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  1. Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in NAD+ biosynthesis from nicotinamide, is one of the major factors regulating cancer cells metabolism and is considered a promising target...

    Authors: Chiara Zucal, Vito G. D’Agostino, Antonio Casini, Barbara Mantelli, Natthakan Thongon, Debora Soncini, Irene Caffa, Michele Cea, Alberto Ballestrero, Alessandro Quattrone, Stefano Indraccolo, Alessio Nencioni and Alessandro Provenzani
    Citation: BMC Cancer 2015 15:855
    Content type: Research article Published on:

  2. The objective of this study is to explore the off-label use of targeted therapies (TTs) for patients with osteosarcoma registered within the French Sarcoma Group – Bone Tumor Study Group (GSF-GETO) national re...

    Authors: Mathilde Penel-Page, Isabelle Ray-Coquard, Julie Larcade, Magali Girodet, Laure Bouclier, Muriel Rogasik, Nadège Corradini, Natacha Entz-Werle, Laurence Brugieres, Julien Domont, Cyril Lervat, Sophie Piperno-Neumann, Helène Pacquement, Jacques-Olivier Bay, Jean-Claude Gentet, Antoine Thyss…
    Citation: BMC Cancer 2015 15:854
    Content type: Research article Published on:

  3. The aim of this study was to develop a scoring system for prediction of survival prognosis after surgery in patients with symptomatic metastatic spinal cord compression (MSCC) from non-small cell lung cancer (...

    Authors: Mingxing Lei, Yaosheng Liu, Chuanghao Tang, Shaoxing Yang, Shubin Liu and Shiguo Zhou
    Citation: BMC Cancer 2015 15:853
    Content type: Research article Published on:

  4. Type 2 diabetes mellitus (T2DM) has been suggested to increase the risk of cancers. The aim of this study was to investigate the risk of common cancers in Chinese patients with T2DM.

    Authors: Hui-Lin Xu, Hong Fang, Wang-Hong Xu, Guo-You Qin, Yu-Jie Yan, Bao-Dong Yao, Nai-Qing Zhao, Yi-Nan Liu, Fen Zhang, Wei-Xi Li, Na Wang, Jie Zhou, Jin-Ling Zhang, Li-Yun Zhao, Lun-Qiang Li and Yan-Ping Zhao
    Citation: BMC Cancer 2015 15:852
    Content type: Research article Published on:

  5. The use of flaps in vulvar cancer-related reconstruction has been increasing, but few studies have evaluated the outcome and quality of life of patients after this surgery. The purpose of this study was to eva...

    Authors: Wei Zhang, Ang Zeng, Jiaxin Yang, Dongyan Cao, Xiaodong He, Xiaojun Wang, Yan You, Jie Chen, Jinghe Lang and Keng Shen
    Citation: BMC Cancer 2015 15:851
    Content type: Research article Published on:

  6. Comorbidity increases overall mortality in patients diagnosed with hematological malignancies. The impact of comorbidity on cancer-specific mortality, taking competing risks into account, has not been evaluated.

    Authors: Mohammad Mohammadi, Yang Cao, Ingrid Glimelius, Matteo Bottai, Sandra Eloranta and Karin E. Smedby
    Citation: BMC Cancer 2015 15:850
    Content type: Research article Published on:

  7. Increasing cervical screening coverage by reaching inadequately screened groups is essential for improving the effectiveness of cervical screening programs. Offering HPV self-sampling to women who are never or...

    Authors: Farhana Sultana, Robyn Mullins, Dallas R. English, Julie A. Simpson, Kelly T. Drennan, Stella Heley, C. David Wrede, Julia M. L. Brotherton, Marion Saville and Dorota M. Gertig
    Citation: BMC Cancer 2015 15:849
    Content type: Research article Published on:

  8. Liquid-state specimen carriers are inadequate for sample transportation in large-scale screening projects in low-resource settings, which necessitates the exploration of novel non-hazardous solid-state alterna...

