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  1. Membrane androgen receptors (mAR) are functionally expressed in a variety of tumor-cells including the breast tumor-cell line MCF-7. They are specifically activated by testosterone albumin conjugates (TAC). Th...

    Authors: Guilai Liu, Sabina Honisch, Guoxing Liu, Sebastian Schmidt, Saad Alkahtani, Abdullah A. AlKahtane, Christos Stournaras and Florian Lang
    Citation: BMC Cancer 2015 15:995
    Content type: Research article Published on:

  2. Decreasing trends of nasopharyngeal carcinoma (NPC) incidence have been consistently reported in endemic populations but the etiology of NPC remains unclear. The objective of our study was to assess the intern...

    Authors: Zhi-Ming Mai, Ching-Man Lo, Jun Xu, King-Pan Chan, Chit-Ming Wong, Maria Li Lung and Tai-Hing Lam
    Citation: BMC Cancer 2015 15:994
    Content type: Research article Published on:

  3. Hypereosinophilia, defined by an absolute eosinophil count of more than 1500/mm3, is rarely observed in patients treated for cancer, and rarely imputable to anti-cancer agents. Drug-induced hypereosinophilia u...

    Authors: Diaddin Hamdan, Christophe Leboeuf, Cathy Pereira, Nathalie Jourdan, Laurence Verneuil, Guilhem Bousquet and Anne Janin
    Citation: BMC Cancer 2015 15:993
    Content type: Case report Published on:

  4. Given evidence shows physical activity, a healthful diet and weight management can improve cancer outcomes and reduce chronic disease risk, the major cancer organisations and health authorities have endorsed r...

    Authors: Elizabeth G. Eakin, Sandra C. Hayes, Marion R. Haas, Marina M. Reeves, Janette L. Vardy, Frances Boyle, Janet E. Hiller, Gita D. Mishra, Ana D. Goode, Michael Jefford, Bogda Koczwara, Christobel M. Saunders, Wendy Demark-Wahnefried, Kerry S. Courneya, Kathryn H. Schmitz, Afaf Girgis…
    Citation: BMC Cancer 2015 15:992
    Content type: Study protocol Published on:

  5. The study was to investigate whether 18F-fluorodeoxyglucose (18F-FDG) uptake, analyzed by positron emission tomography (PET), can be used preoperatively to predict survival in Chinese patients with colorectal car...

    Authors: Debing Shi, Guoxiang Cai, Junjie Peng, Dawei Li, Xinxiang Li, Ye Xu and Sanjun Cai
    Citation: BMC Cancer 2015 15:991
    Content type: Research article Published on:

  6. Retinoblastoma protein-interacting zinc-finger gene 1 (RIZ1) displays strong tumor suppressive activities, and its expression is often silenced in many types of human tumors. However, the relationship between ...

    Authors: Chenran Zhang, Qiubei Zhu, Hua He, Lei Jiang, Qiang Qiang, Liuhua Hu, Guohan Hu, Ying Jiang, Xuehua Ding and Yicheng Lu
    Citation: BMC Cancer 2015 15:990
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2016 16:26

  7. To investigate the prognostic significance of patient characteristics and clinical laboratory test results in locally advanced non-small cell lung cancer (NSCLC), and in particular the impact of diabetes melli...

    Authors: Hisao Imai, Kyoichi Kaira, Keita Mori, Akira Ono, Hiroaki Akamatsu, Shunichi Matsumoto, Tetsuhiko Taira, Hirotsugu Kenmotsu, Hideyuki Harada, Tateaki Naito, Haruyasu Murakami, Masahiro Endo, Takashi Nakajima, Masanobu Yamada and Toshiaki Takahashi
    Citation: BMC Cancer 2015 15:989
    Content type: Research article Published on:

  8. Lung cancer is the leading cause of cancer deaths worldwide. Surgery, radiotherapy at conventional and high dose and chemotherapy are the mainstay for lung cancer treatment. Insufficient migration and activati...

    Authors: Seyer Safi, Philipp Beckhove, Arne Warth, Axel Benner, Falk Roeder, Stefan Rieken, Juergen Debus, Hendrik Dienemann, Hans Hoffmann and Peter E. Huber
    Citation: BMC Cancer 2015 15:988
    Content type: Study protocol Published on:

  9. To assess the significance of alpha-fetoprotein (AFP) normalization as a prognostic surrogate after stereotactic body radiotherapy (SBRT) for patients with small hepatocellular carcinoma (HCC).

