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  1. Liver resection had been regarded as a standard treatment for primary hepatocellular carcinoma (HCC). However, early mortality and recurrence after surgery were still of major concern. RAM (Risk Assessment for...

    Authors: Heng-Yuan Hsu, Ming-Chin Yu, Chao-Wei Lee, Hsin-I Tsai, Chang-Mu Sung, Chun-Wei Chen, Shu-Wei Huang, Cheng-Yu Lin, Wen-Juei Jeng, Wei-Chen Lee and Miin-Fu Chen
    Citation: BMC Cancer 2017 17:742
    Content type: Research article Published on:

  2. Understanding the underlying molecular mechanisms involved in the formation of cutaneous malignant melanoma is critical for improved diagnosis and treatment. Keratinocytic nuclear receptor Retinoid X Receptor ...

    Authors: Sharmeen Chagani, Rong Wang, Evan L. Carpenter, Christiane V. Löhr, Gitali Ganguli-Indra and Arup K. Indra
    Citation: BMC Cancer 2017 17:736
    Content type: Research article Published on:

  3. Pregnancy is an unquantifiable risk to accelerate tumor growth of papillary thyroid carcinoma (PTC), and whether pregnancy induces an unfavorable prognosis of radioiodine refractory papillary thyroid carcinoma...

    Authors: Yuchen Jin, Min Liu, Lingxiao Cheng and Libo Chen
    Citation: BMC Cancer 2017 17:735
    Content type: Case report Published on:

  4. Data is needed about barriers to self-collection of Human Papillomavirus (HPV) samples and cytology among low-income, disadvantaged women living in rural areas of lower-income countries as these women are at i...

    Authors: Betania Allen-Leigh, Patricia Uribe-Zúñiga, Leith León-Maldonado, Brandon J. Brown, Attila Lörincz, Jorge Salmeron and Eduardo Lazcano-Ponce
    Citation: BMC Cancer 2017 17:734
    Content type: Research article Published on:

  5. There are three main therapeutic strategies, namely expectant management (dilation and curettage only), prophylactic chemotherapy and prophylactic total hysterectomy for treating older women with complete hyda...

    Authors: Peng Zhao, Qinqing Chen and Weiguo Lu
    Citation: BMC Cancer 2017 17:733
    Content type: Research article Published on:

  6. Colorectal cancer (CRC) is a major global public health problem and the second leading cause of cancer-related death. Mitochondrial dysfunction has long been suspected to be involved in this type of tumorigene...

    Authors: Jéssica Alonso-Molero, Carmen González-Donquiles, Tania Fernández-Villa, Fernanda de Souza-Teixeira, Laura Vilorio-Marqués, Antonio J. Molina and Vicente Martín
    Citation: BMC Cancer 2017 17:731
    Content type: Research article Published on:

  7. Circulating cell-free miRNAs have emerged as promising minimally-invasive biomarkers for early detection, prognosis and monitoring of cancer. They can exist in the bloodstream incorporated into extracellular v...

    Authors: Edgars Endzeliņš, Andreas Berger, Vita Melne, Cristina Bajo-Santos, Kristīne Soboļevska, Artūrs Ābols, Marta Rodriguez, Daiga Šantare, Anastasija Rudņickiha, Vilnis Lietuvietis, Alicia Llorente and Aija Linē
    Citation: BMC Cancer 2017 17:730
    Content type: Research article Published on:

  8. Patients suffering from advanced stage hepatocellular carcinoma (HCC) often exhibit a poor prognosis or dismal clinical outcomes due to ineffective chemotherapy or a multi-drug resistance (MDR) process. Thus, ...

    Authors: Jun Hou, Zhixian Hong, Fan Feng, Yantao Chai, Yunkai Zhang, Qiyu Jiang, Yan Hu, Shunquan Wu, Yingsong Wu, Xunian Gao, Qiong Chen, Yong Wan, Jingfeng Bi and Zheng Zhang
    Citation: BMC Cancer 2017 17:729
    Content type: Research article Published on:

  9. MicroRNAs may act as oncogenes or tumour suppressor genes, which make these small molecules potential diagnostic/prognostic factors and targets for anticancer therapies. Several common oncogenic microRNAs have...

