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  1. Platinum based therapy is commonly used in the treatment of advanced gastric cancer. However, resistance to chemotherapy is a major challenge that causes marked variation in individual response rate and surviv...

    Authors: Vinod Vijay Subhash, Shi Hui Tan, Woei Loon Tan, Mei Shi Yeo, Chen Xie, Foong Ying Wong, Zee Ying Kiat, Robert Lim and Wei Peng Yong
    Citation: BMC Cancer 2015 15:550
    Content type: Research article Published on:

  2. Non-small cell lung cancer (NSCLC) frequently presents in advanced stages. A significant proportion of those with reportedly good ECOG performance status (PS) fail to receive planned multidisciplinary team (MD...

    Authors: Jemima T. Collins, Simon Noble, John Chester, Helen E. Davies, William D. Evans, Jason Lester, Diane Parry, Rebecca J. Pettit and Anthony Byrne
    Citation: BMC Cancer 2015 15:544
    Content type: Study protocol Published on:

  3. Locally advanced rectal cancer (LARC) comprises heterogeneous tumours with predominant hypoxic components. The hypoxia-inducible metabolic shift causes microenvironmental acidification generated by carbonic an...

    Authors: Helga Helseth Hektoen, Kjersti Flatmark, Yvonne Andersson, Svein Dueland, Kathrine Røe Redalen and Anne Hansen Ree
    Citation: BMC Cancer 2015 15:543
    Content type: Research article Published on:

  4. Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths, reflecting the aggressiveness of this type of cancer and the absence of effective therapeutic regimens. MicroRNAs have been ...

    Authors: Alexandra Drakaki, Maria Hatziapostolou, Christos Polytarchou, Christina Vorvis, George A. Poultsides, John Souglakos, Vassilis Georgoulias and Dimitrios Iliopoulos
    Citation: BMC Cancer 2015 15:542
    Content type: Research article Published on:

  5. HIV infection is associated with a higher incidence of precancerous cervical lesions and their progression to invasive cervical cancer (ICC). Zambia is a global epicenter of HIV and ICC, yet the overall burden...

    Authors: Allen C. Bateman, Katundu Katundu, Mulindi H. Mwanahamuntu, Sharon Kapambwe, Vikrant V. Sahasrabuddhe, Michael L. Hicks, Benjamin H. Chi, Jeffrey S. A. Stringer, Groesbeck P. Parham and Carla J. Chibwesha
    Citation: BMC Cancer 2015 15:541
    Content type: Research article Published on:

  6. For breast cancer patients diagnosed with estrogen receptor (ER)-positive tumors, treatment with tamoxifen is the gold standard. A significant number of patients, however, develop resistance to tamoxifen, and ...

    Authors: Aamir Ahmad, Kevin R. Ginnebaugh, Shuping Yin, Aliccia Bollig-Fischer, Kaladhar B. Reddy and Fazlul H. Sarkar
    Citation: BMC Cancer 2015 15:540
    Content type: Research article Published on:

  7. Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. While the multi-step model of pediatric leukemogenesis suggests interplay between constitutional and somatic genomes, the role of inherit...

    Authors: Jean-François Spinella, Jasmine Healy, Virginie Saillour, Chantal Richer, Pauline Cassart, Manon Ouimet and Daniel Sinnett
    Citation: BMC Cancer 2015 15:539
    Content type: Research article Published on:

  8. Posttranscriptional protein modification by SUMOylation plays an important role in tumor development and progression. In the current study we analyzed prevalence and prognostic impact of the de-SUMOylation enz...

    Authors: Christoph Burdelski, Devi Menan, Maria Christina Tsourlakis, Martina Kluth, Claudia Hube-Magg, Nathaniel Melling, Sarah Minner, Christina Koop, Markus Graefen, Hans Heinzer, Corinna Wittmer, Guido Sauter, Ronald Simon, Thorsten Schlomm, Stefan Steurer and Till Krech
    Citation: BMC Cancer 2015 15:538
    Content type: Research article Published on:

  10. Class III β-tubulin, Sox2, and Survivin play important roles in tumor survival and proliferation. However, the association of these three factors with clinicopathological characteristics, chemoresistance, and ...

