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  1. Prostate cancer is characterized by heterogeneity in the clinical course that often does not correlate with morphologic features of the tumor. Metastasis reflects the most adverse outcome of prostate cancer, a...

    Authors: Uma R Chandran, Changqing Ma, Rajiv Dhir, Michelle Bisceglia, Maureen Lyons-Weiler, Wenjing Liang, George Michalopoulos, Michael Becich and Federico A Monzon
    Citation: BMC Cancer 2007 7:64
    Content type: Research article Published on:

  2. This study evaluated the feasibility, toxicity, response rate and survival of neoadjuvant superselective intra-arterial infusion of high dose carboplatin in advanced head and neck cancer.

    Authors: Giulia Bertino, Marco Benazzo, Patrizia Gatti, Gianni Bernardo, Franco Corbella, Carmine Tinelli, Federico Zappoli and Eugenio Mira
    Citation: BMC Cancer 2007 7:62
    Content type: Research article Published on:

  3. Breast cancer is a heterogeneous disease, presenting with a wide range of histologic, clinical, and genetic features. Microarray technology has shown promise in predicting outcome in these patients.

    Authors: James E Korkola, Ekaterina Blaveri, Sandy DeVries, Dan H Moore II, E Shelley Hwang, Yunn-Yi Chen, Anne LH Estep, Karen L Chew, Ronald H Jensen and Frederic M Waldman
    Citation: BMC Cancer 2007 7:61
    Content type: Research article Published on:

  4. The sex hormone-binding globulin (SHBG) is a carrier protein that modulates the bio-availability of serum sex steroid hormones, which may be involved in ovarian cancer. We evaluated whether common genetic variati...

    Authors: Montserrat Garcia-Closas, Louise A Brinton, Jolanta Lissowska, Douglas Richesson, Mark E Sherman, Neonila Szeszenia-Dabrowska, Beata Peplonska, Robert Welch, Meredith Yeager, Witold Zatonski and Stephen J Chanock
    Citation: BMC Cancer 2007 7:60
    Content type: Research article Published on:

  5. Signaling pathways that converge on two different transcription factor complexes, NFκB and AP-1, have been identified in estrogen receptor (ER)-positive breast cancers resistant to the antiestrogen, tamoxifen.

    Authors: Yamei Zhou, Christina Yau, Joe W Gray, Karen Chew, Shanaz H Dairkee, Dan H Moore, Urs Eppenberger, Serenella Eppenberger-Castori and Christopher C Benz
    Citation: BMC Cancer 2007 7:59
    Content type: Research article Published on:

  6. The identification of genomic signatures of colorectal cancer for risk stratification requires the study of large series of cancer patients with an extensive clinical follow-up. Multicentric clinical studies r...

    Authors: Heiko Fensterer, Bernhard Radlwimmer, Jörn Sträter, Malte Buchholz, Daniela E Aust, Catherine Julié, François Radvanyi, Bernard Nordlinger, Claudio Belluco, Eric Van Cutsem, Claus-Henning Köhne, Hans A Kestler, Carsten Schwaenen, Michelle Nessling, Manfred P Lutz, Peter Lichter…
    Citation: BMC Cancer 2007 7:58
    Content type: Research article Published on:

  7. Bladder cancer is the fourth most frequent malignancy among Uruguayan men. A previous study from Uruguay suggested a high risk of bladder cancer associated with maté drinking. We conducted an additional case-cont...

    Authors: Eduardo De Stefani, Paolo Boffetta, Hugo Deneo-Pellegrini, Pelayo Correa, Alvaro L Ronco, Paul Brennan, Gilles Ferro, Giselle Acosta and María Mendilaharsu
    Citation: BMC Cancer 2007 7:57
    Content type: Research article Published on:

  9. Invasive ductal and lobular carcinomas (IDC and ILC) are the most common histological types of breast cancer. Clinical follow-up data and metastatic patterns suggest that the development and progression of the...

