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  1. The CD44 cell adhesion molecule is aberrantly expressed in many breast tumors and has been implicated in the metastatic process as well as in the putative cancer stem cell (CSC) compartment. We aimed to invest...

    Authors: Eleonor Olsson, Gabriella Honeth, Pär-Ola Bendahl, Lao H Saal, Sofia Gruvberger-Saal, Markus Ringnér, Johan Vallon-Christersson, Göran Jönsson, Karolina Holm, Kristina Lövgren, Mårten Fernö, Dorthe Grabau, Åke Borg and Cecilia Hegardt
    Citation: BMC Cancer 2011 11:418
    Content type: Research article Published on:

  2. Cyclin D1 is a well-characterised cell cycle regulator with established oncogenic capabilities. Despite these properties, studies report contrasting links to tumour aggressiveness. It has previously been shown...

    Authors: Nicholas P Tobin, Andrew H Sims, Katja L Lundgren, Sophie Lehn and Göran Landberg
    Citation: BMC Cancer 2011 11:417
    Content type: Research article Published on:

  3. Cancer/testis antigens are considered potential targets for immunotherapy due to their tumor-associated expression pattern. Although recent studies have demonstrated high expression of CT45 in classical Hodgki...

    Authors: Riguel J Inaoka, Achim A Jungbluth, Otávio CG Baiocchi, Mariane CG Assis, Nicole C Hanson, Denise Frosina, Jodie Tassello, Adriana B Bortoluzzo, Antonio C Alves and Gisele WB Colleoni
    Citation: BMC Cancer 2011 11:416
    Content type: Research article Published on:

  4. In Australia, breast cancer is the most common cancer affecting Australian women. Inequalities in clinical and psychosocial outcomes have existed for some time, affecting particularly women from rural areas an...

    Authors: Philippa H Youl, Peter D Baade, Joanne F Aitken, Suzanne K Chambers, Gavin Turrell, Christopher Pyke and Jeffrey Dunn
    Citation: BMC Cancer 2011 11:415
    Content type: Study protocol Published on:

  5. The objective of this study is to assess the clinical significance and prognostic impact of extramural metastasis in colorectal carcinoma and establish an optimal categorization in the staging system.

    Authors: Hai-Bo Qiu, Gong Chen, Rajiv P Keshari, Hui-Yan Luo, Wang Fang, Miao-Zhen Qiu, Zhi-Wei Zhou and Rui-Hua Xu
    Citation: BMC Cancer 2011 11:414
    Content type: Research article Published on:

  6. The molecular mechanisms involved in the development and progression of clear cell renal cell carcinomas (ccRCCs) are poorly understood. The objective of this study was to analyze the expression of dual-specif...

    Authors: Song Wu, Yong Wang, Liang Sun, Zhiling Zhang, Zhimao Jiang, Zike Qin, Hui Han, Zhuowei Liu, Xianxin Li, Aifa Tang, Yaoting Gui, Zhiming Cai and Fangjian Zhou
    Citation: BMC Cancer 2011 11:413
    Content type: Research article Published on:

  7. Cells of most human cancers have supernumerary centrosomes. To enable an accurate chromosome segregation and cell division, these cells developed a yet unresolved molecular mechanism, clustering their extra ce...

    Authors: Asher Castiel, Leonid Visochek, Leonid Mittelman, Françoise Dantzer, Shai Izraeli and Malka Cohen-Armon
    Citation: BMC Cancer 2011 11:412
    Content type: Research article Published on:

  8. The Aurora kinase family members, Aurora-A, -B and -C, are involved in the regulation of mitosis, and alterations in their expression are associated with cell malignant transformation. To date no information o...

