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  1. Esophageal squamous cell carcinoma (ESCC) is a major cause of cancer morbidity and mortality in Eastern Africa. The majority of patients with ESCC in Eastern Africa present with advanced disease at the time of...

    Authors: Geoffrey C. Buckle, Alita Mrema, Michael Mwachiro, Yona Ringo, Msiba Selekwa, Gift Mulima, Fatma F. Some, Blandina T. Mmbaga, Gita N. Mody, Li Zhang, Alan Paciorek, Larry Akoko, Paul Ayuo, Stephen Burgert, Elizabeth Bukusi, Anthony Charles…
    Citation: BMC Cancer 2022 22:82
    Content type: Study protocol Published on:

  2. Long non-coding RNA (LncRNA) HOTAIR was amplified and overexpressed in many human carcinomas, which could serve as a useful target for cancer early detection and treatment. The 99mTc radiolabeled antisense oligon...

    Authors: Jiongyu Ren, Xiyuan Zhang, Jiang Cao, Jiali Tian, Jin Luo, Yaping Yu, Fengkui Wang and Qian Zhao
    Citation: BMC Cancer 2022 22:79
    Content type: Research Published on:

  3. Sarcopenia is defined by a loss of muscle strength associated to a decrease in skeletal muscle mass. Ageing greatly contributes to sarcopenia as may many other factors such as cancer or androgen deprivation th...

    Authors: Anne-Laure Couderc, Patrick Villani, Julie Berbis, Emilie Nouguerède, Dominique Rey, Dominique Rossi, Éric Lechevallier, Delphine Badinand, Cyrille Bastide, Gilles Karsenty, Romain Boissier, Kahena Amichi and Xavier Muracciole
    Citation: BMC Cancer 2022 22:78
    Content type: Study protocol Published on:

  5. The impact of hepatic resection for liver metastases (LM) on the survival of pediatric patients with Wilms’ tumor (WT) is unclear. So far, there is a lack of studies investigating the best suited treatment for...

    Authors: Juri Fuchs, Anastasia Murtha-Lemekhova, Markus Kessler, Patrick Günther and Katrin Hoffmann
    Citation: BMC Cancer 2022 22:76
    Content type: Research Published on:

  6. Cancer patients experience increased risk of death from accident and suicide. Cognitive impairment induced by cancer-related inflammation and stress-related psychiatric symptoms may be underlying mechanisms. W...

    Authors: Qing Shen, Arvid Sjölander, Erica K. Sloan, Adam K. Walker, Katja Fall, Unnur Valdimarsdottir, Pär Sparén, Karin E. Smedby and Fang Fang
    Citation: BMC Cancer 2022 22:75
    Content type: Research Published on:

  8. Microsatellite instability (MSI) is a key marker for predicting the response of immune checkpoint inhibitors (ICIs) and for screening Lynch syndrome (LS).

    Authors: Hiroyuki Matsubayashi, Satomi Higashigawa, Yoshimi Kiyozumi, Takuma Oishi, Keiko Sasaki, Hirotoshi Ishiwatari, Kenichiro Imai, Kinichi Hotta, Yohei Yabuuchi, Kazuma Ishikawa, Tatsunori Satoh, Hiroyuki Ono, Akiko Todaka, Takeshi Kawakami, Hiromichi Shirasu, Hirofumi Yasui…
    Citation: BMC Cancer 2022 22:73
    Content type: Research Published on:

  9. Transcripts with alternative 5′-untranslated regions (UTRs) result from the activity of alternative promoters and they can determine gene expression by influencing its stability and translational efficiency, t...

    Authors: Tamara Babic, Sandra Dragicevic, Marko Miladinov, Zoran Krivokapic and Aleksandra Nikolic
    Citation: BMC Cancer 2022 22:72
    Content type: Research Published on:

  10. As segmentectomy had become commonly used for Non-Small Cell Lung Cancer (NSCLC) treatment, which had the advantages of radical operation, however, it remains controversial owing to procedural complexity and r...

    Authors: Yaodong Zhou, Tao Yu, Yixin Zhang, Liqiang Qian and Qing Xia
    Citation: BMC Cancer 2022 22:71
    Content type: Research Published on:

  11. It is unknown whether and to what degree trials submitted to the US FDA to support drug approval adhere to NCCN guideline-recommended care in their baseline and surveillance CNS imaging protocols.