    Authors: Malgorzata Bulkowska, Agata Rybicka, Kerem Mert Senses, Katarzyna Ulewicz, Katarzyna Witt, Joanna Szymanska, Bartlomiej Taciak, Robert Klopfleisch, Eva Hellmén, Izabella Dolka, Ali O. Gure, Joanna Mucha, Mariusz Mikow, Slawomir Gizinski and Magdalena Krol
    Citation: BMC Cancer 2017 17:728
    Content type: Research article Published on:

  10. Triple-negative breast cancer (TNBC) is characterized by a lack of estrogen and progesterone receptor expression (ESR and PGR, respectively) and an absence of human epithelial growth factor receptor (ERBB2) ampli...

    Authors: Melissa Quintero, Douglas Adamoski, Larissa Menezes dos Reis, Carolline Fernanda Rodrigues Ascenção, Krishina Ratna Sousa de Oliveira, Kaliandra de Almeida Gonçalves, Marília Meira Dias, Marcelo Falsarella Carazzolle and Sandra Martha Gomes Dias
    Citation: BMC Cancer 2017 17:727
    Content type: Research article Published on:

  12. Circulating tumor cells (CTCs) have been accepted as a prognostic marker in patients with metastatic colorectal cancer (mCRC, UICC stage IV). However, the prognostic value of CTCs in patients with non-metastat...

    Authors: Chaogang Yang, Kun Zou, Liang Zheng and Bin Xiong
    Citation: BMC Cancer 2017 17:725
    Content type: Research article Published on:

  14. The aim of this study was to identify miRNAs specifically dysregulated in BRAF-mutated colorectal cancer, which could lead to a better understanding of the molecular mechanisms underlying oncogenesis of this mali...

    Authors: Hidekazu Takahashi, Masanobu Takahashi, Shinobu Ohnuma, Michiaki Unno, Yuki Yoshino, Kota Ouchi, Shin Takahashi, Yasuhide Yamada, Hideki Shimodaira and Chikashi Ishioka
    Citation: BMC Cancer 2017 17:723
    Content type: Research article Published on:

  15. Trastuzumab-related cardiotoxicity has been reported in patients receiving trastuzumab concurrently with other agents, especially with anthracyclines. Cardiac function damage is generally rare, precox and mild...

    Authors: Santino Minichillo, Ilaria Gallelli, Elena Barbieri, Marta Cubelli, Daniela Rubino, Sara Quercia, Massimo Dall’Olio, Claudio Rapezzi and Claudio Zamagni
    Citation: BMC Cancer 2017 17:722
    Content type: Case report Published on:

  16. To evaluate the safety and efficacy of carbon ion radiotherapy (C-ion RT) for 80 years or older patients with hepatocellular carcinoma (HCC).

    Authors: Shintaro Shiba, Takanori Abe, Kei Shibuya, Hiroyuki Katoh, Yoshinori Koyama, Hirohumi Shimada, Satoru Kakizaki, Ken Shirabe, Hiroyuki Kuwano, Tatsuya Ohno and Takashi Nakano
    Citation: BMC Cancer 2017 17:721
    Content type: Research article Published on:

  17. Hereditary diffuse gastric carcinoma (HDGC) accounts for 1–3% of all gastric carcinomas. Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the gastrointestinal (GI) tract but th...

    Authors: Huijie Fan, Pei Lu, Li Xu, Yanru Qin and Jing Li
    Citation: BMC Cancer 2017 17:720
    Content type: Case report Published on:

  18. Epithelial-mesenchymal transition (EMT) is an early event in tumour invasion and metastasis, and widespread and distant metastasis at early stages is the typical biological behaviour in small cell lung cancer ...

    Authors: Tingting Wang, Xufang Chen, Weiwei Qiao, Lijun Kong, Daqing Sun and Zunling Li
    Citation: BMC Cancer 2017 17:719
    Content type: Research article Published on:

  19. Multiple Myeloma is a cancer of plasma cells associated with significantly reduced survival. Long term survivorship from myeloma is very rare and despite advances in its treatment the disease is generally cons...

    Authors: Vallari Shah, Kevin D. Boyd, Richard S. Houlston and Martin F. Kaiser
    Citation: BMC Cancer 2017 17:718
    Content type: Case report Published on:

  20. Gastrointestinal stromal tumours (GIST) are rarely encountered mesenchymal tumours of the gastrointestinal tract (1.5 people per 100,000/year) that are even more rarely seen in paediatric patients (1–2% of all...