    Authors: Enke Baldini, Yannick Arlot-Bonnemains, Salvatore Sorrenti, Caterina Mian, Maria R Pelizzo, Enrico De Antoni, Silvio Palermo, Stefania Morrone, Susi Barollo, Angela Nesca, Costanzo G Moretti, Massimino D'Armiento and Salvatore Ulisse
    Citation: BMC Cancer 2011 11:411
    Content type: Research article Published on:

  11. The aim of this study was to assess the extent of knowledge of primary health care (PHC) patients about colorectal cancer (CRC), their attitudes toward population-based screening for this disease and gender di...

    Authors: Maria Ramos, Maria Llagostera, Magdalena Esteva, Elena Cabeza, Xavier Cantero, Manel Segarra, Maria Martín-Rabadán, Guillem Artigues, Maties Torrent, Joana Maria Taltavull, Joana Maria Vanrell, Mercè Marzo and Joan Llobera
    Citation: BMC Cancer 2011 11:408
    Content type: Research article Published on:

  12. Osteosarcoma is the most common primary bone malignancy in childhood and adolescence. However, it is very rare in children under 5 years of age. Although studies in young children are limited in number, they a...

    Authors: Maud AM Guillon, Pierre MJ Mary, Laurence Brugière, Perrine Marec-Bérard, Hélène D Pacquement, Claudine Schmitt, Jean-Marc Guinebretière and Marie-Dominique P Tabone
    Citation: BMC Cancer 2011 11:407
    Content type: Research article Published on:

  13. Epidermal growth factor receptor (EGFR) and its downstream factors KRAS and BRAF are mutated in several types of cancer, affecting the clinical response to EGFR inhibitors. Mutations in the EGFR kinase domain pre...

    Authors: Emma Borràs, Ismael Jurado, Imma Hernan, María José Gamundi, Miguel Dias, Isabel Martí, Begoña Mañé, Àngels Arcusa, José AG Agúndez, Miguel Blanca and Miguel Carballo
    Citation: BMC Cancer 2011 11:406
    Content type: Research article Published on:

  14. The neural transcription factor SOX11 has been described as a prognostic marker in epithelial ovarian cancers (EOC), however its role in individual histological subtypes and tumour grade requires further clari...

    Authors: Sandra Sernbo, Elin Gustavsson, Donal J Brennan, William M Gallagher, Elton Rexhepaj, Frida Rydnert, Karin Jirström, Carl AK Borrebaeck and Sara Ek
    Citation: BMC Cancer 2011 11:405
    Content type: Research article Published on:

  15. Febrile neutropenia (FN) occurs following myelosuppressive chemotherapy and is associated with morbidity, mortality, costs, and chemotherapy reductions and delays. Granulocyte colony-stimulating factors (G-CSF...

    Authors: Katy L Cooper, Jason Madan, Sophie Whyte, Matt D Stevenson and Ron L Akehurst
    Citation: BMC Cancer 2011 11:404
    Content type: Research article Published on:

  16. To assess prognostic and predictive effects of clinical and biochemical factors in our published randomized study of a weekly low dose (metronomic arm) versus a conventional dosage of zoledronic acid (conventi...

    Authors: Xinmin Zhao, Xiaofeng Xu, Qunling Zhang, Zhen Jia, Si Sun, Jian Zhang, Biyun Wang, Zhonghua Wang and Xichun Hu
    Citation: BMC Cancer 2011 11:403
    Content type: Research article Published on:

  18. Official descriptive data from France showed a strong increase in breast-cancer incidence between 1980 to 2005 without a corresponding change in breast-cancer mortality. This study quantifies the part of incid...

    Authors: Bernard Junod, Per-Henrik Zahl, Robert M Kaplan, Jørn Olsen and Sander Greenland
    Citation: BMC Cancer 2011 11:401
    Content type: Research article Published on:

  20. P21(WAF1/Cip1) binds to cyclin-dependent kinase complexes and inhibits their activities. It was originally described as an inhibitor of cancer cell proliferation. However, many recent studies have shown that p21 ...

