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  1. To compare the overall survival of patients with hepatocellular carcinoma (HCC) who were treated with lipiodol-based conventional transarterial chemoembolization (cTACE) with that of patients treated with drug...

    Authors: Roman Kloeckner, Arndt Weinmann, Friederike Prinz, Daniel Pinto dos Santos, Christian Ruckes, Christoph Dueber and Michael Bernhard Pitton
    Citation: BMC Cancer 2015 15:465
    Content type: Research article Published on:

  2. Improvement of transduction and augmentation of cytotoxicity are crucial for adenoviruses (Ad)-mediated gene therapy for cancer. Down-regulated expression of type 5 Ad (Ad5) receptors on human tumors hampered ...

    Authors: Shan Yang, Kiyoko Kawamura, Shinya Okamoto, Suguru Yamauchi, Masato Shingyoji, Ikuo Sekine, Hiroshi Kobayashi, Yuji Tada, Koichiro Tatsumi, Kenzo Hiroshima, Hideaki Shimada and Masatoshi Tagawa
    Citation: BMC Cancer 2015 15:464
    Content type: Research article Published on:

  3. Caveolin-1 (CAV1) has been implicated both in tumor suppression and progression, whereby the specific role appears to be context dependent. Endometrial cancer is one of the most common malignancies of the fema...

    Authors: Natalia Diaz-Valdivia, Denisse Bravo, Hernán Huerta, Soledad Henriquez, Fernando Gabler, Margarita Vega, Carmen Romero, Claudia Calderon, Gareth I. Owen, Lisette Leyton and Andrew F. G. Quest
    Citation: BMC Cancer 2015 15:463
    Content type: Research article Published on:

  4. Overexpression of transketolase-like 1 protein TKTL1 in cancer cells has been reported to correlate with enhanced glycolysis and lactic acid production. Furthermore, enhanced TKTL1 expression was put into cont...

    Authors: Ulrike Kämmerer, Olivier Gires, Nadja Pfetzer, Armin Wiegering, Rainer Johannes Klement and Christoph Otto
    Citation: BMC Cancer 2015 15:2
    Content type: Research article Published on:

  6. The metabolic effect of intratumor cholesteryl ester (CE) in breast cancer remains poorly understood. The objective was to analyze the relationship between intratumor CE content and clinicopathological variabl...

    Authors: David de Gonzalo-Calvo, Laura López-Vilaró, Laura Nasarre, Maitane Perez-Olabarria, Tania Vázquez, Daniel Escuin, Lina Badimon, Agusti Barnadas, Enrique Lerma and Vicenta Llorente-Cortés
    Citation: BMC Cancer 2015 15:460
    Content type: Research article Published on:

  7. Cholangiocarcinoma (CCA) is an extremely aggressive cancer that is usually fatal. Although globally morbidity and mortality are increasing, knowledge of the disease remains limited. The Mekong region of Southe...

    Authors: Narong Khuntikeo, Nittaya Chamadol, Puangrat Yongvanit, Watcharin Loilome, Nisana Namwat, Paiboon Sithithaworn, Ross H. Andrews, Trevor N. Petney, Supannee Promthet, Kavin Thinkhamrop, Chaiwat Tawarungruang and Bandit Thinkhamrop
    Citation: BMC Cancer 2015 15:459
    Content type: Study protocol Published on:

  8. Circulating tumor cell (CTCs) counts might serve as early surrogate marker for treatment efficacy in metastatic castration-resistant prostate cancer (mCRPC) patients. We prospectively assessed categorical and ...

    Authors: Mark Thalgott, Brigitte Rack, Matthias Eiber, Michael Souvatzoglou, Matthias M. Heck, Caroline Kronester, Ulrich Andergassen, Victoria Kehl, Bernd J. Krause, Jurgen E. Gschwend, Margitta Retz and Roman Nawroth
    Citation: BMC Cancer 2015 15:458
    Content type: Research article Published on:

  9. The Adenomatous Polyposis Coli (APC) tumor suppressor is mutated or hypermethylated in up to 70 % of sporadic breast cancers depending on subtype; however, the effects of APC mutation on tumorigenic properties re...

