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3909 result(s) for 'lung cancer prognosis stage 4' within BMC Cancer

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  1. Understanding of immunobiology of bone marrow metastases (designated BM-NPC) versus primary tumors (P-NPC) of the nasopharynx is far from complete. The aim of this study was to determine if there would be differe...

    Authors: Andy Shau-Bin Chou, Hsin-Yi Wang, Hung-Chang Chen, Ming-Hsiu Tsai, Cheng-Keng Chuang and Shuen-Kuei Liao
    Citation: BMC Cancer 2009 9:169
    Content type: Research article Published on:

  2. One-half of hormone receptor-positive (HR +) breast cancer (BC) patients have low expression of HER2 (HER2-low) and may benefit from trastuzumab deruxtecan (TDXd). This study aimed to identify parameters assoc...

    Authors: Didi Feldman, Liat Anabel Sinberger, Mali Salmon-Divon, Judith Ben-Dror, Shlomit Strulov Shachar and Amir Sonnenblick
    Citation: BMC Cancer 2023 23:1031
    Content type: Research Published on:

  3. Human neuroblastoma (NB) cell lines may present with either one of the so-called S-and N-subtypes. We have previously reported a strong correlation between protein expression levels of vimentin, an S-subtype m...

    Authors: Xénia Mergui, Marie-Line Puiffe, Dominique Valteau-Couanet, Marc Lipinski, Jean Bénard and Mounira Amor-Guéret
    Citation: BMC Cancer 2010 10:473
    Content type: Research article Published on:

  4. Next Generation Sequencing (NGS) is expected to lift molecular diagnostics in clinical oncology to the next level. It enables simultaneous identification of mutations in a patient tumor, after which targeted t...

    Authors: S.E.P. Joosten, V.P. Retèl, V.M.H. Coupé, M.M. van den Heuvel and W.H. van Harten
    Citation: BMC Cancer 2016 16:66
    Content type: Research article Published on:

  5. Hyperglycemia or hyperinsulinemia contributes to poorer endometrial cancer survival. It was shown that P-LAP/IRAP translocates to the plasma membrane in response to insulin stimulation. Recently, we demonstrat...

    Authors: Kiyosumi Shibata, Hiroaki Kajiyama, Kazuhiko Ino, Akihiro Nawa, Seiji Nomura, Shigehiko Mizutani and Fumitaka Kikkawa
    Citation: BMC Cancer 2007 7:15
    Content type: Research article Published on:

  6. Patients with advanced gallbladder and biliary tract carcinoma face a dismal prognosis, as no effective palliative chemotherapy exists. The antitumor effect of gemcitabine is schedule-dependent rather than dos...

    Authors: Stefan von Delius, Christian Lersch, Ewert Schulte-Frohlinde, Martina Mayr, Roland M Schmid and Florian Eckel
    Citation: BMC Cancer 2005 5:61
    Content type: Research article Published on:

  7. Hepatitis B virus (HBV) is the major risk factor for hepatocellular carcinoma (HCC). The molecular mechanisms underlying HBV-associated HCC pathogenesis is still unclear. Genetic alterations in cancer-related ...

    Authors: Fung-Yu Huang, Danny Ka-Ho Wong, Vivien Wai-Man Tsui, Wai-Kay Seto, Lung-Yi Mak, Tan-To Cheung, Keane K.-Y. Lai and Man-Fung Yuen
    Citation: BMC Cancer 2019 19:789
    Content type: Research article Published on:

  8. Although numerous chemotherapeutic agents have been tested, the role of systemic chemotherapy for hepatocellular carcinoma (HCC) has not been clarified. New therapeutic strategies are thus needed to improve ou...

    Authors: Se Hoon Park, Yuna Lee, Sang Hoon Han, So Young Kwon, Oh Sang Kwon, Sun Suk Kim, Ju Hyun Kim, Yeon Ho Park, Jeong Nam Lee, Soo-Mee Bang, Eun Kyung Cho, Dong Bok Shin and Jae Hoon Lee
    Citation: BMC Cancer 2006 6:3
    Content type: Research article Published on:

  10. Gastric carcinoma is one of the most frequent cancers worldwide. Patients with gastric cancer at an advanced disease stage have a poor prognosis, due to the limited efficacy of available therapies. Therefore, ...

