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  1. The purpose of this study was to investigate the impact of the Controlling Nutritional Status (CONUT) score on survival compared with the platelet to lymphocyte ratio (PLR), the neutrophil to lymphocyte ratio ...

    Authors: Takahiro Toyokawa, Naoshi Kubo, Tatsuro Tamura, Katsunobu Sakurai, Ryosuke Amano, Hiroaki Tanaka, Kazuya Muguruma, Masakazu Yashiro, Kosei Hirakawa and Masaichi Ohira
    Citation: BMC Cancer 2016 16:722
    Content type: Research article Published on:

  2. We hypothesized that pretreatment serum levels of insulin and other serum markers would predict Progression-free survival (PFS), defined as time to castration-resistant progression or death, in metastatic andr...

    Authors: Farshid Dayyani, Amado J. Zurita, Graciela M. Nogueras-González, Rebecca Slack, Randall E. Millikan, John C. Araujo, Gary E. Gallick, Christopher J. Logothetis and Paul G. Corn
    Citation: BMC Cancer 2016 16:721
    Content type: Research article Published on:

  3. Radioresistance is one of the major factors limiting the therapeutic efficacy and prognosis of patients with nasopharyngeal carcinoma (NPC). Accumulating evidence has suggested that aberrant expression of long...

    Authors: Guo Li, Yong Liu, Chao Liu, Zhongwu Su, Shuling Ren, Yunyun Wang, Tengbo Deng, Donghai Huang, Yongquan Tian and Yuanzheng Qiu
    Citation: BMC Cancer 2016 16:719
    Content type: Research article Published on:

  4. Desmoplastic malignant pleural mesothelioma (DMM) is rare histological subtype of diffuse malignant pleural mesothelioma (MPM), accounting for 5–10 % of cases. It has a poor prognosis, with direct invasion of ...

    Authors: Kana Hashimoto, Yusuke Okuma, Yukio Hosomi and Tsunekazu Hishima
    Citation: BMC Cancer 2016 16:718
    Content type: Case report Published on:

  5. Although radiotherapy following mastectomy was demonstrated to reduce the recurring risk and improve the prognosis of patients with breast cancer, it is also notorious for comprehensive side effects, hence onl...

    Authors: Li Min, Cheng Zhang, Ruolan Ma, Xiaofan Li, Hua Yuan, Yihao Li, Ruxuan Chen, Caiyun Liu, Jianping Guo, Like Qu and Chengchao Shou
    Citation: BMC Cancer 2016 16:717
    Content type: Research article Published on:

  6. Human anion exchanger 1 and 2 (AE1 and AE2) mediate the exchange of Cl−/HCO3 − across the plasma membrane and regulate intracellular pH (pHi). AE1 is specifically expressed on the surfa...

    Authors: Ting Wang, Hong-Jun Fei, Ye Yang, Xiao-Shu Jiang, Min Yan, Zhi Zeng, Jun Wu, Ling-Jun Song, Hua Tian and Guo-Hui Fu
    Citation: BMC Cancer 2016 16:716
    Content type: Research article Published on:

  7. The purpose of this study was to examine racial and socio-economic differences in the receipt of laparoscopic or open surgery among patients with colorectal cancer, and to determine if racial and socio-economi...

    Authors: Tomi Akinyemiju, Qingrui Meng and Neomi Vin-Raviv
    Citation: BMC Cancer 2016 16:715
    Content type: Research article Published on:

  8. The role of laparoscopic resection in patients with clinically suspicious T4 colorectal cancer remains controversial. The aim of this study was to compare the long-term and oncologic outcomes of laparoscopic r...

    Authors: Jong Seob Park, Jung Wook Huh, Yoon Ah Park, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee and Ho-Kyung Chun
    Citation: BMC Cancer 2016 16:714
    Content type: Research article Published on:

  9. Loss of Amylo-alpha-1-6-glucosidase-4-alpha-glucanotransferase (AGL) drives rapid proliferation of bladder cancer cells by upregulating Hyaluronic acid(HA) Synthase (HAS2) mediated HA synthesis. However the ro...

