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  1. c-Met is widely known as a poor prognostic factor in various human malignancies. Previous studies have suggested the involvement of c-Met and/or its ligand, hepatocyte growth factor (HGF), in esophageal squamo...

    Authors: Yohei Ozawa, Yasuhiro Nakamura, Fumiyoshi Fujishima, Saulo JA Felizola, Kenichiro Takeda, Hiroshi Okamoto, Ken Ito, Hirotaka Ishida, Takuro Konno, Takashi Kamei, Go Miyata, Noriaki Ohuchi and Hironobu Sasano
    Citation: BMC Cancer 2015 15:451
    Content type: Research article Published on:

  2. Pulmonary tumour thrombotic microangiopathy (PTTM) is a rare complication of metastatic cancer with a distinct histological appearance which presents with dyspnoea and pulmonary arterial hypertension and leads...

    Authors: Andrew LK. Ho, Patryk Szulakowsi and Waria HS. Mohamid
    Citation: BMC Cancer 2015 15:450
    Content type: Case report Published on:

    The Erratum to this article has been published in BMC Cancer 2015 15:600

  3. Previous studies have mostly focused on the effects of specific constituents of beverages and foods on the risk of esophageal cancer (EC). An increasing number of studies are now emerging examining the health ...

    Authors: Yawen Chen, Yeqing Tong, Chen Yang, Yong Gan, Huilian Sun, Huashan Bi, Shiyi Cao, Xiaoxv Yin and Zuxun Lu
    Citation: BMC Cancer 2015 15:449
    Content type: Research article Published on:

  4. Although human cancers have heterogeneous combinations of altered oncogenes, some crucial genes are universally dysregulated in most cancers. One such gene, FEAT (faint expression in normal tissues, aberrant over...

    Authors: Hongwei Liang, Zheng Fu, Xueyuan Jiang, Nan Wang, Feng Wang, Xueliang Wang, Suyang Zhang, Yanbo Wang, Xin Yan, Wen-xian Guan, Chen-Yu Zhang, Ke Zen, Yujing Zhang, Xi Chen and Guangxin Zhou
    Citation: BMC Cancer 2015 15:448
    Content type: Research article Published on:

  5. Although lymph node (LN) status and the LN burden determine the outcome of bladder cancer patients treated with cystectomy, compelling arguments have been made for the incorporation of LN density into the curr...

    Authors: Ja Hyeon Ku, Minyong Kang, Hyung Suk Kim, Chang Wook Jeong, Cheol Kwak and Hyeon Hoe Kim
    Citation: BMC Cancer 2015 15:447
    Content type: Research article Published on:

  6. This study aimed to provide an updated analysis of childhood cancer mortality rates and long-term trends to 2013 to describe the current level of deaths and identify changes in recent decades.

    Authors: Limin Yang and Junichiro Fujimoto
    Citation: BMC Cancer 2015 15:446
    Content type: Research article Published on:

  7. Fever is common in malignant tumors. We report an exceptional case of psychogenic fever in a patient with small cell lung cancer. This is the first case report of psychogenic fever in a patient with small cell...

    Authors: Mengdan Xu, Xiaoye Zhang, Zhaoguo Xu, Guoyuan Cui, Li Yu, Xiaoying Qi, Jia Lin and Yan Liu
    Citation: BMC Cancer 2015 15:445
    Content type: Case report Published on:

  8. The mechanisms allowing residual multiple myeloma (MM) cells to persist after bortezomib (Bz) treatment remain unclear. We hypothesized that studying the biology of bortezomib-surviving cells may reveal marker...

    Authors: Alfred Adomako, Veronica Calvo, Noa Biran, Keren Osman, Ajai Chari, James C Paton, Adrienne W Paton, Kateri Moore, Denis M Schewe and Julio A Aguirre-Ghiso
    Citation: BMC Cancer 2015 15:444
    Content type: Research article Published on:

  9. International medical organizations such as the American Society of Medical Oncology recommend early palliative care as the “gold standard” for palliative care in patients with advanced cancer. Nevertheless, e...

