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  1. Soy consumption is associated with a lower incidence of colon cancer which is believed to be mediated by one of its of components, genistein. Genistein may inhibit cancer progression by inducing apoptosis or i...

    Authors: Wentao Qi, Christopher R Weber, Kaarin Wasland and Suzana D Savkovic
    Citation: BMC Cancer 2011 11:219
    Content type: Research article Published on:

  2. Prognostic factors in predicting occult lymph node metastasis in patients with head and neck squamous-cell carcinoma (HNSCC) are necessary to improve the results of the sentinel lymph node procedure in this tu...

    Authors: Gerhard F Huber, Lena Züllig, Alex Soltermann, Matthias Roessle, Nicole Graf, Stephan K Haerle, Gabriela Studer, Wolfram Jochum, Holger Moch and Sandro J Stoeckli
    Citation: BMC Cancer 2011 11:217
    Content type: Research article Published on:

  3. We previously demonstrated that extracapsular invasion (ECI) at a metastatic sentinel node was significantly associated with the presence of positive non-sentinel nodes in patients with breast cancer. However,...

    Authors: Takaaki Fujii, Yuichi Tabe, Reina Yajima, Satoru Yamaguchi, Soichi Tsutsumi, Takayuki Asao and Hiroyuki Kuwano
    Citation: BMC Cancer 2011 11:216
    Content type: Research article Published on:

  4. Identification of predictive markers of response to treatment is a major objective in breast cancer. A major problem in clinical sampling is the variability of RNA templates, requiring accurate management of t...

    Authors: Patricia de Cremoux, Fabien Valet, David Gentien, Jacqueline Lehmann-Che, Véronique Scott, Carine Tran-Perennou, Catherine Barbaroux, Nicolas Servant, Sophie Vacher, Brigitte Sigal-Zafrani, Marie-Christine Mathieu, Philippe Bertheau, Jean-Marc Guinebretière, Bernard Asselain, Michel Marty and Frédérique Spyratos
    Citation: BMC Cancer 2011 11:215
    Content type: Research article Published on:

  5. Cyclooxygenase-2 overexpression is associated with poor outcome and resistance to platinum-based chemotherapy in ovarian cancer. We evaluated the antitumor activity and safety of the combination carboplatin pl...

    Authors: Francesco Legge, Amelia Paglia, Marco D'Asta, Gilda Fuoco, Giovanni Scambia and Gabriella Ferrandina
    Citation: BMC Cancer 2011 11:214
    Content type: Research article Published on:

  6. Chemokines and chemokine receptors are major actors of leukocytes trafficking and some have been shown to play an important role in cancer metastasis. Chemokines CCL19, CCL20 and CCL21 and their receptors CCR6...

    Authors: Philippe A Cassier, Isabelle Treilleux, Thomas Bachelot, Isabelle Ray-Coquard, Nathalie Bendriss-Vermare, Christine Ménétrier-Caux, Olivier Trédan, Sophie Goddard-Léon, Jean-Jacques Pin, Hervé Mignotte, Clarisse Bathélémy-Dubois, Christophe Caux, Serge Lebecque and Jean-Yves Blay
    Citation: BMC Cancer 2011 11:213
    Content type: Research article Published on:

  7. Heparin affin regulatory peptide (HARP), also called pleiotrophin, is a heparin-binding, secreted factor that is overexpressed in several tumours and associated to tumour growth, angiogenesis and metastasis. T...

    Authors: Yamina Hamma-Kourbali, Oya Bermek, Isabelle Bernard-Pierrot, Racha Karaky, Dominique Martel-Renoir, Sophie Frechault, José Courty and Jean Delbé
    Citation: BMC Cancer 2011 11:212
    Content type: Research article Published on:

  8. Frequent failure and severe side effects of current sarcoma therapy warrants new therapeutic approaches. The small-molecule MDM2 antagonist Nutlin-3a activates the p53 pathway and efficiently induces apoptosis...

    Authors: Hege O Ohnstad, Erik B Paulsen, Paul Noordhuis, Marianne Berg, Ragnhild A Lothe, Lyubomir T Vassilev and Ola Myklebost
    Citation: BMC Cancer 2011 11:211
    Content type: Research article Published on:

  10. Osteosarcoma (OS) is a bone malignancy which occurs primarily in adolescents. Since it occurs during a period of rapid growth, genes important in bone formation and growth are plausible modifiers of risk. Gene...

