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  1. Pancreatic cancer is one of the most aggressive human malignancies, with a very poor prognosis. To evaluate the effect of angiotensin II (Ang II) type 2 receptor (AT2) expression in the host's body on the growth ...

    Authors: Chiyo Doi, Noboru Egashira, Atsushi Kawabata, Dharmendra Kumar Maurya, Naomi Ohta, Deepthi Uppalapati, Rie Ayuzawa, Lara Pickel, Yuka Isayama, Deryl Troyer, Susumu Takekoshi and Masaaki Tamura
    Citation: BMC Cancer 2010 10:67
    Content type: Research article Published on:

  2. Tumor initiating cells (TICs) provide a new paradigm for developing original therapeutic strategies.

    Authors: Cristina Patru, Luciana Romao, Pascale Varlet, Laure Coulombel, Eric Raponi, Josette Cadusseau, François Renault-Mihara, Cécile Thirant, Nadine Leonard, Alain Berhneim, Maria Mihalescu-Maingot, Jacques Haiech, Ivan Bièche, Vivaldo Moura-Neto, Catherine Daumas-Duport, Marie-Pierre Junier…
    Citation: BMC Cancer 2010 10:66
    Content type: Research article Published on:

  3. Cutaneous melanoma (CM) is the most lethal form of skin malignancy, which registers a constant increase in incidence worldwide. The identification of molecular alteration(s) involved in its biological aggressi...

    Authors: Massimo Mascolo, Maria Luisa Vecchione, Gennaro Ilardi, Massimiliano Scalvenzi, Guido Molea, Maria Di Benedetto, Loredana Nugnes, Maria Siano, Gaetano De Rosa and Stefania Staibano
    Citation: BMC Cancer 2010 10:63
    Content type: Research article Published on:

  4. Appendiceal adenocarcinoma is rare with a frequency of 0.08% of all surgically removed appendices. Few cases of appendiceal carcinoma infiltrating the bladder wall for spatial contiguity have been documented.

    Authors: Gianluigi Taverna, Matteo Corinti, Piergiuseppe Colombo, Fabio Grizzi, Mauro Severo, Alessando Piccinelli, Guido Giusti, Alessio Benetti, Paolo A Zucali and Pierpaolo Graziotti
    Citation: BMC Cancer 2010 10:62
    Content type: Case report Published on:

  5. It has been suggested that columnar cell lesions indicate an alteration of the human mammary gland involved in the development of breast cancer. They have not previously been described in canine mammary gland....

    Authors: Enio Ferreira, Helenice Gobbi, Bruna S Saraiva and Geovanni D Cassali
    Citation: BMC Cancer 2010 10:61
    Content type: Research article Published on:

  7. Pancreatic ductal adenocarcinoma is a lethal disease with a 5-year survival rate of 4% and typically presents in an advanced stage. In this setting, prognostic markers identifying the more agrressive tumors co...

    Authors: David F Schaeffer, Daniel R Owen, Howard J Lim, Andrew K Buczkowski, Stephen W Chung, Charles H Scudamore, David G Huntsman, Sylvia SW Ng and David A Owen
    Citation: BMC Cancer 2010 10:59
    Content type: Research article Published on:

  8. PMS2 expression loss was reported in a variety of human. However, its importance has not been fully understood in cervical carcinoma. The aim of this study was to determine the expression of PMS2 in cervical c...

    Authors: Yuan Zhang, Yi Min Shu, Shu Fang Wang, Bang Hong Da, Ze Hua Wang and Hua Bin Li
    Citation: BMC Cancer 2010 10:58
    Content type: Research article Published on:

  10. We have recently described the correlation between quantitative measures of HER2 expression or HER2 homodimers by the HERmark assay and objective response (RR), time-to progression (TTP), and overall survival ...

