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  1. Prognostic indicators, treatments, and survival estimates vary by cancer type. Therefore, disease-specific models are needed to estimate patient survival. Our primary aim was to develop models to estimate surv...

    Authors: Ashley B. Anderson, Clare Grazal, Rikard Wedin, Claire Kuo, Yongmei Chen, Bryce R. Christensen, Jennifer Cullen and Jonathan A. Forsberg
    Citation: BMC Cancer 2022 22:476
    Content type: Research Published on:

  2. The Lauren classification of gastric tumors strongly correlates with prognosis. The purpose of this study was to explore the specific molecular mechanism of Lauren classification of gastric cancer and provide ...

    Authors: Yuen Tan, Qingchuan Chen, Siwei Pan, Wen An, Huimian Xu, Yao Xing and Jianjun Zhang
    Citation: BMC Cancer 2022 22:474
    Content type: Research Published on:

  3. Gastric cancer (GC) is the fifth most common cancer and the third cause of cancer deaths globally, with late diagnosis, low survival rate, and poor prognosis. This case-control study aimed to evaluate the expr...

    Authors: Maryam Koopaie, Marjan Ghafourian, Soheila Manifar, Shima Younespour, Mansour Davoudi, Sajad Kolahdooz and Mohammad Shirkhoda
    Citation: BMC Cancer 2022 22:473
    Content type: Research Published on:

  4. Poor cancer prognosis has been observed in patients with pre-existing psychiatric disorders. Therefore, we need better knowledge about the diagnosis of cancer in this patient group. The aim of the study was to...

    Authors: Line Flytkjær Virgilsen, Peter Vedsted, Alina Zalounina Falborg, Anette Fischer Pedersen, Anders Prior and Henry Jensen
    Citation: BMC Cancer 2022 22:472
    Content type: Research Published on:

  5. Scalable, multiple behavior change interventions are needed to address poor diet, inactivity, and excess adiposity among the rising number of cancer survivors. Efficacy-tested diet (RENEW) and exercise (BEAT C...

    Authors: Dori Pekmezi, Kevin Fontaine, Laura Q. Rogers, Maria Pisu, Michelle Y. Martin, Yu-Mei Schoenberger-Godwin, Robert A. Oster, Kelly Kenzik, Nataliya V. Ivankova and Wendy Demark-Wahnefried
    Citation: BMC Cancer 2022 22:471
    Content type: Study protocol Published on:

  6. We aimed to evaluate relationships between clinical outcomes and explanatory variables by network clustering analysis using data from a post marketing surveillance (PMS) study of castration-resistant prostate ...

    Authors: Hirotaka Kazama, Osamu Kawaguchi, Takeshi Seto, Kazuhiro Suzuki, Hideyasu Matsuyama, Nobuaki Matsubara, Yuki Tajima and Taro Fukao
    Citation: BMC Cancer 2022 22:470
    Content type: Research Published on:

  7. The prognosis of patients with lung cancer who demonstrate pleural plaques intraoperatively, which may be associated with exposure to asbestos, is unclear. Here, we compared the clinicopathological characteris...

    Authors: Atsushi Kagimoto, Takeshi Mimura, Atsushi Kamigaichi and Yoshinori Yamashita
    Citation: BMC Cancer 2022 22:469
    Content type: Research Published on:

  8. Research in treatment of non-small cell lung cancer (NSCLC) has shown promising results with stereotactic ablative radiotherapy (SABR) of oligometastatic disease, wherein distant disease may be limited to one ...

    Authors: Inderdeep Dhaliwal, Shayan Kassirian, Michael A. Mitchell, Mehdi Qiabi, Andrew Warner, Alexander V. Louie, Harvey H. Wong, Christine M. McDonald, Jason Rajchgot and David A. Palma
    Citation: BMC Cancer 2022 22:468
    Content type: Study protocol Published on:

  11. Laryngeal cancer represents a common malignancy that originates from the larynx, with unfavorable prognosis. Herein, this study systematically analyzed the immune signatures of laryngeal cancer and to evaluate...

