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  1. The oncogenic ether-à-go-go-1 potassium channel (EAG1) activity and expression are necessary for cell cycle progression and tumorigenesis. The active vitamin D metabolite, calcitriol, and astemizole, a promising ...

    Authors: Janice García-Quiroz, Rocío García-Becerra, Nancy Santos-Martínez, David Barrera, David Ordaz-Rosado, Euclides Avila, Ali Halhali, Octavio Villanueva, Maŕa J Ibarra-Sánchez, José Esparza-López, Armando Gamboa-Domínguez, Javier Camacho, Fernando Larrea and Lorenza Díaz
    Citation: BMC Cancer 2014 14:745
    Content type: Research article Published on:

  2. Castration resistant prostate cancer (CRPC) is a leading cause of cancer-related deaths in men. The primary cause of mortality and morbidity in patients is bone metastases and remodeling resulting in osteoblas...

    Authors: Jeetendra Eswaraka, Anand Giddabasappa, Guangzhou Han, Kush Lalwani, Koleen Eisele, Zheng Feng, Timothy Affolter, James Christensen and Gang Li
    Citation: BMC Cancer 2014 14:742
    Content type: Research article Published on:

  3. There is no consensus regarding resection of the primary tumour with few or absent symptoms in patients with synchronous unresectable metastatic colorectal cancer (CRC). A potential benefit of resection of the...

    Authors: Jorine ’t Lam - Boer, Linda Mol, Cornelis Verhoef, Anton F J de Haan, Mette Yilmaz, Cornelis J A Punt, Johannes H W de Wilt and Miriam Koopman
    Citation: BMC Cancer 2014 14:741
    Content type: Study protocol Published on:

  4. Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancers, and is the leading cause of cancer deaths. Radiation therapy (RT), alone or in combination with chemotherapy, is the standard of care for cu...

    Authors: Shankar Siva, Jason Callahan, Tomas Kron, Olga A Martin, Michael P MacManus, David L Ball, Rodney J Hicks and Michael S Hofman
    Citation: BMC Cancer 2014 14:740
    Content type: Study protocol Published on:

  5. MicroRNAs (miRNAs) are small, non-coding RNA molecules involved in post-transcriptional gene regulation and have recently been shown to play a role in cancer metastasis. In solid tumors, especially breast canc...

    Authors: Augusto LF Marino, Adriane F Evangelista, René AC Vieira, Taciane Macedo, Ligia M Kerr, Lucas Faria Abrahão-Machado, Adhemar Longatto-Filho, Henrique CS Silveira and Marcia MC Marques
    Citation: BMC Cancer 2014 14:739
    Content type: Research article Published on:

  6. Natural killer (NK) cells play a key role in non-specific immune response in different cancers, including pancreatic cancer. However the anti-tumor effect of NK cells decreases during pancreatic cancer progres...

    Authors: Yun-Peng Peng, Jing-Jing Zhang, Wen-biao Liang, Min Tu, Zi-Peng Lu, Ji-Shu Wei, Kui-Rong Jiang, Wen-Tao Gao, Jun-Li Wu, Ze-Kuan Xu, Yi Miao and Yi Zhu
    Citation: BMC Cancer 2014 14:738
    Content type: Research article Published on:

  7. Dose intense chemotherapy may improve efficacy with acceptable toxicity. A phase II study was conducted to determine the feasibility of a dose-intense two weekly schedule of capecitabine, oxaliplatin, and beva...

    Authors: Christopher GCA Jackson, Katrina Sharples, Paul I Thompson, Anne O’Donnell, Bridget Anne Robinson, David J Perez, Jacqui Adams, Richard Isaacs, Sanjeev Deva, Victoria A Hinder and Michael P Findlay
    Citation: BMC Cancer 2014 14:737
    Content type: Research article Published on:

  8. Breast metastasis from extramammary malignancy is uncommon and often presents diagnostic challenges. Herein, we report a case of a patient with metachronous isolated breast metastasis from pulmonary adenocarci...