    Authors: Lisa Mirabello, Kai Yu, Sonja I Berndt, Laurie Burdett, Zhaoming Wang, Salma Chowdhury, Kedest Teshome, Arinze Uzoka, Amy Hutchinson, Tom Grotmol, Chester Douglass, Richard B Hayes, Robert N Hoover and Sharon A Savage
    Citation: BMC Cancer 2011 11:209
    Content type: Research article Published on:

  12. Mifepristone (MF) has been largely used in reproductive medicine due to its capacity to modulate the progesterone receptor (PR). The study of MF has been expanded to the field of oncology; yet it remains uncle...

    Authors: Chelsea R Tieszen, Alicia A Goyeneche, BreeAnn N Brandhagen, Casey T Ortbahn and Carlos M Telleria
    Citation: BMC Cancer 2011 11:207
    Content type: Research article Published on:

  14. We sought to evaluate prognostic factors affecting overall survival (OS), and to investigate the role of palliative chemotherapy using propensity score-based weighting, in patients with advanced small bowel ad...

    Authors: Dong Hoe Koo, Sung-Cheol Yun, Yong Sang Hong, Min-Hee Ryu, Jae-Lyun Lee, Heung-Moon Chang, Baek-Yeol Ryoo, Yoon-Koo Kang and Tae Won Kim
    Citation: BMC Cancer 2011 11:205
    Content type: Research article Published on:

  15. Capillary leak syndrome (CLS) is a rare condition characterized by recurrent episodes of generalized edema and severe hypotension associated with hypoproteinemia. Interleukin-11 (IL-11) is a promising therapeu...

    Authors: Wang Kai-Feng, Pan Hong-Ming, Lou Hai-Zhou, Shen Li-Rong and Zhu Xi-Yan
    Citation: BMC Cancer 2011 11:204
    Content type: Case report Published on:

  16. Metastatic melanoma represents a major clinical problem. Its incidence continues to rise in western countries and there are currently no curative treatments. While mutation of the P53 tumour suppressor gene is a ...

    Authors: Kelly A Avery-Kiejda, Nikola A Bowden, Amanda J Croft, Lyndee L Scurr, Carla F Kairupan, Katie A Ashton, Bente A Talseth-Palmer, Helen Rizos, Xu D Zhang, Rodney J Scott and Peter Hersey
    Citation: BMC Cancer 2011 11:203
    Content type: Research article Published on:

  17. Transarterial chemoembolization (TACE) therapy is an effective locoregional treatment in hepatocellular cancer (HCC) patients. For early modification of therapy, markers predicting therapy response are urgentl...

    Authors: Nikolaus Kohles, Dorothea Nagel, Dietrich Jüngst, Jürgen Durner, Petra Stieber and Stefan Holdenrieder
    Citation: BMC Cancer 2011 11:202
    Content type: Research article Published on:

  18. Histiocytic malignancies in both humans and dogs are rare and poorly understood. While canine histiocytic sarcoma (HS) is uncommon in the general domestic dog population, there is a strikingly high incidence i...

    Authors: Benoit Hedan, Rachael Thomas, Alison Motsinger-Reif, Jerome Abadie, Catherine Andre, John Cullen and Matthew Breen
    Citation: BMC Cancer 2011 11:201
    Content type: Research article Published on:

  20. Amplification of 3q26 is one of the most frequent genetic alterations in many human malignancies. Recently, we isolated a novel oncogene eIF-5A2 within the 3q26 region. Functional study has demonstrated the oncog...

    Authors: Muhan Chen, Jian-Dong Huang, Hong Kui Deng, Suisui Dong, Wen Deng, Sze Lan Tsang, Michael SY Huen, Leilei Chen, Tong Zan, Gui-Xia Zhu and Xin-Yuan Guan
    Citation: BMC Cancer 2011 11:199
    Content type: Research article Published on:

  21. HIF-1 deficiency has marked effects on tumour glycolysis and growth. We therefore investigated the consequences of HIF-1 deficiency in mice, using the well established Hepa-1 wild-type (WT) and HIF-1β-deficien...

    Authors: Monika Golinska, Helen Troy, Yuen-Li Chung, Paul M McSheehy, Manuel Mayr, Xiaoke Yin, Lucy Ly, Kaye J Williams, Rachel E Airley, Adrian L Harris, John Latigo, Meg Perumal, Eric O Aboagye, David Perrett, Marion Stubbs and John R Griffiths
    Citation: BMC Cancer 2011 11:198
    Content type: Research article Published on:

  22. Repeat radiation is a rarely used treatment strategy that must be performed with caution. The efficacy and toxicity of a second curative radiotherapy series was investigated in cases of recurrent breast cancer.

