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Safety of systemic anti-cancer treatment in oncology patients with non-severe COVID-19: a cohort study



The viral pandemic coronavirus disease 2019 (COVID-19) has disrupted cancer patient management around the world. Most reported data relate to incidence, risk factors, and outcome of severe COVID-19. The safety of systemic anti-cancer therapy in oncology patients with non-severe COVID-19 is an important matter in daily practice.


ONCOSARS-1 was a single-center, academic observational study. Adult patients with solid tumors treated in the oncology day unit with systemic anti-cancer therapy during the initial phase of the COVID-19 pandemic in Belgium were prospectively included. All patients (n = 363) underwent severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) serological testing after the first peak of the pandemic in Belgium. Additionally, 141 of these patients also had a SARS-CoV-2 RT-PCR test during the pandemic. The main objective was to retrospectively determine the safety of systemic cancer treatment, measured by the rate of adverse events according to the Common Terminology Criteria for Adverse Events, in SARS-CoV-2-positive patients compared with SARS-CoV-2-negative patients.


Twenty-two (6%) of the 363 eligible patients were positive for SARS-CoV-2 by RT-PCR and/or serology. Of these, three required transient oxygen supplementation, but none required admission to the intensive care unit. Hematotoxicity was the only adverse event more frequently observed in SARS-CoV-2 -positive patients than in SARS-CoV-2-negative patients: 73% vs 35% (P < 0.001). This association remained significant (odds ratio (OR) 4.1, P = 0.009) even after adjusting for performance status and type of systemic treatment. Hematological adverse events led to more treatment delays for the SARS-CoV-2-positive group: 55% vs 20% (P < 0.001). Median duration of treatment interruption was similar between the two groups: 14 and 11 days, respectively. Febrile neutropenia, infections unrelated to COVID-19, and bleeding events occurred at a low rate in the SARS-CoV-2-positive patients.


Systemic anti-cancer therapy appeared safe in ambulatory oncology patients treated during the COVID-19 pandemic. There were, however, more treatment delays in the SARS-CoV-2-positive population, mainly due to a higher rate of hematological adverse events.

Peer Review reports


The viral pandemic coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), can present broadly, from asymptomatic infection through symptoms of mild general upper respiratory infection, life-threatening acute respiratory distress syndrome, and death [1].

Acute infection is diagnosed by reverse transcription polymerase chain reaction (RT-PCR) allowing the detection of viral RNA from a nasopharyngeal swab. Unfortunately, logistic, financial, and sometimes legal issues precluded during the first wave of the pandemic the vast majority of caregivers around the world, including us, to test patients before each hospital admission, treatment, or diagnostic procedure [2]. Early in the pandemic, specific infection prevention measures and recommendations were implemented in hospitals. These aimed to identify infected patients before they entered the oncology department, protect patients and staff, and maintain treatment quality [3,4,5]. Drastic reductions in cancer diagnosis in the latest months is another dramatic consequence of the pandemic [6].

The majority of scientific data regarding COVID-19 infection in cancer patients relate to the severe form of the disease and focus mainly on incidence, risk factors and outcomes [7,8,9]. Several meta-analyses suggest that cancer patients are at higher risk of developing the disease and having a severe form, but also present higher mortality rates [10,11,12]. Furthermore, large collaborative registries suggest that COVID-19 positive lung cancer patients are at highest risk of dismall prognosis [13, 14].

However, around 80% of COVID-19-positive patients in the general population have only mild symptoms of the disease, and an undefined number are asymptomatic transmitters [1]. It is of utmost importance to collect more data regarding the safety of systemic anti-cancer treatments in cancer patients with a non-severe form of COVID-19 [15, 16]. Indeed, in the presence of mild symptoms, COVID-19 infection can remain undetected due to the absence or unavailability of repeatable rapid screening methods. Access to SARS-CoV-2 RT-PCR testing was limited in Belgium during the initial pandemic due to logistics; its availability focused mainly on patients with severe COVID-19 that required hospitalization. The Belgian authorities authorized serological testing to detect post-infection antibodies in the population on May 20, 2020. As we did not screen asymptomatic patients or those with only mild symptoms during the pandemic, we suspected that some of our patients with non-severe SARS-CoV-2 infection have received systemic anti-cancer treatment. We therefore undertook a prospective study between June 12 and July 13, 2020 and offered serological testing to each cancer patient undergoing systemic treatment in our cancer day unit. Our main objective was to retrospectively report the complication rates of systemic treatment in cancer patients with non-severe COVID-19 infection, identified by SARS-CoV-2 RT-PCR or serology, in comparison to SARS-CoV-2-negative patients. We also aimed to identify the discriminant symptoms and clinical/radiological factors associated with SARS-CoV-2 positivity, and to estimate the seroprevalence of antibodies against SARS-CoV-2 in this population.


