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  1. Shear wave elastography can evaluate tissue stiffness. Previous studies showed that the elasticity characteristics of breast lesions were related to the components of extracellular matrix which was regulated b...

    Authors: Meng Ke Zhang, Bo Wang, Shi Yu Li, Gang Liu and Zhi Li Wang
    Citation: BMC Cancer 2021 21:1336
    Content type: Research Published on:

  3. Neoadjuvant therapy followed by surgery is recommended for locally advanced esophageal cancer. With the inaccuracies of clinical staging particularly for cT1N+ and cT2Nany tumors, some have proposed considerat...

    Authors: Binhao Huang, Ernest G. Chan, Arjun Pennathur, James D. Luketich and Jie Zhang
    Citation: BMC Cancer 2021 21:1334
    Content type: Research article Published on:

  4. The optimal treatment of stage IV rectal cancer remains controversial. The purpose of this study was to assess the treatment outcomes and toxicity of neoadjuvant chemotherapy and radiotherapy followed by local...

    Authors: Rongzhen Li, Qiaoxuan Wang, Bin Zhang, Yan Yuan, Weihao Xie, Xiaoxue Huang, Chengjing Zhou, Shu Zhang, Shaoqing Niu, Hui Chang, Dongni Chen, Huikai Miao, Zhi Fan Zeng, Weiwei Xiao and Yuanhong Gao
    Citation: BMC Cancer 2021 21:1333
    Content type: Research Published on:

  5. Adjuvant chemotherapy reduces the risk of recurrence of stage III colon cancer (CC). However, more effective prognostic and predictive biomarkers are needed for better treatment stratification of affected pati...

    Authors: Eiji Oki, Eiji Shinto, Mototsugu Shimokawa, Shigeki Yamaguchi, Megumi Ishiguro, Seiji Hasegawa, Yasumasa Takii, Hideyuki Ishida, Tetsuya Kusumoto, Masaru Morita, Naohiro Tomita, Manabu Shiozawa, Masafumi Tanaka, Heita Ozawa, Yojiro Hashiguchi, Shinobu Ohnuma…
    Citation: BMC Cancer 2021 21:1332
    Content type: Research Published on:

  6. The clinical outcome of Philadelphia chromosome-negative B cell acute lymphoblastic leukemia (Ph-neg B-ALL) varies considerably from one person to another after clinical treatment due to lack of targeted thera...

    Authors: Yang Hong, Ling Zhang, Xiaopeng Tian, Xin Xiang, Yan Yu, Zhao Zeng, Yaqing Cao, Suning Chen and Aining Sun
    Citation: BMC Cancer 2021 21:1331
    Content type: Research article Published on:

  7. We investigated the clinicopathological characteristics and survival of breast cancer lung metastases (BCLM) patients at initial diagnosis of metastatic breast cancer (MBC) in the Han population.

    Authors: Shaoyan Lin, Hongnan Mo, Yiqun Li, Xiuwen Guan, Yimeng Chen, Zijing Wang and Binghe Xu
    Citation: BMC Cancer 2021 21:1330
    Content type: Research Published on:

  8. Glucose metabolism in cancer associated fibroblasts (CAFs) within the tumor microenvironment is a material and energy source for tumorigenesis and tumor development. However, the characteristics and important ...

    Authors: Li Xiao, Qiannan Hu, Yanshuang Peng, Kaiyue Zheng, Ting Zhang, Lianjie Yang, Zhi Wang, Wanrong Tang, Jie Yu, Qian Xiao, Dandan Zhang, Weifang Zhang, Chanjuan He, Dengxun Wu, Yanyan Zheng and Ying Liu
    Citation: BMC Cancer 2021 21:1329
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2021 21:1355

  9. To investigate the differences between doublet and triplet neoadjuvant chemotherapy (NAC) regimens in efficacy and safety profile.

    Authors: Yonghe Chen, Jiasheng He, Dan Liu, Jian Xiao, Xijie Chen, Haijie Tang, Dandong Luo, Chenyu Shang, Lei Lian and Junsheng Peng
    Citation: BMC Cancer 2021 21:1328
    Content type: Research Published on:

  11. Survival times differ among patients with advanced gastric carcinoma. A precise and universal prognostic evaluation strategy has not yet been established. The current study aimed to construct a prognostic scor...