    Authors: John Sharp and Vinay Prasad
    Citation: BMC Cancer 2022 22:70
    Content type: Research Published on:

  12. The Predicting Risk of Cancer at Screening (PROCAS) study provided women who were eligible for breast cancer screening in Greater Manchester (United Kingdom) with their 10-year risk of breast cancer, i.e., low...

    Authors: Linda Rainey, Daniëlle van der Waal, Louise S. Donnelly, Jake Southworth, David P. French, D. Gareth Evans and Mireille J. M. Broeders
    Citation: BMC Cancer 2022 22:69
    Content type: Research Published on:

  14. Neoadjuvant chemoradiation therapy (nCRT) is the standard treatment modality in locally advanced rectal cancer (LARC). Since response to radiotherapy (RT) is dose dependent in rectal cancer, dose escalation ma...

    Authors: Giuditta Chiloiro, Davide Cusumano, Luca Boldrini, Angela Romano, Lorenzo Placidi, Matteo Nardini, Elisa Meldolesi, Brunella Barbaro, Claudio Coco, Antonio Crucitti, Roberto Persiani, Lucio Petruzziello, Riccardo Ricci, Lisa Salvatore, Luigi Sofo, Sergio Alfieri…
    Citation: BMC Cancer 2022 22:67
    Content type: Study protocol Published on:

  15. To identify and describe the breast cancer–specific health-related quality of life (HRQoL) instruments with evidence of validation in the breast cancer population for potential use in patients treated for brea...

    Authors: Maribel Salas, Margaret Mordin, Colleen Castro, Zahidul Islam, Nora Tu and Michelle D. Hackshaw
    Citation: BMC Cancer 2022 22:66
    Content type: Research article Published on:

  17. Eribulin or capecitabine monotherapy is the next cytotoxic chemotherapy option for patients with metastatic or recurrent breast cancer who have previously received an anthracycline or a taxane. However, it is ...

    Authors: Shigemasa Takamizawa, Tatsunori Shimoi, Natsuko Satomi-Tsushita, Shu Yazaki, Toshihiro Okuya, Yuki Kojima, Hitomi Sumiyoshi-Okuma, Tadaaki Nishikawa, Maki Tanioka, Kazuki Sudo, Emi Noguchi and Kan Yonemori
    Citation: BMC Cancer 2022 22:64
    Content type: Research Published on:

  18. Inflammation-scores based on general inflammation markers are suggested as prognostic markers of overall survival (OS) in lung cancer. However, whether these inflammation-scores improves the prognostication pe...

    Authors: Anne Winther-Larsen, Ninna Aggerholm-Pedersen and Birgitte Sandfeld-Paulsen
    Citation: BMC Cancer 2022 22:63
    Content type: Research Published on:

  19. The immune system recognizes and destroys cancer cells. However, cancer cells develop mechanisms to avoid detection by expressing cell surface proteins. Specific tumour cell surface proteins (e.g. HLA-G, PD-L1...

    Authors: Astrid Louise Bjørn Bennedsen, Luyi Cai, Rune Petring Hasselager, Aysun Avci Özcan, Khadra Bashir Mohamed, Jens Ole Eriksen, Susanne Eiholm, Michael Bzorek, Anne-Marie Kanstrup Fiehn, Thomas Vauvert F. Hviid and Ismail Gögenur
    Citation: BMC Cancer 2022 22:62
    Content type: Research Published on:

  21. High-dose methotrexate (HD-MTX) has broad use in the treatment of central nervous system (CNS) malignancies but confers significant toxicity without inpatient hydration and monitoring. Glucarpidase is a bacter...

    Authors: Lauren R. Schaff, Mina Lobbous, Dean Carlow, Ryan Schofield, Igor T. Gavrilovic, Alexandra M. Miller, Jacqueline B. Stone, Anna F. Piotrowski, Ugur Sener, Anna Skakodub, Edward P. Acosta, Kevin J. Ryan, Ingo K. Mellinghoff, Lisa M. DeAngelis, Louis B. Nabors and Christian Grommes
    Citation: BMC Cancer 2022 22:60
    Content type: Research Published on:

  22. Administration of poly (ADP-ribose) polymerase (PARP) inhibitors after achieving a response to platinum-containing drugs significantly prolonged relapse-free survival compared to placebo administration. PARP i...

