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316 result(s) for 'serum psa 29' within BMC Cancer

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  1. Breast cancer in women and prostate cancer are the first and second leading tumour respectively in terms of incidence world-wide. Our objective is to ascertain the similarities and differences between mortalit...

    Authors: Gonzalo López-Abente, Sergio Mispireta and Marina Pollán
    Citation: BMC Cancer 2014 14:874
    Content type: Research article Published on:

  2. Prostate cancer is caused by genomic aberrations in normal epithelial cells, however clinical translation of findings from analyses of cancer cells alone has been very limited. A deeper understanding of the tu...

    Authors: Stefano Mangiola, Patrick McCoy, Martin Modrak, Fernando Souza-Fonseca-Guimaraes, Daniel Blashki, Ryan Stuchbery, Simon P. Keam, Michael Kerger, Ken Chow, Chayanica Nasa, Melanie Le Page, Natalie Lister, Simon Monard, Justin Peters, Phil Dundee, Scott G. Williams…
    Citation: BMC Cancer 2021 21:846
    Content type: Research article Published on:

  3. Suppressor of cytokine signaling 1 (SOCS1) is considered a tumor suppressor due to frequent epigenetic and micro-RNA-mediated repression of its gene expression in diverse cancers. In prostate cancer (PCa), ele...

    Authors: Martin Chevrier, Diwakar Bobbala, Alberto Villalobos-Hernandez, Md Gulam Musawwir Khan, Sheela Ramanathan, Caroline Saucier, Gerardo Ferbeyre, Sameh Geha and Subburaj Ilangumaran
    Citation: BMC Cancer 2017 17:157
    Content type: Research article Published on:

  4. Cancer of unknown primary site(CUPs) is a metastatic syndrome with an unidentifiable primary tumor, even after extensive workup to seek the primary site. CUPs accounts for about 3%-5% of the total number of al...

    Authors: HongLiang Yang, Feng He, Wen Xu and Zeng Cao
    Citation: BMC Cancer 2022 22:1372
    Content type: Research Published on:

  5. A common treatment option for men with prostate cancer is androgen deprivation therapy (ADT). However, men undergoing ADT may experience physical side effects, changes in quality of life and sometimes psychiat...

    Authors: Monique M Cherrier, Paul R Borghesani, Amy L Shelton and Celestia S Higano
    Citation: BMC Cancer 2010 10:1
    Content type: Research article Published on:

  6. YKL-40 (chitinase-3-like-1) is a member of "mammalian chitinase-like proteins". The protein is expressed in many types of cancer cells and the highest plasma YKL-40 levels have been found in patients with meta...

    Authors: Estrid VS Høgdall, Merete Ringsholt, Claus K Høgdall, Ib Jarle Christensen, Julia S Johansen, Susanne K Kjaer, Jan Blaakaer, Lene Ostenfeld-Møller, Paul A Price and Lise H Christensen
    Citation: BMC Cancer 2009 9:8
    Content type: Research article Published on:

  7. Prostate cancer is the second leading cause of male cancer death in developed countries. Although the role of angiogenesis in its progression is well established, the efficacy of anti-angiogenic therapy is not...

    Authors: Alessandra Fiorio Pla, Alessia Brossa, Michela Bernardini, Tullio Genova, Guillaume Grolez, Arnaud Villers, Xavier Leroy, Natalia Prevarskaya, Dimitra Gkika and Benedetta Bussolati
    Citation: BMC Cancer 2014 14:939
    Content type: Research article Published on:

  8. Androgen-independent prostate adenocarcinomas are responsible for about 6% of overall cancer deaths in men.

    Authors: Elizabeth Devilard, Franck Bladou, Olivier Ramuz, Gilles Karsenty, Jean-Philippe Dalès, Gwenaëlle Gravis, Catherine Nguyen, François Bertucci, Luc Xerri and Daniel Birnbaum
    Citation: BMC Cancer 2006 6:272
    Content type: Research article Published on:

  9. Few studies have taken risk of competing events into account when examining the relationship between cholesterol and prostate cancer incidence, and few studies have a follow-up over several decades. We aimed t...