    Authors: Gulisa Turashvili, Jan Bouchal, Karl Baumforth, Wenbin Wei, Marta Dziechciarkova, Jiri Ehrmann, Jiri Klein, Eduard Fridman, Jozef Skarda, Josef Srovnal, Marian Hajduch, Paul Murray and Zdenek Kolar
    Citation: BMC Cancer 2007 7:55
    Content type: Research article Published on:

  10. Epidemiological observations suggest that cancer arises from chronically inflamed tissues. Inflammatory bowel disease (IBD) is a typical example as patients with longstanding IBD are at an increased risk for d...

    Authors: Peter Laszlo Lakatos, Erika Hitre, Ferenc Szalay, Kerstin Zinober, Peter Fuszek, Laszlo Lakatos, Simon Fischer, Janos Osztovits, Orsolya Gemela, Gabor Veres, Janos Papp and Peter Ferenci
    Citation: BMC Cancer 2007 7:54
    Content type: Research article Published on:

  11. Brain metastases (BM) are the most common form of intracranial cancer. The incidence of BM seems to have increased over the past decade. Recursive partitioning analysis (RPA) of data from three Radiation Thera...

    Authors: Gustavo A Viani, Marcus S Castilho, João V Salvajoli, Antonio Cassio A Pellizzon, Paulo E Novaes, Flavio S Guimarães, Maria A Conte and Ricardo C Fogaroli
    Citation: BMC Cancer 2007 7:53
    Content type: Research article Published on:

  12. XIAP-associated factor 1 (XAF1) is a putative tumor suppressor that exerts its proapoptotic effects through both caspase-dependent and – independent means. Loss of XAF1 expression through promoter methylation ...

    Authors: O Cristina Micali, Herman H Cheung, Stéphanie Plenchette, Sandra L Hurley, Peter Liston, Eric C LaCasse and Robert G Korneluk
    Citation: BMC Cancer 2007 7:52
    Content type: Research article Published on:

  13. Gefitinib, an oral agent of epidermal growth factor receptor tyrosine kinase inhibitor, has a certain efficacy against non-small cell lung cancer (NSCLC). Several predictive factors of gefitinib sensitivity ha...

    Authors: Hiroshi Yokouchi, Koichi Yamazaki, Ichiro Kinoshita, Jun Konishi, Hajime Asahina, Noriaki Sukoh, Masao Harada, Kenji Akie, Shigeaki Ogura, Takashi Ishida, Mitsuru Munakata, Hirotoshi Dosaka-Akita, Hiroshi Isobe and Masaharu Nishimura
    Citation: BMC Cancer 2007 7:51
    Content type: Research article Published on:

  14. After two studies reporting response rates higher than 70% in HER2-positive metastatic breast cancer with weekly trastuzumab and vinorelbine, we planned a phase 2 study to test activity of the same combination...

    Authors: Ermelinda De Maio, Carmen Pacilio, Adriano Gravina, Alessandro Morabito, Francesca Di Rella, Vincenzo Labonia, Gabriella Landi, Francesco Nuzzo, Emanuela Rossi, Pasqualina Silvestro, Gerardo Botti, Maurizio Di Bonito, Maria Pia Curcio, Franca Formichelli, Franca La Vecchia, Maria Staiano…
    Citation: BMC Cancer 2007 7:50
    Content type: Research article Published on:

  15. As chondrosarcomas are resistant to chemotherapy and ionizing radiation, therapeutic options are limited. Radical surgery often cannot be performed. Therefore, additional therapies such as antiangiogenesis rep...

    Authors: Frank M Klenke, Amir Abdollahi, Elisabeth Bertl, Martha-Maria Gebhard, Volker Ewerbeck, Peter E Huber and Axel Sckell
    Citation: BMC Cancer 2007 7:49
    Content type: Research article Published on:

  16. Lung cancer (LC) is the leading cause of cancer-related deaths. Oxidative DNA damage may contribute to the cancer risk. The antioxidant paraoxonase (PON1) is an endogenous free radical scavenger in the human b...

