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  1. The APC tumor suppressor is mutated or downregulated in many tumor types, and is prominently localized to punctate clusters at protrusion tips in migratory cells, such as in astrocytes where it has been implic...

    Authors: Matthew A Odenwald, Jenifer R Prosperi and Kathleen H Goss
    Citation: BMC Cancer 2013 13:12
    Content type: Research article Published on:

  2. Myelosuppressive chemotherapy can lead to dose-limiting febrile neutropenia. Prophylactic use of recombinant human G-CSF such as daily filgrastim and once-per-cycle pegfilgrastim may reduce the incidence of fe...

    Authors: Arash Naeim, Henry J Henk, Laura Becker, Victoria Chia, Sejal Badre, Xiaoyan Li and Robert Deeter
    Citation: BMC Cancer 2013 13:11
    Content type: Research article Published on:

  3. HPV is related to a number of cancer types, causing a considerable burden in both genders in Europe. Female vaccination programs can substantially reduce the incidence of HPV-related diseases in women and, to ...

    Authors: Rémi Marty, Stéphane Roze, Xavier Bresse, Nathalie Largeron and Jayne Smith-Palmer
    Citation: BMC Cancer 2013 13:10
    Content type: Research article Published on:

  4. Faced with a life-threatening illness, such as cancer, many patients develop stress symptoms, i.e. avoidance behaviour, intrusive thoughts and worry. Stress management interventions have proven to be effective...

    Authors: Cecilia Arving, Inger Thormodsen, Guri Brekke, Olav Mella, Sveinung Berntsen and Karin Nordin
    Citation: BMC Cancer 2013 13:9
    Content type: Study protocol Published on:

  5. A subset of lung adenocarcinomas harboring an EML4-ALK fusion gene resulting in dominant oncogenic activity has emerged as a target for specific therapy. EML4-ALK fusion confers a characteristic histology and is ...

    Authors: Hironori Ninomiya, Motohiro Kato, Masashi Sanada, Kengo Takeuchi, Kentaro Inamura, Noriko Motoi, Hiroko Nagano, Kimie Nomura, Yukinori Sakao, Sakae Okumura, Hiroyuki Mano, Seishi Ogawa and Yuichi Ishikawa
    Citation: BMC Cancer 2013 13:8
    Content type: Research article Published on:

  6. Diabetic patients have a higher risk of bladder cancer and benign prostatic hyperplasia (BPH). Theoretically, BPH patients may have an increased risk of bladder cancer because residual urine in the bladder sur...

    Authors: Chin-Hsiao Tseng
    Citation: BMC Cancer 2013 13:7
    Content type: Research article Published on:

  7. Mortality rates for cancer are decreasing in patients under 60 and increasing in those over 60 years of age. The reasons for these differences in mortality rates remain poorly understood. One explanation may b...

    Authors: Janine K Cataldo, Steven Paul, Bruce Cooper, Helen Skerman, Kimberly Alexander, Bradley Aouizerat, Virginia Blackman, John Merriman, Laura Dunn, Christine Ritchie, Patsy Yates and Christine Miaskowski
    Citation: BMC Cancer 2013 13:6
    Content type: Research article Published on:

  8. Alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) have been used as diagnostic tools for hepatocellular carcinoma (HCC). However, prediction of outcome using AFP and DCP has not been elucidated. ...

    Authors: Yong Kang Lee, Seung Up Kim, Do Young Kim, Sang Hoon Ahn, Kwang Hun Lee, Do Yun Lee, Kwang-Hyub Han, Chae Yoon Chon and Jun Yong Park
    Citation: BMC Cancer 2013 13:5
    Content type: Research article Published on:

  9. Cancer is a significant and growing problem worldwide. While this increase may, in part, be attributed to increasing longevity, improved case notifications and risk-enhancing lifestyle (such as smoking, diet a...

    Authors: Luca Cegolon, Cristiano Salata, Elisabete Weiderpass, Paolo Vineis, Giorgio Palù and Giuseppe Mastrangelo
    Citation: BMC Cancer 2013 13:4
    Content type: Debate Published on:

  10. Sunitinib interacts with radiation therapy, leading to synergism of the toxicities of these treatments. Radiation recall pneumonitis is a rare but serious complication of targeted therapy with tyrosine kinase ...

