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  2. The induction of ferroptosis and pyroptosis has been highlighted as a novel approach to decide cancer cell fate. However, few studies have systematically explored the role of combining these two novel cell dea...

    Authors: Lijun Xu, Qing Zheng and Wenwen Liu
    Citation: BMC Cancer 2022 22:229
    Content type: Research Published on:

  4. The oncogenic drivers of triple-negative breast cancer (TNBC), which is characterized by worst prognosis compared with other subtypes, are poorly understood. Although next-generation sequencing technology has ...

    Authors: Xi Zhang, Xin Mu, Ou Huang, Zhitang Wang, Jialin Chen, Debo Chen and Gen Wang
    Citation: BMC Cancer 2022 22:226
    Content type: Research Published on:

  5. The development of lung adenocarcinoma (LUAD) involves the interactions between cell proliferation and death. Autophagy-dependent ferroptosis, a distinctive cell death process, was implicated in a multitude of...

    Authors: Huikai Miao, Qiannan Ren, Hongmu Li, Mingyue Zeng, Dongni Chen, Chunmei Xu, Youfang Chen and Zhesheng Wen
    Citation: BMC Cancer 2022 22:225
    Content type: Research Published on:

  6. The goal of this study was to evaluate efficacy and safety of 90Y radioembolization for neuroendocrine liver metastases (NELM) in a multicenter registry.

    Authors: Thomas Y. Wong, Kevin S. Zhang, Ripal T. Gandhi, Zachary S. Collins, Ryan O’Hara, Eric A. Wang, Kirubahara Vaheesan, Lea Matsuoka, Daniel Y. Sze, Andrew S. Kennedy and Daniel B. Brown
    Citation: BMC Cancer 2022 22:224
    Content type: Research Published on:

  8. Rectal Cancer is a common malignancy. The current treatment approach for patients with locally advanced rectal cancer involves neoadjuvant chemoradiotherapy followed by surgical resection of the rectum. The re...

    Authors: Sina Vatandoust, David Wattchow, Luigi Sposato, Michael Z Michael, John Leung, Kirsten Gormly, Gang Chen, Erin L. Symonds, Jeanne Tie, Lito Electra Papanicolas, Susan Woods, Val Gebski, Kelly Mead, Aleksandra Kuruni and Christos S. Karapetis
    Citation: BMC Cancer 2022 22:222
    Content type: Study protocol Published on:

  9. Hepatocellular carcinoma (HCC) has high incidence and mortality worldwide. Local ablation using radiofrequency ablation (RFA) or microwave ablation (MWA) is potentially curative for early-stage HCC with outcom...

    Authors: Mohamed Abdulwahab Mohamed Ali, William Scott Harmsen, Khairy Hammam Morsy, Ghada Moustapha Kamal Galal, Terry M. Therneau and Lewis Rowland Roberts
    Citation: BMC Cancer 2022 22:221
    Content type: Research Published on:

  10. Cancer patient pathways (CPPs) were implemented in Norway to reduce unnecessary waiting times, regional variations, and to increase the predictability of cancer care for the patients. This study aimed to deter...

    Authors: Yngvar Nilssen, Odd Terje Brustugun, Morten Tandberg Eriksen, Marianne G. Guren, Erik Skaaheim Haug, Bjørn Naume, Ellen Schlichting and Bjørn Møller
    Citation: BMC Cancer 2022 22:220
    Content type: Research Published on:

  11. Annexin A10 expression influences the prognosis of several gastrointestinal cancers. We explored the association of annexin A10 expression with the overall survival (OS) of patients who underwent curative surg...

    Authors: Yu-Yun Shao, Hung-Yang Kuo, Yung-Ming Jeng, Yao-Ming Wu, Hsiu-Po Wang, Chiun Hsu, Chih-Hung Hsu, Hey-Chi Hsu, Ann-Lii Cheng and Zhong-Zhe Lin
    Citation: BMC Cancer 2022 22:219
    Content type: Research Published on:

  12. Malignant ascites often causes discomfort in advanced cancer patients. Paracentesis is the most common treatment modality, but it requires frequently repeated treatment. Cell-free and concentrated ascites rein...