    Authors: Emin T Elkiran, Nefsal Mar, Bilge Aygen, Ferit Gursu, Aziz Karaoglu and Suleyman Koca
    Citation: BMC Cancer 2007 7:48
    Content type: Research article Published on:

  17. High risk type human papilloma viruses (HR-HPV) induce carcinomas of the uterine cervix by expressing viral oncogenes E6 and E7. Oncogene E7 of HR-HPV disrupts the pRb/E2F interaction, which negatively regulat...

    Authors: Tatiana A Ivanova, Daria A Golovina, Larisa E Zavalishina, Galina M Volgareva, Alexey N Katargin, Yulia Y Andreeva, Georgy A Frank, Fjodor L Kisseljov and Natalia P Kisseljova
    Citation: BMC Cancer 2007 7:47
    Content type: Research article Published on:

  19. IL-1beta has been implicated in inflammatory episode. In view of the inflammatory nature of cancer cachexia, we determined the predictive value of IL-1B-31 T/C, -511 C/T, +3954 C/T and IL-1RN VNTR gene polymor...

    Authors: Dianliang Zhang, Hongmei Zheng, Yanbing Zhou, Xingming Tang, Baojun Yu and Jieshou Li
    Citation: BMC Cancer 2007 7:45
    Content type: Research article Published on:

  20. Breast cancer is one of the most extensively studied cancers and its genetic basis is well established. Dermatoglyphic traits are formed under genetic control early in development but may be affected by enviro...

    Authors: Chintamani, Rohan Khandelwal, Aliza Mittal, Sai Saijanani, Amita Tuteja, Anju Bansal, Dinesh Bhatnagar and Sunita Saxena
    Citation: BMC Cancer 2007 7:44
    Content type: Research article Published on:

  22. Cancer-cachexia induces a variety of metabolic disorders on protein turnorver, decreasing protein synthesis and increasing protein degradation. Controversly, insulin, other hormones, and branched-chain amino a...

    Authors: Gislaine Ventrucci, Maria Alice R Mello and Maria Cristina C Gomes-Marcondes
    Citation: BMC Cancer 2007 7:42
    Content type: Research article Published on:

  23. The disappointing results of surgical therapy alone of ductal pancreatic cancer can only be improved using multimodal approaches. In contrast to adjuvant therapy, neoadjuvant chemoradiation is able to facilita...

    Authors: Thomas B Brunner, Gerhard G Grabenbauer, Thomas Meyer, Henriette Golcher, Rolf Sauer and Werner Hohenberger
    Citation: BMC Cancer 2007 7:41
    Content type: Study protocol Published on:

  24. The study was designed to investigate immunocompetence in relation to cancer progression in rat and to assess the effect of the traditional Chinese anti-cancer medicine, "Shenyang" prescription, on immunity.

    Authors: Canhua Jiang, Dongxia Ye, Weiliu Qiu, Xiuli Zhang, Zhiyuan Zhang, Di He, Ping Zhang and Wantao Chen
    Citation: BMC Cancer 2007 7:40
    Content type: Research article Published on:

  25. Current histo-pathological prognostic factors are not very helpful in predicting the clinical outcome of breast cancer due to the disease's heterogeneity. Molecular profiling using a large panel of genes could...

    Authors: Maïa Chanrion, Hélène Fontaine, Carmen Rodriguez, Vincent Negre, Frédéric Bibeau, Charles Theillet, Alain Hénaut and Jean-Marie Darbon
    Citation: BMC Cancer 2007 7:39
    Content type: Research article Published on:

  26. Primary small cell carcinoma (SCC) of the esophagus is a rare and aggressive tumor with poor prognosis. In this study, we report the clinicopathological characteristics of 21 cases of small cell carcinoma of t...