    Authors: Jinhong Jung, Sang Min Yoon, Seungbong Han, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, So Yeon Kim, Jin-hong Park and Jong Hoon Kim
    Citation: BMC Cancer 2015 15:987
    Content type: Research article Published on:

  10. Triple negative breast cancers (TNBC) are a more aggressive subset of breast cancer. A better understanding of its biology could allow the rational development of targeted therapies.

    Authors: William Jacot, Caroline Mollevi, Frédéric Fina, Evelyne Lopez-Crapez, Pierre-Marie Martin, Pierre-Emmanuel Colombo, Frédéric Bibeau, Gilles Romieu and Pierre-Jean Lamy
    Citation: BMC Cancer 2015 15:986
    Content type: Research article Published on:

  11. Chronic hepatitis B (CHB) virus infection is a major cause of hepatocellular carcinoma (HCC), as late diagnosis is the main factor for the poor survival of patients. There is an urgent need for accurate biomar...

    Authors: Ana Maria Passos-Castilho, Valdemir Melechco Carvalho, Karina Helena Morais Cardozo, Luciana Kikuchi, Aline Lopes Chagas, Michele Soares Gomes-Gouvêa, Fernanda Malta, Ana Catharina de Seixas-Santos Nastri, João Renato Rebello Pinho, Flair José Carrilho and Celso Francisco Hernandes Granato
    Citation: BMC Cancer 2015 15:985
    Content type: Research article Published on:

  12. Anaplastic thyroid carcinoma is the most undifferentiated form of thyroid cancer and one of the deadliest of all adult solid malignancies. Here we report the first genomic and transcriptomic profile of anaplas...

    Authors: Katayoon Kasaian, Sam M. Wiseman, Blair A. Walker, Jacqueline E. Schein, Yongjun Zhao, Martin Hirst, Richard A. Moore, Andrew J. Mungall, Marco A. Marra and Steven JM Jones
    Citation: BMC Cancer 2015 15:984
    Content type: Research article Published on:

  13. The MexTAg transgenic mouse model of mesothelioma replicates many aspects of human mesothelioma, including induction by asbestos, pathogenicity and response to cytotoxic chemotherapy, despite high levels of th...

    Authors: Cleo Robinson, Ian M. Dick, Michael J. Wise, Andrew Holloway, Dileepa Diyagama, Bruce W. S. Robinson, Jenette Creaney and Richard A. Lake
    Citation: BMC Cancer 2015 15:983
    Content type: Research article Published on:

  14. This study was aimed at identifying prognostic biomarkers for stage II-IIIA non-small cell lung cancer (NSCLC) according to histology and at investigating the effect of vorinostat on the expression of these bi...

    Authors: Eunju Lee, DongHao Jin, Bo Bin Lee, Yujin Kim, Joungho Han, Young Mog Shim and Duk-Hwan Kim
    Citation: BMC Cancer 2015 15:982
    Content type: Research article Published on:

  15. The composition of the matrix molecules is important in in vitro cell culture experiments of e.g. human cancer invasion and vessel formation. Currently, the mouse Engelbreth-Holm-Swarm (EHS) sarcoma -derived prod...

    Authors: Tuula Salo, Meeri Sutinen, Ehsanul Hoque Apu, Elias Sundquist, Nilva K. Cervigne, Carine Ervolino de Oliveira, Saad Ullah Akram, Steffen Ohlmeier, Fumi Suomi, Lauri Eklund, Pirjo Juusela, Pirjo Åström, Carolina Cavalcante Bitu, Markku Santala, Kalle Savolainen, Johanna Korvala…
    Citation: BMC Cancer 2015 15:981
    Content type: Research article Published on:

  16. Selected patients with peritoneal carcinomatosis (PC) from colorectal cancer (CRC) benefit from cytoreductive surgery (CRS) combined with intraperitoneal chemoperfusion (IPC). However, even after optimal cytor...

    Authors: Wouter Willaert, Kurt Van Der Speeten, Gabriel Liberale and Wim Ceelen
    Citation: BMC Cancer 2015 15:980
    Content type: Study protocol Published on:

  17. Methylation is a common epigenetic modification which may play a crucial role in cancer development. To investigate the association between methylation of COX-2 in blood leukocyte DNA and risk of gastric cancer (...

    Authors: Hui-juan Su, Yang Zhang, Lian Zhang, Jun-ling Ma, Ji-You Li, Kai-feng Pan and Wei-cheng You
    Citation: BMC Cancer 2015 15:979
    Content type: Research article Published on:

  18. Personalized therapy considering clinical and genetic patient characteristics will further improve breast cancer survival. Two widely used treatments, chemotherapy and radiotherapy, can induce oxidative DNA da...