    Authors: Shao-Ming Wang, Shang-Ying Hu, Wen Chen, Feng Chen, Fang-Hui Zhao, Wei He, Xin-Ming Ma, Yu-Qing Zhang, Jian Wang, Priya Sivasubramaniam and You-Lin Qiao
    Citation: BMC Cancer 2015 15:848
    Content type: Research article Published on:

  11. Activation of cyclooxygenase (COX)/prostaglandin and nuclear factor κB (NFκB) pathways can promote breast tumor initiation, growth, and progression to drug resistance and metastasis. Thus, anti-inflammatory dr...

    Authors: Irida Kastrati, Vladislav A. Litosh, Shuangping Zhao, Manuel Alvarez, Gregory R. J. Thatcher and Jonna Frasor
    Citation: BMC Cancer 2015 15:845
    Content type: Research article Published on:

  12. This study aimed to quantify the variation in oropharyngeal squamous cell carcinoma gross tumour volume (GTV) delineation between CT, MR and FDG PET-CT imaging.

    Authors: David Bird, Andrew F. Scarsbrook, Jonathan Sykes, Satiavani Ramasamy, Manil Subesinghe, Brendan Carey, Daniel J. Wilson, Neil Roberts, Gary McDermott, Ebru Karakaya, Evrim Bayman, Mehmet Sen, Richard Speight and Robin J.D. Prestwich
    Citation: BMC Cancer 2015 15:844
    Content type: Research article Published on:

  13. Poor prognosis in gallbladder cancer is due to late presentation of the disease, lack of reliable biomarkers for early diagnosis and limited targeted therapies. Early diagnostic markers and novel therapeutic t...

    Authors: Tejaswini Subbannayya, Pamela Leal-Rojas, Mustafa A. Barbhuiya, Remya Raja, Santosh Renuse, Gajanan Sathe, Sneha M. Pinto, Nazia Syed, Vishalakshi Nanjappa, Arun H. Patil, Patricia Garcia, Nandini A. Sahasrabuddhe, Bipin Nair, Rafael Guerrero-Preston, Sanjay Navani, Pramod K. Tiwari…
    Citation: BMC Cancer 2015 15:843
    Content type: Research article Published on:

  14. Cervical cancer (CC) is -second to breast cancer- a dominant cause of gynecological cancer-related deaths worldwide. CC tumor biopsies and blood samples are of easy access and vital for the development of futu...

    Authors: Charlotte Ngo, Sanne Samuels, Ksenia Bagrintseva, Andrea Slocker, Philippe Hupé, Gemma Kenter, Marina Popovic, Nina Samet, Patricia Tresca, Heiko von der Leyen, Eric Deutsch, Roman Rouzier, Lisa Belin, Maud Kamal and Suzy Scholl
    Citation: BMC Cancer 2015 15:842
    Content type: Study protocol Published on:

  15. Retinoblastoma (RB) is the most common malignant childhood tumor of the eye and results from inactivation of both alleles of the RB1 gene. Nowadays RB genetic diagnosis requires classical chromosome investigation...

    Authors: Simona Grotta, Gemma D’Elia, Rossana Scavelli, Silvia Genovese, Cecilia Surace, Pietro Sirleto, Raffaele Cozza, Antonino Romanzo, Maria Antonietta De Ioris, Paola Valente, Anna Cristina Tomaiuolo, Francesca Romana Lepri, Tiziana Franchin, Laura Ciocca, Serena Russo, Franco Locatelli…
    Citation: BMC Cancer 2015 15:841
    Content type: Research article Published on:

  16. Accumulation of tumor-infiltrating mast cells (MCs) predicts poor survival in several cancers after resection. However, its effect on the prognosis of patients with colorectal liver metastases (CRLM) is not kn...

    Authors: Shinsuke Suzuki, Yasushi Ichikawa, Kazuya Nakagawa, Takafumi Kumamoto, Ryutaro Mori, Ryusei Matsuyama, Kazuhisa Takeda, Mitsuyoshi Ota, Kuniya Tanaka, Tomohiko Tamura and Itaru Endo
    Citation: BMC Cancer 2015 15:840
    Content type: Research article Published on:

  17. Kv10.1, a voltage-gated potassium channel only detected in the healthy brain, was found to be aberrantly expressed in extracerebral cancers. Investigations of Kv10.1 in brain metastasis and glioblastoma multif...

