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  1. Gliomas are the most common and aggressive primary brain tumors for which unfortunately no effective treatment modalities exist despite advances in molecular biology as the knowledge base to unravel the extrem...

    Authors: Hua Chen, Qiang Huang, Jun Dong, De-Zhong Zhai, Ai-Dong Wang and Qing Lan
    Citation: BMC Cancer 2008 8:29
    Content type: Research article Published on:

  2. The inter-alpha-trypsin inhibitors (ITI) are a family of plasma protease inhibitors, assembled from a light chain – bikunin, encoded by AMBP – and five homologous heavy chains (encoded by ITIH1, ITIH2, ITIH3, ITI...

    Authors: Alexander Hamm, Juergen Veeck, Nuran Bektas, Peter J Wild, Arndt Hartmann, Uwe Heindrichs, Glen Kristiansen, Tamra Werbowetski-Ogilvie, Rolando Del Maestro, Ruth Knuechel and Edgar Dahl
    Citation: BMC Cancer 2008 8:25
    Content type: Research article Published on:

  3. Patients with advanced cancer suffer from cachexia, which is characterised by a marked weight loss, and is invariably associated with the presence of tumoral and humoral factors which are mainly responsible fo...

    Authors: Claudia L Yano, Gislaine Ventrucci, William N Field, Michael J Tisdale and Maria Cristina C Gomes-Marcondes
    Citation: BMC Cancer 2008 8:24
    Content type: Research article Published on:

  4. Osteosarcoma is the most frequent bone tumor in childhood and adolescence. Patients with primary metastatic disease have a poor prognosis. It is therefore important to better characterize the biology of this t...

    Authors: Irene von Luettichau, Stephan Segerer, Alexandra Wechselberger, Mike Notohamiprodjo, Michaela Nathrath, Markus Kremer, Anna Henger, Roghieh Djafarzadeh, Stefan Burdach, Ralf Huss and Peter J Nelson
    Citation: BMC Cancer 2008 8:23
    Content type: Research article Published on:

  5. Bone tumours are comparatively rare tumours and delays in diagnosis and treatment are common. The purpose of this study was to analyse sociodemographic risk factors for bone tumour patients in order to identif...

    Authors: Christoph Schnurr, Mathias Pippan, Hartmut Stuetzer, Karl S Delank, Joern WP Michael and Peer Eysel
    Citation: BMC Cancer 2008 8:22
    Content type: Research article Published on:

  6. Genetically engineered mouse models of mammary gland cancer enable the in vivo study of molecular mechanisms and signaling during development and cancer pathophysiology. However, traditional whole mount and histo...

    Authors: Maddalena T Tilli, Angela R Parrish, Ion Cotarla, Laundette P Jones, Michael D Johnson and Priscilla A Furth
    Citation: BMC Cancer 2008 8:21
    Content type: Research article Published on:

  7. Quantitative real-time RT-PCR (RT-qPCR) has become a valuable molecular technique in basic and translational biomedical research, and is emerging as an equally valuable clinical tool. Correlation of inter-samp...

    Authors: Maria B Lyng, Anne-Vibeke Lænkholm, Niels Pallisgaard and Henrik J Ditzel
    Citation: BMC Cancer 2008 8:20
    Content type: Research article Published on:

  8. Melanoma progression occurs through three major stages: radial growth phase (RGP), confined to the epidermis; vertical growth phase (VGP), when the tumor has invaded into the dermis; and metastasis. In this wo...

    Authors: Josane F Sousa and Enilza M Espreafico
    Citation: BMC Cancer 2008 8:19
    Content type: Research article Published on:

  9. In a previously published pilot study we explored the performance of microarrays in predicting clinical behaviour of ovarian tumours. For this purpose we performed microarray analysis on 20 patients and estima...

    Authors: Olivier Gevaert, Frank De Smet, Toon Van Gorp, Nathalie Pochet, Kristof Engelen, Frederic Amant, Bart De Moor, Dirk Timmerman and Ignace Vergote
    Citation: BMC Cancer 2008 8:18
    Content type: Research article Published on:

  10. Subclassification of ovarian carcinomas can be used to guide treatment and determine prognosis. Germline and somatic mutations, loss of heterozygosity (LOH), and epigenetic events such as promoter hypermethyla...