    Authors: Jintong Du, Bei Li, Yingli Fang, Yanguo Liu, Yang Wang, Jisheng Li, Wen Zhou and Xiuwen Wang
    Citation: BMC Cancer 2015 15:536
    Content type: Research article Published on:

  11. Renal toxicity has been reported with bisphosphonates such as pamidronate and zolidronate but not with ibandronate, in the treatment of breast cancer patients with bone metastasis. One of the patterns of bisph...

    Authors: Ning Jia, Fionnuala C. Cormack, Bin Xie, Zita Shiue, Behzad Najafian and Julie R. Gralow
    Citation: BMC Cancer 2015 15:535
    Content type: Case report Published on:

  12. Clinical studies implying the sunitinib multi-kinase inhibitor have led to disappointing results for breast cancer care but mostly focused on HER2-negative subtypes. Preclinical researches involving this drug ...

    Authors: Benoît Thézé, Nicholas Bernards, Audrey Beynel, Stephan Bouet, Bertrand Kuhnast, Irène Buvat, Bertrand Tavitian and Raphaël Boisgard
    Citation: BMC Cancer 2015 15:534
    Content type: Research article Published on:

  13. Circulating tumor cells (CTCs) play a crucial role in tumor dissemination and are an independent survival predictor in breast cancer (BC) patients. Epithelial to mesenchymal transition (EMT) is involved in can...

    Authors: M. Mego, Z. Cierna, P. Janega, M. Karaba, G. Minarik, J. Benca, T. Sedlácková, G. Sieberova, P. Gronesova, D. Manasova, D. Pindak, J. Sufliarsky, L. Danihel, JM Reuben and J. Mardiak
    Citation: BMC Cancer 2015 15:533
    Content type: Research article Published on:

  14. The optimal management of patients with resectable gastric cancer continues to evolve in Western countries. Following publication of the US Intergroup 0116 and UK Medical Research Council MAGIC trials, there a...

    Authors: Trevor Leong, B Mark Smithers, Michael Michael, Val Gebski, Alex Boussioutas, Danielle Miller, John Simes, John Zalcberg, Karin Haustermans, Florian Lordick, Christoph Schuhmacher, Carol Swallow, Gail Darling and Rebecca Wong
    Citation: BMC Cancer 2015 15:532
    Content type: Study protocol Published on:

  15. Nuclear factor E2-related factor 2 (Nrf2 or NFE2L2) is abundantly expressed in cancer cells and relates to proliferation, invasion, and chemoresistance. Our early observations also found that expression of Nrf...

    Authors: Mingxin Zhang, Chao Zhang, Lingmin Zhang, Qi Yang, Suna Zhou, Qinsheng Wen and Jingjie Wang
    Citation: BMC Cancer 2015 15:531
    Content type: Research article Published on:

  16. The aim of this study was to determine whether early tumor shrinkage (ETS) at 6 weeks after treatment correlates with progression-free survival (PFS) and overall survival (OS) in advanced biliary tract cancer ...

    Authors: Seung Tae Kim, Kee-Taek Jang, Su Jin Lee, Hye-Lim Jang, Jeeyun Lee, Se Hoon Park, Young Suk Park, Ho Yeong Lim, Won Ki Kang and Joon Oh Park
    Citation: BMC Cancer 2015 15:530
    Content type: Research article Published on:

  17. Increasing evidence indicates that rapamycin could be used as a potential glucocorticoid (GC) sensitizer in lymphoblastic malignancies via genetic prevention of 4E-BP1 phosphorylation. Interestingly, we found ...

    Authors: Ling Gu, Liping Xie, Chuan Zuo, Zhigui Ma, Yanle Zhang, Yiping Zhu and Ju Gao
    Citation: BMC Cancer 2015 15:529
    Content type: Research article Published on:

  18. Because to date there is no available study on STAT3 polymorphism and gastric cancer in Western populations and taking into account that Helicobacter pylori CagA EPIYA-C segment deregulates SHP-2/ERK-JAK/STAT3 pa...