    Authors: Ramón Martínez, Walter Stühmer, Sabine Martin, Julian Schell, Andrea Reichmann, Veit Rohde and Luis Pardo
    Citation: BMC Cancer 2015 15:839
    Content type: Research article Published on:

  18. Tamoxifen is the standard endocrine therapy for ER+ breast cancer; however, many women still relapse after long-term therapy. 3-Bromopyruvate, a glycolytic inhibitor, has shown high selective anti-tumor activity

    Authors: Yasmin M. Attia, Hanan S. EL-Abhar, Mahmoud M. Al Marzabani and Samia A. Shouman
    Citation: BMC Cancer 2015 15:838
    Content type: Research article Published on:

  19. Androgen deprivation therapy (ADT) administered as a prostate cancer treatment is known to exert multiple side effects including bone deterioration leading to bone fracture. The current analysis is to evaluate...

    Authors: Alice Wang, Zuzana Obertová, Charis Brown, Nishi Karunasinghe, Karen Bishop, Lynnette Ferguson and Ross Lawrenson
    Citation: BMC Cancer 2015 15:837
    Content type: Research article Published on:

  20. Durability of androgen-deprivation therapy (ADT) for prostate cancer (PC) is limited. Additional selective estrogen receptor modulators (SERMs) may prolong the durability of ADT, because androgen and estrogen ...

    Authors: Tetsuya Fujimura, Satoru Takahashi, Haruki Kume, Tomohiko Urano, Kenichi Takayama, Yuta Yamada, Motofumi Suzuki, Hiroshi Fukuhara, Tohru Nakagawa, Satoshi Inoue and Yukio Homma
    Citation: BMC Cancer 2015 15:836
    Content type: Research article Published on:

  21. Deregulation of cellular energetic metabolism was recently pointed out as a hallmark of cancer cells. This deregulation involves a metabolic reprogramming that leads to a high production of lactate. Lactate ef...

    Authors: Céline Pinheiro, Eduardo A. Garcia, Filipa Morais-Santos, Marise A. R. Moreira, Fábio M. Almeida, Luiz F. Jubé, Geraldo S. Queiroz, Élbio C. Paula, Maria A. Andreoli, Luisa L. Villa, Adhemar Longatto-Filho and Fátima Baltazar
    Citation: BMC Cancer 2015 15:835
    Content type: Research article Published on:

  22. The associations between pulmonary diseases (asthma, chronic obstructive pulmonary disease [COPD], and tuberculosis [TB]) and subsequent lung cancer risk have been reported, but few studies have investigated t...

    Authors: Jing-Yang Huang, Zhi-Hong Jian, Oswald Ndi Nfor, Wen-Yuan Ku, Pei-Chieh Ko, Chia-Chi Lung, Chien-Chang Ho, Hui-Hsien Pan, Chieh-Ying Huang, Yu-Chiu Liang and Yung-Po Liaw
    Citation: BMC Cancer 2015 15:834
    Content type: Research article Published on:

  23. SLFN11 was reported to be a predictive marker for DNA damage drugs. The study was to investigate whether SLFN11 expression is related to sensitivity to adjuvant oxaliplatin-based treatment in colorectal cancer.

    Authors: Yanhong Deng, Yue Cai, Yan Huang, Zihuan Yang, Yang Bai, Yanlu Liu, Xiuping Deng and Jianping Wang
    Citation: BMC Cancer 2015 15:833
    Content type: Research article Published on:

  24. Our previous studies show that β2-adrenergic receptor (β2-AR) is highly expressed in most Her2-overexpressing breast cancers. However, the mechanisms underlying upregulation of the β2-AR expression in Her2-ove...

    Authors: Dan Liu, Que Deng, Limin Sun, Tao Wang, Zhengyan Yang, Hongyu Chen, Liang Guo, Yanjun Liu, Yuanfang Ma, Ning Guo and Ming Shi
    Citation: BMC Cancer 2015 15:832
    Content type: Research article Published on:

  25. The etiological factor for intrahepatic cholangiocarcinoma (ICC) is not clear. Although it has been widely accepted that intrahepatic biliary tree stone is associated with increased risk of ICC, the role of ex...

