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  1. Previous studies have shown that the ADIPOR1, ADORA1, BTG2 and CD46 genes differ significantly between long-term survivors of breast cancer and deceased patients, both in levels of gene expression and DNA copy nu...

    Authors: Elin Möllerström, Anikó Kovács, Kristina Lövgren, Szilard Nemes, Ulla Delle, Anna Danielsson, Toshima Parris, Donal J Brennan, Karin Jirström, Per Karlsson and Khalil Helou
    Citation: BMC Cancer 2010 10:296
    Content type: Research article Published on:

  2. Metastasis is a multi-step process that is responsible for the majority of deaths in cancer patients. Current treatments are not effective in targeting metastasis. The molecular chaperone hsp90α is secreted fr...

    Authors: Jessica McCready, Jessica D Sims, Doug Chan and Daniel G Jay
    Citation: BMC Cancer 2010 10:294
    Content type: Research article Published on:

  3. Molecularly targeted drugs inhibit aberrant signaling within oncogenic pathways. Identifying the predominant pathways at work within a tumor is a key step towards tailoring therapies to the patient. Clinical s...

    Authors: Yogesh M Kulkarni, Vivian Suarez and David J Klinke II
    Citation: BMC Cancer 2010 10:291
    Content type: Research article Published on:

  4. Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies. Early diagnosis is critical for guiding the therapeutic management of ESCC. It is imperative to find more effective biomarkers ...

    Authors: Xi Zhu, Ming Ding, Mei-Lan Yu, Ming-Xiang Feng, Li-Jie Tan and Fu-Kun Zhao
    Citation: BMC Cancer 2010 10:290
    Content type: Research article Published on:

  5. Diabetes is associated with an increased risk of several malignancies. Both diabetic patients and patients with cancer have an increase in platelet reactivity and platelet activation has recently emerged as a ...

    Authors: Chris E Holmes, Maria E Ramos-Nino and Benjamin Littenberg
    Citation: BMC Cancer 2010 10:289
    Content type: Research article Published on:

  6. Decreased expression of the angiogenesis inhibitor ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif, 1) has previously been reported during prostate cancer progression. The aim of this study was...

    Authors: Heléne Gustavsson, Tajana Tešan, Karin Jennbacken, Kouji Kuno, Jan-Erik Damber and Karin Welén
    Citation: BMC Cancer 2010 10:288
    Content type: Research article Published on:

  7. Signal transduction processes mediated by phosphatidyl inositol phosphates affect a broad range of cellular processes such as cell cycle progression, migration and cell survival. The protein kinase AKT is one ...

    Authors: Till Krech, Margarethe Thiede, Ellen Hilgenberg, Reinhold Schäfer and Karsten Jürchott
    Citation: BMC Cancer 2010 10:287
    Content type: Research article Published on:

  8. Epigenetic aberrations and a CpG island methylator phenotype have been shown to be associated with poor outcomes in children with neuroblastoma (NB). Seven cancer related genes (THBS-1, CASP8, HIN-1, TIG-1, BLU, ...

    Authors: Qiwei Yang, Yufeng Tian, Kelly R Ostler, Alexandre Chlenski, Lisa J Guerrero, Helen R Salwen, Lucy A Godley and Susan L Cohn
    Citation: BMC Cancer 2010 10:286
    Content type: Research article Published on:

  9. We conducted a case-control study in the greater Toronto area to evaluate potential lung cancer risk factors including environmental tobacco smoke (ETS) exposure, family history of cancer, indoor air pollution...

    Authors: Darren R Brenner, Rayjean J Hung, Ming-Sound Tsao, Frances A Shepherd, Michael R Johnston, Steven Narod, Warren Rubenstein and John R McLaughlin
    Citation: BMC Cancer 2010 10:285
    Content type: Research article Published on:

  11. Interleukin-8 (IL-8/CXCL-8) is a prototype of the ELR+CXC chemokines that play an important role in the promotion and progression of many human cancers including breast cancer. We have recently showed the implica...

