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  1. Organic cation transporters (OCT) are responsible for the uptake and intracellular inactivation of a broad spectrum of endogenous substrates and detoxification of xenobiotics and chemotherapeutics. The transpo...

    Authors: Michael Heise, Anja Lautem, Johanna Knapstein, Jörn M Schattenberg, Maria Hoppe-Lotichius, Daniel Foltys, Nina Weiler, Anca Zimmermann, Arno Schad, Dirk Gründemann, Gerd Otto, Peter R Galle, Marcus Schuchmann and Tim Zimmermann
    Citation: BMC Cancer 2012 12:109
    Content type: Research article Published on:

  2. Gastrointestinal stromal tumors (GIST) mutational status is recognized factor related to the results of tyrosine kinase inhibitors therapy such as imatinib (IM) or sunitinib (SU). Arterial hypertension (AH) is...

    Authors: Piotr Rutkowski, Elżbieta Bylina, Anna Klimczak, Tomasz Świtaj, Sławomir Falkowski, Jacek Kroc, Iwona Ługowska, Magdalena Brzeskwiniewicz, Wojciech Melerowicz, Czesław Osuch, Ewa Mierzejewska, Kacper Wasielewski, Agnieszka Woźniak, Urszula Grzesiakowska, Zbigniew I Nowecki, Janusz A Siedlecki…
    Citation: BMC Cancer 2012 12:107
    Content type: Research article Published on:

  5. Despite aggressive multimodal treatments the overall survival of patients with high-risk neuroblastoma remains poor. The aim of this study was to identify novel combination chemotherapy to improve survival rat...

    Authors: Patricia S Tsang, Adam T Cheuk, Qing-Rong Chen, Young K Song, Thomas C Badgett, Jun S Wei and Javed Khan
    Citation: BMC Cancer 2012 12:101
    Content type: Research article Published on:

  6. First full term pregnancy (FFTP) completed at a young age has been linked to low long term breast cancer risk, whereas late FFTP pregnancy age confers high long term risk, compared to nulliparity. Our hypothes...

    Authors: Wenyi Qin, Ke Zhang, Beth Kliethermes, Rachel L Ruhlen, Eva P Browne, Kathleen F Arcaro and Edward R Sauter
    Citation: BMC Cancer 2012 12:100
    Content type: Research article Published on:

  7. The treatment of patients with malignant brain tumors remains a major oncological problem. The median survival of patients with glioblastoma multiforme (GBM), the most malignant type, is only 15 months after i...

    Authors: Karsten Geletneky, Johannes Huesing, Jean Rommelaere, Joerg R Schlehofer, Barbara Leuchs, Michael Dahm, Ottheinz Krebs, Magnus von Knebel Doeberitz, Bernard Huber and Jacek Hajda
    Citation: BMC Cancer 2012 12:99
    Content type: Study protocol Published on:

  8. The characteristics of cervical lymphatic metastasis in nasopharyngeal carcinoma (NPC) are not completely understood. As such, radiotherapy to the entire lymphatic of the neck bilaterally has been empirically ...

    Authors: Francis CH Ho, Ivan WK Tham, Arul Earnest, Khai Mun Lee and Jiade J Lu
    Citation: BMC Cancer 2012 12:98
    Content type: Research article Published on:

  9. Prenylated Rab acceptor 1 domain family member 3 (PRAF3) is involved in the regulation of many cellular processes including apoptosis, migration and invasion. This study was conducted to investigate the effect...

    Authors: Guo-Zhen Shi, Yang Yuan, Guo-Jun Jiang, Zhi-Jun Ge, Jian Zhou, De-Jun Gong, Jing Tao, Yong-Fei Tan and Sheng-Dong Huang
    Citation: BMC Cancer 2012 12:97
    Content type: Research article Published on:

  13. Osteosarcoma is a bone tumor that often affects children and young adults. Although a combination of surgery and chemotherapy has improved the survival rate in the past decades, local recurrence and metastases...

    Authors: Fritz Wimbauer, Caihong Yang, Kristen L Shogren, Minzhi Zhang, Ribu Goyal, Scott M Riester, Michael J Yaszemski and Avudaiappan Maran
    Citation: BMC Cancer 2012 12:93
    Content type: Research article Published on:

  14. The incidence of melanoma is considerably increasing worldwide. Frequent failing of classical treatments led to development of novel therapeutic strategies aiming at managing advanced forms of this skin cancer...