    Authors: Trond Heir, Ragnhild Sørum Falk, Trude Eid Robsahm, Leiv Sandvik, Jan Erikssen and Steinar Tretli
    Citation: BMC Cancer 2016 16:643
    Content type: Research article Published on:

  10. Carbon ion Radiotherapy for prostate cancer is widely used, however reports are limited from single institute or short follow up. We performed a prospective observational study (GUNMA0702) to evaluate the feas...

    Authors: Hidemasa Kawamura, Nobuteru Kubo, Hiro Sato, Tatsuji Mizukami, Hiroyuki Katoh, Hitoshi Ishikawa, Tatsuya Ohno, Hiroshi Matsui, Kazuto Ito, Kazuhiro Suzuki and Takashi Nakano
    Citation: BMC Cancer 2020 20:75
    Content type: Research article Published on:

  11. Lymph node (LN) status is a key prognostic factor in the decision-making process of different cancer entities, including prostate cancer (PCa). Sectioning and haematoxylin and eosin (H&E) staining technique re...

    Authors: Mercè Cuadras, Jacques Planas, Ana Celma, Lucas Regis, Inés M. de Torres, M. Eugenia Semidey, Enrique Trilla and Juan Morote
    Citation: BMC Cancer 2022 22:357
    Content type: Research Published on:

  12. Prostate cancer patients with locoregional lymph node disease at diagnosis (N1M0) still have a limited prognosis despite the improvements provided by aggressive curative intent multimodal locoregional external...

    Authors: Esmée C. A. van der Sar, Arthur J. A. T. Braat, Jochem R. N. van der Voort- van Zyp, Betty S. van der Veen, Pim J. van Leeuwen, Daphne M. V. de Vries-Huizing, Jeroen M. A. Hendrikx, Marnix G. E. H. Lam and Wouter V. Vogel
    Citation: BMC Cancer 2023 23:268
    Content type: Study protocol Published on:

  13. To study the kinetic profile and clinicopathological implications of squamous cell carcinoma antigen (SCC-Ag) in cervical cancer patients who underwent surgery by a self-developed SCC-Ag single molecule assay ...

    Authors: Shuang Ye, Xiaohua Sun, Bin Kang, Fei Wu, Zhong Zheng, Libing Xiang, Mylène Lesénéchal, Fabienne Heskia, Ji Liang and Huijuan Yang
    Citation: BMC Cancer 2020 20:138
    Content type: Research article Published on:

  14. Cadmium is classified as a human lung carcinogen based on evidence from high-exposure occupational settings. Though cadmium has no physiological role, increasing evidence suggests cadmium may mimic steroid hor...

    Authors: Kirsten T Eriksen, Jytte Halkjær, Jaymie R Meliker, Jane A McElroy, Mette Sørensen, Anne Tjønneland and Ole Raaschou-Nielsen
    Citation: BMC Cancer 2015 15:177
    Content type: Research article Published on:

  15. ATP-binding cassette (ABC) transporters are transmembrane proteins responsible for the efflux of a wide variety of substrates, including steroid metabolites, through the cellular membranes. For better characte...

    Authors: Rita Demidenko, Deividas Razanauskas, Kristina Daniunaite, Juozas Rimantas Lazutka, Feliksas Jankevicius and Sonata Jarmalaite
    Citation: BMC Cancer 2015 15:683
    Content type: Research article Published on:

  16. Combining different clinical agents to target multiple pathways in prostate cancer cells, including androgen receptor (AR) signaling, is potentially an effective strategy to improve outcomes for men with metas...

    Authors: Sarah L. Carter, Margaret M. Centenera, Wayne D. Tilley, Luke A. Selth and Lisa M. Butler
    Citation: BMC Cancer 2016 16:141
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2016 16:177

  17. Cancer cell adopts peculiar metabolic strategies aimed to sustain the continuous proliferation in an environment characterized by relevant fluctuations in oxygen and nutrient levels. Monocarboxylate transporte...