    Authors: Kaouther Snoussi, Wijden Mahfoudh, Noureddine Bouaouina, Meriem Fekih, Hedi Khairi, Ahmed N Helal and Lotfi Chouchane
    Citation: BMC Cancer 2010 10:283
    Content type: Research article Published on:

  12. The alkylating agent Dacarbazine (DTIC) has been used in the treatment of melanoma for decades, but when used as a monotherapy for cancer only moderate response rates are achieved. Recently, the clinical use o...

    Authors: Thilakavathy Thangasamy, Sivanandane Sittadjody, Geoffrey C Mitchell, Erin E Mendoza, Vijayababu M Radhakrishnan, Kirsten H Limesand and Randy Burd
    Citation: BMC Cancer 2010 10:282
    Content type: Research article Published on:

  13. The rates of chemotherapy-induced amenorrhea (CIA) associated with docetaxel-based regimens reported by previous studies are discordant. For navelbine-based chemotherapies, rates of CIA have seldom been reported.

    Authors: Wen-Bin Zhou, Hong Yin, Xiao-An Liu, Xiao-Ming Zha, Lin Chen, Jun-Cheng Dai, Ai-di Tao, Ling Chen, Jing-Jing Ma, Li-Jun Ling and Shui Wang
    Citation: BMC Cancer 2010 10:281
    Content type: Research article Published on:

  14. Aneuploidy, centrosome abnormalities and gene amplification are hallmarks of chromosome instability (CIN) in cancer. Yet there are no studies of the in vivo behavior of these phenomena within the same bladder tum...

    Authors: Javier del Rey, Esther Prat, Immaculada Ponsa, Josep Lloreta, Antoni Gelabert, Ferran Algaba, Jordi Camps and Rosa Miró
    Citation: BMC Cancer 2010 10:280
    Content type: Research article Published on:

  15. Genetic testing for hereditary colorectal cancer (HCRC) had significant psychological consequences for test recipients. This prospective longitudinal study investigated the factors that predict psychological r...

    Authors: Samuel MY Ho, Judy WC Ho, George A Bonanno, Annie TW Chu and Emily MS Chan
    Citation: BMC Cancer 2010 10:279
    Content type: Research article Published on:

  16. Cervical cancer, caused by specific oncogenic types of human papillomavirus (HPV), is the second most common cancer in women worldwide. A large number of young sexually active women get infected by HPV but onl...

    Authors: Koushik Chatterjee, Collet Dandara, Margaret Hoffman and Anna-Lise Williamson
    Citation: BMC Cancer 2010 10:278
    Content type: Research article Published on:

  17. Overall survival (OS) is the gold standard for the demonstration of a clinical benefit in cancer trials. Replacement of OS by a surrogate endpoint allows to reduce trial duration. To date, few surrogate endpoi...

    Authors: Nicolas Methy, Laurent Bedenne and Franck Bonnetain
    Citation: BMC Cancer 2010 10:277
    Content type: Research article Published on:

  18. Epigallocatechin-3-gallate (EGCG), one of the major catechins in green tea, is a potential chemopreventive agent for various cancers. The aim of this study was to examine the effect of EGCG on the expression o...

    Authors: Phan LCHB Tran, Soo-A Kim, Hong Seok Choi, Jung-Hoon Yoon and Sang-Gun Ahn
    Citation: BMC Cancer 2010 10:276
    Content type: Research article Published on:

  19. Fas (Apo-1/CD95) and its specific ligand (FasL) are key elements in apoptosis. They have been studied in different malignancies but there are few published studies about the soluble forms of these markers (i.e...

    Authors: Samaneh Boroumand-Noughabi, Hamid Reza Sima, Kamran Ghaffarzadehgan, Mostafa Jafarzadeh, Hamid Reza Raziee, Hanieh Hosseinnezhad, Omeed Moaven, Mohammad Taghi Rajabi-Mashhadi, Amir Abbas Azarian, Mojtaba Mashhadinejad and Jalil Tavakkol-Afshari
    Citation: BMC Cancer 2010 10:275
    Content type: Technical advance Published on:

  20. It is uncertain whether smoking is related to colorectal cancer risk. Cytochrome P-450 CYP1A1, glutathione-S-transferase (GST) and NAD(P)H:quinone oxidoreductase 1 (NQO1) are important enzymes in the metabolis...