    Authors: Tai Ma, Zhijun Wu, Xiaopeng Zhang, Hui Xu, Ying Feng, Cheng Zhang, Minmin Xie, Yahui Yang, Yi Zhang, Chong Feng and Guoping Sun
    Citation: BMC Cancer 2021 21:1326
    Content type: Research Published on:

  12. Colorectal cancer (CRC) is still one of the most common types of cancer in the world, and the gut microbiome plays an important role in its development. The microbiome is involved in the carcinogenesis, format...

    Authors: Martina Rebersek
    Citation: BMC Cancer 2021 21:1325
    Content type: Review Published on:

  13. Advanced gastric cancer (AGC) is a disease with poor prognosis due to the current lack of effective therapeutic strategies. Immune checkpoint blockade treatments have shown effective responses in patient subgr...

    Authors: Simeng Zhang, Mengzhu Lv, Yu Cheng, Shuo Wang, Ce Li and Xiujuan Qu
    Citation: BMC Cancer 2021 21:1324
    Content type: Research Published on:

  14. Numerous studies have examined catastrophic health expenditures (CHE) worldwide, mostly focusing on general or common chronic populations, rather than particularly vulnerable groups. This study assessed the me...

    Authors: Cheng-yao Sun, Ju-fang Shi, Wen-qi Fu, Xin Zhang, Guo-xiang Liu, Wan-qing Chen and Jie He
    Citation: BMC Cancer 2021 21:1323
    Content type: Research Published on:

  17. To evaluate the prognostic value of the apparent diffusion coefficient (ADC) derived from diffusion-weighted magnetic resonance imaging (MRI) and monitor the early treatment response to induction chemotherapy ...

    Authors: Li-Ting Liu, Shan-Shan Guo, Hui Li, Chao Lin, Rui Sun, Qiu-Yan Chen, Yu-Jing Liang, Qing-Nan Tang, Xue-Song Sun, Lin-Quan Tang, Chuan-Miao Xie and Hai-Qiang Mai
    Citation: BMC Cancer 2021 21:1320
    Content type: Research Published on:

  18. The prognosis of pancreatic cancer (PC) has been improved by new chemotherapy regimens (combination of 5-fluorouracil, oxaliplatin, irinotecan, and leucovorin (FOLFIRINOX) or gemcitabine plus nab-paclitaxel (G...

    Authors: Mitsuru Sugimoto, Tadayuki Takagi, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Yuki Sato, Hiroki Irie, Yoshinori Okubo, Jun Nakamura, Mika Takasumi, Minami Hashimoto, Tsunetaka Kato, Ryoichiro Kobashi, Takuto Hikichi and Hiromasa Ohira
    Citation: BMC Cancer 2021 21:1319
    Content type: Research Published on:

  20. Platelet distribution width (PDW) and red cell distribution width (RDW) are readily obtainable data, and are reportedly useful as prognostic indicators in some cancers. However, their prognostic significance i...

    Authors: Hiroaki Saito, Shota Shimizu, Yuji Shishido, Kozo Miyatani, Tomoyuki Matsunaga and Yoshiyuki Fujiwara
    Citation: BMC Cancer 2021 21:1317
    Content type: Research Published on:

  21. Overcoming drug resistance is critical for increasing the survival rate of prostate cancer (PCa). Docetaxel is the first cytotoxic chemotherapeutical approved for treatment of PCa. However, 99% of PCa patients...

    Authors: Patricia M. Schnepp, Aqila Ahmed, June Escara-Wilke, Jinlu Dai, Greg Shelley, Jill Keller, Atsushi Mizokami and Evan T. Keller
    Citation: BMC Cancer 2021 21:1316
    Content type: Research Published on:

  22. Flow cytometry (FC) is a popular method to detect bone marrow (BM) involvement in patients with B-cell non-Hodgkin lymphoma (B-NHL). The majority of screen panels of FC still rely on finding monoclonal B-cells...

    Authors: Wei Wang, Yan Li, Haval Ali, Linjun Zhao, Di Mei, Wenqing Hu and Bin Jiang
    Citation: BMC Cancer 2021 21:1315
    Content type: Research Published on:

  23. The population-based survival rate is affected by the quality and effectiveness of health care systems. Overall, the survival of prostate cancer (PC) patients has improved over the past two decades worldwide. ...

