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  1. Liver cancer is the sixth most commonly diagnosed cancer and the fourth most common cause of cancer death. The purpose of this work is to find new diagnostic biomarkers or prognostic biomarkers and explore the...

    Authors: Shiyong Gao, Jian Gang, Miao Yu, Guosong Xin and Huixin Tan
    Citation: BMC Cancer 2021 21:791
    Content type: Research article Published on:

  2. Currently it is unclear how in situ breast cancer progresses to invasive disease; therefore, a better understanding of the events that occur during the transition to invasive carcinoma is warranted. Here we ha...

    Authors: Julia Samson, Magdalina Derlipanska, Oza Zaheed and Kellie Dean
    Citation: BMC Cancer 2021 21:790
    Content type: Research article Published on:

  3. There are no epidemiological studies describing rare cancers in Western Australia (WA). We aimed to fill this gap by estimating the incidence and five-year survival of rare, less common and common cancers in W...

    Authors: Gemma A. Bilkey, Richard W. Trevithick, Emily P. Coles, Jennifer Girschik and Kristen J. Nowak
    Citation: BMC Cancer 2021 21:779
    Content type: Research Published on:

  4. Irreversible electroporation (IRE) is a local ablation technique utilizing high voltage, low energy direct current to create nanopores in cell membrane which disrupt homeostasis and leads to cell death. Previo...

    Authors: Govindarajan Narayanan, Malcolm M. Bilimoria, Peter J. Hosein, Zhaohui Su, Kathleen M. Mortimer and Robert C. G. Martin II
    Citation: BMC Cancer 2021 21:785
    Content type: Study protocol Published on:

  5. Minichromosome maintenance complex component 6 (MCM6), as an important replication permission factor, is involved in the pathogenesis of various tumors. Here we studied the expression of MCM6 in neuroblastoma ...

    Authors: Yaoyao Gu, Xiaoxiao Hu, Xiaowei Liu, Cheng Cheng, Kai Chen, Yeming Wu and Zhixiang Wu
    Citation: BMC Cancer 2021 21:784
    Content type: Research article Published on:

  6. Lung cancer is one of the dominant causes of cancer-related deaths worldwide. Ferroptosis, an iron-dependent form of programmed cell death, plays a key role in cancer immunotherapy. However, the role of immuni...

    Authors: Taisheng Liu, Honglian Luo, Jinye Zhang, Xiaoshan Hu and Jian Zhang
    Citation: BMC Cancer 2021 21:783
    Content type: Research article Published on:

  7. Accumulated studies indicate that aberrant expression of long noncoding RNAs (lncRNAs) is associated with tumorigenesis and progression of colon cancer. In the present study, long intergenic non-protein coding...

    Authors: Dazhi Fu, Yongjun Ren, Chunxiao Wang, Lei Yu and Rui Yu
    Citation: BMC Cancer 2021 21:782
    Content type: Research article Published on:

  9. Hepatic metastases occur frequently in the context of many tumor entities. Patients with colorectal carcinoma have already developed liver metastases in 20% at the time of diagnosis, and 25–50% develop metasta...

    Authors: Theresa Voglhuber, Kerstin A. Eitz, Markus Oechsner, Marco M. E. Vogel and Stephanie E. Combs
    Citation: BMC Cancer 2021 21:780
    Content type: Research Published on:

  11. The overwhelming majority of dose-escalation clinical trials use methods that seek a maximum tolerable dose, including rule-based methods like the 3+3, and model-based methods like CRM and EWOC. These methods ...

    Authors: Kristian Brock, Victoria Homer, Gurjinder Soul, Claire Potter, Cody Chiuzan and Shing Lee
    Citation: BMC Cancer 2021 21:777
    Content type: Research article Published on:

  12. The incidence of anal squamous cell carcinoma has been increasing, particularly in people living with HIV (PLWH). There is concern that radiosensitizing drugs, such as protease inhibitors, commonly used in the...

    Authors: Alison K. Yoder, David S. Lakomy, Yongquan Dong, Suchismita Raychaudhury, Kathryn Royse, Christine Hartman, Peter Richardson, Donna L. White, Jennifer R. Kramer, Lilie L. Lin and Elizabeth Chiao
    Citation: BMC Cancer 2021 21:776
    Content type: Research article Published on:

  13. Few biomarkers can predict the efficiency of PD-1 blockade in patients with hepatocellular carcinoma (HCC). This study aimed to investigate the prognostic role of AFP and PIVKA-II in HCC patients receiving ant...

