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  1. We evaluated treatment decisions and outcomes in a cohort of predominately Caucasian patients with EGFR mutation-positive (EGFR Mut+) non-small-cell lung cancer (NSCLC).

    Authors: Wolfgang Schuette, Peter Schirmacher, Wilfried E. E. Eberhardt, Manfred Dietel, Ute Zirrgiebel, Lars Muehlenhoff and Michael Thomas
    Citation: BMC Cancer 2018 18:135
    Content type: Research article Published on:

  2. Extra-uterine mullerian adenosarcomas have varying biological behaviours depending on the presence of endometriosis or sarcomatous overgrowth. These behaviours manifest according to the tumours’ histological c...

    Authors: Vincenzo Dario Mandato, Federica Torricelli, Valentina Mastrofilippo, Riccardo Valli, Lorenzo Aguzzoli and Giovanni Battista La Sala
    Citation: BMC Cancer 2018 18:134
    Content type: Case report Published on:

  3. The heterogeneous behavior of patients with melanoma makes prognostication challenging. To address this, a gene expression profile (GEP) test to predict metastatic risk was previously developed. This study eva...

    Authors: Jonathan S. Zager, Brian R. Gastman, Sancy Leachman, Rene C. Gonzalez, Martin D. Fleming, Laura K. Ferris, Jonhan Ho, Alexander R. Miller, Robert W. Cook, Kyle R. Covington, Kristen Meldi-Plasseraud, Brooke Middlebrook, Lewis H. Kaminester, Anthony Greisinger, Sarah I. Estrada, David M. Pariser…
    Citation: BMC Cancer 2018 18:130
    Content type: Research article Published on:

  4. Tumour-infiltrating lymphocytes (TILs) have been demonstrated to significantly influence prognosis and response to therapy of invasive breast cancer (IBC). Thus, it has been suggested that TIL density or/and i...

    Authors: Marie Beguinot, Marie-Melanie Dauplat, Fabrice Kwiatkowski, Guillaume Lebouedec, Lucie Tixier, Christophe Pomel, Frederique Penault-Llorca and Nina Radosevic-Robin
    Citation: BMC Cancer 2018 18:129
    Content type: Research article Published on:

  5. Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a candidate diagnostic and prognostic biomarker for pancreatic ductal adenocarcinoma (PDAC). Here, we determined the possible association of systemic TIMP-1...

    Authors: Olga Prokopchuk, Barbara Grünwald, Ulrich Nitsche, Carsten Jäger, Oleksii L. Prokopchuk, Elaine C. Schubert, Helmut Friess, Marc E. Martignoni and Achim Krüger
    Citation: BMC Cancer 2018 18:128
    Content type: Research article Published on:

  6. Nc886 is a 102 bp non-coding RNA transcript initially classified as a microRNA precursor (Pre-miR-886), later as a divergent homologue of the vault RNAs (vtRNA 2–1) and more recently as a novel type of RNA (nc...

    Authors: Rafael Sebastián Fort, Cecilia Mathó, Murilo Vieira Geraldo, María Carolina Ottati, Alex Shimura Yamashita, Kelly Cristina Saito, Katia Ramos Moreira Leite, Manuel Méndez, Noemí Maedo, Laura Méndez, Beatriz Garat, Edna Teruko Kimura, José Roberto Sotelo-Silveira and María Ana Duhagon
    Citation: BMC Cancer 2018 18:127
    Content type: Research article Published on:

  7. Quality indicators for the Brazilian cervical cancer screening programme can provide a perspective on its effectiveness in Brazilian macro-regions and states. The aim of this study was to perform a trend analy...

    Authors: Ricardo Filipe Alves Costa, Adhemar Longatto-Filho, Fabiana de Lima Vazquez, Céline Pinheiro, Luiz Carlos Zeferino and José Humberto Tavares Guerreiro Fregnani
    Citation: BMC Cancer 2018 18:126
    Content type: Research article Published on:

  8. Patients with primary brain tumors are reported to have an elevated level of distress prevalence, due to the functional sequelae and the unfavorable prognosis, but the estimated prevalence of this disorder var...