    Authors: Laurie Hamtiaux, Julien Masquelier, Giulio G Muccioli, Caroline Bouzin, Olivier Feron, Bernard Gallez and Didier M Lambert
    Citation: BMC Cancer 2012 12:92
    Content type: Research article Published on:

  15. The epithelial to mesenchymal transition (EMT) is a molecular process through which an epithelial cell undergoes transdifferentiation into a mesenchymal phenotype. The role of EMT in embryogenesis is well-char...

    Authors: Alexandria M Haslehurst, Madhuri Koti, Moyez Dharsee, Paulo Nuin, Ken Evans, Joseph Geraci, Timothy Childs, Jian Chen, Jieran Li, Johanne Weberpals, Scott Davey, Jeremy Squire, Paul C Park and Harriet Feilotter
    Citation: BMC Cancer 2012 12:91
    Content type: Research article Published on:

  16. Gastrointestinal stromal tumors (GIST), one of the most common mesenchymal tumors of the gastrointestinal tract, prior to routine immunohistochemical staining and the introduction of tyrosine kinase inhibitors...

    Authors: Jerry Call, Christopher D Walentas, Jens C Eickhoff and Norman Scherzer
    Citation: BMC Cancer 2012 12:90
    Content type: Research article Published on:

  17. Bevacizumab has an important role in first-line treatment of metastatic colorectal cancer. However, clinical trials studying its effect have involved distinct chemotherapy regimens with divergent results. The ...

    Authors: Ligia Traldi Macedo, Andre Bacellar da Costa Lima and Andre Deeke Sasse
    Citation: BMC Cancer 2012 12:89
    Content type: Research article Published on:

  18. Amphiregulin (AREG) and Epiregulin (EREG), ligands of EGFR, are reported to be predictive biomarkers of colorectal cancer patients treated with Cetuximab, an anti-EGFR antibody. The purpose of this study is to...

    Authors: Hidekazu Kuramochi, Go Nakajima, Yuka Kaneko, Ayako Nakamura, Yuji Inoue, Masakazu Yamamoto and Kazuhiko Hayashi
    Citation: BMC Cancer 2012 12:88
    Content type: Research article Published on:

  19. Pneumatosis intestinalis (PI), defined as the presence of gas in the bowel wall, and portal venous gas (PVG) are relatively rare radiological findings. Although several chemotherapeutic agents and anti-vascula...

    Authors: Joo Young Lee, Hye-Suk Han, Sung-Nam Lim, Young Kwang Shim, Yong Hyeok Choi, Ok-Jun Lee, Ki Hyeong Lee and Seung Taik Kim
    Citation: BMC Cancer 2012 12:87
    Content type: Case report Published on:

  20. The mammalian target of rapamycin (mTOR) is frequently activated in colon cancers due to mutations in the phosphatidylinositol 3-kinase (PI3K) pathway. Targeting mTOR with allosteric inhibitors of mTOR such as...

    Authors: Benjamin Blaser, Laurent Waselle, Anne Dormond-Meuwly, Marc Dufour, Didier Roulin, Nicolas Demartines and Olivier Dormond
    Citation: BMC Cancer 2012 12:86
    Content type: Research article Published on:

  21. Tumour surveillance via induction of TRAIL-mediated apoptosis is a key mechanism, how the immune system prevents malignancy. To determine if gene variants in the TRAIL receptor I (DR4) gene affect the risk of hep...

    Authors: Christian Körner, Katarina Riesner, Benjamin Krämer, Marianne Eisenhardt, Andreas Glässner, Franziska Wolter, Thomas Berg, Tobias Müller, Tilman Sauerbruch, Jacob Nattermann, Ulrich Spengler and Hans Dieter Nischalke
    Citation: BMC Cancer 2012 12:85
    Content type: Research article Published on:

  22. Genes that, when mutated, cause Fanconi anemia or greatly increase breast cancer risk encode for proteins that converge on a homology-directed DNA damage repair process. Mutations in the SLX4 gene, which encodes ...

    Authors: Juana Fernández-Rodríguez, Francisco Quiles, Ignacio Blanco, Alex Teulé, Lídia Feliubadaló, Jesús del Valle, Mónica Salinas, Àngel Izquierdo, Esther Darder, Detlev Schindler, Gabriel Capellá, Joan Brunet, Conxi Lázaro and Miguel Angel Pujana
    Citation: BMC Cancer 2012 12:84
    Content type: Research article Published on:

  23. MicroRNA-126 is the only microRNA (miRNA) known to be endothelial cell-specific influencing angiogenesis in several ways. The aim of the present study was to analyse the possible predictive value of miRNA-126 ...

