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  1. Eribulin methylate (eribulin) improved the overall survival (OS) of eribulin-treated patients with HER2-negative advanced breast cancer (ABC) in prospective and retrospective studies. However, the effect of er...

    Authors: Shogo Nakamoto, Junichiro Watanabe, Shoichiro Ohtani, Satoshi Morita and Masahiko Ikeda
    Citation: BMC Cancer 2022 22:31
    Content type: Research article Published on:

  2. Breast cancer (BC) is the most common malignancy in women, in whom it reaches 20% of the total neoplasia incidence. Most BCs are considered sporadic and a number of factors, including familiarity, age, hormona...

    Authors: Maria Valeria Esposito, Bruno Fosso, Marcella Nunziato, Giorgio Casaburi, Valeria D’Argenio, Alessandra Calabrese, Massimiliano D’Aiuto, Gerardo Botti, Graziano Pesole and Francesco Salvatore
    Citation: BMC Cancer 2022 22:30
    Content type: Research article Published on:

  3. To investigate the prognostic value of derived neutrophil to lymphocyte ratio (dNLR) and lactate dehydrogenase (LDH) in patients with advanced HER2 positive breast cancer treated with trastuzumab emtansine.

    Authors: Liru Li, Lin Ai, Lin Jia, Lei Zhang, Boya Lei and Qingyuan Zhang
    Citation: BMC Cancer 2022 22:29
    Content type: Research Published on:

  4. PHI-101 is an orally available, selective checkpoint kinase 2 (Chk2) inhibitor. PHI-101 has shown anti-tumour activity in ovarian cancer cell lines and impaired DNA repair pathways in preclinical experiments. ...

    Authors: Soo Jin Park, Suk-Joon Chang, Dong Hoon Suh, Tae Wook Kong, Heekyoung Song, Tae Hun Kim, Jae-Weon Kim, Hee Seung Kim and Sung-Jong Lee
    Citation: BMC Cancer 2022 22:28
    Content type: Study protocol Published on:

  5. The role of young age (< 40 years) at diagnosis as an independent risk factor for adverse outcomes in female patients with breast cancer has been highlighted in several studies. In this prospective study, we a...

    Authors: Youssef Bouferraa, Yolla Haibe, Andrea Chedid, Elio Jabra, Maya Charafeddine, Sally Temraz, Deborah Mukherji, Nagi El Saghir and Ali Shamseddine
    Citation: BMC Cancer 2022 22:27
    Content type: Research Published on:

  6. Breast cancer incidence in Northern Thailand has shown a continuous increase since records began in 1983. In 2002 the urgency of the situation prompted Maharaj Nakorn Chiang Mai Hospital to initiate the Suando...

    Authors: Imjai Chitapanarux, Wimrak Onchan, Panchaporn Wongmaneerung, Areewan Somwangprasert, Nongnuch Bunyoo, Chagkrit Ditsatham, Kirati Watcharachan, Chaiyut Charoentum, Patumrat Sripan, Ausreeya Chumachote and Puttachart Maneesai
    Citation: BMC Cancer 2022 22:26
    Content type: Research article Published on:

  7. Lower limb lymphedema (LLL) is one of the most refractory and debilitating complications related to gynecological cancer treatment. We investigated factors associated with response to compression-based physica...

    Authors: Masato Yoshihara, Kaoru Kitamura, Satoko Tsuru, Ryoko Shimono, Hiromi Sakuda, Michinori Mayama, Sho Tano, Kaname Uno, Mayu Ohno Ukai, Yasuyuki Kishigami, Hidenori Oguchi and Akio Hirota
    Citation: BMC Cancer 2022 22:25
    Content type: Research Published on:

  8. The aim of this study was to analyze the level of CD33 expression in patients with newly diagnosed AML and determine its correlation with clinical characteristics.

    Authors: Jingjing Liu, Jiayin Tong and Haiping Yang
    Citation: BMC Cancer 2022 22:24
    Content type: Research article Published on:

  9. Pancreatic ductal adenocarcinoma (PDAC), one of the most lethal malignancies, is increasing in incidence. However, the stromal reaction pathophysiology and its role in PDAC development remain unknown. We, therefo...

    Authors: Taija Korpela, Ari Ristimäki, Marianne Udd, Tiina Vuorela, Harri Mustonen, Caj Haglund, Leena Kylänpää and Hanna Seppänen
    Citation: BMC Cancer 2022 22:23
    Content type: Research Published on:

  10. Although nivolumab (anti-programmed cell death-1 antibody) is a promising approach for advanced gastric cancer (AGC), the response rate remains limited. The aim of this multicenter retrospective study was to d...