    Authors: Darby Oldenburg, Yuanbin Ru, Benjamin Weinhaus, Steve Cash, Dan Theodorescu and Sunny Guin
    Citation: BMC Cancer 2016 16:713
    Content type: Research article Published on:

  10. Response-guided neoadjuvant chemotherapy (RG-NACT) with magnetic resonance imaging (MRI) is effective in treating oestrogen receptor positive/human epidermal growth factor receptor-2 negative (ER-positive/HER2...

    Authors: Anna Miquel-Cases, Lotte M. G. Steuten, Lisanne S. Rigter and Wim H. van Harten
    Citation: BMC Cancer 2016 16:712
    Content type: Research article Published on:

  11. Accounting for patients’ perspective has become increasingly important. Based on the Consumer Quality Index method (founded on Consumer Assessment of Healthcare Providers and Systems) a questionnaire was recen...

    Authors: Anke Wind, Mark Patrick Roeling, Jana Heerink, Herman Sixma, Pietro Presti, Claudio Lombardo and Wim van Harten
    Citation: BMC Cancer 2016 16:711
    Content type: Research article Published on:

  12. In 2014 approximately 21,200 patients were diagnosed with oesophageal and gastric cancer in England and Wales, of whom 37 % underwent planned curative treatments. Potentially curative surgical resection is ass...

    Authors: M. A. West, L. Loughney, G. Ambler, B. D. Dimitrov, J. J. Kelly, M. G. Mythen, R. Sturgess, P. M. A. Calverley, A. Kendrick, M. P. W. Grocott and S. Jack
    Citation: BMC Cancer 2016 16:710
    Content type: Study protocol Published on:

  13. Pancreatic adenocarcinoma is an aggressive disease with poor prognosis. In a randomized phase III trial, combination of Nab-paclitaxel (Nab-P) plus gemcitabine showed superior activity and efficacy in first-li...

    Authors: Ferdinando De Vita, Jole Ventriglia, Antonio Febbraro, Maria Maddalena Laterza, Alessio Fabozzi, Beatrice Savastano, Angelica Petrillo, Anna Diana, Guido Giordano, Teresa Troiani, Giovanni Conzo, Gennaro Galizia, Fortunato Ciardiello and Michele Orditura
    Citation: BMC Cancer 2016 16:709
    Content type: Research article Published on:

  14. Neoadjuvant androgen deprivation therapy (ADT) has been suggested to confer several clinical benefits in patients with prostate cancer (PCa) undergoing transperineal prostate brachytherapy (TPPB). Unlike gonad...

    Authors: Kenta Miki, Hiroshi Sasaki, Masahito Kido, Hiroyuki Takahashi, Manabu Aoki and Shin Egawa
    Citation: BMC Cancer 2016 16:708
    Content type: Study protocol Published on:

  15. Baicalein is a widely used Chinese herbal medicine derived from Scutellaria baicalenesis, which has been traditionally used as anti-inflammatory and anti-cancer therapy. In this study we examined the anti-tumour ...

    Authors: Mary-Clare Cathcart, Zivile Useckaite, Clive Drakeford, Vikki Semik, Joanne Lysaght, Kathy Gately, Kenneth J. O’Byrne and Graham P. Pidgeon
    Citation: BMC Cancer 2016 16:707
    Content type: Research article Published on:

  16. We previously described several abnormally expressed long non-coding RNA (lncRNA) in tong squamous cell carcinomas (TSCCs) that might be associated with tumor progression. In the present study, we aimed to inv...

    Authors: Zhengyu Fang, Shanshan Zhang, Yufan Wang, Shiyue Shen, Feng Wang, Yinghua Hao, Yuxia Li, Bingyue Zhang, You Zhou and Hongyu Yang
    Citation: BMC Cancer 2016 16:706
    Content type: Research article Published on:

  17. Hepatocellular carcinoma (HCC) patients with hepatic vein tumor thrombosis (HVTT) extending to the inferior vena cava (IVC) have an extremely poor prognosis. Here we report a case of HCC with HVTT and renal dy...