    Authors: Arndt-Christian Müller, Franziska Eckert, Vanessa Heinrich, Michael Bamberg, Sara Brucker and Thomas Hehr
    Citation: BMC Cancer 2011 11:197
    Content type: Research article Published on:

  23. We aimed to investigate the prevalence and predictors of Complementary and Alternative Medicine (CAM) use among cancer patients and non-cancer volunteers, and to assess the knowledge of and attitudes toward CA...

    Authors: Kah Hoong Chang, Rachel Brodie, Mei Ann Choong, Karl J Sweeney and Michael J Kerin
    Citation: BMC Cancer 2011 11:196
    Content type: Research article Published on:

  24. Earlier studies have reported the production of histamine in colorectal cancers (CRCs). The effect of histamine is largely determined locally by the histamine receptor expression pattern. Recent evidence sugge...

    Authors: Zhengyu Fang, Wantong Yao, Yi Xiong, Jiana Li, Li Liu, Lei Shi, Wei Zhang, Chao Zhang, Liping Nie and Jun Wan
    Citation: BMC Cancer 2011 11:195
    Content type: Research article Published on:

  25. Major histocompatibility complex class I-related chain A and B (MICA/B) are two stress-inducible ligands that bind the immunoreceptor NKG2D and play an important role in mediating the cyotoxicity of NK and T c...

    Authors: Xiulong Xu, Geetha S Rao, Veronika Groh, Thomas Spies, Paolo Gattuso, Howard L Kaufman, Janet Plate and Richard A Prinz
    Citation: BMC Cancer 2011 11:194
    Content type: Research article Published on:

  26. Cancer patients routinely develop symptoms consistent with profound circadian disruption, which causes circadian disruption diminished quality of life. This study was initiated to determine the relationship be...

    Authors: James F Grutsch, Carol Ferrans, Patricia A Wood, Jovelyn Du-Quiton, Dinah Faith T Quiton, Justin L Reynolds, Christine M Ansell, Eun Young Oh, Mary Ann Daehler, Robert D Levin, Donald P Braun, Digant Gupta, Christopher G Lis and William JM Hrushesky
    Citation: BMC Cancer 2011 11:193
    Content type: Research article Published on:

  27. Breast cancer (BC) causes more deaths than any other cancer among women in Catalonia. Early detection has contributed to the observed decline in BC mortality. However, there is debate on the optimal screening ...

    Authors: Misericordia Carles, Ester Vilaprinyo, Francesc Cots, Aleix Gregori, Roger Pla, Rubén Román, Maria Sala, Francesc Macià, Xavier Castells and Montserrat Rue
    Citation: BMC Cancer 2011 11:192
    Content type: Research article Published on:

  28. Treatment of invasive breast cancer has an alarmingly high rate of failure because effective targets have not been identified. One potential target is mitochondrial generated reactive oxygen species (ROS) beca...

    Authors: Jorming Goh, Linda Enns, Soroosh Fatemie, Heather Hopkins, John Morton, Christina Pettan-Brewer and Warren Ladiges
    Citation: BMC Cancer 2011 11:191
    Content type: Research article Published on:

  29. Most patients with cancers of the nasal cavity or paranasal sinuses are candidates of radiation therapy either due incomplete resection or technical inoperability. Local control in this disease is dose depende...

    Authors: Alexandra D Jensen, Anna V Nikoghosyan, Christine Windemuth-Kieselbach, Jürgen Debus and Marc W Münter
    Citation: BMC Cancer 2011 11:190
    Content type: Study protocol Published on:

  30. L1 cell adhesion molecule (CD171) is expressed in many malignant tumors and its expression correlates with unfavourable outcome. It thus represents a target for tumor diagnosis and therapy. An earlier study co...

    Authors: Hilke Zander, Tamina Rawnaq, Max von Wedemeyer, Michael Tachezy, Miriam Kunkel, Gerrit Wolters, Maximilian Bockhorn, Melitta Schachner, Jakob R Izbicki and Jussuf Kaifi
    Citation: BMC Cancer 2011 11:189
    Content type: Research article Published on:

  31. Because of the late clinical presentation of biliary tract cancer (BTC), only 10% of patients are eligible for curative surgery. Even among those patients who have undergone curative surgery, most patients dev...

    Authors: Yun-Gyoo Lee, Sae-Won Han, Do-Youn Oh, Eui Kyu Chie, Jin-Young Jang, Seock-Ah Im, Tae-You Kim, Sun-Whe Kim, Sung Whan Ha and Yung-Jue Bang
    Citation: BMC Cancer 2011 11:188
    Content type: Research article Published on:

  32. Although gangliocytic paraganglioma (GP) has generally been regarded as a neuroendocrine tumor, its origin remains unclear. We therefore aimed to investigate the details of this disease by carefully analyzing ...