    Authors: Young Ju Jeong, Jin Gu Bong, Hoon Kyu Oh, Sung Hwan Park, Sung Min Kang and Sung Hwa Bae
    Citation: BMC Cancer 2014 14:736
    Content type: Case report Published on:

  9. Luminal, estrogen receptor-positive breast cancers represent more than 70% of cases. Despite initial good prognoses one third of Luminal cancers eventually recur locally or at distant sites and exhibit hormone...

    Authors: Mauricio P Pinto, Wendy W Dye, Britta M Jacobsen and Kathryn B Horwitz
    Citation: BMC Cancer 2014 14:735
    Content type: Research article Published on:

  10. Cancer stem cells are hypoxia-resistant and present a preponderant glycolytic metabolism. These characteristics are also found in basal-like breast carcinomas (BLBC), which show increased expression of cancer ...

    Authors: Bárbara Sousa, Ana Sofia Ribeiro, Ana Rita Nobre, Nair Lopes, Diana Martins, Céline Pinheiro, André Filipe Vieira, André Albergaria, René Gerhard, Fernando Schmitt, Fátima Baltazar and Joana Paredes
    Citation: BMC Cancer 2014 14:734
    Content type: Research article Published on:

  11. Estrogen receptor positive breast cancers have high recurrence rates despite tamoxifen therapy. Breast cancer stem/progenitor cells (BCSCs) initiate tumors, but expression of estrogen (ER) or progesterone rece...

    Authors: Robynn V Schillace, Amy M Skinner, Rodney F Pommier, Steven O’Neill, Patrick J Muller, Arpana M Naik, Juliana E Hansen and SuEllen J Pommier
    Citation: BMC Cancer 2014 14:733
    Content type: Research article Published on:

  12. Prognostic value of enhanced COX-2 expression in breast cancer has been controversial for a long time. The opinions vary widely between studies. Moreover, significant majority of studies considered only COX-2 ...

    Authors: Justyna Urban, Łukasz Kuźbicki, Grzegorz Szatkowski, Agata Stanek-Widera, Dariusz Lange and Barbara W Chwirot
    Citation: BMC Cancer 2014 14:732
    Content type: Research article Published on:

  13. Many patients with cancer suffer from distress, anxiety and depression. However, studies on patients with brain metastases are lacking. In this exploratory study we prospectively assessed distress, anxiety and...

    Authors: Marie-Christine Cordes, Angela Scherwath, Tahera Ahmad, Ansa Maer Cole, Gundula Ernst, Karina Oppitz, Heinrich Lanfermann, Michael Bremer and Diana Steinmann
    Citation: BMC Cancer 2014 14:731
    Content type: Research article Published on:

  14. Axillary lymph node (ALN) status is an important prognostic factor for breast cancer. We retrospectively used contrast-enhanced computed tomography (CE-CT) to evaluate the presence of ALN, metastasis based on ...

    Authors: Masakazu Urata, Yuko Kijima, Munetsugu Hirata, Yoshiaki Shinden, Hideo Arima, Akihiro Nakajo, Chihaya Koriyama, Takaaki Arigami, Yoshikazu Uenosono, Hiroshi Okumura, Kosei Maemura, Sumiya Ishigami, Heiji Yoshinaka and Shoji Natsugoe
    Citation: BMC Cancer 2014 14:730
    Content type: Research article Published on:

  15. The development of hepatic cancer is tightly regulated by multiple intracellular signaling pathways. Therefore, most currently-used anti-tumor agents, which typically target single intracellular pathway, might...

    Authors: Jiumao Lin, Aling Shen, Hongwei Chen, Jun Liao, Teng Xu, Liya Liu, Jing Lin and Jun Peng
    Citation: BMC Cancer 2014 14:729
    Content type: Research article Published on:

  16. Obesity is a risk factor for developing pancreatic cancer. We investigated the impact of obesity on survival in patients diagnosed with locally advanced or metastatic pancreatic cancer.