Study design, inclusion criteria, study objectives and endpoints

ONCOSARS-1 was a single center, academic observational study of a cohort prospectively collected at Institut Roi Albert II, Cliniques universitaires Saint-Luc (CUSL), a tertiary cancer center and the largest in Brussels, Belgium. The inclusion criteria were: (i) patients older than 18 years, (ii) with a diagnosis of active solid cancer, (iii) having received systemic anti-cancer therapy between February 15 and May 31, 2020, (iv) admitted to the oncology day unit between June 12 and July 13, 2020, (v) who agreed to have a SARS-CoV-2 serological test and (vi) who signed an informed consent. There were no exclusion criteria. Hematological cancer patients are treated in a separate outpatient unit and did not take part in this study.

In this selected group of patients, our main objective was to retrospectively investigate the safety of systemic anti-cancer treatment administered to SARS-CoV-2-positive patients in a day unit setting. By doing so, we also aimed to identify the discriminant symptoms and clinical or radiological factors associated with SARS-CoV-2 positivity, and to estimate the seroprevalence of SARS-CoV-2 in this population. The primary endpoint was the rate of adverse events in SARS-CoV-2-positive patients compared to SARS-CoV-2-negative patients according to the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0.

SARS-CoV-2-positive patients were defined as patients in whom SARS-CoV-2 RNA was detected by RT-PCR in a nasopharyngeal swab between February 15 and July 13, 2020, or as patients with a positive SARS-CoV-2 serological test between June 12 and July 13, 2020. The study was approved by our Ethics Committee (2020/18MAI/278) on June 8, 2020, and all patients signed an informed consent.

In parallel to this study, all cancer healthcare workers had the opportunity to have a SARS-CoV-2 serological test at the same timepoint following informed consent.

SARS-CoV-2 serological test and RT-PCR

Qualitative detection of SARS-CoV-2 total antibodies in human serum was performed on the Cobas e602 using Elecsys anti-SARS-CoV-2 electrochemiluminescent immunoassay (ECLIA) (Roche Diagnostics, Mannheim, Germany). This assay uses a recombinant nucleocapsid antigen for the detection of anti-SARS-CoV-2 antibodies. According to the manufacturer’s insert, a cutoff index of ≥1.0 indicates a positive result [17].

SARS-CoV-2 RNA detection in nasopharyngeal swabs relies on the genesig® Real-Time RT-PCR assay (Primerdesign Ltd., Chandler’s Ford, United Kingdom). This assay, performed on RNA extracts, allows the detection of viral RNA by targeting the RNA-dependent RNA polymerase (RdRp) gene. The amplification was performed on a LightCycle 480 instrument (Roche Diagnostics, Mannheim, Germany) according to the manufacturer’s recommendations. A test with a cycle threshold under 40 was considered positive.

Data extraction

Data were systematically collected for all patients admitted to our oncology unit. At the beginning of the pandemic, the pre-defined data template was adapted to highlight COVID-19 symptoms (Supplementary appendix 1). Clinical data regarding patient demographics, comorbidities, cancer type and stage, oncological treatment, adverse events (graded according to CTCAE v5.0), COVID-19 related symptoms (fever, cough, anosmia, dyspnea and rhinitis), thoracic imaging and SARS-CoV-2 testing (RT-PCR and serology) were collected and managed using REDCap (Research Electronic Data Capture) tools hosted at CUSL [18, 19]. Data were collected during the initial pandemic outbreak in Belgium (February 15 – May 31, 2020).

Statistical analysis

The distribution of clinical characteristics, thoracic imaging findings and outcomes between SARS-CoV-2-positive and -negative patients (as detected through RT-PCR or serology) was compared using the Fisher’s exact or Mann-Whitney test, as appropriate. Bonferroni correction was applied for multi-testing. The frequency of treatment-related adverse events was compared using Fisher’s exact test. Univariate and multivariate logistic regression modelling was used to identify risk factors associated with (i) adverse events significantly more frequent in SARS-CoV-2- positive patients and (ii) SARS-CoV-2 seroconversion. The threshold to include candidate variables in the multivariate model was set at 10%, and a backward stepwise selection was used to obtain the optimal model. In all analyses, p-values were 2-tailed, and P-values < 0.05 were considered statistically significant. Data analyses were performed using SAS software (version 9.4, SAS Institute Inc., NC, USA).