    Authors: Yoichiro Okubo, Megumi Wakayama, Tetsuo Nemoto, Kanako Kitahara, Haruo Nakayama, Kazutoshi Shibuya, Tomoyuki Yokose, Manabu Yamada, Kayoko Shimodaira, Daisuke Sasai, Takao Ishiwatari, Masaru Tsuchiya and Nobuyuki Hiruta
    Citation: BMC Cancer 2011 11:187
    Content type: Research article Published on:

  33. As a negative modulator of the canonical Wnt signaling pathway, Naked1 (NKD1) is widely expressed in many normal tissues. However, the expression pattern and clinicopathological significance of NKD1 in patient...

    Authors: Sheng Zhang, Yan Wang, Shun-Dong Dai and En-Hua Wang
    Citation: BMC Cancer 2011 11:186
    Content type: Research article Published on:

  34. Immunohistochemical detection of cold shock proteins is predictive for deleterious outcome in various malignant diseases. We recently described active secretion of a family member, denoted Y-box (YB) protein-1...

    Authors: Frank Tacke, Nicolas Kanig, Abdelaziz En-Nia, Thilo Kaehne, Christiane S Eberhardt, Victoria Shpacovitch, Christian Trautwein and Peter R Mertens
    Citation: BMC Cancer 2011 11:185
    Content type: Research article Published on:

  35. Glioblastoma (GBM) is a highly aggressive malignant primary brain tumor, characterized by rapid growth, diffuse infiltration of cells into both adjacent and remote brain regions, and a generalized resistance t...

    Authors: Barbara C Merk, Jennifer L Owens, Maria-Beatriz S Lopes, Corinne M Silva and Isa M Hussaini
    Citation: BMC Cancer 2011 11:184
    Content type: Research article Published on:

  36. β-Elemene, a compound found in an herb used in traditional Chinese medicine, has shown promising anti-cancer effects against a broad spectrum of tumors. The mechanism by which β-elemene kills cells remains unc...

    Authors: Jing Liu, Ye Zhang, Jinglei Qu, Ling Xu, Kezuo Hou, Jingdong Zhang, Xiujuan Qu and Yunpeng Liu
    Citation: BMC Cancer 2011 11:183
    Content type: Research article Published on:

  37. Long-term locoregional control in locally advanced squamous cell carcinoma of the head and neck (SCCHN) remains challenging. While recent years have seen various approaches to improve outcome by intensificatio...

    Authors: Alexandra D Jensen, Jürgen Krauss, Karin Potthoff, Almaz Desta, Gregor Habl, Athanasios Mavtratzas, Christine Windemuth-Kiesselbach, Jürgen Debus and Marc W Münter
    Citation: BMC Cancer 2011 11:182
    Content type: Study protocol Published on:

  38. This is a randomized, controlled trial of preoperative chemotherapy in patients undergoing surgery for oesophageal squamous cell carcinoma (OSCC). Patients were allocated to chemotherapy, consisting of 2-4 cyc...

    Authors: Jurjen J Boonstra, Tjebbe C Kok, Bas PL Wijnhoven, Mark van Heijl, Mark I van Berge Henegouwen, Fiebo JW ten Kate, Peter D Siersema, Winand NM Dinjens, Jan JB van Lanschot, Hugo W Tilanus and Ate van der Gaast
    Citation: BMC Cancer 2011 11:181
    Content type: Research article Published on:

  39. Stat3 is a cytokine- and growth factor-inducible transcription factor that regulates cell motility, migration, and invasion under normal and pathological situations, making it a promising target for cancer the...

    Authors: Zanobia A Syed, Weihong Yin, Kendall Hughes, Jennifer N Gill, Runhua Shi and John L Clifford
    Citation: BMC Cancer 2011 11:180
    Content type: Research article Published on:

  40. Weekly docetaxel has occasionally been used in the neoadjuvant to downstage breast cancer to reduce toxicity and possibly enhance quality of life. However, no studies have compared the standard three weekly re...