    Authors: Piotr Rutkowski, Heather Magnan, Alexander J. Chou and Charlotte Benson
    Citation: BMC Cancer 2017 17:717
    Content type: Research article Published on:

  21. Cancer stem cells (CSCs) are considered to be the major factor in tumor initiation, progression, metastasis, recurrence and chemoresistance. Maintaining the stemness and promoting differentiation of these cell...

    Authors: Xiaofeng Yu, Lin Mi, Jie Dong and Jian Zou
    Citation: BMC Cancer 2017 17:716
    Content type: Research article Published on:

  22. Most efforts to advance cancer survivorship care have occurred in Western countries. There has been limited research towards gaining a comprehensive understanding of survivorship care provision in the Asia-Pac...

    Authors: Raymond Javan Chan, Patsy Yates, Qiuping Li, Hiroko Komatsu, Violeta Lopez, Myat Thandar, Selva Titus Chacko, Winnie Kwok Wei So, Kanaungnit Pongthavornkamol, Myungsun Yi, Pongpak Pittayapan, Jesson Butcon, David Wyld and Alex Molassiotis
    Citation: BMC Cancer 2017 17:715
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2018 18:240

  23. Many studies have combined sorafenib with transcatheter arterial chemoembolization (TACE) to treat patients with advanced hepatocellular carcinoma (HCC), but the results are disputable. Thus, we conducted this...

    Authors: Rong Cai, Rongfeng Song, Pengfei Pang, Yan Yan, Yifeng Liao, Cuiling Zhou, Shuncong Wang, Xiuling Zhou, Huaping Wang, Hongyu Zhang, Huanhuan Sun and Haiqing Ma
    Citation: BMC Cancer 2017 17:714
    Content type: Research article Published on:

  24. On conventional diagnostic imaging, the features of radiation necrosis (RN) are similar to those of local recurrence (LR) of brain metastases (BM). 11C–methionine positron emission tomography (MET-PET) is reporte...

    Authors: Shoji Yomo and Kazuhiro Oguchi
    Citation: BMC Cancer 2017 17:713
    Content type: Research article Published on:

  25. Adequate working space and a clear view for the dissected lesion are crucial for endoscopic submucosal dissection (ESD). Pharyngeal ESD requires that an otorhinolaryngologist creates working space by lifting t...

    Authors: Lianjun Di, Kuang-I Fu, Rui Xie, Xinglong Wu, Youfeng Li, Huichao Wu and Biguang Tuo
    Citation: BMC Cancer 2017 17:712
    Content type: Case report Published on:

  26. Widely established targeted therapies directed at triple negative breast cancer (TNBC) are missing. Classical chemotherapy remains the systemic treatment option. Cisplatin has been tested in TNBC but bears the...

    Authors: Katharina Gohr, Alexandra Hamacher, Laura H. Engelke and Matthias U. Kassack
    Citation: BMC Cancer 2017 17:711
    Content type: Research article Published on:

  27. To investigate whether the incorporation of 18FDG-PET into the automatic treatment planning process may be able to decrease the dose to active bone marrow (BM) for locally advanced anal cancer patients undergoing...

    Authors: Pierfrancesco Franco, Christian Fiandra, Francesca Arcadipane, Elisabetta Trino, Francesca Romana Giglioli, Riccardo Ragona and Umberto Ricardi
    Citation: BMC Cancer 2017 17:710
    Content type: Technical advance Published on:

  28. Breast cancer is the most common invasive cancer among women. Currently, there are only a few models used for therapy selection, and they are often poor predictors of therapeutic response or take months to set...

    Authors: Henriette L. Lanz, Anthony Saleh, Bart Kramer, Junmei Cairns, Chee Ping Ng, Jia Yu, Sebastiaan J. Trietsch, Thomas Hankemeier, Jos Joore, Paul Vulto, Richard Weinshilboum and Liewei Wang
    Citation: BMC Cancer 2017 17:709
    Content type: Technical advance Published on:

  29. The differentiation of pancreatic ductal adenocarcinoma (PDAC) could be associated with prognosis and may influence the choices of clinical management. No applicable methods could reliably predict the tumor di...

    Authors: Shi Wen, Bohan Zhan, Jianghua Feng, Weize Hu, Xianchao Lin, Jianxi Bai and Heguang Huang
    Citation: BMC Cancer 2017 17:708
    Content type: Research article Published on:

  30. microRNAs are small non-protein-coding RNA molecules that regulate gene expression, and have a potential epigenetic role in disease progression and survival of colorectal cancer. In terms of tumor-normal expre...