    Authors: Masakazu Sato, Sho Sato, Daisuke Shintani, Mieko Hanaoka, Aiko Ogasawara, Maiko Miwa, Akira Yabuno, Akira Kurosaki, Hiroyuki Yoshida, Keiichi Fujiwara and Kosei Hasegawa
    Citation: BMC Cancer 2022 22:59
    Content type: Research Published on:

  23. The importance of assessing and monitoring the health status of a population has grown in the last decades. Consistent and high quality data on the morbidity and mortality impact of a disease represent the key...

    Authors: Vanessa Gorasso, Geert Silversmit, Marc Arbyn, Astrid Cornez, Robby De Pauw, Delphine De Smedt, Ian Grant, Grant M. A. Wyper, Brecht Devleesschauwer and Niko Speybroeck
    Citation: BMC Cancer 2022 22:58
    Content type: Research Published on:

  24. Although many psychological factors have been associated with health-related quality of life (HRQoL), the mediator role of resilience between psychological predictors (i.e., coping styles and perceived social ...

    Authors: Kaina Zhou, Fan Ning, Wen Wang and Xiaomei Li
    Citation: BMC Cancer 2022 22:57
    Content type: Research Published on:

  25. There is increasing evidence that combination therapy with nanoparticle albumin-bound paclitaxel (nab-paclitaxel) and programmed cell death protein 1 (PD-1) inhibitor is safe and efficacious in treating many t...

    Authors: Zhichao Tian, Shuping Dong, Yang Yang, Shilei Gao, Yonghao Yang, Jinpo Yang, Peng Zhang, Xin Wang and Weitao Yao
    Citation: BMC Cancer 2022 22:56
    Content type: Research Published on:

  26. Vascular endothelial growth factor (VEGF) plays a role in the tumor microenvironment. Sorafenib, which inhibits the VEGF pathway, has an immune-modulation function but lacks substantial clinical data. This stu...

    Authors: San-Chi Chen, Yi-Hsiang Huang, Ming-Huang Chen, Yi-Ping Hung, Rheun-Chuan Lee, Yu-Yun Shao and Yee Chao
    Citation: BMC Cancer 2022 22:55
    Content type: Research Published on:

  27. Interleukin (IL)-17 family is a group of six cytokines that plays a central role in inflammatory processes and participates in cancer progression. Interleukin-17A has been shown to have mainly a protumorigenic...

    Authors: Tiina Mikkola, Rabeia Almahmoudi, Tuula Salo and Ahmed Al-Samadi
    Citation: BMC Cancer 2022 22:54
    Content type: Research Published on:

  28. Dysphagia is prevalent in oesophageal cancer with significant clinical and psychosocial complications. The purpose of this study was i) to examine the impact of exercise-based dysphagia rehabilitation on clini...

    Authors: Anna Gillman, Michelle Hayes, Greg Sheaf, Margaret Walshe, John V. Reynolds and Julie Regan
    Citation: BMC Cancer 2022 22:53
    Content type: Research article Published on:

  30. Safety and efficacy of immune checkpoint inhibitors in advanced gastric or gastroesophageal junction (GEJ) cancer could be demonstrated in predominantly Asian cohorts, whereas data in Western patients outside ...

    Authors: Verena Schlintl, Florian Huemer, Gabriel Rinnerthaler, Thomas Melchardt, Thomas Winder, Patrick Reimann, Jakob Riedl, Arno Amann, Wolfgang Eisterer, Franz Romeder, Gudrun Piringer, Aysegül Ilhan-Mutlu, Ewald Wöll, Richard Greil and Lukas Weiss
    Citation: BMC Cancer 2022 22:51
    Content type: Research article Published on:

  31. Breast cancer is the most common cancer, and the leading cause of cancer-related deaths, among females world-wide. Recent research suggests that extracellular vesicles (EVs) play a major role in the developmen...

    Authors: Karin Ekström, Rossella Crescitelli, Hafsteinn Ingi Pétursson, Junko Johansson, Cecilia Lässer and Roger Olofsson Bagge
    Citation: BMC Cancer 2022 22:50
    Content type: Research Published on:

  32. Colorectal cancer (CRC) represents a common malignancy in gastrointestinal tract. Iodine-125 (125I) seed implantation is an emerging treatment technology for unresectable tumors. This study investigated the mecha...

