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  1. Renal cell carcinoma is a common malignancy that often presents as a metastatic-disease for which there are no effective treatments. To gain insights into the mechanism of renal cell carcinogenesis, a number o...

    Authors: Marc E Lenburg, Louis S Liou, Norman P Gerry, Garrett M Frampton, Herbert T Cohen and Michael F Christman
    Citation: BMC Cancer 2003 3:31
    Content type: Research article Published on:

  3. The p53 tumor suppressor gene is commonly mutated in colorectal cancer. While the effect of p53 mutations on colorectal cancer prognosis has been heavily studied, less is known about how epidemiologic risk factor...

    Authors: Mary Beth Terry, Alfred I Neugut, Mahesh Mansukhani, Jerome Waye, Noam Harpaz and Hanina Hibshoosh
    Citation: BMC Cancer 2003 3:29
    Content type: Research article Published on:

  4. Observational studies have consistently shown that aspirin and non-steroidal anti-inflammatory drug (NSAID) use is associated with a close to 50% reduced risk of colorectal cancer. Studies assessing the effect...

    Authors: Antonio González-Pérez, Luis A García Rodríguez and Ruy López-Ridaura
    Citation: BMC Cancer 2003 3:28
    Content type: Research article Published on:

  5. Morphologic criteria which might help to support the need for a preventive strategy for early detection of rectal cancer were analysed. Population-based data on rectal adenomas with high-grade dysplastic chang...

    Authors: René Scheiden, Julien Sand, Joseph Weber, Philippe Turk, Yolande Wagener and Catherine Capesius
    Citation: BMC Cancer 2003 3:27
    Content type: Technical advance Published on:

  6. A systematic review was conducted to evaluate the literature regarding the impact of follow-up on colorectal cancer patient survival and, in a second phase, recommendations were developed.

    Authors: Alvaro Figueredo, R Bryan Rumble, Jean Maroun, Craig C Earle, Bernard Cummings, Robin McLeod, Lisa Zuraw and Caroline Zwaal
    Citation: BMC Cancer 2003 3:26
    Content type: Research article Published on:

  7. Tocopherols are lipid soluble antioxidants that exist as eight structurally different isoforms. The intake of γ-tocopherol is higher than α-tocopherol in the average US diet. The clinical results of the effect...

    Authors: Sharon E Campbell, William L Stone, Sarah G Whaley, Min Qui and Koyamangalath Krishnan
    Citation: BMC Cancer 2003 3:25
    Content type: Research article Published on:

  10. Estrogen signaling plays a critical role in a number of normal physiological processes and has important implications in the treatment of breast cancer. The p160 nuclear receptor coactivator, AIB1 (amplified in b...

    Authors: Sarah L Anzick, David O Azorsa, S Stoney Simons Jr and Paul S Meltzer
    Citation: BMC Cancer 2003 3:22
    Content type: Research article Published on:

  13. We wished to evaluate the clinical response following ATP-Tumor Chemosensitivity Assay (ATP-TCA) directed salvage chemotherapy in a series of UK patients with advanced ovarian cancer. The results are compared ...

    Authors: Sanjay Sharma, Michael H Neale, Federica Di Nicolantonio, Louise A Knight, Pauline A Whitehouse, Stuart J Mercer, Bernard R Higgins, Alan Lamont, Richard Osborne, Andrew C Hindley, Christian M Kurbacher and Ian A Cree
    Citation: BMC Cancer 2003 3:19
    Content type: Research article Published on:

  14. Breast and cervical cancer continue to represent major health challenges for African American women. among Caucasian women. The underlying reasons for this disparity are multifactorial and include lack of educ...

    Authors: Thelma C Hurd, Paola Muti, Deborah O Erwin and Sharita Womack
    Citation: BMC Cancer 2003 3:18
    Content type: Research article Published on:

  16. To determine whether the dose-volume histograms (DVH's) for the rectum and bladder constructed using biological-effective dose (BED-DVH's) better correlate with late gastrointestinal (GI) and genitourinary (GU...