    Authors: Monica K. VanKlompenberg, Claire O. Bedalov, Katia Fernandez Soto and Jenifer R. Prosperi
    Citation: BMC Cancer 2015 15:457
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2016 16:921

  10. The interactions established between macrophages and cancer cells are largely dependent on instructions from the tumour microenvironment. Macrophages may differentiate into populations with distinct inflammato...

    Authors: Ana P. Cardoso, Marta L. Pinto, Ana T. Pinto, Marta T. Pinto, Cátia Monteiro, Marta I. Oliveira, Susana G. Santos, João B. Relvas, Raquel Seruca, Alberto Mantovani, Marc Mareel, Mário A. Barbosa and Maria J. Oliveira
    Citation: BMC Cancer 2015 15:456
    Content type: Research article Published on:

  11. Vinflunine is recommended in the European guideline for the treatment of advanced or metastatic urothelial cell carcinoma (UCC) after failure of platinum-based therapy.

    Authors: Margitta Retz, Patrick de Geeter, Peter J. Goebell, Ullrich Matz, Wito de Schultz and Axel Hegele
    Citation: BMC Cancer 2015 15:455
    Content type: Research article Published on:

  12. MAPK7/ERK5 (extracellular-signal-regulated kinase 5) functions within a canonical three-tiered MAPK (mitogen activated protein kinase) signaling cascade comprising MEK (MAPK/ERK kinase) 5, MEKK(MEK kinase) 2/3...

    Authors: Paul R. Gavine, Mei Wang, Dehua Yu, Eva Hu, Chunlei Huang, Jenny Xia, Xinying Su, Joan Fan, Tianwei Zhang, Qingqing Ye, Li Zheng, Guanshan Zhu, Ziliang Qian, Qingquan Luo, Ying Yong Hou and Qunsheng Ji
    Citation: BMC Cancer 2015 15:454
    Content type: Research article Published on:

  13. The Transforming growth factor β (TGFβ) signaling has a paradoxical role in cancer development and outcome. Besides, the prognostic significance of the TGFβ1, SMAD4 in breast cancer patients is an area of many...

    Authors: Loay Kassem, Mathieu Deygas, Laurent Fattet, Jonathan Lopez, Thibaut Goulvent, Emilie Lavergne, Sylvie Chabaud, Nicolas Carrabin, Nicolas Chopin, Thomas Bachelot, Germain Gillet, Isabelle Treilleux and Ruth Rimokh
    Citation: BMC Cancer 2015 15:453
    Content type: Research article Published on:

  14. Postoperative adjuvant chemotherapy for patients with stage III Colorectal cancer (CRC) is now internationally accepted as standard care for improving patient outcomes. The Adjuvant Chemotherapy Trial of S-1 f...

    Authors: Chu Matsuda, Mamoru Uemura, Ken Nakata, Tatsushi Shingai, Junichi Nishimura, Taishi Hata, Masakazu Ikenaga, Ichiro Takemasa, Tsunekazu Mizushima, Takeshi Kato, Masataka Ikeda, Masayuki Ohue, Kohei Murata, Junichi Hasegawa, Taroh Satoh, Hirofumi Yamamoto…
    Citation: BMC Cancer 2015 15:452
    Content type: Study protocol Published on:

  15. c-Met is widely known as a poor prognostic factor in various human malignancies. Previous studies have suggested the involvement of c-Met and/or its ligand, hepatocyte growth factor (HGF), in esophageal squamo...

    Authors: Yohei Ozawa, Yasuhiro Nakamura, Fumiyoshi Fujishima, Saulo JA Felizola, Kenichiro Takeda, Hiroshi Okamoto, Ken Ito, Hirotaka Ishida, Takuro Konno, Takashi Kamei, Go Miyata, Noriaki Ohuchi and Hironobu Sasano
    Citation: BMC Cancer 2015 15:451
    Content type: Research article Published on:

  16. Pulmonary tumour thrombotic microangiopathy (PTTM) is a rare complication of metastatic cancer with a distinct histological appearance which presents with dyspnoea and pulmonary arterial hypertension and leads...