Patient characteristics and incidence of SARS-CoV-2 detection

Of the 415 patients admitted to our oncology day unit between June 12 and July 13, 2020, 379 (91%) signed the informed consent and 363 (87%) met our inclusion criteria (Fig. 1). Table 1 outlines the main patient characteristics. All eligible patients meeting the inclusion criteria (n = 363) had SARS-CoV-2 serology performed. Among these, 141 (38.8%) underwent RT-PCR during the COVID-19 pandemic: 22 (16%) had symptoms suggestive of a SARS-CoV-2 infection that triggered the test and 119 (84%) were tested as part of a systematic screening plan. This plan, introduced by CUSL, from April 1, 2020, mandated that all patients planned for a medical procedure or overnight stay must undergo systematic screening with SARS-CoV-2 RT-PCR. However, this systematic screening was not implemented in the outpatient oncology day unit, mainly due to logistical reasons.

Fig. 1
figure 1

Flowchart showing patient enrollment and exclusion

Table 1 Patients’ characteristics

According to RT-PCR and/or serological test, 22 (6%) of the 363 eligible patients had been exposed to SARS-CoV-2. One hundred forty-one patients were tested by RT-PCR, 14 (10%) were positive. For RT-PCR, the positivity rate varied largely between symptomatic and systematically screened patients: 9 out of 22 (41%) versus 5 out of 119 (4%), respectively (odds ratio (OR) 15.8, P < 0.001). Seventeen (5%) of the 363 patients had detectable antibodies against SARS-CoV-2. SARS-CoV-2 seroconversion was detected in 9 (64%) of the RT-PCR-positive patients (Table S1).

Three hundred and 49patients did not undergo any RT-PCR test or had a negative RT-PCR test (Table S2). Eight (2%) of these patients developed antibodies against SARS-CoV-2. Five of these eight had undergone an RT-PCR test, but none experienced COVID-19 symptoms.

SARS-CoV-2-positive patients diagnosed either by RT-PCR or serological test (n = 22) did not statistically differ from SARS-CoV-2-negative patients (n = 341) with regards to potential risk factors for severe COVID-19 disease (age, comorbidities, smoking, lung cancer, advanced disease, number of lines of systemic therapies for advanced disease, Eastern Cooperative Oncology Group (ECOG) performance status) (Table 1) [20]. However, the SARS-CoV-2-negative patients had received overall more immunotherapy, generating an imbalance between the treatment groups (P = 0.029). In terms of cancer types, head and neck cancers and skin cancers were only observed in the SARS-CoV-2 negative group. SARS-CoV-2-positive patients received more thoracic radiotherapy over the previous six months (P = 0.007). These same trends were also seen numerically in the COVID-19 subgroups detected through RT-PCR alone (Table S1) or serology alone (Table S2).

COVID-19 symptoms and thoracic imaging

Among the 363 patients, 150 (41%) developed symptoms suggestive of COVID-19 infection and 213 (59%) remained asymptomatic. Although present in only 5 (23%) SARS-CoV-2-positive patients, anosmia appeared to be the most discriminant symptom, as no anosmia was reported in the SARS-CoV-2-negative patients (P < 0.001). Dyspnea and rhinitis were not discriminant, being frequently reported in treated cancer patients. SARS-CoV-2-positive patients presented at least one of the more specific COVID-19 symptoms (fever or cough or anosmia) more frequently during the follow-up period (46% vs 13%, P < 0.001) (Table 1). Similar findings were observed in the subgroups of COVID-19 detected through RT-PCR alone (Table S1) or serology alone (Table S2).

