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  1. In South and Southeast Asian, the majority of buccal squamous cell carcinoma (BSCC) can arise from oral submucous fibrosis (OSF). BSCCs develop in OSF that are often not completely resected, causing local rela...

    Authors: Wen Liu, Lijuan Zeng, Ning Li, Fei Wang, Canhua Jiang, Feng Guo, Xinqun Chen, Tong Su, Chunjiao Xu, Shanshan Zhang and Changyun Fang
    Citation: BMC Cancer 2016 16:584
    Content type: Research article Published on:

  2. Long noncoding RNAs (lncRNAs) play crucial roles in tumorigenesis, and lncRNA taurine-upregulated gene 1 (TUG1) has been proven to be associated with several human cancers. However, the mechanisms of TUG1-involve...

    Authors: Pei-Chin Lin, Hsien-Da Huang, Chun-Chi Chang, Ya-Sian Chang, Ju-Chen Yen, Chien-Chih Lee, Wen-Hsin Chang, Ta-Chih Liu and Jan-Gowth Chang
    Citation: BMC Cancer 2016 16:583
    Content type: Research article Published on:

  3. Three-dimensional (3-D) cultures of cancer cells can potentially bridge the gap between 2-D drug screening and in vivo xenografts. The objective of this study was to characterize the cellular and extracellular...

    Authors: Surya P. Lamichhane, Neha Arya, Esther Kohler, Shengnan Xiang, Jon Christensen and V. Prasad Shastri
    Citation: BMC Cancer 2016 16:581
    Content type: Research article Published on:

  4. To identify predictors of prolonged or shortened progression-free survival (PFS) and overall survival (OS) among patients with metastatic renal cell carcinoma (mRCC) who received first-line targeted therapies.

    Authors: Sung Han Kim, Sohee Kim, Jungnam Joo, Ho Kyung Seo, Jae Young Joung, Kang Hyun Lee and Jinsoo Chung
    Citation: BMC Cancer 2016 16:577
    Content type: Research article Published on:

  5. Accumulating evidences have demonstrated that mesenchymal stem cells (MSC) could be recruited to the tumor microenvironment. Umbilical cord mesenchymal stem cells (UCMSC) were attractive vehicles for deliverin...

    Authors: Chang Liu, Yang Liu, Xiao-xi Xu, Xin Guo, Guang-wei Sun and Xiao-jun Ma
    Citation: BMC Cancer 2016 16:566
    Content type: Research article Published on:

  6. Collapsin response mediator proteins (CRMPs) were originally identified in the nervous system and are involved in neuronal development. Similar to CRMP1, CRMP4 has a shorter transcript encoding a short isoform...

    Authors: Haijian Guo and Bing Xia
    Citation: BMC Cancer 2016 16:565
    Content type: Research article Published on:

  7. Hyponatremia is prognostic of higher mortality in some cancers but has not been well studied in others. We used a longitudinal design to determine the incidence and prognostic importance of euvolemic and hyper...

    Authors: Jorge J. Castillo, Ilya G. Glezerman, Susan H. Boklage, Joseph Chiodo III, Beni A. Tidwell, Lois E. Lamerato and Kathy L. Schulman
    Citation: BMC Cancer 2016 16:564
    Content type: Research article Published on:

  8. Primary invasive Extramammary Paget’s vulvar disease is a rare tumor that is challenging to control. Wide surgical excision represents the standard treatment approach for Primary invasive Extramammary Paget’s ...

    Authors: Maria Tolia, Nikolaos Tsoukalas, Chrisostomos Sofoudis, Constantinos Giaginis, Despoina Spyropoulou, Dimitrios Kardamakis, Vasileios Kouloulias and George Kyrgias
    Citation: BMC Cancer 2016 16:563
    Content type: Debate Published on:

  9. Coffee contains biologically-active substances that suppress carcinogenesis in vivo, and coffee consumption has been associated with a lower risk of malignant melanoma. We studied the impact of total coffee consu...

    Authors: Marko Lukic, Mie Jareid, Elisabete Weiderpass and Tonje Braaten
    Citation: BMC Cancer 2016 16:562
    Content type: Research article Published on:

  10. Colorectal cancer (CRC) is the third leading cause of cancer related deaths worldwide both in men and women. Our recent studies have indicated an association of heat shock protein 70–2 (HSP70-2) with bladder u...