    Authors: Petra Seibold, Peter Schmezer, Sabine Behrens, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Dieter Flesch-Janys, Heli Nevanlinna, Rainer Fagerholm, Kristiina Aittomäki, Carl Blomqvist, Sara Margolin, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M. Hartikainen…
    Citation: BMC Cancer 2015 15:978
    Content type: Research article Published on:

  19. The impact of cumulative dose of cisplatin on clinical outcomes of nasopharyngeal carcinoma (NPC) patients who received intensity-modulated radiotherapy (IMRT) was evaluated.

    Authors: Shan-Shan Guo, Lin-Quan Tang, Lu Zhang, Qiu-Yan Chen, Li-Ting Liu, Ling Guo, Hao-Yuan Mo, Dong-Hua Luo, Pei-Yu Huang, Yan-Qun Xiang, Rui Sun, Ming-Yuan Chen, Lin Wang, Xing Lv, Chong Zhao, Xiang Guo…
    Citation: BMC Cancer 2015 15:977
    Content type: Research article Published on:

  20. Lymph nodes’ examination in colorectal cancer (CRC) resection specimens is an important determinant that aids in the accuracy of CRC staging and treatment outcomes. Current guidelines call for the examination ...

    Authors: Hassan Ashktorab, Temitayo Ogundipe, Hassan Brim, Anahita Shahnazi, Adeyinka O. Laiyemo, Edward Lee, Babak Shokrani and Mehdi Nouraie
    Citation: BMC Cancer 2015 15:976
    Content type: Research article Published on:

  21. Colorectal cancer (CRC) is among the five most frequent causes for cancer-related deaths in Europe. One of the most important tumor-associated antigens for CRC is carcinoembryonic antigen-related cell adhesion...

    Authors: Reinhild Holmer, Georg H. Wätzig, Sanjay Tiwari, Stefan Rose-John and Holger Kalthoff
    Citation: BMC Cancer 2015 15:975
    Content type: Research article Published on:

  24. Rare sites of metastases, atypical symptoms and paraneoplastic syndromes are often neglected or misinterpreted, especially when they represent early symptoms of an underlying malignant disease. Hence, an inter...

    Authors: Sebastian P. Haen, Philipp Stroebel, Alexander Marx, Daniela Suesskind, Falko Fend, Ursula Reichmann, Hans-Georg Kopp, Lothar Kanz and Frank Mayer
    Citation: BMC Cancer 2015 15:972
    Content type: Case report Published on:

  25. It has recently been proposed that the M-type phospholipase A2 receptor (PLA2R1) acts as a tumour suppressor in certain malignancies including mammary cancer. Considering that DNA methylation is an important regu...

    Authors: Mario Menschikowski, Albert Hagelgans, Brit Nacke, Carsten Jandeck, Olga Sukocheva and Gabriele Siegert
    Citation: BMC Cancer 2015 15:971
    Content type: Research article Published on:

  26. Silence of the tumor suppressor miR-34c is implicated in the development of colorectal cancer (CRC). For the past few years, Resveratrol (Res) has been introduced to oncotherapies alone or with traditional chemot...

    Authors: Shu Yang, Wenshuai Li, Haimei Sun, Bo Wu, Fengqing Ji, Tingyi Sun, Huanhuan Chang, Ping Shen, Yaxi Wang and Deshan Zhou
    Citation: BMC Cancer 2015 15:969
    Content type: Research article Published on:

  27. HPV FOCAL is a randomized trial (ISRCTN79347302, registered 20 Apr 2007) comparing high-risk (hr) HPV testing vs. liquid-based cytology (LBC) for cervical cancer screening of women aged 25–65. We compared the ...

    Authors: Darrel A. Cook, Wendy Mei, Laurie W. Smith, Dirk J. van Niekerk, Kathy Ceballos, Eduardo L. Franco, Andrew J. Coldman, Gina S. Ogilvie and Mel Krajden
    Citation: BMC Cancer 2015 15:968
    Content type: Research article Published on:

  28. The main aim of this study was to investigate pre- and post-diagnostic physical activity (PA) levels, as well as changes in pre- and post-diagnostic PA levels, and their association with all-cause and breast c...

    Authors: Kristin Benjaminsen Borch, Tonje Braaten, Eiliv Lund and Elisabete Weiderpass
    Citation: BMC Cancer 2015 15:967
    Content type: Research article Published on:

  29. High intake of dietary calcium has been thought to be a protective factor against colorectal cancer. To explore the dose-response relationship in the associations between dietary calcium intake and colorectal ...