    Authors: John R. Stevens, Jennifer S. Herrick, Roger K. Wolff and Martha L. Slattery
    Citation: BMC Cancer 2017 17:707
    Content type: Research article Published on:

  31. Oral cancer is a potentially fatal disease, especially when diagnosed in advanced stages. In Brazil, the primary health care (PHC) system is responsible for promoting oral health in order to prevent oral disea...

    Authors: Thiago Augusto Hernandes Rocha, Erika Bárbara Abreu Fonseca Thomaz, Núbia Cristina da Silva, Rejane Christine de Sousa Queiroz, Marta Rovery de Souza, Allan Claudius Queiroz Barbosa, Elaine Thumé, João Victor Muniz Rocha, Viviane Alvares, Dante Grapiuna de Almeida, João Ricardo Nickenig Vissoci, Catherine Ann Staton and Luiz Augusto Facchini
    Citation: BMC Cancer 2017 17:706
    Content type: Research article Published on:

  32. PTTG1-interacting protein (PTTG1IP) is an oncogenic protein, which participates in metaphase-anaphase transition of the cell cycle through activation of securin (PTTG1). PTTG1IP promotes the shift of securin f...

    Authors: Heli Repo, Natalia Gurvits, Eliisa Löyttyniemi, Marjukka Nykänen, Minnamaija Lintunen, Henna Karra, Samu Kurki, Teijo Kuopio, Kati Talvinen, Mirva Söderström and Pauliina Kronqvist
    Citation: BMC Cancer 2017 17:705
    Content type: Research article Published on:

  33. The Victorian Prostate Cancer Registry (Australia) revealed poorer rates of survival for men diagnosed with prostate cancer in one Victorian regional area than for men in metropolitan Melbourne. We sought to e...

    Authors: Maggie Kirkman, Kate Young, Susan Evans, Jeremy Millar, Jane Fisher, Danielle Mazza and Rasa Ruseckaite
    Citation: BMC Cancer 2017 17:704
    Content type: Research article Published on:

  34. Aim of this study was to compare cancer incidence in populations with and without diabetes by cancer site. Furthermore, we aimed at comparing excess risk of cancer according to diabetes type, diabetes duration...

    Authors: Paola Ballotari, Massimo Vicentini, Valeria Manicardi, Marco Gallo, Sofia Chiatamone Ranieri, Marina Greci and Paolo Giorgi Rossi
    Citation: BMC Cancer 2017 17:703
    Content type: Research article Published on:

  36. Lifestyle recommendations for cancer survivors are warranted to improve survival. In this study, we aimed to examine the association of total physical activity, different types of physical activity, hours of s...

    Authors: Ilka Ratjen, Clemens Schafmayer, Romina di Giuseppe, Sabina Waniek, Sandra Plachta-Danielzik, Manja Koch, Greta Burmeister, Ute Nöthlings, Jochen Hampe, Sabrina Schlesinger and Wolfgang Lieb
    Citation: BMC Cancer 2017 17:701
    Content type: Research article Published on:

  37. Similar to most solid tumors, the incidence of hematologic malignancies has been rising. Although the median age at diagnosis is about 70 years, little is known about psychosocial aspects and comorbid conditio...

    Authors: Norbert Köhler, Anja Mehnert and Heide Götze
    Citation: BMC Cancer 2017 17:700
    Content type: Study protocol Published on:

  38. Cancer survivors are at risk of developing a second primary cancer (SPC) later in life because of persisting effects of genetic and behavioural risk factors, the long-term sequelae of chemotherapy, radiotherap...

    Authors: Oliver Preyer, Nicole Concin, Andreas Obermair, Hans Concin, Hanno Ulmer and Willi Oberaigner
    Citation: BMC Cancer 2017 17:699
    Content type: Research article Published on:

  39. Quantifying the response of cell lines to drugs or other perturbagens is the cornerstone of pre-clinical drug development and pharmacogenomics as well as a means to study factors that contribute to sensitivity...