    Authors: Cornelia Meffert, Jan Gaertner, Katharina Seibel, Karin Jors, Hubert Bardenheuer, Dieter Buchheidt, Regine Mayer-Steinacker, Marén Viehrig, Christina Paul, Stephanie Stock, Carola Xander and Gerhild Becker
    Citation: BMC Cancer 2015 15:443
    Content type: Study protocol Published on:

  11. The chemokine CXCL16 and its receptor CXCR6 are expressed by a variety of immune cells and have been shown to influence angiogenesis. The expression of CXCR6 and CXCL16 has been examined in numerous human canc...

    Authors: Sigurd M. Hald, Yury Kiselev, Samer Al-Saad, Elin Richardsen, Charles Johannessen, Marte Eilertsen, Thomas K. Kilvaer, Khalid Al-Shibli, Sigve Andersen, Lill-Tove Busund, Roy M. Bremnes and Tom Donnem
    Citation: BMC Cancer 2015 15:441
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2016 16:916

  12. To sustain cell growth, cancer cells exhibit an altered metabolism characterized by increased lipogenesis. Stearoyl-CoA desaturase-1 (SCD-1) catalyzes the production of monounsaturated fatty acids that are ess...

    Authors: Anissa Belkaid, Sabrina R. Duguay, Rodney J. Ouellette and Marc E. Surette
    Citation: BMC Cancer 2015 15:440
    Content type: Research article Published on:

  13. Gastric cancer (GC) is one of the major malignant diseases worldwide, especially in Asia, and Japan and Korea have the highest incidence in the world. Because most of the cases that are refractory to therapies...

    Authors: Norihisa Saeki, Rie Komatsuzaki, Fumiko Chiwaki, Kazuyoshi Yanagihara and Hiroki Sasaki
    Citation: BMC Cancer 2015 15:439
    Content type: Research article Published on:

  15. Recent studies have indicated the possible function of miR-217 in tumorigenesis. However, the roles of miR-217 in colorectal cancer (CRC) are still largely unknown.

    Authors: Bo Wang, Zhan-long Shen, Ke-wei Jiang, Gang Zhao, Chun-you Wang, Yi-chao Yan, Yang Yang, Ji-zhun Zhang, Chao Shen, Zhi-dong Gao, Ying-jiang Ye and Shan Wang
    Citation: BMC Cancer 2015 15:437
    Content type: Research article Published on:

  16. Overexpression or mutation of the epidermal growth factor receptor (EGFR) potently enhances the growth of many solid tumors. Tumor cells frequently display resistance to mechanistically-distinct EGFR-directed ...

    Authors: Ursula D. Ramirez, Anna S. Nikonova, Hanqing Liu, Anna Pecherskaya, Sarah H. Lawrence, Ilya G. Serebriiskii, Yan Zhou, Matthew K. Robinson, Margret B. Einarson, Erica A. Golemis and Eileen K. Jaffe
    Citation: BMC Cancer 2015 15:436
    Content type: Research article Published on:

  18. The study of genetic variants alone is not enough to explain a complex disease like cancer. Alterations in DNA methylation patterns have been associated with different types of tumor. In order to detect marker...

    Authors: Mónica Cappetta, María Berdasco, Jimena Hochmann, Carolina Bonilla, Mónica Sans, Pedro C Hidalgo, Nora Artagaveytia, Rick Kittles, Miguel Martínez, Manel Esteller and Bernardo Bertoni
    Citation: BMC Cancer 2015 15:434
    Content type: Research article Published on:

  19. Interleukin-27 (IL-27) has been recognized as a pleiotropic cytokine with both pro- and anti-inflammatory properties. Few studies have investigated polymorphisms and serum/plasma levels of IL-27 in diseases in...

    Authors: Bin Zhou, Peng Zhang, Tielong Tang, Hong Liao, Kui Zhang, Yan Pu, Peng Chen, Yaping Song and Lin Zhang
    Citation: BMC Cancer 2015 15:433
    Content type: Research article Published on:

  20. Despite adequate trans-urethral resection of the bladder tumour (TURBT), non-muscle-invasive bladder cancer (NMIBC) is associated with high rates of recurrence and progression. Instillation of Bacillus Calmett...

