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  1. Nearly 30% of clear cell renal cell carcinoma (ccRCC) patients present with metastasis at the time of diagnosis, and the prognosis for these patients is poor. Therefore, novel potential prognostic biomarkers a...

    Authors: Yi Xu, Yanyue Tong, Jianyong Zhu, Zhangming Lei, Lijun Wan, Xiuwen Zhu, Feng Ye and Liping Xie
    Citation: BMC Cancer 2017 17:373
    Content type: Research article Published on:

  2. Renal cell carcinoma (RCC) is a tumor with immunogenic properties. Soluble interleukin-2 receptor (sIL-2R) has a role in T cell activation and may be important for immune regulation in various conditions, incl...

    Authors: Akinori Nukui, Akinori Masuda, Hideyuki Abe, Kyoko Arai, Ken-Ichiro Yoshida and Takao Kamai
    Citation: BMC Cancer 2017 17:372
    Content type: Research article Published on:

  3. Hurthle cell carcinoma makes up 3 to 5% of all thyroid cancers and is considered to be a true rarity. The aim of our study was to analyze clinical characteristics and survival rates of patients with Hurthle ce...

    Authors: Branisav Oluic, Ivan Paunovic, Zlatibor Loncar, Vladimir Djukic, Aleksandar Diklic, Milan Jovanovic, Zeljko Garabinovic, Nikola Slijepcevic, Branislav Rovcanin, Dusan Micic, Aleksandar Filipovic and Vladan Zivaljevic
    Citation: BMC Cancer 2017 17:371
    Content type: Research article Published on:

  5. The 3rd isoform of the metallothionein (MT3) gene family has been shown to be overexpressed in most ductal breast cancers. A previous study has shown that the stable transfection of MCF-7 cells with the MT3 ge...

    Authors: Brent Voels, Liping Wang, Donald A. Sens, Scott H. Garrett, Ke Zhang and Seema Somji
    Citation: BMC Cancer 2017 17:369
    Content type: Research article Published on:

  6. Gastric hepatoid adenocarcinoma (GHAC) is an atypical form of gastric cancer (GC) that has similar tissue morphology to hepatocellular carcinoma and frequently produces alpha-fetoprotein. We present an exceedi...

    Authors: Junichi Yoshizawa, Satoshi Ishizone, Meguru Ikeyama and Jun Nakayama
    Citation: BMC Cancer 2017 17:368
    Content type: Case report Published on:

  7. Prostate cancer (PCa) is characterized by clinical and biological heterogeneity and has differential outcomes and mortality rates. Therefore, it is necessary to identify molecular alterations to define new the...

    Authors: Caterina Mancarella, Irene Casanova-Salas, Ana Calatrava, Maria García-Flores, Cecilia Garofalo, Andrea Grilli, José Rubio-Briones, Katia Scotlandi and José Antonio López-Guerrero
    Citation: BMC Cancer 2017 17:367
    Content type: Research article Published on:

  8. The existence of cancer stem cells (CSCs) within a tumor bulk has been demonstrated for many solid tumors including epithelial ovarian carcinoma (EOC). CSCs have been associated to tumor invasion, metastasis a...

    Authors: Laura Zanotti, Chiara Romani, Laura Tassone, Paola Todeschini, Renata Alessandra Tassi, Elisabetta Bandiera, Giovanna Damia, Francesca Ricci, Laura Ardighieri, Stefano Calza, Sergio Marchini, Luca Beltrame, Germana Tognon, Maurizio D’Incalci, Sergio Pecorelli, Enrico Sartori…
    Citation: BMC Cancer 2017 17:366
    Content type: Research article Published on:

  9. Patients with upper gastrointestinal malignancy often require admission to hospital with dysphagia or jaundice requiring therapeutic endoscopy. Endoscopic intervention is often effective permitting rapid disch...

    Authors: R Singer, P Campbell, C Fernandes, P Statham, D Hochhauser and J Bridgewater
    Citation: BMC Cancer 2017 17:365
    Content type: Research article Published on:

  10. The obesity and lipid metabolism were previously proposed to be related with the clinical outcomes of metastatic renal cell carcinoma (mRCC). We tried to investigate the relationship between preoperative chole...

    Authors: Hakmin Lee, Yong June Kim, Eu Chang Hwang, Seok Ho Kang, Sung-Hoo Hong, Jinsoo Chung, Tae Gyun Kwon, Cheol Kwak, Hyeon Hoe Kim, Jong Jin Oh, Sang Chul Lee, Sung Kyu Hong, Sang Eun Lee and Seok-Soo Byun
    Citation: BMC Cancer 2017 17:364
    Content type: Research article Published on:

  11. A large number of chromosomal translocations of the human KMT2A gene, better known as the MLL gene, have so far been characterized. Genetic rearrangements involving KMT2A gene are frequently involved in lymphoid,...