    Authors: Xi Xia, Quanfu Ma, Xiao Li, Teng Ji, Pingbo Chen, Hongbin Xu, Kezhen Li, Yong Fang, Danhui Weng, Yanjie Weng, Shujie Liao, Zhiqiang Han, Ronghua Liu, Tao Zhu, Shixuan Wang, Gang Xu…
    Citation: BMC Cancer 2011 11:399
    Content type: Research article Published on:

  21. Development of the hepatitis B virus (HBV) rtA181T/sW172* mutant could occur during prolonged lamivudine (LAM) therapy, conferring cross resistance to adefovir. Recent studies demonstrated an increased oncogen...

    Authors: Chau-Ting Yeh, Tiffany Chen, Chao-Wei Hsu, Yi-Cheng Chen, Ming-Wei Lai, Kung-Hao Liang and Tse-Ching Chen
    Citation: BMC Cancer 2011 11:398
    Content type: Research article Published on:

  22. 14-3-3Æ¡ is an intracellular, phosphoserine binding protein and proposed to be involved in tumorigenesis. However, the expression dynamics of 14-3-3Æ¡ and its clinicopathological/prognostic significance in human...

    Authors: Wei-hua Zhou, Fang Tang, Jie Xu, Xing Wu, Zhi-ying Feng, Hai-gang Li, Dong-jun Lin, Chun-kui Shao and Quentin Liu
    Citation: BMC Cancer 2011 11:397
    Content type: Research article Published on:

  24. To access the prognostic significance of HER-2 overexpression, the effect of trastuzumab and the cause of death in patients with brain metastases (BM) from breast cancer (BC).

    Authors: Romuald Le Scodan, Ludivine Jouanneau, Christophe Massard, Maya Gutierrez, Youlia Kirova, Pascal Cherel, Julie Gachet, Alain Labib and Emmanuelle Mouret-Fourme
    Citation: BMC Cancer 2011 11:395
    Content type: Research article Published on:

  25. Multiple myeloma (MM) is a fatal malignancy ranking second in prevalence among hematological tumors. Continuous efforts are being made to develop innovative and more effective treatments. The preclinical evalu...

    Authors: Leonardo Mirandola, Yuefei Yu, Marjorie R Jenkins, Raffaella Chiaramonte, Everardo Cobos, Constance M John and Maurizio Chiriva-Internati
    Citation: BMC Cancer 2011 11:394
    Content type: Research article Published on:

  26. Lung cancer is the leading cause of cancer-related deaths worldwide. Early detection is considered critical for lung cancer treatment. MicroRNAs (miRNAs) have shown promise as diagnostic and prognostic indicat...

    Authors: Wangyu Zhu, XiaoGuang Liu, JianYing He, DongDong Chen, YanYan Hunag and Yong Kui Zhang
    Citation: BMC Cancer 2011 11:393
    Content type: Research article Published on:

  27. Inducible costimulator (ICOS), a costimulatory molecular of the CD28 family, provides positive signal to enhance T cell proliferation. Its abnormal expression can disturb the immune response and entail an increa...

    Authors: Fengyan Xu, Dalin Li, Qiujin Zhang, Zhenkun Fu, Jie Zhang, Weiguang Yuan, Shuang Chen, Da Pang and Dianjun Li
    Citation: BMC Cancer 2011 11:392
    Content type: Research article Published on:

  30. Exercise interventions during adjuvant cancer therapy have been shown to increase functional capacity, relieve fatigue and distress and may assist rates of chemotherapy completion. These studies have been limi...

    Authors: Melissa J Newton, Sandi C Hayes, Monika Janda, Penelope M Webb, Andreas Obermair, Elizabeth G Eakin, David Wyld, Louisa G Gordon and Vanessa L Beesley
    Citation: BMC Cancer 2011 11:389
    Content type: Research article Published on:

  31. Recently it has been shown that radiation induces migration of glioma cells and facilitates a further spread of tumor cells locally and systemically. The aim of this study was to evaluate whether radiotherapy ...