    Authors: Hoirun Nisa, Suminori Kono, Guang Yin, Kengo Toyomura, Jun Nagano, Ryuichi Mibu, Masao Tanaka, Yoshihiro Kakeji, Yoshihiko Maehara, Takeshi Okamura, Koji Ikejiri, Kitaroh Futami, Takafumi Maekawa, Yohichi Yasunami, Kenji Takenaka, Hitoshi Ichimiya…
    Citation: BMC Cancer 2010 10:274
    Content type: Research article Published on:

  21. Expression of periostin is an indicator of epithelial-mesenchymal transition in cancer but a detailed analysis of periostin expression in prostate cancer has not been conducted so far.

    Authors: Verena Tischler, Florian R Fritzsche, Peter J Wild, Carsten Stephan, Hans-Helge Seifert, Marc-Oliver Riener, Thomas Hermanns, Ashkan Mortezavi, Josefine Gerhardt, Peter Schraml, Klaus Jung, Holger Moch, Alex Soltermann and Glen Kristiansen
    Citation: BMC Cancer 2010 10:273
    Content type: Research article Published on:

  22. Fatigue is a major problem of cancer patients. Thirty percent of cancer survivors report serious fatigue three years after finishing treatment. There is evidence that physical exercise during cancer treatment ...

    Authors: Miranda J Velthuis, Anne M May, Ria AG Koppejan-Rensenbrink, Brigitte CM Gijsen, Eric van Breda, G Ardine de Wit, Carin D Schröder, Evelyn M Monninkhof, Eline Lindeman, Elsken van der Wall and Petra HM Peeters
    Citation: BMC Cancer 2010 10:272
    Content type: Study protocol Published on:

  23. Activation of telomerase resulting from deregulated hTERT expression is a key event during high-risk human papillomavirus (hrHPV)-induced cervical carcinogenesis. In the present study we examined hTERT promote...

    Authors: Jillian de Wilde, Jan M Kooter, Renée M Overmeer, Debbie Claassen-Kramer, Chris JLM Meijer, Peter JF Snijders and Renske DM Steenbergen
    Citation: BMC Cancer 2010 10:271
    Content type: Research article Published on:

  24. The aim of the present study was to analyze the expression of matrix metalloproteinase 9 (MMP9) in nasopharyngeal carcinoma (NPC) and its correlation with clinicopathologic features, including the survival of pat...

    Authors: Zhen Liu, Lixia Li, Zhixiong Yang, Weiren Luo, Xin Li, Huiling Yang, Kaitai Yao, Bin Wu and Weiyi Fang
    Citation: BMC Cancer 2010 10:270
    Content type: Research article Published on:

  25. Isothiocyanates are natural compounds found in consumable cruciferous vegetables. They have been shown to inhibit chemical carcinogenesis by a wide variety of chemical carcinogens in animal models. Recent stud...

    Authors: Xiang Wu, Yu Zhu, Huiqin Yan, Boning Liu, Ying Li, Qinghua Zhou and Ke Xu
    Citation: BMC Cancer 2010 10:269
    Content type: Research article Published on:

  26. High-grade gliomas have poor prognosis, requiring aggressive treatment. The aim of this study is to explore mitotic and centrosomal dysregulation in gliomas, which may provide novel targets for treatment.

    Authors: Joon-Khim Loh, Ann-Shung Lieu, Chia-Hua Chou, Fang-Yi Lin, Chia-Hung Wu, Sheng-Long Howng, Chung-Ching Chio and Yi-Ren Hong
    Citation: BMC Cancer 2010 10:268
    Content type: Research article Published on:

  28. Ethyl carbamate (EC) is a multi-site carcinogen in experimental animals and probably carcinogenic to humans (IARC group 2A). Traces of EC below health-relevant ranges naturally occur in several fermented foods...

    Authors: Dirk W Lachenmeier, Maria CP Lima, Ian CC Nóbrega, José AP Pereira, Florence Kerr-Corrêa, Fotis Kanteres and Jürgen Rehm
    Citation: BMC Cancer 2010 10:266
    Content type: Research article Published on:

  29. Melanoma is the most deadly form of skin cancer without effective treatment. Methylthioadenosine (MTA) is a naturally occurring nucleoside with differential effects on normal and transformed cells. MTA has bee...