    Authors: Benjamin Kasenda, Annatina Bass, Dieter Koeberle, Bernhard Pestalozzi, Markus Borner, Richard Herrmann, Lorenz Jost, Andreas Lohri and Viviane Hess
    Citation: BMC Cancer 2014 14:728
    Content type: Research article Published on:

  17. Mutations in the activation segment of the v-raf murine sarcoma viral oncogene homolog B (BRAF) gene are present in approximately 50% of melanomas. The selective BRAF inhibitor vemurafenib has demonstrated signif...

    Authors: Stéphanie Trudel, Norbert Odolczyk, Julie Dremaux, Jérôme Toffin, Aline Regnier, Henri Sevestre, Piotr Zielenkiewicz, Jean-Philippe Arnault and Brigitte Gubler
    Citation: BMC Cancer 2014 14:727
    Content type: Case report Published on:

  18. Regulated intramembrane proteolysis of Epithelial cell adhesion molecule (EpCAM) results in release of its intracellular domain (Ep-ICD) which triggers oncogenic signalling. The clinical significance of Ep-ICD...

    Authors: Gunjan Srivastava, Jasmeet Assi, Lawrence Kashat, Ajay Matta, Martin Chang, Paul G Walfish and Ranju Ralhan
    Citation: BMC Cancer 2014 14:726
    Content type: Research article Published on:

  19. Pancreatic cancer is frequently resistant to cancer therapeutics. Smoking and alcoholism are risk factors and pancreatic cancer patients often undergo nicotine replacement therapy (NRT) and treatment for alcoh...

    Authors: Jheelam Banerjee, Hussein AN Al-Wadei, Mohammed H Al-Wadei, Koami Dagnon and Hildegard M Schuller
    Citation: BMC Cancer 2014 14:725
    Content type: Research article Published on:

  21. Kiss-1 and Kiss-1R have been suggested as a novel pair of metastasis suppressors for several human solid tumours, however, their role in colorectal cancer remains largely unknown. Therefore, the aim of this st...

    Authors: Ke Ji, Lin Ye, Fiona Ruge, Rachel Hargest, Malcolm D Mason and Wen G Jiang
    Citation: BMC Cancer 2014 14:723
    Content type: Research article Published on:

  22. Cancer stem cells (CSCs) are thought to play important roles in therapy-resistance. In this study, we induced cancer stem-like cells from hepatocellular carcinoma (HCC) cell lines using a unique medium, and ex...

    Authors: Noriaki Hashimoto, Ryouichi Tsunedomi, Kiyoshi Yoshimura, Yusaku Watanabe, Shoichi Hazama and Masaaki Oka
    Citation: BMC Cancer 2014 14:722
    Content type: Research article Published on:

  23. Hepatitis B Virus (HBV) X protein (HBx) is known to be involved in the initiation and progression of hepatocellular carcinoma (HCC) through modulation of host gene response. Alterations in miRNA expressions ar...

    Authors: Manikankana Bandopadhyay, Arup Banerjee, Neelakshi Sarkar, Rajesh Panigrahi, Sibnarayan Datta, Ananya Pal, Shivram Prasad Singh, Avik Biswas, Shekhar Chakrabarti and Runu Chakravarty
    Citation: BMC Cancer 2014 14:721
    Content type: Research article Published on:

  24. Authors: Mauricette Michallet, Elisabeth Luporsi, Pierre Soubeyran, Nadia Ali Amar, Vincent Boulanger, Miguel Carreiro, Louis-Marie Dourthe, Jean-Luc Labourey, Daniel Lepille, Frédéric Maloisel, Jean-Loup Mouysset, Sophie Nahon, Bérengère Narciso, Pierre Nouyrigat, Raouf Radji, Nacéra Sakek…
    Citation: BMC Cancer 2014 14:720
    Content type: Erratum Published on:

    The original article was published in BMC Cancer 2014 14:503

  25. Stereotactic body radiation therapy (SBRT) has emerged as an alternative treatment for patients with early stage non-small cell lung cancer (NSCLC) or metastatic pulmonary tumors. However, for isolated lung me...