    Authors: Patrizia Sanità, Mattia Capulli, Anna Teti, Giuseppe Paradiso Galatioto, Carlo Vicentini, Paola Chiarugi, Mauro Bologna and Adriano Angelucci
    Citation: BMC Cancer 2014 14:154
    Content type: Research article Published on:

  19. Aldo-keto reductase (AKR) 1C family member 3 (AKR1C3), one of four identified human AKR1C enzymes, catalyzes steroid, prostaglandin, and xenobiotic metabolism. In the prostate, AKR1C3 is up-regulated in locali...

    Authors: Mikhail G Dozmorov, Joseph T Azzarello, Jonathan D Wren, Kar-Ming Fung, Qing Yang, Jeffrey S Davis, Robert E Hurst, Daniel J Culkin, Trevor M Penning and Hsueh-Kung Lin
    Citation: BMC Cancer 2010 10:672
    Content type: Research article Published on:

  20. Prostate cancer is one of the most commonly diagnosed cancers among men. African Americans (AA) are at an increased risk of developing prostate cancer compared to European Americans (EA). miRNAs play a critica...

    Authors: Marisa Shiina, Yutaka Hashimoto, Priyanka Kulkarni, Pritha Dasgupta, Varahram Shahryari, Soichiro Yamamura, Yuichiro Tanaka and Rajvir Dahiya
    Citation: BMC Cancer 2021 21:1028
    Content type: Research Published on:

  21. To reduce sampling error associated with cancer detection in prostate needle biopsies, we explored the possibility of using fluorescence in situ hybridisation (FISH) to detect chromosomal abnormalities in the ...

    Authors: Ying Zhang, Thomas Perez, Beth Blondin, Jing Du, Ping Liu, Diana Escarzaga, John S Coon, Larry E Morrison and Katerina Pestova
    Citation: BMC Cancer 2014 14:129
    Content type: Research article Published on:

  22. Circulating total insulin-like growth factor-I (IGF-I) is an established risk factor for prostate cancer. However, only a small proportion of circulating IGF-I is free or readily dissociable from IGF-binding p...

    Authors: Tuck Seng Cheng, Urwah Noor, Eleanor Watts, Michael Pollak, Ye Wang, James McKay, Joshua Atkins, Giovanna Masala, Maria-Jose Sánchez, Antonio Agudo, Jesús Castilla, Dagfinn Aune, Sandra M. Colorado-Yohar, Luca Manfredi, Marc J. Gunter, Valeria Pala…
    Citation: BMC Cancer 2024 24:676
    Content type: Research Published on:

  23. Typical high throughput microarrays experiments compare gene expression across two specimen classes – an experimental class and baseline (or comparison) class. The choice of specimen classes is a major factor ...

    Authors: Uma R Chandran, Rajiv Dhir, Changqing Ma, George Michalopoulos, Michael Becich and John Gilbertson
    Citation: BMC Cancer 2005 5:45
    Content type: Research article Published on:

  24. The overall prognosis of non-small cell lung cancer (NSCLC) is poor, and currently only patients with localized disease are potentially curable. Therefore, preferably non-invasively determined biomarkers that ...

    Authors: Dijana Djureinovic, Victor Pontén, Per Landelius, Sahar Al Sayegh, Kai Kappert, Masood Kamali-Moghaddam, Patrick Micke and Elisabeth Ståhle
    Citation: BMC Cancer 2019 19:741
    Content type: Research article Published on:

  25. Clinical trials have been conducted to clarify the beneficial effects of VD3 (1α,25-dihydroxy vitamin D3, also known as calcitriol) treatment in prostate cancer. However, the molecular mechanisms underlying th...

    Authors: Ko Igarashi, Yoshihiro Yui, Kenta Watanabe, Jun Kumai, Yasuko Nishizawa, Chisato Miyaura, Masaki Inada and Satoru Sasagawa
    Citation: BMC Cancer 2020 20:802
    Content type: Research article Published on:

  26. The cellular effects of androgen are transduced through the androgen receptor, which controls the expression of genes that regulate biosynthetic processes, cell growth, and metabolism. Androgen signaling also ...