    Authors: Naosuke Yokomichi, Kengo Imai, Masaki Sakamoto, Masashi Horiki, Toshihiro Yamauchi, Satoru Miwa, Satoshi Inoue, Yu Uneno, Hidekazu Suzuki, Toru Wada, Yuri Ichikawa and Tatsuya Morita
    Citation: BMC Cancer 2022 22:218
    Content type: Research Published on:

  13. Fear of cancer recurrence (FCR) has been addressed as a cause of emotional distress among breast cancer survivors (BCSs). This study aimed to systematically review the evidence on randomized controlled trials ...

    Authors: So-Young Park and Jung-Won Lim
    Citation: BMC Cancer 2022 22:217
    Content type: Research Published on:

  15. Low-grade glioma (LGG) is susceptible to ferroptosis, which is involved in TMZ resistance. Ferroptosis induction can enhance the sensitivity to TMZ and synergistically kill glioma cells. T cell-promoted tumor ...

    Authors: Yanhua Mou, Lu Zhang, Zhantao Liu and Xiujun Song
    Citation: BMC Cancer 2022 22:215
    Content type: Research Published on:

  16. Bladder cancer (BC) is one of the most frequent cancer in the world, and its incidence is rising worldwide, especially in developed countries. Urine metabolomics is a powerful approach to discover potential bi...

    Authors: Rui Wang, Huaixing Kang, Xu Zhang, Qing Nie, Hongling Wang, Chaojun Wang and Shujun Zhou
    Citation: BMC Cancer 2022 22:214
    Content type: Research Published on:

  17. Glioma cells are characterized by high migration ability, resulting in aggressive growth of the tumors and poor prognosis of patients. It has been reported that the stress-induced hormone norepinephrine (NE) c...

    Authors: Xue Wang, Ying Wang, Fang Xie, Zi-Tian Song, Zi-Qian Zhang, Yun Zhao, Shi-Da Wang, Hui Hu, Yan-Shu Zhang and Ling-Jia Qian
    Citation: BMC Cancer 2022 22:213
    Content type: Research Published on:

  18. Peri-operative chemo-radiotherapyplayed important rolein locally advanced gastric cancer. Whether preoperative strategy can improve the long-term prognosis compared with postoperative treatment is unclear. The...

    Authors: Ning Li, Xiaoyong Xiang, Dongbin Zhao, Xin Wang, Yuan Tang, Yihebali Chi, Lin Yang, Liming Jiang, Jun Jiang, Jinming Shi, Wenyang Liu, Hui Fang, Yu Tang, Bo Chen, Ningning Lu, Hao Jing…
    Citation: BMC Cancer 2022 22:212
    Content type: Research Published on:

  19. Immunotherapy is a novel hotspot for the treatment of pancreatic adenocarcinoma (PAAD). However, potential biomarkers which could identify the inflamed tumor microenvironment (TME) are urgently required.

    Authors: Shuping Si, Lei Wang, Hui Cao, Yuhua Xu and Qiang Zhan
    Citation: BMC Cancer 2022 22:211
    Content type: Research Published on:

  20. We collected information on patients with rectal adenocarcinoma in the United States from the Surveillance, Epidemiology, and EndResults (SEER) database. We used this information to establish a model that comb...

    Authors: Haohui Yu, Tao Huang, Bin Feng and Jun Lyu
    Citation: BMC Cancer 2022 22:210
    Content type: Research Published on:

  21. The Kaiser Permanente Research Bank (KPRB) is collecting biospecimens and surveys linked to electronic health records (EHR) from approximately 400,000 adult KP members. Within the KPRB, we developed a Cancer C...