    Authors: Jessica Nöckel, Natasja K van den Engel, Hauke Winter, Rudolf A Hatz, Wolfgang Zimmermann and Robert Kammerer
    Citation: BMC Cancer 2006 6:57
    Content type: Research article Published on:

  11. Neuroendocrine tumours (NETs) are rare malignancies characterised by its capacity to synthesise and secrete monoamines, due to its neuroendocrine origin. Its varied locations and symptoms have traditionally be...

    Authors: Josep Darbà and Alicia Marsà
    Citation: BMC Cancer 2019 19:1226
    Content type: Research article Published on:

  12. Detection of programmed cell death ligand-1 (PD-L1) by immunohistochemistry (IHC) has been commonly used to predict the efficacy of treatment with PD-1/PD-L1 inhibitors. However, there is limited literature re...

    Authors: Yinying Zou, Liming Xu, Qiusu Tang, Qihan You, Xiaoling Wang, Wei Ding, Jing Zhao and Guoping Ren
    Citation: BMC Cancer 2020 20:344
    Content type: Research article Published on:

  13. Mucinous ovarian tumors represent a distinct histotype of epithelial ovarian cancer. The rarest (2-4 % of ovarian carcinomas) of the five major histotypes, their genomic landscape remains poorly described. We ...

    Authors: Robertson Mackenzie, Stefan Kommoss, Boris J. Winterhoff, Benjamin R. Kipp, Joaquin J. Garcia, Jesse Voss, Kevin Halling, Anthony Karnezis, Janine Senz, Winnie Yang, Elena-Sophie Prigge, Miriam Reuschenbach, Magnus Von Knebel Doeberitz, Blake C. Gilks, David G. Huntsman, Jamie Bakkum-Gamez…
    Citation: BMC Cancer 2015 15:415
    Content type: Research article Published on:

  14. Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with a dismal response to single-use of immune checkpoint inhibitors (ICIs). ICIs combined with systemic therapy has shown efficacy and safety in vari...

    Authors: Lin Shui, Ke Cheng, Xiaofen Li, Pixian Shui, Xiaohan Zhou, Jian Li, Cheng Yi and Dan Cao
    Citation: BMC Cancer 2020 20:636
    Content type: Study protocol Published on:

  16. Epithelioid hemangioendothelioma is a rare vascular tumor of borderline or low-grade malignancy. The lungs and liver are the two common primary organs affected. Metastatic disease was reported in more than 100...

    Authors: Valeriya Semenisty, Inna Naroditsky, Zohar Keidar and Gil Bar-Sela
    Citation: BMC Cancer 2015 15:402
    Content type: Case report Published on:

  17. Disulfiram and metals inactivate key oncoproteins resulting in anti-neoplastic activity. The goal of this study was to determine the maximum tolerated dose of copper when administered with disulfiram in patien...

    Authors: Kristen C. Kelley, Kenneth F. Grossman, Mary Brittain-Blankenship, Kelli M. Thorne, Wallace L. Akerley, Moises C. Terrazas, Ken M. Kosak, Kenneth M. Boucher, Saundra S. Buys, Kimberly A. McGregor, Theresa L. Werner, Neeraj Agarwal, John R. Weis, Sunil Sharma, John H. Ward, Thomas P. Kennedy…
    Citation: BMC Cancer 2021 21:510
    Content type: Research Published on:

  18. ATP-binding cassette sub-family G member 2 (ABCG2) is a semi-transport protein that plays a major role in multidrug resistance. We aimed to evaluate the prognostic significance of ABCG2 expression in patients wit...