    Authors: Andrew LK. Ho, Patryk Szulakowsi and Waria HS. Mohamid
    Citation: BMC Cancer 2015 15:450
    Content type: Case report Published on:

    The Erratum to this article has been published in BMC Cancer 2015 15:600

  17. Previous studies have mostly focused on the effects of specific constituents of beverages and foods on the risk of esophageal cancer (EC). An increasing number of studies are now emerging examining the health ...

    Authors: Yawen Chen, Yeqing Tong, Chen Yang, Yong Gan, Huilian Sun, Huashan Bi, Shiyi Cao, Xiaoxv Yin and Zuxun Lu
    Citation: BMC Cancer 2015 15:449
    Content type: Research article Published on:

  18. Although human cancers have heterogeneous combinations of altered oncogenes, some crucial genes are universally dysregulated in most cancers. One such gene, FEAT (faint expression in normal tissues, aberrant over...

    Authors: Hongwei Liang, Zheng Fu, Xueyuan Jiang, Nan Wang, Feng Wang, Xueliang Wang, Suyang Zhang, Yanbo Wang, Xin Yan, Wen-xian Guan, Chen-Yu Zhang, Ke Zen, Yujing Zhang, Xi Chen and Guangxin Zhou
    Citation: BMC Cancer 2015 15:448
    Content type: Research article Published on:

  19. Although lymph node (LN) status and the LN burden determine the outcome of bladder cancer patients treated with cystectomy, compelling arguments have been made for the incorporation of LN density into the curr...

    Authors: Ja Hyeon Ku, Minyong Kang, Hyung Suk Kim, Chang Wook Jeong, Cheol Kwak and Hyeon Hoe Kim
    Citation: BMC Cancer 2015 15:447
    Content type: Research article Published on:

  20. This study aimed to provide an updated analysis of childhood cancer mortality rates and long-term trends to 2013 to describe the current level of deaths and identify changes in recent decades.

    Authors: Limin Yang and Junichiro Fujimoto
    Citation: BMC Cancer 2015 15:446
    Content type: Research article Published on:

  21. Fever is common in malignant tumors. We report an exceptional case of psychogenic fever in a patient with small cell lung cancer. This is the first case report of psychogenic fever in a patient with small cell...

    Authors: Mengdan Xu, Xiaoye Zhang, Zhaoguo Xu, Guoyuan Cui, Li Yu, Xiaoying Qi, Jia Lin and Yan Liu
    Citation: BMC Cancer 2015 15:445
    Content type: Case report Published on:

  22. The mechanisms allowing residual multiple myeloma (MM) cells to persist after bortezomib (Bz) treatment remain unclear. We hypothesized that studying the biology of bortezomib-surviving cells may reveal marker...

    Authors: Alfred Adomako, Veronica Calvo, Noa Biran, Keren Osman, Ajai Chari, James C Paton, Adrienne W Paton, Kateri Moore, Denis M Schewe and Julio A Aguirre-Ghiso
    Citation: BMC Cancer 2015 15:444
    Content type: Research article Published on:

  23. International medical organizations such as the American Society of Medical Oncology recommend early palliative care as the “gold standard” for palliative care in patients with advanced cancer. Nevertheless, e...

    Authors: Cornelia Meffert, Jan Gaertner, Katharina Seibel, Karin Jors, Hubert Bardenheuer, Dieter Buchheidt, Regine Mayer-Steinacker, Marén Viehrig, Christina Paul, Stephanie Stock, Carola Xander and Gerhild Becker
    Citation: BMC Cancer 2015 15:443
    Content type: Study protocol Published on:

  25. The chemokine CXCL16 and its receptor CXCR6 are expressed by a variety of immune cells and have been shown to influence angiogenesis. The expression of CXCR6 and CXCL16 has been examined in numerous human canc...

