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  1. DNAX accessory molecule-1 (DNAM-1) is an activating receptor constitutively expressed by macrophages/dendritic cells and by T lymphocytes and Natural Killer (NK) cells, having an important role in anticancer r...

    Authors: Cinzia Fionda, Maria Pia Abruzzese, Alessandra Zingoni, Alessandra Soriani, Biancamaria Ricci, Rosa Molfetta, Rossella Paolini, Angela Santoni and Marco Cippitelli
    Citation: BMC Cancer 2015 15:17
    Content type: Research article Published on:

  2. SBA is a rare tumour which carries a poor prognosis. Very few data on prognostic factors and treatment outcomes are available. We conducted a retrospective analysis of patients treated for SBA at our institution.

    Authors: Khurum Khan, Clare Peckitt, Francesco Sclafani, David Watkins, Sheela Rao, Naureen Starling, Vikram Jain, Sachin Trivedi, Susannah Stanway, David Cunningham and Ian Chau
    Citation: BMC Cancer 2015 15:15
    Content type: Research article Published on:

  3. Metastatic dissemination can exist before a pathologically and clinically detectable manifestation. The structural heterogeneity of colon cancer (CC) in histological sections with respect to the morphology of ...

    Authors: Caren Jayasinghe, Nektaria Simiantonaki and Charles James Kirkpatrick
    Citation: BMC Cancer 2015 15:14
    Content type: Research article Published on:

  4. The role of serine/threonine kinase 33 (STK33) gene in tumorigenesis is still controversial. This study was aimed to investigate whether STK33 had the effect on hypopharyngeal squamous cell carcinoma (HSCC) an...

    Authors: Lingyan Huang, Chen Chen, Guodong Zhang, Yuanrong Ju, Jianzhong Zhang, Haibo Wang and Jianfeng Li
    Citation: BMC Cancer 2015 15:13
    Content type: Research article Published on:

  7. Anthracycline adjuvant therapy has taken a particular role in the treatment of early stage breast cancer with an associated decrease in rates of both relapse and death. Their success however has been limited b...

    Authors: Alain Mina, Hind Rafei, Maya Khalil, Yasmine Hassoun, Zeina Nasser and Arafat Tfayli
    Citation: BMC Cancer 2015 15:10
    Content type: Research article Published on:

  8. Androgens drive the onset and progression of prostate cancer (PCa) via androgen receptor (AR) signalling. The principal treatment for PCa is androgen deprivation therapy, although the majority of patients even...

    Authors: Jennifer Munkley, Nicholas P Lafferty, Gabriela Kalna, Craig N Robson, Hing Y Leung, Prabhakar Rajan and David J Elliott
    Citation: BMC Cancer 2015 15:9
    Content type: Research article Published on:

  11. c-Met, one of current potential hot targets, has been suggested as a potential tumor marker in the development of esophageal squamous cell carcinoma (ESCC). Our aim was to investigate the expression of c-Met i...

    Authors: Yingying Xu, Zhi Peng, Zhongwu Li, Ming Lu, Jing Gao, Yilin Li, Yanyan Li and Lin Shen
    Citation: BMC Cancer 2015 15:6
    Content type: Research article Published on:

  12. The transcription factor nuclear factor (erythroid-2)–related factor 2 (Nrf2) was originally identified as a critical regulator of intracellular anti-oxidants and of phase II detoxification enzymes through its...

    Authors: Yota Kawasaki, Sumiya Ishigami, Takaaki Arigami, Yoshikazu Uenosono, Shigehiro Yanagita, Yasuto Uchikado, Yoshiaki Kita, Yuka Nishizono, Hiroshi Okumura, Akihiro Nakajo, Yuko Kijima, Kosei Maemura and Shoji Natsugoe
    Citation: BMC Cancer 2015 15:5
    Content type: Research article Published on:

  13. Tumour stromal macrophages differentiate to tumour-associated macrophages (TAMs) with characteristics of immunosuppressive M2-type macrophages, having a central role in promoting tumour vascularisation, cancer...

    Authors: Sofia Sousa, Seppo Auriola, Jukka Mönkkönen and Jorma Määttä
    Citation: BMC Cancer 2015 15:4
    Content type: Research article Published on:

  14. Adult T-cell Leukemia (ATL) is a disease with no known cure. The disease manifests itself as an aggressive proliferation of CD4+ cells with the human T-cell Lymphotropic virus type 1 (HTLV-1). The leukemogenesis ...