    Authors: Torben Frøstrup Hansen, Flemming Brandt Sørensen, Jan Lindebjerg and Anders Jakobsen
    Citation: BMC Cancer 2012 12:83
    Content type: Research article Published on:

  24. The membrane cytoskeletal crosslinker, ezrin, a member of the ERM family of proteins, is frequently over-expressed in human breast cancers, and is required for motility and invasion of epithelial cells. Our gr...

    Authors: Hannah Mak, Alexandra Naba, Sonal Varma, Colleen Schick, Andrew Day, Sandip K SenGupta, Monique Arpin and Bruce E Elliott
    Citation: BMC Cancer 2012 12:82
    Content type: Research article Published on:

  25. KAI1 was initially identified as a metastasis-suppressor gene in prostate cancer. It is a member of the tetraspan transmembrane superfamily (TM4SF) of membrane glycoproteins. As part of a tetraspanin-enriched ...

    Authors: Jung-Jin Park, Yeung Bae Jin, Yoon-Jin Lee, Jae-Seon Lee, Yun-Sil Lee, Young-Gyu Ko and Minyoung Lee
    Citation: BMC Cancer 2012 12:81
    Content type: Research article Published on:

  26. Medulloblastoma is the most common malignant brain tumor in children and remains a therapeutic challenge due to its significant therapy-related morbidity. Polo-like kinase 1 (PLK1) is highly expressed in many can...

    Authors: Peter S Harris, Sujatha Venkataraman, Irina Alimova, Diane K Birks, Andrew M Donson, Jeffrey Knipstein, Adrian Dubuc, Michael D Taylor, Michael H Handler, Nicholas K Foreman and Rajeev Vibhakar
    Citation: BMC Cancer 2012 12:80
    Content type: Research article Published on:

  27. The dyslexia candidate gene, DYX1C1, shown to regulate and interact with estrogen receptors and involved in the regulation of neuronal migration, has recently been proposed as a putative cancer biomarker. This st...

    Authors: Gustaf Rosin, Ulf Hannelius, Linda Lindström, Per Hall, Jonas Bergh, Johan Hartman and Juha Kere
    Citation: BMC Cancer 2012 12:79
    Content type: Research article Published on:

  28. The number of circulating tumor cells (CTCs) in metastatic prostate cancer patients provides prognostic and predictive information. However, it is the molecular characterization of CTCs that offers insight int...

    Authors: Mark Jesus M Magbanua, Eduardo V Sosa, Janet H Scott, Jeff Simko, Colin Collins, Dan Pinkel, Charles J Ryan and John W Park
    Citation: BMC Cancer 2012 12:78
    Content type: Technical advance Published on:

  29. Diagnosis and treatment of ovarian cancer (OC) entail severe symptom burden and a significant loss of quality of life (QOL). Somatic and psychological impairments may persist well beyond active therapy. Althou...

    Authors: Verena Meraner, Eva-Maria Gamper, Anna Grahmann, Johannes M Giesinger, Petra Wiesbauer, Monika Sztankay, Alain G Zeimet, Barbara Sperner-Unterweger and Bernhard Holzner
    Citation: BMC Cancer 2012 12:77
    Content type: Research article Published on:

  30. A disintegrin and metalloproteinase (ADAMs) have been associated with multiple malignancies. ADAMs are involved in cell fusion, cell migration, membrane protein shedding and proteolysis. ADAM8 has been found t...

    Authors: Valerie Zielinski, Markus Brunner, Gregor Heiduschka, Sven Schneider, Rudolf Seemann, Boban Erovic and Dietmar Thurnher
    Citation: BMC Cancer 2012 12:76
    Content type: Research article Published on:

  31. Recent studies suggest a role of the proteasome activator, REGγ, in cancer progression. Since there are limited numbers of known REGγ targets, it is not known which cancers and pathways are associated with REGγ.

    Authors: Jing He, Long Cui, Yu Zeng, Guangqiang Wang, Ping Zhou, Yuanyuan Yang, Lei Ji, Yanyan Zhao, Jiwu Chen, Zhuo Wang, Tieliu Shi, Pei Zhang, Rui Chen and Xiaotao Li
    Citation: BMC Cancer 2012 12:75
    Content type: Research article Published on:

  32. The biological relevance of nuclear ErbB-2/HER2 (NuclErbB-2) presence in breast tumors remains unexplored. In this study we assessed the clinical significance of ErbB-2 nuclear localization in primary invasive...