    Authors: Xuqi Sun, Jie Mei, Wenping Lin, Ziliang Yang, Wei Peng, Jinbin Chen, Yaojun Zhang, Li Xu and Minshan Chen
    Citation: BMC Cancer 2021 21:775
    Content type: Research Published on:

  14. For stage I to II high-risk endometrioid adenocarcinoma patients, the optimal adjuvant radiotherapy modality remains controversial. The present study sought to optimize the treatment of pelvic external beam ra...

    Authors: Wenhui Wang, Lijuan Zou, Tiejun Wang, Zi Liu, Jianli He, Xiaoge Sun, Wei Zhong, Fengju Zhao, Xiaomei Li, Sha Li, Hong Zhu, Zhanshu Ma, Shuai Sun, Meng Jin, Fuquan Zhang, Xiaorong Hou…
    Citation: BMC Cancer 2021 21:774
    Content type: Research Published on:

  15. Synovial sarcoma is an aggressive but chemosensitive soft-tissue tumor. We retrospectively analyzed the efficacy of perioperative chemotherapy for synovial sarcoma with data from the nationwide database, Bone ...

    Authors: Gang Xu, Hisaki Aiba, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Takashi Higuchi, Kensaku Abe, Yuta Taniguchi, Yoshihiro Araki, Shiro Saito, Kenichi Yoshimura, Hideki Murakami, Hiroyuki Tsuchiya and Akira Kawai
    Citation: BMC Cancer 2021 21:773
    Content type: Research article Published on:

  16. Epidermal growth factor-like domain 7 (Egfl7), a recently identified secreted protein, was significantly increased in patients with HCC by our previous studies. However, its efficacy in the diagnosis of early ...

    Authors: Meng-Yuan Yang, Fan Wu, Feng Fang, Hao Yang, Jing-Fan Zhang, Guo-Dong Chen and Lian-Yue Yang
    Citation: BMC Cancer 2021 21:772
    Content type: Research Published on:

  17. Due to negative results in clinical trials of postoperative chemoradiation for gastric cancer, at present, there is a tendency to move chemoradiation therapy forward in gastric and gastroesophageal junction (G...

    Authors: Yu-Jie Zhou, Xiao-Fan Lu, Jia-Lin Meng, Xin-Yuan Wang, Qing-Wei Zhang, Jin-Nan Chen, Qi-Wen Wang, Fang-Rong Yan and Xiao-Bo Li
    Citation: BMC Cancer 2021 21:771
    Content type: Research article Published on:

  18. Various studies investigating the clinical significance of FBXW7 mutation and/or expression have yielded inconclusive results in colorectal cancer (CRC) patients. Therefore, the present meta-analysis summarize...

    Authors: Wei Shang, Chuanwang Yan, Ran Liu, Lili Chen, Dongdong Cheng, Liang Hao, Wenguang Yuan, Jingbo Chen and Hui Yang
    Citation: BMC Cancer 2021 21:770
    Content type: Research article Published on:

  20. The heterogeneous subtypes and stages of epithelial ovarian cancer (EOC) differ in their biological features, invasiveness, and response to chemotherapy, but the transcriptional regulators causing their differ...

    Authors: Yichao Li, Sushil K. Jaiswal, Rupleen Kaur, Dana Alsaadi, Xiaoyu Liang, Frank Drews, Julie A. DeLoia, Thomas Krivak, Hanna M. Petrykowska, Valer Gotea, Lonnie Welch and Laura Elnitski
    Citation: BMC Cancer 2021 21:768
    Content type: Research Published on:

  21. The change of immune cell infiltration essentially influences the process of colorectal cancer development. The infiltration of immune cells can be regulated by a variety of genes. Thus, modeling the immune mi...

    Authors: Shaokun Wang, Li Pang, Zuolong Liu and Xiangwei Meng
    Citation: BMC Cancer 2021 21:767
    Content type: Research Published on:

  22. The surgical management and outcomes of renal cell carcinoma (RCC) with venous tumor thrombus (VTT) have been reported in limited sample size, and there remain discrepancies over the factors that influence onc...