    Authors: Steve Harakeh, Rania Azar, Esam Azhar, Ghazi A Damanhouri, Mourad Assidi, Muhammad Abu-Elmagd, Mohammed H Alqahtani, Taha Kumosani, Aleksandra Niedzwiecki, Mathias Rath, Ahmed Al-Hejin, Elie Barbour and Mona Diab-Assaf
    Citation: BMC Cancer 2015 15(Suppl 1):S2
    Content type: Research Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  15. The cancer stem cell (CSC) hypothesis suggests that only a subpopulation of cells within a tumour is responsible for the initiation and progression of neoplasia. The original and best evidence for the existenc...

    Authors: Sara Santos Franco, Hadas Raveh-Amit, Julianna Kobolák, Mohammed H Alqahtani, Ali Mobasheri and András Dinnyes
    Citation: BMC Cancer 2015 15(Suppl 1):S1
    Content type: Review Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  16. Evidence from cachectic cancer patients and animal models of cancer cachexia supports the involvement of Forkhead box O (FoxO) transcription factors in driving cancer-induced skeletal muscle wasting. However, ...

    Authors: Sarah M Judge, Chia-Ling Wu, Adam W Beharry, Brandon M Roberts, Leonardo F Ferreira, Susan C Kandarian and Andrew R Judge
    Citation: BMC Cancer 2014 14:997
    Content type: Research article Published on:

  17. Aberrantly expressed and constitutively active STAT3 signaling plays a pivotal role in initiation and progression of human papillomavirus-induced cervical carcinogenesis. However, the underlying mechanism(s) r...

    Authors: Gauri Shishodia, Gaurav Verma, Yogesh Srivastava, Ravi Mehrotra, Bhudev Chandra Das and Alok Chandra Bharti
    Citation: BMC Cancer 2014 14:996
    Content type: Research article Published on:

  18. The calpains are intracellular cysteine proteases that function in a variety of important cellular functions, including signalling, motility, apoptosis and survival. In breast cancer high calpain-1 and calpain...

    Authors: Jillian Davis, Stewart G Martin, Poulam M Patel, Andrew R Green, Emad A Rakha, Ian O Ellis and Sarah J Storr
    Citation: BMC Cancer 2014 14:995
    Content type: Research article Published on:

  19. It is well established that genetic and epigenetic alterations are common events in prostate cancer, which may lead to aberrant expression of critical genes. The importance of epigenetic mechanisms in prostate...

    Authors: Marjolaine Ngollo, Andre Lebert, Aslihan Dagdemir, Gaelle Judes, Seher Karsli-Ceppioglu, Marine Daures, Jean-Louis Kemeny, Frederique Penault-Llorca, Jean-Paul Boiteux, Yves-Jean Bignon, Laurent Guy and Dominique Bernard-Gallon
    Citation: BMC Cancer 2014 14:994
    Content type: Research article Published on:

  20. Paclitaxel treatment produces dose-limiting peripheral neurotoxicity, which adversely affects treatment and long-term outcomes. In the present study, the contribution of genetic polymorphisms to paclitaxel-ind...

    Authors: Susanna B Park, John B Kwok, Clement T Loy, Michael L Friedlander, Cindy S-Y Lin, Arun V Krishnan, Craig R Lewis and Matthew C Kiernan
    Citation: BMC Cancer 2014 14:993
    Content type: Research article Published on:

  21. Glioblastoma multiforme (GBM) is the most frequent primary malignant brain tumor in adults. Despite multimodal therapies, almost all GBM recur within a narrow margin around the initial resected lesion. Thus, n...

    Authors: Frank A Giordano, Stefanie Brehmer, Yasser Abo-Madyan, Grit Welzel, Elena Sperk, Anke Keller, Frank Schneider, Sven Clausen, Carsten Herskind, Peter Schmiedek and Frederik Wenz
    Citation: BMC Cancer 2014 14:992
    Content type: Study protocol Published on:

  22. In breast cancer patients routine thromboprophylaxis is not recommended but individualized risk assessment is encouraged. The incorporation of hypercoagulability biomarkers could increase the sensitivity of ri...

    Authors: Mourad Chaari, Ines Ayadi, Aurelie Rousseau, Eleftheria Lefkou, Patrick Van Dreden, Fatoumata Sidibe, Hela Ketatni, Vassiliki Galea, Amir Khaterchi, Racem Bouzguenda, Mounir Frikha, Lilia Ghorbal, Jamel Daoud, Choumous Kallel, Martin Quinn, Joseph Gligorov…
    Citation: BMC Cancer 2014 14:991
    Content type: Research article Published on:

  23. There are many molecular differences between estrogen receptor α (ERα)-positive and ER-negative breast cancers. Recent analyses have shown that the former can be divided into two subtypes, luminal A and lumina...

