- Research article
- Open Access
- Open Peer Review
BiOsimilaRs in the management of anaemia secondary to chemotherapy in HaEmatology and Oncology: results of the ORHEO observational study
- Mauricette Michallet1Email author,
- Elisabeth Luporsi2,
- Pierre Soubeyran3,
- Nadia Ali Amar4,
- Vincent Boulanger5,
- Miguel Carreiro6,
- Louis-Marie Dourthe7,
- Jean-Luc Labourey5, 8,
- Daniel Lepille9,
- Frédéric Maloisel7,
- Jean-Loup Mouysset10,
- Sophie Nahon11,
- Bérengère Narciso12,
- Pierre Nouyrigat13,
- Raouf Radji14,
- Nacéra Sakek15,
- Hélène Albrand16 and
- The ORHEO study group
© Michallet et al.; licensee BioMed Central Ltd. 2014
- Received: 4 February 2014
- Accepted: 1 July 2014
- Published: 10 July 2014
The Erratum to this article has been published in BMC Cancer 2014 14:720
The approval of epoetin biosimilars in the European Union requires extensive scientific evaluation and stringent regulatory procedures, including post-marketing studies. The ORHEO (place of biOsimilaRs in the therapeutic management of anaemia secondary to chemotherapy in HaEmatology and Oncology) study was an observational, longitudinal, multicentre study performed in France to evaluate the efficacy and safety of biosimilar epoetins for the treatment of chemotherapy-induced anaemia (CIA) in the clinical setting.
Patients >18 years with CIA (haemoglobin [Hb] <11 g/dL) in association with solid tumours, lymphoma or myeloma and eligible for treatment with an epoetin biosimilar were included in this study. Patient characteristics were recorded at baseline along with anaemia-related information, such as observed and target Hb (as chosen by the treating clinician), brand and dose of epoetin biosimilar prescribed, and details of any other treatments. Patients were then followed-up at 3 and 6 months. The primary endpoint was Hb response (defined as Hb reaching ≥10 g/dL, an increase of Hb ≥1 g/dL since inclusion visit or reaching physician-defined target Hb, with no blood transfusions in the 3 weeks prior to measurement). Other endpoints included adverse events, achievement of target Hb and associated treatments.
Overall, 2333 patients >18 years (mean age 66.5 years) with CIA (haemoglobin [Hb] <11 g/dL) in association with solid tumours, lymphoma or myeloma and eligible for biosimilar epoetin treatment were included. 99.9% of patients received epoetin zeta (median dose 30,000 IU/week). Mean baseline Hb was 9.61 g/dL, with 35.6% of patients having moderate anaemia (Hb 8–9.5 g/dL). Hb response was achieved in 81.6% and 86.5% of patients at 3 and 6 months, respectively. Overall mean change in Hb level was 1.52 ± 1.61 and 1.72 ± 1.61 g/dL at 3 and 6 months, respectively. Transfusion and thromboembolic event rates were 9.4% and 2.4% at 3 months, and 5.8% and 1.5% at 6 months, respectively.
Epoetin zeta was effective and well tolerated in the management of CIA in patients with solid tumours, lymphoma and myeloma.
Trial registration number: NCT02140736 (date of registration: 14 May 2014).
Supportive therapy for patients undergoing chemotherapy can be of great benefit in alleviating undesirable consequences of this specific treatment. One such consequence is chemotherapy-induced anaemia (CIA), a common complication of myelosuppressive chemotherapy across a large range of cancer types. According to the European Cancer Anaemia Survey (ECAS), 67.0% of cancer patients were anaemic (haemoglobin [Hb] levels of <12 g/dL) during a 6-month period . Patients presenting with CIA often suffer from fatigue and impaired quality of life (QoL) . Successful Hb response through supportive therapy has been demonstrated to improve fatigue and QoL significantly in patients with CIA . CIA is also independently associated with reduced survival rates for patients with solid tumours, lymphoma or myeloma , further highlighting the importance of providing appropriate supportive care.