    Authors: Estelle Menu, Nathalie Beaufils, Fabrice Usseglio, Estelle Balducci, Marina Lafage Pochitaloff, Regis Costello and Jean Gabert
    Citation: BMC Cancer 2017 17:363
    Content type: Case report Published on:

  12. Breast cancer is the leading cause of cancer morbidity among Shanghai and Hong Kong women, which contributes to 20–25% of new female cancer incidents. This study aimed to describe the temporal trend of breast ...

    Authors: Feng Wang, Lap Ah Tse, Wing-cheong Chan, Carol Chi-hei Kwok, Siu-lan Leung, Cherry Wu, Oscar Wai-kong Mang, Roger Kai-cheong Ngan, Mengjie Li, Wai-cho Yu, Koon-ho Tsang, Sze-hong Law, Xiaoping Miao, Chunxiao Wu, Ying Zheng, Fan Wu…
    Citation: BMC Cancer 2017 17:362
    Content type: Research article Published on:

  13. The impact of local tumor ablative therapy in oligometastasized prostate cancer (PC) is still under debate. To gain data for this approach, we evaluated oligometastasized PC patients receiving stereotactic bod...

    Authors: Gregor Habl, Christoph Straube, Kilian Schiller, Marciana Nona Duma, Markus Oechsner, Kerstin A. Kessel, Matthias Eiber, Markus Schwaiger, Hubert Kübler, Jürgen E. Gschwend and Stephanie E. Combs
    Citation: BMC Cancer 2017 17:361
    Content type: Research article Published on:

  14. Endonuclease domain containing 1 (ENDOD1) is implicated in tumorigenesis and aggressiveness of multiple tumors. In this study, we aimed to investigate the role of ENDOD1 in prostate cancer (PCa).

    Authors: Jianguang Qiu, Shubin Peng, Jie Si-Tu, Cheng Hu, Wentao Huang, Yunhua Mao, Wenhan Qiu, Ke Li and Dejuan Wang
    Citation: BMC Cancer 2017 17:360
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2017 17:569

  15. The addition of rituximab (R) to CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) -like therapy has improved survival in primary mediastinal B-cell lymphoma (PMBCL) patients. However, these res...

    Authors: K. Lisenko, G. Dingeldein, M. Cremer, M. Kriegsmann, A. D. Ho, M. Rieger and M. Witzens-Harig
    Citation: BMC Cancer 2017 17:359
    Content type: Research article Published on:

  16. The detection of somatic mutations in primary tumors is critical for the understanding of cancer evolution and targeting therapy. Multiple technologies have been developed to enable the detection of such mutat...

    Authors: Agus Darwanto, Anne-Mette Hein, Sascha Strauss, Yi Kong, Andrew Sheridan, Dan Richards, Eric Lader, Monika Ngowe, Timothy Pelletier, Danielle Adams, Austin Ricker, Nishit Patel, Andreas Kühne, Simon Hughes, Dan Shiffman, Dirk Zimmermann…
    Citation: BMC Cancer 2017 17:358
    Content type: Research article Published on:

  17. Malignant melanoma (MM) is one of the high degree of malignancy and early prone to blood and lymph node metastasis. There is not cured for MM. Tan II A has been reported to reduce cancer cell proliferation. Bu...

    Authors: Xiaojing Li, Zhifeng Li, Xianping Li, Baoguo Liu and Zhijun Liu
    Citation: BMC Cancer 2017 17:357
    Content type: Research article Published on:

  18. IKKε is an oncogenic kinase that was found amplified and overexpressed in a substantial percentage of human breast cancer cell lines and primary tumors using genomic and gene expression analyses. Molecular stu...

    Authors: Virginie Williams, Andrée-Anne Grosset, Natalia Zamorano Cuervo, Yves St-Pierre, Marie-Pierre Sylvestre, Louis Gaboury and Nathalie Grandvaux
    Citation: BMC Cancer 2017 17:356
    Content type: Research article Published on:

  19. Axitinib is used after failure of first line treatment for metastatic renal cell carcinoma (mRCC). A known side effect is the increase of haemoglobin level (HbL) during treatment with a suspected correlation w...