    Authors: Kasey Jividen, Katarzyna Z Kedzierska, Chun-Song Yang, Karol Szlachta, Aakrosh Ratan and Bryce M Paschal
    Citation: BMC Cancer 2018 18:960
    Content type: Research article Published on:

  27. Androgen deprivation therapy is commonly used to treat prostate cancer, the most common visceral cancer in men. However, various side effects often worsen physical functioning and reduce well-being among men o...

    Authors: Shabbir MH Alibhai, Daniel Santa Mina, Paul Ritvo, Catherine Sabiston, Murray Krahn, George Tomlinson, Andrew Matthew, Roanne Segal, Padraig Warde, Sara Durbano, Meagan O’Neill and Nicole Culos-Reed
    Citation: BMC Cancer 2015 15:312
    Content type: Study protocol Published on:

  28. Invasive cribriform and intraductal carcinoma (CR/IDC) is associated with adverse outcome of prostate cancer patients. The aim of this study was to determine the molecular aberrations associated with CR/IDC in...

    Authors: René Böttcher, Charlotte F. Kweldam, Julie Livingstone, Emilie Lalonde, Takafumi N. Yamaguchi, Vincent Huang, Fouad Yousif, Michael Fraser, Robert G. Bristow, Theodorus van der Kwast, Paul C. Boutros, Guido Jenster and Geert J. L. H. van Leenders
    Citation: BMC Cancer 2018 18:8
    Content type: Research article Published on:

  29. ΔNp63, a splice variant of p63, is overexpressed and exhibits oncogenic activity in many cancers including pancreatic and breast cancer and promotes cell survival by inhibiting apoptosis. Despite its role in t...

    Authors: Ram Mohan Ram Kumar, Michael M Betz, Bernhard Robl, Walter Born and Bruno Fuchs
    Citation: BMC Cancer 2014 14:559
    Content type: Research article Published on:

  30. Immunohistochemical detection of cold shock proteins is predictive for deleterious outcome in various malignant diseases. We recently described active secretion of a family member, denoted Y-box (YB) protein-1...

    Authors: Frank Tacke, Nicolas Kanig, Abdelaziz En-Nia, Thilo Kaehne, Christiane S Eberhardt, Victoria Shpacovitch, Christian Trautwein and Peter R Mertens
    Citation: BMC Cancer 2011 11:185
    Content type: Research article Published on:

  31. Current diagnostic tools for prostate cancer lack specificity and sensitivity for detecting very early lesions. DNA methylation is a stable genomic modification that is detectable in peripheral patient fluids ...

    Authors: Marie K. Kirby, Ryne C. Ramaker, Brian S. Roberts, Brittany N. Lasseigne, David S. Gunther, Todd C. Burwell, Nicholas S. Davis, Zulfiqar G. Gulzar, Devin M. Absher, Sara J. Cooper, James D. Brooks and Richard M. Myers
    Citation: BMC Cancer 2017 17:273
    Content type: Research article Published on:

  32. Androgen deprivation therapy is the primary strategy for the treatment of advanced prostate cancer; however, after an initial regression, most patients will inevitably develop a fatal androgen-independent tumo...

    Authors: Xiaolu Wang, Haitao Gao, Lixin Ren, Junfei Gu, Yanping Zhang and Yong Zhang
    Citation: BMC Cancer 2014 14:308
    Content type: Research article Published on:

  33. Modulation of the expression of retinoic acid receptors (RAR) α and γ in adult rat prostate by testosterone (T) suggests that RAR signaling events might mediate some of the androgen effects on prostate cells.

    Authors: Ming-tang Li, Frank Richter, Chawnshang Chang, Robert J Irwin and Hosea FS Huang
    Citation: BMC Cancer 2002 2:16
    Content type: Research article Published on:

  34. Nitrogen-containing bisphosphonates (N-BPs) have been designed to inhibit osteoclast-mediated bone resorption. However, it is now accepted that part of their anti-tumor activities is related to interference wi...