    Authors: Joshua Z Press, Alessandro De Luca, Niki Boyd, Sean Young, Armelle Troussard, Yolanda Ridge, Pardeep Kaurah, Steve E Kalloger, Katherine A Blood, Margaret Smith, Paul T Spellman, Yuker Wang, Dianne M Miller, Doug Horsman, Malek Faham, C Blake Gilks…
    Citation: BMC Cancer 2008 8:17
    Content type: Research article Published on:

  11. Cervical cancer is the second most common cancer in women worldwide. NK and cytotoxic T cells play an important role in the elimination of virus-infected and tumor cells through NKG2D activating receptors, whi...

    Authors: Naela A Arreygue-Garcia, Adrian Daneri-Navarro, Alicia del Toro-Arreola, Angel Cid-Arregui, Oscar Gonzalez-Ramella, Luis F Jave-Suarez, Adriana Aguilar-Lemarroy, Rogelio Troyo-Sanroman, Alejandro Bravo-Cuellar, Vidal Delgado-Rizo, Trinidad Garcia-Iglesias, Georgina Hernandez-Flores and Susana del Toro-Arreola
    Citation: BMC Cancer 2008 8:16
    Content type: Research article Published on:

  12. To investigate the neuropsychological outcome of children treated with surgery and posterior fossa irradiation for localized infratentorial ependymoma.

    Authors: Katja von Hoff, Virginie Kieffer, Jean-Louis Habrand, Chantal Kalifa, Georges Dellatolas and Jacques Grill
    Citation: BMC Cancer 2008 8:15
    Content type: Research article Published on:

  13. Endocan was originally described as a dermatan sulfate proteoglycan found freely circulating in the blood. Endocan expression confers tumorigenic properties to epithelial cell lines or accelerate the growth of...

    Authors: Florence Depontieu, Bogdan-Dragos Grigoriu, Arnaud Scherpereel, Estelle Adam, Maryse Delehedde, Philippe Gosset and Philippe Lassalle
    Citation: BMC Cancer 2008 8:14
    Content type: Research article Published on:

  14. Many cancer cells produce interleukin-6 (IL-6), a cytokine that plays a role in growth stimulation, metastasis, and angiogenesis of secondary tumours in a variety of malignancies, including colorectal cancer. ...

    Authors: Wolfgang Brozek, Giovanna Bises, Gerhild Fabjani, Heide S Cross and Meinrad Peterlik
    Citation: BMC Cancer 2008 8:13
    Content type: Research article Published on:

  16. Despite intensive multimodal treatment, outcome of patients with malignant glioma remains poor, and a standard dose of radiotherapy for anaplastic astrocytoma has not been defined. In the past RTOG study (83-0...

    Authors: Takuma Nomiya, Kenji Nemoto, Toshihiro Kumabe, Yoshihiro Takai and Shogo Yamada
    Citation: BMC Cancer 2008 8:11
    Content type: Research article Published on:

  17. EGFR overexpression has been described in many human tumours including gastric cancer. In NSCLC patients somatic EGFR mutations, within the kinase domain of the protein, as well as gene amplification were asso...

    Authors: Cátia Moutinho, Ana R Mateus, Fernanda Milanezi, Fátima Carneiro, Raquel Seruca and Gianpaolo Suriano
    Citation: BMC Cancer 2008 8:10
    Content type: Research article Published on:

  18. A number of recent studies have suggested that cancer incidence rates may be lower in patients receiving statin treatment for hypercholesterolemia. We examined the effects of statin drugs on in vitro proliferatio...

    Authors: Sharon A Glynn, Dermot O'Sullivan, Alex J Eustace, Martin Clynes and Norma O'Donovan
    Citation: BMC Cancer 2008 8:9
    Content type: Research article Published on:

  19. The objectives of this study were to evaluate long-term results of concurrent chemoradiotherapy (CRT) with 5-fluorouracil and cisplatin and the potential benefit of consolidation chemotherapy in patients with ...

    Authors: Byoung Chul Cho, Joong Bae Ahn, Jinsil Seong, Jae Kyung Roh, Joo Hang Kim, Hyun Cheol Chung, Joo Hyuk Sohn and Nam Kyu Kim
    Citation: BMC Cancer 2008 8:8
    Content type: Research article Published on:

  20. Medical research has not been able to establish whether a father's occupational exposures are associated with the development of acute leukemia (AL) in their offspring. The studies conducted have weaknesses th...