    Authors: Dickon Hayne, Martin Stockler, Steve P. McCombie, Venu Chalasani, Anne Long, Andrew Martin, Shomik Sengupta and Ian D. Davis
    Citation: BMC Cancer 2015 15:432
    Content type: Study protocol Published on:

  21. Hepsin, (also called TMPRSS1) and TMPRSS3 are type II transmembrane serine proteases (TTSPs) that are involved in cancer progression. TTSPs can remodel extracellular matrix (ECM) and, when dysregulated, promot...

    Authors: Mikko Pelkonen, Kaisa Luostari, Maria Tengström, Hermanni Ahonen, Bozena Berdel, Vesa Kataja, Ylermi Soini, Veli-Matti Kosma and Arto Mannermaa
    Citation: BMC Cancer 2015 15:431
    Content type: Research article Published on:

  22. Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of decitabine (DAC) in the European Union (EU) in 2012 for the treatment of patients with AML ...

    Authors: Olga Grishina, Claudia Schmoor, Konstanze Döhner, Björn Hackanson, Beate Lubrich, Annette M. May, Caroline Cieslik, Michael J. Müller and Michael Lübbert
    Citation: BMC Cancer 2015 15:430
    Content type: Study protocol Published on:

  23. Leucopenia or neutropenia during chemotherapy predicts better survival in several cancers. We aimed to assess whether leucopenia could be a biological measure of treatment and a marker of efficacy in advanced ...

    Authors: Zhen Su, Yan-Ping Mao, Pu-Yun OuYang, Jie Tang, Xiao-Wen Lan and Fang-Yun Xie
    Citation: BMC Cancer 2015 15:429
    Content type: Research article Published on:

  24. The peritoneum is the second most common site of recurrence in colorectal cancer. Early detection of peritoneal carcinomatosis (PC) by imaging is difficult. Patients eventually presenting with clinically appar...

    Authors: Charlotte E L Klaver, Gijsbert D Musters, Willem A Bemelman, Cornelis J A Punt, Victor J Verwaal, Marcel GW Dijkgraaf, Arend GJ Aalbers, Jarmila DW van der Bilt, Djamila Boerma, Andre JA Bremers, Jacobus WA Burger, Christianne J Buskens, Pauline Evers, Robert J van Ginkel, Wilhelmina MU van Grevenstein, Patrick HJ Hemmer…
    Citation: BMC Cancer 2015 15:428
    Content type: Study protocol Published on:

  25. Proper functional association between mural cells and endothelial cells (EC) causes EC of blood vessels to become quiescent. Mural cells on tumor vessels exhibit decreased attachment to EC, which allows vessel...

    Authors: Mayur Choudhary, Christine Naczki, Wenhong Chen, Keith D. Barlow, L. Douglas Case and Linda J. Metheny-Barlow
    Citation: BMC Cancer 2015 15:427
    Content type: Research article Published on:

  26. Metastatic renal cell carcinoma (mRCC) had been a chemo-refractory disease, but recent advances in multiple kinase inhibitors such as sunitinib have dramatically changed the clinical course of mRCC. Sunitinib ...

    Authors: Kotoe Takayoshi, Kosuke Sagara, Keita Uchino, Hitoshi Kusaba, Naotaka Sakamoto, Atsushi Iguchi and Eishi Baba
    Citation: BMC Cancer 2015 15:426
    Content type: Case report Published on:

  27. Iron binding, naturally occurring protein bovine lactoferrin (bLf) has attracted attention as a safe anti-cancer agent capable of inducing apoptosis. Naturally, bLf exists partially saturated (15-20%) with Fe3+ h...

    Authors: Jessica A. Gibbons, Jagat R. Kanwar and Rupinder K. Kanwar
    Citation: BMC Cancer 2015 15:425
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2018 18:749

  28. We recently developed a clinical decision support tool, capable of estimating the likelihood of survival at 3 and 12 months following surgery for patients with operable skeletal metastases. After making it pub...