    Authors: Jing-Ping Yun, Mei-Fang Zhang, Jin-Hui Hou, Qiu-Hong Tian, Jia Fu, Xiao-Man Liang, Qiu-Liang Wu and Tie-Hua Rong
    Citation: BMC Cancer 2007 7:38
    Content type: Research article Published on:

  27. Shared Pathology Informatics Network (SPIN) is a tissue resource initiative that utilizes clinical reports of the vast amount of paraffin-embedded tissues routinely stored by medical centers. SPIN has an infor...

    Authors: Ashokkumar A Patel, Dilipkumar Gupta, David Seligson, Eyas M Hattab, Ulysses J Balis, Thomas M Ulbright, Isaac S Kohane, Jules J Berman, John R Gilbertson, Sarah Dry, Osvaldo Schirripa, Hong Yu, Michael J Becich and Anil V Parwani
    Citation: BMC Cancer 2007 7:37
    Content type: Research article Published on:

  28. Neoadjuvant chemotherapy has been considered the standard care in locally advanced breast cancer. However, about 20% of the patients do not benefit from this clinical treatment and, predictive factors of respo...

    Authors: Daniel G Tiezzi, Jurandyr M Andrade, Alfredo Ribeiro-Silva, Fábio E Zola, Heitor RC Marana and Marcelo G Tiezzi
    Citation: BMC Cancer 2007 7:36
    Content type: Research article Published on:

  30. The inability of cancer cells to present antigen on the cell surface via MHC class I molecules is one of the mechanisms by which tumor cells evade anti-tumor immunity. Alterations of Jak-STAT components of int...

    Authors: Teresa Rodríguez, Rosa Méndez, Ana Del Campo, Pilar Jiménez, Natalia Aptsiauri, Federico Garrido and Francisco Ruiz-Cabello
    Citation: BMC Cancer 2007 7:34
    Content type: Research article Published on:

  31. Abnormalities in Human Leukocyte Antigen (HLA) class I expression are common in colorectal cancer. Since HLA expression is required to activate tumor antigen-specific cytotoxic T-lymphocytes (CTL), HLA class I...

    Authors: Jan Willem F Dierssen, Noel FCC de Miranda, Soldano Ferrone, Marjo van Puijenbroek, Cees J Cornelisse, Gert Jan Fleuren, Tom van Wezel and Hans Morreau
    Citation: BMC Cancer 2007 7:33
    Content type: Research article Published on:

  33. In general, prognosis and impact of prognostic/predictive factors are assessed with Kaplan-Meier plots and/or the Cox proportional hazard model. There might be substantive differences from the results using th...

    Authors: Patricia Tai, Judith-Anne W Chapman, Edward Yu, Dennie Jones, Changhong Yu, Fei Yuan and Lee Sang-Joon
    Citation: BMC Cancer 2007 7:31
    Content type: Research article Published on:

  35. The STAT (Signal Transducers and Activators of Transcription) transcription factor family mediates cellular responses to a wide range of cytokines. Activated STATs (particularly STAT3) are found in a range of ...

    Authors: James R Matthews, Susan MR Watson, Maxine CL Tevendale, Christine J Watson and Alan R Clarke
    Citation: BMC Cancer 2007 7:29
    Content type: Research article Published on:

  36. Hepatocellular carcinoma is the most common cause of primary liver neoplasms and is one of the main causes of death in patients with liver cirrhosis. High Alpha fetoprotein serum levels have been found in 60–7...

    Authors: Oscar Arrieta, Bernardo Cacho, Daniela Morales-Espinosa, Ana Ruelas-Villavicencio, Diana Flores-Estrada and Norma Hernández-Pedro
    Citation: BMC Cancer 2007 7:28
    Content type: Research article Published on:

  44. Authors: Lucely Cetina, Alicia Garcia-Arias, Maria de Jesus Uribe, Alma Astorga, Myrna Candelaria, Aida Mota, Roque Guadarrama, Lesbia Rivera, Jose Hinojosa and Alfonso Dueñas-Gonzalez
    Citation: BMC Cancer 2007 7(Suppl 1):A17
    Content type: Meeting abstract Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

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