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  1. Signaling networks promoting cell growth and proliferation are frequently deregulated in cancer. Tumors often are highly dependent on such signaling pathways and may become hypersensitive to downregulation of ...

    Authors: Boris W Kramer, Rudolf Götz and Ulf R Rapp
    Citation: BMC Cancer 2004 4:24
    Content type: Research article Published on:

  2. Therapeutic options to effectively inhibit growth and spread of neuroendocrine gastrointestinal tumors are still limited. As both meta-iodobenzylguanidine (MIBG) and interferon-γ (IFNγ) cause antineoplastic ef...

    Authors: Michael Höpfner, Andreas P Sutter, Alexander Huether, Gudrun Ahnert-Hilger and Hans Scherübl
    Citation: BMC Cancer 2004 4:23
    Content type: Research article Published on:

  3. Patients with cancer must make frequent visits to the clinic not only for chemotherapy but also for the management of treatment-related adverse effects. Neutropenia, the most common dose-limiting toxicity of m...

    Authors: Barry V Fortner, Kurt Tauer, Ling Zhu, Theodore A Okon, Kelley Moore, Davis Templeton and Lee Schwartzberg
    Citation: BMC Cancer 2004 4:22
    Content type: Research article Published on:

  5. DNA microarray profiling performed on clinical tissue specimens can potentially provide significant information regarding human cancer biology. Biopsy cores, the typical source of human tumor tissue, however, ...

    Authors: Elizabeth M Goley, Soni J Anderson, Cynthia Ménard, Eric Chuang, Xing Lü, Philip J Tofilon and Kevin Camphausen
    Citation: BMC Cancer 2004 4:20
    Content type: Research article Published on:

  7. Integrin-extracellular matrix interactions activate signaling cascades such as mitogen activated protein kinases (MAPK). Integrin binding to extracellular matrix increases tyrosine phosphorylation of focal adh...

    Authors: David L Crowe and Arthur Ohannessian
    Citation: BMC Cancer 2004 4:18
    Content type: Research article Published on:

  11. Surveillance colonoscopy is commonly recommended following potentially curative surgery for colorectal cancer. We determined factors associated with patients undergoing a least one colonoscopy within five year...

    Authors: Robert J Hilsden, Heather E Bryant, Lloyd R Sutherland, Penny MA Brasher and Anthony LA Fields
    Citation: BMC Cancer 2004 4:14
    Content type: Research article Published on:

  13. Most of the steps involved in the initiation and progression of Hürthle (oncocytic, oxyphilic) cell carcinomas of the thyroid remain unknown.

    Authors: Valdemar Máximo, Ana Preto, Ana Crespo, Ana Sofia Rocha, José Carlos Machado, Paula Soares and Manuel Sobrinho-Simões
    Citation: BMC Cancer 2004 4:12
    Content type: Research article Published on:

  14. Fluoropyrimidines such as 5-fluorouracil (5-FU) and 5-fluoro-2'deoxyuridine (FUDR) are among the most effective chemotherapeutic agents for treatment of metastatic colorectal cancer (CRC). Increased expression...

    Authors: Massimo Libra, Patrick M Navolanic, Renato Talamini, Erica Cecchin, Franca Sartor, Salvatore Tumolo, Sara Masier, Salvatore Travali, Mauro Boiocchi and Giuseppe Toffoli
    Citation: BMC Cancer 2004 4:11
    Content type: Research article Published on:

  16. Subtle functional deficiencies in highly conserved DNA repair or growth regulatory processes resulting from polymorphic variation may increase genetic susceptibility to breast cancer. Polymorphisms in DNA repa...

    Authors: Alice J Sigurdson, Michael Hauptmann, Nilanjan Chatterjee, Bruce H Alexander, Michele Morin Doody, Joni L Rutter and Jeffery P Struewing
    Citation: BMC Cancer 2004 4:9
    Content type: Research article Published on:

  20. Carcinoma of uterine cervix is the second most common cancers among women worldwide. Combined radiation and chemotherapy is the choice of treatment for advanced stages of the disease. The prognosis is poor, wi...

    Authors: Pulivarthi H Rao, Hugo Arias-Pulido, Xin-Yan Lu, Charles P Harris, Hernan Vargas, Fang F Zhang, Gopeshwar Narayan, Achim Schneider, Mary Beth Terry and Vundavalli VVS Murty
    Citation: BMC Cancer 2004 4:5
    Content type: Research article Published on:

  21. Carcinogenesis occurs, at least in part, due to the accumulation of mutations in critical genes that control the mechanisms of cell proliferation, differentiation and death. Publicly accessible databases conta...