    Authors: Fangkun Liu, Jing Huang, Liyang Zhang, Fan Fan, Jindong Chen, Kun Xia and Zhixiong Liu
    Citation: BMC Cancer 2018 18:124
    Content type: Research article Published on:

  9. The tumour microenvironment consists of malignant cells, stroma and immune cells. In women with large and locally advanced breast cancers (LLABCs) undergoing neoadjuvant chemotherapy (NAC), tumour-infiltrating...

    Authors: Viriya Kaewkangsadan, Chandan Verma, Jennifer M. Eremin, Gerard Cowley, Mohammad Ilyas and Oleg Eremin
    Citation: BMC Cancer 2018 18:123
    Content type: Research article Published on:

  10. Hodgkin’s lymphoma (HL) and anaplastic large-cell lymphoma (ALCL) are the two most common tumors expressing CD30. Internationally, a clinical study that is being conducted involving adults with recurrent or re...

    Authors: Masahiro Sekimizu, Akihiro Iguchi, Tetsuya Mori, Yuhki Koga, Akiko Kada, Akiko M. Saito and Keizo Horibe
    Citation: BMC Cancer 2018 18:122
    Content type: Study protocol Published on:

  11. Oestrogen receptors (ER) have a well-established role to the initiation, progression and regulation of responses to treatment of breast, prostate, and lung cancers. Previous data indicates altered ER expressio...

    Authors: Waleed Al-Khyatt, Cristina Tufarelli, Raheela Khan and Syed Yousef Iftikhar
    Citation: BMC Cancer 2018 18:121
    Content type: Research article Published on:

  12. Ramucirumab has recently proved to be effective for advanced or recurrent gastric cancer (AGC). Ascites and peritoneal metastasis are among the most common complications of AGC. However, there are few data on ...

    Authors: Hiroshi Matsumoto, Akihito Kawazoe, Kaoru Shimada, Shota Fukuoka, Yasutoshi Kuboki, Hideaki Bando, Takashi Kojima, Atsushi Ohtsu, Takayuki Yoshino, Toshihiko Doi and Kohei Shitara
    Citation: BMC Cancer 2018 18:120
    Content type: Research article Published on:

  13. Metastatic breast cancer (BCa) is most often diagnosed months after completion of treatment of the primary tumor when a patient reports physical symptoms. Besides a physical examination, no other alternative r...

    Authors: Rick L. Evans, James V. Pottala, Satoshi Nagata and Kristi A. Egland
    Citation: BMC Cancer 2018 18:119
    Content type: Research article Published on:

  14. Neoadjuvant chemotherapy (NAC) is extensively used in the treatment of patients with gastric cancer (GC), particularly in high risk, advanced gastric cancer. Previous trials testing the efficacy of NAC have re...

    Authors: Zhi-Feng Miao, Xing-Yu Liu, Zhen-Ning Wang, Ting-Ting Zhao, Ying-Ying Xu, Yong-Xi Song, Jin-Yu Huang, Hao Xu and Hui-Mian Xu
    Citation: BMC Cancer 2018 18:118
    Content type: Research article Published on:

  15. Radiofrequency ablation (RFA) can not only effectively kill hepatocellular carcinoma (HCC) tumour cells but also release tumour antigens that can provoke an immune response. However, there is no consensus rega...

    Authors: Shunli Shen, Hong Peng, Ye Wang, Ming Xu, Manxia Lin, Xiaoyan Xie, Baogang Peng and Ming Kuang
    Citation: BMC Cancer 2018 18:117
    Content type: Research article Published on:

  16. Pancreatic cancer is associated with an extremely poor prognosis, so new biomarkers that can detect the initial stages are urgently needed. The significance of serum microRNA (miR) levels in pancreatic neoplas...