    Authors: Masakazu Toi, Jeff Sperinde, Weidong Huang, Shigehira Saji, John Winslow, Xueguang Jin, Yuping Tan, Shinji Ohno, Seigo Nakamura, Hiroji Iwata, Norikazu Masuda, Kenjiro Aogi, Satoshi Morita, Christos Petropoulos and Michael Bates
    Citation: BMC Cancer 2010 10:56
    Content type: Research article Published on:

  11. Non-Hodgkin lymphoma (NHL) is a hematologic malignancy for which good diagnostic markers are lacking. Despite continued improvement in our understanding of NHL, efforts to identify diagnostic markers have yiel...

    Authors: Byong Chul Yoo, Sun-Young Kong, Sang-Geun Jang, Kyung-Hee Kim, Sun-A Ahn, Weon-Seo Park, Sohee Park, Tak Yun and Hyeon-Seok Eom
    Citation: BMC Cancer 2010 10:55
    Content type: Research article Published on:

  12. Malignant pleural mesothelioma is a rare disease known to be resistant to conventional therapies. A better understanding of mesothelioma biology may provide the rationale for new therapeutic strategies. In thi...

    Authors: Alice Melotti, Antonio Daga, Daniela Marubbi, Annalisa Zunino, Luciano Mutti and Giorgio Corte
    Citation: BMC Cancer 2010 10:54
    Content type: Research article Published on:

  13. We evaluated two molecular methods of HPV detection and their correlation with cytological and histological diagnosis in a large sample of Greek women.

    Authors: Sotirios Tsiodras, John Georgoulakis, Aikaterini Chranioti, Zanis Voulgaris, Amanda Psyrri, Angeliki Tsivilika, John Panayiotides and Petros Karakitsos
    Citation: BMC Cancer 2010 10:53
    Content type: Research article Published on:

  14. For years the Robert Koch Institute (RKI) has been annually pooling and reviewing the data from the German population-based cancer registries and evaluating them together with the cause-of-death statistics pro...

    Authors: Jörg Haberland, Joachim Bertz, Ute Wolf, Thomas Ziese and Bärbel-Maria Kurth
    Citation: BMC Cancer 2010 10:52
    Content type: Research article Published on:

  15. Osteosarcoma often develops micrometastases in the lung prior to diagnosis, causing a fatal outcome. Therefore, the prevention of pulmonary metastases is critical for the improvement of the prognosis of patien...

    Authors: Junichi Aizawa, Kenshi Sakayama, Setsuya Kamei, Teruki Kidani, Haruyasu Yamamoto, Yoshiaki Norimatsu and Hiroshi Masuno
    Citation: BMC Cancer 2010 10:51
    Content type: Research article Published on:

  16. A frequent manifestation of advanced NSCLC is malnutrition, even though there are many studies which relate it with a poor survival, its relation with toxicity has not yet been consistently reported. The aim o...

    Authors: Oscar Arrieta, Rosa M Michel Ortega, Geraldine Villanueva-Rodríguez, Maria G Serna-Thomé, Diana Flores-Estrada, Consuelo Diaz-Romero, Cindy M Rodríguez, Luis Martínez and Karla Sánchez-Lara
    Citation: BMC Cancer 2010 10:50
    Content type: Research article Published on:

  17. Gefitinib is one of the small molecule inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR TKIs). Clinical trials have demonstrated it is effective for treatment of a subset of patients with a...

    Authors: Dan-Fang Yan, Sen-Xiang Yan, Jing-Song Yang, Yi-Xiang J Wang, Xiao-Li Sun, Xin-Biao Liao and Jun-Qing Liu
    Citation: BMC Cancer 2010 10:49
    Content type: Case report Published on:

  18. Epigenetic silencing of the MGMT gene by promoter methylation is associated with loss of MGMT expression, diminished DNA-repair activity and longer overall survival in patients with glioblastoma who, in addition ...

    Authors: Luca Morandi, Enrico Franceschi, Dario de Biase, Gianluca Marucci, Alicia Tosoni, Mario Ermani, Annalisa Pession, Giovanni Tallini and Alba Brandes
    Citation: BMC Cancer 2010 10:48
    Content type: Technical advance Published on:

  19. Half of the familial aggregation of ovarian cancer can't be explained by any known risk genes, suggesting the existence of other genetic risk factors. Some of these unknown factors may not be traditional prote...