    Authors: Yumi Endo, Hiroko Yamashita, Satoru Takahashi, Shinya Sato, Nobuyasu Yoshimoto, Tomoko Asano, Yukari Hato, Yu Dong, Yoshitaka Fujii and Tatsuya Toyama
    Citation: BMC Cancer 2014 14:990
    Content type: Research article Published on:

  24. Response Evaluation Criteria in Solid Tumors (RECIST) are widely used to assess the effect of chemotherapy in patients with cancer. We hypothesised that the change in unidimensional tumour size handled as a co...

    Authors: Anne-Claire Toffart, Denis Moro-Sibilot, Sébastien Couraud, Patrick Merle, Maurice Perol, Nicolas Girard, Pierre-Jean Souquet, Bénédicte Mastroianni, Gilbert R Ferretti, Philippe Romand, Patrick Chatellain, Aurélien Vesin, Elisabeth Brambilla, Christian Brambilla and Jean-François Timsit
    Citation: BMC Cancer 2014 14:989
    Content type: Research article Published on:

  26. Natural products from plants have been proven to be important resources of antitumor agents. In this study, we exploited the antitumor activity of (E)-3-(4-chlorophenyl)-N-(7-hydroxy-6-methoxy-2-oxo-2H-chromen...

    Authors: Peng Zhao, Li Chen, Lin-Hu Li, Zhi-Feng Wei, Bei Tong, Yu-Gai Jia, Ling-Yi Kong, Yu-Feng Xia and Yue Dai
    Citation: BMC Cancer 2014 14:987
    Content type: Research article Published on:

  27. The purpose of this phase II study was to evaluate the safety and efficacy of weekly irinotecan and capecitabine (wXELIRI) treatment in patients with metastatic colorectal cancer, specifically the rate of seve...

    Authors: Wenhua Li, Jianming Xu, Lin Shen, Tianshu Liu, Weijian Guo, Wen Zhang, Zhiyu Chen, Xiaodong Zhu and Jin Li
    Citation: BMC Cancer 2014 14:986
    Content type: Research article Published on:

  28. Raised serum glucose has been linked to increased risk of many solid cancers. We performed a meta-analysis to quantify and summarise the evidence for this link.

    Authors: Danielle J Crawley, Lars Holmberg, Jennifer C Melvin, Massimo Loda, Simon Chowdhury, Sarah M Rudman and Mieke Van Hemelrijck
    Citation: BMC Cancer 2014 14:985
    Content type: Research article Published on:

  29. To analyze and compare the economic outcomes of adjuvant chemotherapy with capecitabine plus oxaliplatin (referred to as the XELOX strategy) and of S-1 (the S-1 strategy) for gastric cancer patients after D2 g...

    Authors: Bin Wu, Te Li, Jian Cai, Yuejuan Xu and Gang Zhao
    Citation: BMC Cancer 2014 14:984
    Content type: Research article Published on:

  30. BRCA1 and BRCA2 genes are critical in homologous recombination DNA repair and have been implicated in familial breast and ovarian cancer tumorigenesis. Tumour cells with these mutations demonstrate increased s...

    Authors: Shibani Nicum, Corran Roberts, Lucy Boyle, Sylwia Kopijasz, Charlie Gourley, Marcia Hall, Ana Montes, Christopher Poole, Linda Collins, Anna Schuh and Susan J Dutton
    Citation: BMC Cancer 2014 14:983
    Content type: Study protocol Published on:

  31. Ovarian low-grade serous carcinoma (LGSC) has fewer mutations than ovarian high-grade serous carcinoma (HGSC) and a less aggressive clinical course. However, an overwhelming majority of LGSC patients do not re...

    Authors: Alicia A Tone, Melissa K McConechy, Winnie Yang, Jiarui Ding, Stephen Yip, Esther Kong, Kwong-Kwok Wong, David M Gershenson, Helen Mackay, Sohrab Shah, Blake Gilks, Anna V Tinker, Blaise Clarke, Jessica N McAlpine and David Huntsman
    Citation: BMC Cancer 2014 14:982
    Content type: Research article Published on:

  32. Leiomyosarcomas represent the largest subtype of soft tissue sarcomas. Two subgroups can be distinguished, non-uterine (NULMS) and uterine leiomyosarcomas (ULMS). The aim of this retrospective study was to eva...