    Authors: Ping Qiu, Luquan Wang, Mitch Kostich, Wei Ding, Jason S Simon and Jonathan R Greene
    Citation: BMC Cancer 2004 4:4
    Content type: Research article Published on:

  22. A case of Primitive Neuroectodermal Tumor (PNET) of the kidney in a 27-year-old woman is presented. Few cases are reported in the literature with a variable, nonspecific presentation and an aggressive behaviou...

    Authors: Giorgio Pomara, Francesco Cappello, Maria G Cuttano, Francesca Rappa, Girolamo Morelli, Pierantonio Mancini and Cesare Selli
    Citation: BMC Cancer 2004 4:3
    Content type: Case report Published on:

  23. Although sentinel node biopsy (SNB) is becoming the standard approach for axillary staging in patients with small breast cancer, criteria for patient selection and some technical aspects of the procedure have ...

    Authors: Giorgio Zavagno, Gian Luca De Salvo, Dario Casara, Paola Del Bianco, Domenico Rubello, Fabrizio Meggiolaro, Carlo Riccardo Rossi, Mariaelena Pierobon and Mario Lise
    Citation: BMC Cancer 2004 4:2
    Content type: Research article Published on:

  24. Kaposi's sarcoma (KS) is a mesenchymal tumour associated with human herpesvirus-8 infection. However, the incidence of human herpesvirus-8 infection is far higher than the prevalence of KS, suggesting that vir...

    Authors: Thierry Simonart
    Citation: BMC Cancer 2004 4:1
    Content type: Debate Published on:

  25. Dysregulation of apoptosis, specifically overexpression of soluble Fas (sFas), has been proposed to play a role in the development of ovarian cancer. The main objective of the present study was to evaluate ser...

    Authors: Arslan Akhmedkhanov, Eva Lundin, Seth Guller, Annekatrin Lukanova, Andrea Micheli, Yuehong Ma, Yelena Afanasyeva, Anne Zeleniuch-Jacquotte, Vittorio Krogh, Per Lenner, Paola Muti, Sabina Rinaldi, Rudolf Kaaks, Franco Berrino, Göran Hallmans and Paolo Toniolo
    Citation: BMC Cancer 2003 3:33
    Content type: Research article Published on:

  26. Patients with advanced (incurable) tumours usually experience a diverse burden of symptoms. Although many symptom assessment instruments are available, we examined whether these addressed tumour-related symptoms.

    Authors: Margherita J Barresi, Bruce Shadbolt, Don Byrne and Robin Stuart-Harris
    Citation: BMC Cancer 2003 3:32
    Content type: Research article Published on:

  27. Renal cell carcinoma is a common malignancy that often presents as a metastatic-disease for which there are no effective treatments. To gain insights into the mechanism of renal cell carcinogenesis, a number o...

    Authors: Marc E Lenburg, Louis S Liou, Norman P Gerry, Garrett M Frampton, Herbert T Cohen and Michael F Christman
    Citation: BMC Cancer 2003 3:31
    Content type: Research article Published on:

  29. The p53 tumor suppressor gene is commonly mutated in colorectal cancer. While the effect of p53 mutations on colorectal cancer prognosis has been heavily studied, less is known about how epidemiologic risk factor...

    Authors: Mary Beth Terry, Alfred I Neugut, Mahesh Mansukhani, Jerome Waye, Noam Harpaz and Hanina Hibshoosh
    Citation: BMC Cancer 2003 3:29
    Content type: Research article Published on:

  30. Observational studies have consistently shown that aspirin and non-steroidal anti-inflammatory drug (NSAID) use is associated with a close to 50% reduced risk of colorectal cancer. Studies assessing the effect...

    Authors: Antonio González-Pérez, Luis A García Rodríguez and Ruy López-Ridaura
    Citation: BMC Cancer 2003 3:28
    Content type: Research article Published on:

  31. Morphologic criteria which might help to support the need for a preventive strategy for early detection of rectal cancer were analysed. Population-based data on rectal adenomas with high-grade dysplastic chang...

    Authors: René Scheiden, Julien Sand, Joseph Weber, Philippe Turk, Yolande Wagener and Catherine Capesius
    Citation: BMC Cancer 2003 3:27
    Content type: Technical advance Published on:

  32. A systematic review was conducted to evaluate the literature regarding the impact of follow-up on colorectal cancer patient survival and, in a second phase, recommendations were developed.

    Authors: Alvaro Figueredo, R Bryan Rumble, Jean Maroun, Craig C Earle, Bernard Cummings, Robin McLeod, Lisa Zuraw and Caroline Zwaal
    Citation: BMC Cancer 2003 3:26
    Content type: Research article Published on:

  33. Tocopherols are lipid soluble antioxidants that exist as eight structurally different isoforms. The intake of γ-tocopherol is higher than α-tocopherol in the average US diet. The clinical results of the effect...