Currently, anaemia treatment may involve red blood cell (RBC) transfusions, iron supplementation (in absolute or functionally iron-deficient anaemia) and erythropoiesis-stimulating agents (ESAs) . RBC transfusions can provide a rapid, transient increase in Hb; however, as repeated transfusions are required to maintain Hb levels, this treatment is usually reserved for more severe cases of anaemia . Furthermore, transfusions continue to be associated with risk of transfusion reactions or infections . A systematic study of 125,223 patients undergoing major general surgery showed that transfusions were associated with a significantly (P < 0.05) increased risk of mortality, composite morbidity, pneumonia and sepsis . These results were further demonstrated in a long-term review of 10,289 patients for up to 10 years post-coronary artery bypass surgery, in which RBC transfusion was associated with significant reductions in early (up to 6 months) and late (up to 10 years) survival when controlling for demographics, comorbidities, operative factors and early hazard for death .
ESAs are biological analogues of human erythropoietin produced in cell lines using recombinant DNA technology . The major goals of ESA use are sustained correction of anaemia and resultant improvement in QoL for patients, while also reducing the need for RBC transfusions . The first ESA was epoetin alfa; second and third generation ESAs have since been developed with a longer half-life than first-generation ESAs [10, 11]. The impact of ESAs on overall patient survival and mortality in anaemia associated with cancer has been the subject of several trials and meta-analyses . A large meta-analysis of 13,933 patients in 53 trials indicated that use of ESAs led to a reduction in survival and increased mortality in patients with cancer, with the authors recommending that the observed risks be measured against the benefits of ESA treatment . However, while it cannot be ruled out, the same risk has yet to be confirmed in patients receiving chemotherapy .
Since the patent expiry of epoetin alfa, several biosimilar epoetins have become available . Biosimilars, as defined by EU legislation, are therapeutic proteins exhibiting comparable quality, and non-clinical and clinical similarity to an existing reference biological medicine whose patent has expired. These biosimilars have undergone a rigorous preclinical, clinical and post-approval process to ensure that the mode of action, efficacy and safety are equivalent to originator products . As part of this process, the Committee for Medicinal Products for Human Use (CHMP) recommends continuing post-approval studies of biosimilars to evaluate safety . Once a product has been approved, such studies form part of an ongoing risk management plan through collection of real-life clinical evidence.
The present study, ORHEO (biOsimilaRs in the management of anaemia secondary to chemotherapy in HaEmatology and Oncology), was a post-marketing study aimed at observing Hb response in CIA patients presenting with various solid tumours, lymphoma or myeloma when treated with biosimilar epoetin alfa.
This was an observational, non-interventional, longitudinal, national, multicentre study (NCT02140736). After screening for inclusion and exclusion criteria, patients were enrolled in the study and followed-up for 6 months over three visits: inclusion visit (D0), 3-month follow-up visit (M3) and 6-month end-of-study visit (M6). The study protocol was reviewed and approved by the ethics committee (Advisory Committee on Information Processing Research in the Field of Health [Comité consultatif sur le traitement de l'information en matière de recherche dans le domaine de la santé], Ministry of Higher Education and Research, INSERM 700, Faculty of Medicine, Paris, France). Results were recorded on case report forms. As this is a post-approval, observational, non-interventional study only verbal consent was obtained in compliance with French law for such studies. Informed patient consent was obtained verbally prior to participation in the study and written consent was signed by the physician.
Inclusion criteria included patients at least 18 years of age presenting with CIA (irrespective of chemotherapy cycle) associated with solid tumours, lymphomas or myelomas and eligible for treatment with an epoetin alfa biosimilar.
Exclusion criteria included absence of chemotherapy treatment, presence of any contraindications for epoetin, hypersensitivity to any of the treatment components, previously confirmed pure red cell aplasia (PRCA), uncontrolled hypertension, lack of access to anti-thrombotic prophylaxis, or involvement in another biosimilar epoetin study.
Primary and secondary objectives
The primary objective of the study was to observe response to treatment with an epoetin alfa biosimilar in patients presenting CIA in association with solid tumours, lymphoma or myeloma.
Secondary objectives included changes in biological indicators such as Hb, haematocrit, reticulocytes, serum iron, ferritin and blood pressure; disease outcome and the safety profile of epoetin alfa biosimilars. CIA was defined according to the World Health Organization (WHO) criteria , measured prior to starting treatment. A patient was described as a ‘responder’ to treatment with an epoetin biosimilar if Hb levels were at least equal to 10 g/dL; if there had been an increase in Hb levels of at least 1 g/dL since the inclusion visit; or if Hb level reached target level set by the physician on D0, without any blood transfusions in the 3 weeks prior to measurement (transfusion details were reported by investigators). In patients with baseline Hb levels at least equal to 10 g/dL, only those who reached their Hb target or had an Hb increase >1 g/dL were regarded as responders. Disease outcomes were reported using the WHO performance score .