    Authors: Wolfgang Lamm, Camilla Natter, Sophie Schur, Wolfgang J Köstler, Alexander Reinthaller, Michael Krainer, Christoph Grimm, Reinhard Horvath, Gabriele Amann, Philipp Funovics, Thomas Brodowicz and Stephan Polterauer
    Citation: BMC Cancer 2014 14:981
    Content type: Research article Published on:

  33. Malnutrition is an independent risk factor of postoperative morbidity and mortality and it’s observed in 20 to 50% of surgical patients. Preoperative interventions to optimize the nutritional status, reduce po...

    Authors: Oriana Ciacio, Thibault Voron, Gabriella Pittau, Maité Lewin, Eric Vibert, René Adam, Antonio Sa Cunha, Daniel Cherqui, Astrid Schielke, Olivier Soubrane, Olivier Scatton, Chady Salloum, Daniel Azoulay, Stéphane Benoist, Perrine Goyer, Jean-Christophe Vaillant…
    Citation: BMC Cancer 2014 14:980
    Content type: Study protocol Published on:

  34. Although international comparisons reveal large geographical differences in the incidence of breast and gynaecological cancers, incidence data for ethnic groups in England remains scarce.

    Authors: Megan H Shirley, Isobel Barnes, Shameq Sayeed, Alexander Finlayson and Raghib Ali
    Citation: BMC Cancer 2014 14:979
    Content type: Research article Published on:

  35. SIRT1 is a member of the mammalian sirtuin family with the ability to deacetylate histone and nonhistone proteins. The correlation between SIRT1 expression and tumor metastasis in several types of cancer has a...

    Authors: Chong Hao, Peng-Xi Zhu, Xue Yang, Zhi-Peng Han, Jing-Hua Jiang, Chen Zong, Xu-Guang Zhang, Wen-Ting Liu, Qiu-Dong Zhao, Ting-Ting Fan, Li Zhang and Li-Xin Wei
    Citation: BMC Cancer 2014 14:978
    Content type: Research article Published on:

  36. Although chemotherapy for prostate cancer (PCa) can improve patient survival, some tumours are chemo-resistant. Tumour molecular profiles may help identify the mechanisms of drug action and identify potential ...

    Authors: Prabhakar Rajan, Jacqueline Stockley, Ian M Sudbery, Janis T Fleming, Ann Hedley, Gabriela Kalna, David Sims, Chris P Ponting, Andreas Heger, Craig N Robson, Rhona M McMenemin, Ian D Pedley and Hing Y Leung
    Citation: BMC Cancer 2014 14:977
    Content type: Research article Published on:

  37. The prognostic value of circulating tumor cells (CTCs) in colorectal cancer (CRC) patients and their value in predicting tumor response to chemotherapy are controversial. The aim of this meta-analysis was to a...

    Authors: Xuanzhang Huang, Peng Gao, Yongxi Song, Jingxu Sun, Xiaowan Chen, Junhua Zhao, Jing Liu, Huimian Xu and Zhenning Wang
    Citation: BMC Cancer 2014 14:976
    Content type: Research article Published on:

  39. Members of the urokinase-type plasminogen activator (uPA) system including uPA, its receptor uPAR and the plasminogen activator inhibitor 1 (PAI-1) play an important role in tumour invasion and progression in ...

    Authors: Susanne Fuessel, Kati Erdmann, Helge Taubert, Andrea Lohse-Fischer, Stefan Zastrow, Matthias Meinhardt, Karen Bluemke, Lorenz Hofbauer, Paolo Fornara, Bernd Wullich, Gustavo Baretton, Viktor Magdolen, Manfred P Wirth and Matthias Kotzsch
    Citation: BMC Cancer 2014 14:974
    Content type: Research article Published on:

  40. Head and neck cancer is an important cause of ill health. Survival appears to be improving but the reasons for this are unclear. They could include evolving aetiology, modifications in care, improvements in tr...

    Authors: Andrew Robert Ness, Andrea Waylen, Katrina Hurley, Mona Jeffreys, Chris Penfold, Miranda Pring, Sam Leary, Christine Allmark, Stu Toms, Susan Ring, Tim J Peters, Will Hollingworth, Helen Worthington, Chris Nutting, Sheila Fisher, Simon N Rogers…
    Citation: BMC Cancer 2014 14:973
    Content type: Study protocol Published on:

  41. Numerous attempts have been made to establish and develop tumor markers that could determine the susceptibility of normal tissues to transform into cancerous ones. To determine whether altered expression patte...