    Authors: Alison C. Johnson, Margarida Matias, Helen Boyle, Bernard Escudier, Alicia Molinier, Brigitte Laguerre, Carole Helissey, Pierre-Emmanuel Brachet, Audrey Emmanuelle Dugué, Loic Mourey, Elodie Coquan and Florence Joly
    Citation: BMC Cancer 2017 17:355
    Content type: Research article Published on:

  20. The Ki67 labeling index (LI) is regarded as a significant prognostic marker in ER-positive/HER2-negative breast cancer patients. The expression of PgR has recently been identified as another prognostic marker....

    Authors: Sasagu Kurozumi, Hiroshi Matsumoto, Yuji Hayashi, Katsunori Tozuka, Kenichi Inoue, Jun Horiguchi, Izumi Takeyoshi, Tetsunari Oyama and Masafumi Kurosumi
    Citation: BMC Cancer 2017 17:354
    Content type: Research article Published on:

  21. Authors: Makito Miyake, Yosuke Morizawa, Shunta Hori, Nagaaki Marugami, Keiji Shimada, Daisuke Gotoh, Yoshihiro Tatsumi, Yasushi Nakai, Takeshi Inoue, Satoshi Anai, Kazumasa Torimoto, Katsuya Aoki, Nobumichi Tanaka and Kiyohide Fujimoto
    Citation: BMC Cancer 2017 17:353
    Content type: Erratum Published on:

    The original article was published in BMC Cancer 2017 17:237

  23. Although Asian population was recognized to have a lower risk of venous thromboembolism (VTE), its increasing prevalence and incidence remain unclear in patients with malignancies. We attempted to predict VTE ...

    Authors: Hiromitsu Kitayama, Tomohiro Kondo, Junko Sugiyama, Kazutomo Kurimoto, Yasuhiro Nishino, Michiaki Hirayama and Yasushi Tsuji
    Citation: BMC Cancer 2017 17:351
    Content type: Research article Published on:

  24. Urokinase plasminogen activator (uPA) receptor (uPAR) is up-regulated at the invasive tumour front of human oral squamous cell carcinoma (OSCC), indicating a role for uPAR in tumour progression. We previously ...

    Authors: Synnove Norvoll Magnussen, Elin Hadler-Olsen, Daniela Elena Costea, Eli Berg, Cristiane Cavalcanti Jacobsen, Bente Mortensen, Tuula Salo, Inigo Martinez-Zubiaurre, Jan-Olof Winberg, Lars Uhlin-Hansen and Gunbjorg Svineng
    Citation: BMC Cancer 2017 17:350
    Content type: Research article Published on:

  26. Continued smoking after cancer adversely affects quality of life and survival, but one fifth of cancer survivors still smoke. Despite its demands, cancer presents an opportunity for positive behaviour change. ...

    Authors: Mary Wells, Patricia Aitchison, Fiona Harris, Gozde Ozakinci, Andrew Radley, Linda Bauld, Vikki Entwistle, Alastair Munro, Sally Haw, Bill Culbard and Brian Williams
    Citation: BMC Cancer 2017 17:348
    Content type: Research article Published on:

  27. Anxiety and depression can be a long-term strain in cancer survivors. Little is known about the emotional situation of cancer survivors who have to deal with work- and family-related issues. The purpose of thi...

    Authors: Laura Inhestern, Volker Beierlein, Johanna Christine Bultmann, Birgit Möller, Georg Romer, Uwe Koch and Corinna Bergelt
    Citation: BMC Cancer 2017 17:347
    Content type: Research article Published on:

  28. Fertility and pregnancy issues are of key importance for young breast cancer patients. Despite several advances in the field, there are still multiple unmet needs and barriers in discussing and dealing with th...

    Authors: Matteo Lambertini, Paola Anserini, Valeria Fontana, Francesca Poggio, Giuseppina Iacono, Annalisa Abate, Alessia Levaggi, Loredana Miglietta, Claudia Bighin, Sara Giraudi, Alessia D’Alonzo, Eva Blondeaux, Davide Buffi, Francesco Campone, Domenico F. Merlo and Lucia Del Mastro
    Citation: BMC Cancer 2017 17:346
    Content type: Study protocol Published on:

  29. The optimal extent of gastrectomy for middle-third gastric cancer remains controversial. In our study, the short-term effects and longer-term survival outcomes of distal subtotal gastrectomy and total gastrect...

    Authors: Xin Ji, Yan Yan, Zhao-De Bu, Zi-Yu Li, Ai-Wen Wu, Lian-Hai Zhang, Xiao-Jiang Wu, Xiang-Long Zong, Shuang-Xi Li, Fei Shan, Zi-Yu Jia and Jia-Fu Ji
    Citation: BMC Cancer 2017 17:345
    Content type: Research article Published on:

  31. Agricultural workers may be exposed to potential carcinogens including pesticides, sensitizing agents and solar radiation. Previous studies indicate increased risks of hematopoietic cancers and decreased risks...