    Authors: Atene Itoh, Hiroshi Sadamori, Kazuhisa Yabushita, Kazuteru Monden, Masashi Tatsukawa, Masayoshi Hioki, Tsuyoshi Hyodo, Kunihiro Omonishi, Toru Ueki, Satoshi Ohno, Kohsaku Sakaguchi and Norihisa Takakura
    Citation: BMC Cancer 2016 16:705
    Content type: Case report Published on:

  18. Non-muscle-invasive bladder cancer (NMIBC) is a high incidence form of bladder cancer (BCa), where genetic and epigenetic alterations occur frequently. We assessed the performance of associating a FGFR3 mutation ...

    Authors: Jean-Pierre Roperch, Bernard Grandchamp, François Desgrandchamps, Pierre Mongiat-Artus, Vincent Ravery, Idir Ouzaid, Morgan Roupret, Véronique Phe, Calin Ciofu, Florence Tubach, Olivier Cussenot and Roberto Incitti
    Citation: BMC Cancer 2016 16:704
    Content type: Research article Published on:

  19. The continual reassessment method (CRM) requires an underlying model of the dose-toxicity relationship (“prior skeleton”) and there is limited guidance of what this should be when little is known about this as...

    Authors: Gareth D. James, Stefan N. Symeonides, Jayne Marshall, Julia Young and Glen Clack
    Citation: BMC Cancer 2016 16:703
    Content type: Research article Published on:

  20. Iron is essential for cell replication, metabolism and growth. Because neoplastic cells have high iron requirements due to their rapid proliferation, iron depletion may be a novel therapeutic strategy for canc...

    Authors: Hirofumi Harima, Seiji Kaino, Taro Takami, Shuhei Shinoda, Toshihiko Matsumoto, Koichi Fujisawa, Naoki Yamamoto, Takahiro Yamasaki and Isao Sakaida
    Citation: BMC Cancer 2016 16:702
    Content type: Research article Published on:

  21. Hypoxia is a typical character of locally advanced solid tumours. The transcription factor hypoxia-inducible factor 1α (HIF-1α) is the main regulator under the hypoxic environment. HIF-1α regulates various gen...

    Authors: Seon-Ok Lee, Joo-Seok Kim, Myoung-Sun Lee and Hyo-Jeong Lee
    Citation: BMC Cancer 2016 16:701
    Content type: Research article Published on:

  22. In breast cancer, the epithelial to mesenchyme transition (EMT) is associated to tumour dissemination, drug resistance and high relapse risks. It is partly controlled by epigenetic modifications such as histon...

    Authors: Jean-Marc Gregoire, Laurence Fleury, Clara Salazar-Cardozo, Frédéric Alby, Véronique Masson, Paola Barbara Arimondo and Frédéric Ausseil
    Citation: BMC Cancer 2016 16:700
    Content type: Research article Published on:

  23. As a multi-targeted anti-angiogenic receptor tyrosine kinase (RTK) inhibitor sunitinib (SUN) has been established for renal cancer and gastrointestinal stromal tumors. In advanced refractory esophagogastric ca...

    Authors: Markus Moehler, Irina Gepfner-Tuma, Annett Maderer, Peter C. Thuss-Patience, Joern Ruessel, Susanna Hegewisch-Becker, Hansjochen Wilke, Salah-Eddin Al-Batran, Mohammad-Reza Rafiyan, Florian Weißinger, Hans-Joachim Schmoll, Frank Kullmann, Ludwig Fischer von Weikersthal, Jens T. Siveke, Jens Weusmann, Stephan Kanzler…
    Citation: BMC Cancer 2016 16:699
    Content type: Research article Published on:

  24. Breast cancer and its treatment-related adverse effects are harmful to physical, psychological, and social functioning, leading to health-related quality of life (HRQoL) impairment in patients. Many programs h...