    Authors: Pedro Andreu-Pérez, Javier Hernandez-Losa, Teresa Moliné, Rosa Gil, Judit Grueso, Anna Pujol, Javier Cortés, Matias A Avila and Juan A Recio
    Citation: BMC Cancer 2010 10:265
    Content type: Research article Published on:

  30. Malignant degeneration in association with orthopaedic implants is a known but rare complication. To our knowledge, no case of osseous malignant fibrous histiocytoma after anterior cruciate ligament reconstruc...

    Authors: Turgay Efe, Thomas J Heyse, Markus D Schofer, Susanne Fuchs-Winkelmann, Peter Rexin and Jan Schmitt
    Citation: BMC Cancer 2010 10:264
    Content type: Case report Published on:

  31. Stromal-epithelial interactions mediate breast development, and the initiation and progression of breast cancer. In the present study, we developed 3-dimensional (3D) in vitro models to study breast cancer tis...

    Authors: Silva Krause, Maricel V Maffini, Ana M Soto and Carlos Sonnenschein
    Citation: BMC Cancer 2010 10:263
    Content type: Research article Published on:

  32. MicroRNA (miRNA) signatures are not only found in cancer tissue but also in blood of cancer patients. Specifically, miRNA detection in blood offers the prospect of a non-invasive analysis tool.

    Authors: Petra Leidinger, Andreas Keller, Anne Borries, Jörg Reichrath, Knuth Rass, Sven U Jager, Hans-Peter Lenhof and Eckart Meese
    Citation: BMC Cancer 2010 10:262
    Content type: Research article Published on:

  33. Dendritic Cells (DC) are potent antigen presenting cells with the ability to prime naïve T cells and convert them to cytotoxic T-lymphocytes (CTL). We evaluated the capability of autologous DCs transfected wit...

    Authors: Mehran Gholamin, Omeed Moaven, Moein Farshchian, Mahmoud Mahmoudi, Mojtaba Sankian, Bahram Memar, Mohammad Naser Forghani, Reza Malekzadeh, Mohammad Taghi Rajabi-Mashhadi and Mohammad Reza Abbaszadegan
    Citation: BMC Cancer 2010 10:261
    Content type: Research article Published on:

  34. Prognostic factors in malignant melanoma are currently based on clinical data and morphologic examination. Other prognostic features, however, which are not yet used in daily practice, might add important info...

    Authors: Valcinir Bedin, Randall L Adam, Bianca CS de Sá, Gilles Landman and Konradin Metze
    Citation: BMC Cancer 2010 10:260
    Content type: Research article Published on:

  35. Cervical cancer represents an important global public health problem. It is the 2nd most common cancer among women worldwide. Human Papillomavirus (HPV) infection is now well-established as a necessary cause of i...

    Authors: Luciano Mariani, Núria Monfulleda, Laia Alemany, Enrico Vizza, Ferdinando Marandino, Amina Vocaturo, Maria Benevolo, Beatriz Quirós, Belén Lloveras, Jo Ellen Klaustermeier, Wim Quint, Silvia de Sanjosé and Fs Xavier Bosch
    Citation: BMC Cancer 2010 10:259
    Content type: Research article Published on:

  36. Longstanding evidence implicates an inadequate diet as a key factor in the onset and progression of prostate cancer. The purpose herein was to discover, validate and characterize functional biomarkers of dieta...

    Authors: David Cervi, Brian Pak, Natalie A Venier, Linda M Sugar, Robert K Nam, Neil E Fleshner, Laurence H Klotz and Vasundara Venkateswaran
    Citation: BMC Cancer 2010 10:258
    Content type: Research article Published on:

  37. Since 1999, patients presenting with brain metastases (BM) from breast cancer (BC) are treated in our institution with a carmustine (BCNU) - methotrexate (MTX) combination. We report here our clinical experien...

    Authors: William Jacot, Marie-Cécile Gerlotto-Borne, Simon Thezenas, Stéphane Pouderoux, Sylvain Poujol, Mahdi About and Gilles Romieu
    Citation: BMC Cancer 2010 10:257
    Content type: Research article Published on:

  38. The immune system plays an important role in the multifactorial biologic system during the development of neoplasias. However, the involvement of the inflammatory response in the promotion/control of malignant...

