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3909 result(s) for 'lung cancer prognosis stage 4' within BMC Cancer

Page 52 of 79

  1. Despite some therapeutic advances, improvement in survival rates of unresectable and/or metastatic pancreatic ductal adenocarcinoma (PDAC) has been minimal over recent decade. We aimed to evaluate the impact o...

    Authors: Mengjiao Fan, Guochao Deng, Yue Ma, Haiyan Si, Zhikuan Wang and Guanghai Dai
    Citation: BMC Cancer 2024 24:67
    Content type: Research Published on:

  2. “Biomarker-driven targeted therapy,” the practice of tailoring patients’ treatment to the expression/activity levels of disease-specific genes/proteins, remains challenging. For example, while the anti-ERBB2 m...

    Authors: Hae Ryung Chang, Hee Seo Park, Young Zoo Ahn, Seungyoon Nam, Hae Rim Jung, Sungjin Park, Sang Jin Lee, Curt Balch, Garth Powis, Ja-Lok Ku and Yon Hui Kim
    Citation: BMC Cancer 2016 16:200
    Content type: Research article Published on:

  3. OCT4 and BIRC5 are preferentially expressed in human cancer cells and mediate cancer cell survival and tumor maintenance. However, the molecular mechanism that regulates OCT4 and BIRC5 expression is not well c...

    Authors: Lu Cao, Chunguang Li, Shuwen Shen, Yan Yan, Weidan Ji, Jinghan Wang, Haihua Qian, Xiaoqing Jiang, Zhigang Li, Mengchao Wu, Ying Zhang and Changqing Su
    Citation: BMC Cancer 2013 13:82
    Content type: Research article Published on:

  5. Renal cell carcinoma (RCC) incidence is highest in highly developed countries and it is the seventh most common neoplasm diagnosed. RCC management include nephrectomy and targeted therapies. Type 1 insulin-lik...

    Authors: Adam F. Tracz, Cezary Szczylik, Camillo Porta and Anna M. Czarnecka
    Citation: BMC Cancer 2016 16:453
    Content type: Debate Published on:

  6. MiRNAs are often deregulated in colorectal cancer and might function as tumor suppressors or as oncogenes. They participate in controlling key signaling pathways involved in proliferation, invasion and apoptos...

    Authors: Edita Baltruskeviciene, Diana Schveigert, Vaidotas Stankevicius, Ugnius Mickys, Tadas Zvirblis, Jaroslav Bublevic, Kestutis Suziedelis and Eduardas Aleknavicius
    Citation: BMC Cancer 2017 17:607
    Content type: Research article Published on:

  7. Pancreatic cancer is the fourth commonest cause of death from cancer in men and women. Advantages in surgical techniques, radiation therapy techniques, chemotherapeutic regimes, and different combined-modality...

    Authors: R Krempien, MW Muenter, PE Huber, S Nill, H Friess, C Timke, B Didinger, P Buechler, S Heeger, KK Herfarth, A Abdollahi, MW Buchler and J Debus
    Citation: BMC Cancer 2005 5:131
    Content type: Study protocol Published on:

  8. Germ cell tumors and sex cord stromal tumors are rare cancers of the ovary. They mainly affect young women and are associated with a high survival rate. The standard treatment mainly involves conservative surg...

    Authors: François Gernier, Djihane Ahmed-Lecheheb, Patricia Pautier, Anne Floquet, Cédric Nadeau, Sophie Frank, Jérôme Alexandre, Frédéric Selle, Dominique Berton-Rigaud, Elsa Kalbacher, Hubert Orfeuvre, Alain Lortholary, Paule Augereau, Fabien Labombarda, Lionel Perrier, Jean-Michel Grellard…
    Citation: BMC Cancer 2021 21:1147
    Content type: Study protocol Published on:

  9. Oesophageal cancer has a high metastatic potential and poor prognosis, with a significant risk of recurrence after radical resection. However, resected pancreatic metastasis from oesophageal cancer is rare.

    Authors: Wataru Koizumi, Minoru Kitago, Masahiro Shinoda, Hiroshi Yagi, Yuta Abe, Go Oshima, Shutaro Hori, Kenta Inomata, Hirofumi Kawakubo, Miho Kawaida and Yuko Kitagawa
    Citation: BMC Cancer 2019 19:320
    Content type: Case report Published on:

  10. Smoking cessation is a key step towards improving cancer care and outcomes. However, smoking cessation interventions are underprovided in oncology settings. Within Jordan’s only comprehensive oncology center, ...