    Authors: Weijie Xiong, Qingfeng Xu, Yong Xu, Changjin Sun, Na Li, Lin Zhou, Yongmei Liu, Xiaojuan Zhou, Yongsheng Wang, Jin Wang, Sen Bai, You Lu and Youling Gong
    Citation: BMC Cancer 2014 14:719
    Content type: Research article Published on:

  26. Glioblastoma is a highly malignant brain tumor for which no cure is available. To identify new therapeutic targets, we performed a mutation analysis of kinase genes in glioblastoma.

    Authors: Fonnet E Bleeker, Simona Lamba, Carlo Zanon, Remco J Molenaar, Theo JM Hulsebos, Dirk Troost, Angela A van Tilborg, W Peter Vandertop, Sieger Leenstra, Cornelis JF van Noorden and Alberto Bardelli
    Citation: BMC Cancer 2014 14:718
    Content type: Research article Published on:

  27. There is currently no consensus on the correlations between androgen concentrations in prostate tissue and blood and stage and pathological grade of prostate cancer. In this study, we used a newly-developed ul...

    Authors: Yasuhide Miyoshi, Hiroji Uemura, Susumu Umemoto, Kentaro Sakamaki, Satoshi Morita, Kazuhiro Suzuki, Yasuhiro Shibata, Naoya Masumori, Tomohiko Ichikawa, Atsushi Mizokami, Yoshiki Sugimura, Norio Nonomura, Hideki Sakai, Seijiro Honma, Masaoki Harada and Yoshinobu Kubota
    Citation: BMC Cancer 2014 14:717
    Content type: Research article Published on:

  28. Glioblastoma multiforme (GBM) is very difficult to treat with conventional anti-cancer/anti-apoptotic drugs. We tested the hypothesis that inhibition of Na+/K+-ATPase causes a mixed or hybrid form of concurrent a...

    Authors: Dongdong Chen, Mingke Song, Osama Mohamad and Shan Ping Yu
    Citation: BMC Cancer 2014 14:716
    Content type: Research article Published on:

  29. Variation in tumor biology in African-American (AA) and Caucasian (CAU) women with breast cancer is poorly defined. Activated leukocyte cell adhesion molecule (ALCAM) is a bad prognostic factor of breast cance...

    Authors: Fang Tan, Marina Mosunjac, Amy L Adams, Beverly Adade, Oleyad Taye, Yijuan Hu, Monica Rizzo and Solomon F Ofori-Acquah
    Citation: BMC Cancer 2014 14:715
    Content type: Research article Published on:

  30. MicroRNAs (miRNAs) offer great potential as cancer biomarkers. The importance of miRNAs profiling in tissue and body fluids in colorectal cancer (CRC) have been addressed respectively in many studies. The purp...

    Authors: Lingling Xu, Minzhe Li, Min Wang, Dong Yan, Guosheng Feng and Guangyu An
    Citation: BMC Cancer 2014 14:714
    Content type: Research article Published on:

  31. Transduction of human mesenchymal stem cells (MSCs) with type 5 adenoviruses (Ad5) is limited in the efficacy because of the poor expression level of the coxsackie adenovirus receptor (CAR) molecules. We exami...

    Authors: Takeo Suzuki, Kiyoko Kawamura, Quanhai Li, Shinya Okamoto, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Naoto Yamaguchi and Masatoshi Tagawa
    Citation: BMC Cancer 2014 14:713
    Content type: Research article Published on:

  32. It is estimated that 20% of all cancer cases are caused by obesity. Vitamin D is thought to be one of the mechanisms underlying this association. This review aims to summarise the evidence for the mediating ef...