    Authors: Sigurd M. Hald, Yury Kiselev, Samer Al-Saad, Elin Richardsen, Charles Johannessen, Marte Eilertsen, Thomas K. Kilvaer, Khalid Al-Shibli, Sigve Andersen, Lill-Tove Busund, Roy M. Bremnes and Tom Donnem
    Citation: BMC Cancer 2015 15:441
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2016 16:916

  26. To sustain cell growth, cancer cells exhibit an altered metabolism characterized by increased lipogenesis. Stearoyl-CoA desaturase-1 (SCD-1) catalyzes the production of monounsaturated fatty acids that are ess...

    Authors: Anissa Belkaid, Sabrina R. Duguay, Rodney J. Ouellette and Marc E. Surette
    Citation: BMC Cancer 2015 15:440
    Content type: Research article Published on:

  27. Gastric cancer (GC) is one of the major malignant diseases worldwide, especially in Asia, and Japan and Korea have the highest incidence in the world. Because most of the cases that are refractory to therapies...

    Authors: Norihisa Saeki, Rie Komatsuzaki, Fumiko Chiwaki, Kazuyoshi Yanagihara and Hiroki Sasaki
    Citation: BMC Cancer 2015 15:439
    Content type: Research article Published on:

  29. Recent studies have indicated the possible function of miR-217 in tumorigenesis. However, the roles of miR-217 in colorectal cancer (CRC) are still largely unknown.

    Authors: Bo Wang, Zhan-long Shen, Ke-wei Jiang, Gang Zhao, Chun-you Wang, Yi-chao Yan, Yang Yang, Ji-zhun Zhang, Chao Shen, Zhi-dong Gao, Ying-jiang Ye and Shan Wang
    Citation: BMC Cancer 2015 15:437
    Content type: Research article Published on:

  30. Overexpression or mutation of the epidermal growth factor receptor (EGFR) potently enhances the growth of many solid tumors. Tumor cells frequently display resistance to mechanistically-distinct EGFR-directed ...

    Authors: Ursula D. Ramirez, Anna S. Nikonova, Hanqing Liu, Anna Pecherskaya, Sarah H. Lawrence, Ilya G. Serebriiskii, Yan Zhou, Matthew K. Robinson, Margret B. Einarson, Erica A. Golemis and Eileen K. Jaffe
    Citation: BMC Cancer 2015 15:436
    Content type: Research article Published on:

  32. The study of genetic variants alone is not enough to explain a complex disease like cancer. Alterations in DNA methylation patterns have been associated with different types of tumor. In order to detect marker...

    Authors: Mónica Cappetta, María Berdasco, Jimena Hochmann, Carolina Bonilla, Mónica Sans, Pedro C Hidalgo, Nora Artagaveytia, Rick Kittles, Miguel Martínez, Manel Esteller and Bernardo Bertoni
    Citation: BMC Cancer 2015 15:434
    Content type: Research article Published on:

  33. Interleukin-27 (IL-27) has been recognized as a pleiotropic cytokine with both pro- and anti-inflammatory properties. Few studies have investigated polymorphisms and serum/plasma levels of IL-27 in diseases in...

    Authors: Bin Zhou, Peng Zhang, Tielong Tang, Hong Liao, Kui Zhang, Yan Pu, Peng Chen, Yaping Song and Lin Zhang
    Citation: BMC Cancer 2015 15:433
    Content type: Research article Published on:

  34. Despite adequate trans-urethral resection of the bladder tumour (TURBT), non-muscle-invasive bladder cancer (NMIBC) is associated with high rates of recurrence and progression. Instillation of Bacillus Calmett...

    Authors: Dickon Hayne, Martin Stockler, Steve P. McCombie, Venu Chalasani, Anne Long, Andrew Martin, Shomik Sengupta and Ian D. Davis
    Citation: BMC Cancer 2015 15:432
    Content type: Study protocol Published on:

  35. Hepsin, (also called TMPRSS1) and TMPRSS3 are type II transmembrane serine proteases (TTSPs) that are involved in cancer progression. TTSPs can remodel extracellular matrix (ECM) and, when dysregulated, promot...