    Authors: F. I. Hawari, N. A. Obeidat, D. Rimawi and K. Jamal
    Citation: BMC Cancer 2019 19:580
    Content type: Research article Published on:

  11. Disseminated tumor cells (DTCs) can be detected using ultrasensitive immunocytochemical assays and their presence in the bone marrow can predict the subsequent occurrence of overt metastasis formation and meta...

    Authors: Stefan Werner, Hauke Stamm, Mutiha Pandjaitan, Dirk Kemming, Benedikt Brors, Klaus Pantel and Harriet Wikman
    Citation: BMC Cancer 2015 15:896
    Content type: Research article Published on:

  12. Fibulin-5 has been considered as a tumor suppressor through inhibiting tumor growth and invasion. Reduced expression of Fibulin-5 is frequently observed in various human cancers. In this study, we investigate ...

    Authors: Kangsheng Tu, Changwei Dou, Xin Zheng, Chao Li, Wei Yang, Yingmin Yao and Qingguang Liu
    Citation: BMC Cancer 2014 14:938
    Content type: Research article Published on:

  13. To assess the prognostic factors and investigate the optimal treatment of gastric mixed adenoneuroendocrine tumors.

    Authors: Jian-Wei Xie, Jun Lu, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ze-Ning Huang, Ju-Li Lin, Chao-Hui Zheng, Ping Li and Chang-Ming Huang
    Citation: BMC Cancer 2018 18:1021
    Content type: Research article Published on:

  14. Although current therapy for patients with early-stage squamous cell carcinoma of the head and neck (SCCHN) is potentially curative, the recurrence rate is high. Patients with recurrent or metastatic (R/M) SCC...

    Authors: Prianka Singh, Bryan Bennett, Tom Bailey, Gavin Taylor-Stokes, Ivana Rajkovic, Marta Contente, Sharon Curtis and Chris Curtis
    Citation: BMC Cancer 2021 21:854
    Content type: Research Published on:

  16. The procoagulant state in cancer increases the thrombotic risk, but also supports tumor progression. To investigate the molecular mechanisms controlling cancer and hemostasis, we conducted a case-control study...

    Authors: Mari Tinholt, Marte Kathrine Viken, Anders Erik Dahm, Hans Kristian Moen Vollan, Kristine Kleivi Sahlberg, Øystein Garred, Anne-Lise Børresen-Dale, Anne Flem Jacobsen, Vessela Kristensen, Ida Bukholm, Rolf Kåresen, Ellen Schlichting, Grethe Skretting, Benedicte Alexandra Lie, Per Morten Sandset and Nina Iversen
    Citation: BMC Cancer 2014 14:845
    Content type: Research article Published on:

  17. Gastric cancer is one of the most common and lethal type of cancer worldwide. Infection with Helicobacter pylori (H. pylori) is recognized as the major cause of gastric cancer. However, it remains unclear the mec...

    Authors: Ivonne Lozano-Pope, Arnika Sharma, Michael Matthias, Kelly S. Doran and Marygorret Obonyo
    Citation: BMC Cancer 2017 17:133
    Content type: Research article Published on:

  19. HER2 (ERBB2 or HER2/neu) is a tyrosine-kinase increasing cell proliferation. Overexpression/amplification of HER2 is correlated with worse prognosis in solid malignancies. Consequently, HER2 targeting is estab...

    Authors: Patrick Sven Plum, Florian Gebauer, Max Krämer, Hakan Alakus, Felix Berlth, Seung-Hun Chon, Lars Schiffmann, Thomas Zander, Reinhard Büttner, Arnulf Heinrich Hölscher, Christiane Josephine Bruns, Alexander Quaas and Heike Loeser
    Citation: BMC Cancer 2019 19:38
    Content type: Research article Published on:

  20. Heterogeneity in bladder cancer results in variable clinical outcomes, posing challenges for clinical management of this malignancy. Recent studies suggest both tumor suppressive and oncogenic role of PPARγ in...

    Authors: Shidong Lv, Wei Wang, Hongyi Wang, Yongtong Zhu and Chengyong Lei
    Citation: BMC Cancer 2019 19:204
    Content type: Research article Published on:

  21. FBXO11, a member of the F-box protein family, regulates the cell-cycle by promoting the degradation of Bcl-6 and p53. This protein has been implicated in the progression of several cancers, including renal cel...