    Authors: Haofei Wang, Fangxiu Luo, Zhe Zhu, Zhaoping Xu, Xin Huang, Renyi Ma, Hongchao He, Yu Zhu, Kun Shao and Juping Zhao
    Citation: BMC Cancer 2017 17:222
    Content type: Research article Published on:

  19. It has been suggested that a small population of cells with unique self-renewal properties and malignant potential exists in solid tumors. Such "cancer stem cells" have been isolated by flow cytometry, followe...

    Authors: Heike Immervoll, Dag Hoem, Per Øystein Sakariassen, Ole Johnny Steffensen and Anders Molven
    Citation: BMC Cancer 2008 8:48
    Content type: Research article Published on:

  20. Carcinomas of unknown primary site (CUP) are epithelial malignancies revealed by metastatic lesions in the absence of any detectable primary tumor. Although they often adopt an aggressive clinical pattern, the...

    Authors: Delphine Lequin, Karim Fizazi, Saloua Toujani, Sylvie Souquère, Marie-Christine Mathieu, Pierre Hainaut, Alain Bernheim, Françoise Praz and Pierre Busson
    Citation: BMC Cancer 2007 7:225
    Content type: Research article Published on:

  21. The oxidative stress mechanism is of particular interest in the pathogenesis of glioma, given the high rate of oxygen metabolism in the brain. Potential links between polymorphisms of antioxidant genes and gli...

    Authors: Peng Zhao, Lin Zhao, Peng Zou, Ailin Lu, Ning Liu, Wei Yan, Chunsheng Kang, Zhen Fu, Yongping You and Tao Jiang
    Citation: BMC Cancer 2012 12:617
    Content type: Research article Published on:

  22. Thymic epithelial tumors (TETs) are rare neoplasms often associated with immune-related disorders. Patients with Good’s syndrome (GS), an adult-acquired TET-related immunodeficiency, are at a high risk of mort...

    Authors: Erica Pietroluongo, Annarita Peddio, Pietro De Placido, Marianna Tortora, Margaret Ottaviano, Monica Gelzo, Gustavo Cernera, Maria Foggia, Antonio Riccardo Buonomo, Biagio Pinchera, Emanuela Zappulo, Simona Mercinelli, Letizia Cattaneo, Alessia Sardanelli, Giulio Viceconte, Riccardo Scotto…
    Citation: BMC Cancer 2024 24:748
    Content type: Research Published on:

  24. Despite positive results from large phase III clinical trials proved that it is possible to prevent estrogen-responsive breast cancers with selective estrogen receptor modulators and aromatase inhibitors, no s...

    Authors: Matteo Lazzeroni, Aliana Guerrieri-Gonzaga, Davide Serrano, Massimiliano Cazzaniga, Serena Mora, Chiara Casadio, Costantino Jemos, Maria Pizzamiglio, Laura Cortesi, Davide Radice and Bernardo Bonanni
    Citation: BMC Cancer 2012 12:575
    Content type: Study protocol Published on:

  25. Regulation of tumor microenvironment is closely involved in the prognosis of Hodgkin lymphoma (HL). Indoleamine 2,3-dioxygenase (IDO) is an enzyme acting as immune modulator through suppression of T-cell immun...

    Authors: Ji-Young Choe, Ji Yun Yun, Yoon Kyoung Jeon, Se Hoon Kim, Gyeongsin Park, Joo Ryoung Huh, Sohee Oh and Ji Eun Kim
    Citation: BMC Cancer 2014 14:335
    Content type: Research article Published on:

  26. Locally advanced or metastatic adenocarcinoma of the pancreas remains - despite the implementation of new chemotherapy protocols - a disease with short overall survival (OS).

    Authors: Ursula M. Vogl, Haleh Andalibi, Alexander Klaus, Laurenz Vormittag, Wolfgang Schima, Bettina Heinrich, Alice Kafka, Thomas Winkler and Leopold Öhler
    Citation: BMC Cancer 2019 19:28
    Content type: Research article Published on:

  27. c-Met is widely known as a poor prognostic factor in various human malignancies. Previous studies have suggested the involvement of c-Met and/or its ligand, hepatocyte growth factor (HGF), in esophageal squamo...