    Authors: Zhigang Chen, Feilong Yang, Liyuan Ge, Min Qiu, Zhuo Liu, Cheng Liu, Xiaojun Tian, Shudong Zhang and Lulin Ma
    Citation: BMC Cancer 2021 21:766
    Content type: Research article Published on:

  23. The formation of blood vessels within solid tumors directly contributes to cancer growth and metastasis. Until recently, tumor vasculature was thought to occur exclusively via endothelial cell (EC) lined struc...

    Authors: Carmela Martini, Mark DeNichilo, Danielle P. King, Michaelia P. Cockshell, Brenton Ebert, Brian Dale, Lisa M. Ebert, Anthony Woods and Claudine S. Bonder
    Citation: BMC Cancer 2021 21:765
    Content type: Research article Published on:

  24. Cement leakage into venous blood posed significant challenge to surgeons. The aim of the study was to create a Peking University First Hospital Score (PUFHS) which could evaluate the probability of vascular ce...

    Authors: Xuedong Shi, Yunpeng Cui, Yuanxing Pan, Bing Wang and Mingxing Lei
    Citation: BMC Cancer 2021 21:764
    Content type: Research Published on:

  25. Algorithms that use administrative health and electronic medical record (EMR) data to determine cancer recurrence have the potential to replace chart reviews. This study evaluated algorithms to determine breas...

    Authors: Pascal Lambert, Marshall Pitz, Harminder Singh and Kathleen Decker
    Citation: BMC Cancer 2021 21:763
    Content type: Research article Published on:

  26. Malignant pleural mesothelioma (MPM) is a rare and aggressive malignancy that most commonly affects the pleural layers. MPM has a strong association with asbestos, mainly caused by exposure to its biopersisten...

    Authors: Laura Saracino, Chandra Bortolotto, Stefano Tomaselli, Elia Fraolini, Matteo Bosio, Giulia Accordino, Francesco Agustoni, David M. Abbott, Emma Pozzi, Dimitrios Eleftheriou, Patrizia Morbini, Pietro Rinaldi, Cristiano Primiceri, Andrea Lancia, Patrizia Comoli, Andrea R. Filippi…
    Citation: BMC Cancer 2021 21:762
    Content type: Research article Published on:

  27. Immunotherapy is revolutionising the treatment of patients diagnosed with melanoma and other cancers. The first immune checkpoint inhibitor, ipilimumab (targeting cytotoxic T-lymphocyte-associated antigen 4 (C...

    Authors: Oliver Coen, Pippa Corrie, Helen Marshall, Ruth Plummer, Christian Ottensmeier, Jane Hook, Sue Bell, Gurdeep S. Sagoo, David Meads, Janine Bestall, Galina Velikova, Ferdia A. Gallagher, Alexandra Smith, Helen Howard, Ellen Mason, Eszter Katona…
    Citation: BMC Cancer 2021 21:761
    Content type: Study protocol Published on:

  28. Breast cancer is the leading cause of cancer-related deaths in females worldwide. Formin-like protein 2 (FMNL2) is a member of formin family that governs cytokinesis, cell polarity, morphogenesis and cell divi...

    Authors: Xinyan Jiao, Bo Wang, Chen Feng, Shaoran Song, Bixia Tian, Can Zhou, Xiaoqian Gao, Wei Sun and Peijun Liu
    Citation: BMC Cancer 2021 21:760
    Content type: Research article Published on:

  29. The Swedish healthcare is decentralised to 21 regions. Detailed information on all delivered care in the southernmost region, Skåne, is prospectively collected in the Skåne Healthcare Register (SHR). The data ...

    Authors: Qing Shen, Maria E. C. Schelin, Fang Fang and Anna Jöud
    Citation: BMC Cancer 2021 21:759
    Content type: Research article Published on:

  30. Eribulin mesylate (ERI; Halaven®) is a microtubule inhibitor approved in the United States for metastatic breast cancer patients with at least two prior chemotherapy regimens for metastatic breast cancer, and ...

    Authors: Qi Zhao, Rachel Hughes, Binod Neupane, Kristin Mickle, Yun Su, Isabelle Chabot, Marissa Betts and Ananth Kadambi
    Citation: BMC Cancer 2021 21:758
    Content type: Research article Published on:

  31. International differences in survival among colorectal cancer (CRC) patients may partly be explained by differences in emergency presentations (EP), waiting times and access to treatment.