    Authors: Bo Fan, Wei Wang, Xianping Zhang, Min Sun, Xiaogang Wang, Zhiqi Chen, Wankai Liu, Qun Wang, Na Yu and Xiancheng Li
    Citation: BMC Cancer 2019 19:534
    Content type: Research article Published on:

  22. Expression and activation of the cMET receptor have been implicated in tumor progression and resistance to chemotherapy in human pancreatic cancer. In this regard we assessed the effects of targeting cMET in p...

    Authors: Franziska Brandes, Katharina Schmidt, Christine Wagner, Julia Redekopf, Hans Jürgen Schlitt, Edward Kenneth Geissler and Sven Arke Lang
    Citation: BMC Cancer 2015 15:71
    Content type: Research article Published on:

  23. HuR is an RNA-binding protein that post-transcriptionally modulates the expressions of various target genes implicated in carcinogenesis, such as CCNA2 encoding cyclin A. No prior study attempted to evaluate the ...

    Authors: Peir-In Liang, Wei-Ming Li, Yu-Hui Wang, Ting-Feng Wu, Wen-Ren Wu, Alex C Liao, Kun-Hung Shen, Yu-Ching Wei, Chung-Hsi Hsing, Yow-Ling Shiue, Hsuan-Ying Huang, Han-Ping Hsu, Li-Tzon Chen, Ching-Yih Lin, Chein Tai, Chun-Mao Lin…
    Citation: BMC Cancer 2012 12:611
    Content type: Research article Published on:

  24. Colorectal cancer (CRC) is the second most common cause of all cancer deaths in Europe and the Western world with a lifetime risk of approximately 5%. Despite several improvements in the treatment of patients ...

    Authors: Susen Burock, Severin Daum, Ulrich Keilholz, Konrad Neumann, Wolfgang Walther and Ulrike Stein
    Citation: BMC Cancer 2018 18:297
    Content type: Study protocol Published on:

  25. The aim of the study was to enhance colorectal cancer prognostication by integrating single nucleotide polymorphism (SNP) and gene expression (GE) microarrays for genomic and transcriptional alteration detecti...

    Authors: Ming-Hung Shen, Chi-Jung Huang, Thien-Fiew Ho, Chih-Yi Liu, Ying-Yih Shih, Ching-Shui Huang and Chi-Cheng Huang
    Citation: BMC Cancer 2022 22:590
    Content type: Research Published on:

  26. Immune checkpoint inhibitor (ICI) therapy has become a viable treatment strategy in bladder cancer. However, treatment responses vary, and improved biomarkers are needed. Crucially, the characteristics of immu...

    Authors: Max Jung, Michael Rose, Ruth Knuechel, Chiara Loeffler, Hannah Muti, Jakob Nikolas Kather and Nadine T. Gaisa
    Citation: BMC Cancer 2023 23:113
    Content type: Research Published on:

  27. Deregulated signal transducer and activator of transcription 3 (STAT3) signaling has been well documented in certain cancers. Alterations in specific negative regulators, such as protein inhibitor of activated...

    Authors: Sheau-Fang Yang, Ming-Feng Hou, Fang-Ming Chen, Fu Ou-Yang, Yang-Chang Wu, Chee-Yin Chai and Yao-Tsung Yeh
    Citation: BMC Cancer 2016 16:20
    Content type: Research article Published on:

  29. Increasing evidence shows that liver-specific long non-coding RNAs (lncRNAs) play important roles in the development of hepatocellular carcinoma (HCC). We identified a novel liver-specific lncRNA, FAM99A, and ...

    Authors: Meile Mo, Xiaoyun Ma, Yihuan Luo, Chao Tan, Bihu Liu, Peng Tang, Qian Liao, Shun Liu, Hongping Yu, Dongping Huang, Xiaoyun Zeng and Xiaoqiang Qiu
    Citation: BMC Cancer 2022 22:1098
    Content type: Research Published on:

  30. Ovarian cancer still has a relatively poor prognosis due to the frequent occurrence of drug resistance, making the identification of new therapeutic targets an important goal. We have studied the role of HOX gene...

    Authors: Richard Morgan, Lynn Plowright, Kevin J Harrington, Agnieszka Michael and Hardev S Pandha
    Citation: BMC Cancer 2010 10:89
    Content type: Research article Published on:

  31. It has been shown that a subgroup of patients with differentiated thyroid cancer (DTC) and medullary thyroid carcinoma (MTC) would progress to advanced stages of thyroid cancer. Therefore, the present study wa...

