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  1. The transcription factor SOX2, which is involved in the induction of pluripotent stem cells and contributes to colorectal carcinogenesis, is associated with a poor prognosis in colon cancer (CC). Furthermore, ...

    Authors: Jens Neumann, Fiorina Bahr, David Horst, Lydia Kriegl, Jutta Engel, Raquel Mejías-Luque, Markus Gerhard, Thomas Kirchner and Andreas Jung
    Citation: BMC Cancer 2011 11:518
    Content type: Research article Published on:

  2. The presence of bone metastases has excluded participation of prostate cancer patients in exercise intervention studies to date and is also a relative contraindication to supervised exercise in the community s...

    Authors: Daniel A Galvão, Dennis R Taaffe, Prue Cormie, Nigel Spry, Suzanne K Chambers, Carolyn Peddle-McIntyre, Michael Baker, James Denham, David Joseph, Geoff Groom and Robert U Newton
    Citation: BMC Cancer 2011 11:517
    Content type: Study protocol Published on:

  4. We previously found that administration of an interleukin 2/diphtheria toxin conjugate (DAB/IL2; Denileukin Diftitox; ONTAK) to stage IV melanoma patients depleted CD4+CD25HIFoxp3+ regulatory T cells and expanded...

    Authors: Sucheta Telang, Mary Ann Rasku, Amy L Clem, Karen Carter, Alden C Klarer, Wesley R Badger, Rebecca A Milam, Shesh N Rai, Jianmin Pan, Hana Gragg, Brian F Clem, Kelly M McMasters, Donald M Miller and Jason Chesney
    Citation: BMC Cancer 2011 11:515
    Content type: Research article Published on:

  6. Five-year survival for lung cancer has remained at 16% over last several decades largely due to the fact that over 50% of patients are diagnosed with locally-advanced or metastatic disease. Diagnosis at an ear...

    Authors: Elena Kupert, Marshall Anderson, Yin Liu, Paul Succop, Linda Levin, Jiang Wang, Kathryn Wikenheiser-brokamp, Pingping Chen, Susan M Pinney, Trudy Macdonald, Zhongyun Dong, Sandra Starnes and Shan Lu
    Citation: BMC Cancer 2011 11:513
    Content type: Research article Published on:

  7. The cytogenetic characteristic of Chronic Myeloid Leukemia (CML) is the formation of the Philadelphia chromosome gene product, BCR-ABL. Given that BCR-ABL is the specific target of Gleevec in CML treatment, we...

    Authors: Juin Hsien Chai, Yong Zhang, Wei Han Tan, Wee Joo Chng, Baojie Li and Xueying Wang
    Citation: BMC Cancer 2011 11:512
    Content type: Research article Published on:

  8. The availability of well-annotated prostate tissue samples through biobanks is key for research. Whereas fresh-frozen tissue is well suited for a broad spectrum of molecular analyses, its storage and handling ...

    Authors: Martin Braun, Roopika Menon, Pavel Nikolov, Robert Kirsten, Karen Petersen, David Schilling, Christina Schott, Sibylle Gündisch, Falko Fend, Karl-Friedrich Becker and Sven Perner
    Citation: BMC Cancer 2011 11:511
    Content type: Research article Published on:

  9. The role of chemotherapy in high-risk soft tissue sarcoma is controversial. Though many patients undergo initial curative resection, distant metastasis is a frequent event, resulting in 5-year overall survival...

    Authors: Thomas Schmitt, Burkhard Lehner, Bernd Kasper, Marc Bischof, Falk Roeder, Sascha Dietrich, Antonia Dimitrakopoulou-Strauss, Ludwig G Strauss, Gunhild Mechtersheimer, Patrick Wuchter, Anthony D Ho and Gerlinde Egerer
    Citation: BMC Cancer 2011 11:510
    Content type: Research article Published on:

  10. The activity of the epidermal growth factor receptor (EGFR)-directed monoclonal antibody cetuximab combined with oxaliplatin/leucovorin/5-fluorouracil (FUFOX) was assessed in first-line metastatic gastric and ...