    Authors: Roxana Schillaci, Pablo Guzmán, Florencia Cayrol, Wendy Beguelin, María C Díaz Flaqué, Cecilia J Proietti, Viviana Pineda, Jorge Palazzi, Isabel Frahm, Eduardo H Charreau, Esteban Maronna, Juan C Roa and Patricia V Elizalde
    Citation: BMC Cancer 2012 12:74
    Content type: Research article Published on:

  33. Breast cancer metastasis suppressor 1 (BRMS1) blocks metastasis in melanoma xenografts; however, its usefulness as a biomarker in human melanomas has not been widely studied. The goal was to measure BRMS1 expr...

    Authors: Ana Slipicevic, Ruth Holm, Elisabeth Emilsen, Anne Katrine Ree Rosnes, Danny R Welch, Gunhild M Mælandsmo and Vivi Ann Flørenes
    Citation: BMC Cancer 2012 12:73
    Content type: Research article Published on:

  34. Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent and lethal cancers worldwide and mortality mostly results from loco-regional recurrence and metastasis. Despite its significance, our ...

    Authors: Gustavo A Acuña Sanhueza, Leonie Faller, Babitha George, Jennifer Koffler, Vinko Misetic, Christa Flechtenmacher, Gerhard Dyckhoff, Peter P Plinkert, Peter Angel, Christian Simon and Jochen Hess
    Citation: BMC Cancer 2012 12:72
    Content type: Research article Published on:

  35. X-ray repair cross-complementing group 1 (XRCC1) protein plays an important role in the repair of DNA damage and adducts. Single nucleotide polymorphisms (SNPs) of XRCC1 are suspected to have some relationship wi...

    Authors: Zhigang Cui, Zhihua Yin, Xuelian Li, Wei Wu, Peng Guan and Baosen Zhou
    Citation: BMC Cancer 2012 12:71
    Content type: Research article Published on:

  36. Our aim was to compare survival of the various treatment modality groups of chemotherapy and/or radiotherapy in relation to SEMS (self-expanding metal stents) in a retrospective case-control study. We have mad...

    Authors: George Sgourakis, Ines Gockel, Constantine Karaliotas, Markus Moehler, Carl Christoph Schimanski, Heinz Schmidberger and Theodor Junginger
    Citation: BMC Cancer 2012 12:70
    Content type: Research article Published on:

  37. Most human cancers show inactivation of both pRB- and p53-pathways. While retinoblastomas are initiated by loss of the RB1 tumor suppressor gene, TP53 mutations have not been found. High expression of the p53-ant...

    Authors: Kwong-Him To, Sanja Pajovic, Brenda L Gallie and Brigitte L Thériault
    Citation: BMC Cancer 2012 12:69
    Content type: Research article Published on:

  38. Intensity-modulated radiation therapy (IMRT) provides excellent locoregional control for nasopharyngeal carcinoma (NPC), and has gradually replaced two-dimensional conventional radiotherapy as the first-line r...

    Authors: Ying Sun, Ling-Long Tang, Lei Chen, Wen-Fei Li, Yan-Ping Mao, Li-Zhi Liu, Ai-Hua Lin, Li Li and Jun Ma
    Citation: BMC Cancer 2012 12:68
    Content type: Research article Published on:

  39. Methylation of CpG sites in genomic DNA plays an important role in gene regulation and especially in gene silencing. We have reported mechanisms of epigenetic regulation for expression of mucins, which are mar...

    Authors: Seiya Yokoyama, Sho Kitamoto, Norishige Yamada, Izumi Houjou, Tamotsu Sugai, Shin-ichi Nakamura, Yoshifumi Arisaka, Kyoichi Takaori, Michiyo Higashi and Suguru Yonezawa
    Citation: BMC Cancer 2012 12:67
    Content type: Research article Published on:

  40. The Keap1-Nrf2 pathway has been reported to be impaired in several cancers. However, the status of Keap1-Nrf2 system in human colorectal cancer (CRC) has not been elucidated.

    Authors: Naoyuki Hanada, Takenori Takahata, Qiliang Zhou, Xulu Ye, Ruowen Sun, Jugoh Itoh, Atsushi Ishiguro, Hiroshi Kijima, Junsei Mimura, Ken Itoh, Shinsaku Fukuda and Yasuo Saijo
    Citation: BMC Cancer 2012 12:66
    Content type: Research article Published on:

  41. The clinical significance between particularly interesting new cysteine-histidine rich protein (PINCH) expression and radiotherapy (RT) in tumours is not known. In this study, the expression of PINCH and its r...