    Authors: Fenghai Ren, Baojun Li, Chao Wang, Yanbo Wang and Binbin Cui
    Citation: BMC Cancer 2022 22:49
    Content type: Research Published on:

  33. The incidence rate of colorectal cancer (CRC) is increasing among patients below 50 years of age. The reason for this is unclear, but could have to do with the fact that indicative variables, such as tumour lo...

    Authors: Benyamin Hoseini, Zahra Rahmatinejad, Ladan Goshayeshi, Robert Bergquist, Amin Golabpour, Kamran Ghaffarzadegan, Fatemeh Rahmatinejad, Reza Darrudi and Saeid Eslami
    Citation: BMC Cancer 2022 22:48
    Content type: Research Published on:

  34. Pharmacogenetic (PGx) testing for germline variants in the DPYD and UGT1A1 genes can be used to guide fluoropyrimidine and irinotecan dosing, respectively. Despite the known association between PGx variants and c...

    Authors: Kelsey S. Lau-Min, Lisa A. Varughese, Maria N. Nelson, Christine Cambareri, Nandi J. Reddy, Randall A. Oyer, Ursina R. Teitelbaum and Sony Tuteja
    Citation: BMC Cancer 2022 22:47
    Content type: Research Published on:

  35. Immune checkpoint inhibitors (ICIs) are currently one of the most promising therapy options in the field of oncology. Although the first pivotal ICI trial results were published in 2011, few biomarkers exist t...

    Authors: Michael Wessolly, Susann Stephan-Falkenau, Anna Streubel, Marcel Wiesweg, Sabrina Borchert, Elena Mairinger, Jens Kollmeier, Henning Reis, Torsten Bauer, Kurt Werner Schmid, Thomas Mairinger, Martin Schuler and Fabian D. Mairinger
    Citation: BMC Cancer 2022 22:46
    Content type: Research Published on:

  36. Adult sporadic Burkitt lymphoma (BL) is a rare but highly aggressive subtype of lymphoma which lacks its own unique prognostic model. Systemic inflammatory biomarkers have been confirmed as prognostic markers ...

    Authors: Mei-ting Chen, Fei Pan, Yung-chang Chen, Wei Zhang, Hui-juan Lv, Zhao Wang, Huang-ming Hong, Xiao-jie Fang, Ya-wen Wang, Tao Pan, Li-qun Zou, Hong-qiang Guo, Ke Xie, Li-min Chen, Xiao-qian Li, Yu-yi Yao…
    Citation: BMC Cancer 2022 22:45
    Content type: Research Published on:

  37. Peroxisomes are pivotal metabolic organelles that exist in almost all eukaryote cells. A reduction in numbers and enzymatic activities of peroxisomes was found in colon adenocarcinomas. However, the role of pe...

    Authors: Jinwen Yin, Hao Wang, Yuntian Hong, Anli Ren, Haizhou Wang, Lan Liu and Qiu Zhao
    Citation: BMC Cancer 2022 22:44
    Content type: Research Published on:

  38. Malnutrition is common in cancer patients. The NUTRISCORE is a newly developed cancer-specific nutritional screening tool and was validated by comparison with the Patient-Generated Subjective Global Assessment...

    Authors: Junren Kang, Hailong Li, Xiaodong Shi, Enling Ma and Wei Chen
    Citation: BMC Cancer 2022 22:43
    Content type: Research article Published on:

  39. The aim of the study was to investigate the risk of human papillomavirus (HPV) genotyping particularly vaccine genotypes and multiple infections for cervical precancer and cancer, which might contribute to dev...

    Authors: Fangbin Song, Peisha Yan, Xia Huang, Chun Wang, Hui Du, Xinfeng Qu and Ruifang Wu
    Citation: BMC Cancer 2022 22:42
    Content type: Research Published on:

  40. Nowadays, evaluation of the efficacy and the duration of treatment, in context of monitoring patients with solid tumors, is based on the RECIST methodology. With these criteria, resistance and/or insensitivity...