    Authors: Zohreh Maghsoomi, Zahra Emami, Ramin Malboosbaf, Mojtaba Malek and Mohammad E. Khamseh
    Citation: BMC Cancer 2021 21:579
    Content type: Research article Published on:

  32. A high prevalence of postoperative complications is closely associated with a worse short- and long-term outcome. This current study aimed to investigate potential risk factors including albumin-to-fibrinogen ...

    Authors: Xuexue You, Qun Zhou, Jie Song, Linguang Gan, Junping Chen and Huachun Shen
    Citation: BMC Cancer 2019 19:931
    Content type: Research article Published on:

  33. Long-term prognostic significance of loss of heterozygosity on chromosome 9p21 for localized renal cell carcinoma following surgery remains unreported. The study assessed the frequency of deletions of differen...

    Authors: Ismail El-Mokadem, Alison Lim, Thomas Kidd, Katherine Garret, Norman Pratt, David Batty, Stewart Fleming and Ghulam Nabi
    Citation: BMC Cancer 2016 16:546
    Content type: Research article Published on:

  34. UbcH10 participates in proper metaphase to anaphase transition, and abrogation of UbcH10 results in the premature separation of sister chromatids. To assess the potential role of UbcH10 in colon cancer progres...

    Authors: Takeo Fujita, Hirokuni Ikeda, Naruto Taira, Shinji Hatoh, Minoru Naito and Hiroyoshi Doihara
    Citation: BMC Cancer 2009 9:87
    Content type: Research article Published on:

  35. Peritoneal metastasis (PM) in gastric cancer (GC) is characterized by diffusely infiltrating and proliferating cancer cells accompanied by extensive stromal fibrosis in the peritoneal space. The prognosis of G...

    Authors: Daisuke Fujimori, Jun Kinoshita, Takahisa Yamaguchi, Yusuke Nakamura, Katsuya Gunjigake, Takashi Ohama, Koichi Sato, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Tetsuo Ohta and Sachio Fushida
    Citation: BMC Cancer 2020 20:1014
    Content type: Research article Published on:

  36. The process of diagnosis and management of solitary pulmonary nodules (SPNs) between 1 and 3 cm is not standardized. This multicentre study investigated how diagnosis of newly discovered SPNs is managed in rou...

    Authors: Kazem Alzahouri, Michel Velten, Patrick Arveux, Marie-Christine Woronoff-Lemsi, Damien Jolly and Francis Guillemin
    Citation: BMC Cancer 2008 8:93
    Content type: Research article Published on:

  37. Bone metastasis is relatively uncommon in gastric cancer patients, but its incidence has been rising. Early detection of bone metastasis is important in preventing complications related to bone metastasis such...

    Authors: Sun Min Lim, Youn Nam Kim, Ki Hyun Park, Beodeul Kang, Hong Jae Chon, Chan Kim, Joo Hoon Kim and Sun Young Rha
    Citation: BMC Cancer 2016 16:385
    Content type: Research article Published on:

  38. Desmoplastic malignant pleural mesothelioma (DMM) is rare histological subtype of diffuse malignant pleural mesothelioma (MPM), accounting for 5–10 % of cases. It has a poor prognosis, with direct invasion of ...

    Authors: Kana Hashimoto, Yusuke Okuma, Yukio Hosomi and Tsunekazu Hishima
    Citation: BMC Cancer 2016 16:718
    Content type: Case report Published on:

  39. Despite increasing use, symptomatic venous thromboembolism (VTE) associated with peripherally inserted central catheter (PICC) is a common complication in nonmetastatic nasopharyngeal carcinoma (NPC) patients.

    Authors: Yu-Jing Liang, Lin-Quan Tang, Xue-Song Sun, Yu-Ying Fan, Jin-Jie Yan, Yu-Yun Du, Shan-Shan Guo, Li-Ting Liu, Hao-Jun Xie, Sai-Lan Liu, Qing-Nan Tang, Xiao-Yun Li, Hai-Qiang Mai and Qiu-Yan Chen
    Citation: BMC Cancer 2018 18:1297
    Content type: Research article Published on:

  40. Tertiary lymphoid structures (TLS) are highly organized immune cell aggregates that develop at sites of inflammation or infection in non-lymphoid organs. Despite the described role of inflammation in tumor pro...

    Authors: Stine L Figenschau, Silje Fismen, Kristin A Fenton, Christopher Fenton and Elin S Mortensen
    Citation: BMC Cancer 2015 15:101
    Content type: Research article Published on:

  41. Colorectal cancer (CRC) is the third most prevalent cancer in the world, yet the sensitivity and specificity of biomarkers for CRC diagnosis are insufficient. In the present study, we performed a protein micro...