    Authors: Mohammad Aziz Rasouli, Ghobad Moradi, Bushra Zareie, Heshmatollah Sofimajidpour, Sima Tozandehjani, Hedyeh Zafari, Fatemeh Gholami, Sonia Shahsavari, Parisa Hassani and Mahshid Mohammadian
    Citation: BMC Cancer 2021 21:1314
    Content type: Research Published on:

  24. The prognostic value of a low skeletal mass index (SMI) has been investigated in locally advanced oesophageal (LAE) cancer at diagnosis. However, nothing is known about its evolution and clinical impact betwee...

    Authors: Yacine Zouhry, Abdelkader Taibi, Sylvaine Durand-Fontanier, Tiffany Darbas, Geraud Forestier, Jacques Monteil, Valérie Lebrun-Ly, Philippe Fayemendy, Sophie Leobon, Pierre Jesus and Elise Deluche
    Citation: BMC Cancer 2021 21:1313
    Content type: Research Published on:

  26. Glioma is the most common primary intracranial tumour and has a very poor prognosis. Pyroptosis, also known as inflammatory necrosis, is a type of programmed cell death that was discovered in recent years. The...

    Authors: Moxuan Zhang, Yanhao Cheng, Zhengchun Xue, Qiang Sun and Jian Zhang
    Citation: BMC Cancer 2021 21:1311
    Content type: Research Published on:

  27. Abundant evidence has manifested that long noncoding RNAs (lncRNAs) are closely implicated in human cancers, including hepatocellular carcinoma (HCC). Remarkably, lncRNA FAM83H antisense RNA 1 (FAM83H-AS1) has...

    Authors: Wenpeng Zhao, Jiang Guo, Honglu Li, Liang Cai, Youjia Duan, Xiaopu Hou, Zhenying Diao, Xihong Shao, Hongliu Du and Changqing Li
    Citation: BMC Cancer 2021 21:1310
    Content type: Research article Published on:

  28. Treatment of clinical N0 neck tumours is controversial in early-stage oral squamous cell carcinoma (OSCC), possibly because T1N0M0 and T2N0M0 merge together at early stages. The purposes of this study were to ...

    Authors: Alimujiang Wushou, Feiluore Yibulayin, Lu Sheng, Yuan Luo and Zhi-cheng Yang
    Citation: BMC Cancer 2021 21:1309
    Content type: Research article Published on:

  29. Extensive-stage small cell lung cancer (ES-SCLC) is an aggressive disease with poor survival, and platinum-etoposide chemotherapy is indicated as the mainstay of treatment. In this study, we compared the effic...

    Authors: Shiyu Jiang, Liling Huang, Hongnan Zhen, Peijie Jin, Jing Wang and Zhihuang Hu
    Citation: BMC Cancer 2021 21:1308
    Content type: Research Published on:

  30. Esophageal squamous cell carcinoma (ESCC) is the most predominant primary malignant tumor among worldwide, especially in China. To date, the successful treatment remains a mainly clinical challenge, it is impe...

    Authors: Nana Xu, Mengmeng Lu, Jiaxin Wang, Yujia Li, Xiaotian Yang, Xiajie Wei, Jiaoyang Si, Jingru Han, Xiaojuan Yao, Juanmei Zhang, Junqi Liu, Yanming Li, Hushan Yang and Dengke Bao
    Citation: BMC Cancer 2021 21:1307
    Content type: Research Published on:

  31. To examine the prevalence and prognostic role of tumor microenvironment (TME) markers in uterine carcinosarcoma (UCS) through immunohistochemical characterization.

    Authors: Jesse Lopes da Silva, Lucas Zanetti de Albuquerque, Fabiana Resende Rodrigues, Guilherme Gomes de Mesquita, Cláudia Bessa Pereira Chaves, Martín Hernán Bonamino and Andreia Cristina de Melo
    Citation: BMC Cancer 2021 21:1306
    Content type: Research Published on:

  32. The expression and activation of eukaryotic translation initiation factor 4E (eIF4E) is associated with cell transformation and tumor initiation, but the functional role and the mechanism whereby it drives imm...

    Authors: Fan Li, Huizhi Sun, Yue Li, Xiaoyu Bai, Xueyi Dong, Nan Zhao, Jie Meng, Baocun Sun and Danfang Zhang
    Citation: BMC Cancer 2021 21:1305
    Content type: Research Published on:

  33. Studies suggest a high prevalence of pain in head and neck cancer (HNC) patients at diagnosis, during and after treatment; however, these studies had small sample sizes and did not comprehensively assess facto...