    Authors: Heather Spencer Feigelson, Christina L. Clarke, Stephen K. Van Den Eeden, Sheila Weinmann, Andrea N. Burnett-Hartman, Sarah Rowell, Shauna Goldberg Scott, Larissa L. White, Monica Ter-Minassian, Stacey A. A. Honda, Deborah R. Young, Aruna Kamineni, Terrence Chinn, Alexander Lituev, Alan Bauck and Elizabeth A. McGlynn
    Citation: BMC Cancer 2022 22:209
    Content type: Research Published on:

  22. Elucidation of specific and recurrent/founder pathogenic variants (PVs) in BRCA (BRCA1 and BRCA2) genes can make the genetic testing, for breast cancer (BC) and/or ovarian cancer (OC), affordable for developing n...

    Authors: Oubaida ElBiad, Abdelilah Laraqui, Fatima El Boukhrissi, Chaimaa Mounjid, Maryame Lamsisi, Tahar Bajjou, Hicham Elannaz, Amine Idriss Lahlou, Jaouad Kouach, Khadija Benchekroune, Mohammed Oukabli, Hafsa Chahdi, Moulay Mustapha Ennaji, Rachid Tanz, Yassir Sbitti, Mohammed Ichou…
    Citation: BMC Cancer 2022 22:208
    Content type: Research Published on:

  23. The purpose of the present study was to investigate risk factors for esophageal fistula (EF) in patients with recurrent esophageal cancer receiving re-radiotherapy with or without chemotherapy.

    Authors: Xinran Wang, Bing Hu, Jinhu Chen, Feihong Xie, Dan Han, Qian Zhao, Hongfu Sun, Chengrui Fu, Chengxin Liu, Zhongtang Wang, Haiqun Lin and Wei Huang
    Citation: BMC Cancer 2022 22:207
    Content type: Research Published on:

  24. The aims of this study were to investigate the long-term outcomes of primary versus postoperative Gamma Knife radiosurgery (GKRS) for benign meningiomas.

    Authors: Junyi Fu, Jiamin Zeng, Minyi Huang, Shunyao Liang, Yong He, Longchang Xie, Yinhui Deng and Jinxiu Yu
    Citation: BMC Cancer 2022 22:206
    Content type: Research Published on:

  25. Cancer-associated fibroblasts (CAFs) are an important component of the tumour microenvironment. Recent studies revealed CAFs are heterogeneous and CAF subset(s) that suppress cancer progression (cancer-restrai...

    Authors: Yasuyuki Mizutani, Tadashi Iida, Eizaburo Ohno, Takuya Ishikawa, Fumie Kinoshita, Yachiyo Kuwatsuka, Miwa Imai, Shinobu Shimizu, Toshihisa Tsuruta, Atsushi Enomoto, Hiroki Kawashima and Mitsuhiro Fujishiro
    Citation: BMC Cancer 2022 22:205
    Content type: Study protocol Published on:

  26. Lung cancer is a leading cause of cancer-related deaths in Uganda. In this study, we aimed to describe the baseline characteristics and survival of patients with lung cancer at the Uganda Cancer Institute (UCI).

    Authors: Naghib Bogere, Felix Bongomin, Andrew Katende, Blair Andrew Omaido, Elizabeth Namukwaya, Harriet Mayanja-Kizza and Victoria Walusansa
    Citation: BMC Cancer 2022 22:204
    Content type: Research Published on:

  27. The aim of this systematic review was to evaluate the evidence and clinical outcomes of screening interventions and implementation trials in sub-Saharan Africa (SSA) and also appraise some ethical issues relat...

    Authors: Yehoda M. Martei, Bege Dauda and Verna Vanderpuye
    Citation: BMC Cancer 2022 22:203
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2022 22:306

  28. To evaluate the impact of different adjuvant therapy on IB1 and IIA1 stage cervical squamous cell cancer patients with lymphovascular space invasion. It also aimed to analyze the relationship between lymphovas...

    Authors: Hao Zhang, Rao Yu, Lan Zhang, Rong Wang and Lin Xiao
    Citation: BMC Cancer 2022 22:202
    Content type: Research Published on:

  29. Acute promyelocytic leukemia (APL) is considered a hematologic emergency due to high risk of bleeding and fatal hemorrhages being a major cause of death. Despite lower death rates reported from clinical trials...