    Authors: Thurkaa Shanmugalingam, Danielle Crawley, Cecilia Bosco, Jennifer Melvin, Sabine Rohrmann, Simon Chowdhury, Lars Holmberg and Mieke Van Hemelrijck
    Citation: BMC Cancer 2014 14:712
    Content type: Research article Published on:

  33. After breast-conserving radiation therapy most patients experience acute skin toxicity to some degree. This may impair patients’ quality of life, cause pain and discomfort. In this study, we investigated treat...

    Authors: Sofie De Langhe, Thomas Mulliez, Liv Veldeman, Vincent Remouchamps, Annick van Greveling, Monique Gilsoul, Eline De Schepper, Kim De Ruyck, Wilfried De Neve and Hubert Thierens
    Citation: BMC Cancer 2014 14:711
    Content type: Research article Published on:

  35. Patients with malignant mesothelioma have a poor prognosis and only 40% respond to first line treatment; a combination of pemetrexed and cisplatin or carboplatin. We used primary malignant mesothelioma cells a...

    Authors: Adam Szulkin, Rita Ötvös, Carl-Olof Hillerdal, Aytekin Celep, Eviane Yousef-Fadhel, Henriette Skribek, Anders Hjerpe, László Székely and Katalin Dobra
    Citation: BMC Cancer 2014 14:709
    Content type: Research article Published on:

  36. Dysregulation of transcriptional programs leads to cell malfunctioning and can have an impact in cancer development. Our study aims to characterize global differences between transcriptional regulatory program...

    Authors: David Cordero, Xavier Solé, Marta Crous-Bou, Rebeca Sanz-Pamplona, Laia Paré-Brunet, Elisabet Guinó, David Olivares, Antonio Berenguer, Cristina Santos, Ramón Salazar, Sebastiano Biondo and Víctor Moreno
    Citation: BMC Cancer 2014 14:708
    Content type: Research article Published on:

  37. Renal cell carcinoma (RCC) has a higher incidence in blacks than in whites. Physical activity may influence the risk of renal cell cancer, but the evidence is inconsistent. No previous study has investigated t...

    Authors: Qian Xiao, Linda Liao, Charles E Matthews, Wong-Ho Chow, Faith Davis, Kendra Schwartz, Mark Purdue, Jonathan N Hofmann and Joanne Colt
    Citation: BMC Cancer 2014 14:707
    Content type: Research article Published on:

  38. Chemoradiotherapy (CRT) is an effective modality for stage I esophageal squamous cell carcinoma (ESCC). However, salvage treatments are often required even if complete response (CR) has been achieved. To this ...

    Authors: Yoshito Hayashi, Tsutomu Nishida, Masahiko Tsujii, Shusaku Tsutsui, Katsumi Yamamoto, Fumiaki Isohashi, Makoto Yamasaki, Hiroshi Miyata, Motohiko Kato, Takuya Yamada, Shinichiro Shinzaki, Hideki Iijima, Kazuhiko Ogawa, Yuichiro Doki and Tetsuo Takehara
    Citation: BMC Cancer 2014 14:706
    Content type: Research article Published on:

  40. Disorders of cell adhesion are critical steps in cancer progression in which varieties of markers including cadherins are involved in.Btbd7 was found to inhibit E-cadherin expression in MDCK cells and play imp...

    Authors: Chuifeng Fan, Yuan Miao, Xiupeng Zhang, Di Liu, Guiyang Jiang, Xuyong Lin, Qiang Han, Lan Luan, Zhonghai Xu and Enhua Wang
    Citation: BMC Cancer 2014 14:704
    Content type: Research article Published on:

  42. Breast cancer mortality steadily declined from the 1990s and this has been attributed to early detection and/or to improvements in therapy. Which of those two has had the greater impact is a subject of content...