    Authors: Leslie G Walker, Jennifer M Eremin, Mark M Aloysius, Wichai Vassanasiri, Mary B Walker, Mohamed El-Sheemy, Ged Cowley, Jeanette Beer, Srila Samphao, Janice Wiseman, Jibril A Jibril, David Valerio, David J Clarke, Mujahid Kamal, Gerald W Thorpe, Karin Baria…
    Citation: BMC Cancer 2011 11:179
    Content type: Research article Published on:

  42. To assess the role of Thymidine Phosphorylase and β-tubulin III in clinical outcome of Chinese advanced gastric cancer patients receiving first-line capecitabine plus paclitaxel.

    Authors: Jing Gao, Ming Lu, Jing-wei Yu, Yan-yan Li and Lin Shen
    Citation: BMC Cancer 2011 11:177
    Content type: Research article Published on:

  43. Recent data in esophageal cancer suggests the variant allele of a single-nucleotide polymorphism (SNP) in XRCC1 may be associated with resistance to radiochemotherapy. However, this SNP has not been assessed in a...

    Authors: Harry H Yoon, Paul J Catalano, Kathleen M Murphy, Todd C Skaar, Santosh Philips, Mark Powell, Elizabeth A Montgomery, Michael J Hafez, Steven M Offer, Geoffrey Liu, Stephen J Meltzer, Xifeng Wu, Arlene A Forastiere, Al B Benson, Lawrence R Kleinberg and Michael K Gibson
    Citation: BMC Cancer 2011 11:176
    Content type: Research article Published on:

  44. Tazarotene-induced gene 1 (TIG1) is a retinoid-inducible type II tumour suppressor gene. The B isoform of TIG1 (TIG1B) inhibits growth and invasion of cancer cells. Expression of TIG1B is frequently downregula...

    Authors: Chang-Chieh Wu, Fu-Ming Tsai, Rong-Yaun Shyu, Ya-Ming Tsai, Chun-Hua Wang and Shun-Yuan Jiang
    Citation: BMC Cancer 2011 11:175
    Content type: Research article Published on:

  45. The DNA repair gene Ku70, an important member of non-homologous end-joining repair system, is thought to play an important role in the repairing of DNA double strand breaks. It is known that defects in double str...

    Authors: Mei-Due Yang, Hwei-Chung Wang, Wen-Shin Chang, Chia-Wen Tsai and Da-Tian Bau
    Citation: BMC Cancer 2011 11:174
    Content type: Research article Published on:

  46. MAP2K4 is a putative tumor and metastasis suppressor gene frequently found to be deleted in various cancer types. We aimed to conduct a comprehensive analysis of this gene to assess its involvement in ovarian ca...

    Authors: Sally J Davis, David YH Choong, Manasa Ramakrishna, Georgina L Ryland, Ian G Campbell and Kylie L Gorringe
    Citation: BMC Cancer 2011 11:173
    Content type: Research article Published on:

  47. A subset of lung cancer patients harbour EGFR somatic mutations in their tumours and are candidates for treatment with EGFR tyrosine kinase inhibitors. In a few cases EGFR mutations have also been found in the ge...

    Authors: Irene Centeno, Pilar Blay, Iñigo Santamaría, Aurora Astudillo, Ana S Pitiot, Fernando G Osorio, Patricia González-Arriaga, Fernando Iglesias, Primitiva Menéndez, Adonina Tardón, Jose M Freije and Milagros Balbín
    Citation: BMC Cancer 2011 11:172
    Content type: Research article Published on:

  48. Of all female genital tract tumors, 1-3% are stromal malignancies. In 8-10% of cases, these are represented by Müllerian adenosarcoma an extremely rare tumor characterized by a stromal component of usually low...

    Authors: Tito S Patrelli, Enrico M Silini, Salvatore Gizzo, Roberto Berretta, Laura Franchi, Elena Thai, Adolf Lukanovic, Giovanni B Nardelli and Alberto Bacchi Modena
    Citation: BMC Cancer 2011 11:171
    Content type: Case report Published on:

  49. Celastrol is an active ingredient of the traditional Chinese medicinal plant Tripterygium Wilfordii, which exhibits significant antitumor activity in different cancer models in vitro and in vivo; however, the lac...

    Authors: Guozhu Chen, Xuhui Zhang, Ming Zhao, Yan Wang, Xiang Cheng, Di Wang, Yuanji Xu, Zhiyan Du and Xiaodan Yu
    Citation: BMC Cancer 2011 11:170
    Content type: Research article Published on:

  50. Mesothelioma is an aggressive neoplasm with few effective treatments, one being cytoreductive surgery. We previously described a test, based on differential expression levels of four genes, to predict clinical...

    Authors: Gavin J Gordon, Raphael Bueno and David J Sugarbaker
    Citation: BMC Cancer 2011 11:169
    Content type: Research article Published on:

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