    Authors: Hao Cai, Wen-Tao Kong, Chao-Bo Chen, Guo-Ming Shi, Cheng Huang, Ying-Hao Shen and Hui-Chuan Sun
    Citation: BMC Cancer 2015 15:831
    Content type: Research article Published on:

  26. This study aimed to explore the responses to the interleukin-6 (IL-6)/soluble interleukin-6 receptor (sIL-6R) complex in peritumoral endothelial cells (PECs) and tumor endothelial cells (TECs), as well as dete...

    Authors: Peng-Yuan Zhuang, Jian-Dong Wang, Zhao-Hui Tang, Xue-Ping Zhou, Zhi-Wei Quan, Ying-Bin Liu and Jun Shen
    Citation: BMC Cancer 2015 15:830
    Content type: Research article Published on:

  27. Cancer metastasis is a multi-step event including epithelial-to-mesenchymal transition (EMT). Breast cancer metastasis suppressor 1 (BRMS1) is a novel metastasis suppressor protein without anti-proliferating a...

    Authors: Kyung Hwa Cho, Seong-Lan Yu, Do Yeun Cho, Chang Gyo Park and Hoi Young Lee
    Citation: BMC Cancer 2015 15:829
    Content type: Research article Published on:

  28. Despite advances in therapeutics, outcomes for hepatocellular carcinoma (HCC) remain poor and there is an urgent need for efficacious systemic therapy. Unfortunately, drugs that are successful in preclinical s...

    Authors: Weining Wang, N. Gopalakrishna Iyer, Hsien Ts’ung Tay, Yonghui Wu, Tony K. H. Lim, Lin Zheng, In Chin Song, Chee Keong Kwoh, Hung Huynh, Patrick O. B. Tan and Pierce K. H. Chow
    Citation: BMC Cancer 2015 15:828
    Content type: Research article Published on:

  29. Population attributable risks (PARs) are useful tool to estimate the burden of risk factors in cancer incidence. Few studies estimated the PARs of oral cavity cancer to tobacco smoking alone, alcohol drinking ...

    Authors: Loredana Radoï, Gwenn Menvielle, Diane Cyr, Bénédicte Lapôtre-Ledoux, Isabelle Stücker and Danièle Luce
    Citation: BMC Cancer 2015 15:827
    Content type: Research article Published on:

  30. The 14-3-3 family is a group of intracellular proteins found in all eukaryotic organisms. Humans have seven isoforms that serve as scaffolds to promote interactions of regulatory phospho-proteins involved in m...

    Authors: Gavin M. Young, Vijayababu M. Radhakrishnan, Sara M. Centuori, Cecil J. Gomes and Jesse D. Martinez
    Citation: BMC Cancer 2015 15:826
    Content type: Research article Published on:

  31. HPV-associated HNSCCs have a distinct etiologic mechanism and better prognosis than those with non-HPV associated HNSCCs. However, even within the each group, there is heterogeneity in survival time. Here, we ...

    Authors: Shama Virani, Emily Bellile, Carol R. Bradford, Thomas E. Carey, Douglas B. Chepeha, Justin A. Colacino, Joseph I. Helman, Jonathan B. McHugh, Lisa A. Peterson, Maureen A. Sartor, Jeremy MG Taylor, Heather M. Walline, Greg T. Wolf and Laura S. Rozek
    Citation: BMC Cancer 2015 15:825
    Content type: Research article Published on:

  32. The role of methylation status of the thyroid stimulating hormone receptor gene (TSHr) in the discrimination of benign and malignant thyroid nodules has already been studied using paraffin blocks and cell line...

    Authors: Kinyas Kartal, Sevgen Onder, Kemal Kosemehmetoglu, Sadettin Kilickap, Yesim Gaye Tezel and Volkan Kaynaroglu
    Citation: BMC Cancer 2015 15:824
    Content type: Research article Published on:

  33. Elevated mammographic density (MD) is a strong breast cancer risk factor but the mechanisms underlying the association are poorly understood. High MD and breast cancer risk may reflect cumulative exposures to ...

    Authors: Clara Bodelon, Christopher M. Heaphy, Alan K. Meeker, Berta Geller, Pamela M. Vacek, Donald L. Weaver, Rachael E. Chicoine, John A. Shepherd, Amir Pasha Mahmoudzadeh, Deesha A. Patel, Louise A. Brinton, Mark E. Sherman and Gretchen L. Gierach
    Citation: BMC Cancer 2015 15:823
    Content type: Research article Published on:

  34. To investigate the accuracy of core needle biopsy (CNB) in evaluating breast cancer estrogen receptor (ER), progesterone receptor (PR), HER2, and Ki67 status and to identify factors which might be associated w...