    Authors: Takahiro Arasawa, Takaki Hiwasa, Akiko Kagaya, Tetsuro Maruyama, Masaya Uesato, Masayuki Kano, Sohei Kobayashi, Hirotaka Takizawa, Katsuro Iwase, Fumio Nomura, Kazuyuki Matsushita and Hisahiro Matsubara
    Citation: BMC Cancer 2023 23:356
    Content type: Research Published on:

  43. Aberrant promoter CpG island hypermethylation is associated with transcriptional silencing. Tumor suppressor genes are the key targets of hypermethylation in breast cancer and therefore may lead to malignancy ...

    Authors: Jia Xu, Priya B Shetty, Weiwei Feng, Carol Chenault, Robert C Bast Jr, Jean-Pierre J Issa, Susan G Hilsenbeck and Yinhua Yu
    Citation: BMC Cancer 2012 12:243
    Content type: Research article Published on:

  44. Immunotherapy is a vital component in cancer treatment. However, due to the complex genetic bases of cancer, a clear prediction index for efficacy has not been established. Tumor mutation burden (TMB) is one o...

    Authors: Liwei Wang, Fu Chen, Rui Liu, Lei Shi, Guosheng Zhao and Zhengjian Yan
    Citation: BMC Cancer 2021 21:379
    Content type: Research article Published on:

  45. The gene encoding fibroblast growth factor receptor 1 (FGFR1) is emerging as a therapeutic and prognostic biomarker in various cancer types, including head and neck squamous cell carcinoma (SCC). Here, we investi...

    Authors: Eun Kyung Kim, Yoon Ah Cho, Yoon Woo Koh, Hyang Ae Shin, Byoung Chul Cho and Sun Och Yoon
    Citation: BMC Cancer 2020 20:348
    Content type: Research article Published on:

  46. Optimization of chemotherapy effectiveness in metastatic colorectal cancers (mCRC) is a major endpoint to enhance the possibility of curative intent surgery. FOLFIRI3 has shown promising results as second-line...

    Authors: Stefano Kim, Erion Dobi, Marine Jary, Franck Monnien, Elsa Curtit, Thierry NGuyen, Zaher Lakkis, Bruno Heyd, Serge Fratte, Denis Cléau, Najib Lamfichekh, Virginie Nerich, Boris Guiu, Martin Demarchi and Christophe Borg
    Citation: BMC Cancer 2013 13:611
    Content type: Research article Published on:

  47. Endometrial carcinoma (EC) is a malignant tumor of the female reproductive tract that has been associated with increased morbidity and mortality. This study aimed to identify biomarkers and potential therapeut...

    Authors: Qirong Hao, Hongqin Wu, Erniao Liu and Lina Wang
    Citation: BMC Cancer 2023 23:995
    Content type: Research Published on:

  48. To retrospectively investigate the clinical characteristics, initial treatment, relapse, therapy outcome, and prognosis of Chinese patients with primary testicular lymphoma (PTL) through analysis of the cases ...

    Authors: Bo Chen, De-Hong Cao, Li Lai, Jian-Bing Guo, Ze-Yu Chen, Yin Huang, Shi Qiu, Tian-Hai Lin, Yue Gou, Na Ma, Lu Yang, Liang-Ren Liu and Qiang Wei
    Citation: BMC Cancer 2020 20:220
    Content type: Research article Published on:

  49. The epidermal growth factor receptor (EGFR) is a potential target of anticancer therapy in gastric cancer. However, its prognostic role in metastatic gastric or gastroesophageal junction (GE) cancer has not be...

    Authors: Akin Atmaca, Dominique Werner, Claudia Pauligk, Kristina Steinmetz, Ralph Wirtz, Hans-Michael Altmannsberger, Elke Jäger and Salah-Eddin Al-Batran
    Citation: BMC Cancer 2012 12:524
    Content type: Research article Published on:

  50. Brain metastases (BMs) are the most frequent intracranial tumours associated with poor clinical outcomes. Radiotherapy is essential in the treatment of these tumours, although the optimal radiation strategy re...

    Authors: Kunning Zhang, Tian Zhang, Zhoubo Guo, Fangdong Zhao, Jiacheng Li, Yanqi Li, Yang Li, Xiaoyue Wu, Xi Chen, Wencheng Zhang, Qingsong Pang and Ping Wang
    Citation: BMC Cancer 2023 23:1240
    Content type: Research Published on:

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