    Authors: Jie Shen, Richard DiCioccio, Kunle Odunsi, Shashikant B Lele and Hua Zhao
    Citation: BMC Cancer 2010 10:47
    Content type: Research article Published on:

  20. The crude extract of the fruit bearing plant, Physalis peruviana (golden berry), demonstrated anti-hepatoma and anti-inflammatory activities. However, the cellular mechanism involved in this process is still unkn...

    Authors: Ching-Yu Yen, Chien-Chih Chiu, Fang-Rong Chang, Jeff Yi-Fu Chen, Chi-Ching Hwang, You-Cheng Hseu, Hsin-Ling Yang, Alan Yueh-Luen Lee, Ming-Tz Tsai, Zong-Lun Guo, Yu-Shan Cheng, Yin-Chang Liu, Yu-Hsuan Lan, Yu-Ching Chang, Ying-Chin Ko, Hsueh-Wei Chang…
    Citation: BMC Cancer 2010 10:46
    Content type: Research article Published on:

  21. The treatment paradigm in advanced renal cell carcinoma (RCC) has changed in the recent years. Sunitinib has been established as a new standard for first-line therapy. We studied the prognostic significance of...

    Authors: Aristotelis Bamias, Alexandra Karadimou, Sofia Lampaki, George Lainakis, Lia Malettou, Eleni Timotheadou, Kostas Papazisis, Charalambos Andreadis, Loukas Kontovinis, Ioannis Anastasiou, Kostas Stravodimos, Ioannis Xanthakis, Andreas Skolarikos, Christos Christodoulou, Kostas Syrigos, Christos Papandreou…
    Citation: BMC Cancer 2010 10:45
    Content type: Research article Published on:

  22. Alu methylation is correlated with the overall level of DNA methylation and recombination activity of the genome. However, the maintenance and methylation status of each CpG site within Alu elements (Alu) and it...

    Authors: Shengyan Xiang, Zhaojun Liu, Baozhen Zhang, Jing Zhou, Bu-Dong Zhu, Jiafu Ji and Dajun Deng
    Citation: BMC Cancer 2010 10:44
    Content type: Research article Published on:

  23. Aberrant regulation in the invasion of cancer cells is closely associated with their metastatic potentials. TrkB functions as a receptor tyrosine kinase and is considered to facilitate tumor metastasis. Pyk2 i...

    Authors: Siyang Zhang, Dawei Guo, Wenting Luo, Qingfu Zhang, Ying Zhang, Chunyan Li, Yao Lu, Zeshi Cui and Xueshan Qiu
    Citation: BMC Cancer 2010 10:43
    Content type: Research article Published on:

  24. Many cancer survivors suffer a range of physical and psychological symptoms which may persist for months or years after cessation of treatment. Despite the known benefits of exercise and its potential to addre...

    Authors: Julie M Walsh, Juliette Hussey, Emer Guinan and Dearbhaile O' Donnell
    Citation: BMC Cancer 2010 10:42
    Content type: Study protocol Published on:

  25. Cell transformation by the Src tyrosine kinase is characterized by extensive changes in gene expression. In this study, we took advantage of several strains of the Rous sarcoma virus (RSV) to characterize the ...

    Authors: Bart M Maślikowski, Benjamin D Néel, Ying Wu, Lizhen Wang, Natalie A Rodrigues, Germain Gillet and Pierre-André Bédard
    Citation: BMC Cancer 2010 10:41
    Content type: Research article Published on:

  26. GPR110 is an orphan G protein-coupled receptor--a receptor without a known ligand, a known signaling pathway, or a known function. Despite the lack of information, one can assume that orphan receptors have imp...