    Authors: Akihiko Sano, Makoto Sohda, Nobuhiro Nakazawa, Yasunari Ubukata, Kengo Kuriyama, Akiharu Kimura, Norimichi Kogure, Hisashi Hosaka, Atsushi Naganuma, Masanori Sekiguchi, Kana Saito, Kyoichi Ogata, Makoto Sakai, Hiroomi Ogawa, Ken Shirabe and Hiroshi Saeki
    Citation: BMC Cancer 2022 22:22
    Content type: Research article Published on:

  11. Considering that exposure to sunlight in childhood and adolescence has an important role in skin cancer, so it seems that training protective behaviors in this period is more effective.

    Authors: Ali Khani Jeihooni, Somayeh Bashti, Bahareh Erfanian, Jeyran Ostovarfar and Pooyan Afzali Hasirini
    Citation: BMC Cancer 2022 22:21
    Content type: Research Published on:

  12. Several studies have demonstrated that the preoperative Glasgow prognostic score (GPS) and modified GPS (mGPS) reflected the prognosis in patients undergoing curative surgery for colorectal cancer. However, th...

    Authors: Kenta Kasahara, Masanobu Enomoto, Ryutaro Udo, Tomoya Tago, Junichi Mazaki, Tetsuo Ishizaki, Tesshi Yamada, Yuichi Nagakawa, Kenji Katsumata and Akihiko Tsuchida
    Citation: BMC Cancer 2022 22:20
    Content type: Research Published on:

  13. No reliable nomogram has been developed until date for predicting the survival in patients with unresectable pancreatic cancer undergoing treatment with gemcitabine plus nab–paclitaxel (GnP) or FOLFIRINOX.

    Authors: Taro Shibuki, Toshihiko Mizuta, Mototsugu Shimokawa, Futa Koga, Yujiro Ueda, Junichi Nakazawa, Azusa Komori, Satoshi Otsu, Shiho Arima, Masaru Fukahori, Akitaka Makiyama, Hiroki Taguchi, Takuya Honda, Kenji Mitsugi, Kenta Nio, Yasushi Ide…
    Citation: BMC Cancer 2022 22:19
    Content type: Research article Published on:

  14. BRCA gene mutations (BRCAm) have an impact on patients’ characteristics and clinical outcomes of ovarian cancer (OC). The frequency and patterns of BRCAm vary among countries and ethnicities. There are limited d...

    Authors: Naela Agha, Bader Alshamsan, Sharifa Al-Farsi, Heba Aly Ateya, Fahad A. Almugbel, Hazem Abdullah Alotaibi, Ayman Omar, Amgad Shahin Mohamed, Hanan Alharthy, Tusneem Elhassan, Hany Salem and Hamed Alhusaini
    Citation: BMC Cancer 2022 22:18
    Content type: Research article Published on:

  15. Human papillomavirus (HPV)-associated oropharyngeal cancer (OPC) has a favorable prognosis which has led to efforts to de-intensify treatment. Response-adaptive de-escalated treatment is promising, however imp...

    Authors: Ari J. Rosenberg, Evgeny Izumchenko, Alexander Pearson, Zhen Gooi, Elizabeth Blair, Theodore Karrison, Aditya Juloori, Daniel Ginat, Nicole Cipriani, Mark Lingen, Hillary Sloane, Daniel L. Edelstein, Kirsten Keyser, Johannes Fredebohm, Frank Holtrup, Frederick S. Jones…
    Citation: BMC Cancer 2022 22:17
    Content type: Study protocol Published on:

  16. Cancer-related fatigue (CRF) is one of the most common and distressing complaints reported by cancer patients during chemotherapy considerably impacting all aspects of a patient’s life (physical, psychosocial,...

    Authors: Aline Hajj, Rami Chamoun, Pascale Salameh, Rita Khoury, Roula Hachem, Hala Sacre, Georges Chahine, Joseph Kattan and Lydia Rabbaa Khabbaz
    Citation: BMC Cancer 2022 22:16
    Content type: Research Published on:

  17. Personalized and effective treatments for pancreatic ductal adenocarcinoma (PDAC) continue to remain elusive. Novel clinical trial designs that enable continual and rapid evaluation of novel therapeutics are n...