    Authors: M Goffinet, M Thoulouzan, A Pradines, I Lajoie-Mazenc, Carolyn Weinbaum, JC Faye and S Séronie-Vivien
    Citation: BMC Cancer 2006 6:60
    Content type: Research article Published on:

  35. Endonuclease domain containing 1 (ENDOD1) is implicated in tumorigenesis and aggressiveness of multiple tumors. In this study, we aimed to investigate the role of ENDOD1 in prostate cancer (PCa).

    Authors: Jianguang Qiu, Shubin Peng, Jie Si-Tu, Cheng Hu, Wentao Huang, Yunhua Mao, Wenhan Qiu, Ke Li and Dejuan Wang
    Citation: BMC Cancer 2017 17:360
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2017 17:569

  36. Prostate cancer metastasizes to regional lymph nodes and distant sites but the roles of lymphatic and hematogenous pathways in metastasis are not fully understood.

    Authors: Johanna Tuomela, Maija Valta, Jani Seppänen, Kati Tarkkonen, H Kalervo Väänänen and Pirkko Härkönen
    Citation: BMC Cancer 2009 9:362
    Content type: Research article Published on:

  37. Inconsistent associations between smoking status and prostate cancer (PC) could be due to exposure assessment error. Reconstructing smoking behaviors over the life course could reduce exposure assessment error.

    Authors: Evelyn Jiménez-Mendoza, Ruth A. Vázquez-Salas, Tonatiuh Barrientos-Gutierrez, Luz Myriam Reynales-Shigematsu, Isaac Roberto Labra-Salgado, Hugo A. Manzanilla-García and Luisa E. Torres-Sánchez
    Citation: BMC Cancer 2018 18:160
    Content type: Research article Published on:

  38. Non-muscle-invasive bladder cancer (NMIBC) is the most common neoplasm of the urinary tract and requires life-long invasive surveillance to detect disease recurrence. Currently, there are no effective oral the...

    Authors: Remco J. Molenaar, Jons W. van Hattum, Iris S. Brummelhuis, Jorg R. Oddens, C. Dilara Savci-Heijink, Egbert R. Boevé, Saskia A. van der Meer, J. Fred Witjes, Michael N. Pollak, Theo M. de Reijke and Johanna W. Wilmink
    Citation: BMC Cancer 2019 19:1133
    Content type: Study protocol Published on:

  39. The total intake of dietary antioxidants may reduce prostate cancer risk but available data are sparse and the possible role of supplements unclear. We investigated the potential association between total and ...

    Authors: Kjell M. Russnes, Elisabeth Möller, Kathryn M. Wilson, Monica Carlsen, Rune Blomhoff, Sigbjørn Smeland, Hans-Olov Adami, Henrik Grönberg, Lorelei A. Mucci and Katarina Bälter
    Citation: BMC Cancer 2016 16:438
    Content type: Research article Published on:

  40. Advanced non-small cell lung cancer (NSCLC) represents a significant unmet medical need. Despite advances with targeted therapies in a small subset of patients, fewer than 20% of patients survive for more than...

    Authors: Martin Sebastian, Alexandros Papachristofilou, Christian Weiss, Martin Früh, Richard Cathomas, Wolfgang Hilbe, Thomas Wehler, Gerd Rippin, Sven D Koch, Birgit Scheel, Mariola Fotin-Mleczek, Regina Heidenreich, Karl-Josef Kallen, Ulrike Gnad-Vogt and Alfred Zippelius
    Citation: BMC Cancer 2014 14:748
    Content type: Study protocol Published on:

  41. Prostate cancer is characterized by heterogeneity in the clinical course that often does not correlate with morphologic features of the tumor. Metastasis reflects the most adverse outcome of prostate cancer, a...

    Authors: Uma R Chandran, Changqing Ma, Rajiv Dhir, Michelle Bisceglia, Maureen Lyons-Weiler, Wenjing Liang, George Michalopoulos, Michael Becich and Federico A Monzon
    Citation: BMC Cancer 2007 7:64
    Content type: Research article Published on:

  42. Nitric oxide (NO) and its oxidative reaction products have been repeatedly shown to block steroid receptor function via nitrosation of zinc finger structures in the DNA-binding domain (DBD). In consequence NO-...