All statistical analyses were performed on the per protocol population. This excluded patients with missing baseline Hb values, patients for whom age was not recorded, patients who had not initiated chemotherapy at baseline, patients who were not receiving an epoetin biosimilar at baseline and patients who switched to another epoetin treatment between baseline and Month 6. In addition, patients with a disease other than those described in the protocol were excluded. The rates of Hb responders were calculated at each visit with 95% confidence intervals, as well as logistic regressions for prognostic factors of Hb response, using SAS® software (9.2 release).
Patient characteristics at baseline
Age, mean ± SD (years)
66.49 ± 11.77
Patients with solid tumours, mean (years)
Patients with lymphoma, mean (years)
Patients with myeloma, mean (years)
Hb, mean ± SD (g/dL)
9.59 ± 0.88
sBP, mean ± SD (mmHg)
125.75 ± 14.48
dBP, mean ± SD (mmHg)
74.18 ± 9.79
Malignancies, n (%)
Solid tumours, n (%)
Lymphoma, n (%)
Myeloma, n (%)
Height, mean ± SD (cm)
166.35 ± 8.72
Weight, mean ± SD (kg)
67.46 ± 14.23
BMI, mean ± SD (kg/m2)
24.33 ± 4.62
Biosimilar epoetin treatment
Almost all (99.9%) patients received the biosimilar Retacrit® (epoetin zeta, Hospira); the remaining three patients received Binocrit® (epoetin alfa, Sandoz). The median dose of biosimilar epoetin was 30,000 IU/week during the course of the study. Most patients (99.7%) received biosimilar epoetin via the subcutaneous route and almost all (97.97%) received single weekly biosimilar epoetin injections.
Between inclusion and M6, a total of 1202 patients discontinued epoetin treatment. Of patients that discontinued, 39.5% of stops were due to satisfactory Hb being met, 26.6% were due to stopping or changing chemotherapy treatment, 14.9% were due to satisfactory Hb being reached and cessation of chemotherapy, 10.8% were due to inefficacy and 1.9% stopped due to an adverse effect.
29.54 ± 4.12 (2158)
34.41 ± 5.78 (1839)
34.90 ± 6.03 (1419)
53083.10 ± 43772.32 (330)
57478.34 ± 47391.55 (228)
52803.71 ± 52301.40 (146)
Iron (μg/100 mL)
94.96 ± 129.22 (546)
140.39 ± 152.77 (295)
144.98 ± 152.96 (182)
510.55 ± 629.61 (555)
512.83 ± 801.58 (301)
390.82 ± 466.91 (214)
125.75 ± 14.48 (1934)
125.58 ± 15.80 (1675)
126.04 ± 15.41 (1353)
74.18 ± 9.79 (1930)
74.51 ± 10.31 (1675)
74.33 ± 10.02 (1351)
Clinically significant adverse events
Thromboembolic events (%)
Local intolerability (%)
Rise in blood pressure (%)
Overall treatment outcomes
Associated treatments included antithrombotic agents (12% overall), IV iron (10.3% overall), oral iron (16.3%), folates (6.6% overall), vitamin B (4.3% overall) with a small proportion taking other vitamins (1.6% overall). A further 17.1% of patients were reported as being on ‘other treatments’.
Anaemia is a common complication of chemotherapy treatment. The advent of ESAs has led to a reduction in transfusion requirements, improved QoL and reduced fatigue for patients with CIA . An important limitation of ESAs and biological medicines in general remains the high cost, which may limit access in some countries . EU-approved biosimilar medicines can offer physicians the reassurance of rigorous comparability studies and extensive clinical and post-marketing surveillance programmes, in addition to cost savings due to lower development costs. Post-approval studies are an important aspect of post-approval efficacy and safety assessment of biosimilar medicines. This study forms part of an ongoing surveillance programme for epoetin zeta, a biosimilar of epoetin alfa.