    Authors: Birgit Luber, Joëlle Deplazes, Gisela Keller, Axel Walch, Sandra Rauser, Martin Eichmann, Rupert Langer, Heinz Höfler, Susanna Hegewisch-Becker, Gunnar Folprecht, Ewald Wöll, Thomas Decker, Esther Endlicher, Sylvie Lorenzen, Falko Fend, Christian Peschel…
    Citation: BMC Cancer 2011 11:509
    Content type: Research article Published on:

  11. A universal hallmark of cancer cells is the change in their glycosylation phenotype. One of the most frequent alterations in the normal glycosylation pattern observed during carcinogenesis is the enhancement o...

    Authors: Laura Muinelo-Romay, Susana Villar-Portela, Elisa Cuevas, Emilio Gil-Martín and Almudena Fernández-Briera
    Citation: BMC Cancer 2011 11:508
    Content type: Research article Published on:

  12. TMPRSS2-ERG gene fusions occur in about 50% of all prostate cancer cases and represent promising markers for molecular subtyping. Although TMPRSS2-ERG fusion seems to be a critical event in prostate cancer, the ...

    Authors: Jan C Brase, Marc Johannes, Heiko Mannsperger, Maria Fälth, Jennifer Metzger, Lukasz A Kacprzyk, Tatjana Andrasiuk, Stephan Gade, Michael Meister, Hüseyin Sirma, Guido Sauter, Ronald Simon, Thorsten Schlomm, Tim Beißbarth, Ulrike Korf, Ruprecht Kuner…
    Citation: BMC Cancer 2011 11:507
    Content type: Research article Published on:

  13. Signal transducer and activator of transcription 3 (STAT3) is an important transcription factor ubiquitously expressed in different cell types. STAT3 plays an essential role in cell survival, proliferation, an...

    Authors: Wen-Yong Wu, Jun Li, Zheng-Sheng Wu, Chang-Le Zhang and Xiang-Ling Meng
    Citation: BMC Cancer 2011 11:506
    Content type: Research article Published on:

  14. For patients with metastatic renal cell cancer (mRCC) who progressed on vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor therapy, the orally administered mammalian target of rapamyc...

    Authors: Charlotte M Huijts, Saskia J Santegoets, Alfons J van den Eertwegh, Laura S Pijpers, John B Haanen, Tanja D de Gruijl, Henk M Verheul and Hans J van der Vliet
    Citation: BMC Cancer 2011 11:505
    Content type: Study protocol Published on:

  15. The microenvironment within solid tumours can influence the metastatic dissemination of tumour cells, and recent evidence suggests that poorly oxygenated (hypoxic) cells in primary tumours can also affect the ...

    Authors: Kevin L Bennewith and Shoukat Dedhar
    Citation: BMC Cancer 2011 11:504
    Content type: Review Published on:

  16. Over the last decade, BMC Cancer has continuously published important research from the field of radiation oncology. Major developments in this field include the introduction of new imaging modalities into radiot...

    Authors: Dirk Vordermark
    Citation: BMC Cancer 2011 11:503
    Content type: Commentary Published on:

  18. Molecular classification has added important knowledge to breast cancer biology, but has yet to be implemented as a clinical standard. Full sequencing of breast cancer genomes could potentially refine classifi...

    Authors: Hans Kristian Moen Vollan and Carlos Caldas
    Citation: BMC Cancer 2011 11:501
    Content type: Review Published on:

  23. We analyzed the influence of 8 germinal polymorphisms of candidate genes potentially related to EGFR signalling (EGFR, EGF, CCND1) or antibody-directed cell cytotoxicity (FCGR2A and FCGR3A) on outcome of colorect...

    Authors: Laetitia Dahan, Emmanuelle Norguet, Marie-Christine Etienne-Grimaldi, Jean-Louis Formento, Mohamed Gasmi, Isabelle Nanni, Jean Gaudart, Stéphane Garcia, L'Houcine Ouafik, Jean-François Seitz and Gérard Milano
    Citation: BMC Cancer 2011 11:496
    Content type: Research article Published on:

  24. In Taiwan, there is a high incidence of breast cancer and a high prevalence of viral hepatitis. In this case-control study, we used a population-based insurance dataset to evaluate whether breast cancer in wom...