    Authors: Li Ren, Ping Li, Zhouping Li and Quan Chen
    Citation: BMC Cancer 2022 22:465
    Content type: Research Published on:

  12. At Silkeborg Regional Hospital, Denmark, the number of stage IA lung cancer increased after implementation of increased use of CT investigations and a corresponding reduction in chest X-ray. The aim of the pre...

    Authors: Charlotte Hyldgaard, Christian Trolle, Stefan Markus Walbom Harders, Henriette Engberg, Torben Riis Rasmussen and Henrik Møller
    Citation: BMC Cancer 2022 22:464
    Content type: Research Published on:

  14. Long course radiotherapy plus neoadjuvant chemotherapy followed by resection (total mesorectal excision, TME) has accepted widespread recognized in the treatment of locally advanced rectal cancer (LARC). Tisle...

    Authors: Zhengyang Yang, Xiao Zhang, Jie Zhang, Jiale Gao, Zhigang Bai, Wei Deng, Guangyong Chen, Yongbo An, Yishan Liu, Qi Wei, Jiagang Han, Ang Li, Gang Liu, Yi Sun, Dalu Kong, Hongwei Yao…
    Citation: BMC Cancer 2022 22:462
    Content type: Study protocol Published on:

  15. The advantages of prophylactic central lymph node dissection (CLND) for clinically node-negative patients remained a great deal of controversies. Our research was aimed to analyze the relationship between cerv...

    Authors: Zheng Zhang, Xin Zhang, Yifei Yin, Shuangshuang Zhao, Keke Wang, Mengyuan Shang, Baoding Chen and Xincai Wu
    Citation: BMC Cancer 2022 22:461
    Content type: Research Published on:

  16. Whether an oxaliplatin- or cisplatin-based regimen is more optimal for treating elderly patients with advanced gastric cancer, in terms of survival and adverse events remains unclear.

    Authors: Takashi Chinen, Yusuke Sasabuchi, Hiroki Matsui, Hironori Yamaguchi and Hideo Yasunaga
    Citation: BMC Cancer 2022 22:460
    Content type: Research Published on:

  18. To independently assess the impact of mandatory testing using an extended DPYD variant panel (ToxNav®) and consequent dose adjustment of Capecitabine/5-FU on recorded quantitative toxicity, symptoms of depress...

    Authors: Apostolos Tsiachristas, Grant Vallance, Rositsa Koleva-Kolarova, Harriet Taylor, Luke Solomons, Giovanni Rizzo, Catherine Chaytor, Junel Miah, Sarah Wordsworth and A. Bassim Hassan
    Citation: BMC Cancer 2022 22:458
    Content type: Research Published on:

  19. Glioma is one of the main causes of cancer-related mortality worldwide and is associated with high heterogeneity. However, the key players determining the fate of glioma remain obscure. In the present study, w...

    Authors: Jie Zhang, Zhangchao Guo, Qiangli Xie, Chuanhong Zhong, Xiangyu Gao and Qiumei Yang
    Citation: BMC Cancer 2022 22:457
    Content type: Research Published on:

  20. Incidence of cervical cancer has been reduced by organized screening while for vaginal and vulvar cancers no systematic screening has been implemented. All these cancers are associated with human papilloma vir...

    Authors: Kari Hemminki, Anna Kanerva, Asta Försti and Akseli Hemminki
    Citation: BMC Cancer 2022 22:456
    Content type: Research Published on:

  21. The study conducted a multicenter study in China to explore the learning curve of contrast enhanced ultrasound (CEUS) for sentinel lymph nodes (SLNs), the feasibility of using this technique for the localizati...

    Authors: Juan Li, Hui Li, Ling Guan, Yun Lu, Weiwei Zhan, Yijie Dong, Peng Gu, Jian Liu, Wen Cheng, Ziyue Na, Lina Tang, Zhongshi Du, Lichun Yang, Saiping Hai, Chen Yang, Qingqiu Zheng…
    Citation: BMC Cancer 2022 22:455
    Content type: Research Published on:

  22. Syphilis is an infectious disease that is at least discussed to be premalignant. This potential, combined with its general pathological impact, raises the question if syphilis increases mortality in oral cance...