The primary objective of this observational study was to record the rate of response to treatment of CIA with biosimilar epoetins in the oncology and onco-haematology settings. The definitions of Hb response utilised herein reflect the nature of this study, as it not only includes achieving target Hb but also clinically significant increases in Hb (achievement of 10 g/dL, or an increase in 1 g/dL from inclusion). The results of this study contribute to the growing body of evidence regarding the efficacy and safety of epoetin biosimilars in oncology.
The efficacy results reported herein correlate closely with previous research on epoetin zeta. A phase III non-controlled study of epoetin zeta in CIA over a 12-week period reported a mean Hb increase of 1.8 g/dL in the intention-to-treat (ITT) population, with 81.5% of patients achieving ≥1 g/dL Hb increase , both outcomes being similar to the findings here. This was the first open-label study on biosimilars conducted in Europe, and while more are currently planned or underway, ORHEO remains the largest with regard to patient numbers. Mean Hb response reported in the current study is similar to that reported for epoetin alfa in CIA associated with multiple myeloma .
The rate of Hb response showed a reduction at M6 for patients with myeloma compared to M3. Myeloma therapy is associated with a relatively high risk of deep vein thrombosis, particularly in the case of thalidomide-anthracycline regimens . A possible reason for the reduction in Hb response noted here could be the setting of more conservative treatment targets due to thromboembolic risk associated with myeloma chemotherapy and the disease itself.
No unexpected adverse events (AEs) were seen during the course of this study. The overall rate of treatment-related AEs was similar to that reported previously for epoetin zeta (10.4%). The rate of thromboembolic events (3.55%) was lower than reported previously for epoetin zeta (4.2%)  and epoetin alfa (4.0%). Patient death was the main reason for discontinuing this study. No deaths were considered related to treatment, and the death rate in the current study can be attributed to the characteristics of the population, particularly the high rate of metastatic cancer at baseline.
As part of this study, WHO performance scale data and disease progression were collected to give context to Hb response rates reported. At baseline, 73.0% of patients were characterised by a WHO performance status of 0 or 1, compared to 68.3% at M3 and 69.7% at M6. Evidence suggests Hb levels correlate with WHO performance status , and while it is hard to distinguish changes due to disease progression and changes due to improvement in Hb, the number of patients with a WHO performance status of 0 increased at both M3 and M6, indicating that some patients felt more physically able upon completion of the study. In terms of disease progression, an improvement in disease state was considerably more common in patients with a lymphoma, at M6 (60.9%). This could be a result of the efficacy/safety profiles of treatments in this group. Any improvement or exacerbation in disease outcomes should not be considered related to epoetin treatment. Such outcomes are confounded by patient characteristics such as age and disease status, as well as the nature of chemotherapy regimens, which vary considerably, particularly in the case of the solid tumour category.
This manuscript reports the results of an observational study. It is therefore difficult to address potential confounding factors surrounding treatment. However, it is anticipated that the ORHEO study can complement the findings of controlled clinical trials through offering real-life treatment observation. There was a significant disparity between the numbers of patients with solid tumours compared to those with myeloma or lymphoma, which corresponds well with the relative epidemiology of these cancer types in Europe [24, 25]. The definition of response in this study relates to clinically meaningful change in Hb, as befits the real-life setting and observational nature. As such, the rate of response should not be compared with that reported in randomised controlled clinical trials. One important limitation in this study was the lack of representation from biosimilar epoetins other than Retacrit. This reflects availability at the centres involved during the course of the study, and is not through deliberate omission or inherent study design.
Given the negative impact anaemia has on the QoL and overall survival in most cancer types [2, 3], it is not surprising that European guidelines recommend ESA treatment to correct CIA and reduce the need for transfusion . Guidance from the EMA states that in patients with non-myeloid malignancies treated with chemotherapy and an Hb level of <10 g/dL, treatment with ESAs might be considered to increase Hb to ≤12 g/dL or to prevent further decline in Hb. In patients treated with curative intent, ESAs should be used with caution. Furthermore, the use of ESAs should be carefully reconsidered in patients with a high risk of thromboembolic events. ESAs have been of great use to vast numbers of cancer patients receiving chemotherapy and are associated with patient benefits such as freedom from RBC transfusion and improvements in QoL. However, biological medicines such as recombinant ESAs are costly. The introduction of biosimilar medicines has the potential to provide cost competition and reduce cost to the payer due to their lower development costs . Indeed, a recent cost-efficiency study conducted in France, Germany, Italy, Spain, and the UK compared various regimens of biosimilar and originator ESAs in the management of CIA . Biosimilar ESA therapy was consistently cost-efficient over treatment with originator products under both fixed and weight-based dosing scenarios. The cost benefits of biosimilar ESAs may therefore increase patient access to this important form of treatment. However, physicians should not be obliged to prescribe biosimilars for purely cost reasons; only on proof of quality, efficacy and safety should biosimilars be considered a viable option. This study adds to the body of evidence supporting the efficacy and safety of the biosimilar ESA epoetin zeta in patients with CIA.