    Authors: Ashesh B Jani, Christopher M Hand, Charles A Pelizzari, John C Roeske, Lani Krauz and Srinivasan Vijayakumar
    Citation: BMC Cancer 2003 3:16
    Content type: Research article Published on:

  17. MART-1, Melan-A, and Tyrosinase have shown encouraging results for evaluation of melanoma micrometastases in sentinel lymph nodes, as compared to conventionally used S-100 protein and HMB-45. To achieve higher...

    Authors: Vinod B Shidham, Dan Qi, R Nagarjun Rao, Scott M Acker, Chung-Che Chang, Bal Kampalath, Glen Dawson, Jinobya K Machhi and Richard A Komorowski
    Citation: BMC Cancer 2003 3:15
    Content type: Research article Published on:

  18. This study assesses whether comparatively high prostate cancer incidence rates among white men in Utah represent higher rates among members of the Church of Jesus Christ of Latter-day Saints (LDS or Mormons), ...

    Authors: Ray M Merrill, Sterling C Hilton, Charles L Wiggins and Jared D Sturgeon
    Citation: BMC Cancer 2003 3:14
    Content type: Research article Published on:

  19. Both phenotypic and cytogenetic variability have been reported for clones of breast carcinoma cell lines but have not been comprehensively studied. Despite this, cell lines such as MCF-7 cells are extensively ...

    Authors: Mélanie Nugoli, Paul Chuchana, Julie Vendrell, Béatrice Orsetti, Lisa Ursule, Catherine Nguyen, Daniel Birnbaum, Emmanuel JP Douzery, Pascale Cohen and Charles Theillet
    Citation: BMC Cancer 2003 3:13
    Content type: Research article Published on:

  20. The evaluation of cancer patients needs, especially during that delicate period when they are hospitalized, allows the identification of those areas of care that require to be improved. Aims of the study were ...

    Authors: Marcello Tamburini, Laura Gangeri, Cinzia Brunelli, Paolo Boeri, Claudia Borreani, Marco Bosisio, Claude Fusco Karmann, Margherita Greco, Guido Miccinesi, Luciana Murru and Patrizia Trimigno
    Citation: BMC Cancer 2003 3:12
    Content type: Research article Published on:

  23. Recent observations indicate that human tumorous breast tissue metabolizes progesterone differently than nontumorous breast tissue. Specifically, 5α-reduced metabolites (5α-pregnanes, shown to stimulate cell p...

    Authors: John P Wiebe and Michael J Lewis
    Citation: BMC Cancer 2003 3:9
    Content type: Research article Published on:

  24. Uterine cervix carcinoma is the second most common female malignancy worldwide and a major health problem in Mexico, representing the primary cause of death among the Mexican female population. High risk human...

    Authors: Alfredo Hidalgo, Alberto Monroy, Rosa Ma Arana, Lucía Taja, Guelaguetza Vázquez and Mauricio Salcedo
    Citation: BMC Cancer 2003 3:8
    Content type: Research article Published on:

  25. Kaposi's Sarcoma (KS) is a proliferation of aberrant vascular structures lined by spindle cells, and is caused by a gammaherpes virus (HHV8/KSHV). Its course is aggravated by co-infection with HIV-1, where the...

    Authors: Marion Cornelissen, Antoinette C van der Kuyl, Remco van den Burg, Fokla Zorgdrager, Carel JM van Noesel and Jaap Goudsmit
    Citation: BMC Cancer 2003 3:7
    Content type: Research article Published on:

  26. RAD54L (OMIM 603615, Locus Link 8438) has been proposed as a candidate oncosupressor in tumours bearing a non-random deletion of 1p32, such as breast or colon carcinomas, lymphomas and meningiomas. In a search f...