    Authors: Annica Holmqvist, Jingfang Gao, Birgitta Holmlund, Gunnar Adell, John Carstensen, Dianne Langford and Xiao-Feng Sun
    Citation: BMC Cancer 2012 12:65
    Content type: Research article Published on:

  42. Lynch syndrome (LS) is the most common form of inherited predisposition to colorectal cancer (CRC), accounting for 2-5% of all CRC. LS is an autosomal dominant disease characterized by mutations in the mismatc...

    Authors: Erika Maria Monteiro Santos, Mev Dominguez Valentin, Felipe Carneiro, Ligia Petrolini de Oliveira, Fabio de Oliveira Ferreira, Samuel Aguiar Junior, Wilson Toshihiko Nakagawa, Israel Gomy, Victor Evangelista de Faria Ferraz, Wilson Araujo da Silva Junior, Dirce Maria Carraro and Benedito Mauro Rossi
    Citation: BMC Cancer 2012 12:64
    Content type: Research article Published on:

  43. BCA2 is an E3 ligase linked with hormone responsive breast cancers. We have demonstrated previously that the RING E3 ligase BCA2 has autoubiquitination activity and is a very unstable protein. Previously, only...

    Authors: Stephanie Bacopulos, Yutaka Amemiya, Wenyi Yang, Judit Zubovits, Angelika Burger, Martin Yaffe and Arun K Seth
    Citation: BMC Cancer 2012 12:63
    Content type: Research article Published on:

  44. Colorectal cancer (CRC) is among the leading causes of cancer-related morbidity and mortality worldwide. Despite clinical practice guidelines to guide surveillance care for those who have completed treatment f...

    Authors: Mariko Carey, Rob Sanson-Fisher, Finlay Macrae, David Hill, Catherine D'Este, Christine Paul and Christopher Doran
    Citation: BMC Cancer 2012 12:62
    Content type: Study protocol Published on:

  45. Development of accurate therapeutic approaches to salivary gland neoplasms depends on better understanding of their molecular pathogenesis. Tumour growth is regulated by the balance between proliferation and a...

    Authors: Carolina Cavaliéri Gomes, Vanessa Fátima Bernardes, Marina Gonçalves Diniz, Luiz De Marco and Ricardo Santiago Gomez
    Citation: BMC Cancer 2012 12:61
    Content type: Research article Published on:

  46. WNT7a, a member of the Wnt ligand family implicated in several developmental processes, has also been reported to be dysregulated in some types of tumors; however, its function and implication in oncogenesis i...

    Authors: Alejandra B Ochoa-Hernández, Moisés Ramos-Solano, Ivan D Meza-Canales, Beatriz García-Castro, Mónica A Rosales-Reynoso, Judith A Rosales-Aviña, Esperanza Barrera-Chairez, Pablo C Ortíz-Lazareno, Georgina Hernández-Flores, Alejandro Bravo-Cuellar, Luis F Jave-Suarez, Patricio Barros-Núñez and Adriana Aguilar-Lemarroy
    Citation: BMC Cancer 2012 12:60
    Content type: Research article Published on:

  48. Colorectal cancer is the third most common cancer and the third leading cause of cancer-related death. Bevacizumab is a humanized monoclonal antibody developed against vascular endothelial growth factor (VEGF)...

    Authors: Atil Bisgin, Aysegul Kargi, Arzu D Yalcin, Cigdem Aydin, Deniz Ekinci, Burhan Savas and Salih Sanlioglu
    Citation: BMC Cancer 2012 12:58
    Content type: Research article Published on:

  49. Toll-like receptors (TLR) are key innate immunity receptors participating in an immune response. Growing evidence suggests that mutations of TLR2/TLR9 gene are associated with the progress of cancers. The pres...

    Authors: Xie Junjie, Jiang Songyao, Shi Minmin, Song Yanyan, Shen Baiyong, Deng Xiaxing, Jin Jiabin, Zhan Xi and Chen Hao
    Citation: BMC Cancer 2012 12:57
    Content type: Research article Published on:

  50. Although fibroblast growth factor 19 (FGF19) can promote liver carcinogenesis in mice, its involvement in human hepatocellular carcinoma (HCC) has not been well investigated. FGF19, a member of the FGF family,...

    Authors: Seiki Miura, Noboru Mitsuhashi, Hiroaki Shimizu, Fumio Kimura, Hiroyuki Yoshidome, Masayuki Otsuka, Atsushi Kato, Takashi Shida, Daiki Okamura and Masaru Miyazaki
    Citation: BMC Cancer 2012 12:56
    Content type: Research article Published on:

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