    Authors: Andrea Piccioli, M. Silvia Spinelli, Jonathan A. Forsberg, Rikard Wedin, John H. Healey, Vincenzo Ippolito, Primo Andrea Daolio, Pietro Ruggieri, Giulio Maccauro, Alessandro Gasbarrini, Roberto Biagini, Raimondo Piana, Flavio Fazioli, Alessandro Luzzati, Alberto Di Martino, Francesco Nicolosi…
    Citation: BMC Cancer 2015 15:424
    Content type: Research article Published on:

  29. Anthracycline and taxane are classes of drugs that are frequently used in the adjuvant and palliative settings of metastatic breast cancer (MBC); however, treatment failure occurs in most cases. Limited data d...

    Authors: Kun-Ming Rau, Yung-Chang Lin, Yen-Yang Chen, Jen-Shi Chen, Kuan-Der Lee, Cheng-Hsu Wang and Hsien-Kun Chang
    Citation: BMC Cancer 2015 15:423
    Content type: Research article Published on:

  30. The hypoxia-activated prodrug TH-302 is reduced at its nitroimidazole group and selectively under hypoxic conditions releases the DNA cross-linker bromo-isophosphoramide mustard (Br-IPM). Here, we have explore...

    Authors: Fanying Meng, Deepthi Bhupathi, Jessica D Sun, Qian Liu, Dharmendra Ahluwalia, Yan Wang, Mark D Matteucci and Charles P Hart
    Citation: BMC Cancer 2015 15:422
    Content type: Research article Published on:

  31. A Danish cancer pathway has been implemented for patients with serious non-specific symptoms and signs of cancer (NSSC-CPP). The initiative is one of several to improve the long diagnostic interval and the poo...

    Authors: Mads Lind Ingeman, Morten Bondo Christensen, Flemming Bro, Søren T. Knudsen and Peter Vedsted
    Citation: BMC Cancer 2015 15:421
    Content type: Research article Published on:

  32. Primary androgen deprivation therapy (PADT) has played an important role in the treatment of prostate cancer. We sought to identify factors of PSA progression in our series of patients with localized and local...

    Authors: Atsushi Tomioka, Nobumichi Tanaka, Motokiyo Yoshikawa, Makito Miyake, Satoshi Anai, Yoshitomo Chihara, Eijiro Okajima, Akihide Hirayama, Yoshihiko Hirao and Kiyohide Fujimoto
    Citation: BMC Cancer 2015 15:420
    Content type: Research article Published on:

  33. Colorectal cancer is the third most common cancer and a major cause of morbidity and mortality worldwide. Adjuvant chemotherapy is considered the standard of care in patients with UICC stage III colon cancer a...

    Authors: Andreas Teufel, Michael Gerken, Janine Hartl, Timo Itzel, Stefan Fichtner-Feigl, Christian Stroszczynski, Hans Jürgen Schlitt, Ferdinand Hofstädter and Monika Klinkhammer-Schalke
    Citation: BMC Cancer 2015 15:419
    Content type: Research article Published on:

  34. Non-attendance at gynecological clinics is a major limitation of cervical cancer screening and self-collection of samples may improve this situation. Although HPV testing of self-collected vaginal samples is a...

    Authors: Cheng-Chang Chang, Rui-Lan Huang, Yu-Ping Liao, Po-Hsuan Su, Yaw-Wen Hsu, Hui-Chen Wang, Chau-Yang Tien, Mu-Hsien Yu, Ya-Wen Lin and Hung-Cheng Lai
    Citation: BMC Cancer 2015 15:418
    Content type: Research article Published on:

  35. DNA methylation regulates gene expression, through the inhibition/activation of gene transcription of methylated/unmethylated genes. Hence, DNA methylation profiling can capture pivotal features of gene expres...