    Authors: Sharon E Campbell, William L Stone, Sarah G Whaley, Min Qui and Koyamangalath Krishnan
    Citation: BMC Cancer 2003 3:25
    Content type: Research article Published on:

  36. Estrogen signaling plays a critical role in a number of normal physiological processes and has important implications in the treatment of breast cancer. The p160 nuclear receptor coactivator, AIB1 (amplified in b...

    Authors: Sarah L Anzick, David O Azorsa, S Stoney Simons Jr and Paul S Meltzer
    Citation: BMC Cancer 2003 3:22
    Content type: Research article Published on:

  39. We wished to evaluate the clinical response following ATP-Tumor Chemosensitivity Assay (ATP-TCA) directed salvage chemotherapy in a series of UK patients with advanced ovarian cancer. The results are compared ...

    Authors: Sanjay Sharma, Michael H Neale, Federica Di Nicolantonio, Louise A Knight, Pauline A Whitehouse, Stuart J Mercer, Bernard R Higgins, Alan Lamont, Richard Osborne, Andrew C Hindley, Christian M Kurbacher and Ian A Cree
    Citation: BMC Cancer 2003 3:19
    Content type: Research article Published on:

  40. Breast and cervical cancer continue to represent major health challenges for African American women. among Caucasian women. The underlying reasons for this disparity are multifactorial and include lack of educ...

    Authors: Thelma C Hurd, Paola Muti, Deborah O Erwin and Sharita Womack
    Citation: BMC Cancer 2003 3:18
    Content type: Research article Published on:

  42. To determine whether the dose-volume histograms (DVH's) for the rectum and bladder constructed using biological-effective dose (BED-DVH's) better correlate with late gastrointestinal (GI) and genitourinary (GU...

    Authors: Ashesh B Jani, Christopher M Hand, Charles A Pelizzari, John C Roeske, Lani Krauz and Srinivasan Vijayakumar
    Citation: BMC Cancer 2003 3:16
    Content type: Research article Published on:

  43. MART-1, Melan-A, and Tyrosinase have shown encouraging results for evaluation of melanoma micrometastases in sentinel lymph nodes, as compared to conventionally used S-100 protein and HMB-45. To achieve higher...

    Authors: Vinod B Shidham, Dan Qi, R Nagarjun Rao, Scott M Acker, Chung-Che Chang, Bal Kampalath, Glen Dawson, Jinobya K Machhi and Richard A Komorowski
    Citation: BMC Cancer 2003 3:15
    Content type: Research article Published on:

  44. This study assesses whether comparatively high prostate cancer incidence rates among white men in Utah represent higher rates among members of the Church of Jesus Christ of Latter-day Saints (LDS or Mormons), ...

    Authors: Ray M Merrill, Sterling C Hilton, Charles L Wiggins and Jared D Sturgeon
    Citation: BMC Cancer 2003 3:14
    Content type: Research article Published on:

  45. Both phenotypic and cytogenetic variability have been reported for clones of breast carcinoma cell lines but have not been comprehensively studied. Despite this, cell lines such as MCF-7 cells are extensively ...

    Authors: Mélanie Nugoli, Paul Chuchana, Julie Vendrell, Béatrice Orsetti, Lisa Ursule, Catherine Nguyen, Daniel Birnbaum, Emmanuel JP Douzery, Pascale Cohen and Charles Theillet
    Citation: BMC Cancer 2003 3:13
    Content type: Research article Published on:

  46. The evaluation of cancer patients needs, especially during that delicate period when they are hospitalized, allows the identification of those areas of care that require to be improved. Aims of the study were ...

    Authors: Marcello Tamburini, Laura Gangeri, Cinzia Brunelli, Paolo Boeri, Claudia Borreani, Marco Bosisio, Claude Fusco Karmann, Margherita Greco, Guido Miccinesi, Luciana Murru and Patrizia Trimigno
    Citation: BMC Cancer 2003 3:12
    Content type: Research article Published on:

  49. Recent observations indicate that human tumorous breast tissue metabolizes progesterone differently than nontumorous breast tissue. Specifically, 5α-reduced metabolites (5α-pregnanes, shown to stimulate cell p...

    Authors: John P Wiebe and Michael J Lewis
    Citation: BMC Cancer 2003 3:9
    Content type: Research article Published on:

  50. Uterine cervix carcinoma is the second most common female malignancy worldwide and a major health problem in Mexico, representing the primary cause of death among the Mexican female population. High risk human...

    Authors: Alfredo Hidalgo, Alberto Monroy, Rosa Ma Arana, Lucía Taja, Guelaguetza Vázquez and Mauricio Salcedo
    Citation: BMC Cancer 2003 3:8
    Content type: Research article Published on:

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