    Authors: Martin Laschak, Klaus-Dieter Spindler, Andres J Schrader, Andrea Hessenauer, Wolfgang Streicher, Mark Schrader and Marcus V Cronauer
    Citation: BMC Cancer 2012 12:130
    Content type: Research article Published on:

  43. Tumour metastasis remains the major cause of death in cancer patients and, to date, the mechanism and signalling pathways governing this process are not completely understood. The TGF-β pathway is the most com...

    Authors: Jo-Anne de la Mare, Tamarin Jurgens and Adrienne L. Edkins
    Citation: BMC Cancer 2017 17:202
    Content type: Research article Published on:

  44. The imbalance between the action of the tissue inhibitors of matrix metalloproteinases (TIMPs) and the matrix metalloproteinases (MMPs) is one component of metastasis physiology. TIMP-1 overrides MMP-9 activit...

    Authors: Renato F. Ivanovic, Nayara I. Viana, Denis R. Morais, Caio Moura, Iran A. Silva, Katia R. Leite, José Pontes-Junior, William C. Nahas, Miguel Srougi and Sabrina T. Reis
    Citation: BMC Cancer 2018 18:992
    Content type: Research article Published on:

  45. The development of androgen resistance is a major limitation to androgen deprivation treatment in prostate cancer. We have developed an in vitro model of androgen-resistance to characterise molecular changes occu...

    Authors: Sujitra Detchokul, Aparna Elangovan, Edmund J. Crampin, Melissa J. Davis and Albert G. Frauman
    Citation: BMC Cancer 2015 15:883
    Content type: Research article Published on:

  47. Therapeutic targeting of the androgen signaling pathway is a mainstay treatment for prostate cancer. Although initially effective, resistance to androgen targeted therapies develops followed by disease progres...

    Authors: Maxine G. B. Tran, Becky A. S. Bibby, Lingjian Yang, Franklin Lo, Anne Y. Warren, Deepa Shukla, Michelle Osborne, James Hadfield, Thomas Carroll, Rory Stark, Helen Scott, Antonio Ramos-Montoya, Charlie Massie, Patrick Maxwell, Catharine M. L. West, Ian G. Mills…
    Citation: BMC Cancer 2020 20:469
    Content type: Research article Published on:

  48. The Bag (Bcl-2 associated athanogene) family of proteins consists of 6 members sharing a common, single-copied Bag domain through which they interact with the molecular chaperone Hsp70. Bag5 represents an exce...

    Authors: Anja Bruchmann, Corinna Roller, Tamara Vanessa Walther, Georg Schäfer, Sara Lehmusvaara, Tapio Visakorpi, Helmut Klocker, Andrew C B Cato and Danilo Maddalo
    Citation: BMC Cancer 2013 13:96
    Content type: Research article Published on:

  49. Prostate cancer (PCa) is the second most common cancer in men worldwide. The standard non-surgical approach for localized PCa is radiotherapy (RT), but one of the limitations of high-dose RT is the potential i...

    Authors: Patrizia Gnagnarella, Giulia Marvaso, Barbara Alicja Jereczek-Fossa, Ottavio de Cobelli, Maria Claudia Simoncini, Luiz Felipe Nevola Teixeira, Annarita Sabbatini, Gabriella Pravettoni, Harriet Johansson, Luigi Nezi, Paolo Muto, Valentina Borzillo, Egidio Celentano, Anna Crispo, Monica Pinto, Ernesta Cavalcanti…
    Citation: BMC Cancer 2022 22:794
    Content type: Study protocol Published on:

  50. Understanding the complex, multistep process of metastasis remains a major challenge in cancer research. Metastasis models can reveal insights in tumor development and progression and provide tools to test new...

    Authors: Jacqueline Banyard, Ivy Chung, Matthew Migliozzi, Derek T Phan, Arianne M Wilson, Bruce R Zetter and Diane R Bielenberg
    Citation: BMC Cancer 2014 14:387
    Content type: Research article Published on:

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