    Authors: Yan Li, Anatoliy A. Melnikov, Victor Levenson, Emanuela Guerra, Pasquale Simeone, Saverio Alberti and Youping Deng
    Citation: BMC Cancer 2015 15:417
    Content type: Research article Published on:

  36. Pain is a prevalent and distressing symptom in patients with cancer, having an enormous impact on functioning and quality of life. Fragmentation of care, inadequate pain communication, and reluctance towards p...

    Authors: Laura MJ Hochstenbach, Annemie M Courtens, Sandra MG Zwakhalen, Maarten van Kleef and Luc P de Witte
    Citation: BMC Cancer 2015 15:416
    Content type: Study protocol Published on:

  37. Mucinous ovarian tumors represent a distinct histotype of epithelial ovarian cancer. The rarest (2-4 % of ovarian carcinomas) of the five major histotypes, their genomic landscape remains poorly described. We ...

    Authors: Robertson Mackenzie, Stefan Kommoss, Boris J. Winterhoff, Benjamin R. Kipp, Joaquin J. Garcia, Jesse Voss, Kevin Halling, Anthony Karnezis, Janine Senz, Winnie Yang, Elena-Sophie Prigge, Miriam Reuschenbach, Magnus Von Knebel Doeberitz, Blake C. Gilks, David G. Huntsman, Jamie Bakkum-Gamez…
    Citation: BMC Cancer 2015 15:415
    Content type: Research article Published on:

  38. Preliminary evidence suggests cancer- and chemotherapy-related autonomic nervous system (ANS) dysfunction may contribute to the increased cardiovascular (CV) morbidity- and mortality-risks in cancer survivors....

    Authors: Scott C. Adams, Ronald Schondorf, Julie Benoit and Robert D. Kilgour
    Citation: BMC Cancer 2015 15:414
    Content type: Research article Published on:

  39. Translational biomedical research relies on the availability of human tissue to explore disease aetiology and prognostic factors, with the objective of developing better targeted treatments. The establishment ...

    Authors: Jamie Bryant, Rob Sanson-Fisher, Elizabeth Fradgley, Timothy Regan, Breanne Hobden and Stephen P. Ackland
    Citation: BMC Cancer 2015 15:413
    Content type: Research article Published on:

  40. To demonstrate how assessment of life expectancy and loss in expectation of life can be used to address a wide range of research questions of public health interest pertaining to the prognosis of cancer patients.

    Authors: Therese M-L Andersson, Paul W. Dickman, Sandra Eloranta, Annika Sjövall, Mats Lambe and Paul C. Lambert
    Citation: BMC Cancer 2015 15:412
    Content type: Research article Published on:

  41. Colorectal cancer (CRC) is a leading cause of cancer death globally and new biomarkers and treatments are severely needed.

    Authors: Elena Pedraz-Cuesta, Sandra Christensen, Anders A. Jensen, Niels Frank Jensen, Lennart Bunch, Maria Unni Romer, Nils Brünner, Jan Stenvang and Stine Falsig Pedersen
    Citation: BMC Cancer 2015 15:411
    Content type: Research article Published on:

  42. An alternative approach to the traditional model of radiologists interpreting screening mammography is necessary due to the shortage of radiologists to interpret screening mammograms in many countries.

    Authors: Gabriela Torres-Mejía, Robert A. Smith, María de la Luz Carranza-Flores, Andy Bogart, Louis Martínez-Matsushita, Diana L. Miglioretti, Karla Kerlikowske, Carolina Ortega-Olvera, Ernesto Montemayor-Varela, Angélica Angeles-Llerenas, Sergio Bautista-Arredondo, Gilberto Sánchez-González, Olga G. Martínez-Montañez, Santos R. Uscanga-Sánchez, Eduardo Lazcano-Ponce and Mauricio Hernández-Ávila
    Citation: BMC Cancer 2015 15:410
    Content type: Research article Published on:

  43. The lack of prognostic biomarkers in oral squamous cell carcinoma (OSCC) has hampered treatment decision making and survival in OSCC remains poor. Histopathological features are used for prognostication in OSC...