    Authors: Julia E. Douglas, Suyu Liu, Junsheng Ma, Robert A. Wolff, Shubham Pant, Anirban Maitra, Eric P. Tamm, Priya Bhosale, Matthew H. G. Katz, Gauri R. Varadhachary and Eugene J. Koay
    Citation: BMC Cancer 2022 22:14
    Content type: Study protocol Published on:

  18. DNA repair deficiencies are characteristic of cancer and homologous recombination deficiency (HRD) is the most common. HRD sensitizes tumour cells to PARP inhibitors so it is important to understand the landsc...

    Authors: Zhongwu Lai, Matthew Brosnan, Ethan S. Sokol, Mingchao Xie, Jonathan R. Dry, Elizabeth A. Harrington, J. Carl Barrett and Darren Hodgson
    Citation: BMC Cancer 2022 22:13
    Content type: Research Published on:

  19. There is a long-time unmet need for a means to detect breast cancer (BC) using blood. Although mammography is accepted as the gold standard for screening, a blood-based diagnostic can complement mammography an...

    Authors: Youn Ju Lee, Young Kim, Bo Bae Choi, Je Ryong Kim, Hye Mi Ko, Kyoung Hoon Suh and Jin Sun Lee
    Citation: BMC Cancer 2022 22:12
    Content type: Research article Published on:

  20. The mixed-lineage leukemia (MLL) gene is located on chromosome 11q23. The MLL gene can be rearranged to generate partial tandem duplications (MLL-PTD), which occurs in about 5-10% of acute myeloid leukemia (AML) ...

    Authors: Jun Kong, Meng-Ge Gao, Ya-Zhen Qin, Yu Wang, Chen-Hua Yan, Yu-Qian Sun, Ying-Jun Chang, Lan-Ping Xu, Xiao-Hui Zhang, Kai-Yan Liu, Xiao-Jun Huang and Xiao-Su Zhao
    Citation: BMC Cancer 2022 22:11
    Content type: Research Published on:

  21. New evidence from clinical and fundamental researches suggests that SNHG7 is involved in the occurrence and development of carcinomas. And the increased levels of SNHG7 are associated with poor prognosis in va...

    Authors: Yunyuan Zhang, Qingwu Tian, Shifeng Huang, Qing Wang, Hongmei Wu, Qian Dong and Xian Chen
    Citation: BMC Cancer 2022 22:10
    Content type: Research Published on:

  22. We sought to understand the clinical course and molecular phenotype of patients who showed disease progression after programmed cell death ligand 1 (PD-L1) inhibitor treatment but subsequently responded to PD-...

    Authors: Xi Chen, Haiying Kong, Linxiang Luo, Shuiyun Han, Tao Lei, Haifeng Yu, Na Guo, Cong Li, Shuailing Peng, Xiaowu Dong, Haiyan Yang and Meijuan Wu
    Citation: BMC Cancer 2022 22:9
    Content type: Research Published on:

  24. The ratio of serum apolipoprotein B (apoB) to apolipoprotein A-I (apoAI) had been reported as a prognostic factor in colorectal cancer. This retrospective study aimed to assess the implication of apoB-to-apoAI...

    Authors: Chen Chen, Wei Yi, Zhi-fan Zeng, Qiao-xuan Wang, Wu Jiang, Yuan-hong Gao and Hui Chang
    Citation: BMC Cancer 2022 22:7
    Content type: Research Published on:

  26. Intrahepatic cholangiocarcinoma (ICC) is a type of malignant tumor ranking the second in the incidence of primary liver cancer following hepatocellular carcinoma. Both the morbidity and mortality have been inc...

    Authors: Guanran Zhang, Xuyue Liu, Zhengyang Sun, Xiaoning Feng, Haiyan Wang, Jing Hao and Xiaoli Zhang
    Citation: BMC Cancer 2022 22:5
    Content type: Research Published on:

  28. Older patients are underrepresented in the clinical trials that determine the standards of care for oncological treatment. We conducted a review to identify whether there have been age-restrictive inclusion cr...

    Authors: Maeve A. Hennessy, Munzir Hamid, Niamh M. Keegan, Lynda Corrigan, Caitriona Goggin, Nay Myo Oo, Marie Carrigan, David Mockler, Anita O’Donovan and Anne M. Horgan
    Citation: BMC Cancer 2022 22:3
    Content type: Research Published on:

  29. Oncogenic metabolic reprogramming contributes to tumor growth and immune evasion. The intertumoral metabolic heterogeneity and interaction of distinct metabolic pathways may determine patient outcomes. In this...

