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  1. There is limited data in Ghana on the epidemiology of HPV and cervical neoplasia and their associations with HIV. This study aimed to compare among HIV-1 seropositive and HIV-seronegative Ghanaian women: (1) t...

    Authors: Dorcas Obiri-Yeboah, Patrick K. Akakpo, Mohamed Mutocheluh, Emmanuel Adjei-Danso, Gloria Allornuvor, Daniel Amoako-Sakyi, Yaw Adu-Sarkodie and Philippe Mayaud
    Citation: BMC Cancer 2017 17:688
    Content type: Research article Published on:

  2. High birth weight (BW), 4000 g or larger, is an established risk factor for childhood leukemia. However, its association with central nervous system (CNS) tumor risk is yet unclear. The present study examined ...

    Authors: Long Thanh Tran, Hang Thi Minh Lai, Chihaya Koriyama, Futoshi Uwatoko and Suminori Akiba
    Citation: BMC Cancer 2017 17:687
    Content type: Research article Published on:

  3. The occurrence of cervical intraepithelial neoplasia (CIN) is associated with changes in health-related quality of life, including psychological factors, such as fear and shame, and changes in sexuality and se...

    Authors: Cristiane Menezes Sirna Fregnani, José Humberto Tavares Guerreiro Fregnani and Adhemar Longatto-Filho
    Citation: BMC Cancer 2017 17:686
    Content type: Research article Published on:

  4. Due to high survival rates and the relatively small benefit of adjuvant therapy, the application of personalized medicine (PM) through risk stratification is particularly beneficial in early breast cancer (BC)...

    Authors: Beate Jahn, Ursula Rochau, Christina Kurzthaler, Michael Hubalek, Rebecca Miksad, Gaby Sroczynski, Mike Paulden, Marvin Bundo, David Stenehjem, Diana Brixner, Murray Krahn and Uwe Siebert
    Citation: BMC Cancer 2017 17:685
    Content type: Research article Published on:

  5. Cytotoxic chemotherapeutics form the cornerstone of systemic treatment of many cancers. Patients are dosed at maximum tolerated dose (MTD), which is carefully determined in phase I studies. In contrast, in mur...

    Authors: Wayne J. Aston, Danika E. Hope, Anna K. Nowak, Bruce W. Robinson, Richard A. Lake and W. Joost Lesterhuis
    Citation: BMC Cancer 2017 17:684
    Content type: Research article Published on:

  6. The high burden of cervical cancer in Zambia prompted the Ministry of Health and partners to develop the cervical cancer prevention program in Zambia (CCPPZ) in 2006. Despite this intervention more women conti...

    Authors: Twaambo Euphemia Hamoonga, Rosemary Ndonyo Likwa, Patrick Musonda and Charles Michelo
    Citation: BMC Cancer 2017 17:681
    Content type: Research article Published on:

  7. Previous studies have found that polymorphisms of the DNA repair gene X-ray repair cross-complementing group 1(XRCC1) and environmental factors are both associated with an increased risk of stomach cancer, but no...

    Authors: Nuntiput Putthanachote, Supannee Promthet, Cameron Hurst, Krittika Suwanrungruang, Peechanika Chopjitt, Surapon Wiangnon, Sam Li-Sheng Chen, Amy Ming-Fang Yen and Tony Hsiu-Hsi Chen
    Citation: BMC Cancer 2017 17:680
    Content type: Research article Published on:

  9. Diffusion-weighted MR imaging (DWI) has increasingly contributed to the management of nasopharyngeal carcinoma (NPC) patients. The objective of this paper was to explore the prognostic significance of apparent...

    Authors: Dan-Fang Yan, Wen-Bao Zhang, Shan-Bao Ke, Feng Zhao, Sen-Xiang Yan, Qi-Dong Wang and Li-Song Teng
    Citation: BMC Cancer 2017 17:678
    Content type: Research article Published on:

  10. Both enzalutamide and abiraterone have demonstrated improved radiographic progression-free and overall survival for castration-resistant prostate cancer (CRPC) compared with placebo controls before docetaxel t...