    Authors: Nirmala Jagadish, Deepak Parashar, Namita Gupta, Sumit Agarwal, Vaishali Suri, Rajive Kumar, Vitusha Suri, Trilok Chand Sadasukhi, Anju Gupta, Abdul S. Ansari, Nirmal Kumar Lohiya and Anil Suri
    Citation: BMC Cancer 2016 16:561
    Content type: Research article Published on:

  11. SLC52A3 was recently identified as a susceptibility gene for esophageal squamous cell carcinoma (ESCC). However, associations between the single nucleotide polymorphisms (SNPs) rs13042...

    Authors: Hua-Zhen Tan, Zhi-Yong Wu, Jian-Yi Wu, Lin Long, Ji-Wei Jiao, Yu-Hui Peng, Yi-Wei Xu, Shan-Shan Li, Wei Wang, Jian-Jun Zhang, En-Min Li and Li-Yan Xu
    Citation: BMC Cancer 2016 16:560
    Content type: Research article Published on:

  12. Breast cancer is a complex heterogeneous disease where many distinct subtypes are found. Younger African American (AA) women often present themselves with aggressive form of breast cancer with unique biology w...

    Authors: Luis Martinez, Easter Thames, Jinna Kim, Gautam Chaudhuri, Rajan Singh and Shehla Pervin
    Citation: BMC Cancer 2016 16:559
    Content type: Research article Published on:

  13. Gynecologic cancer is one of the most common malignant diseases in working-age women. This study investigated whether several characteristics influence return to work after treatment of gynecologic cancer.

    Authors: Keiichiro Nakamura, Hisashi Masuyama, Takeshi Nishida, Junko Haraga, Naoyuki Ida, Masayuki Saijo, Tomoko Haruma, Tomoyuki Kusumoto, Noriko Seki and Yuji Hiramatsu
    Citation: BMC Cancer 2016 16:558
    Content type: Research article Published on:

  14. Little is known about the relationship between preoperative body mass index and need for adjuvant radiation therapy (RT) following radical prostatectomy. The goal of this study was to evaluate the utility of b...

    Authors: Kosj Yamoah, Charnita M. Zeigler-Johnson, Abra Jeffers, Bruce Malkowicz, Elaine Spangler, Jong Y. Park, Alice Whittemore and Timothy R. Rebbeck
    Citation: BMC Cancer 2016 16:557
    Content type: Research article Published on:

  15. Diffusion Weighted (DW) Magnetic Resonance Imaging (MRI) has been studed in several cancers including cervical cancer. This study was designed to investigate the association of DW-MRI parameters with baseline ...

    Authors: Daniel Grossi Marconi, Jose Humberto Tavares Guerreiro Fregnani, Rodrigo Ribeiro Rossini, Ana Karina Borges Junqueira Netto, Fabiano Rubião Lucchesi, Audrey Tieko Tsunoda and Mitchell Kamrava
    Citation: BMC Cancer 2016 16:556
    Content type: Research article Published on:

  16. Lymph node (LN) status is the most important prognostic variable used to guide ER positive (+) breast cancer treatment. While a positive nodal status is traditionally associated with a poor prognosis, a subset...

    Authors: Jessica G. Cockburn, Robin M. Hallett, Amy E. Gillgrass, Kay N. Dias, T. Whelan, M. N. Levine, John A. Hassell and Anita Bane
    Citation: BMC Cancer 2016 16:555
    Content type: Research article Published on:

  17. The distinction between right-sided and left-sided colon cancer has recently received considerable attention due to differences regarding underlying genetic mutations. There is an ongoing debate if right- vers...

    Authors: Rene Warschkow, Michael C. Sulz, Lukas Marti, Ignazio Tarantino, Bruno M. Schmied, Thomas Cerny and Ulrich Güller
    Citation: BMC Cancer 2016 16:554
    Content type: Research article Published on:

  18. Many urothelial carcinomas (UC) contain activating PIK3CA mutations. In telomerase-immortalized normal urothelial cells (TERT-NHUC), ectopic expression of mutant PIK3CA induces PI3K pathway activation, cell proli...

    Authors: R. L. Ross, H. R. McPherson, L. Kettlewell, S. D. Shnyder, C. D. Hurst, O. Alder and M. A. Knowles
    Citation: BMC Cancer 2016 16:553
    Content type: Research article Published on:

  19. Despite aggressive regimens, the clinical outcome of head and neck squamous cell carcinoma remains poor. The detection of circulating tumor cells could potentially improve the management of patients with disse...

    Authors: Xianglei Wu, Romina Mastronicola, Qian Tu, Gilbert Charles Faure, Marcelo De Carvalho Bittencourt and Gilles Dolivet
    Citation: BMC Cancer 2016 16:552
    Content type: Case report Published on:

  21. Platinum resistance is a major obstacle in the treatment of epithelial ovarian cancer (EOC). Activation of the AKT pathway promotes platinum resistance while inhibition of AKT sensitizes chemoresistant cells. ...

