:

  28. As an H3K27me3 demethylase and counteracts polycomb-mediated transcription repression, KDM6B has been implicated in the development and malignant progression in various types of cancers. However, its potential...

    Authors: Mei Qin, Fei Han, Jian Wu, Feng-xia Gao, Yuan Li, De-xin Yan, Xue-mei He, Yang Long, Xiao-ping Tang, De-lian Ren, Yan Gao and Tian-yang Dai
    Citation: BMC Cancer 2021 21:559
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2021 21:893

  29. Noggin and RNA-binding protein for multiple splicing 2 (RBPMS2) are known to regulate the expression of smooth muscle cells, endothelial cells, and osteoblasts. However, the prognostic role of combined Noggin ...

    Authors: Sang Hoon Chun, Eun Young Kim, Jung-Sook Yoon, Hye Sung Won, Kwangil Yim, Hye Won Hwang, Soon Auck Hong, Minho Lee, Su Lim Lee, Sung-Soo Kim, Der Sheng Sun and Yoon Ho Ko
    Citation: BMC Cancer 2021 21:558
    Content type: Research article Published on:

  30. Comorbidity has been established as one of the important predictors of poor prognosis in lung cancer. In this study, we analyzed the prevalence of main comorbidities and its association with hospital readmissi...

    Authors: Dawei Zhu, Ruoxi Ding, Yong Ma, Zhishui Chen, Xuefeng Shi and Ping He
    Citation: BMC Cancer 2021 21:557
    Content type: Research article Published on:

  31. The platelet-to-lymphocyte ratio (PLR) and C-reactive protein (CRP) level are markers that have been reported to predict the histological type of various tumors, and here, we evaluated their utility in predict...

    Authors: Rui Chen, Liguang Wang, Qi Zhao, Zhen Li, Man Chen, Guodong Lian and Junyong Zhang
    Citation: BMC Cancer 2021 21:556
    Content type: Research article Published on:

  32. The manner in which bad news is communicated in oncological contexts can affect patients’ engagement, their coping strategies and therapeutic compliance. Although this topic has been broadly investigated since...

    Authors: Ramona Bongelli, Alessia Bertolazzi, Ludovica Piccioni and Roberto Burro
    Citation: BMC Cancer 2021 21:555
    Content type: Research article Published on:

  33. The Will Rogers phenomenon [WRP] describes an apparent improvement in outcome for patients’ group due to tumor grade reclassification. Staging of cancers is important to select appropriate treatment and to est...

    Authors: Mary R. Nittala, Eswar K. Mundra, S. Packianathan, Divyang Mehta, Maria L. Smith, William C. Woods, Shawn McKinney, Barbara S. Craft and Srinivasan Vijayakumar
    Citation: BMC Cancer 2021 21:554
    Content type: Research article Published on:

  35. Little is known about the safety and efficacy of concurrent capecitabine and stereotactic radiotherapy in the setting of breast cancer brain metastases (BCBM).

    Authors: Matthew N. Mills, Afrin Naz, Chetna Thawani, Chelsea Walker, Nicholas B. Figura, Sergiy Kushchayev, Daniel E. Oliver, Arnold B. Etame, Hsiang-Hsuan Michael Yu, Timothy J. Robinson, James K. C. Liu, Michael A. Vogelbaum, Peter A. Forsyth, Brian J. Czerniecki, Hatem H. Soliman, Hyo S. Han…
    Citation: BMC Cancer 2021 21:552
    Content type: Research Published on:

  36. Peripheral blood leukocyte (PBL) DNA methylation may serve as a surrogate marker to evaluate the susceptibility to and prognosis of gastric cancer (GC). In this study, blood-derived DNA methylation levels of t...

    Authors: Chuang Nie, Xu Han, Rongrong Wei, Anastasiia Leonteva, Jia Hong, Xinyu Du, Jing Wang, Lin Zhu, Yashuang Zhao, Yingwei Xue, Haibo Zhou and Wenjing Tian
    Citation: BMC Cancer 2021 21:551
    Content type: Research Published on:

  37. Postoperative pancreatic fistula (POPF) represents the most common complication following pancreaticoduodenectomy (PD). Predictive models are needed to select patients with a high risk of POPF. This study was ...

    Authors: Jian Shen, Feng Guo, Yan Sun, Jingyuan Zhao, Jin Hu, Zunxiang Ke, Yushun Zhang, Xin Jin and Heshui Wu
    Citation: BMC Cancer 2021 21:550
    Content type: Research Published on:

  38. Chemotherapy-induced neutropenia (CIN) has been demonstrated to be a prognostic factor in several cancer conditions. We previously found a significant prognostic value of CIN on overall survival (OS), in a poo...

    Authors: Piera Gargiulo, Laura Arenare, Cesare Gridelli, Alessandro Morabito, Fortunato Ciardiello, Vittorio Gebbia, Paolo Maione, Alessia Spagnuolo, Giuliano Palumbo, Giovanna Esposito, Carminia Maria Della Corte, Floriana Morgillo, Gianfranco Mancuso, Raimondo Di Liello, Adriano Gravina, Clorinda Schettino…
    Citation: BMC Cancer 2021 21:549
    Content type: Research Published on:

  39. Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect of paclitaxel (PTX). There is no known prophylactic measure, although there are some reports of prevention with compression therapy ...