    Authors: Kouji Izumi, Atsushi Mizokami, Mikio Namiki, Shogo Inoue, Nobumichi Tanaka, Yuko Yoshio, Kei Ishibashi, Manabu Kamiyama, Noriyasu Kawai, Hideki Enokida, Takashi Shima and Shizuko Takahara
    Citation: BMC Cancer 2017 17:677
    Content type: Study protocol Published on:

  12. Cutaneous basal cell carcinoma (BCC) is the commonest cancer worldwide. BCC is locally invasive and the surrounding stromal microenvironment is pivotal for tumourigenesis. Cancer associated fibroblasts (CAFs) ...

    Authors: Silje Haukali Omland, Erika Elgstrand Wettergren, Sarah Mollerup, Maria Asplund, Tobias Mourier, Anders Johannes Hansen and Robert Gniadecki
    Citation: BMC Cancer 2017 17:675
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2018 18:111

  13. Cancer patients experience pain that has physiological, sensory, affective, cognitive, behavioral, and sociocultural dimensions. Opioids are used in treatment of pain in patients with various types of cancer. ...

    Authors: Hiromichi Matsuoka, Junji Tsurutani, Yasutaka Chiba, Yoshihiko Fujita, Masato Terashima, Takeshi Yoshida, Kiyohiro Sakai, Yoichi Otake, Atsuko Koyama, Kazuto Nishio and Kazuhiko Nakagawa
    Citation: BMC Cancer 2017 17:674
    Content type: Study protocol Published on:

  14. Our previous study showed FOXM1 expression was significantly up-regulated in cervical cancer, and was associated with poor prognosis. To clarify miRNAs-FOXM1 modulation pathways, in this study, we investigated...

    Authors: Shanyang He, Bing Liao, Yalan Deng, Chang Su, Jiuling Tuo, Jun Liu, Shuzhong Yao and Lin Xu
    Citation: BMC Cancer 2017 17:673
    Content type: Research article Published on:

  15. Tumor invasion through a basement membrane is one of the earliest steps in metastasis, and growth factors, such as Epidermal Growth Factor (EGF) and Hepatocyte Growth Factor (HGF), stimulate this process in a ...

    Authors: Samantha S. Dykes, Joshua J. Steffan and James A. Cardelli
    Citation: BMC Cancer 2017 17:672
    Content type: Research article Published on:

  16. To assess the feasibility and potential impact on target delineation of respiratory-gated (4D) contrast-enhanced 18Fluorine fluorodeoxyglucose (FDG) positron emission tomography - computed tomography (PET-CT), in...

    Authors: Andrew Scarsbrook, Gillian Ward, Patrick Murray, Rebecca Goody, Karen Marshall, Garry McDermott, Robin Prestwich and Ganesh Radhakrishna
    Citation: BMC Cancer 2017 17:671
    Content type: Research article Published on:

  17. Slug is a transcription factor that activates the epithelial–mesenchymal transition (EMT) process in cancer progression. The aim of our study was to evaluate the clinical significance ...

    Authors: Han Hee Lee, Sung Hak Lee, Kyo Young Song, Sae Jung Na, Joo Hyun O, Jae Myung Park, Eun Sun Jung, Myung-Gyu Choi and Cho Hyun Park
    Citation: BMC Cancer 2017 17:670
    Content type: Research article Published on:

  18. After publication of the original article [1] the authors found the following author names were incorrect and needed to be amended:

    Authors: Norma Sánchez-Zauco, Javier Torres, Alejandro Gómez, Margarita Camorlinga-Ponce, Leopoldo Muñoz-Pérez, Roberto Herrera-Goepfert, Rafael Medrano-Guzmán, Silvia Giono-Cerezo and Carmen Maldonado-Bernal
    Citation: BMC Cancer 2017 17:669
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2017 17:384

  20. Authors: M. J. Murphy, J. M. Newby, P. Butow, L. Kirsten, K. Allison, S. Loughnan, M. A. Price, J. Shaw, H. Shepherd, J. Smith and G. Andrews
    Citation: BMC Cancer 2017 17:667
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2017 17:193

  22. Whole-lesion apparent diffusion coefficient (ADC) histogram analysis has been introduced and proved effective in assessment of multiple tumors. However, the application of whole-volume ADC histogram analysis i...

    Authors: Song Liu, Yujuan Zhang, Ling Chen, Wenxian Guan, Yue Guan, Yun Ge, Jian He and Zhengyang Zhou
    Citation: BMC Cancer 2017 17:665
    Content type: Research article Published on:

  23. Over half of men who receive treatment for prostate suffer from a range of sexual problems that affect negatively their sexual health, sexual intimacy with their partners and their quality of life. In clinical...