    Authors: Jan-Niklas Eckardt, Tim Schmittmann, Sebastian Riechert, Michael Kramer, Anas Shekh Sulaiman, Katja Sockel, Frank Kroschinsky, Johannes Schetelig, Lisa Wagenführ, Ulrich Schuler, Uwe Platzbecker, Christian Thiede, Friedrich Stölzel, Christoph Röllig, Martin Bornhäuser, Karsten Wendt…
    Citation: BMC Cancer 2022 22:201
    Content type: Research Published on:

  31. Breast cancer is a global health issue and a leading cause of death among women. Early detection through increased awareness and knowledge on breast cancer and breast cancer screening is thus crucial. The aim ...

    Authors: Rumpa Sarker, Md. Saiful Islam, Mst. Sabrina Moonajilin, Mahmudur Rahman, Hailay Abrha Gesesew and Paul R. Ward
    Citation: BMC Cancer 2022 22:199
    Content type: Research Published on:

  32. The clinical features, survival outcomes and patterns of treatment failure of advanced non-small cell lung cancer (NSCLC) patients harboring distinct subtypes of EGFR mutations and receiving first-line EGFR ty...

    Authors: Ya Zeng, Tiantian Guo, Yue Zhou, Yang Zhao, Li Chu, Xiao Chu, Xi Yang, Jianjiao Ni and Zhengfei Zhu
    Citation: BMC Cancer 2022 22:198
    Content type: Research Published on:

  34. Several investigations have reported diverse roles of long non-coding RNA (lncRNA) in biological processes, tumor development, and progression of colorectal cancer (CRC). In this study, we investigated the lnc...

    Authors: Arash Poursheikhani, Mohammad Reza Abbaszadegan and Mohammad Amin Kerachian
    Citation: BMC Cancer 2022 22:196
    Content type: Research article Published on:

  35. In selected patients with bladder cancer, partial cystectomy is an alternative treatment for bladder preservation with fair oncologic result. During partial cystectomy, tumor margin demarcation is difficult. V...

    Authors: Kang Sup Kim, Sang Hoon Kim, Hyuk Jin Cho, Hong Jin Sur and Yong Sun Choi
    Citation: BMC Cancer 2022 22:195
    Content type: Research Published on:

  36. Authors: Lei Ye, Lei Hu, Weiyong Liu, Yuanyuan Luo, Zhe Li, Zuopeng Ding, Chunmei Hu, Lin Wang, Yajuan Zhu, Le Liu, Xiaopeng Ma, Yuan Kong and Liangliang Huang
    Citation: BMC Cancer 2022 22:194
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2021 21:1250

  37. Lung cancer is among the major diseases threatening human health. Although the immune response plays an important role in tumor development, its exact mechanisms are unclear.

    Authors: Shaodi Wen, Weiwei Peng, Yuzhong Chen, Xiaoyue Du, Jingwei Xia, Bo Shen and Guoren Zhou
    Citation: BMC Cancer 2022 22:193
    Content type: Research Published on:

  38. Cervical cancer is frequently detected gynecological cancer all over the world. This study was designed to develop a prognostic signature for an effective prediction of cervical cancer prognosis.

    Authors: Wenxin Liu, Qiuying Jiang, Chao Sun, ShiHao Liu, Zhikun Zhao and Dongfang Wu
    Citation: BMC Cancer 2022 22:192
    Content type: Research Published on:

  39. The malignant pleural mesothelioma (MPM) response rate to chemotherapy is low. The identification of imaging biomarkers that could help guide the most effective therapy approach for individual patients is high...

    Authors: Martina Vivoda Tomšič, Peter Korošec, Viljem Kovač, Sotirios Bisdas and Katarina Šurlan Popovič
    Citation: BMC Cancer 2022 22:191
    Content type: Research article Published on:

  40. Primary central nervous system lymphoma (PCNSL) is a specific subtype of non-Hodgkin lymphoma that is highly invasive and confined to the central nervous system (CNS). The vast majority of PCNSLs are diffuse l...