    Authors: Yuying Zhang, Baoyi Zhu, Yi Cai, Sihua Zhu, Hongjun Zhao, Xiaoling Ying, Chonghe Jiang and Jianwen Zeng
    Citation: BMC Cancer 2022 22:2
    Content type: Research Published on:

  30. It is of great urgency to explore useful prognostic markers for patients with clear cell renal cell carcinoma (ccRCC). Prognostic models based on ferroptosis-related gene (FRG) in ccRCC is poorly reported for ...

    Authors: Siteng Chen, Encheng Zhang, Tuanjie Guo, Jialiang Shao, Tao Wang, Ning Zhang, Xiang Wang and Junhua Zheng
    Citation: BMC Cancer 2022 22:1
    Content type: Research Published on:

  31. The majority of breast cancer patients are severely psychologically affected by breast cancer diagnosis and subsequent therapeutic procedures. The COVID-19 pandemic and associated restrictions on public life h...

    Authors: Catharina Bartmann, Leah-Maria Fischer, Theresa Hübner, Max Müller-Reiter, Achim Wöckel, Rhiannon V. McNeill, Tanja Schlaiss, Sarah Kittel-Schneider, Ulrike Kämmerer and Joachim Diessner
    Citation: BMC Cancer 2021 21:1356
    Content type: Research Published on:

  32. Authors: Li Xiao, Qiannan Hu, Yanshuang Peng, Kaiyue Zheng, Ting Zhang, Lianjie Yang, Zhi Wang, Wanrong Tang, Jie Yu, Qian Xiao, Dandan Zhang, Weifang Zhang, Chanjuan He, Dengxun Wu, Yanyan Zheng and Ying Liu
    Citation: BMC Cancer 2021 21:1355
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2021 21:1329

  33. Patients with multiple myeloma (MM) were excluded from the original SARS-CoV-2 mRNA vaccine trials, which may influence vaccine hesitancy in this population. We prospectively characterized the safety and immun...

    Authors: Ross S. Greenberg, Jake A. Ruddy, Brian J. Boyarsky, William A. Werbel, Jacqueline M. Garonzik-Wang, Dorry L. Segev and Philip H. Imus
    Citation: BMC Cancer 2021 21:1354
    Content type: Research Published on:

  34. The association between specific bacteria and colorectal cancer (CRC) has been proposed. Only a few studies have, however, investigated this relationship directly in colorectal tissue with conflicting results....

    Authors: Nasibeh Khodaverdi, Habib Zeighami, Ahmad Jalilvand, Fakhri Haghi and Negar Hesami
    Citation: BMC Cancer 2021 21:1353
    Content type: Research Published on:

  35. It is important to confirm CD30 expression in T-cell lymphoma cases, but immunohistochemical staining for CD30 is not commonly performed and no comparison has been done between the results of flow cytometry (F...

    Authors: Fumiyoshi Fujishima, Noriko Fukuhara, Hiroki Katsushima, Yasuhiro Nakamura, Hideo Harigae, Hironobu Sasano and Ryo Ichinohasama
    Citation: BMC Cancer 2021 21:1352
    Content type: Research Published on:

  36. Polygenic risk scores (PRS) could potentially improve breast cancer screening recommendations. Before a PRS can be considered for implementation, it needs rigorous evaluation, using performance measures that c...

    Authors: Maria Olsen, Krista Fischer, Patrick M. Bossuyt and Els Goetghebeur
    Citation: BMC Cancer 2021 21:1351
    Content type: Research article Published on:

  37. Patients with pathogenic sequence variants (PSVs) in BRCA1/BRCA2 are at high risk of developing ovarian cancer (OC). However, genetic testing for BRCA1/BRCA2 PSVs is still not a routine practice in the Middle Eas...

    Authors: Fathi Azribi, Ehab Abdou, Emad Dawoud, Mohamed Ashour, Amgad Kamal, Mohamed Al Sayed and Ikram Burney
    Citation: BMC Cancer 2021 21:1350
    Content type: Research Published on:

  38. Most breast cancer patients with non-metastatic disease receive adjuvant local or loco-regional radiotherapy. To be scheduled for irradiation may cause distress and fears that can lead to sleep disorders. Few ...

    Authors: Dirk Rades, Carlos A. Narvaez, Liesa Dziggel, Stefan Janssen, Denise Olbrich, Soeren Tvilsted and Troels W. Kjaer
    Citation: BMC Cancer 2021 21:1349
    Content type: Study protocol Published on:

  39. The ESR1 gene encodes Estrogen Receptor alpha (ERα), which plays a role in the tumourigenesis of breast cancer. A single nucleotide polymorphism (SNP) in intron 1 of this gene called ESR1 PvuII (rs2234693) has be...