Overall, 280 (77%) patients underwent a thoracic computed tomography (CT) scan or a 2′-deoxy-2′-[18F] fluoro-D-glucose positron emission tomography (18-FDG-PET) coupled with a thoracic CT scan during the follow-up period, representing 64 and 78% of the SARS-CoV-2-positive and -negative patients, respectively (P = 0.123) (Table 1). These images were pre-planned to evaluate treatment efficacy in 97% of patients. Radiologic signs potentially related to COVID-19 [21] were more frequent in the SARS-CoV-2-positive patients (37% versus 7%, P < 0.001). Analyses of the subgroups of patients diagnosed by RT-PCR alone or by serology alone revealed the same trend (Tables S1 and S2). Eight (89%) out of nine patients with a positive RT-PCR with subsequent seroconversion presented COVID-19 symptoms and/or suggestive CT scan findings. In contrast, only one (20%) out of five patients with a positive RT-PCR but a negative serological test presented symptoms and/or suggestive CT scan findings (P = 0.023).

Adverse events reported during systemic oncological treatments

SARS-CoV-2-positive patients identified either by RT-PCR or serology (n = 22) presented more hematological adverse events compared to SARS-CoV-2-negative patients (n = 341) (73% vs 35%, P < 0.001). Adverse events for neutropenia and lymphopenia were of all grades (Table 2). Only grade 1–2 thrombopenia was observed. There were no significant differences between the SARS-CoV-2-positive and -negative patients with regards to other observed adverse events. Bleeding, infections unrelated to COVID-19, and febrile neutropenia occurred at a low rate in the SARS-CoV-2 positive patients (Table 2). Both subgroups of COVID-19 detected only through RT-PCR (Table S3) or only through serology (Table S4) presented similar results. In both univariate and multivariate analyses, SARS-CoV-2 positivity, a lower performance status (ECOG 2–3), and treatment with chemotherapy were significantly associated with hematological toxicity. Advanced disease, higher age, the presence of a comorbidity, and symptoms of COVID-19, were not (Table 3). Table S5 depicts the landscape of treatment regimens the patients received and the number of grade 3–4 hematological adverse events, according to the SARS-CoV-2 status.

Table 2 Adverse events recorded during systemic oncological treatment
Table 3 Factors potentially associated with hematological toxicity

SARS-CoV-2-positive patients experienced more frequent treatment delays than SARS-CoV-2-negative patients: 55% vs 20%, respectively (P < 0.001). However, the length of delay did not differ between the two groups: median 14 vs 11 days, respectively (P = 0.504). The relationship between treatment delays and hematological adverse events was significant (P < 0.001, Fisher exact test).

Two SARS-CoV-2-positive patients, detected by RT-PCR and later confirmed by serology, prematurely ended their ongoing systemic treatment during the study period; one developed complicated sigmoid diverticulitis, while the second developed grade 2 peripheral neuropathy. Three SARS-CoV-2-negative patients also stopped treatment prematurely; two due to adverse events and one to disease progression. No patients stopped treatment due to the pandemic.

Factors associated with seroconversion

To further assess the factors associated with positive SARS-CoV-2 serology, univariate and multivariate analyses were performed (Table 4). SARS-CoV-2 positivity by RT-PCR was the strongest factor associated with seropositivity. The main COVID-related symptoms (fever, cough or anosmia), or a thoracic CT scan with lung infiltrates suggestive of COVID-19 infection, were also significantly associated with seroconversion in both the univariate and multivariate analyses. A higher age, the presence of a comorbidity, lung cancer, recent morbid surgery, or advanced disease were not associated with seroconversion. Recent thoracic radiotherapy was significantly associated with positive serology in the univariate analysis but not in the multivariate analysis.

Table 4 Logistic regression of factors potentially associated with positive SARS-CoV-2 serology

COVID-19 outcomes

Five of the 22 (23%) SARS-CoV-2-positive patients were hospitalized due to COVID-19 infection. Of these, three required transient nasal oxygen therapy. All developed antibodies against SARS-CoV-2. Four additional patients were hospitalized with presumed COVID-19, but their status was validated neither by RT-PCR nor by thoracic imaging. These four patients eventually had negative serology.

COVID-19 in Belgium, at CUSL, and in the health care workers of the CUSL ambulatory cancer care unit

Table 5 summarizes the COVID-19 pandemic epidemiology in Belgium and the main actions our cancer center implemented according to national and institutional recommendations. Belgian official COVID-19 data are continuously updated on Between February 15 and July 13, 2020, only two (7%) out of the 28 physicians who attended the outpatient cancer center daily developed a symptomatic COVID-19 infection documented by SARS-CoV-2 RT-PCR. None of the other physicians nor the unit’s 19 oncological nurses developed a symptomatic infection. All healthcare workers were tested for SARS-CoV-2 antibodies during the same period as the ONCOSARS-1 study. Only the two physicians who were positive for SARS-CoV-2 by RT-PCR developed antibodies against SARS-CoV-2.