    Authors: Fu-Hsiung Su, Shih-Ni Chang, Pei-Chun Chen, Fung-Chang Sung, Chien-Tien Su and Chih-Ching Yeh
    Citation: BMC Cancer 2011 11:495
    Content type: Research article Published on:

  25. Laparoscopy-assisted surgery, fast-track perioperative treatment are both increasingly used in colorectal cancer treatment, for their short-time benefits of enhanced recovery and short hospital stays. However,...

    Authors: Jiao-Jiao Zhou, Jun Li, Xiao-Jiang Ying, Yong-Mao Song, Rong Chen, Gang Chen, Min Yan and Ke-Feng Ding
    Citation: BMC Cancer 2011 11:494
    Content type: Study protocol Published on:

  26. Cancer cachexia is a syndrome of progressive weight loss. Non-small cell lung cancer patients experience a high incidence of cachexia of 61%. Research into methods to combat cancer cachexia in various tumour s...

    Authors: Elaine S Rogers, Roderick D MacLeod, Joanna Stewart, Stephen P Bird and Justin WL Keogh
    Citation: BMC Cancer 2011 11:493
    Content type: Study protocol Published on:

  27. Little is known about the clinical features and prognostic factors of bone metastases of hepatocellular carcinoma (HCC) following liver transplantation (LT).

    Authors: Jian He, Zhao-Chong Zeng, Jia Fan, Jian Zhou, Jing Sun, Bing Chen, Ping Yang, Bin-Liang Wang, Bo-Heng Zhang and Jian-Ying Zhang
    Citation: BMC Cancer 2011 11:492
    Content type: Research article Published on:

  28. Statins have long been used as anti-hypercholesterolemia drugs, but numerous lines of evidence suggest that they may also bear anti-tumour potential. We have recently demonstrated that it was possible to isola...

    Authors: Julie Follet, Lionel Rémy, Vincent Hesry, Brigitte Simon, Danièle Gillet, Pierrick Auvray, Laurent Corcos and Catherine Le Jossic-Corcos
    Citation: BMC Cancer 2011 11:491
    Content type: Research article Published on:

  29. Cowden Syndrome (CS) patients with germ line point mutations in the PTEN gene are at high risk for developing breast cancer. It is believed that cells harboring these mutant PTEN alleles are predisposed to malign...

    Authors: Gobind Singh, Leticia Odriozola, Hong Guan, Colin R Kennedy and Andrew M Chan
    Citation: BMC Cancer 2011 11:490
    Content type: Research article Published on:

  30. There is increasing evidence that the presence of an ongoing systemic inflammatory response is associated with poor prognosis in patients with advanced cancers. We evaluated the relationships between clinical ...

    Authors: Jun-Eul Hwang, Ha-Na Kim, Dae-Eun Kim, Hyun-Jung Choi, Sung-Hoon Jung, Hyun-Jeong Shim, Woo-Kyun Bae, Eu-Chang Hwang, Sang-Hee Cho and Ik-Joo Chung
    Citation: BMC Cancer 2011 11:489
    Content type: Research article Published on:

  32. Paraneoplastic syndromes (PNSs) are common complications of lung cancer and often develop preceding the diagnosis of primary malignancy. Rheumatologic PNSs mimicking Adult-Onset Still' s Disease (AOSD) is a ra...

    Authors: Ning Wu, Qiang Li, Chang-Xin Gu, Toqeer Ahmed and Xiao-Peng Yao
    Citation: BMC Cancer 2011 11:487
    Content type: Case report Published on:

  33. The pathological complete response (pCR) after neoadjuvant chemotherapy is a surrogate marker for a favorable prognosis in breast cancer patients. Factors capable of predicting a pCR, such as the proliferation...

    Authors: Peter A Fasching, Katharina Heusinger, Lothar Haeberle, Melitta Niklos, Alexander Hein, Christian M Bayer, Claudia Rauh, Ruediger Schulz-Wendtland, Mayada R Bani, Michael Schrauder, Laura Kahmann, Michael P Lux, Johanna D Strehl, Arndt Hartmann, Arno Dimmler, Matthias W Beckmann…
    Citation: BMC Cancer 2011 11:486
    Content type: Research article Published on:

  34. Targeting the ubiquitin-proteasome pathway is a promising approach for anticancer strategies. Recently, we found Bik accumulation in cancer cell lines after they were treated with bortezomib. However, recent e...