    Authors: Jenny L. Ren, Raniv D. Rojo, Joy Vanessa D. Perez, Sai-Ching J. Yeung, Ehab Y. Hanna and Cielito C. Reyes-Gibby
    Citation: BMC Cancer 2021 21:1304
    Content type: Research Published on:

  34. There is no unified treatment standard for patients with extranodal NK/T-cell lymphoma (ENKTL). Cancer neoantigens are the result of somatic mutations and cancer-specific. Increased number of somatic mutations...

    Authors: Yang Wang, Huaicheng Tan, Ting Yu, Xuelei Ma, Xiaoxuan Chen, Fangqi Jing, Liqun Zou and Huashan Shi
    Citation: BMC Cancer 2021 21:1303
    Content type: Research Published on:

  35. Currently, no available coherent management protocol exists for pediatric cancers associated with pleural effusion, ascites, and pericardial effusion. This study aimed to retrospectively present our experience...

    Authors: Yu-Tong Zhang, Xiao-dan Zhong, Yan-li Gao and Jian Chang
    Citation: BMC Cancer 2021 21:1302
    Content type: Research Published on:

  36. Pegylated liposomal doxorubicin (PLD) is an improved formulation of doxorubicin with comparable effectiveness but significantly lower cardiotoxicity than conventional anthracycline. This study aimed to evaluat...

    Authors: Jin Zhang, Hongchuan Jiang, Jian Zhang, Guoqiang Bao, Guoqiang Zhang, Haibo Wang and Xi Wang
    Citation: BMC Cancer 2021 21:1301
    Content type: Research Published on:

  37. Immune-related adverse events (irAEs) are a major toxicity of immune checkpoint inhibitors. Studies have reported that pre-existing autoimmunity increases the risk of irAEs, but it remains unknown which clinic...

    Authors: Aaron N. Holmes, Helen Swede, Wendy M. Feer, Donna Comins Pike, Xiaoyan Wang and Upendra P. Hegde
    Citation: BMC Cancer 2021 21:1300
    Content type: Research Published on:

  38. At present, hepatectomy is still the most common and effective treatment method for intrahepatic cholangiocarcinoma (ICC) patients. However, the postoperative prognosis is poor. Therefore, the prognostic facto...

    Authors: Yifan Chen, Hongzhi Liu, Jinyu Zhang, Yijun Wu, Weiping Zhou, Zhangjun Cheng, Jianying Lou, Shuguo Zheng, Xinyu Bi, Jianming Wang, Wei Guo, Fuyu Li, Jian Wang, Yamin Zheng, Jingdong Li, Shi Cheng…
    Citation: BMC Cancer 2021 21:1299
    Content type: Research Published on:

  39. Although a significant association between air pollution and mental health has been identified, few studies have addressed this relationship based on cancer diagnosis. This study investigated whether associati...

    Authors: Hyun-Jin Kim, Jin-young Min, Yong-Seok Seo and Kyoung-bok Min
    Citation: BMC Cancer 2021 21:1298
    Content type: Research article Published on:

  40. Colorectal cancer is a malignant gastrointestinal cancer, in which some advanced patients would develop cancer cachexia (CAC). CAC is defined as a multi-factorial syndrome characterized by weight loss and musc...

    Authors: Lingbi Jiang, Mingming Yang, Shihui He, Zhengyang Li, Haobin Li, Ting Niu, Dehuan Xie, Yan Mei, Xiaodong He, Lili Wei, Pinzhu Huang, Mingzhe Huang, Rongxin Zhang, Lijing Wang and Jiangchao Li
    Citation: BMC Cancer 2021 21:1297
    Content type: Research article Published on:

  41. Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BC). Treatment options for TNBC patients are limited and further insights into disease aetiology are needed to develop bett...

    Authors: Chiara Giacomelli, Janine Jung, Astrid Wachter, Susanne Ibing, Rainer Will, Stefan Uhlmann, Heiko Mannsperger, Özgür Sahin, Yosef Yarden, Tim Beißbarth, Ulrike Korf, Cindy Körner and Stefan Wiemann
    Citation: BMC Cancer 2021 21:1296
    Content type: Research article Published on:

  42. Sexual problems are frequently reported after treatment with radiotherapy (RT) for gynaecological cancer (GC), in particular after combined external beam radiotherapy and brachytherapy (EBRT+BT). Studies demon...