    Authors: Takeshi Yuasa, Shinichi Kitsukawa, Gen Sukegawa, Shinya Yamamoto, Keita Kudo, Kazunari Miyazawa, Takuyo Kozuka, Sohei Harada and Junji Yonese
    Citation: BMC Cancer 2013 13:3
    Content type: Case report Published on:

  12. Breast cancer is a potentially fatal malignancy in females despite the improvement in therapeutic techniques. The identification of novel molecular signatures is needed for earlier detection, monitoring effect...

    Authors: Emman Shubbar, Anikó Kovács, Shahin Hajizadeh, Toshima Z Parris, Szilárd Nemes, Katrin Gunnarsdóttir, Zakaria Einbeigi, Per Karlsson and Khalil Helou
    Citation: BMC Cancer 2013 13:1
    Content type: Research article Published on:

  13. There is a critical need for improved diagnostic markers for high grade serous epithelial ovarian cancer (SEOC). MicroRNAs are stable in the circulation and may have utility as biomarkers of malignancy. We inv...

    Authors: Casina WS Kan, Michael A Hahn, Gregory B Gard, Jayne Maidens, Jung Yoon Huh, Deborah J Marsh and Viive M Howell
    Citation: BMC Cancer 2012 12:627
    Content type: Research article Published on:

  14. This study reports the reliability and validity of a questionnaire designed to measure the time from detection of a breast cancer to arrival at a cancer hospital, as well as the factors that are associated wit...

    Authors: Karla Unger-Saldaña, Ingris Peláez-Ballestas and Claudia Infante-Castañeda
    Citation: BMC Cancer 2012 12:626
    Content type: Research article Published on:

  15. The purpose of the present study was to evaluate the prognostic value of POSTN expression following prostatectomy.

    Authors: Pier Vitale Nuzzo, Alessandra Rubagotti, Linda Zinoli, Francesco Ricci, Sandra Salvi, Simona Boccardo and Francesco Boccardo
    Citation: BMC Cancer 2012 12:625
    Content type: Research article Published on:

  16. G-protein-coupled estrogen receptor (GPER/GPR30) was reported to bind 17β-estradiol (E2), tamoxifen, and ICI 182,780 (fulvestrant) and promotes activation of epidermal growth factor receptor (EGFR)-mediated signa...

    Authors: Venkatakrishna Rao Jala, Brandie N Radde, Bodduluri Haribabu and Carolyn M Klinge
    Citation: BMC Cancer 2012 12:624
    Content type: Research article Published on:

  17. High-grade gliomas including glioblastoma multiforme (GBM) are among the most malignant and aggressive of tumors, and have a very poor prognosis despite a temozolomide-based intensive treatment. Therefore, a n...

    Authors: Yasuto Akiyama, Chie Oshita, Akiko Kume, Akira Iizuka, Haruo Miyata, Masaru Komiyama, Tadashi Ashizawa, Mika Yagoto, Yoshiaki Abe, Koichi Mitsuya, Reiko Watanabe, Takashi Sugino, Ken Yamaguchi and Yoko Nakasu
    Citation: BMC Cancer 2012 12:623
    Content type: Research article Published on:

  18. The ubiquitin-proteasome system and macroautophagy (hereafter referred to autophagy) are two complementary pathways for protein degradation. Emerging evidence suggests that proteasome inhibition might be a pro...

    Authors: Chuan Liu, Xu Yan, Hua-Qin Wang, Yan-Yan Gao, Juanjuan Liu, Zhenhua Hu, Dawo Liu, Jian Gao and Bei Lin
    Citation: BMC Cancer 2012 12:622
    Content type: Research article Published on:

  19. The minor allele of SNP rs3803662 has been shown to correlate with increased breast cancer risk and with lower expression of TOX3. The SNP is closely located to TOX3 residing within an uncharacterised gene LOC643...