    Authors: Sébastien Vachenc, Jessica Gobbo, Sarah El Moujarrebe, Isabelle Desmoulins, Marine Gilabert, Michelle Beau-Faller, Emmanuel Mitry, Nicolas Girard, Aurélie Bertaut, Nelson Dusetti, Juan L. Iovanna, Rahima Yousfi, Fabien Pierrat, Roman Bruno, Adèle Cueff, Romain Boidot…
    Citation: BMC Cancer 2022 22:41
    Content type: Study protocol Published on:

  41. The microvessels area (MVA), derived from microvascular proliferation, is a biomarker useful for high-grade glioma classification. Nevertheless, its measurement is costly, labor-intense, and invasive. Finding ...

    Authors: María del Mar Álvarez-Torres, Elies Fuster-García, Javier Juan-Albarracín, Gaspar Reynés, Fernando Aparici-Robles, Jaime Ferrer-Lozano and Juan Miguel García-Gómez
    Citation: BMC Cancer 2022 22:40
    Content type: Research article Published on:

  42. Lactic acid produced by tumors has been shown to overcome immune surveillance, by suppressing the activation and function of T cells in the tumor microenvironment. The strategies employed to impair tumor cell ...

    Authors: Hosein Rostamian, Mohammad Khakpoor-Koosheh, Leila Jafarzadeh, Elham Masoumi, Keyvan Fallah-Mehrjardi, Mohammad Javad Tavassolifar, John M. Pawelek, Hamid Reza Mirzaei and Jamshid Hadjati
    Citation: BMC Cancer 2022 22:39
    Content type: Research Published on:

  43. Melanoma-intrinsic activated β-catenin pathway, the product of the catenin beta 1 (CTNNB1) gene, has been associated with low/absent tumor-infiltrating lymphocytes, accelerated tumor growth, metastases developmen...

    Authors: Georgia Sofia Karachaliou, Rached Alkallas, Sarah B. Carroll, Chongshan Caressi, Danny Zakria, Nirali M. Patel, Dimitri G. Trembath, Jennifer A. Ezzell, Guillaume J. Pegna, Paul B. Googe, Jonathan P. Galeotti, Fatih Ayvali, Frances A. Collichio, Carrie B. Lee, David W. Ollila, Margaret L. Gulley…
    Citation: BMC Cancer 2022 22:38
    Content type: Research Published on:

  45. Trastuzumab and fulvestrant combination therapy is one of the treatment options for patients with hormone receptor- and human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer; howeve...

    Authors: Yukinori Ozaki, Yosuke Aoyama, Jun Masuda, Lina Inagaki, Saori Kawai, Tomoko Shibayama, Tetsuyo Maeda, Mami Kurata, Kazuyo Yoshida, Sumito Saeki, Mari Hosonaga, Ippei Fukada, Fumikata Hara, Takayuki Kobayashi, Kokoro Kobayashi, Satoshi Miyake…
    Citation: BMC Cancer 2022 22:36
    Content type: Research Published on:

  46. No standard radiotherapy regimens have been established for the treatment of de novo metastatic nasopharyngeal carcinoma (mNPC) with bone-only metastasis. The current study aimed to investigate the efficacy of...

    Authors: Cheng Lin, Sheng Lin, Lili Zhu, Shaojun Lin, Jianji Pan and Yun Xu
    Citation: BMC Cancer 2022 22:35
    Content type: Research Published on:

  48. At present, no predictive factor has been validated for the early efficacy of neoadjuvant chemotherapy (NACT) in osteosarcoma. The purpose of this study was to investigate the significance of the neutrophil-to...

    Authors: Haijun Tang, Dehuai Liu, Jili Lu, Juliang He, Shuyu Ji, Shijie Liao, Qingjun Wei, Shenglin Lu and Yun Liu
    Citation: BMC Cancer 2022 22:33
    Content type: Research Published on:

  50. Paratesticular leiomyosarcoma (LMS) is a rare tumor. Conventionally, tumor resection by high inguinal orchiectomy is performed as the preferred treatment approach for paratesticular sarcoma. On the other hand,...

    Authors: Rei Kamitani, Kazuhiro Matsumoto, Toshikazu Takeda, Ryuichi Mizuno and Mototsugu Oya
    Citation: BMC Cancer 2022 22:15
    Content type: Research Published on:

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