    Authors: Linda Kachuri, M. Anne Harris, Jill S. MacLeod, Michael Tjepkema, Paul A. Peters and Paul A. Demers
    Citation: BMC Cancer 2017 17:343
    Content type: Research article Published on:

  32. Colorectal cancer (CRC) is the second leading cause of cancer-related death in men and women. Systemic disease with metastatic spread to distant sites such as the liver reduces the survival rate considerably. ...

    Authors: Derya Bocuk, Alexander Wolff, Petra Krause, Gabriela Salinas, Annalen Bleckmann, Christina Hackl, Tim Beissbarth and Sarah Koenig
    Citation: BMC Cancer 2017 17:342
    Content type: Research article Published on:

  33. Health benefits of the Mediterranean Diet (MD) have been shown in different at-risk populations. A German translation of the Mediterranean Diet Adherence Screener (MEDAS) from the PREvención con DIeta MEDiterr...

    Authors: Katrin Hebestreit, Maryam Yahiaoui-Doktor, Christoph Engel, Walter Vetter, Michael Siniatchkin, Nicole Erickson, Martin Halle, Marion Kiechle and Stephan C. Bischoff
    Citation: BMC Cancer 2017 17:341
    Content type: Research article Published on:

  34. There is inadequate evidence for the carcinogenicity of cobalt and cobalt compounds in humans. Consequently, the International Agency for Research on Cancer (IARC) has evaluated cobalt metal without tungsten c...

    Authors: Riitta Sauni, Panu Oksa, Jukka Uitti, Asko Linna, Raimo Kerttula and Eero Pukkala
    Citation: BMC Cancer 2017 17:340
    Content type: Research article Published on:

  35. Colorectal cancer is the third most commonly diagnosed malignancy and the fourth leading cause of cancer-related death globally. It is the second most common cancer among both males and females in Malaysia. Th...

    Authors: Bello Arkilla Magaji, Foong Ming Moy, April Camilla Roslani and Chee Wei Law
    Citation: BMC Cancer 2017 17:339
    Content type: Research article Published on:

  37. Providing an estimate of the percentage of cancer in Lebanon by 2018 that is due to the exposure to risk factors in 2008. Factors include: smoking, body mass index (BMI), physical inactivity, dietary factors, ...

    Authors: Maya A. Charafeddine, Sara H. Olson, Deborah Mukherji, Sally N. Temraz, Ghassan K. Abou-Alfa and Ali I. Shamseddine
    Citation: BMC Cancer 2017 17:337
    Content type: Research article Published on:

  38. Cosmetic result following breast conserving surgery (BCS) for cancer influences quality of life and psychosocial functioning in breast cancer patients. A preoperative prediction of expected cosmetic result fol...

    Authors: M. Lagendijk, E. L. Vos, A. H. J. Koning, M. G. M. Hunink, J. P. Pignol, E. M. L. Corten, C. de Monye, C. H. M. van Deurzen, J. H. van Dam, W. W. Vrijland, C. M. E. Contant, C. Verhoef, W. van Lankeren and L. B. Koppert
    Citation: BMC Cancer 2017 17:336
    Content type: Study protocol Published on:

  39. Lymphatic vessel density and lymphovascular invasion are commonly assessed to identify the clinicopathological outcomes in breast cancer. However, the prognostic values of them on patients’ survival are still ...

    Authors: Song Zhang, Dong Zhang, Mingfu Gong, Li Wen, Cuiwei Liao and Liguang Zou
    Citation: BMC Cancer 2017 17:335
    Content type: Research article Published on:

  40. The prognosis of synovial sarcoma (SS), an aggressive soft tissue sarcoma, remains poor. We previously reported that c-MET or platelet-derived growth factor receptor α (PDGFRα) signalling pathway is related to...

    Authors: Shutaro Yamada, Yoshinori Imura, Takaaki Nakai, Sho Nakai, Naohiro Yasuda, Keiko Kaneko, Hidetatsu Outani, Satoshi Takenaka, Kenichiro Hamada, Akira Myoui, Nobuhito Araki, Takafumi Ueda, Kazuyuki Itoh, Hideki Yoshikawa and Norifumi Naka
    Citation: BMC Cancer 2017 17:334
    Content type: Research article Published on:

  41. Blockade of the PD-1/PD-L1 immune checkpoint pathway is emerging as a promising immunotherapeutic approach for the management and treatment of head and neck cancer patients who do not respond to 1st/2nd line t...