    Authors: D. Wittmann, A. Mehta, L. Northouse, R. Dunn, T. Braun, A. Duby, L. An, L. Arab, R. Bangs, S. Bober, J. Brandon, M. Coward, M. Dunn, M. Galbraith, M. Garcia, J. Giblin…
    Citation: BMC Cancer 2017 17:664
    Content type: Study protocol Published on:

  24. Lung cancer is one of the most commonly diagnosed cancers, and is a leading cause of cancer mortality world-wide. Due to lack of early specific symptoms, the majority of patients present with advanced, inopera...

    Authors: Lara Edbrooke, Sanchia Aranda, Catherine L. Granger, Christine F. McDonald, Mei Krishnasamy, Linda Mileshkin, Louis Irving, Sabine Braat, Ross A. Clark, Ian Gordon and Linda Denehy
    Citation: BMC Cancer 2017 17:663
    Content type: Study protocol Published on:

  25. The objective of this study was to compare the efficacy of biomarkers in assessing the risk of breast cancer recurrence in patients with node-negative or micrometastatic grade II breast cancer. Specifically, w...

    Authors: Elise Deluche, Laurence Venat-Bouvet, Sophie Leobon, Veronique Fermeaux, Joelle Mollard, Nadira Saidi, Isabelle Jammet, Yves Aubard and Nicole Tubiana-Mathieu
    Citation: BMC Cancer 2017 17:662
    Content type: Research article Published on:

  26. Secreted clusterin (sCLU), a 75–80 kDa disulfide-linked heterodimeric protein, plays crucial roles in various pathophysiological processes, including lipid transport, tissue remodeling, cell apoptosis and repr...

    Authors: Runsen Jin, Xingshi Chen, Dingpei Han, Xiaoying Luo and Hecheng Li
    Citation: BMC Cancer 2017 17:661
    Content type: Research article Published on:

  27. Metastasis is a major clinical problem whose biology is not yet fully understood. This lack of understanding is especially true for the events at the metastatic site, which include arrest, extravasation, and g...

    Authors: David C. Benjamin and Richard O. Hynes
    Citation: BMC Cancer 2017 17:660
    Content type: Technical advance Published on:

  28. Current evidence on risk of prostate cancer following a diagnosis of male breast cancer is limited and guidance for screening in this potentially higher-risk population remainsunclear. Our objective was to qua...

    Authors: Nikita Abhyankar, Kent F. Hoskins, Michael R. Abern and Gregory S. Calip
    Citation: BMC Cancer 2017 17:659
    Content type: Research article Published on:

  29. Cervical cancer is the second leading cause of death among female patients with cancer in the world. High risk human papillomavirus has causal roles in cervical cancer initiation and progression by deregulatin...

    Authors: Sunyoung Park, Kiyoon Eom, Jungho Kim, Hyeeun Bang, Hye-young Wang, Sungwoo Ahn, Geehyuk Kim, Hyoungsoon Jang, Sunghyun Kim, Dongsup Lee, Kwang Hwa Park and Hyeyoung Lee
    Citation: BMC Cancer 2017 17:658
    Content type: Research article Published on:

  30. There is evidence that some ovarian tumours evoke an immune response, which can be assessed by tumour infiltrating lymphocytes (TILs). To facilitate adoption of TILs as a clinical biomarker, a standardised met...

    Authors: Fiona R. James, Mercedes Jiminez-Linan, Jennifer Alsop, Marie Mack, Honglin Song, James D. Brenton, Paul D. P. Pharoah and H. Raza Ali
    Citation: BMC Cancer 2017 17:657
    Content type: Research article Published on:

  31. As more men survive a diagnosis of prostate cancer, alternative models of follow-up care that address men’s enduring unmet needs and are economical to deliver are needed. This paper describes the protocol for ...

    Authors: Jane Frankland, Hazel Brodie, Deborah Cooke, Claire Foster, Rebecca Foster, Heather Gage, Jake Jordan, Ines Mesa-Eguiagaray, Ruth Pickering and Alison Richardson
    Citation: BMC Cancer 2017 17:656
    Content type: Study protocol Published on:

  32. Non-small cell lung cancer (NSCLC) has led to the highest cancer-related mortality for decades. To enhance the efficiency of early diagnosis and therapy, more efforts are urgently needed to reveal the origins ...