    Authors: Eydis Th Gudmundsdottir, Rosa B Barkardottir, Adalgeir Arason, Haukur Gunnarsson, Laufey Th Amundadottir, Bjarni A Agnarsson, Oskar Th Johannsson and Inga Reynisdottir
    Citation: BMC Cancer 2012 12:621
    Content type: Research article Published on:

  20. The abundance of circulating endothelial cells (CECs) and circulating endothelial progenitor cells (CEPs), which serve as surrogate markers for angiogenesis, may be affected by chemotherapy. We studied their d...

    Authors: Yu-Hsuan Kuo, Ching-Hung Lin, Wen-Yi Shau, Te-Jung Chen, Shih-Hung Yang, Shu-Min Huang, Chun Hsu, Yen-Shen Lu and Ann-Lii Cheng
    Citation: BMC Cancer 2012 12:620
    Content type: Research article Published on:

  21. Survivin, a member of the family of inhibitor of apoptosis proteins, functions as a key regulator of mitosis and programmed cell death. YM155, a novel molecular targeted agent, suppresses survivin, which is ov...

    Authors: Yan-Fang Tao, Jun Lu, Xiao-Juan Du, Li-Chao Sun, Xuan Zhao, Liang Peng, Lan Cao, Pei-Fang Xiao, Li Pang, Dong Wu, Na Wang, Xing Feng, Yan-Hong Li, Jian Ni, Jian Wang and Jian Pan
    Citation: BMC Cancer 2012 12:619
    Content type: Research article Published on:

  22. The causal association between persistent human papillomavirus (HPV) infection and cervical cancer has been established, but the mechanisms that favor HPV persistence in cervical cells are still unknown. The d...

    Authors: Anna Gillio-Tos, Maria da Graça Bicalho, Valentina Fiano, Chiara Grasso, Valentina Tarallo, Laura De Marco, Morena Trevisan, MarinaBarbaradeSousa Xavier, Renata Slowik, Newton S Carvalho, Carlos A Maestri, Hadriano M Lacerda, Daniela Zugna, Lorenzo Richiardi and Franco Merletti
    Citation: BMC Cancer 2012 12:618
    Content type: Research article Published on:

  23. The oxidative stress mechanism is of particular interest in the pathogenesis of glioma, given the high rate of oxygen metabolism in the brain. Potential links between polymorphisms of antioxidant genes and gli...

    Authors: Peng Zhao, Lin Zhao, Peng Zou, Ailin Lu, Ning Liu, Wei Yan, Chunsheng Kang, Zhen Fu, Yongping You and Tao Jiang
    Citation: BMC Cancer 2012 12:617
    Content type: Research article Published on:

  24. Presence of disseminated tumor cells (DTCs) in bone marrow (BM) after completion of systemic adjuvant treatment predicts reduced survival in breast cancer. The present study explores the use of DTCs to identif...

    Authors: Marit Synnestvedt, Elin Borgen, Erik Wist, Gro Wiedswang, Kjetil Weyde, Terje Risberg, Christian Kersten, Ingvil Mjaaland, Lise Vindi, Cecilie Schirmer, Jahn Martin Nesland and Bjørn Naume
    Citation: BMC Cancer 2012 12:616
    Content type: Research article Published on:

  25. Asbestos is the main cause of MPM in industrialized countries. Even since asbestos is banned in most developed countries, the peak wave of MPM incidence is anticipated for the next years due to the long latenc...

    Authors: Ulf Petrausch, Petra C Schuberth, Christian Hagedorn, Alex Soltermann, Sandra Tomaszek, Rolf Stahel, Walter Weder and Christoph Renner
    Citation: BMC Cancer 2012 12:615
    Content type: Study protocol Published on:

  26. Diagnosis of multiple endocrine neoplasia type 1 (MEN1) is commonly based on clinical criteria, and confirmed by genetic testing. In patients without known MEN1-related germline mutations, the possibility of a...

    Authors: Enrico Erdas, Nicola Aste, Luca Pilloni, Angelo Nicolosi, Sergio Licheri, Antonello Cappai, Marco Mastinu, Filomena Cetani, Elena Pardi, Stefano Mariotti and Mariano Pomata
    Citation: BMC Cancer 2012 12:614
    Content type: Case report Published on:

  27. In breast cancer, diabetes diagnosed prior to cancer (previously diagnosed) is associated with advanced cancer stage and increased mortality. However, in the general population, 40% of diabetes is undiagnosed ...