    Authors: Yngvar Nilssen, Morten Tandberg Eriksen, Marianne G. Guren and Bjørn Møller
    Citation: BMC Cancer 2021 21:757
    Content type: Research Published on:

  32. Chemotherapy regimens that include the utilization of gemcitabine are the standard of care in pancreatic cancer patients. However, most patients with advanced pancreatic cancer die within the first 2 years aft...

    Authors: Patrick Innamarato, Jennifer Morse, Amy Mackay, Sarah Asby, Matthew Beatty, Jamie Blauvelt, Scott Kidd, John E. Mullinax, Amod A. Sarnaik and Shari Pilon-Thomas
    Citation: BMC Cancer 2021 21:756
    Content type: Research Published on:

  33. Almost all Koreans are covered by mandatory national health insurance and are required to undergo health screening at least once every 2 years. We aimed to develop a machine learning model to predict the risk ...

    Authors: Chansik An, Jong Won Choi, Hyung Soon Lee, Hyunsun Lim, Seok Jong Ryu, Jung Hyun Chang and Hyun Cheol Oh
    Citation: BMC Cancer 2021 21:755
    Content type: Research Published on:

  34. Corticosteroid therapy (CST) prior to biopsy may hinder histopathological diagnosis in primary central nervous system lymphoma (PCNSL). Therefore, preoperative CST in patients with suspected PCNSL should be av...

    Authors: Florian Scheichel, Franz Marhold, Daniel Pinggera, Barbara Kiesel, Tobias Rossmann, Branko Popadic, Adelheid Woehrer, Michael Weber, Melitta Kitzwoegerer, Klaus Geissler, Astrid Dopita, Stefan Oberndorfer, Wolfgang Pfisterer, Christian F. Freyschlag, Georg Widhalm, Karl Ungersboeck…
    Citation: BMC Cancer 2021 21:754
    Content type: Research article Published on:

  35. Terminal differentiation-induced ncRNA (TINCR) plays an essential role in epidermal differentiation and is involved in the development of various cancers.

    Authors: Guoqing He, Rui Pang, Jihua Han, Jinliang Jia, Zhaoming Ding, Wen Bi, Jiawei Yu, Lili Chen, Jiewu Zhang and Yanan Sun
    Citation: BMC Cancer 2021 21:753
    Content type: Research article Published on:

  36. As a marker of differentiation, Killer cell lectin like receptor G1 (KLRG1) plays an inhibitory role in human NK cells and T cells. However, its clinical role remains inexplicit. This work intended to investig...

    Authors: Xiaodong Yang, Yuexin Zheng, Zhihai Han and Xiliang Zhang
    Citation: BMC Cancer 2021 21:752
    Content type: Research article Published on:

  37. Radiofrequency ablation (RFA) is an effective treatment option for hepatocellular carcinoma (HCC). This study aimed to analyze the prognostic factors of HCC patients treated with RFA and to develop nomograms f...

    Authors: Zhenhua Lu, Zhen Sun, Chengyu Liu, Xiaolei Shi, Rui Li, Weiwei Shao, Yangyang Zheng, Yao Li and Jinghai Song
    Citation: BMC Cancer 2021 21:751
    Content type: Research article Published on:

  38. Tumor microenvironment (TME) critically contributed to the malignant progression of transformed cells and the chemical responses to chemotherapy reagents. Osteopontin (OPN) is a secretory onco-protein with sev...

    Authors: Jing Huang, Mu Hu, Huan Niu, Jing Wang, Yang Si, Shan Cheng and Wei Ding
    Citation: BMC Cancer 2021 21:750
    Content type: Research Published on:

  39. Advanced stage marginal zone lymphoma (MZL) is an incurable indolent B-cell lymphoma, for which a wide variety of treatments ranging from single agent rituximab to more dose intense immunochemotherapy exists. ...

    Authors: Alexander Grunenberg, Lisa M. Kaiser, Stephanie Woelfle, Birgit Schmelzle, Andreas Viardot, Peter Möller, Thomas F. E. Barth, Rainer Muche, Jens Dreyhaupt, Markus Raderer, Barbara Kiesewetter and Christian Buske
    Citation: BMC Cancer 2021 21:749
    Content type: Study protocol Published on:

  41. The molecular pathogenesis of endometrial cancer is not completely understood. CypB upregulated in many cancers, however, its role in endometrial carcinoma has not been studied. Here, we determine the effect o...