    Authors: Kaina Zhou, Duolao Wang, Xiaole He, Lanting Huo, Jinghua An, Minjie Li, Wen Wang and Xiaomei Li
    Citation: BMC Cancer 2016 16:698
    Content type: Study protocol Published on:

  25. Human epidermal growth factor receptor-2 (HER2) is a transmembrane tyrosine kinase receptor that is overexpressed in 25 to 30 % of human breast cancers and is preferentially localized in lipid rafts. Stomatin ...

    Authors: Chin-Yau Chen, Chih-Yung Yang, Yen-Chung Chen, Chia-Wen Shih, Su-Shun Lo and Chi-Hung Lin
    Citation: BMC Cancer 2016 16:697
    Content type: Research article Published on:

  26. The Cancer Rehabilitation Evaluation System (CARES) is a quality of life (QOL) and needs assessment instrument of US origin that was developed in the 90’s. Since November 2012 the copyright and user fee were a...

    Authors: Bojoura Schouten, Johan Hellings, Elke Van Hoof, Patrick Vankrunkelsven, Paul Bulens, Frank Buntinx, Jeroen Mebis, Dominique Vandijck and Ward Schrooten
    Citation: BMC Cancer 2016 16:696
    Content type: Research article Published on:

  27. Pathologic complete response (pCR) after neoadjuvant chemotherapy for breast cancer is associated with improved prognosis in aggressive tumor subtypes, including ERBB2- positive tumors. Recent adoption of pCR ...

    Authors: Benjamin C. Calhoun, Bryce Portier, Zhen Wang, Eugen C. Minca, G. Thomas Budd, Christopher Lanigan, Raymond R. Tubbs and Larry E. Morrison
    Citation: BMC Cancer 2016 16:695
    Content type: Research article Published on:

  29. To date, no guideline is proposed for elderly nasopharyngeal carcinoma (NPC) due to lack of prospective clinical trials. The present study comparing the survivals and toxicities in elderly NPC patients receive...

    Authors: Qi Zeng, Jie Wang, Xing Lv, Jie Li, Li-Jie Yin, Yan-Qun Xiang and Xiang Guo
    Citation: BMC Cancer 2016 16:693
    Content type: Research article Published on:

  30. Next Generation Sequencing (NGS) has become a valuable tool for molecular landscape characterization of cancer genomes, leading to a better understanding of tumor onset and progression, and opening new avenues...

    Authors: Silvia Bonfiglio, Irene Vanni, Valeria Rossella, Anna Truini, Dejan Lazarevic, Maria Giovanna Dal Bello, Angela Alama, Marco Mora, Erika Rijavec, Carlo Genova, Davide Cittaro, Francesco Grossi and Simona Coco
    Citation: BMC Cancer 2016 16:692
    Content type: Research article Published on:

  32. No novel chemotherapeutic combinations have demonstrated superior efficacy to etoposide/cisplatin (EP), a standard treatment regimen for extensive-stage small cell lung carcinoma (ES-SCLC) over the past decade...

    Authors: In-Jae Oh, Kyu-Sik Kim, Cheol-Kyu Park, Young-Chul Kim, Kwan-Ho Lee, Jin-Hong Jeong, Sun-Young Kim, Jeong-Eun Lee, Kye-Chul Shin, Tae-Won Jang, Hyun-Kyung Lee, Kye-Young Lee and Sung-Yong Lee
    Citation: BMC Cancer 2016 16:690
    Content type: Research article Published on:

  33. Cisplatin-based treatment has been considered the standard treatment regimen of HNSCC. Cetuximab is an emerging target therapy that has potential therapeutic benefits over cisplatin. Nevertheless, curative eff...

    Authors: Jingwen Huang, Jing Zhang, Changle Shi, Lei Liu and Yuquan Wei
    Citation: BMC Cancer 2016 16:689
    Content type: Research article Published on:

  34. The management of ovarian cancer remains a challenge. Because of the lack of early symptoms, it is often diagnosed at a late stage when it is likely to have metastasized beyond ovaries. Currently, platinum bas...