    Authors: Wei Zhou, Jingzi Hu, Haimei Tang, Da Wang, Xuefeng Huang, Chao He and Hongbo Zhu
    Citation: BMC Cancer 2011 11:485
    Content type: Research article Published on:

  35. FGF receptor substrates (FRS2 and FRS3) are key adaptor proteins that mediate FGF-FGFR signalling in benign as well as malignant tissue. Here we investigated FRS2 and FRS3 as a means of disrupting global FGF s...

    Authors: Tania Valencia, Ajay Joseph, Naveen Kachroo, Steve Darby, Susan Meakin and Vincent J Gnanapragasam
    Citation: BMC Cancer 2011 11:484
    Content type: Research article Published on:

  36. Worldwide, cervical cancer is the second most common causes of cancer in women and represents an important mortality rate. Cisplatin (CIS) is a very important antitumoral agent and can lead tumor cells toward ...

    Authors: Georgina Hernandez-Flores, Pablo C Ortiz-Lazareno, Jose Manuel Lerma-Diaz, Jorge R Dominguez-Rodriguez, Luis F Jave-Suarez, Adriana del C Aguilar-Lemarroy, Ruth de Celis-Carrillo, Susana del Toro-Arreola, Yessica C Castellanos-Esparza and Alejandro Bravo-Cuellar
    Citation: BMC Cancer 2011 11:483
    Content type: Research article Published on:

  37. Osseous metastatic involvement of the spinal column affects many patients with a primary tumour disease of all entities. The consequences are pain both at rest and under exertion, impairments in going about da...

    Authors: Harald Rief, Alexandra D Jensen, Thomas Bruckner, Klaus Herfarth and Jürgen Debus
    Citation: BMC Cancer 2011 11:482
    Content type: Study protocol Published on:

  38. The prognosis of hepatocellular carcinoma (HCC) varies following surgical resection and the large variation remains largely unexplained. Studies have revealed the ability of clinicopathologic parameters and ge...

    Authors: Ke Hao, John Lamb, Chunsheng Zhang, Tao Xie, Kai Wang, Bin Zhang, Eugene Chudin, Nikki P Lee, Mao Mao, Hua Zhong, Danielle Greenawalt, Mark D Ferguson, Irene O Ng, Pak C Sham, Ronnie T Poon, Cliona Molony…
    Citation: BMC Cancer 2011 11:481
    Content type: Research article Published on:

  39. Targeted therapies are becoming an essential part of breast cancer treatment and agents targeting the type I insulin-like growth factor receptor (IGF-IR) are currently being investigated in clinical trials. On...

    Authors: Craig I Campbell and Roger A Moorehead
    Citation: BMC Cancer 2011 11:480
    Content type: Research article Published on:

  40. Psychosocial problems in cancer patients are often unrecognized and untreated due to the low awareness of the existence of these problems or pressures of time. The awareness of the need to identify psychosocia...

    Authors: Anna PBM Braeken, Gertrudis IJM Kempen, Daniëlle Eekers, Francis CJM van Gils, Ruud MA Houben and Lilian Lechner
    Citation: BMC Cancer 2011 11:479
    Content type: Research article Published on:

  41. In spite of increasing efforts to enhance patient safety, medication errors in hospitalised patients are still relatively common, but with potentially severe consequences. This study aimed to assess antineopla...

    Authors: Florence Ranchon, Gilles Salles, Hans-Martin Späth, Vérane Schwiertz, Nicolas Vantard, Stéphanie Parat, Florence Broussais, Benoît You, Sophie Tartas, Pierre Jean Souquet, Claude Dussart, Claire Falandry, Emilie Henin, Gilles Freyer and Catherine Rioufol
    Citation: BMC Cancer 2011 11:478
    Content type: Research article Published on:

  42. N-(4-hydroxyphenyl)retinamide (4-HPR, fenretinide) is a synthetic retinoid with potent pro-apoptotic activity against several types of cancer, but little is known regarding mechanisms leading to chemoresistance....