    Authors: Nicholas A. Clark, Marc Hafner, Michal Kouril, Elizabeth H. Williams, Jeremy L. Muhlich, Marcin Pilarczyk, Mario Niepel, Peter K. Sorger and Mario Medvedovic
    Citation: BMC Cancer 2017 17:698
    Content type: Software Published on:

  40. The presence of circulating cell-free DNA from tumours in blood (ctDNA) is of major importance to those interested in early cancer detection, as well as to those wishing to monitor tumour progression or diagno...

    Authors: Ian A. Cree, Lesley Uttley, Helen Buckley Woods, Hugh Kikuchi, Anne Reiman, Susan Harnan, Becky L. Whiteman, Sian Taylor Philips, Michael Messenger, Angela Cox, Dawn Teare, Orla Sheils and Jacqui Shaw
    Citation: BMC Cancer 2017 17:697
    Content type: Research article Published on:

  41. Our research aimed to investigate whether lymphadenectomy was required in patients with intermediate-risk endometrioid endometrial cancer (EEC).

    Authors: Menghan Zhu, Nan Jia, Feifei Huang, Xiaoxia Liu, Yuqing Zhao, Xiang Tao, Wei Jiang, Qin Li and Weiwei Feng
    Citation: BMC Cancer 2017 17:696
    Content type: Research article Published on:

  43. The emergence of chemoresistant cancers and toxicity related to existing chemotherapeutic agents, demand the search for new pharmacophore with enhanced anti-cancer activity and least toxicity. For this purpose...

    Authors: Umar Farooq, Sadia Naz, Binte Zehra, Ajmal Khan, Syed Abid Ali, Ayaz Ahmed, Rizwana Sarwar, Syed Majid Bukhari, Abdur Rauf, Izhar Ahmad and Yahia Nasser Mabkhot
    Citation: BMC Cancer 2017 17:694
    Content type: Research article Published on:

  45. Women may have incomplete understanding of a breast cancer diagnosis, leading to inaccurate reporting in epidemiological studies. However, it is not feasible to obtain consent for medical records from all wome...

    Authors: Aimee A. D’Aloisio, Hazel B. Nichols, M. Elizabeth Hodgson, Sandra L. Deming-Halverson and Dale P. Sandler
    Citation: BMC Cancer 2017 17:692
    Content type: Research article Published on:

  46. Metastatic colorectal cancer imposes a substantial burden on patients and society. Over the last years, progresses in the treatment have been made especially due to the introduction of monoclonal antibodies, s...

    Authors: Andrea Queiróz Ungari, Leonardo Régis Leira Pereira, Altacílio Aparecido Nunes and Fernanda Maris Peria
    Citation: BMC Cancer 2017 17:691
    Content type: Research article Published on:

  47. Programmed cell death-ligand 1 (PD-L1) may be a useful molecule for targeted immunotherapy. Therefore, this meta-analysis aimed to investigate PD-L1 expression in breast cancer and its associations with clinic...

    Authors: Hye Min Kim, Jinae Lee and Ja Seung Koo
    Citation: BMC Cancer 2017 17:690
    Content type: Research article Published on:

  48. No studies have measured preference-based utility weights for specific toxicities and outcomes associated with approved and investigational adjuvant treatments for patients with resected high-risk melanoma.

    Authors: Mark R. Middleton, Michael B. Atkins, Kaitlan Amos, Peter Feng Wang, Srividya Kotapati, Javier Sabater and Kathleen Beusterien
    Citation: BMC Cancer 2017 17:689
    Content type: Research article Published on:

  49. We aimed to evaluate the efficacy and safety of nab-paclitaxel in patients with refractory advanced non-small cell lung cancer who failed previous chemotherapy.

    Authors: Hisashi Tanaka, Kageaki Taima, Takeshi Morimoto, Yoshihito Tanaka, Masamichi Itoga, Kunihiko Nakamura, Akihito Hayashi, Mika Kumagai, Hideo Yasugahira, Megumi Mikuniya, Koichi Okudera, Shingo Takanashi and Sadatomo Tasaka
    Citation: BMC Cancer 2017 17:683
    Content type: Research article Published on:

  50. It is estimated that a total of 120,000 new cancer cases in men and in women in more developed countries could be avoided if exposure to HPV was prevented. We used the nationwide pool of German population-base...

    Authors: Nina Buttmann-Schweiger, Yvonne Deleré, Stefanie J. Klug and Klaus Kraywinkel
    Citation: BMC Cancer 2017 17:682
    Content type: Research article Published on:

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