    Authors: Xiaosong Chen, Siji Zhu, Xiaochun Fei, David H. Garfield, Jiayi Wu, Ou Huang, Yafen Li, Li Zhu, Jianrong He, Weiguo Chen, Xiaolong Jin and Kunwei Shen
    Citation: BMC Cancer 2015 15:822
    Content type: Research article Published on:

  35. Hepatitis B virus (HBV) infection is a major risk factor which can lead to development of hepatocellular carcinoma (HCC). In this study, we aimed to explore the effects of toll-like receptor 4 (TLR4) downregul...

    Authors: Yiting Wang, Jing Cai, Xiaoli Zeng, Yajie Chen, Wei Yan, Yuming Ouyang, Dan Xiao, Zhiming Zeng, Long Huang and Anwen Liu
    Citation: BMC Cancer 2015 15:821
    Content type: Research article Published on:

  36. This study aimed to answer the question ‘for which cancers, in a symptomatic patient, does expediting the diagnosis provide an improvement in mortality and/or morbidity?’

    Authors: Willie Hamilton, Sally Stapley, Christine Campbell, Georgios Lyratzopoulos, Greg Rubin and Richard D. Neal
    Citation: BMC Cancer 2015 15:820
    Content type: Research article Published on:

  37. Annually, colorectal cancer (CRC) is diagnosed in >1.4 million subjects worldwide and incidence is increasing. Much effort has therefore been focused on screening, which has proven to reduce cancer-related mor...

    Authors: Mai-Britt W. Ørntoft, Hans J. Nielsen, Torben F. Ørntoft and Claus L. Andersen
    Citation: BMC Cancer 2015 15:819
    Content type: Research article Published on:

  38. A new molecular marker of carcinoma in the urinary bladder is needed as a diagnostic tool or as a therapeutic target. Potential markers include microRNAs (miRNAs), which are short, low molecular weight RNAs 19...

    Authors: Tomomi Fujii, Keiji Shimada, Yoshihiro Tatsumi, Kinta Hatakeyama, Chiho Obayashi, Kiyohide Fujimoto and Noboru Konishi
    Citation: BMC Cancer 2015 15:818
    Content type: Research article Published on:

  39. Impairment of homologous recombination (HR) is found in close to 50 % of ovarian and breast cancer. Tumors with BRCA1 mutations show increased expression of the Insulin-like growth factor type 1 receptor (IGF-1R)...

    Authors: Oreekha Amin, Marie-Claude Beauchamp, Paul Abou Nader, Ido Laskov, Sanaa Iqbal, Charles-André Philip, Amber Yasmeen and Walter H. Gotlieb
    Citation: BMC Cancer 2015 15:817
    Content type: Research article Published on:

  40. Breast cancer formation is associated with frequent changes in DNA methylation but the extent of very early alterations in DNA methylation and the biological significance of cancer-associated epigenetic change...

    Authors: Garth H. Rauscher, Jacob K. Kresovich, Matthew Poulin, Liying Yan, Virgilia Macias, Abeer M. Mahmoud, Umaima Al-Alem, Andre Kajdacsy-Balla, Elizabeth L. Wiley, Debra Tonetti and Melanie Ehrlich
    Citation: BMC Cancer 2015 15:816
    Content type: Research article Published on:

  41. The role of extranodal extension (ENE) in penile cancer is controversial and has not been well studied. The aim of this study was to investigate the importance of ENE in predicting prognosis and presence of pe...

    Authors: Zhi-Ling Zhang, Chun-Ping Yu, Zhuo-Wei Liu, Liliya Velet, Yong-Hong Li, Li-Juan Jiang and Fang-Jian Zhou
    Citation: BMC Cancer 2015 15:815
    Content type: Research article Published on:

  42. Studies have described vasculogenic mimicry (VM) as an alternative circulatory system to blood vessels in multiple malignant tumor types, including hepatocellular carcinoma (HCC). In the current study, we aime...