    Authors: Arutha Kulasinghe, Chris Perry, Liz Kenny, Majid E. Warkiani, Colleen Nelson and Chamindie Punyadeera
    Citation: BMC Cancer 2017 17:333
    Content type: Case report Published on:

  42. In the primary analysis of the ERIVANCE BCC trial, vismodegib, the first US Food and Drug Administration–approved Hedgehog pathway inhibitor, showed objective response rates (ORRs) by independent review facili...

    Authors: Aleksandar Sekulic, Michael R. Migden, Nicole Basset-Seguin, Claus Garbe, Anja Gesierich, Christopher D. Lao, Chris Miller, Laurent Mortier, Dedee F. Murrell, Omid Hamid, Jorge F. Quevedo, Jeannie Hou, Edward McKenna, Natalie Dimier, Sarah Williams, Dirk Schadendorf…
    Citation: BMC Cancer 2017 17:332
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:366

  43. Mucinous appendiceal adenocarcinomas (AAs) are the most common histological subset of AAs. Nonmucinous AAs have been infrequently studied. We performed a single-center retrospective study to investigate this h...

    Authors: Marc Uemura, Wei Qiao, Keith Fournier, Jeffrey Morris, Paul Mansfield, Cathy Eng, Richard E Royal, Robert A Wolff, Kanwal Raghav, Gary N Mann and Michael J Overman
    Citation: BMC Cancer 2017 17:331
    Content type: Research article Published on:

  45. Breast cancer is the most globally diagnosed female cancer, with the triple negative breast cancer (TNBC) being the most aggressive subtype of the disease. In this study we aimed at comparing the effect of BRC...

    Authors: Danielle Bogan, Lucio Meile, Ahmed El Bastawisy, Hend F. Yousef, Abdel-Rahman N. Zekri, Abeer A. Bahnassy and Wael M. ElShamy
    Citation: BMC Cancer 2017 17:329
    Content type: Research article Published on:

  46. Genetic factors may influence an individual’s sensitivity to ionising radiation and therefore modify his/her risk of developing papillary thyroid carcinoma (PTC). Previously, we reported that common single nuc...

    Authors: Christine Lonjou, Francesca Damiola, Monika Moissonnier, Geoffroy Durand, Irina Malakhova, Vladimir Masyakin, Florence Le Calvez-Kelm, Elisabeth Cardis, Graham Byrnes, Ausrele Kesminiene and Fabienne Lesueur
    Citation: BMC Cancer 2017 17:328
    Content type: Research article Published on:

  47. Paraneoplastic acral vascular syndrome (PAVS) is a rare phenomenon which is observed in patients with adenocarcinomas and other malignancies. Various potential pathogenic mechanisms such as tumour invasion of ...

    Authors: Thilo Gambichler, Stefanie Strutzmann, Andrea Tannapfel and Laura Susok
    Citation: BMC Cancer 2017 17:327
    Content type: Case report Published on:

  48. Survival of childhood, adolescent and young adult (CAYA) cancers has increased with progress in the management of the treatments and has reached more than 80% at 5 years. Nevertheless, these survivors are at g...

    Authors: Charlotte Demoor-Goldschmidt, Delphine Drui, Isabelle Doutriaux, Gérard Michel, Pascal Auquier, Agnès Dumas, Claire Berger, Valérie Bernier, Sandrine Bohrer, Pierre-Yves Bondiau, Bruno Filhon, Brice Fresneau, Claire Freycon, Dinu Stefan, Sylvie Helfre, Angela Jackson…
    Citation: BMC Cancer 2017 17:326
    Content type: Study protocol Published on:

  49. Neoadjuvant fluoropirimidine (5FU)-based chemoradiotherapy (CRT) has been considered the standard of care for locally advanced rectal cancer (LARC). Whether addition of oxaliplatin (OXP) will further improve c...

    Authors: Francesca De Felice, Ilaria Benevento, Anna Lisa Magnante, Daniela Musio, Nadia Bulzonetti, Rossella Caiazzo and Vincenzo Tombolini
    Citation: BMC Cancer 2017 17:325
    Content type: Research article Published on:

  50. Metastasis of breast cancer displays site-specificity towards bone. Recently, studies have emerged indicating that primary tumors may remotely influence creation of a pre-metastatic niche. In this study, we us...

    Authors: Karis Chin-Quee and Henry J. Donahue
    Citation: BMC Cancer 2017 17:324
    Content type: Research article Published on:

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