    Authors: Changwoo Han, Aesun Shin, Jeonghee Lee, Jeeyoo Lee, Ji Won Park, Jae Hwan Oh and Jeongseon Kim
    Citation: BMC Cancer 2015 15:966
    Content type: Research article Published on:

  30. Metastasis is the major cause of death in breast cancers. MMPs play a key role in tumor microenvironment that facilitates metastasis. The existing researches suggest that the high expression of gelatinase A an...

    Authors: Shimin Pei, Xu Yang, Huanan Wang, Hong Zhang, Bin Zhou, Di Zhang and Degui Lin
    Citation: BMC Cancer 2015 15:965
    Content type: Research article Published on:

  32. Deletions of chromosome 10q23, including the PTEN (phosphatase and tensin homolog) locus, are known to occur in breast cancer, but systematic analyses of its clinical relevance are lacking.

    Authors: P. Lebok, V. Kopperschmidt, M. Kluth, C. Hube-Magg, C. Özden, Taskin B., K. Hussein, A. Mittenzwei, A. Lebeau, I. Witzel, L. Wölber, S. Mahner, F. Jänicke, S. Geist, P. Paluchowski, C. Wilke…
    Citation: BMC Cancer 2015 15:963
    Content type: Research article Published on:

  33. 2,9-Bis[2-(pyrrolidin-1-yl)ethoxy]-6-{4-[2-(pyrrolidin-1-yl)ethoxy] phenyl}-11H-indeno[1,2-c]quinolin-11-one (BPIQ) is a derivative from 6-arylindeno[1,2-c]quinoline. Our previous study showed the anti-cancer pot...

    Authors: Chien-Chih Chiu, Han-Lin Chou, Bing-Hung Chen, Kuo-Feng Chang, Chih-Hua Tseng, Yao Fong, Tzu-Fun Fu, Hsueh-Wei Chang, Chang-Yi Wu, Eing-Mei Tsai, Shinne-Ren Lin and Yeh-Long Chen
    Citation: BMC Cancer 2015 15:962
    Content type: Research article Published on:

  34. KIF23 (kinesin family member 23) is a kinesin-like motor protein and plays an important role in cytokinesis. In search for genes associated with hepatocellular carcinoma (HCC) by cDNA microarray, we found that...

    Authors: Xiaotong Sun, Zhongtian Jin, Xiao Song, Jingjing Wang, Yan Li, Xiaoping Qian, Yu zhang and Yanhui Yin
    Citation: BMC Cancer 2015 15:961
    Content type: Research article Published on:

  35. Nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to inhibit several pathways in experimental models of breast carcinogenesis, but epidemiological evidence remains insufficient to support their use...

    Authors: Sangmi Kim, David L. Shore, Lauren E. Wilson, Ethel I. Sanniez, Jae H. Kim, Jack A. Taylor and Dale P. Sandler
    Citation: BMC Cancer 2015 15:960
    Content type: Research article Published on:

  36. Surgery and stereotactic ablative radiotherapy (SABR) are both curative treatment options for patients with a stage I non-small cell lung cancer (NSCLC). Consequently, there is growing interest in studying the...

    Authors: Wendy Hopmans, Olga C. Damman, Suresh Senan, Koen J. Hartemink, Egbert F. Smit and Danielle R. M. Timmermans
    Citation: BMC Cancer 2015 15:959
    Content type: Research article Published on:

  37. Flavones found in plants display various biological activities, including anti-allergic, anti-viral, anti-inflammatory, anti-oxidation, and anti-tumor effects. In this study, we investigated the anti-tumor eff...

    Authors: Chia-Hung Lin, Ching-Yao Chang, Kuan-Rong Lee, Hui-Ju Lin, Ter-Hsin Chen and Lei Wan
    Citation: BMC Cancer 2015 15:958
    Content type: Research article Published on:

  38. The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, erlotinib, has been clinically applied for the treatment of a variety of tumors with EGFR overexpression. A phase II clinical study of erl...

    Authors: Toshio Nishimura, Kazuto Nakamura, Soichi Yamashita, Sadatomo Ikeda, Keiko Kigure and Takashi Minegishi
    Citation: BMC Cancer 2015 15:957
    Content type: Research article Published on:

  39. As ovarian cancer stem cells (CSCs) are responsible for tumor initiation, invasion, metastasis, and chemo-resistance, new stratagems that selectively target ovarian CSCs are critically significant. Our previou...