    Authors: Margaret E. Whicker, Z. Ping Lin, Ruth Hanna, Alan C. Sartorelli and Elena S. Ratner
    Citation: BMC Cancer 2016 16:550
    Content type: Research article Published on:

  22. The purpose of this study was to evaluate invasive and metastatic potential of urothelial cancer by investigating differential expression of various clock genes/proteins participating in the 24 h circadian rhy...

    Authors: Jorunn Litlekalsoy, Kari Rostad, Karl-Henning Kalland, Jens G. Hostmark and Ole Didrik Laerum
    Citation: BMC Cancer 2016 16:549
    Content type: Research article Published on:

  23. The cancer stem cells (CSCs), a small subpopulation of cells in tumor are responsible for the tumor initiation, growth, recurrence and metastasis of cancer, as well as resistance of cancers to drugs or radioth...

    Authors: Koji Harada, Tarannum Ferdous, Dan Cui, Yasuhiro Kuramitsu, Takuya Matsumoto, Eiji Ikeda, Hideyuki Okano and Yoshiya Ueyama
    Citation: BMC Cancer 2016 16:548
    Content type: Research article Published on:

  24. Circulating tumour cells (CTCs) have been found to be a prognostic marker for reduced disease free survival, breast cancer–specific survival, and overall survival before the start of systemic treatment.

    Authors: Theresa Vilsmaier, Brigitte Rack, Wolfgang Janni, Udo Jeschke and Tobias Weissenbacher
    Citation: BMC Cancer 2016 16:547
    Content type: Research article Published on:

  25. Long-term prognostic significance of loss of heterozygosity on chromosome 9p21 for localized renal cell carcinoma following surgery remains unreported. The study assessed the frequency of deletions of differen...

    Authors: Ismail El-Mokadem, Alison Lim, Thomas Kidd, Katherine Garret, Norman Pratt, David Batty, Stewart Fleming and Ghulam Nabi
    Citation: BMC Cancer 2016 16:546
    Content type: Research article Published on:

  26. Directly targeting therapeutic suicide gene to a solid tumor is a hopeful approach for cancer gene therapy. Treatment of a solid tumor by an effective vector for a suicide gene remains a challenge. Given the l...

    Authors: Changdong Wang, Yongping Ma, Qiongwen Hu, Tingting Xie, Jiayan Wu, Fan Zeng and Fangzhou Song
    Citation: BMC Cancer 2016 16:545
    Content type: Research article Published on:

  27. Work is a central resource for cancer survivors as it not only provides income but also impacts health and quality of life. Additionally, work helps survivors to cope with the perceived critical life event. Th...

    Authors: Julian Wienert, Betje Schwarz and Matthias Bethge
    Citation: BMC Cancer 2016 16:544
    Content type: Study protocol Published on:

  28. Sorafenib is the standard first-line therapy for hepatocellular carcinoma (HCC) and probably ectopic hepatocellular carcinoma (EHCC) as well. No report involves a side effect of delayed high fever of sorafenib...

    Authors: Tianxiang Cui, Xinwei Diao, Xiewan Chen, Shaojiang Huang and Jianguo Sun
    Citation: BMC Cancer 2016 16:543
    Content type: Case report Published on:

  29. Ganglioneuroma (GN) and ganglioneuroblastoma intermixed (GNBI) are mature variants of neuroblastic tumors (NT). It is still discussed whether incomplete resection of GN/GNBI impairs the outcome of patients.

    Authors: Boris Decarolis, Thorsten Simon, Barbara Krug, Ivo Leuschner, Christian Vokuhl, Peter Kaatsch, Dietrich von Schweinitz, Thomas Klingebiel, Ingo Mueller, Lothar Schweigerer, Frank Berthold and Barbara Hero
    Citation: BMC Cancer 2016 16:542
    Content type: Research article Published on:

  31. Triple-negative breast cancer (TNBC) is an aggressive histological subtype with limited treatment options and very poor prognosis following progression after standard chemotherapeutic regimens. Therefore, nove...

    Authors: Huda A. Al-Howail, Hana A. Hakami, Basem Al-Otaibi, Amer Al-Mazrou, Maha H. Daghestani, Ibrahim Al-Jammaz, Huda H. Al-Khalaf and Abdelilah Aboussekhra
    Citation: BMC Cancer 2016 16:540
    Content type: Research article Published on:

  32. Despite the clinical significance of liver metastases, the difference between molecular and cellular changes in primary colorectal cancers (CRC) and matched liver metastases is poorly understood.