This study, the largest of its type, demonstrated a high rate of response to epoetin zeta treatment in a large patient population with CIA. The rate of thromboembolic events was lower than previously observed for this treatment, while no unexpected treatment-related AEs were identified.
Observational studies present a valuable means of assessing efficacy and safety under clinical conditions and complement the current body of data derived from randomised controlled trials.
This study assessed the clinical profile of biosimilar epoetin zeta as part of an ongoing commitment to post-marketing observation, and demonstrated that epoetin zeta is well-tolerated and efficacious in treating anaemia in cancer patients with CIA.
The authors gratefully acknowledge the patients and clinical investigators who participated in this trial. Medical writing and editorial assistance was provided by Dr Marion James, apothecom scopemedical ltd, funded by Hospira Ltd. Statistical analyses were performed by Clinact, funded by Hospira Ltd.
This trial was funded by Hospira SAS France.
- Ludwig H, Van Belle S, Barrett-Lee P, Birgegård G, Bokemeyer C, Gascón P, Kosmidis P, Krzakowski M, Nortier J, Olmi P, Schneider M, Schrijvers D: The European Cancer Anaemia Survey (ECAS): a large, multinational, prospective survey defining the prevalence, incidence, and treatment of anaemia in cancer patients. Eur J Cancer. 2004, 40: 2293-2306.View ArticlePubMedGoogle Scholar
- Cella D, Kallich J, McDermott A, Xu X: The longitudinal relationship of hemoglobin, fatigue and quality of life in anemic cancer patients: results from five randomized clinical trials. Ann Oncol. 2004, 15: 979-986.View ArticlePubMedGoogle Scholar
- Caro JJ, Salas M, Ward A, Goss G: Anemia as an independent prognostic factor for survival in patients with cancer: a systemic, quantitative review. Cancer. 2001, 91: 2214-2221.View ArticlePubMedGoogle Scholar
- Aapro MS: Anemia management with erythropoiesis-stimulating agents: a risk-benefit update. Oncologist. 2008, 13 (Suppl 3): 1-3.View ArticlePubMedGoogle Scholar
- Ludwig H: Anemia of hematologic malignancies: what are the treatment options?. Semin Oncol. 2002, 29 (Suppl 8): 45-54.View ArticlePubMedGoogle Scholar
- Stramer SL: Current risks of transfusion-transmitted agents: a review. Arch Pat Lab Med. 2007, 131: 702-707.Google Scholar
- Bernard AC, Davenport DL, Chang PK, Vaughan TB, Zwischenberger JB: Intraoperative transfusion of 1 U to 2 U packed red blood cells is associated with increased 30-day mortality, surgical-site infection, pneumonia, and sepsis in general surgery patients. J Am Coll Surg. 2009, 208: 931-937.View ArticlePubMedGoogle Scholar
- Koch CG, Li L, Duncan AI, Mihaljevic T, Loop FD, Starr NJ, Blackstone EH: Transfusion in coronary artery bypass grafting is associated with reduced long-term survival. Ann Thorac Surg. 2006, 81: 1650-1657.View ArticlePubMedGoogle Scholar
- Macdougall IC: Novel erythropoiesis-stimulating agents: a new era in anemia management. Clin J Am Soc Nephrol. 2008, 3: 200-207.View ArticlePubMedGoogle Scholar
- Topf JM: CERA: third-generation erythropoiesis-stimulating agent. Expert Opin Pharmacother. 2008, 9: 839-849.View ArticlePubMedGoogle Scholar
- Wauters I, Vansteenkiste J: Darbepoetin alfa in the treatment of chemotherapy-induced anaemia. Expert Opin Biol Ther. 2009, 9: 221-230.View ArticlePubMedGoogle Scholar
- Bohlius J, Tonia T, Schwarzer G: Twist and shout: one decade of meta-analyses of erythropoiesis-stimulating agents in cancer patients. Acta Haematol. 2011, 125: 55-67.View ArticlePubMedGoogle Scholar