    Authors: Robert I Griffiths, Mark D Danese, Michelle L Gleeson and José M Valderas
    Citation: BMC Cancer 2012 12:613
    Content type: Research article Published on:

  29. HuR is an RNA-binding protein that post-transcriptionally modulates the expressions of various target genes implicated in carcinogenesis, such as CCNA2 encoding cyclin A. No prior study attempted to evaluate the ...

    Authors: Peir-In Liang, Wei-Ming Li, Yu-Hui Wang, Ting-Feng Wu, Wen-Ren Wu, Alex C Liao, Kun-Hung Shen, Yu-Ching Wei, Chung-Hsi Hsing, Yow-Ling Shiue, Hsuan-Ying Huang, Han-Ping Hsu, Li-Tzon Chen, Ching-Yih Lin, Chein Tai, Chun-Mao Lin…
    Citation: BMC Cancer 2012 12:611
    Content type: Research article Published on:

  30. The goal of this study was to identify the clinicopathological factors of co-existing papillary thyroid cancer (PTC) in patients with Hashimoto’s thyroiditis (HT) and provide information to aid in the diagnosi...

    Authors: Ling Zhang, Hui Li, Qing-hai Ji, Yong-xue Zhu, Zhuo-ying Wang, Yu Wang, Cai-ping Huang, Qiang Shen, Duan-shu Li and Yi Wu
    Citation: BMC Cancer 2012 12:610
    Content type: Research article Published on:

  31. There is no consensus on the indication for salvage chemoradiotherapy (CRT) after failure of primary chemotherapy for locally advanced pancreatic cancer (LAPC). Here we report on the retrospective analysis of ...

    Authors: Hiroshi Mayahara, Yoshinori Ito, Chigusa Morizane, Hideki Ueno, Takuji Okusaka, Shunsuke Kondo, Naoya Murakami, Madoka Morota, Minako Sumi and Jun Itami
    Citation: BMC Cancer 2012 12:609
    Content type: Research article Published on:

  32. The malignant transformation of precancerous colorectal lesions involves progressive alterations at both the molecular and morphologic levels, the latter consisting of increases in size and in the degree of ce...

    Authors: Rosalia Maglietta, Vania Cosma Liuzzi, Elisa Cattaneo, Endre Laczko, Ada Piepoli, Anna Panza, Massimo Carella, Orazio Palumbo, Teresa Staiano, Federico Buffoli, Angelo Andriulli, Giancarlo Marra and Nicola Ancona
    Citation: BMC Cancer 2012 12:608
    Content type: Research article Published on:

  33. Malignant glioma is a common primary tumor of the central nervous system. Brevican, an abundant extracellular matrix component in the adult brain, plays a critical role in the process of glioma. The mechanisms...

    Authors: Renquan Lu, Chengsheng Wu, Lin Guo, Yingchao Liu, Wei Mo, Huijie Wang, Jianbo Ding, Eric T Wong and Min Yu
    Citation: BMC Cancer 2012 12:607
    Content type: Research article Published on:

  34. An n-6 essential fatty acid, arachidonic acid (ARA) is converted into prostaglandin E2, which is involved in tumour extension. However, it is unclear whether dietary ARA intake leads to cancer in humans. We thus ...

    Authors: Mai Sakai, Saki Kakutani, Chika Horikawa, Hisanori Tokuda, Hiroshi Kawashima, Hiroshi Shibata, Hitomi Okubo and Satoshi Sasaki
    Citation: BMC Cancer 2012 12:606
    Content type: Research article Published on:

  35. Neoplastic transformation of cultured cells by a number of oncogenes such as src suppresses gap junctional, intercellular communication (GJIC); however, the role of Src and its effector Signal transducer and acti...