    Authors: Haruru Kotani, Mitsuo Terada, Makiko Mori, Nanae Horisawa, Kayoko Sugino, Ayumi Kataoka, Yayoi Adachi, Naomi Gondou, Akiyo Yoshimura, Masaya Hattori, Masataka Sawaki, Chihoko Takahata, Makiko Kobara and Hiroji Iwata
    Citation: BMC Cancer 2021 21:548
    Content type: Research article Published on:

  40. Photodynamic therapy (PDT) is an anticancer treatment that utilizes the interaction of light and a photosensitiser (PS), promoting tumour cell death mediated by generation of reactive oxygen species. In this s...

    Authors: Pablo Vallecorsa, Gabriela Di Venosa, M. Belén Ballatore, Dario Ferreyra, Leandro Mamone, Daniel Sáenz, Gustavo Calvo, Edgardo Durantini and Adriana Casas
    Citation: BMC Cancer 2021 21:547
    Content type: Research article Published on:

  41. Myelodysplastic syndromes (MDS) is a group of heterogeneous myeloid clonal diseases originating from hematopoietic stem cells. Clinically, elevated mature monocyte in bone marrow is often observed, but its cli...

    Authors: An Wu, Panpan Gao, Ningning Wu, Cong Shi, Zhenya Huang, Chunmeng Rong, Ye Sun, Lixia Sheng, Guifang Ouyang and Qitian Mu
    Citation: BMC Cancer 2021 21:546
    Content type: Research Published on:

  42. Pancreatic ductal adenocarcinoma (PDAC) is still a highly fatal malignancy among the most common cancers. More powerful treatments are expecting to bring hope for patients. Biweekly gemcitabine/nab-paclitaxel/...

    Authors: Chen Chang, Xiaofen Li and Dan Cao
    Citation: BMC Cancer 2021 21:545
    Content type: Study protocol Published on:

  43. One reason for the often late diagnosis of lung cancer (LC) may be that potentially-indicative sensations and symptoms are often diffuse, and may not be considered serious or urgent, making their interpretatio...

    Authors: Adrian Levitsky, Britt-Marie Bernhardson, Ingela Henoch, Maria Olin, Karl Kölbeck, Nadja Rystedt, Carol Tishelman and Lars E. Eriksson
    Citation: BMC Cancer 2021 21:544
    Content type: Research article Published on:

  44. We identified differentiated thyroid cancer (DTC) survivors from SEER registries and performed Poisson regression to calculate the relative risks (RRs) of subsequent malignancies (SMs) by different sites assoc...

    Authors: Xiaoran Mei, Xiaoqin Yao, Fang Feng, Weiwei Cheng and Hui Wang
    Citation: BMC Cancer 2021 21:543
    Content type: Research Published on:

  45. The aim of this study was to evaluate the relationship between pre-treatment plasma fibrinogen (Fib) level and pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in breast cancer patients a...

    Authors: Yihua Wang, Yu Wang, Rui Chen, Zhenrong Tang, Yang Peng, Yudi Jin, Ailin Lan, Nan Ding, Yuran Dai, Linshan Jiang and Shengchun Liu
    Citation: BMC Cancer 2021 21:542
    Content type: Research article Published on:

  46. EpCAM (Epithelial cell adhesion molecule) is often dysregulated in epithelial cancers. Prior studies implicate EpCAM in the regulation of oncogenic signaling pathways and epithelial-to-mesenchymal transition. ...

    Authors: Narendra V. Sankpal, Taylor C. Brown, Timothy P. Fleming, John M. Herndon, Anusha A. Amaravati, Allison N. Loynd and William E. Gillanders
    Citation: BMC Cancer 2021 21:541
    Content type: Research article Published on:

  47. Nasopharyngeal cancer is distinguished from other cancers of the head and neck in its epidemiology, histopathology, clinical characteristics, and therapeutic outcome. Its unique clinico-epidemiologic pattern o...

    Authors: Elizabeth Tadesse Beyene, Siraw Girum Ketema, Assaye Nibret Alebachew, Mizan Yeshanew Saleh and Tsigereda Atumo Gebremariam
    Citation: BMC Cancer 2021 21:540
    Content type: Research Published on:

  48. Undergoing cancer screening is a debatable topic in patients with cognitive impairment. In this study, we aimed to examine the utilization and predictors of breast and colorectal cancer screening among screeni...

    Authors: Shuang Yang, Jiang Bian, Thomas J. George, Karen Daily, Dongyu Zhang, Dejana Braithwaite and Yi Guo
    Citation: BMC Cancer 2021 21:539
    Content type: Research Published on:

  49. At present, the characteristics of mucinous breast carcinoma (MBC) and the factors affecting its prognosis are controversial. We compared the clinical features of MBC with those of infiltrating ductal carcinom...

    Authors: Xingtong Zhou, Zhibo Zheng, Yan Li, Weiwei Zhao, Yan Lin, Jieshi Zhang and Qiang Sun
    Citation: BMC Cancer 2021 21:536
    Content type: Research article Published on:

  50. A pathologically confirmed negative margin is required when performing sublobar resection in patients with early stage peripheral lung adenocarcinoma. However, the optimal margin distance to ensure complete tu...

    Authors: Pan Yin, Bingqing Yue, Ji Zhang, Dong Liu, Dongyu Bai, Guang Zhao, Chutong Huang, Guojun Geng, Jie Jiang, Yongxiang Su, Xiuyi Yu and Jingyu Chen
    Citation: BMC Cancer 2021 21:533
    Content type: Research Published on:

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