    Authors: Amy M Lum, Bruce B Wang, Gabriele B Beck-Engeser, Lauri Li, Namitha Channa and Matthias Wabl
    Citation: BMC Cancer 2010 10:40
    Content type: Research article Published on:

  27. To investigate the outcome of locoregionally advanced nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiation therapy (IMRT) after induction chemotherapy, with or without concomitant chemothe...

    Authors: Shaojun Lin, Jiade Jay Lu, Lu Han, Qisong Chen and Jianji Pan
    Citation: BMC Cancer 2010 10:39
    Content type: Research article Published on:

  28. Although Argonaute proteins are considered to play important roles in stem cell self-renewal, RNA interference (RNAi) and translational regulation, relatively little is known about their functions in human dis...

    Authors: Lan Li, Chaohui Yu, Hengjun Gao and Youming Li
    Citation: BMC Cancer 2010 10:38
    Content type: Research article Published on:

  29. The purpose of the work reported here is to test reliable molecular profiles using routinely processed formalin-fixed paraffin-embedded (FFPE) tissues from participants of the clinical trial BIG 1-98 with a me...

    Authors: Janine Antonov, Vlad Popovici, Mauro Delorenzi, Pratyaksha Wirapati, Anna Baltzer, Andrea Oberli, Beat Thürlimann, Anita Giobbie-Hurder, Giuseppe Viale, Hans Jörg Altermatt, Stefan Aebi and Rolf Jaggi
    Citation: BMC Cancer 2010 10:37
    Content type: Research article Published on:

  30. Aromatase (CYP19A1) regulates estrogen biosynthesis. Polymorphisms in CYP19A1 have been related to the pathogenesis of breast cancer (BC). Inhibition of aromatase with letrozole constitutes the best option for tr...

    Authors: Zaida Garcia-Casado, Angel Guerrero-Zotano, Antonio Llombart-Cussac, Ana Calatrava, Antonio Fernandez-Serra, Amparo Ruiz-Simon, Joaquin Gavila, Miguel A Climent, Sergio Almenar, Jose Cervera-Deval, Josefina Campos, Carlos Vazquez Albaladejo, Antonio Llombart-Bosch, Vicente Guillem and Jose A Lopez-Guerrero
    Citation: BMC Cancer 2010 10:36
    Content type: Research article Published on:

  31. Socioeconomic status (SES) is known to be positively associated with breast cancer risk but its relationship with mammographic density, a marker of susceptibility to breast cancer, is unclear. This study aims ...

    Authors: Zoe Aitken, Kate Walker, Bernardine H Stegeman, Petra A Wark, Sue M Moss, Valerie A McCormack and Isabel dos Santos Silva
    Citation: BMC Cancer 2010 10:35
    Content type: Research article Published on:

  32. Onconase represents a new class of RNA-damaging drugs. Mechanistically, Onconase is thought to internalize, where it degrades intracellular RNAs such as tRNA and double-stranded RNA, and thereby suppresses pro...

    Authors: Deborah A Altomare, Susanna M Rybak, Jianming Pei, Jacob V Maizel, Mitchell Cheung, Joseph R Testa and Kuslima Shogen
    Citation: BMC Cancer 2010 10:34
    Content type: Research article Published on:

  33. Heparanase facilitates the invasion and metastasis of cancer cells, and is over-expressed in many kinds of malignancies. Our studies indicated that heparanase was frequently expressed in advanced gastric cance...

    Authors: Liduan Zheng, Guosong Jiang, Hong Mei, Jiarui Pu, Jihua Dong, Xiaohua Hou and Qiangsong Tong
    Citation: BMC Cancer 2010 10:33
    Content type: Research article Published on:

  34. Epigenetic changes associated with promoter DNA methylation results in silencing of several tumor suppressor genes that lead to increased risk for tumor formation and for progression of the cancer.