    Authors: Zaynab Al-Eisawi, Philip Beale, Charles Chan, Jun Qing Yu, Nicholas Proschogo, Mark Molloy and Fazlul Huq
    Citation: BMC Cancer 2016 16:688
    Content type: Research article Published on:

  35. Forkhead box P3(FOXP3) is known as the optimum maker for regulatory T cells(Tregs), which are conventionally thought to induce immune tolerance to disturb the antitumor immunity. However, the research on the p...

    Authors: Jiafeng Shou, Zhigang Zhang, Yucheng Lai, Zhigang Chen and Jian Huang
    Citation: BMC Cancer 2016 16:687
    Content type: Research article Published on:

  36. The efficacy of the classical treatment modalities surgery and radiotherapy in the treatment of aggressive fibromatosis is presently disputed and there is a shift towards a more conservative approach. The aim ...

    Authors: Danique L.M. van Broekhoven, Dirk J. Grünhagenl, Thijs van Dalen, Frits van Coevorden, Han J. Bonenkamp, Lukas B. Been, Marc H.A. Bemelmans, Sander D.S. Dijkstra, Chiara Colombo, Alessandro Gronchi and Cornelis Verhoef
    Citation: BMC Cancer 2016 16:686
    Content type: Study protocol Published on:

  37. Oral tongue squamous cell carcinoma (OTSCC) is one of the most aggressive forms of head and neck/oral cancer (HNOC), and is a complex disease with extensive genetic and epigenetic defects, including microRNA d...

    Authors: Qianting He, Zujian Chen, Qian Dong, Leitao Zhang, Dan Chen, Aditi Patel, Ajay Koya, Xianghong Luan, Robert J. Cabay, Yang Dai, Anxun Wang and Xiaofeng Zhou
    Citation: BMC Cancer 2016 16:685
    Content type: Research article Published on:

  38. Dermatomyositis is an autoimmune myopathy characterized by proximal muscle weakness, muscle inflammation, and typical skin findings. It is a rare disease with an incidence of ~1/100 000. About 15–30 % of adult...

    Authors: Ondřej Kubeček, Tomáš Soukup, Adam Paulík and Jindřich Kopecký
    Citation: BMC Cancer 2016 16:684
    Content type: Case report Published on:

  39. The progression of colorectal cancer (CRC) involves recurrent amplifications/mutations in the epidermal growth factor receptor (EGFR) and downstream signal transducers of the Ras pathway, KRAS and BRAF. Whethe...

    Authors: Narendra Padhan, Torbjörn E. M. Nordling, Magnus Sundström, Peter Åkerud, Helgi Birgisson, Peter Nygren, Sven Nelander and Lena Claesson-Welsh
    Citation: BMC Cancer 2016 16:683
    Content type: Research article Published on:

  40. Insulin-like growth factors (IGF´s) play a crucial role in controlling cancer cell proliferation, differentiation and apoptosis. Exercise has been postulated as an effective intervention in improving cancer-re...

    Authors: José Francisco Meneses-Echávez, Emilio González Jiménez, Jacqueline Schmidt Río-Valle, Jorge Enrique Correa-Bautista, Mikel Izquierdo and Robinson Ramírez-Vélez
    Citation: BMC Cancer 2016 16:682
    Content type: Research article Published on:

  41. T-lymphoma invasion and metastasis-inducing protein 1 (Tiam1) has been implicated in tumor occurrence and progression. Recent studies have shown that high expression levels of Tiam1 protein appear to be associ...

    Authors: Zhenling Li, Qixiang Liu, Junjie Piao, Fenjian Hua, Jing Wang, Guang Jin, Zhenhua Lin and Yan Zhang
    Citation: BMC Cancer 2016 16:681
    Content type: Research article Published on:

  42. Galectin-7 (Gal-7) is negatively regulated in cervical cancer, and appears to be a link between the apoptotic response triggered by cancer and the anti-tumoral activity of the immune system. Our understanding ...