    Authors: Mikko Pelkonen, Kaisa Luostari, Maria Tengström, Hermanni Ahonen, Bozena Berdel, Vesa Kataja, Ylermi Soini, Veli-Matti Kosma and Arto Mannermaa
    Citation: BMC Cancer 2015 15:431
    Content type: Research article Published on:

  36. Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of decitabine (DAC) in the European Union (EU) in 2012 for the treatment of patients with AML ...

    Authors: Olga Grishina, Claudia Schmoor, Konstanze Döhner, Björn Hackanson, Beate Lubrich, Annette M. May, Caroline Cieslik, Michael J. Müller and Michael Lübbert
    Citation: BMC Cancer 2015 15:430
    Content type: Study protocol Published on:

  37. Leucopenia or neutropenia during chemotherapy predicts better survival in several cancers. We aimed to assess whether leucopenia could be a biological measure of treatment and a marker of efficacy in advanced ...

    Authors: Zhen Su, Yan-Ping Mao, Pu-Yun OuYang, Jie Tang, Xiao-Wen Lan and Fang-Yun Xie
    Citation: BMC Cancer 2015 15:429
    Content type: Research article Published on:

  38. The peritoneum is the second most common site of recurrence in colorectal cancer. Early detection of peritoneal carcinomatosis (PC) by imaging is difficult. Patients eventually presenting with clinically appar...

    Authors: Charlotte E L Klaver, Gijsbert D Musters, Willem A Bemelman, Cornelis J A Punt, Victor J Verwaal, Marcel GW Dijkgraaf, Arend GJ Aalbers, Jarmila DW van der Bilt, Djamila Boerma, Andre JA Bremers, Jacobus WA Burger, Christianne J Buskens, Pauline Evers, Robert J van Ginkel, Wilhelmina MU van Grevenstein, Patrick HJ Hemmer…
    Citation: BMC Cancer 2015 15:428
    Content type: Study protocol Published on:

  39. Proper functional association between mural cells and endothelial cells (EC) causes EC of blood vessels to become quiescent. Mural cells on tumor vessels exhibit decreased attachment to EC, which allows vessel...

    Authors: Mayur Choudhary, Christine Naczki, Wenhong Chen, Keith D. Barlow, L. Douglas Case and Linda J. Metheny-Barlow
    Citation: BMC Cancer 2015 15:427
    Content type: Research article Published on:

  40. Metastatic renal cell carcinoma (mRCC) had been a chemo-refractory disease, but recent advances in multiple kinase inhibitors such as sunitinib have dramatically changed the clinical course of mRCC. Sunitinib ...

    Authors: Kotoe Takayoshi, Kosuke Sagara, Keita Uchino, Hitoshi Kusaba, Naotaka Sakamoto, Atsushi Iguchi and Eishi Baba
    Citation: BMC Cancer 2015 15:426
    Content type: Case report Published on:

  41. Iron binding, naturally occurring protein bovine lactoferrin (bLf) has attracted attention as a safe anti-cancer agent capable of inducing apoptosis. Naturally, bLf exists partially saturated (15-20%) with Fe3+ h...

    Authors: Jessica A. Gibbons, Jagat R. Kanwar and Rupinder K. Kanwar
    Citation: BMC Cancer 2015 15:425
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2018 18:749

  42. We recently developed a clinical decision support tool, capable of estimating the likelihood of survival at 3 and 12 months following surgery for patients with operable skeletal metastases. After making it pub...

    Authors: Andrea Piccioli, M. Silvia Spinelli, Jonathan A. Forsberg, Rikard Wedin, John H. Healey, Vincenzo Ippolito, Primo Andrea Daolio, Pietro Ruggieri, Giulio Maccauro, Alessandro Gasbarrini, Roberto Biagini, Raimondo Piana, Flavio Fazioli, Alessandro Luzzati, Alberto Di Martino, Francesco Nicolosi…
    Citation: BMC Cancer 2015 15:424
    Content type: Research article Published on:

  43. Anthracycline and taxane are classes of drugs that are frequently used in the adjuvant and palliative settings of metastatic breast cancer (MBC); however, treatment failure occurs in most cases. Limited data d...