Table 5 General information regarding COVID-19 epidemiology and timing of the main measures in Belgium and at Cliniques universitaires Saint-Luc (CUSL)


The rapid spread and non-negligible risk of a fatal outcome due to COVID-19 has triggered scientific societies and healthcare systems to define strategies to mitigate the risk of infection in vulnerable patients [3, 4]. Here we present the results of a cohort study of ambulatory cancer patients treated with systemic therapy during the first peak of the pandemic period in Belgium.

In our study, only 6% of patients (a finding similar to what is seen at the time of writing this article in the general Belgian population, see Table 5), and 7% of healthcare workers had laboratory proven contact with the virus (positive RT-PCR or detectable anti-SARS-CoV-2 antibodies). We hypothesize that the rapid implementation of preventative measures (systematic screening of patients with fever or acute airway tract symptoms before entering the oncology day unit, prohibiting visitors unless medically advised, the strong recommendation to wear a face mask, and social distancing) was a key factor, at least in part, in our low rate of SARS-CoV-2 infection [22].

Our SARS-CoV-2-positive patients presented more frequently with fever, cough or anosmia. Although clearly associated with COVID-19 in the general population, [20] dyspnea, a frequent symptom of cancer patients, as well as fatigue and diarrhea, frequently reported as treatment-related adverse events, appeared less discriminant in our cancer patients (Tables 1 and 3). This illustrates just one aspect of the diagnostic challenge during this pandemic. We observed that five out of eight (63%) patients who were not diagnosed with COVID-19 during the pandemic, but for which a seroconversion was detected afterwards, had presented at least one COVID-19 related symptom. This highlights the need to implement large COVID-19 screening programs in cancer patients to avoid spread of the virus, even among patients with no or very mild COVID-19 symptoms. We found that SARS-CoV-2-positive patients had more characteristic lung infiltrates on CT-scan. This finding was also observed in SARS-CoV-2-positive patients who were not detected during the three first months of the pandemic but who were subsequently diagnosed through serological testing. This suggests that thoracic imaging is also a useful screening tool.

Delivering optimal systemic anti-cancer treatment while protecting our patients and medical staff are key objectives during this pandemic. Except the implementation of specific protective measures depicted in Table 5, we did not modify our standard day unit treatment protocols. The safety data we report here are therefore reassuring. We only found a higher rate of hematological adverse events in the SARS-CoV-2-positive patients including all grades of neutropenia and lymphopenia, with the latter being the most commonly found biological abnormality in this disease [20]. These two adverse events could thus reflect a COVID-19 symptom without additional treatment toxicity. Hematotoxicity led to a higher rate of treatment delays. Importantly, we did not encounter any increase in the other assessed adverse events in SARS-CoV-2-positive patients, whereas bleeding, infections unrelated to COVID-19, and febrile neutropenia rates were low. A multivariate analysis confirmed that hematological toxicity was significantly associated with the presence of SARS-CoV-2 antibodies after adjusting for patient’s performance status and type of systemic treatment. A poorer performance status and the administration of chemotherapy were also significantly associated with hematological toxicity. Recently published data is consistent with our findings: in a cohort study of 309 COVID-19-positive cancer patients, the administration of chemotherapy was not associated with a severe form of the disease [23]. Likewise, in a cohort study of 1016 cancer patients, SARS-CoV-2 infection rates remained as low as in the general population after the implementation of institutional safety measures [24]. Our patients received a vast landscape of chemotherapy regimens, which prevents us from estimating whether certain specific treatment schedules are more likely to be associated with toxicity.

Previous work hypothesized that cancer patients are less likely to develop or maintain antibodies against SARS-CoV-2 [25]. This study adds data to this assumption, as only nine out of 14 (64%) patients with a positive SARS-CoV-2 RT-PCR test had detectable antibody levels at study inclusion. In this population, the presence of symptoms or lung infiltrates on CT-scan suggestive of COVID-19 was significantly associated with the development of antibodies. However, we could not find definitive risk factors for the development of antibodies against SARS-CoV-2. Administration of radiotherapy to the thoracic area within the previous 6 m was significantly associated with seroconversion in the univariate but not multivariate analysis, warranting exploration in larger cohorts.