    Authors: Paola E Leone, Marta Mendiola, Javier Alonso, César Paz-y-Miño and Angel Pestaña
    Citation: BMC Cancer 2003 3:6
    Content type: Research article Published on:

  27. Although colorectal cancer death rates have been declining, this trend is not consistent across all ethnic groups. Biological, environmental, behavioral and socioeconomic explanations exist, but the reason for...

    Authors: Ian S Pagano, Shane Y Morita, Sanjaya Dhakal, Scott A Hundahl and Gertraud Maskarinec
    Citation: BMC Cancer 2003 3:5
    Content type: Research article Published on:

  28. The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) encodes for a multifunctional receptor involved in lysosomal enzyme trafficking, fetal organogenesis, cytotoxic T cell-induced apoptosis a...

    Authors: Timothy A Jamieson, David M Brizel, J Keith Killian, Yoshihiko Oka, Hong-Seok Jang, Xiaolong Fu, Robert W Clough, Robin T Vollmer, Mitchell S Anscher and Randy L Jirtle
    Citation: BMC Cancer 2003 3:4
    Content type: Research article Published on:

  29. Microarray-based gene expression profiling is a powerful approach for the identification of molecular biomarkers of disease, particularly in human cancers. Utility of this approach to measure responses to ther...

    Authors: Samuel E DePrimo, Lily M Wong, Deepak B Khatry, Susan L Nicholas, William C Manning, Beverly D Smolich, Anne-Marie O'Farrell and Julie M Cherrington
    Citation: BMC Cancer 2003 3:3
    Content type: Research article Published on:

  30. Many tumours undergo disregulation of polyamine homeostasis and upregulation of ornithine decarboxylase (ODC) activity, which can promote carcinogenesis. In animal models of colon carcinogenesis, inhibition of...

    Authors: E Ann Hudson, Lynne M Howells, Barbara Gallacher-Horley, Louise H Fox, Andreas Gescher and Margaret M Manson
    Citation: BMC Cancer 2003 3:2
    Content type: Research article Published on:

  31. Although new endoscopic techniques can enhance the ability to detect a suspicious lung lesion, the primary diagnosis still depends on subjective visual assessment. We evaluated whether thermal heterogeneity of...

    Authors: Christodoulos Stefanadis, Christina Chrysohoou, Demosthenes B Panagiotakos, Elisabeth Passalidou, Vasiliki Katsi, Vlassios Polychronopoulos and Pavlos K Toutouzas
    Citation: BMC Cancer 2003 3:1
    Content type: Research article Published on:

  32. Mortality estimates alone are not sufficient to understand the true magnitude of cancer burden. We present the detailed estimates of mortality and incidence by site as the basis for the future estimation of ca...

    Authors: Kenji Shibuya, Colin D Mathers, Cynthia Boschi-Pinto, Alan D Lopez and Christopher JL Murray
    Citation: BMC Cancer 2002 2:37
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2003 3:20

  33. The Global Burden of Disease 2000 (GBD 2000) study starts from an analysis of the overall mortality envelope in order to ensure that the cause-specific estimates add to the total all cause mortality by age and...

    Authors: Colin D Mathers, Kenji Shibuya, Cynthia Boschi-Pinto, Alan D Lopez and Christopher JL Murray
    Citation: BMC Cancer 2002 2:36
    Content type: Research article Published on:

  34. Sodium/iodide symporter (NIS) is a key protein in iodide transport by thyroid cells and this activity is a prerequisite for effective radioiodide treatment of thyroid cancer. In the majority of thyroid cancers...

    Authors: Eusebio Chiefari, Antonio Brunetti, Franco Arturi, Jean-Michel Bidart, Diego Russo, Martin Schlumberger and Sebastiano Filetti
    Citation: BMC Cancer 2002 2:35
    Content type: Research article Published on:

  35. A number of osteoblastic meningiomas, primary osteosarcomas of the meninges, and post-radiation osteosarcomas of the head have been reported. However, postradiation dedifferentiation of meningioma into osteosa...