    Authors: Yohei Ozawa, Yasuhiro Nakamura, Fumiyoshi Fujishima, Saulo JA Felizola, Kenichiro Takeda, Hiroshi Okamoto, Ken Ito, Hirotaka Ishida, Takuro Konno, Takashi Kamei, Go Miyata, Noriaki Ohuchi and Hironobu Sasano
    Citation: BMC Cancer 2015 15:451
    Content type: Research article Published on:

  28. The molecular pathogenesis of endometrial cancer is not completely understood. CypB upregulated in many cancers, however, its role in endometrial carcinoma has not been studied. Here, we determine the effect o...

    Authors: Jing Liu, Ying Zuo, Gui-Mei Qu, Xiao Song, Zhong-Hui Liu, Ting-Guo Zhang, Zhu-Hua Zheng and Hong-Kun Wang
    Citation: BMC Cancer 2021 21:747
    Content type: Research article Published on:

  29. Intrinsic and acquired resistance to drug therapies remains a challenge for malignant melanoma patients. Intratumoral heterogeneities within the tumor microenvironment contribute additional complexity to the d...

    Authors: Anna Afasizheva, Alexus Devine, Heather Tillman, King Leung Fung, Wilfred D. Vieira, Benjamin H. Blehm, Yorihisa Kotobuki, Ben Busby, Emily I. Chen and Kandice Tanner
    Citation: BMC Cancer 2016 16:186
    Content type: Research article Published on:

  30. Neuroblastoma is the most common extra-cranial solid tumor among children. Despite intensive treatment, patients with advanced disease mostly experience dismal outcomes. Here, we proposed the use of topotecan ...

    Authors: Piya Rujkijyanont, Apichat Photia, Chanchai Traivaree, Chalinee Monsereenusorn, Usanarat Anurathapan, Panya Seksarn, Darintr Sosothikul, Piti Techavichit, Kleebsabai Sanpakit, Kamon Phuakpet, Surapon Wiangnon, Thirachit Chotsampancharoen, Su-on Chainansamit, Somjai Kanjanapongkul, Arunotai Meekaewkunchorn and Suradej Hongeng
    Citation: BMC Cancer 2019 19:961
    Content type: Research article Published on:

  31. The clinicopathological characteristics of small intestinal neuroendocrine neoplasms (SI-NENs) and the prognostic validity of WHO grading classification for SI-NENs are still unknown in Asian patients.

    Authors: Luohai Chen, Lin Zhou, Meng Zhang, Liang Shang, Panpan Zhang, Wei Wang, Cheng Fang, Jingnan Li, Tianming Xu, Huangying Tan, Pan Zhang, Meng Qiu, Xianjun Yu, Kaizhou Jin, Ye Chen, Huishan Chen…
    Citation: BMC Cancer 2017 17:521
    Content type: Research article Published on:

  32. An extremely rare condition, radiation-induced angiosarcoma is characterized by a poor prognosis, high recurrence rate and lack of effective treatment. Herein, we present a case report of a 48-year-old female ...

    Authors: Jieshan Guan, Zhijie Luo, Zhiwei Xiao, Yubin Xie and Lizhu Lin
    Citation: BMC Cancer 2019 19:1188
    Content type: Case report Published on:

  33. Neuroblastic tumours (NBTs) are paediatric solid tumours derived from embryonic neural crest cells which harbour their own cancer stem cells (CSC). There is evidence indicating that CSC may be responsible for ...

    Authors: Ezequiel Monferrer, Rebeca Burgos-Panadero, Maite Blanquer-Maceiras, Adela Cañete, Samuel Navarro and Rosa Noguera
    Citation: BMC Cancer 2019 19:1
    Content type: Research article Published on:

  34. Human papilloma virus (HPV) in patients with esophageal carcinoma has previously been studied with an average detection rate of 15%, but the role of HPV in relation to survival is less clear. In cervical cance...