    Authors: Moritz Hertel, Leonie Hagedorn, Andrea Maria Schmidt-Westhausen, Henrik Dommisch, Max Heiland, Robert Preissner and Saskia Preissner
    Citation: BMC Cancer 2022 22:454
    Content type: Research Published on:

  23. Abnormal expression of long non-coding RNAs (lncRNAs) has been shown to be associated with the pathogenesis of cancers, including colorectal cancer (CRC). It has been reported that LINC00022 is highly expresse...

    Authors: Lingling Xu, Hongmei He, Yu Shang, Xiaona Qu and Jinghua Sun
    Citation: BMC Cancer 2022 22:453
    Content type: Research Published on:

  24. Although survival based outcomes of lung cancer patients have been well developed, institutional transition of cancer care, that is, when patients transfer from primary visiting hospitals to other hospitals, a...

    Authors: Kyu-Tae Han, Jongwha Chang, Dong-Woo Choi, Seungju Kim, Dong Jun Kim, Yoon-Jung Chang and Sun Jung Kim
    Citation: BMC Cancer 2022 22:452
    Content type: Research Published on:

  25. Nonclustered mouse protocadherin genes (Pcdh) encode proteins with a typical single ectodomain and a cytoplasmic domain with conserved motifs completely different from those of classic cadherins. Alternative spli...

    Authors: Irene Kleinberger, Ellen Sanders, Katrien Staes, Marleen Van Troys, Shinji Hirano, Tino Hochepied, Kelly Lemeire, Liesbet Martens, Christophe Ampe and Frans van Roy
    Citation: BMC Cancer 2022 22:451
    Content type: Research Published on:

  26. Currently the five-year survival of childhood cancer is up to 80% due to improved treatment modalities. However, the majority of childhood cancer survivors develop late effects including infertility. Survivors...

    Authors: M. E. Madeleine van der Perk, Eglė Stukaitė-Ruibienė, Žana Bumbulienė, Goda Elizabeta Vaitkevičienė, Annelies M. E. Bos, Marry M. van den Heuvel-Eibrink and Jelena Rascon
    Citation: BMC Cancer 2022 22:450
    Content type: Research Published on:

  27. The aim of the present study was to assess the prevalence of deficient mismatch repair (MMR) in Chinese ovarian clear cell carcinoma (CCC) patients and its association with clinicopathologic features.

    Authors: Shuang Ye, Shuling Zhou, Siyuan Zhong, Boer Shan, Wenhua Jiang, Wentao Yang, Xu Cai and Huijuan Yang
    Citation: BMC Cancer 2022 22:449
    Content type: Research Published on:

  28. Baculoviral IAP repeat containing 5 (BIRC5) is overexpressed and plays as a key regulator in the progression of various human carcinomas. The inflammatory tumor microenvironment (ITM) is closely associated wit...

    Authors: Yang Zhao, Songlin Liu, Shuhang Li, Gang Zhang, Aimin Tian and Yinxu Wan
    Citation: BMC Cancer 2022 22:448
    Content type: Research Published on:

  29. The receptor tyrosine kinase (RTK) epidermal growth factor receptor (EGFR) is overexpressed and an important therapeutic target in Head and Neck cancer (HNC). Cetuximab is currently the only EGFR-targeting age...

    Authors: Mari Iida, Nellie K. McDaniel, Kourtney L. Kostecki, Noah B. Welke, Carlene A. Kranjac, Peng Liu, Colin Longhurst, Justine Y. Bruce, Seungpyo Hong, Ravi Salgia and Deric L. Wheeler
    Citation: BMC Cancer 2022 22:447
    Content type: Research Published on:

  31. Standard groin treatment in recurrent vulvar cancer consists of uni- or bilateral inguinofemoral lymphadenectomy (IFL), whereas in the primary setting women with selected unifocal tumours will undergo a sentin...