    Authors: Vladimir Osipov, Khang-Che Ho, Hendrikus G Krouwer, Glenn Meyer and Vinod B Shidham
    Citation: BMC Cancer 2002 2:34
    Content type: Case report Published on:

  36. Medulloblastomas, embryonal tumors arising in the cerebellum, commonly contain mutations that activate Wnt signaling. To determine whether increased Wnt signaling in the adult CNS is sufficient to induce tumor...

    Authors: John E Kratz, Duncan Stearns, David L Huso, Hilda H Slunt, Donald L Price, David R Borchelt and Charles G Eberhart
    Citation: BMC Cancer 2002 2:33
    Content type: Research article Published on:

  37. The activity of the ribonucleoprotein enzyme telomerase is detectable in germ, stem and tumor cells. One major component of telomerase is human telomerase reverse transcriptase (hTERT), which encodes the catal...

    Authors: Mark Schrader, Angelika M Burger, Markus Müller, Hans Krause, Bernd Straub, Martin Schostak, Wolfgang Schulze, Heidrun Lauke and Kurt Miller
    Citation: BMC Cancer 2002 2:32
    Content type: Research article Published on:

  38. Although a large number of epidemiological studies have examined the role of aspirin in the chemoprevention of colon cancer and other solid tumors, there is a limited body of research focusing on the associati...

    Authors: Kirsten B Moysich, Ravi J Menezes, Adrienne Ronsani, Helen Swede, Mary E Reid, K Michael Cummings, Karen L Falkner, Gregory M Loewen and Gerold Bepler
    Citation: BMC Cancer 2002 2:31
    Content type: Research article Published on:

  40. Hepatocellular carcinoma (HCC) presents one of the major health threats in China today. A better understanding of the molecular genetics underlying malignant transformation of hepatocytes is critical to succes...

    Authors: Jian Yu, Min Ni, Jian Xu, Hongyu Zhang, Baomei Gao, Jianren Gu, Jianguo Chen, Lisheng Zhang, Mengchao Wu, Sushen Zhen and Jingde Zhu
    Citation: BMC Cancer 2002 2:29
    Content type: Research article Published on:

  41. Psoriasin has been identified as a gene that is highly expressed in pre-invasive breast cancer, but is often downregulated with breast cancer progression. It is currently unknown whether psoriasin influences e...

    Authors: Ethan D Emberley, R Daniel Gietz, J Darren Campbell, Kent T HayGlass, Leigh C Murphy and Peter H Watson
    Citation: BMC Cancer 2002 2:28
    Content type: Research article Published on:

  45. In cervical tumours the integration of human papilloma viruses (HPV) transcripts often results in the generation of transcripts that consist of hybrids of viral and cellular sequences. Mapping data using a var...

    Authors: Eugene Klimov, Svetlana Vinokourova, Elena Moisjak, Elian Rakhmanaliev, Vera Kobseva, Laimonis Laimins, Fjodor Kisseljov and Galina Sulimova
    Citation: BMC Cancer 2002 2:24
    Content type: Research article Published on:

  46. This study was designed to evaluate if erythropoietin (EPO) is effective in the treatment of cancer related anemia, and if its effect remains unchanged when data are analyzed according to various clinical and ...

    Authors: Otavio Clark, Jared R Adams, Charles L Bennett and Benjamin Djulbegovic
    Citation: BMC Cancer 2002 2:23
    Content type: Research article Published on:

  48. Drugs & used in anticancer chemotherapy have severe effects upon the cellular transcription and replication machinery. From in vitro studies it has become clear that these drugs can affect specific genes, as well...

    Authors: Antoinette C van der Kuyl, Remco van den Burg, Fokla Zorgdrager, John T Dekker, Jolanda Maas, Carel JM van Noesel, Jaap Goudsmit and Marion Cornelissen
    Citation: BMC Cancer 2002 2:21
    Content type: Research article Published on:

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