    Authors: Gifone A Rocha, Andreia MC Rocha, Adriana D Gomes, César LL Faria Jr, Fabrício F Melo, Sérgio A Batista, Viviane C Fernandes, Nathálie BF Almeida, Kádima N Teixeira, Kátia S Brito and Dulciene Maria Magalhães Queiroz
    Citation: BMC Cancer 2015 15:528
    Content type: Research article Published on:

  19. Tumor lymphangiogenesis plays an important role in promoting growth and metastasis of tumors, but no antilymphangiogenic agent is used clinically. Based on the effect of norcantharidin (NCTD) on lymphangiogene...

    Authors: Xin-Ping Li, Wei Jing, Jian-Jun Sun, Zhong-Yan Liu, Jing-Tao Zhang, Wei Sun, Wei Zhu and Yue-Zu Fan
    Citation: BMC Cancer 2015 15:527
    Content type: Research article Published on:

  20. There is a clear link between irregular breathing and errors in medical imaging and radiation treatment. The audiovisual biofeedback system is an advanced form of respiratory guidance that has previously demon...

    Authors: Sean Pollock, Ricky O’Brien, Kuldeep Makhija, Fiona Hegi-Johnson, Jane Ludbrook, Angela Rezo, Regina Tse, Thomas Eade, Roland Yeghiaian-Alvandi, Val Gebski and Paul J Keall
    Citation: BMC Cancer 2015 15:526
    Content type: Study protocol Published on:

  21. The lymph node metastasis is a key early step of the tumor metastatic process. VEGFD-mediated tumor lymphangiogenesis plays a key role, since down-regulation of p-VEGFR-3 could block the lymph node metastasis....

    Authors: Youzhi Xu, Wenjie Lu, Peng Yang, Wen Peng, Chunting Wang, Manli Li, Yan Li, Guobo Li, Nana Meng, Hongjun Lin, Lixin Kan, Siying Wang, Shengyong Yang, Luoting Yu and YingLan Zhao
    Citation: BMC Cancer 2015 15:525
    Content type: Research article Published on:

  22. Alternate transcripts from a single gene locus greatly enhance the combinatorial flexibility of the human transcriptome. Different patterns of exon usage have been observed when comparing normal tissue to canc...

    Authors: Sunniva Stordal Bjørklund, Vessela N. Kristensen, Michael Seiler, Surendra Kumar, Grethe I. Grenaker Alnæs, Yao Ming, John Kerrigan, Bjørn Naume, Ravi Sachidanandam, Gyan Bhanot, Anne-Lise Børresen-Dale and Shridar Ganesan
    Citation: BMC Cancer 2015 15:524
    Content type: Research article Published on:

  23. About 3885 women are diagnosed with breast cancer and 1285 die from the disease each year in Bulgaria. However no genetic testing to identify the mutations in high-risk families has been provided so far.

    Authors: Rumyana Ivanova Dodova, Atanaska Velichkova Mitkova, Daniela Rosenova Dacheva, Lina Basam Hadjo, Alexandrina Ivanova Vlahova, Margarita Stoyanova Taushanova - Hadjieva, Spartak Stoyanov Valev, Marija Mitko Caulevska, Stanislava Dimitrova Popova, Ivan Emilov Popov, Tihomir Iliichev Dikov, Theophil Angelov Sedloev, Atanas Stefanov Ionkov, Konstanta Velinova Timcheva, Svetlana Liubomirova Christova, Ivo Marinov Kremensky…
    Citation: BMC Cancer 2015 15:523
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2017 17:195

  24. High grade gliomas (HGGs; grades III and IV) are the most common primary brain tumors in adults, and their malignant nature ranks them fourth in incidence of cancer death. Standard treatment for glioblastomas ...

    Authors: Rheal A. Towner, Michael Ihnat, Debra Saunders, Anja Bastian, Nataliya Smith, Roheeth Kumar Pavana and Aleem Gangjee
    Citation: BMC Cancer 2015 15:522
    Content type: Research article Published on:

  25. The preoperative prognostic nutritional index (PNI) has been reported to correlate with the prognosis in patents with various carcinomas. However, the prognostic significance of the postoperative PNI is unknow...