    Authors: Helena C. van Doorn, Maaike H. M. Oonk, Guus Fons, Katja N. Gaarenstroom, Joanne de Hullu, Joost van Rosmalen and Heleen J. van Beekhuizen
    Citation: BMC Cancer 2022 22:445
    Content type: Study Protocol Published on:

  32. Recurrences remain an important problem in laryngeal squamous cell carcinoma. Little has been described about histological characteristics of the primary laryngeal tumor that may be associated with recurrences...

    Authors: Lilian N. Ruiter, Boukje A. C. van Dijk, Annette H. Bruggink, Patricia A. H. Doornaert, Marielle E. P. Philippens, Remco de Bree, Carla H. van Gils and Stefan M. Willems
    Citation: BMC Cancer 2022 22:444
    Content type: Research Published on:

  33. Radical surgery is the mainstream treatment for patients presenting with advanced primary or recurrent gastrointestinal cancers; however, the rate of postoperative complications is exceptionally high. The curr...

    Authors: Daniel Steffens, Jane Young, Bernhard Riedel, Rachael Morton, Linda Denehy, Alexander Heriot, Cherry Koh, Qiang Li, Adrian Bauman, Charbel Sandroussi, Hilmy Ismail, Mbathio Dieng, Nabila Ansari, Neil Pillinger, Sarah O’Shannassy, Sam McKeown…
    Citation: BMC Cancer 2022 22:443
    Content type: Study protocol Published on:

  34. Oral mucositis (OM) is known to be the most common and challenging side effect of conditioning chemotherapy in haematopoietic cell transplant (HCT). This side effect causes significant morbidity and may delay ...

    Authors: Faizah Jabr Alsulami and Sadr ul Shaheed
    Citation: BMC Cancer 2022 22:442
    Content type: Research article Published on:

  35. Colorectal cancer(CRC) patients are among the incurable groups who need comprehensive palliative care covering all aspects including physical, mental, social, and spiritual. The purpose of this study is to develo...

    Authors: Masoud Bahrami, Masoumeh Masoumy, Alireza Sadeghi and Rohallah Mosavizadeh
    Citation: BMC Cancer 2022 22:441
    Content type: Study protocol Published on:

  36. Graft-versus-host disease (GvHD) remains a major complication and limitation to successful allogeneic hematopoietic stem cell transplantation. Treatment of GvHD is challenging due to its heterogeneous nature o...

    Authors: Janina Bujan Rivera, Rea Kühl, Ulrike Zech, Anne Hendricks, Thomas Luft, Peter Dreger, Birgit Friedmann-Bette, Theresa-Maria Betz and Joachim Wiskemann
    Citation: BMC Cancer 2022 22:440
    Content type: Study protocol Published on:

  37. Authors: Sameer Ahmad Guru, Mamta Pervin Sumi, Rashid Mir, Mirza Masroor Ali Beg, Bidhan Chandra koner and Alpana Saxena
    Citation: BMC Cancer 2022 22:439
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2022 22:405

  38. Cancer metastasis is the main cause of mortality in cancer patients. However, the drugs targeting metastasis processes are still lacking, which is partially due to the short of effective in vitro model for cell i...

    Authors: Rongrong Jiang, Jiechun Huang, Xiaotian Sun, Xianglin Chu, Fangrui Wang, Jie Zhou, Qihui Fan and Liewen Pang
    Citation: BMC Cancer 2022 22:438
    Content type: Research Published on:

  39. Regulatory T cells (Tregs) play an important role in the antitumor immune response in epithelial ovarian cancer (EOC). To understand the immune-inhibitory networks of EOC, we addressed the association between ...

    Authors: Sho Sato, Hirokazu Matsushita, Daisuke Shintani, Yukari Kobayashi, Nao Fujieda, Akira Yabuno, Tadaaki Nishikawa, Keiichi Fujiwara, Kazuhiro Kakimi and Kosei Hasegawa
    Citation: BMC Cancer 2022 22:437
    Content type: Research Published on:

  40. While mechanisms contributing to the progression and metastasis of colorectal cancer (CRC) are well studied, cancer stage-specific mechanisms have been less comprehensively explored. This is the focus of this ...