    Authors: Kun-Ming Rau, Yung-Chang Lin, Yen-Yang Chen, Jen-Shi Chen, Kuan-Der Lee, Cheng-Hsu Wang and Hsien-Kun Chang
    Citation: BMC Cancer 2015 15:423
    Content type: Research article Published on:

  44. The hypoxia-activated prodrug TH-302 is reduced at its nitroimidazole group and selectively under hypoxic conditions releases the DNA cross-linker bromo-isophosphoramide mustard (Br-IPM). Here, we have explore...

    Authors: Fanying Meng, Deepthi Bhupathi, Jessica D Sun, Qian Liu, Dharmendra Ahluwalia, Yan Wang, Mark D Matteucci and Charles P Hart
    Citation: BMC Cancer 2015 15:422
    Content type: Research article Published on:

  45. A Danish cancer pathway has been implemented for patients with serious non-specific symptoms and signs of cancer (NSSC-CPP). The initiative is one of several to improve the long diagnostic interval and the poo...

    Authors: Mads Lind Ingeman, Morten Bondo Christensen, Flemming Bro, Søren T. Knudsen and Peter Vedsted
    Citation: BMC Cancer 2015 15:421
    Content type: Research article Published on:

  46. Primary androgen deprivation therapy (PADT) has played an important role in the treatment of prostate cancer. We sought to identify factors of PSA progression in our series of patients with localized and local...

    Authors: Atsushi Tomioka, Nobumichi Tanaka, Motokiyo Yoshikawa, Makito Miyake, Satoshi Anai, Yoshitomo Chihara, Eijiro Okajima, Akihide Hirayama, Yoshihiko Hirao and Kiyohide Fujimoto
    Citation: BMC Cancer 2015 15:420
    Content type: Research article Published on:

  47. Colorectal cancer is the third most common cancer and a major cause of morbidity and mortality worldwide. Adjuvant chemotherapy is considered the standard of care in patients with UICC stage III colon cancer a...

    Authors: Andreas Teufel, Michael Gerken, Janine Hartl, Timo Itzel, Stefan Fichtner-Feigl, Christian Stroszczynski, Hans Jürgen Schlitt, Ferdinand Hofstädter and Monika Klinkhammer-Schalke
    Citation: BMC Cancer 2015 15:419
    Content type: Research article Published on:

  48. DNA methylation regulates gene expression, through the inhibition/activation of gene transcription of methylated/unmethylated genes. Hence, DNA methylation profiling can capture pivotal features of gene expres...

    Authors: Yan Li, Anatoliy A. Melnikov, Victor Levenson, Emanuela Guerra, Pasquale Simeone, Saverio Alberti and Youping Deng
    Citation: BMC Cancer 2015 15:417
    Content type: Research article Published on:

  49. Pain is a prevalent and distressing symptom in patients with cancer, having an enormous impact on functioning and quality of life. Fragmentation of care, inadequate pain communication, and reluctance towards p...

    Authors: Laura MJ Hochstenbach, Annemie M Courtens, Sandra MG Zwakhalen, Maarten van Kleef and Luc P de Witte
    Citation: BMC Cancer 2015 15:416
    Content type: Study protocol Published on:

  50. Mucinous ovarian tumors represent a distinct histotype of epithelial ovarian cancer. The rarest (2-4 % of ovarian carcinomas) of the five major histotypes, their genomic landscape remains poorly described. We ...

    Authors: Robertson Mackenzie, Stefan Kommoss, Boris J. Winterhoff, Benjamin R. Kipp, Joaquin J. Garcia, Jesse Voss, Kevin Halling, Anthony Karnezis, Janine Senz, Winnie Yang, Elena-Sophie Prigge, Miriam Reuschenbach, Magnus Von Knebel Doeberitz, Blake C. Gilks, David G. Huntsman, Jamie Bakkum-Gamez…
    Citation: BMC Cancer 2015 15:415
    Content type: Research article Published on:

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