    Authors: Yanyuan Wu, Monica Alvarez, Dennis J Slamon, Phillip Koeffler and Jaydutt V Vadgama
    Citation: BMC Cancer 2010 10:32
    Content type: Research article Published on:

  35. Endometrial cancer is the most common gynecologic malignancy in Puerto Rico and the United States (US).

    Authors: Ana Patricia Ortiz, Javier Pérez, Yomayra Otero-Domínguez, Omar García-Rodríguez, Sheyla Garced-Tirado, Frances Escalera-Maldonado, Sadja Gaud-Quintana, Elvis Santiago-Rodríguez, Katherine Svensson, José L Vergara-Arroyo, Karen Ortiz, Mariela Torres, Guillermo Tortolero-Luna and Nayda Figueroa-Vallés
    Citation: BMC Cancer 2010 10:31
    Content type: Research article Published on:

  36. The prognosis for patients with recurrent glioblastoma is still poor with a median survival between 3 and 6 months. Reports about the application of carmustine (BCNU), one of the standard chemotherapeutic drug...

    Authors: Thomas Reithmeier, Erika Graf, Tobias Piroth, Michael Trippel, Marcus O Pinsker and Guido Nikkhah
    Citation: BMC Cancer 2010 10:30
    Content type: Research article Published on:

  37. Angiogenesis is the formation of neovasculature from a pre-existing vascular network. Progression of solid tumors including lung cancer is angiogenesis-dependent. We previously introduced a bioinformatics-base...

    Authors: Jacob E Koskimaki, Emmanouil D Karagiannis, Benjamin C Tang, Hans Hammers, D Neil Watkins, Roberto Pili and Aleksander S Popel
    Citation: BMC Cancer 2010 10:29
    Content type: Research article Published on:

  38. Combinations of trastuzumab with either docetaxel or vinorelbine are considered valuable treatment options for HER2-positive metastatic breast cancer patients. We performed a retrospective comparison of the cl...

    Authors: Stefania Redana, Michela Donadio, Franco Nolè, Maria Elena Jacomuzzi, Alessandra Beano, Rossella Martinello, Anna Sapino, Giuseppe Viale, Massimo Aglietta and Filippo Montemurro
    Citation: BMC Cancer 2010 10:28
    Content type: Research article Published on:

  39. Substantial data indicate that the oncogene microRNA 21 (miR-21) is significantly elevated in glioblastoma multiforme (GBM) and regulates multiple genes associated with cancer cell proliferation, apoptosis, an...

    Authors: Yu Ren, Xuan Zhou, Mei Mei, Xu-Bo Yuan, Lei Han, Guang-Xiu Wang, Zhi-Fan Jia, Peng Xu, Pei-Yu Pu and Chun-Sheng Kang
    Citation: BMC Cancer 2010 10:27
    Content type: Research article Published on:

  40. The objective of this study was to conduct a cost-effectiveness evaluation of pemetrexed compared to docetaxel in the treatment of advanced or metastatic non-small cell lung cancer (NSCLC) for patients with pr...

    Authors: Yumi Asukai, Amparo Valladares, Carlos Camps, Eifiona Wood, Kaisa Taipale, Jorge Arellano, Alejo Cassinello, José Antonio Sacristán and Tatiana Dilla
    Citation: BMC Cancer 2010 10:26
    Content type: Research article Published on:

  41. Currently, the TNM staging system is a widely accepted method for assessing the prognosis of the disease and planning therapeutic strategies for cancer. Of the TNM system, the extent of lymph node involvement ...

    Authors: Do Hyoung Lim, Hyeong Su Kim, Young Suk Park, Jeeyun Lee, Se Hoon Park, Ho Yeong Lim, Sang Hoon Ji, Min Jae Park, Seong Yoon Yi, Ji Yeong An, Tae Sung Sohn, Jae Hyoung Noh, Jae Moon Bae, Sung Kim, Cheol Keun Park and Won Ki Kang
    Citation: BMC Cancer 2010 10:25
    Content type: Research article Published on:

  43. CXCL12 is a chemokine that is constitutively expressed in many organs and tissues. CXCL12 promoter hypermethylation has been detected in primary breast tumours and contributes to their metastatic potential. It ha...