    Authors: Ramadhan Karsono, Samuel J. Haryono, Bambang Karsono, Wirsma Arif Harahap, Yulia Pratiwi and Teguh Aryandono
    Citation: BMC Cancer 2021 21:1348
    Content type: Research article Published on:

  40. The accuracy of existing biomarkers for predicting the prognosis of hepatocellular carcinoma (HCC) is not satisfactory. It is necessary to explore biomarkers that can accurately predict the prognosis of HCC.

    Authors: Min Deng, Jia-Bao Lin, Rong-Ce Zhao, Shao-Hua Li, Wen-Ping Lin, Jing-Wen Zou, Wei Wei and Rong-Ping Guo
    Citation: BMC Cancer 2021 21:1347
    Content type: Research article Published on:

  41. Cranial irradiation represents one of the first line treatment proposed in skull base meningiomas. While cranial irradiation is associated with a high risk of secondary hypopituitarism, few studies focused on ...

    Authors: Perrine Raymond, Marc Klein, Thomas Cuny, Olivier Klein, Julia Salleron and Valérie Bernier-Chastagner
    Citation: BMC Cancer 2021 21:1346
    Content type: Research Published on:

  42. Osteosarcomas are one of the most common primary malignant tumors of bone. It primarily occurs in children and adolescents, with the second highest incidence among people over 50 years old. Although there were...

    Authors: Ruixuan Liu, Yuhang Hu, Tianyi Liu and Yansong Wang
    Citation: BMC Cancer 2021 21:1345
    Content type: Research Published on:

  43. In this study, we tried to access the efficacy and safety of oxaliplatin plus S-1 with intraperitoneal paclitaxel (PTX) for the treatment of Chinese advanced gastric cancer with peritoneal metastases.

    Authors: Min Shi, Zhongyin Yang, Sheng Lu, Wentao Liu, Zhentian Ni, Xuexin Yao, Zichen Hua, Runhua Feng, Yanan Zheng, Zhenqiang Wang, Birendra Kumar Sah, Mingmin Chen, Zhenglun Zhu, Changyu He, Chen Li, Jun Zhang…
    Citation: BMC Cancer 2021 21:1344
    Content type: Research article Published on:

  44. Chemotherapy is frequently used in cancer treatment; however, it may cause adverse events, which must be managed. Reactive oxygen species (ROS) have been reported to be involved in the induction of intestinal ...

    Authors: Junya Yoneda, Sachiko Nishikawa and Shigekazu Kurihara
    Citation: BMC Cancer 2021 21:1343
    Content type: Research Published on:

  45. Chromatin state provides a clear decipherable blueprint for maintenance of transcriptional patterns, exemplifying a mitotically stable form of cellular programming in dividing cells. In this regard, genomic st...

    Authors: Garrett L. Ruff, Kristin E. Murphy, Zachary R. Smith, Paula M. Vertino and Patrick J. Murphy
    Citation: BMC Cancer 2021 21:1342
    Content type: Research article Published on:

  46. The debate continues among medical professionals regarding the frequency, starting age, and stopping age for mammography screening. Some experts suggest tailoring recommendations based on individuals’ personal...

    Authors: Hannah Lui Park, Jenny Chang, Vikram Haridass, Sophia S. Wang, Argyrios Ziogas and Hoda Anton-Culver
    Citation: BMC Cancer 2021 21:1341
    Content type: Research Published on:

  48. Malignant melanoma is an aggressive skin cancer and a tumor of melanocytic origin. Recent studies have suggested that long non-coding RNAs (lncRNAs) play crucial regulatory roles in multiple malignancies, incl...

    Authors: Yingna Zheng, Wu Zhou, Min Li, Ruixue Xu, Shuai Zhang, Ying Liu and Ying Cen
    Citation: BMC Cancer 2021 21:1339
    Content type: Research article Published on:

  50. Microvascular invasion (MVI) adversely affects postoperative long-term survival outcomes in patients with hepatocellular carcinoma (HCC). There is no study addressing genetic changes in HCC patients with MVI. ...

    Authors: Jin Wang, Zhi-Wen Ding, Kuang Chen, Yan-Zhe Liu, Nan Li and Ming-Gen Hu
    Citation: BMC Cancer 2021 21:1337
    Content type: Research Published on:

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