    Authors: Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Yasuhito Iseki, Tetsuro Ikeya, Kenji Sugano and Kosei Hirakawa
    Citation: BMC Cancer 2015 15:521
    Content type: Research article Published on:

  26. Despite the large number of published papers analyzing the prognostic role of Ki-67 in NSCLC, it is still not considered an established factor for routine use in clinical practice. The present meta-analysis su...

    Authors: Song Wen, Wei Zhou, Chun-ming Li, Juan Hu, Xiao-ming Hu, Ping Chen, Guo-liang Shao and Wu-hua Guo
    Citation: BMC Cancer 2015 15:520
    Content type: Research article Published on:

  27. Aim of this prospective study was to predict response to neoadjuvant therapy in breast cancer patients using an in vitro breast cancer spheroid model.

    Authors: Kathrin Halfter, Nina Ditsch, Hans-Christian Kolberg, Holger Fischer, Tanja Hauzenberger, Franz Edler von Koch, Ingo Bauerfeind, Gunter von Minckwitz, Ilona Funke, Alexander Crispin and Barbara Mayer
    Citation: BMC Cancer 2015 15:519
    Content type: Research article Published on:

  28. VHL inactivation is the most established molecular characteristic of clear cell renal cell carcinoma (ccRCC), with only a few additional genes implicated in development of this kidney tumor. In recently published...

    Authors: Tomasz Wrzesiński, Malgorzata Szelag, Wojciech A. Cieślikowski, Agnieszka Ida, Rachel Giles, Elżbieta Zodro, Joanna Szumska, Joanna Poźniak, Zbigniew Kwias, Hans A.R. Bluyssen and Joanna Wesoly
    Citation: BMC Cancer 2015 15:518
    Content type: Research article Published on:

  29. Liver metastases from breast cancer (LMBC) are typically considered to indicate systemic disease spread and patients are most often offered systemic palliative treatment only. However, retrospective studies su...

    Authors: Max Seidensticker, Benjamin Garlipp, Sophia Scholz, Konrad Mohnike, Felix Popp, Ingo Steffen, Ricarda Seidensticker, Patrick Stübs, Maciej Pech, Maciej PowerskI, Peter Hass, Serban-Dan Costa, Holger Amthauer, Christiane Bruns and Jens Ricke
    Citation: BMC Cancer 2015 15:517
    Content type: Research article Published on:

  31. Decisions on head and neck squamous cell carcinoma (HNSCC) treatment are widely recognized as being difficult, due to high morbidity, often involving vital functions. Some patients may therefore decline standa...

    Authors: Emilie A. C. Dronkers, Steven W. Mes, Marjan H. Wieringa, Marc P. van der Schroeff and Robert J. Baatenburg de Jong
    Citation: BMC Cancer 2015 15:515
    Content type: Research article Published on:

  32. Determining the driving factors and molecular flow-through that define the switch from favorable to aggressive high-risk disease is critical to the betterment of neuroblastoma cure.

    Authors: Faizan H. Khan, Vijayabaskar Pandian, Satishkumar Ramraj, Mohan Natarajan, Sheeja Aravindan, Terence S. Herman and Natarajan Aravindan
    Citation: BMC Cancer 2015 15:514
    Content type: Research article Published on:

  33. Activating mutations in RAS are present in the majority of pancreatic cancer cases and represent an ideal therapeutic target. Reolysin is a proprietary formulation of oncolytic reovirus that is currently being...

    Authors: Devalingam Mahalingam, Sukeshi Patel, Gerard Nuovo, George Gill, Giovanni Selvaggi, Matt Coffey and Steffan T. Nawrocki
    Citation: BMC Cancer 2015 15:513
    Content type: Case report Published on:

  34. Bone is the most common site of breast cancer distant metastasis, affecting 50–70 % of patients who develop metastatic disease. Despite decades of informative research, the effective prevention, prediction and...