    Authors: Edneia AS Ramos, Anamaria A Camargo, Karin Braun, Renata Slowik, Iglenir J Cavalli, Enilze MSF Ribeiro, Fábio de O Pedrosa, Emanuel M de Souza, Fabrício F Costa and Giseli Klassen
    Citation: BMC Cancer 2010 10:23
    Content type: Research article Published on:

  44. Adequate surgery still remains the only curative treatment of chordoma. Interesting clinical data on advanced disease with molecularly targeted therapies were reported.

    Authors: Virginia Ferraresi, Carmen Nuzzo, Carmine Zoccali, Ferdinando Marandino, Antonello Vidiri, Nicola Salducca, Massimo Zeuli, Diana Giannarelli, Francesco Cognetti and Roberto Biagini
    Citation: BMC Cancer 2010 10:22
    Content type: Research article Published on:

  45. S100 calcium binding protein A8 (S100A8) has been implicated as a prognostic indicator in several types of cancer. However, previous studies are limited in their ability to predict the clinical behavior of the c...

    Authors: Seon-Kyu Kim, Eun-Jung Kim, Sun-Hee Leem, Yun-Sok Ha, Yong-June Kim and Wun-Jae Kim
    Citation: BMC Cancer 2010 10:21
    Content type: Research article Published on:

  46. Glucose regulated protein 78 (Grp78) is involved in the invasion and metastasis in many human cancers including gastric cancer, breast cancer, prostate cancer. But the role of Grp78 in the invasion of human he...

    Authors: Rongjian Su, Zhen Li, Hongdan Li, Huijuan Song, Cuifen Bao, Jia Wei and Liufang Cheng
    Citation: BMC Cancer 2010 10:20
    Content type: Research article Published on:

  47. HPV has been found repeatedly in esophageal carcinoma tissues. However, reported detection rates of HPV DNA in these tumors have varied markedly. Differences in detection methods, sample types, and geographic ...

    Authors: Xueqian Wang, Xiuyun Tian, Fangfang Liu, Yiqiang Zhao, Min Sun, Dafang Chen, Changdong Lu, Zhong Wang, Xiaotian Shi, Qingying Zhang, Donghong Zhang, Zhongying Shen, Feng Li, Curtis C Harris, Hong Cai and Yang Ke
    Citation: BMC Cancer 2010 10:19
    Content type: Research article Published on:

  48. In this study was investigate IAPs in normal human prostate (NP), benign prostatic hyperplasia (BPH), prostatic intraepithelial neoplasia (PIN) and prostatic carcinoma (PC), and their involvement in apoptosis/...

    Authors: Gonzalo Rodríguez-Berriguete, Benito Fraile, Fermín R de Bethencourt, Angela Prieto-Folgado, Nahikari Bartolome, Claudia Nuñez, Bruna Prati, Pilar Martínez-Onsurbe, Gabriel Olmedilla, Ricardo Paniagua and Mar Royuela
    Citation: BMC Cancer 2010 10:18
    Content type: Research article Published on:

  49. High activity of cysteine proteases such as legumain and the cathepsins have been shown to facilitate growth and invasion of a variety of tumor types. In breast cancer, several recent studies have indicated th...

    Authors: Jon J Briggs, Mads H Haugen, Harald T Johansen, Adam I Riker, Magnus Abrahamson, Øystein Fodstad, Gunhild M Mælandsmo and Rigmor Solberg
    Citation: BMC Cancer 2010 10:17
    Content type: Research article Published on:

  50. Dysregulated CD44 expression characterizes most human cancers, including prostate cancer (PCa). PCa loses expression of CD44 standard (CD44s) that is present in benign epithelium, and overexpresses the novel s...

    Authors: Kui Yang, Yaqiong Tang, Gabriel K Habermehl and Kenneth A Iczkowski
    Citation: BMC Cancer 2010 10:16
    Content type: Research article Published on:

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