    Authors: Ja-Rang Lee, Chae Hwa Kwon, Yuri Choi, Hye Ji Park, Hyun Sung Kim, Hong-Jae Jo, Nahmgun Oh and Do Youn Park
    Citation: BMC Cancer 2016 16:539
    Content type: Research article Published on:

  34. The efficacy and safety of rituximab-based chemotherapy (R-chemo), the standard regimen for patients with diffuse large B-cell lymphoma (DLBCL), which is more common in Asia than in Western countries, are well...

    Authors: Jianqiu Wu, Yongping Song, Liping Su, Li Xu, Tingchao Chen, Zhiyun Zhao, Mingzhi Zhang, Wei Li, Yu Hu, Xiaohong Zhang, Yuhuan Gao, Zuoxing Niu, Ru Feng, Wei Wang, Jiewen Peng, Xiaolin Li…
    Citation: BMC Cancer 2016 16:537
    Content type: Research article Published on:

  35. The increasingly complex programs of contemporary cancer therapy emphasize the need for biological indicators of both therapeutic response and adverse effects. One example is combined-modality treatment aimed ...

    Authors: Erta Kalanxhi, Helga Helseth Hektoen, Sebastian Meltzer, Svein Dueland, Kjersti Flatmark and Anne Hansen Ree
    Citation: BMC Cancer 2016 16:536
    Content type: Research article Published on:

  36. Colorectal cancer (CRC) is one of the most common malignancies and a leading cause of cancer death worldwide. Most cancer cells display high rates of glycolysis with production of lactic acid, which is then ex...

    Authors: Sandra Fernandes Martins, Ricardo Amorim, Marta Viana-Pereira, Céline Pinheiro, Ricardo Filipe Alves Costa, Patrícia Silva, Carla Couto, Sara Alves, Sara Fernandes, Sónia Vilaça, Joaquim Falcão, Herlander Marques, Fernando Pardal, Mesquita Rodrigues, Ana Preto, Rui Manuel Reis…
    Citation: BMC Cancer 2016 16:535
    Content type: Research article Published on:

  37. Due to the steadily increasing number of cancer patients worldwide the early diagnosis and treatment of cancer is a major field of research. The diagnosis of cancer is mostly performed by an experienced pathol...

    Authors: Thomas W. Bocklitz, Firas Subhi Salah, Nadine Vogler, Sandro Heuke, Olga Chernavskaia, Carsten Schmidt, Maximilian J. Waldner, Florian R. Greten, Rolf Bräuer, Michael Schmitt, Andreas Stallmach, Iver Petersen and Jürgen Popp
    Citation: BMC Cancer 2016 16:534
    Content type: Research Article Published on:

  38. Preclinical research indicate that vascular disrupting agent (VDA) treatment induces extensive tumor death but also a systemic mobilization of bone marrow derived cells including endothelial progenitor cells (...

    Authors: Linh Nguyen, Theodora Fifis and Christopher Christophi
    Citation: BMC Cancer 2016 16:533
    Content type: Research article Published on:

  39. Saikosaponin d (SSd) is one of the main active triterpene saponins in Bupleurum falcatum. It has a steroid-like structure, and is reported to have pharmacological activities, including liver protection in rat, ce...

    Authors: Ming-Feng Chen, S. Joseph Huang, Chao-Cheng Huang, Pei-Shan Liu, Kun-I Lin, Ching-Wen Liu, Wen-Chuan Hsieh, Li-Yen Shiu and Chang-Han Chen
    Citation: BMC Cancer 2016 16:532
    Content type: Research article Published on:

  40. The use of targeted agents to impel dual inhibition of anti-apoptotic mechanisms and mTOR-mediated pro-survival signaling in colorectal carcinoma (CRC) cell lines with KRAS or BRAF mutation has been shown to indu...

    Authors: Karianne Risberg, Kathrine Røe Redalen, Linda Sønstevold, Tonje Bjørnetrø, Janne Sølvernes and Anne Hansen Ree
    Citation: BMC Cancer 2016 16:531
    Content type: Research article Published on:

  41. Forkhead Box P3 (Foxp3) is a regulatory T cells marker, and its expression correlates with prognosis in a number of malignancies. The aim of this study is to determine the relationship of Foxp3 expression with...