Our study has several limitations. First, we prospectively recruited only patients who were still being actively treated with anti-cancer therapy after the first peak of the pandemic. Therefore, we cannot exclude that we missed some SARS-CoV-2-negative and non-severe SARS-CoV-2-positive patients treated during the pandemic who had already stopped treatment before the study began. Second, we cannot guarantee that some medical decisions, such as complementary tests and/or treatment options, were not taken with the pandemic in mind. Third, at the beginning of the pandemic, the decision whether to perform SARS-CoV-2 RT-PCR testing was taken in the context of testing kit shortages. Likewise, it was logistically not feasible to compensate for the lack of tests by offering thoracic CT scans. Fourth, this study focused on solid cancer patients. While haematological cancer patients do not appear at increased risk of SARS-CoV-2 infection, they are at higher risk of developing severe COVID-19 [26]. Our results should thus not be extrapolated to them. Finally, the rate of false negative results from the nasopharyngeal RT-PCR test is reported to be in the order of 30–40% [27]. This reduces the accuracy of any data ever reported for COVID-19. Likewise, several tests exist to detect antibodies against SARS-CoV-2, with highly variable diagnostic accuracies [28]. However, the electrochemiluminescent immunoassay we used has a high sensitivity (91%) and specificity (100%) at the cut-off pre-specified by the manufacturer [29].


This cohort study of patients with solid cancers actively treated during the COVID-19 pandemic demonstrates that when strong preventive measures are taken to protect patients and healthcare workers, systemic anti-cancer therapy can be safely administered to SARS-CoV-2-positive patients not presenting with a severe form of the infection. Attention should especially focus on hematological adverse events. Typical COVID-19 symptoms (fever, cough or anosmia) should trigger SARS-CoV-2 RT-PCR testing to confirm or rule out SARS-CoV-2 infection.

Availability of data and materials

All data generated or analyzed during this study are included in this published article and its supplementary information files.



2′-deoxy-2′-[18F] fluoro-D-glucose positron emission tomography


Computed tomography


Common Terminology Criteria for Adverse Events


Cliniques universitaires Saint-Luc


Electrochemiluminescent immunoassay


Eastern Cooperative Oncology Group


Reverse transcription polymerase chain reaction


Severe acute respiratory syndrome coronavirus-2


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The authors wish to thank all fellows in medical oncology and the nursing staff of the medical oncology department who took care of the patients during the pandemic, as well as Ms. Marie-Laure Castella for administrative work and Ms. Aileen Eiszele of A&L Medical Communications for writing assistance and manuscript review. Aileen’s involvement was funded through academic funding.


This work was supported by institutional academic funding. The funding bodies played no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.

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CVM, NH, AVDE, JCY, AS and JPM wrote the study protocol. CVM, NH, AVDE, SB, FD, CD, FAN, JFB, IB, PC, FC, ADC, FPD, BF, RG, MG, FM, TP, ES, IS, MVDE, NW, JCY and JPM contributed to the care of patients and collection of data. AS analyzed the SARS-CoV-2 diagnostic tests. CVM and AVM performed the statistical analyses. CVM, NH, AVDE and JPM wrote the manuscript. All authors have read, substantively revised and approved the submitted manuscript.

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Correspondence to J. P. Machiels.

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The study was approved by the Ethics Committee of Cliniques universitaires Saint-Luc (2020/18MAI/278) on June 8, 2020, and all patients signed an informed consent.

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The authors declare that they have no competing interests.

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Supplementary Information

Additional file 1: Table S1

. Characteristics of patients who had SARS-CoV-2 RT-PCR. Table S2. Characteristics of patients diagnosed by SARS-CoV-2 serology (SARS-CoV-2 RT-PCR not performed or negative). Table S3. Adverse events with systemic therapy in the population with RT-PCR results. Table S4. Adverse events with systemic therapy in the population without or with negative RT-PCR results. Table S5. Landscape of treatment regimens the patients received and the number of grade 3–4 hematological adverse events, according to the SARS-CoV-2 status. Supplementary appendix 1: Framework used to notify adverse events at each cycle of anti-cancer treatment.

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van Marcke, C., Honoré, N., van der Elst, A. et al. Safety of systemic anti-cancer treatment in oncology patients with non-severe COVID-19: a cohort study. BMC Cancer 21, 578 (2021).

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