    Authors: Anja C Pickhard, Johanna Margraf, Andreas Knopf, Thomas Stark, Guido Piontek, Carolin Beck, Anne-Laure Boulesteix, Elias Q Scherer, Steffi Pigorsch, Jürgen Schlegel, Wolfgang Arnold and Rudolf Reiter
    Citation: BMC Cancer 2011 11:388
    Content type: Research article Published on:

  32. Fatigue among cancer patients has often been reported in the literature; however, great variations have been documented, ranging from 15% to 90%, probably due to the lack of a widely accepted definition and es...

    Authors: En-Tien Yeh, Shu-Chuen Lau, Wei-Ju Su, Duu-Jian Tsai, Ying-Yueh Tu and Yuen-Liang Lai
    Citation: BMC Cancer 2011 11:387
    Content type: Research article Published on:

  33. Sentinel lymph node (SLN) biopsy has been used to assess patients with papillary thyroid carcinoma (PTC). To achieve its full potential the rate of SLN identification must be as close to 100 percent as possibl...

    Authors: Ou Huang, WeiLi Wu, OuChen Wang, Jie You, Quan Li, DuPing Huang, XiaoQu Hu, JinMiao Qu, Cun Jin, YouQun Xiang, Kai Yang, ShuMei Zhou, XueMin Chen, YiFei Pan, GuiLong Guo and XiaoHua Zhang
    Citation: BMC Cancer 2011 11:386
    Content type: Research article Published on:

  34. This phase II study assessed the response rate and toxicity profile of weekly paclitaxel and capecitabine in patients with metastatic or recurrent squamous cell carcinoma of the esophagus (SCCE)

    Authors: Tak Yun, Ji-Youn Han, Jin Soo Lee, Hyun Lee Choi, Hyae Young Kim, Byung-Ho Nam and Heung Tae Kim
    Citation: BMC Cancer 2011 11:385
    Content type: Research article Published on:

  36. The debate continues as to whether younger women who present with breast cancer have a more aggressive form of disease and a worse prognosis. The objectives of this study were to determine the incidence of bre...

    Authors: Elrasheid AH Kheirelseid, Jennifer ME Boggs, Catherine Curran, Ronan W Glynn, Cara Dooley, Karl J Sweeney and Michael J Kerin
    Citation: BMC Cancer 2011 11:383
    Content type: Research article Published on:

  38. Serum protein profiles have been investigated frequently to discover early biomarkers for breast cancer. So far, these studies used biological samples collected at or after diagnosis. This may limit these studies...

    Authors: Annemieke WJ Opstal-van Winden, Esmeralda JM Krop, Monica H Kåredal, Marie-Christine W Gast, Christian H Lindh, Marina C Jeppsson, Bo AG Jönsson, Diederick E Grobbee, Petra HM Peeters, Jos H Beijnen, Carla H van Gils and Roel CH Vermeulen
    Citation: BMC Cancer 2011 11:381
    Content type: Research article Published on:

  39. Uveal melanoma (UM) is a rare eye tumor. There are two classes of UM, which can be discriminated by the chromosome 3 status or global mRNA expression profile. Metastatic progression is predominantly originated...

    Authors: Lisa C Neumann, Andreas Weinhäusel, Stefanie Thomas, Bernhard Horsthemke, Dietmar R Lohmann and Michael Zeschnigk
    Citation: BMC Cancer 2011 11:380
    Content type: Research article Published on:

  40. The Internet can increase access to psychosocial care for breast cancer survivors through online support groups. This study will test a novel prosocial online group that emphasizes both opportunities for getti...

    Authors: Stephen J Lepore, Joanne S Buzaglo, Morton A Lieberman, Mitch Golant and Adam Davey
    Citation: BMC Cancer 2011 11:379
    Content type: Study protocol Published on:

  41. 14-3-3 proteins are a family of highly conserved proteins that are involved in a wide range of cellular processes. Recent evidence indicates that some of these proteins have oncogenic activity and that they ma...