    Authors: Martin Dreilich, Michael Bergqvist, Martin Moberg, Daniel Brattström, Inger Gustavsson, Stefan Bergström, Alkwin Wanders, Patrik Hesselius, Gunnar Wagenius and Ulf Gyllensten
    Citation: BMC Cancer 2006 6:94
    Content type: Research article Published on:

  35. Epidermal growth factor receptor (EGFR)-sensitizing mutation, exon 19 deletion consists of several molecular variants. Influences of these variants on clinical response to EGFR tyrosine kinase inhibitors remain e...

    Authors: Nahomi Tokudome, Yasuhiro Koh, Hiroaki Akamatsu, Daichi Fujimoto, Isamu Okamoto, Kazuhiko Nakagawa, Toyoaki Hida, Fumio Imamura, Satoshi Morita and Nobuyuki Yamamoto
    Citation: BMC Cancer 2020 20:103
    Content type: Research article Published on:

  36. Rhabdomyosarcomas (RMSs) are the most frequent soft tissue sarcoma in children and adolescents, defined by skeletal muscle differentiation and the status of FOXO1 fusions. In pediatric malignancies, in particu...

    Authors: Giulia Bertolini, Luca Bergamaschi, Andrea Ferrari, Salvatore L. Renne, Paola Collini, Cecilia Gardelli, Marta Barisella, Giovanni Centonze, Stefano Chiaravalli, Cinzia Paolino, Massimo Milione, Maura Massimino, Michela Casanova and Patrizia Gasparini
    Citation: BMC Cancer 2018 18:652
    Content type: Research article Published on:

  37. Histone deacetylase inhibitors (HDACIs) have distinctive epigenetic targets involved in hepatocarcinogenesis and chemoresistance. A recent phase I/II study reported the possibility of HDACI as a chemosensitize...

    Authors: Young Chang, Yun Bin Lee, Eun Ju Cho, Jeong-Hoon Lee, Su Jong Yu, Yoon Jun Kim and Jung-Hwan Yoon
    Citation: BMC Cancer 2020 20:1001
    Content type: Research article Published on:

  38. The prognosis of most hepatocellular carcinoma (HCC) patients is poor due to the high metastatic rate of the disease. Understanding the molecular mechanisms underlying HCC metastasis is extremely urgent. The r...

    Authors: Jin Zheng, Yan Li, Jiandong Yang, Qiang Liu, Ming Shi, Rui Zhang, Hengjun Shi, Qinyou Ren, Ji Ma, Hang Guo, Yurong Tao, Yan Xue, Ning Jiang, Libo Yao and Wenchao Liu
    Citation: BMC Cancer 2011 11:251
    Content type: Research article Published on:

  39. Fibroblast growth factor receptors (FGFRs) are well-known proto-oncogenes in several human malignancies and are currently therapeutically targeted in clinical trials. Among glioma subtypes, activating FGFR1 al...

    Authors: Birgitta Lehtinen, Annina Raita, Juha Kesseli, Matti Annala, Kristiina Nordfors, Olli Yli-Harja, Wei Zhang, Tapio Visakorpi, Matti Nykter, Hannu Haapasalo and Kirsi J. Granberg
    Citation: BMC Cancer 2017 17:310
    Content type: Research article Published on:

  40. Bone tumors account for approximately 6% of all cancers in children. Malignant bone tumors, commonly occurring in children and adolescents, are associated with high mortality and morbidity. The overall surviva...

    Authors: Temesgen Lingerih, Sewagegn Yeshiwas, Abdulkadir Mohamedsaid and Gashaw Arega
    Citation: BMC Cancer 2024 24:394
    Content type: Research Published on:

  41. Cancer cells display widespread changes in DNA methylation that may lead to genetic instability by global hypomethylation and aberrant silencing of tumor suppressor genes by focal hypermethylation. In turn, al...