    Authors: Xiaowei Zhang, Yuchen Wu, Xuefei Sun, Qu Cui, Xueyan Bai, Gehong Dong, Zifen Gao, Yaming Wang, Chunji Gao, Shengjun Sun, Nan Ji and Yuanbo Liu
    Citation: BMC Cancer 2022 22:190
    Content type: Research article Published on:

  41. Following sentinel lymph node biopsy (SLNB), the axillary recurrence rate is very low although SLNB has a false-negative rate of 5–10%. In the ACOSOG Z0011 trial, non-sentinel positive-lymph nodes were found i...

    Authors: Ji Gwang Jung, Se Hyun Ahn, Seeyoun Lee, Eun-Kyu Kim, Jai Min Ryu, Seho Park, Woosung Lim, Yong Sik Jung, Il Yong Chung, Joon Jeong, Ji Hyun Chang, Kyung Hwan Shin, Jung Min Chang, Woo Kyung Moon and Wonshik Han
    Citation: BMC Cancer 2022 22:189
    Content type: Study protocol Published on:

  42. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) are involving in the tumorigenesis and metastasis of lung cancer. The aim of the study is to systematically characterize the lncRNA-associate...

    Authors: Yuan Xu, Guofu Lin, Yifei Liu, Xianbin Lin, Hai Lin, Zhifeng Guo, Yingxuan Xu, Qinhui Lin, Shaohua Chen, Jiansheng Yang and Yiming Zeng
    Citation: BMC Cancer 2022 22:188
    Content type: Research Published on:

  44. Pancreatic ductal adenocarcinoma (PDAC) is the major subtype of pancreatic cancer and head PDACs show distinct characteristics from body/tail PDACs. With limited studies based on Asian population, the mutation...

    Authors: Yefan Yang, Ying Ding, Yuxi Gong, Sha Zhao, Mingna Li, Xiao Li, Guoxin Song, Boya Zhai, Jin Liu, Yang Shao, Liuqing Zhu, Jiaohui Pang, Yutong Ma, Qiuxiang Ou, Xue Wu and Zhihong Zhang
    Citation: BMC Cancer 2022 22:186
    Content type: Research Published on:

  45. The number of young patients with hepatocellular carcinoma (HCC) is increasing, but whether patients of different ages have a survival advantage is unclear. This study was conducted to investigate whether age ...

    Authors: Huiwen Yan, Xinhui Wang, Xiaoli Liu, Peng Wang, Lihua Yu, Dongdong Zhou and Zhiyun Yang
    Citation: BMC Cancer 2022 22:185
    Content type: Research Published on:

  46. S100A1 expression is deregulated in a variety of human malignancies, but its role in normal and malignant endometrial cells is unclear.

    Authors: Mayu Nakagawa, Shyoma Higuchi, Miki Hashimura, Yasuko Oguri, Toshihide Matsumoto, Ako Yokoi, Yu Ishibashi, Takashi Ito and Makoto Saegusa
    Citation: BMC Cancer 2022 22:184
    Content type: Research Published on:

  47. Many breast, colorectal, and cervical cancer screening programs were disrupted due to the COVID-19 pandemic. This study aimed to estimate the short-term impact of the temporary shutdown (from March until May- ...

    Authors: Svetlana Jidkova, Sarah Hoeck, Eliane Kellen, Saskia le Cessie and Mathijs C. Goossens
    Citation: BMC Cancer 2022 22:183
    Content type: Research Published on:

  50. Radiation-induced brainstem necrosis (RIBN) is a late life-threatening complication that can appear after treatment in patients with nasopharyngeal carcinoma (NPC). However, the relationship between RIBN and r...

    Authors: Xigang Fan, Yecai Huang, Peng Xu, Yanmei Min, Jie Li, Mei Feng, Guohui Xu and Jinyi Lang
    Citation: BMC Cancer 2022 22:178
    Content type: Research Published on:

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