    Authors: Aintzane Apraiz, Jolanta K Idkowiak-Baldys, María Dolores Boyano, Gorka Pérez-Yarza, Yusuf A Hannun and Aintzane Asumendi
    Citation: BMC Cancer 2011 11:477
    Content type: Research article Published on:

  43. Gonadotrophin releasing hormone (GnRH) analogs lower estrogen levels in pre-menopausal breast cancer patients. GnRH receptor (GnRH-R) activation also directly inhibits the growth of certain cells. The applicab...

    Authors: Kevin Morgan, Colette Meyer, Nicola Miller, Andrew H Sims, Ilgin Cagnan, Dana Faratian, David J Harrison, Robert P Millar and Simon P Langdon
    Citation: BMC Cancer 2011 11:476
    Content type: Research article Published on:

  44. Concomitant chemo-radiotherapy (CCRT) has become an indispensable organ, but not always function preserving treatment modality for advanced head and neck cancer. To prevent/limit the functional side effects of...

    Authors: Valesca P Retèl, Lisette van der Molen, Frans JM Hilgers, Coen RN Rasch, Annemiek AAMHJ L'Ortye, Lotte MG Steuten and Wim H van Harten
    Citation: BMC Cancer 2011 11:475
    Content type: Research article Published on:

  45. The dynamic regulation of cell-cell adhesions is crucial for developmental processes, including tissue formation, differentiation and motility. Adherens junctions are important components of the junctional com...

    Authors: Teresa Rodríguez-Rigueiro, Manuel Valladares-Ayerbes, Mar Haz-Conde, Luis A Aparicio and Angélica Figueroa
    Citation: BMC Cancer 2011 11:474
    Content type: Research article Published on:

  46. Human papillomaviruses (HPV) are causally associated with ano-genital and a subset of head and neck cancers. Rising incidence of HPV+ anal cancers and head and neck cancers have now been demonstrated in the de...

    Authors: Robin Crawford, Anne-Laure Grignon, Sarah Kitson, David M Winder, Siolian LR Ball, Katie Vaughan, Margaret A Stanley, Jane C Sterling and Peter KC Goon
    Citation: BMC Cancer 2011 11:473
    Content type: Research article Published on:

  47. The polycomb transcription factor Yin Yang 1 (YY1) overexpression can be causally implicated in experimental tumor growth and metastasization. To date, there is no clinical evidence of YY1 involvement in outco...

    Authors: Filomena de Nigris, Licciana Zanella, Francesco Cacciatore, Anna De Chiara, Flavio Fazioli, Gennaro Chiappetta, Gaetano Apice, Teresa Infante, Mario Monaco, Raffaele Rossiello, Gaetano De Rosa, Marco Alberghini and Claudio Napoli
    Citation: BMC Cancer 2011 11:472
    Content type: Research article Published on:

  48. HER2/neu is an oncogene that facilitates neoplastic transformation due to its ability to transduce growth signals in a ligand-independent manner, is over-expressed in 20-30% of human breast cancers correlating w...

    Authors: Tobias Hahn, Deborah J Bradley-Dunlop, Laurence H Hurley, Daniel Von-Hoff, Stephen Gately, Disis L Mary, Hailing Lu, Manuel L Penichet, David G Besselsen, Brook B Cole, Tanisha Meeuwsen, Edwin Walker and Emmanuel T Akporiaye
    Citation: BMC Cancer 2011 11:471
    Content type: Research article Published on:

  49. Tumor Necrosis Factor-α Related Apoptosis Inducing Ligand (TRAIL) and agonistic antibodies to death receptor 4 and 5 are promising candidates for cancer therapy due to their ability to induce apoptosis selective...

    Authors: David J Taylor, Christine E Parsons, Haiyong Han, Arul Jayaraman and Kaushal Rege
    Citation: BMC Cancer 2011 11:470
    Content type: Research article Published on:

  50. Anaplastic thyroid carcinoma (ATC) is among the most aggressive human malignancies. It is associated with a high rate of local recurrence and with poor prognosis.

    Authors: Olfa Derbel, Sami Limem, Céline Ségura-Ferlay, Jean-Christophe Lifante, Christian Carrie, Jean-Louis Peix, Françoise Borson-Chazot, Claire Bournaud, Jean-Pierre Droz and Christelle de la Fouchardière
    Citation: BMC Cancer 2011 11:469
    Content type: Research article Published on:

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