    Authors: Rong-quan He, Xiao-jiao Li, Lu Liang, You Xie, Dian-zhong Luo, Jie Ma, Zhi-gang Peng, Xiao-hua Hu and Gang Chen
    Citation: BMC Cancer 2017 17:655
    Content type: Research article Published on:

  34. Clinical trials are necessary for the advancement of cancer treatment and care, however low rates of participation in such trials limit the generalisability of findings. The objective of this study was to exam...

    Authors: Mariko Carey, Allison W. Boyes, Rochelle Smits, Jamie Bryant, Amy Waller and Ian Olver
    Citation: BMC Cancer 2017 17:653
    Content type: Research article Published on:

  35. The increasing incidence and poor outcome associated with malignant pleural effusion (MPE) requires finding an effective treatment for this disease. Inhibitory B7-H4 is expressed in many different human cancer...

    Authors: Cheng Chen, Qiu-Xia Qu, Fang Xie, Wei-Dong Zhu, Ye-Han Zhu and Jian-An Huang
    Citation: BMC Cancer 2017 17:652
    Content type: Research article Published on:

  36. Five-year survival in patients with localized prostate cancer (PCa) is nearly 100%, but metastatic disease still remains incurable. Clinical management of metastatic patients has become increasingly complex as...

    Authors: Mariarosa Pascale, Che Ngwa Azinwi, Barbara Marongiu, Gianfranco Pesce, Flavio Stoffel and Enrico Roggero
    Citation: BMC Cancer 2017 17:651
    Content type: Research article Published on:

  37. Tartrate-resistant acid phosphatase (TRAP/ACP5), a metalloenzyme that is characteristic for its expression in activated osteoclasts and in macrophages, has recently gained considerable focus as a driver of metast...

    Authors: Anja Reithmeier, Elena Panizza, Michael Krumpel, Lukas M. Orre, Rui M. M. Branca, Janne Lehtiö, Barbro Ek-Rylander and Göran Andersson
    Citation: BMC Cancer 2017 17:650
    Content type: Research article Published on:

  38. In patients with BRAFV600 mutated unresectable stage IIIc or metastatic melanoma, molecular targeted therapy with combined BRAF/MEK-inhibitor vemurafenib plus cobimetinib has shown a significantly improved pro...

    Authors: Bernies van der Hiel, John B.A.G. Haanen, Marcel P.M. Stokkel, Daniel S. Peeper, Connie R. Jimenez, Jos H. Beijnen, Bart A. van de Wiel, Ronald Boellaard and Alfons J.M. van den Eertwegh
    Citation: BMC Cancer 2017 17:649
    Content type: Study protocol Published on:

  39. FOXP3 has been discovered to be expressed in tumor cells and participate in the regulation of tumor behavior. Herein, we investigated the clinical relevance and biological significance of FOXP3 expression in h...

    Authors: Jie-Yi Shi, Li-Jie Ma, Ji-Wei Zhang, Meng Duan, Zhen-Bin Ding, Liu-Xiao Yang, Ya Cao, Jian Zhou, Jia Fan, Xiaoming Zhang, Ying-Jun Zhao, Xiao-Ying Wang and Qiang Gao
    Citation: BMC Cancer 2017 17:648
    Content type: Research article Published on:

  40. The belief that early detection is the best protection against cancer underlies cancer screening. Emerging research now suggests harms associated with early detection may sometimes outweigh the benefits. Gover...

    Authors: S. Michelle Driedger, Gary Annable, Melissa Brouwers, Donna Turner and Ryan Maier
    Citation: BMC Cancer 2017 17:647
    Content type: Research article Published on:

  41. Human epidermal growth factor receptor 3 (HER3) is important in maintaining epidermal growth factor receptor-driven cancers and mediating resistance to targeted therapy. A phase I study of anti-HER3 monoclonal...