    Authors: Vijayababu M Radhakrishnan, Charles W Putnam, Wenqing Qi and Jesse D Martinez
    Citation: BMC Cancer 2011 11:378
    Content type: Research article Published on:

  42. Epidemiological evidence suggests that moderately elevated levels of circulating insulin-like growth factor-I (IGF-I) are associated with increased risk of breast cancer in women. How circulating IGF-I may pro...

    Authors: Robert K Dearth, Isere Kuiatse, Yu-Fen Wang, Lan Liao, Susan G Hilsenbeck, Powel H Brown, Jianming Xu and Adrian V Lee
    Citation: BMC Cancer 2011 11:377
    Content type: Research article Published on:

  43. Populations having lower socioeconomic status, as well as ethnic minorities, have demonstrated lower utilization of preventive screening, including tests for early detection of breast and colorectal cancer.

    Authors: Rachel Wilf-Miron, Ronit Peled, Einat Yaari, Anna Vainer, Avi Porath and Ehud Kokia
    Citation: BMC Cancer 2011 11:376
    Content type: Research article Published on:

  44. Single drug use has not achieved satisfactory results in the treatment of prostate cancer, despite application of increasingly widespread targeted therapeutics. In the present study, the combined impact of the...

    Authors: Steffen Wedel, Lukasz Hudak, Jens-Michael Seibel, Jasmina Makarević, Eva Juengel, Igor Tsaur, Ana Waaga-Gasser, Axel Haferkamp and Roman A Blaheta
    Citation: BMC Cancer 2011 11:375
    Content type: Research article Published on:

  45. Making a definitive preoperative diagnosis of solitary pulmonary nodules (SPNs) found by CT has been a clinical challenge. We previously demonstrated that microRNAs (miRNAs) could be used as biomarkers for lun...

    Authors: Jun Shen, Ziling Liu, Nevins W Todd, Howard Zhang, Jipei Liao, Lei Yu, Maria A Guarnera, Ruiyun Li, Ling Cai, Min Zhan and Feng Jiang
    Citation: BMC Cancer 2011 11:374
    Content type: Research article Published on:

  47. Betulinic acid (BA) inhibits growth of several cancer cell lines and tumors and the effects of BA have been attributed to its mitochondriotoxicity and inhibition of multiple pro-oncogenic factors. Previous stu...

    Authors: Sudhakar Chintharlapalli, Sabitha Papineni, Ping Lei, Satya Pathi and Stephen Safe
    Citation: BMC Cancer 2011 11:371
    Content type: Research article Published on:

  48. Nasopharyngeal carcinoma (NPC) with lung metastasis alone has been reported as a relatively favorable prognostic group, and combined modality treatment might be indicated for selected cases. However, the progn...

    Authors: Xun Cao, Li-Ru He, Fang-Yun Xie, You-Fang Chen and Zhe-Sheng Wen
    Citation: BMC Cancer 2011 11:370
    Content type: Research article Published on:

  49. The National Comprehensive Cancer Network clinical practice guidelines in oncology-gastric cancer guidelines have been widely used to provide appropriate recommendations for the treatment of patients with gast...

    Authors: Xiaolong Zhang, Nanjing Li, Wen Wei, Wenxiu Yao, Ke Xie, Jiankun Hu, Lida Shen, Weizheng Ji, You Lu, Feng Wen, Yu Jiang, Feng Xu, Hong Feng, Feng Bi and Qiu Li
    Citation: BMC Cancer 2011 11:369
    Content type: Research article Published on:

  50. Late stage Ovarian Cancer is essentially incurable primarily due to late diagnosis and its inherent heterogeneity. Single agent treatments are inadequate and generally lead to severe side effects at therapeuti...

    Authors: Preetinder P Singh, Swapna Joshi, Pamela J Russell, Sham Nair and Aparajita Khatri
    Citation: BMC Cancer 2011 11:368
    Content type: Research article Published on:

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