    Authors: Sandra Ventorin von Zeidler, Talitha de Souza Botelho, Elismauro Francisco Mendonça and Aline Carvalho Batista
    Citation: BMC Cancer 2014 14:972
    Content type: Research article Published on:

  42. Treatment of cancer in the lung in octogenarians is limited by their health and functional status. Stereotactic ablative radiotherapy is an established noninvasive treatment option for medically inoperable pat...

    Authors: Nathan A Cannon, Puneeth Iyengar, Hak Choy, Robert Timmerman and Jeffrey Meyer
    Citation: BMC Cancer 2014 14:971
    Content type: Research article Published on:

  43. We recently published PROGgene, a tool that can be used to study prognostic implications of genes in various cancers. The first version of the tool had several areas for improvement. In this paper we present s...

    Authors: Chirayu Pankaj Goswami and Harikrishna Nakshatri
    Citation: BMC Cancer 2014 14:970
    Content type: Software Published on:

  44. Tumor debulking surgery followed by adjuvant chemotherapy or radiotherapy is a standard treatment for many solid malignancies. Although this approach can be effective, it often has limited success against recu...

    Authors: Andrea Khong, Amanda L Cleaver, Muhammad Fahmi Alatas, Ben C Wylie, Theresa Connor, Scott A Fisher, Steve Broomfield, Willem J Lesterhuis, Andrew J Currie, Richard A Lake and Bruce W Robinson
    Citation: BMC Cancer 2014 14:969
    Content type: Research article Published on:

  45. Infection with human papillomavirus (HPV) is necessary for the development of cervical carcinoma. By contrast, the role of HPV in the pathogenesis of other malignancies, such as head and neck cancers, is less ...

    Authors: Seye Abogunrin, Gian Luca Di Tanna, Sam Keeping, Stuart Carroll and Ike Iheanacho
    Citation: BMC Cancer 2014 14:968
    Content type: Research article Published on:

  46. Vemurafenib, a selective inhibitor of genetically activated BRAF, is registered for unresectable stage III and stage IV melanomas harboring a BRAF mutation. Photosensitivity related to exposure to sunlight is ...

    Authors: Steve Boudewijns, Winald R Gerritsen and Rutger sH T Koornstra
    Citation: BMC Cancer 2014 14:967
    Content type: Case report Published on:

  47. Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor that acts against receptors for vascular endothelial growth factor and platelet-derived growth factor. Common toxicities of sunitinib treatment ...

    Authors: Yuji Miura, Chiyo K Imamura, Koya Fukunaga, Yoshihiko Katsuyama, Koichi Suyama, Toshikazu Okaneya, Taisei Mushiroda, Yuichi Ando, Toshimi Takano and Yusuke Tanigawara
    Citation: BMC Cancer 2014 14:964
    Content type: Case report Published on:

  48. Mixed phenotype acute leukemias (MPAL) include acute leukemias with blasts that express antigens of more than one lineage, with no clear evidence of myeloid or lymphoid lineage differentiation. T/myeloid (T/My...

    Authors: Giuseppina Tota, Nicoletta Coccaro, Antonella Zagaria, Luisa Anelli, Paola Casieri, Angelo Cellamare, Angela Minervini, Crescenzio Francesco Minervini, Claudia Brunetti, Luciana Impera, Paola Carluccio, Cosimo Cumbo, Giorgina Specchia and Francesco Albano
    Citation: BMC Cancer 2014 14:963
    Content type: Case report Published on:

  49. Uveal melanoma is a tumour arising from melanocytes of the eye, and 30 per cent of these patients develop liver metastases. Exosomes are small RNA containing nano-vesicles released by most cells, including mal...

    Authors: Maria Eldh, Roger Olofsson Bagge, Cecilia Lässer, Joar Svanvik, Margareta Sjöstrand, Jan Mattsson, Per Lindnér, Dong-Sic Choi, Yong Song Gho and Jan Lötvall
    Citation: BMC Cancer 2014 14:962
    Content type: Research article Published on:

  50. This is an international study across four European countries (Belgium[BE], the Netherlands[NL], Italy[IT] and Spain[ES]) between 2009 and 2011, describing and comparing care and care setting transitions provi...

    Authors: Winne Ko, Luc Deliens, Guido Miccinesi, Francesco Giusti, Sarah Moreels, Gé A Donker, Bregje Onwuteaka-Philipsen, Oscar Zurriaga, Aurora López-Maside and Lieve Van den Block
    Citation: BMC Cancer 2014 14:960
    Content type: Research article Published on:

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