    Authors: Sara Rahiminejad, Mano R. Maurya, Kavitha Mukund and Shankar Subramaniam
    Citation: BMC Cancer 2022 22:436
    Content type: Research Published on:

  41. Timely diagnosis and management of iron deficiency anemia (IDA) in colorectal cancer (CRC) patients improves overall quality of life and survival. This study assessed the proportion of CRC patients who were fo...

    Authors: Trishnee Bhurosy, Anika Jishan, Patrick M. Boland, Yen-Han Lee and Carolyn J. Heckman
    Citation: BMC Cancer 2022 22:435
    Content type: Research Published on:

  42. Patients with oesophageal and gastric cancer have a low likelihood of being cured and suffer from a broad spectrum of symptoms and problems that negatively affect their quality-of-life (QOL). Although the majo...

    Authors: Karin Dalhammar, Jimmie Kristensson, Dan Falkenback, Birgit H. Rasmussen and Marlene Malmström
    Citation: BMC Cancer 2022 22:434
    Content type: Research Published on:

  44. Malignant pleural mesothelioma (MPM) is a rare, aggressive malignancy of the pleural cavity linked to asbestos exposure. The combination of pemetrexed and platinum is a standard first-line therapy for malignan...

    Authors: Barbara Ziółkowska, Bożena Cybulska-Stopa, Dimitrios Papantoniou and Rafał Suwiński
    Citation: BMC Cancer 2022 22:432
    Content type: Research Published on:

  45. Circulating long non-coding RNAs (lncRNAs) have been demonstrated to serve as diagnostic or prognosis biomarkers for various disease. We aimed to elucidate the diagnostic efficacy of serum lncRNA SCARNA10 for ...

    Authors: Yawei Han, Wenna Jiang, Yu Wang, Meng Zhao, Yueguo Li and Li Ren
    Citation: BMC Cancer 2022 22:431
    Content type: Research Published on:

  46. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are used in treating cardiovascular diseases. Previous studies indicated that ACEIs/ARBs may benefit cancer patients by...

    Authors: Po-Chih Li, Ru-Yu Huang, Yu-Chien Yang, Kun-Pin Hsieh and Yi-Hsin Yang
    Citation: BMC Cancer 2022 22:430
    Content type: Research Published on:

  48. To evaluate the effect of regorafenib on soluble MHC class I polypeptide-related sequence A (MICA) (sMICA) level in vitro. In addition, we clinically examined whether its plasma levels were associated with reg...

    Authors: Jun Arai, Yumi Otoyama, Ken-ichi Fujita, Kaku Goto, Masayuki Tojo, Atsushi Katagiri, Hisako Nozawa, Yutaro Kubota, Takehiro Takahashi, Hiroo Ishida, Takuya Tsunoda, Natsumi Matsumoto, Keita Ogawa, Ryo Nakagawa, Ryosuke Muroyama, Naoya Kato…
    Citation: BMC Cancer 2022 22:428
    Content type: Research Published on:

  49. Diabetes is an established risk factor for endometrial cancer development but its impact on prognosis is unclear and epidemiological studies to date have produced inconsistent results. We aimed to conduct the ...

    Authors: Lauren McVicker, Christopher R. Cardwell, Lauren Edge, W Glenn McCluggage, Declan Quinn, James Wylie and Úna C. McMenamin
    Citation: BMC Cancer 2022 22:427
    Content type: Research Published on:

  50. Authors: Lenny Gallardo-Alvarado, David Cantú-de León, Rebeca Ramirez-Morales, Gabriel Santiago-Concha, Salim Barquet-Muñoz, Rosa Salcedo-Hernandez, Cinthya Reyes, Sandra Perez-Alvarez, Delia Perez-Montiel, Carlos Perez-Plasencia, Elizabeth Trejo-Duran and Juan Pablo Galicia
    Citation: BMC Cancer 2022 22:422
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2022 22:401

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