    Authors: Xiaofen Yao, Zhangli Dong, Qiuwan Zhang, Qian Wang and Dongmei Lai
    Citation: BMC Cancer 2015 15:956
    Content type: Research article Published on:

  40. High tumour stromal content has been found to predict adverse clinical outcome in a range of epithelial tumours. The aim of this study was to assess the prognostic significance of tumour-stroma ratio (TSR) in ...

    Authors: Hannah Panayiotou, Nicolas M. Orsi, Helene H. Thygesen, Alexander I. Wright, Matthew Winder, Richard Hutson and Michele Cummings
    Citation: BMC Cancer 2015 15:955
    Content type: Research article Published on:

  41. The tumor suppressor gene CDH1 is critical for intercellular adhesion. In our previous work, we reported a nonfunctional CDH1 transcript that lacks the final 83 base pairs of exon 8 (1054del83). In this work, we ...

    Authors: Xiao-Wei Li, Bing-Yu Shi, Qing-Lan Yang, Jie Wu, Hui-Min Wu, Yu-Feng Wang, Zhi-Jiao Wu, Yi-Mei Fan and Ya-Ping Wang
    Citation: BMC Cancer 2015 15:954
    Content type: Research article Published on:

  42. Several studies have shown, that circulating tumor cells (CTC) have a negative prognostic value in colorectal cancer patients. Aim of this study was to evaluate the role of CTC in specifically rectal cancer pa...

    Authors: Sebastian Hinz, Christian Röder, Jürgen Tepel, Alexander Hendricks, Clemens Schafmayer, Thomas Becker and Holger Kalthoff
    Citation: BMC Cancer 2015 15:953
    Content type: Research article Published on:

  43. Astrocytomas are the most common primary brain tumors distinguished into four histological grades. Molecular analyses of individual astrocytoma grades have revealed detailed insights into genetic, transcriptom...

    Authors: Michael Seifert, Martin Garbe, Betty Friedrich, Michel Mittelbronn and Barbara Klink
    Citation: BMC Cancer 2015 15:952
    Content type: Research Article Published on:

  44. Current knowledge indicate that epirubicin administration in late pregnancy is almost devoid of any fetal cardiotoxicity. We report a twin pregnancy complicated by breast cancer in which epirubicin administrat...

    Authors: Marialuisa Framarino-dei-Malatesta, Giuseppina Perrone, Antonella Giancotti, Flavia Ventriglia, Martina Derme, Isabella Iannini, Valentina Tibaldi, Paola Galoppi, Paolo Sammartino, Gianluca Cascialli and Roberto Brunelli
    Citation: BMC Cancer 2015 15:951
    Content type: Case report Published on:

  46. To compare the efficacy and toxicity of irinotecan-based chemotherapy (IBC) and non-irinotecan-based chemotherapy (NIBC) as first-line treatment for stage IIIB/IV non-small cell lung cancer (NSCLC).

    Authors: Xue-Qin Yang, Chong-Yi Li, Ming-Fang Xu, Hong Zhao and Dong Wang
    Citation: BMC Cancer 2015 15:949
    Content type: Research article Published on:

  48. The receptor tyrosine kinase (RTK) EGFR is overexpressed and mutated in NSCLC. These mutations can be targeted by RTK inhibitors (TKIs) such as erlotinib. Chromatin-modifying agents may offer a novel therapeut...

    Authors: Gabriele Greve, Insa Schiffmann, Dietmar Pfeifer, Milena Pantic, Julia Schüler and Michael Lübbert
    Citation: BMC Cancer 2015 15:947
    Content type: Research article Published on:

  49. We examined the anti-tumor effect and radiosensitizing potential of a small molecule inhibitor of fibroblast growth factor receptor (FGFR) in colorectal cancer (CRC) in vitro and in vivo.

    Authors: Maud Verstraete, Annelies Debucquoy, Annelies Gonnissen, Ruveyda Dok, Sofie Isebaert, Ellen Devos, William McBride and Karin Haustermans
    Citation: BMC Cancer 2015 15:946
    Content type: Research article Published on:

  50. Adults in the United States (U.S) can be simultaneously exposed to more than one social risk factor over their lifetime. However, cancer epidemiology tends to focus on single social risk factors at a time. We ...

    Authors: Rishi Caleyachetty, Parisa Tehranifar, Jeanine M. Genkinger, Justin B. Echouffo-Tcheugui and Peter Muennig
    Citation: BMC Cancer 2015 15:945
    Content type: Research article Published on:

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