    Authors: Jing-Jing Song, Si-Jia Zhao, Juan Fang, Da Ma, Xiang-Qi Liu, Xiao-Bing Chen, Yun Wang, Bin Cheng and Zhi Wang
    Citation: BMC Cancer 2016 16:530
    Content type: Research article Published on:

  42. Prostate cancer (PC) is a major health concern for men worldwide, with an estimated lifetime risk of ~14 %. A recent comprehensive analysis of mutational processes revealed ageing and mismatch repair as the on...

    Authors: Lynne Kerr, Matthew J. Rewhorn, Mark Longmuir, Sioban Fraser, Shaun Walsh, Nicola Andrew and Hing Y. Leung
    Citation: BMC Cancer 2016 16:529
    Content type: Research article Published on:

  43. Adequate prediction of survival plays an important role in treatment decisions for patients with spinal bone metastases (SBM). Several prognostic factors are already used in daily clinical practice, but factor...

    Authors: Robert J. Wolf, Robert Foerster, Thomas Bruckner, Tilman Bostel, Ingmar Schlampp, Juergen Debus, Harald Rief and German Bone Research Group
    Citation: BMC Cancer 2016 16:528
    Content type: Research article Published on:

  44. One of the most prevalent long-term consequences of surviving breast cancer is fear of cancer recurrence (FCR), which is associated with higher (mental) healthcare costs and lower surveillance rates. The major...

    Authors: Sanne Jasperine van Helmondt, Marije Liesbeth van der Lee and Jolanda de Vries
    Citation: BMC Cancer 2016 16:527
    Content type: Study protocol Published on:

  45. Binding to Sema4D and PlexinB1 induce angiogenesis and invasive growth in colorectal cancer (CRC). The expression of Semaphorin4D (Sema4D) and PlexinB1 has been shown to be related to the prognosis of patients...

    Authors: Tetsuro Ikeya, Kiyoshi Maeda, Hisashi Nagahara, Masatsune Shibutani, Yasuhito Iseki and Kosei Hirakawa
    Citation: BMC Cancer 2016 16:525
    Content type: Research article Published on:

  46. Success of cancer prodrugs relying on a foreign gene requires specific delivery of the gene to the cancer, and improvements such as higher level gene transfer and expression. Attaining these objectives will be...

    Authors: Jing-Hung Wang, Aaron N. Endsley, Carol E. Green and A. C. Matin
    Citation: BMC Cancer 2016 16:524
    Content type: Research article Published on:

  47. Pharmacokinetic guided dosing of 5-fluorouracil chemotherapies to bring plasma 5-fluorouracil into a desired therapeutic range may lead to fewer side effects and better patient outcomes. High performance liqui...

    Authors: Karoline Freeman, Mark P. Saunders, Olalekan A. Uthman, Sian Taylor-Phillips, Martin Connock, Rachel Court, Tara Gurung, Paul Sutcliffe and Aileen Clarke
    Citation: BMC Cancer 2016 16:523
    Content type: Research article Published on:

  48. The expression of HER2, estrogen (ER) and progesterone (PR) receptor can change during the course of the disease in breast cancer (BC). Therefore, reassessment of these markers at the time of disease progressi...

    Authors: Bahriye Aktas, Sabine Kasimir-Bauer, Volkmar Müller, Wolfgang Janni, Tanja Fehm, Diethelm Wallwiener, Klaus Pantel and Mitra Tewes
    Citation: BMC Cancer 2016 16:522
    Content type: Research article Published on:

  49. Neoadjuvant chemoradiotherapy (NACRT) followed by surgical resection is the standard therapy for locally advanced rectal cancer. However, tumor response following NACRT varies, ranging from pathologic complete...

    Authors: Laura del Puerto-Nevado, Juan Pablo Marin-Arango, Maria Jesus Fernandez-Aceñero, David Arroyo-Manzano, Javier Martinez-Useros, Aurea Borrero-Palacios, Maria Rodriguez-Remirez, Arancha Cebrian, Teresa Gomez del Pulgar, Marlid Cruz-Ramos, Cristina Carames, Begoña Lopez-Botet and Jesús Garcia-Foncillas
    Citation: BMC Cancer 2016 16:519
    Content type: Research article Published on:

  50. Authors: Antoine Adenis, Christelle de la Fouchardiere, Bernard Paule, Pascal Burtin, David Tougeron, Jennifer Wallet, Louis-Marie Dourthe, Pierre-Luc Etienne, Laurent Mineur, Stéphanie Clisant, Jean-Marc Phelip, Andrew Kramar and Thierry Andre
    Citation: BMC Cancer 2016 16:518
    Content type: Erratum Published on:

    The original article was published in BMC Cancer 2016 16:412

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