- Bohlius J, Schmidlin K, Brillant C, Schwarzer G, Trelle S, Seidenfeld J, Zwahlen M, Clarke M, Weingart O, Kluge S, Piper M, Rades D, Steensma DP, Djulbegovic B, Fey MF, Ray-Coquard I, Machtay M, Moebus V, Thomas G, Untch M, Schumacher M, Egger M, Engert A: Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: a meta-analysis of randomised trials. Lancet. 2009, 373: 1532-1542.View ArticlePubMedGoogle Scholar
- Brinks V, Hawe A, Basmeleh AH, Joachin-Rodriguez L, Haselberg R, Somsen GW, Jiskoot W, Schellekens H: Quality of original and biosimilar epoetin products. Pharm Res. 2011, 28: 386-393.View ArticlePubMedGoogle Scholar
- European Generic Medicines Association: Biosimilars Handbook. 2011, London: Sage Publications Ltd, 2Google Scholar
- CHMP: Guideline on similar biological medicinal products containing biotechnology-derived proteins as active substance: non-clinical and clinical issues. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500003920.pdf,
- Groopman JE, Itri LM: Chemotherapy-induced anemia in adults: incidence and treatment. J Nat Cancer Inst. 1999, 91: 1616-1634.View ArticlePubMedGoogle Scholar
- Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET, Carbone PP: Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 1982, 5: 649-655.View ArticlePubMedGoogle Scholar
- Aapro M, Cornes P, Sun D, Abraham I: Comparative cost efficiency across the European G5 countries of originators and a biosimilar erythropoiesis-stimulating agent to manage chemotherapy-induced anemia in patients with cancer. Ther Adv Med Oncol. 2012, 4: 95-105.View ArticlePubMedPubMed CentralGoogle Scholar
- Tzekova V, Mihaylov G, Elezovic I, Koytchev R: Therapeutic effects of epoetin zeta in the treatment of chemotherapy-induced anaemia. Curr Med Res Opin. 2009, 25: 1689-1697.View ArticlePubMedGoogle Scholar
- Dammacco F, Castoldi G, Rödjer S: Efficacy of epoetin alfa in the treatment of anaemia of multiple myeloma. Br J Haematol. 2001, 113: 172-179.View ArticlePubMedGoogle Scholar
- Zonder JA: Thrombotic complications of myeloma therapy. Hematology Am Soc Hematol Educ Program. 2006, 348-355.Google Scholar
- Birgegård G, Gascón P, Ludwig H: Evaluation of anaemia in patients with multiple myeloma and lymphoma: findings of the European CANCER ANAEMIA SURVEY. Eur J Haematol. 2006, 77: 378-386.View ArticlePubMedPubMed CentralGoogle Scholar
- Sant M, Allemani C, Tereanu C, De Angelis R, Capocaccia R, Visser O, Marcos-Gragera R, Maynadié M, Simonetti A, Lutz JM, Berrino F: Incidence of hematologic malignancies in Europe by morphologic subtype: results of the HAEMACARE project. Blood. 2010, 116: 3724-3734.View ArticlePubMedGoogle Scholar
- Ferlay J, Autier P, Boniol M, Heanue M, Colombet M, Boyle P: Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol. 2007, 18: 581-592.View ArticlePubMedGoogle Scholar
- Schrijvers D, De Samblanx H, Roila F: Erythropoiesis-stimulating agents in the treatment of anaemia in cancer patients: ESMO Clinical Practice Guidelines for use. Ann Oncol. 2010, 21 (Suppl. 5): v244-v247.View ArticlePubMedGoogle Scholar
- Zelenetz AD, Ahmed I, Braud EL, Cross JD, Davenport-Ennis N, Dickinson BD, Goldberg SE, Gottlieb S, Johnson PE, Lyman GH, Markus R, Matulonis UA, Reinke D, Li EC, DeMartino J, Larsen JK, Hoffman JM: NCCN Biosimilars white paper: regulatory, scientific, and patient safety perspectives. J Natl Compr Canc Netw. 2011, 9 (Suppl. 4): S1-S22.PubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/14/503/prepub
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