    Authors: Isabelle Suvaal, Susanna B. Hummel, Jan-Willem M. Mens, Helena C. van Doorn, Wilbert B. van den Hout, Carien L. Creutzberg and Moniek M. ter Kuile
    Citation: BMC Cancer 2021 21:1295
    Content type: Study protocol Published on:

  43. Wilms tumor is a highly heritable malignancy. Aberrant METTL14, a critical component of N6-methyladenosine (m6A) methyltransferase, is involved in carcinogenesis. The association between genetic variants in the M...

    Authors: Zhenjian Zhuo, Rui-Xi Hua, Huizhu Zhang, Huiran Lin, Wen Fu, Jinhong Zhu, Jiwen Cheng, Jiao Zhang, Suhong Li, Haixia Zhou, Huimin Xia, Guochang Liu, Wei Jia and Jing He
    Citation: BMC Cancer 2021 21:1294
    Content type: Research Published on:

  44. Bladder cancer (BC) is one of the most common malignancies globally. Early diagnosis of it can significantly improve patients’ survival and quality of life. Urinary exosomes (UEs)-derived miRNAs might be a pro...

    Authors: Hao Lin, Xiaojun Shi, Haoran Li, Jialiang Hui, Ruiyu Liu, Zihao Chen, Yuwen Lu and Wanlong Tan
    Citation: BMC Cancer 2021 21:1293
    Content type: Research Published on:

  45. Cisplatin-based neoadjuvant chemotherapy (NAC) followed by surgery is the standard treatment for patients with non-metastatic muscle invasive bladder cancer (MIBC). Unfortunately, many patients are not candida...

    Authors: Nieves Martinez Chanza, Louisa Soukane, Philippe Barthelemy, Aurélien Carnot, Thierry Gil, Vinciane Casert, Vincent Vanhaudenarde, Brieuc Sautois, Lionel Staudacher, Jan Van den Brande, Stephane Culine, Emmanuel Seront, Marco Gizzi, Simone Albisinni, Thibault Tricard, Jean Christophe Fantoni…
    Citation: BMC Cancer 2021 21:1292
    Content type: Study protocol Published on:

  46. Authors: Shebli Atrash, Philippe Thompson-Leduc, Ming-Hui Tai, Shuchita Kaila, Kathleen Gray, Isabelle Ghelerter, Marie-Hélène Lafeuille, Patrick Lefebvre and Adriana Rossi
    Citation: BMC Cancer 2021 21:1291
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2021 21:1207

  47. RNA cargo in exosomes, especially microRNAs (miRNAs), play an important role in the chemotherapy drug resistance of human cancers. However, the role and mechanism of exosomal miR-107 on multidrug resistance of...

    Authors: Lu Jiang, Yan Zhang, Linghui Guo, Chaoyang Liu, Pan Wang and Weihong Ren
    Citation: BMC Cancer 2021 21:1290
    Content type: Research Published on:

  48. The role of circular RNAs (circRNAs) in the occurrence and development of gastric cancer (GC) has recently attracted increasing interest. The following study investigates the role of a newly discovered hsa_cir...

    Authors: Xin Xu, Shoulian Wang, Haibo Wang, Chunpeng Pan, Wenyan Yang and Jiwei Yu
    Citation: BMC Cancer 2021 21:1289
    Content type: Research Published on:

  50. Breast cancer screening is currently predominantly based on mammography, tainted with the occurrence of both false positivity and false negativity, urging for innovative strategies, as effective detection of e...

    Authors: Kosmas V. Kepesidis, Masa Bozic-Iven, Marinus Huber, Nashwa Abdel-Aziz, Sharif Kullab, Ahmed Abdelwarith, Abdulrahman Al Diab, Mohammed Al Ghamdi, Muath Abu Hilal, Mohun R. K. Bahadoor, Abhishake Sharma, Farida Dabouz, Maria Arafah, Abdallah M. Azzeer, Ferenc Krausz, Khalid Alsaleh…
    Citation: BMC Cancer 2021 21:1287
    Content type: Research Published on:

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