    Authors: Maria Luisa Perez-Saldivar, Manuel Carlos Ortega-Alvarez, Arturo Fajardo-Gutierrez, Roberto Bernaldez-Rios, Maria de los Angeles del Campo-Martinez, Aurora Medina-Sanson, Miguel Angel Palomo-Colli, Rogelio Paredes-Aguilera, Armando Martínez-Avalos, Victor Hugo Borja-Aburto, Maria de Jesus Rodriguez-Rivera, Victor Manuel Vargas-Garcia, Jesus Zarco-Contreras, Janet Flores-Lujano and Juan Manuel Mejia-Arangure
    Citation: BMC Cancer 2008 8:7
    Content type: Research article Published on:

  21. Estrogens are crucial tumorigenic hormones, which impact the cell growth and proliferation during breast cancer development. Estrogens are metabolized by a series of enzymes including COMT, which converts cate...

    Authors: Ummiye V Onay, Kirsimari Aaltonen, Laurent Briollais, Julia A Knight, Noel Pabalan, Outi Kilpivaara, Irene L Andrulis, Carl Blomqvist, Heli Nevanlinna and Hilmi Ozcelik
    Citation: BMC Cancer 2008 8:6
    Content type: Research article Published on:

  22. The retroperitoneal margin is frequently microscopically tumour positive in non-curative periampullary adenocarcinoma resections. This margin should be evaluated by serial perpendicular sectioning. The aim of ...

    Authors: Arne Westgaard, Svetlana Tafjord, Inger N Farstad, Milada Cvancarova, Tor J Eide, Oystein Mathisen, Ole Petter F Clausen and Ivar P Gladhaug
    Citation: BMC Cancer 2008 8:5
    Content type: Research article Published on:

  23. Lymphangiogenesis has become a new research frontier in tumor metastasis since the discovery of reliable lymphatic markers that have allowed observation and isolation of lymphatic endothelium. Cyclooxygenase-2...

    Authors: Xiao-Hua Zhang, Du-Ping Huang, Gui-Long Guo, Guo-Rong Chen, Hu-Xiang Zhang, Li Wan and Sheng-Ying Chen
    Citation: BMC Cancer 2008 8:4
    Content type: Research article Published on:

  24. The status of the EGFR and HER2-neu genes has not been fully defined in ovarian cancer. An integrated analysis of both genes could help define the proportion of patients that would potentially benefit from tar...

    Authors: Joanna Vermeij, Erik Teugels, Claire Bourgain, Ji Xiangming, Peter in 't Veld, Vanessa Ghislain, Bart Neyns and Jacques De Grève
    Citation: BMC Cancer 2008 8:3
    Content type: Research article Published on:

  25. High tumour interstitial fluid pressure (IFP) has been adversely linked to poor drug uptake in patients, and to treatment response following radiotherapy in cervix cancer patients. In this study we measured IF...

    Authors: Sarah Jane Lunt, Tuula MK Kalliomaki, Allison Brown, Victor X Yang, Michael Milosevic and Richard P Hill
    Citation: BMC Cancer 2008 8:2
    Content type: Research article Published on:

  26. Carbonic anhydrase IX is a hypoxia-induced enzyme that has many biologically important functions, including its role in cell adhesion and invasion.

    Authors: Sally Järvelä, Seppo Parkkila, Helena Bragge, Marketta Kähkönen, Anna-Kaisa Parkkila, Ylermi Soini, Silvia Pastorekova, Jaromir Pastorek and Hannu Haapasalo
    Citation: BMC Cancer 2008 8:1
    Content type: Research article Published on:

  27. Medicinal plant is a main source of cancer drug development. Some of the cycloartane triterpenoids isolated from the aerial part of Cimicifuga dahurica showed cytotoxicity in several cancer cell lines. It is of g...

    Authors: Ze Tian, Jianyong Si, Qi Chang, Liang Zhou, Shilin Chen, Peigen Xiao and Erxi Wu
    Citation: BMC Cancer 2007 7:237
    Content type: Research article Published on:

  29. Currently, there are no satisfactory biomarkers available to screen for diffuse large B cell lymphoma (DLBCL) or to identify patients who do not benefit from standard anti-cancer therapies. In this study, we u...