    Authors: Ji-Gang Zhang, Dan-Dan Zhang, Xin Wu, Yu-Zhu Wang, Sheng-Ying Gu, Guan-Hua Zhu, Xiao-Yu Li, Qin Li and Gao-Lin Liu
    Citation: BMC Cancer 2015 15:814
    Content type: Research article Published on:

  43. To evaluate the long-term results of chemoradiotherapy (CRT) for stage II-III thoracic esophageal cancer mainly by comparing results of three protocols retrospectively.

    Authors: Rei Umezawa, Keiichi Jingu, Haruo Matsushita, Toshiyuki Sugawara, Masaki Kubozono, Takaya Yamamoto, Yojiro Ishikawa, Maiko Kozumi, Noriyoshi Takahashi, Yu Katagiri, Noriyuki Kadoya, Ken Takeda, Hisanori Ariga, Kenji Nemoto and Shogo Yamada
    Citation: BMC Cancer 2015 15:813
    Content type: Research article Published on:

  44. Platinum-based systemic chemotherapy is the treatment of choice for patients with advanced urothelial carcinoma (UC). Although no chemotherapeutic regimen is established as a second-line therapy, recent studie...

    Authors: Ki Hong Kim, Sung Joon Hong and Kyung Seok Han
    Citation: BMC Cancer 2015 15:812
    Content type: Research article Published on:

  45. Stem cell protein Piwil1 functions as an oncogene in various tumor types. However, the exact function and mechanism of Piwil1 in endometrial cancer remains unclear.

    Authors: Zheng Chen, Qi Che, Xiaoying He, Fangyuan Wang, Huihui Wang, Minjiao Zhu, Jing Sun and Xiaoping Wan
    Citation: BMC Cancer 2015 15:811
    Content type: Research article Published on:

  46. To compare the survival outcomes and acute toxicities of concurrent chemoradiotherapy (CCRT), induction chemotherapy (IC) plus radiotherapy (RT), and IC plus CCRT in patients with locoregionally advanced nasop...

    Authors: Wen-Fei Li, Ying-Qin Li, Lei Chen, Yuan Zhang, Rui Guo, Fan Zhang, Hao Peng, Ying Sun and Jun Ma
    Citation: BMC Cancer 2015 15:810
    Content type: Research article Published on:

  47. The expression status of apoptotic regulators, such as caspases and inhibitors of apoptosis proteins (IAPs), could reflect the aggressiveness of tumors and, therefore, could be useful as prognostic markers. We...

    Authors: Gonzalo Rodríguez-Berriguete, Norelia Torrealba, Miguel Angel Ortega, Pilar Martínez-Onsurbe, Gabriel Olmedilla, Ricardo Paniagua, Manuel Guil-Cid, Benito Fraile and Mar Royuela
    Citation: BMC Cancer 2015 15:809
    Content type: Research article Published on:

  48. The anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (moAbs) cetuximab or panitumumab are administered to colorectal cancer (CRC) patients who harbor wild-type RAS proto-oncogenes. However, a pe...

    Authors: Laura Lupini, Cristian Bassi, Jitka Mlcochova, Gentian Musa, Marta Russo, Petra Vychytilova-Faltejskova, Marek Svoboda, Silvia Sabbioni, Radim Nemecek, Ondrej Slaby and Massimo Negrini
    Citation: BMC Cancer 2015 15:808
    Content type: Research article Published on:

  49. Malignant melanoma is an aggressive type of skin cancer, and despite recent advances in treatment, the survival rate of the metastatic form remains low. Nifuroxazide analogues are drugs based on the substituti...

    Authors: C. F. Farias, M. H. Massaoka, N. Girola, R. A. Azevedo, A. K. Ferreira, S. D. Jorge, L. C. Tavares, C. R. Figueiredo and L. R. Travassos
    Citation: BMC Cancer 2015 15:807
    Content type: Research article Published on:

  50. There is significant evidence that severe tumor hypoxia may cause resistance to chemoradiotherapy and promote metastatic spread in locally advanced carcinoma of the uterine cervix. Some clinical investigations...

    Authors: Christine Ellingsen, Lise Mari K. Andersen, Kanthi Galappathi and Einar K. Rofstad
    Citation: BMC Cancer 2015 15:805
    Content type: Research article Published on:

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