    Authors: Mulu Geletu, Rozanne Arulanandam, Samantha Greer, Aaron Trotman-Grant, Evangelia Tomai and Leda Raptis
    Citation: BMC Cancer 2012 12:605
    Content type: Research article Published on:

  36. The aim of this study was to measure the biological characteristics involved in tumorigenesis and the progression of breast cancer in symptomatic and screen-detected carcinomas to identify possible differences.

    Authors: Maximino Redondo, Rafael Funez, Francisco Medina-Cano, Isabel Rodrigo, Mercedes Acebal, Teresa Tellez, M Jose Roldan, M Luisa Hortas, Ana Bellinvia, Teresa Pereda, Laia Domingo, María Morales-Suarez Varela, Maria Sala and Antonio Rueda
    Citation: BMC Cancer 2012 12:604
    Content type: Research article Published on:

  37. Chemotherapy induced nausea and vomiting (CINV) remains a major problem that seriously impairs the quality of life (QoL) in cancer patients receiving chemotherapy regimens. Complementary medicines, including h...

    Authors: David Pérol, Jocelyne Provençal, Anne-claire Hardy-Bessard, David Coeffic, Jean-Phillipe Jacquin, Cécile Agostini, Thomas Bachelot, Jean-Paul Guastalla, Xavier Pivot, Jean-Pierre Martin, Agathe Bajard and Isabelle Ray-Coquard
    Citation: BMC Cancer 2012 12:603
    Content type: Research article Published on:

  38. Esophageal squamous cell carcinoma (ESCC) shows geographic variations in incidence, with high incidences (>50/105 person-years) in central Asia, including North Eastern Iran (Golestan) and Northern India (Kashmir...

    Authors: Behnoush Abedi-Ardekani, Nazir Ahmad Dar, Mohammad Muzaffar Mir, Showkat Ahmad Zargar, M Muqbool Lone, Ghyslaine Martel-Planche, Stéphanie Villar, Mounia Mounawar, Farrokh Saidi, Reza Malekzadeh and Pierre Hainaut
    Citation: BMC Cancer 2012 12:602
    Content type: Research article Published on:

  39. Caldesmon (CaD), a major actin-associated protein, is found in smooth muscle and non-muscle cells. Smooth muscle caldesmon, h-CaD, is a multifunctional protein, and non-muscle cell caldesmon, l-CaD, plays a role ...

    Authors: Kyung-Hee Kim, Seung-Gu Yeo, Won Ki Kim, Dae Yong Kim, Hyun Yang Yeo, Jun Pyu Hong, Hee Jin Chang, Ji Won Park, Sun Young Kim, Byung Chang Kim and Byong Chul Yoo
    Citation: BMC Cancer 2012 12:601
    Content type: Research article Published on:

  40. Mucin-1 is known to be over-expressed by various human carcinomas and is shed into the circulation where it can be detected in patient’s serum by specific anti-Mucin-1 antibodies, such as the tumour marker ass...

    Authors: Verena Engelstaedter, Sabine Heublein, Anamur Lan Schumacher, Miriam Lenhard, Helen Engelstaedter, Ulrich Andergassen, Margit Guenthner-Biller, Christina Kuhn, Brigitte Rack, Markus Kupka, Doris Mayr and Udo Jeschke
    Citation: BMC Cancer 2012 12:600
    Content type: Research article Published on:

  41. Androgen receptors (AR) are frequently expressed in breast cancers, but their implication in cancer growth is still controversial. In the present study, we further investigated the role of the androgen/AR path...

    Authors: Giorgio Secreto, Elisabetta Venturelli, Elisabetta Meneghini, Maria Luisa Carcangiu, Biagio Paolini, Roberto Agresti, Cristina Pellitteri, Franco Berrino, Massimo Gion, Patrizia Cogliati, Giuseppina Saragò and Andrea Micheli
    Citation: BMC Cancer 2012 12:599
    Content type: Research article Published on:

  42. Over recent years a number of novel therapies have shown promise in advanced renal cell carcinoma (RCC). Internationally the standard of care of first-line therapy is sunitinib™, after a clear survival benefit...