    Authors: Kerry Lynn Reynolds, Philippe L. Bedard, Se-Hoon Lee, Chia-Chi Lin, Josep Tabernero, Maria Alsina, Ezra Cohen, José Baselga, George Blumenschein Jr, Donna M. Graham, Ignacio Garrido-Laguna, Dejan Juric, Sunil Sharma, Ravi Salgia, Abdelkader Seroutou, Xianbin Tian…
    Citation: BMC Cancer 2017 17:646
    Content type: Research article Published on:

  42. Sorafenib and transarterial chemoembolization (TACE) are recommended therapies for advanced hepatocellular carcinoma (HCC), but their combined efficacy remains unclear.

    Authors: Fei-Xiang Wu, Jie Chen, Tao Bai, Shao-Liang Zhu, Tian-Bo Yang, Lu-Nan Qi, Ling Zou, Zi-Hui Li, Jia-Zhou Ye and Le-Qun Li
    Citation: BMC Cancer 2017 17:645
    Content type: Research article Published on:

  43. Integrator complex subunit 6 (INTS6) was found to play a tumour suppressing role in certain types of solid tumours. In this study, we wanted to determine the expression level of INTS6 in hepatocellular carcino...

    Authors: Ka Yin Lui, Hui Zhao, Chunhui Qiu, Chuo Li, Zhigang Zhang, Haoran Peng, Rongdang Fu, Hu-an Chen and Min-qiang Lu
    Citation: BMC Cancer 2017 17:644
    Content type: Research article Published on:

  44. Volumetric tumor staging has been shown as superior prognostic tool compared to the conventional TNM system in patients undergoing definitive intensity-modulated radiotherapy (IMRT) for head and neck cancer. R...

    Authors: Cédric Panje, Oliver Riesterer, Christoph Glanzmann and Gabriela Studer
    Citation: BMC Cancer 2017 17:643
    Content type: Research article Published on:

  45. A fusion gene is a hybrid gene consisting of parts from two previously independent genes. Chromosomal rearrangements leading to gene breakage are frequent in high-grade serous ovarian carcinomas and have been ...

    Authors: Marianne Lislerud Smebye, Antonio Agostini, Bjarne Johannessen, Jim Thorsen, Ben Davidson, Claes Göran Tropé, Sverre Heim, Rolf Inge Skotheim and Francesca Micci
    Citation: BMC Cancer 2017 17:642
    Content type: Research article Published on:

  46. Male breast cancer (MBC) represents a poorly characterised group of tumours, the management of which is largely based on practices established for female breast cancer. However, recent studies demonstrate biol...

    Authors: Siddhartha Deb, Kylie L. Gorringe, Jia-Min B. Pang, David J. Byrne, Elena A. Takano, kConFab Investigators, Alexander Dobrovic and Stephen B. Fox
    Citation: BMC Cancer 2017 17:641
    Content type: Research article Published on:

  47. Breast cancer is the most common cancer in females and is ranked second in cancer-related deaths all over the world in women. Despite improvement in diagnosis, the survival rate of this disease has still not i...

    Authors: Azhar R. Hussain, Abdul Khalid Siraj, Maqbool Ahmed, Rong Bu, Poyil Pratheeshkumar, Alanood M. Alrashed, Zeeshan Qadri, Dahish Ajarim, Fouad Al-Dayel, Shaham Beg and Khawla S. Al-Kuraya
    Citation: BMC Cancer 2017 17:640
    Content type: Research article Published on:

  48. Uterine leiomyosarcoma (ULMS) is an aggressive form of soft tissue tumors. The molecular heterogeneity and pathogenesis of ULMS are not well understood.

    Authors: Yang An, Shuzhen Wang, Songlin Li, Lulu Zhang, Dayong Wang, Haojie Wang, Shibai Zhu, Wan Zhu, Yongqiang Li, Wenwu Chen, Shaoping Ji and Xiangqian Guo
    Citation: BMC Cancer 2017 17:639
    Content type: Research article Published on:

  49. Phosphatase and Tensin homolog (PTEN) is a tumor suppressor gene. Loss of its function is the most frequent genetic alteration in endometrioid endometrial cancers (70–80%) and high grade tumors (90%). We asses...

    Authors: Charles-André Philip, Ido Laskov, Marie-Claude Beauchamp, Maud Marques, Oreekha Amin, Joanna Bitharas, Roy Kessous, Liron Kogan, Tahira Baloch, Walter H. Gotlieb and Amber Yasmeen
    Citation: BMC Cancer 2017 17:638
    Content type: Research article Published on:

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