    Authors: Xing Zhang, Bo Wang, Xiao-shi Zhang, Zhi-ming Li, Zhong-zhen Guan and Wen-qi Jiang
    Citation: BMC Cancer 2007 7:235
    Content type: Research article Published on:

  30. The aim of our study was to investigate and evaluate the prognostic value of and correlations between preclinical and clinical factors such as the stage of the disease, blood Hb level before treatment, size of...

    Authors: Rūta Grigienė, Konstantinas P Valuckas, Eduardas Aleknavičius, Juozas Kurtinaitis and Simona R Letautienė
    Citation: BMC Cancer 2007 7:234
    Content type: Research article Published on:

  31. Small heat shock proteins are molecular chaperones that protect proteins against stress-induced aggregation. They have also been found to have anti-apoptotic activity and to play a part in the development of t...

    Authors: Eva Pozsgai, Eva Gomori, Andras Szigeti, Arpad Boronkai, Ferenc Gallyas Jr, Balazs Sumegi and Szabolcs Bellyei
    Citation: BMC Cancer 2007 7:233
    Content type: Research article Published on:

  32. The heat shock proteins (HSPs) 27-kDa (HSP27) and 72-kDa (HSP72), are ubiquitous chaperone molecules inducible in cells exposed to different stress conditions. Increased level of HSPs are reported in several h...

    Authors: Antonello A Romani, Pellegrino Crafa, Silvia Desenzani, Gallia Graiani, Costanza Lagrasta, Mario Sianesi, Paolo Soliani and Angelo F Borghetti
    Citation: BMC Cancer 2007 7:232
    Content type: Research article Published on:

  33. A platinum doublet is the current standard treatment for good performance status patients with advanced non-small cell lung cancer (NSCLC) and extensive stage small cell lung cancer (SCLC) with good performanc...

    Authors: Matthew A Beldner, Carol A Sherman, Mark R Green, Elizabeth Garrett-Mayer, Uzair Chaudhary, Mario L Meyer, Andrew S Kraft and Alberto J Montero
    Citation: BMC Cancer 2007 7:231
    Content type: Research article Published on:

  34. Although the diagnostic criteria and pathogenesis of gastrointestinal stromal tumors (GIST) have recently been elucidated, knowledge of the epidemiology of this malignancy is still limited. This study examined...

    Authors: Claudia Mucciarini, Giulio Rossi, Federica Bertolini, Riccardo Valli, Claudia Cirilli, Ivan Rashid, Luigi Marcheselli, Gabriele Luppi and Massimo Federico
    Citation: BMC Cancer 2007 7:230
    Content type: Research article Published on:

  35. Nasal NK/T cell lymphoma is an aggressive disease and has a poor prognosis. Nasal NK/T cell lymphoma is refractory to conventional chemotherapy and has strong tendency of widespread relapse or dissemination in...

    Authors: Koh-ichi Sakata, Masanori Someya, Mutsuko Omatsu, Hiroko Asanuma, Tadashi Hasegawa, Masato Hareyama and Tetsuo Himi
    Citation: BMC Cancer 2007 7:229
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2008 8:45

  36. The risk of sporadic colorectal cancer (CRC) is mainly associated with lifestyle factors, particularly dietary factors. Diets high in red meat and fat and low in fruit and vegetables are associated with an inc...

    Authors: Camilla F Skjelbred, Mona Sæbø, Anette Hjartåker, Tom Grotmol, Inger-Lise Hansteen, Kjell M Tveit, Geir Hoff and Elin H Kure
    Citation: BMC Cancer 2007 7:228
    Content type: Research article Published on:

  37. The prognosis for patients with advanced epithelial ovarian cancer remains poor despite aggressive surgical resection and platinum-based chemotherapy. More than 60% of patients will develop recurrent disease, ...

    Authors: Nathalie Rochet, Alexandra D Jensen, Florian Sterzing, Marc W Munter, Michael H Eichbaum, Andreas Schneeweiss, Christof Sohn, Juergen Debus and Wolfgang Harms
    Citation: BMC Cancer 2007 7:227
    Content type: Study protocol Published on:

  39. Carcinomas of unknown primary site (CUP) are epithelial malignancies revealed by metastatic lesions in the absence of any detectable primary tumor. Although they often adopt an aggressive clinical pattern, the...