    Authors: Juan Carlos Higareda-Almaraz, Juan S. Ruiz-Moreno, Jana Klimentova, Daniela Barbieri, Raquel Salvador-Gallego, Regina Ly, Ilse A. Valtierra-Gutierrez, Christiane Dinsart, Gabriel A. Rabinovich, Jiri Stulik, Frank Rösl and Bladimiro Rincon-Orozco
    Citation: BMC Cancer 2016 16:680
    Content type: Research article Published on:

  43. While hypothyroidism has frequently been reported with the use of TKIs, the thyroid-stimulating hormone (TSH) suppressing effect of TKIs is rare, except for thyroiditis. We describe a case with progressive rec...

    Authors: Juliette Eroukhmanoff, Frederic Castinetti, Nicolas Penel and Sebastien Salas
    Citation: BMC Cancer 2016 16:679
    Content type: Case report Published on:

  44. shRNA-mediated lethality screening is a useful tool to identify essential targets in cancer biology. Ovarian cancer (OC) is extremely heterogeneous and most cases are advanced stages at diagnosis. OC has a hig...

    Authors: Marianne K. Kim, Natasha Caplen, Sirisha Chakka, Lidia Hernandez, Carrie House, Georgios Pongas, Elizabeth Jordan and Christina M. Annunziata
    Citation: BMC Cancer 2016 16:678
    Content type: Research article Published on:

  45. Colorectal cancer (CRC) is the fourth most frequently diagnosed cancer and the second leading cause of neoplasm-related death in the United States. Several studies analyzed the efficacy of bevacizumab combined...

    Authors: Tobias Engel Ayer Botrel, Luciana Gontijo de Oliveira Clark, Luciano Paladini and Otávio Augusto C. Clark
    Citation: BMC Cancer 2016 16:677
    Content type: Research article Published on:

  46. Chromosome 3 amplification affecting the 3q26 region is a common genomic alteration in cervical cancer, typically marking the transition of precancerous intraepithelial lesions to an invasive phenotype. Though...

    Authors: Maximilian Linxweiler, Florian Bochen, Bernhard Schick, Silke Wemmert, Basel Al Kadah, Markus Greiner, Andrea Hasenfus, Rainer-Maria Bohle, Ingolf Juhasz-Böss, Erich-Franz Solomayer and Zoltan Ferenc Takacs
    Citation: BMC Cancer 2016 16:676
    Content type: Research article Published on:

  47. The aims of this study were to evaluate the impact of initial uterus-preserving surgery, such as myomectomy or subtotal hysterectomy, on the recurrence rates of patients with uterine sarcoma found incidentally...

    Authors: Jung-Yun Lee, Hyun Soo Kim, Eun Ji Nam, Sang Wun Kim, Sunghoon Kim and Young Tae Kim
    Citation: BMC Cancer 2016 16:675
    Content type: Research article Published on:

  48. Vitamin D receptor (VDR) gene polymorphisms affect the risk of prostate cancer. However, studies investigating the relationship between VDR gene polymorphisms (Cdx2 and ApaI) and prostate cancer risk are equivoca...

    Authors: Kewei Wang, Guosheng Wu, Jinping Li and Wentao Song
    Citation: BMC Cancer 2016 16:674
    Content type: Research article Published on:

  49. The Response Evaluation Criteria in Solid Tumors (RECIST) are the current standard for evaluating disease progression or therapy response in patients with solid tumors. RECIST 1.1 calls for axial, longest-diam...

    Authors: Kathleen E. Fenerty, Les R. Folio, Nicholas J. Patronas, Jennifer L. Marté, James L. Gulley and Christopher R. Heery
    Citation: BMC Cancer 2016 16:672
    Content type: Research article Published on:

  50. TBX3 is a T-box transcription factor repressor that is elevated in metastatic breast cancer and is believed to promote malignancy of tumor cells, possibly by promoting cell survival and epithelial-mesenchymal ...

    Authors: Milica Krstic, Connor D. Macmillan, Hon S. Leong, Allen G. Clifford, Lesley H. Souter, David W. Dales, Carl O. Postenka, Ann F. Chambers and Alan B. Tuck
    Citation: BMC Cancer 2016 16:671
    Content type: Research article Published on:

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