    Authors: Jing Liu, Ying Zuo, Gui-Mei Qu, Xiao Song, Zhong-Hui Liu, Ting-Guo Zhang, Zhu-Hua Zheng and Hong-Kun Wang
    Citation: BMC Cancer 2021 21:747
    Content type: Research article Published on:

  42. Considerable evidence has indicated an association between the immune microenvironment and clinical outcome in ccRCC. The purpose of this study is to extensively figure out the influence of immune-related gene...

    Authors: Guangyao Li, Xiyi Wei, Shifeng Su, Shangqian Wang, Wei Wang, Yichun Wang, Xianghu Meng, Jiadong Xia, Ninghong Song and Chao Qin
    Citation: BMC Cancer 2021 21:746
    Content type: Research article Published on:

  44. Increased bone turnover is frequently observed in advanced cancer and predominantly related to bone metastases or therapy. Cachexia represents an important cause of morbidity and mortality in cancer patients. ...

    Authors: Hannes Zwickl, Elisabeth Zwickl-Traxler, Alexander Haushofer, Josef Seier, Klaus Podar, Michael Weber, Klaus Hackner, Nico Jacobi, Martin Pecherstorfer and Sonia Vallet
    Citation: BMC Cancer 2021 21:744
    Content type: Research Published on:

  45. Availability of potent anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKI) has pushed the median survival of ALK+ non-smallcell lung cancer (NSCLC) patients to over five years. In particular, second...

    Authors: Petros Christopoulos, Farastuk Bozorgmehr, Lena Brückner, Inn Chung, Johannes Krisam, Marc A. Schneider, Albrecht Stenzinger, Regina Eickhoff, Daniel W. Mueller and Michael Thomas
    Citation: BMC Cancer 2021 21:743
    Content type: Study protocol Published on:

  46. Carnitine is related to malaise, and cisplatin is associated with decreased carnitine. The purpose of this study was to elucidate the effects of one course of induction chemotherapy (IC) for head and neck canc...

    Authors: Tatsuya Ito, Kiyoaki Tsukahara, Hiroki Sato, Akira Shimizu and Isaku Okamoto
    Citation: BMC Cancer 2021 21:742
    Content type: Research Published on:

  47. From patient-reported surveys and individual interviews by health care providers, we attempted to identify the significant factors related to the improvement of distress and fatigue for cancer survivors by tex...

    Authors: Kyungmi Yang, Jina Kim, Mison Chun, Mi Sun Ahn, Eunae Chon, Jinju Park and Mijin Jung
    Citation: BMC Cancer 2021 21:741
    Content type: Research article Published on:

  48. NUT carcinoma (NC), previously known as NUT midline carcinoma, is a rare and very aggressive cancer that occurs in both children and adults. NC is largely chemoresistant, with an overall survival of less than ...

    Authors: Tina Carter, Maxine Crook, Ashleigh Murch, Alex H. Beesley, Nick de Klerk, Adrian Charles and Ursula R. Kees
    Citation: BMC Cancer 2021 21:740
    Content type: Research article Published on:

  49. The health burden of breast cancer is rising in China. The effect of informed diagnosis on long-term survival is not fully understood. This retrospective cohort study aims to explore the association between ea...

    Authors: Chen He, Wen Xi Zhu, Yunxiang Tang, Yonghai Bai, Zheng Luo, Jinfang Xu, Hao Wang, Shuyu Xu, Jingzhou Xu, Lei Xiao, Ruike Zhang, Yajing Wang, Jing Du, Yujia Huang, Xiaopan Li and Tong Su
    Citation: BMC Cancer 2021 21:739
    Content type: Research article Published on:

  50. To investigate the efficacy and safety of interval debulking surgery (IDS) combined with dense hyperthermic intraperitoneal chemotherapy (HIPEC) with cisplatin in Chinese patients with FIGO stage III serous ep...

    Authors: Xiaoli He, Li Wei, Rui Li, Shuang Jing, Linlin Jia, Danwei Ji, Yali Li, Yue Wang and Yongxia Zhu
    Citation: BMC Cancer 2021 21:738
    Content type: Research article Published on:

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