    Authors: Delphine Lequin, Karim Fizazi, Saloua Toujani, Sylvie Souquère, Marie-Christine Mathieu, Pierre Hainaut, Alain Bernheim, Françoise Praz and Pierre Busson
    Citation: BMC Cancer 2007 7:225
    Content type: Research article Published on:

  40. Platelet-derived growth factor (PDGF)-BB and PDGF receptor (PDGFR)-β are mainly expressed in the developing vasculature, where PDGF-BB is produced by endothelial cells and PDGFR-β is expressed by mural cells, ...

    Authors: Shioto Suzuki, Carl-Henrik Heldin and Rainer Lothar Heuchel
    Citation: BMC Cancer 2007 7:224
    Content type: Research article Published on:

  41. Ovarian cancer (OvCa) most often derives from ovarian surface epithelial (OSE) cells. Several lines of evidence strongly suggest that increased exposure to progesterone (P4) protects women against developing O...

    Authors: Cathy B Wilcox, Grace O Feddes, Joan E Willett-Brozick, Lih-Ching Hsu, Julie A DeLoia and Bora E Baysal
    Citation: BMC Cancer 2007 7:223
    Content type: Research article Published on:

  42. Breast cancer in young Saudi women is a crucial problem. According to the 2002 annual report of Saudi National Cancer Registry, breast cancers that developed before the age of 40 comprise 26.4% of all female b...

    Authors: Naser Elkum, Said Dermime, Dahish Ajarim, Ali Al-Zahrani, Adher Alsayed, Asma Tulbah, Osama Al Malik, Mohamed Alshabanah, Adnan Ezzat and Taher Al-Tweigeri
    Citation: BMC Cancer 2007 7:222
    Content type: Research article Published on:

  43. COX-2 inhibitors, such as celecoxib, and ubiquitin-proteasome pathway inhibitors, such as bortezomib, can down-regulate NF-κB, a transcription factor implicated in tumor growth. The objective of this study was...

    Authors: John Hayslip, Uzair Chaudhary, Mark Green, Mario Meyer, Steven Dunder, Carol Sherman, Shanta Salzer, Andrew Kraft and Alberto J Montero
    Citation: BMC Cancer 2007 7:221
    Content type: Research article Published on:

  44. RhoB is down-regulated in most lung cancer cell lines and tumor tissues when compared with their normal counterparts. The mechanism of this loss of expression is not yet deciphered.

    Authors: Julien Mazières, Daniel Tovar, Biao He, Jacobo Nieto-Acosta, Claire Marty-Detraves, Carine Clanet, Anne Pradines, David Jablons and Gilles Favre
    Citation: BMC Cancer 2007 7:220
    Content type: Research article Published on:

  45. The lymphatics form a second circulatory system that drains the extracellular fluid and proteins from the tumor microenvironment, and provides an exclusive environment in which immune cells interact and respon...

    Authors: Marcia R Saban, Rheal Towner, Nataliya Smith, Andrew Abbott, Michal Neeman, Carole A Davis, Cindy Simpson, Julie Maier, Sylvie Mémet, Xue-Ru Wu and Ricardo Saban
    Citation: BMC Cancer 2007 7:219
    Content type: Research article Published on:

  46. In comparative pathology, canine mammary tumours have special interest because of their similarities with human breast cancer. Mixed tumours are uncommon lesions in the human breast, but they are found most fr...

    Authors: Marisa CLS Genelhu, Sérgio V Cardoso, Helenice Gobbi and Geovanni D Cassali
    Citation: BMC Cancer 2007 7:218
    Content type: Research article Published on:

  49. TGFβ is critical to control hepatocyte proliferation by inducing G1-growth arrest through multiple pathways leading to inhibition of E2F transcription activity. The retinoblastoma protein pRb is a key controll...

    Authors: Sharon Sheahan, Christopher O Bellamy, Donald R Dunbar, David J Harrison and Sandrine Prost
    Citation: BMC Cancer 2007 7:215
    Content type: Research article Published on:

  50. We conducted a case-control study to evaluate the role of UDP-glucuronosyltransferase 1A7 (UGT1A7) polymorphisms in the onset of hepatocellular carcinoma (HCC).

    Authors: I Stücker, MA Loriot, G N'Koutchou, S Cénée, L Bodin, C Mulot, M Gelu-Simeon, L Pelletier, JP Bronowicki, F Degos, P Beaune, P Laurent-Puig, D Hémon, JC Trinchet and G Pelletier
    Citation: BMC Cancer 2007 7:214
    Content type: Research article Published on:

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