    Authors: Pinaki Bose, Nigel T Brockton, Kelly Guggisberg, Steven C Nakoneshny, Elizabeth Kornaga, Alexander C Klimowicz, Mauro Tambasco and Joseph C Dort
    Citation: BMC Cancer 2015 15:409
    Content type: Research article Published on:

  44. Most of the blood tests aiming for breast cancer screening rely on quantification of a single or few biomarkers. The aim of this study was to evaluate the feasibility of detecting breast cancer by analyzing th...

    Authors: Udi Zelig, Eyal Barlev, Omri Bar, Itai Gross, Felix Flomen, Shaul Mordechai, Joseph Kapelushnik, Ilana Nathan, Hanoch Kashtan, Nir Wasserberg and Osnat Madhala-Givon
    Citation: BMC Cancer 2015 15:408
    Content type: Research article Published on:

  45. The objective of this work was to demonstrate that autoantibodies in breast cancer sera are not epiphenomena, and exhibit unique immunologic features resembling the rheumatic autoimmune diseases.

    Authors: Félix Fernández Madrid, Marie-Claire Maroun, Ofelia A Olivero, Michael Long, Azadeh Stark, Lawrence I Grossman, Walter Binder, Jingsheng Dong, Matthew Burke, S David Nathanson, Richard Zarbo, Dhananjay Chitale, Rocío Zeballos-Chávez and Carol Peebles
    Citation: BMC Cancer 2015 15:407
    Content type: Research article Published on:

  46. To analyze the clinical application of endoscope with narrow-band imaging (NBI) system in detecting high-grade dysplasia, carcinoma in situ, and carcinoma in oral erythroplakia.

    Authors: Shih-Wei Yang, Yun-Shien Lee, Liang-Che Chang, Cheng-Cheng Hwang, Cheng-Ming Luo and Tai-An Chen
    Citation: BMC Cancer 2015 15:406
    Content type: Research article Published on:

  47. Breast cancer is the leading cause of cancer deaths in women world-wide. In low and middle income countries, where there are no population-based mammographic screening programmes, late presentation is common, ...

    Authors: Yew-Ching Teh, Gie-Hooi Tan, Nur Aishah Taib, Kartini Rahmat, Caroline Judy Westerhout, Farhana Fadzli, Mee-Hoong See, Suniza Jamaris and Cheng-Har Yip
    Citation: BMC Cancer 2015 15:405
    Content type: Research article Published on:

  48. Cancer-specific survival has changed remarkably little over the past half century, mainly because metastases that are occult at diagnosis and generally resistant to chemotherapy subsequently develop months, ye...

    Authors: Robert E. Hurst, Paul J. Hauser, Youngjae You, Lora C. Bailey-Downs, Anja Bastian, Stephen M. Matthews, Jessica Thorpe, Christine Earle, Lilly Y. W. Bourguignon and Michael A. Ihnat
    Citation: BMC Cancer 2015 15:404
    Content type: Research article Published on:

  49. In metastatic breast cancer (MBC), antigen profiles of metastatic tissue and primary tumor differ in up to 20 % of patients. Reassessment of predictive markers, including human epidermal growth factor receptor...

    Authors: Markus Wallwiener, Andreas Daniel Hartkopf, Sabine Riethdorf, Juliane Nees, Martin Ronald Sprick, Birgitt Schönfisch, Florin-Andrei Taran, Jörg Heil, Christof Sohn, Klaus Pantel, Andreas Trumpp and Andreas Schneeweiss
    Citation: BMC Cancer 2015 15:403
    Content type: Research article Published on:

  50. Leptomeningeal metastasis of melanoma is a devastating complication with a grave prognosis, and there are no known effective standard treatments. Although selective BRAF inhibitors have demonstrated a signific...

    Authors: Dae Won Kim, Edelyn Barcena, Urvi N Mehta, Michelle L Rohlfs, Ashok J Kumar, Marta Penas-Prado and Kevin B Kim
    Citation: BMC Cancer 2015 15:400
    Content type: Case report Published on:

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