    Authors: Nigel T. Brockton, Stephanie J. Gill, Stephanie L. Laborge, Alexander H. G. Paterson, Linda S. Cook, Hans J. Vogel, Carrie S. Shemanko, David A. Hanley, Anthony M. Magliocco and Christine M. Friedenreich
    Citation: BMC Cancer 2015 15:512
    Content type: Study protocol Published on:

  35. In patients with high risk stage II and stage III colon cancer (CC), curative surgery followed by adjuvant FOLFOX-4 chemotherapy has become the standard of care. However, for 20 to 30 % of these patients, the ...

    Authors: Mehdi Karoui, Anne Rullier, Alain Luciani, Franck Bonnetain, Marie-Luce Auriault, Antony Sarran, Geneviève Monges, Hervé Trillaud, Karine Le Malicot, Karen Leroy, Iradj Sobhani, Armelle Bardier, Marie Moreau, Isabelle Brindel, Jean François Seitz and Julien Taieb
    Citation: BMC Cancer 2015 15:511
    Content type: Study protocol Published on:

  36. We aimed to evaluate the efficiency and safety of cis/carboplatin plus gemcitabine, which was previously used for mesothelioma but with no recorded proof of its efficiency, compared with cis/carboplatin plus p...

    Authors: Guntulu Ak, Selma Metintas, Muhittin Akarsu and Muzaffer Metintas
    Citation: BMC Cancer 2015 15:510
    Content type: Research article Published on:

  37. Drug resistance is still one of the key causes of death in epithelial ovarian carcinoma (EOC) patients, however there are very few strategies to reverse chemoresistance. Here we try to clarify whether and how ...

    Authors: Xiao Li, Qianqian Pan, Xiaoyun Wan, Yuyan Mao, Weiguo Lu, Xing Xie and Xiaodong Cheng
    Citation: BMC Cancer 2015 15:509
    Content type: Research article Published on:

  38. Lenalidomide has been approved for the treatment of lower-risk myelodysplastic syndrome (MDS) with 5q deletion (del(5q)). We present for the first time a retrospective analysis of low-risk MDS with isolated de...

    Authors: Aleksandra Butrym, Ewa Lech-Maranda, Elżbieta Patkowska, Beata Kumiega, Maria Bieniaszewska, Andrzej Mital, Krzysztof Madry, Tigran Torosian, Ryszard Wichary, Justyna Rybka, Krzysztof Warzocha and Grzegorz Mazur
    Citation: BMC Cancer 2015 15:508
    Content type: Research article Published on:

  39. Acrokeratosis paraneoplastica is a rare paraneoplastic phenomenon associated with upper aerodigestive tract carcinomas, usually manifesting as psoriasiform keratosis over the acral sites. It is primarily seen ...

    Authors: Aline Hempen, Eleftherios P Samartzis, Jivko Kamarachev, Daniel Fink and Konstantin J Dedes
    Citation: BMC Cancer 2015 15:507
    Content type: Case report Published on:

  40. While a number of studies have examined miRNA profiles across the molecular subtypes of breast cancer, it is unclear whether BRCA1 basal-like cancers have a specific miRNA profile. This study aims to compare g...

    Authors: Max Yan, Kristy Shield-Artin, David Byrne, Siddhartha Deb, Nic Waddell, Izhak Haviv and Stephen B Fox
    Citation: BMC Cancer 2015 15:506
    Content type: Research article Published on:

  41. Little is known about colorectal adenoma patients’ ability to adhere to behavioural interventions promoting a change in diet and physical activity. This review aimed to examine health behaviour intervention pr...

    Authors: Deborah McCahon, Amanda J. Daley, Janet Jones, Richard Haslop, Arjun Shajpal, Aliki Taylor, Sue Wilson and George Dowswell
    Citation: BMC Cancer 2015 15:505
    Content type: Research article Published on:

  42. Photodynamic therapy (PDT) contains a photosensitizing process, which includes cellular uptake of photosensitizer and delivery of light to the target. ATP-binding cassette subfamily G2 (ABCG2) regulates endoge...

    Authors: Ju Hee Kim, Jae Myung Park, Yoon Jin Roh, In-Wook Kim, Tayyaba Hasan and Myung-Gyu Choi
    Citation: BMC Cancer 2015 15:504
    Content type: Research article Published on:

  43. Communication skills training has proven to be an effective means to enhance communication of health care professionals in oncology. These effects are well studied in standardized settings. The question of tra...