    Authors: Alessandra Estrela-Lima, Márcio SS Araújo, João M Costa-Neto, Andréa Teixeira-Carvalho, Stella M Barrouin-Melo, Sergio V Cardoso, Olindo A Martins-Filho, Rogéria Serakides and Geovanni D Cassali
    Citation: BMC Cancer 2010 10:256
    Content type: Research article Published on:

  41. Human Disabled-2 (DAB2), is a multi-function signalling molecule that it is frequently down-regulated in human cancers. We aimed to investigate the possible tumour suppressor effect of DAB2 in nasopharyngeal c...

    Authors: Joanna H Tong, David C Ng, Shuk L Chau, Ken K So, Patrick P Leung, Tin L Lee, Raymond W Lung, Michael W Chan, Anthony W Chan, Kwok W Lo and Ka F To
    Citation: BMC Cancer 2010 10:253
    Content type: Research article Published on:

  42. The combination of bevacizumab and irinotecan is a new chemotherapy protocol increasingly used for recurrent malignant glioma. Results from phase II trials suggest this drug combination is beneficial to patien...

    Authors: Tao Xu, Juxiang Chen, Yicheng Lu and Johannes EA Wolff
    Citation: BMC Cancer 2010 10:252
    Content type: Research article Published on:

  43. Most individuals who died of trauma were found to harbour microscopic primary cancers at autopsies. Surgical excision of the primary tumour, unfortunately, seems to disturb tumour dormancy in over half of all ...

    Authors: Tibor Bakács and Jitendra N Mehrishi
    Citation: BMC Cancer 2010 10:251
    Content type: Hypothesis Published on:

  44. Methotrexate is a chemotherapeutic drug that is used in therapy of a wide variety of cancers. The efficiency of treatment with this drug is compromised by the appearance of resistance. Combination treatments o...

    Authors: Nuria Mencía, Elisabet Selga, Isabel Rico, M Cristina de Almagro, Xenia Villalobos, Sara Ramirez, Jaume Adan, Jose L Hernández, Véronique Noé and Carlos J Ciudad
    Citation: BMC Cancer 2010 10:250
    Content type: Research article Published on:

  45. The FUS-DDIT3 fusion oncogene encodes an abnormal transcription factor that has a causative role in the development of myxoid/round-cell liposarcomas (MLS/RCLS). We have previously identified FLT1 (VEGFR1) as a c...

    Authors: Mattias K Andersson, Melker Göransson, Anita Olofsson, Carola Andersson and Pierre Åman
    Citation: BMC Cancer 2010 10:249
    Content type: Research article Published on:

  47. Various biomarkers for prediction of distant metastasis in lymph-node negative breast cancer have been described; however, predictive biomarkers for patients with lymph-node positive (LNP) disease in the conte...

    Authors: Dimo Dietrich, Manuel Krispin, Jörn Dietrich, Anne Fassbender, Jörn Lewin, Nadia Harbeck, Manfred Schmitt, Serenella Eppenberger-Castori, Vincent Vuaroqueaux, Frédérique Spyratos, John A Foekens, Ralf Lesche and John WM Martens
    Citation: BMC Cancer 2010 10:247
    Content type: Research article Published on:

  49. Angiogenesis plays an important role in the development and progression of tumors. Kallistatin exerts anti-angiogenic and anti-inflammatory activities that may be effective in inhibiting tumor metastasis. We i...

    Authors: Ai-Li Shiau, Min-Li Teo, Shin-Yao Chen, Chrong-Reen Wang, Jeng-Long Hsieh, Meng-Ya Chang, Chih-Jui Chang, Julie Chao, Lee Chao, Chao-Liang Wu and Che-Hsin Lee
    Citation: BMC Cancer 2010 10:245
    Content type: Research article Published on:

  50. Human seminoma is classified as classical seminoma (SE) and spermatocytic seminoma (SS). Human SE is known to be more malignant and metastasizing more frequently than SS. Tumor angiogenesis is highly related w...

    Authors: Jong-Hyuk Kim, Chi-Ho Yu, Ji-Young Yhee, Keum-Soon Im, Na-Hyun Kim and Jung-Hyang Sur
    Citation: BMC Cancer 2010 10:243
    Content type: Research article Published on:

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