    Authors: Fiona J Collinson, Walter M Gregory, Chris McCabe, Helen Howard, Catherine Lowe, DrBarbara Potrata, Sandy Tubeuf, Pat Hanlon, Lucy McParland, T Wah, Peter J Selby, Jenny Hewison, Julia Brown and Janet Brown
    Citation: BMC Cancer 2012 12:598
    Content type: Study protocol Published on:

  43. Plasminogen activator inhibitor 1 (PAI-1) overexpression is an important prognostic and predictive biomarker in human breast cancer. SERBP1, a protein that is supposed to regulate the stability of PAI-1 mRNA, may...

    Authors: Nuran Bektas Serce, Andreas Boesl, Irina Klaman, Sonja von Serényi, Erik Noetzel, Michael F Press, Arno Dimmler, Arndt Hartmann, Jalid Sehouli, Ruth Knuechel, Matthias W Beckmann, Peter A Fasching and Edgar Dahl
    Citation: BMC Cancer 2012 12:597
    Content type: Research article Published on:

  44. Several studies have suggested a cancer risk reduction in statin users although the evidence remains weak for stomach cancer. The purpose of this study was to use an exact-matching case–control design to exami...

    Authors: Jeeyun Lee, Soo Hyeon Lee, Kyu Yeon Hur, Sook Young Woo, Sun Woo Kim and Won Ki Kang
    Citation: BMC Cancer 2012 12:596
    Content type: Research article Published on:

  45. Asbestos is classified as a human carcinogen, and studies have consistently demonstrated that workplace exposure to it increases the risk of developing lung cancer. Few studies have evaluated risks in populati...

    Authors: Paul J Villeneuve, Marie-Élise Parent, Shelley A Harris and Kenneth C Johnson
    Citation: BMC Cancer 2012 12:595
    Content type: Research article Published on:

  46. In the past few years, the number of clinical trials has increased rapidly in East Asia, especially for gastric and hepatobiliary cancer that are prevalent in Asian populations. However, the actual degree of u...

    Authors: Su Jin Lee, Lee Chun Park, Jeeyun Lee, Seonwoo Kim, Moon Ki Choi, Jung Yong Hong, Sylvia Park, Chi Hoon Maeng, Wonjin Chang, Young Saing Kim, Se Hoon Park, Joon Oh Park, Ho Yeong Lim, Won Ki Kang and Young Suk Park
    Citation: BMC Cancer 2012 12:594
    Content type: Research article Published on:

  47. To evaluate disease control, overall survival and prognostic factors in patients with locally recurrent rectal cancer after IOERT-containing multimodal therapy.

    Authors: Falk Roeder, Joerg-Michael Goetz, Gregor Habl, Marc Bischof, Robert Krempien, Markus W Buechler, Frank W Hensley, Peter E Huber, Juergen Weitz and Juergen Debus
    Citation: BMC Cancer 2012 12:592
    Content type: Research article Published on:

  48. Tamoxifen is used in hormone therapy for estrogen-receptor (ER)-positive breast cancer, but also has chemopreventative effects against ER-negative breast cancers. This study sought to investigate whether oral ...

    Authors: Xueying Sun, Ruohan Jiang, Aneta Przepiorski, Shiva Reddy, Kate P Palmano and Geoffrey W Krissansen
    Citation: BMC Cancer 2012 12:591
    Content type: Research article Published on:

  49. Sorafenib is an orally available kinase inhibitor with activity at Raf, PDGFβ and VEGF receptors that is licensed for the treatment of advanced renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC). Cu...

    Authors: BP Fairfax, S Pratap, ISD Roberts, J Collier, R Kaplan, AM Meade, AW Ritchie, T Eisen, VM Macaulay and A Protheroe
    Citation: BMC Cancer 2012 12:590
    Content type: Case report Published on:

  50. The p21 codon 31 single nucleotide polymorphism (SNP), rs1801270, has been linked to cervical cancer but with controversial results. The aims of this study were to investigate the role of p21 SNP-rs1801270 and...

    Authors: Ning Wang, Shizhuo Wang, Qiao Zhang, Yanming Lu, Heng Wei, Wei Li, Shulan Zhang, Duo Yin and Yangling Ou
    Citation: BMC Cancer 2012 12:589
    Content type: Research article Published on:

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