    Authors: Marcelo Niglio de Figueiredo, Bärbel Rodolph, Carma L Bylund, Tanja Goelz, Pia Heußner, Heribert Sattel, Kurt Fritzsche and Alexander Wuensch
    Citation: BMC Cancer 2015 15:503
    Content type: Study protocol Published on:

    The Erratum to this article has been published in BMC Cancer 2015 15:596

  44. Aldehyde dehydrogenase 1 (ALDH1) is widely used as a specific cancer stem cell marker in a variety of cancers, and may become a promising target for cancer therapy. However, the role of its expression in tumor...

    Authors: Ruixia Huang, Xiaoran Li, Ruth Holm, Claes G. Trope, Jahn M. Nesland and Zhenhe Suo
    Citation: BMC Cancer 2015 15:502
    Content type: Research article Published on:

  45. Performance status (PS) assessment is an integral part of the decision-making process in cancer care. Karnofsky Performance Status (KPS) and Eastern Cooperative Oncology Group (ECOG) PS are the most widely use...

    Authors: Carlos Eduardo Paiva, Felipe Augusto Ferreira Siquelli, Henrique Amorim Santos, Marina Moreira Costa, Daniella Ramone Massaro, Domício Carvalho Lacerda, João Soares Nunes, Cristiano de Pádua Souza and Bianca Sakamoto Ribeiro Paiva
    Citation: BMC Cancer 2015 15:501
    Content type: Research article Published on:

  46. Survival from cancer is worse in England than in some European countries. To improve survival, strategies in England have focused on early presentation (reducing delay to improve stage at diagnosis), improving...

    Authors: Rebecca Maclean, Mona Jeffreys, Alex Ives, Tim Jones, Julia Verne and Yoav Ben-Shlomo
    Citation: BMC Cancer 2015 15:500
    Content type: Research article Published on:

  47. MicroRNAs (miRNAs) show differential expression across breast cancer subtypes and have both oncogenic and tumor-suppressive roles. Numerous microarray studies reported different expression patterns of miRNAs i...

    Authors: Geraldine Cizeron-Clairac, François Lallemand, Sophie Vacher, Rosette Lidereau, Ivan Bieche and Celine Callens
    Citation: BMC Cancer 2015 15:499
    Content type: Research article Published on:

  48. Tumor-induced lymphangiogenesis plays a crucial role in metastasis and tumor progression. However, the significance of intratumoral lymphovascular density (I-LVD) and peritumoral lymphovascular density (P-LVD)...

    Authors: Kyung Ho Pak, Ara Jo, Hye Ji Choi, Younghee Choi, Hyunki Kim and Jae-Ho Cheong
    Citation: BMC Cancer 2015 15:498
    Content type: Research article Published on:

  49. BRAF mutations are present in 40 % of human skin melanomas. Mutated tumors with an increased percentage of BRAF mutant alleles (BRAF-M%) may have a better response to RAF/MEK inhibitors. We evaluated the BRAF-M% ...

    Authors: Zofia Hélias-Rodzewicz, Elisa Funck-Brentano, Laure Baudoux, Chan Kwon Jung, Ute Zimmermann, Cristi Marin, Thierry Clerici, Catherine Le Gall, Frédérique Peschaud, Valérie Taly, Philippe Saiag and Jean-François Emile
    Citation: BMC Cancer 2015 15:497
    Content type: Research article Published on:

  50. The management of unresectable metastatic colorectal cancer (mCRC) is a comprehensive treatment strategy involving several lines of therapy, maintenance, salvage surgery, and treatment-free intervals. Besides ...

    Authors: Benoist Chibaudel, Franck Bonnetain, Christophe Tournigand, Marine Hug de Larauze, Armand de Gramont, Pierre Laurent-Puig, Jérôme Paget, Alexandra Hadengue, Dominique Notelet, Magdalena Benetkiewicz, Thierry André and Aimery de Gramont
    Citation: BMC Cancer 2015 15:496
    Content type: Study protocol Published on:

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