    Authors: Romano Demicheli and Federico Ambrogi
    Citation: BMC Cancer 2014 14:702
    Content type: Research article Published on:

  43. Ductal carcinomas of the parotid gland are rare, highly aggressive, have a poor prognosis and are histologically similar to Ductal Breast Cancer. We report what we believe to be the first case in literature of...

    Authors: Saúl Campos-Gómez, Jose H Flores-Arredondo, Rita Dorantes-Heredia, Mónica Chapa-Ibargüengoitia and Roberto de la Peña-Lopez
    Citation: BMC Cancer 2014 14:701
    Content type: Case report Published on:

  44. The population of elderly people is increasing and so is the population of breast cancer patients aged ≥80 years. The aim of our retrospective study was to identify independent prognostic factors for the durat...

    Authors: Nikola Besic, Hana Besic, Barbara Peric, Gasper Pilko, Rok Petric, Jan Zmuc, Radan Dzodic and Andraz Perhavec
    Citation: BMC Cancer 2014 14:700
    Content type: Research article Published on:

  45. Aptamers have emerged as excellent molecular probes for cancer diagnosis and therapy. The aim of the current study was to determine the feasibility of using DNA aptamer cy-apt 20 developed by live cell-SELEX f...

    Authors: Hong-Yong Cao, Ai-Hua Yuan, Wei Chen, Xue-Song Shi and Yi Miao
    Citation: BMC Cancer 2014 14:699
    Content type: Research article Published on:

  46. Little aetiological epidemiological research has been undertaken for major cancers occurring in teenagers and young adults (TYA). Population mixing, as a possible proxy for infectious exposure, has been well r...

    Authors: Marlous van Laar, Daniel P Stark, Patricia McKinney, Roger C Parslow, Sally E Kinsey, Susan V Picton and Richard G Feltbower
    Citation: BMC Cancer 2014 14:698
    Content type: Research article Published on:

  47. Lung cancer remains one of the most prevalent forms of cancer. Radiotherapy, with or without other therapeutic modalities, is an effective treatment. Our objective was to report on the use of radiotherapy for ...

    Authors: Isabel Tovar, Jose Expósito, Javier Jaén, Enrique Alonso, Miguel Martínez, Rosa Guerrero, Juan P Arrebola and Rosario Del Moral
    Citation: BMC Cancer 2014 14:697
    Content type: Research article Published on:

  48. In Morocco, knowledge of cancer risk factors, a crucial element in the process of behavioral change, has never been evaluated. This study aims to provide information on the level of awareness of cancer risk fa...

    Authors: Karima El Rhazi, Bahia Bennani, Samira El Fakir, Ahmadou Boly, Rachid Bekkali, Ahmed Zidouh and Chakib Nejjari
    Citation: BMC Cancer 2014 14:695
    Content type: Research article Published on:

  49. Humans and dogs are affected by squamous cell carcinomas of the oral cavity (OSCC) in a considerably high frequency. The high mobility group A2 (HMGA2) protein was found to be highly expressed in human OSCC an...

    Authors: Katharina Anna Sterenczak, Andre Eckardt, Andreas Kampmann, Saskia Willenbrock, Nina Eberle, Florian Länger, Sven Kleinschmidt, Marion Hewicker-Trautwein, Hans Kreipe, Ingo Nolte, Hugo Murua Escobar and Nils Claudius Gellrich
    Citation: BMC Cancer 2014 14:694
    Content type: Research article Published on:

  50. Acute promyelocytic leukemia (APL) is characterized by the reciprocal translocation t(15;17), which fuses PML with retinoic acid receptor alpha (RARα). Although PML-RARα is crucially important for pathogenesis...

    Authors: Chengwu Zeng, Yan Xu, Ling Xu, Xibao Yu, Jingjing Cheng, Lijian Yang, Shaohua Chen and Yangqiu Li
    Citation: BMC Cancer 2014 14:693
    Content type: Research article Published on:

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