    Authors: Silke Götze, Valeska Feldhaus, Thilo Traska, Marietta Wolter, Guido Reifenberger, Andrea Tannapfel, Cornelius Kuhnen, Dirk Martin, Oliver Müller and Sonja Sievers
    Citation: BMC Cancer 2009 9:447
    Content type: Research article Published on:

  42. In the widespread adoption of chemotherapy, drug resistance has been the major obstacle to tumor elimination in cancer patients. Our aim was to explore the role of TGF-β in osteosarcoma-associated chemoresista...

    Authors: Yangbo Xu, Yafei Li, Xiaofan Chen, Feifan Xiang, Yong Deng, Zhong Li and Daiqing Wei
    Citation: BMC Cancer 2021 21:1200
    Content type: Research Published on:

  43. Aberrant activity of tyrosine-phosphorylated proteins is commonly associated with HCC metastasis. Cell signaling events driven by these proteins are implicated in numerous processes that alter cancer cell beha...

    Authors: Haiyu Li, Zhenggang Ren, Xiaonan Kang, Lan Zhang, Xuefei Li, Yan Wang, Tongchun Xue, Yuefang Shen and Yinkun Liu
    Citation: BMC Cancer 2009 9:366
    Content type: Research article Published on:

  44. Autoantibodies function as markers of tumorigenesis and have been proposed to enhance early detection of malignancies. We recently reported, using immunoscreening of a T7 complementary DNA (cDNA) library of br...

    Authors: Siddhesh Aras, Marie-Claire Maroun, Yeohan Song, Sudeshna Bandyopadhyay, Azadeh Stark, Zeng-Quan Yang, Michael P. Long, Lawrence I. Grossman and Félix Fernández-Madrid
    Citation: BMC Cancer 2019 19:411
    Content type: Research article Published on:

  46. Adenoid cystic carcinoma is a high malignant carcinoma characterized by intensive local invasion and high incidence of distant metastasis. Although many reports have demonstrated that angiogenesis has played a...

    Authors: Jiali Zhang and Bin Peng
    Citation: BMC Cancer 2007 7:95
    Content type: Research article Published on:

  47. Spinal bone metastases are commonly diagnosed in cancer patients. The consequences are pain both at rest and under exercise, impairment of activities of daily life (ADL), reduced clinical performance, the risk...

    Authors: Harald Rief, Georg Omlor, Michael Akbar, Thomas Welzel, Thomas Bruckner, Stefan Rieken, Matthias F Haefner, Ingmar Schlampp, Alexandros Gioules, Daniel Habermehl, Friedbert von Nettelbladt and Jürgen Debus
    Citation: BMC Cancer 2014 14:67
    Content type: Research article Published on:

  48. The incidence of papillary thyroid carcinoma (PTC) has been increasing worldwide in recent years. Therefore, novel potential therapeutic targets for PTC are urgently needed. Enhancer of zeste homolog 2 (EZH2),...

    Authors: Liqiong Xue, Hongzhu Yan, Ying Chen, Qifa Zhang, Xin Xie, Xiaoying Ding, Xiaojing Wang, Zhongqing Qian, Feng Xiao, Zhiyi Song, Yijie Wu, Yongde Peng and Huanbai Xu
    Citation: BMC Cancer 2019 19:1094
    Content type: Research article Published on:

  49. Glioma is a primary brain tumor and the assessment of its molecular profile in a minimally invasive manner is important in determining treatment strategies. Among the molecular abnormalities of gliomas, mutati...

    Authors: Saiko Kino, Masayuki Kanamori, Yoshiteru Shimoda, Kuniyasu Niizuma, Hidenori Endo and Yuji Matsuura
    Citation: BMC Cancer 2024 24:222
    Content type: Research Published on:

  50. Phenethyl isothiocyanate (PEITC) is a cancer chemopreventive agent from cruciferous vegetables. Cholangiocarcinoma (CCA) is a chemo-resistant cancer with very poor prognosis. We evaluated the effects of PEITC ...

    Authors: Ornanong Tusskorn, Laddawan Senggunprai, Auemduan Prawan, Upa Kukongviriyapan and Veerapol Kukongviriyapan
    Citation: BMC Cancer 2013 13:571
    Content type: Research article Published on:

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