    Authors: Takuma Goto, Mikihiro Fujiya, Hiroaki Konishi, Junpei Sasajima, Shugo Fujibayashi, Akihiro Hayashi, Tatsuya Utsumi, Hiroki Sato, Takuya Iwama, Masami Ijiri, Aki Sakatani, Kazuyuki Tanaka, Yoshiki Nomura, Nobuhiro Ueno, Shin Kashima, Kentaro Moriichi…
    Citation: BMC Cancer 2018 18:116
    Content type: Research article Published on:

  17. Lung cancer is the leading cause of cancer-related mortality in Utah despite having the nation’s lowest smoking rate. Radon exposure and differences in lung cancer incidence between nonmetropolitan and metropo...

    Authors: Judy Y. Ou, Brynn Fowler, Qian Ding, Anne C. Kirchhoff, Lisa Pappas, Kenneth Boucher, Wallace Akerley, Yelena Wu, Kimberly Kaphingst, Garrett Harding and Deanna Kepka
    Citation: BMC Cancer 2018 18:115
    Content type: Research article Published on:

  18. To evaluate the prognostic significance of pretreatment quality of life for patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy.

    Authors: Shan-Shan Guo, Wen Hu, Qiu-Yan Chen, Jian-Mei Li, Shi-Heng Zhu, Yan He, Jia-Wen Li, Le Xia, Lu Ji, Cui-Ying Lin, Li-Ting Liu, Lin-Quan Tang, Ling Guo, Hao-Yuan Mo, Chong Zhao, Xiang Guo…
    Citation: BMC Cancer 2018 18:114
    Content type: Research article Published on:

  19. Cisplatin is the most commonly used chemotherapeutic agent in the treatment of patients with metastatic and/or recurrent urothelial cancer. However, the effectiveness of these treatments is severely limited du...

    Authors: Masayuki Hagiwara, Eiji Kikuchi, Nobuyuki Tanaka, Takeo Kosaka, Shuji Mikami, Hideyuki Saya and Mototsugu Oya
    Citation: BMC Cancer 2018 18:113
    Content type: Research article Published on:

  20. The new nine-valent vaccine against human papillomavirus (HPV) includes the four HPV genotypes (6, 11, 16, and 18) that are targeted by the older quadrivalent HPV vaccine, plus five additional oncogenic types ...

    Authors: María Paz-Zulueta, Ledicia Álvarez-Paredes, Juan Carlos Rodríguez Díaz, Paula Parás-Bravo, Ma. Encarnación Andrada Becerra, José María Rodríguez Ingelmo, María Montserrat Ruiz García, Joaquín Portilla and Miguel Santibañez
    Citation: BMC Cancer 2018 18:112
    Content type: Research article Published on:

  21. After publication of the original article [1] it was identified that order of the author list had been presented incorrectly. The author Robert Gniadecki’s surname was also incorrect in the original article.

    Authors: Silje Haukali Omland, Erika Elgstrand Wettergren, Sarah Mollerup, Maria Asplund, Tobias Mourier, Anders Johannes Hansen and Robert Gniadecki
    Citation: BMC Cancer 2018 18:111
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2017 17:675

  22. After publication of the original article [1] the authors found that Table 2 had been formatted incorrectly, meaning that some rows in the Table did not display the correct information.

    Authors: Marie Lange, Heidi Laviec, Hélène Castel, Natacha Heutte, Alexandra Leconte, Isabelle Léger, Bénédicte Giffard, Aurélie Capel, Martine Dubois, Bénédicte Clarisse, Elodie Coquan, Frédéric Di Fiore, Sophie Gouérant, Philippe Bartélémy, Laure Pierard, Karim Fizazi…
    Citation: BMC Cancer 2018 18:110
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2017 17:549

  23. Although adjuvant chemotherapy with S-1 after curative gastrectomy has been performed as a standard treatment for Stage II and III gastric cancer (GC) in Japan, patients with Stage III GC still have a high inc...

    Authors: Keiji Nishibeppu, Shuhei Komatsu, Daisuke Ichikawa, Taisuke Imamura, Toshiyuki Kosuga, Kazuma Okamoto, Hirotaka Konishi, Atsushi Shiozaki, Hitoshi Fujiwara and Eigo Otsuji
    Citation: BMC Cancer 2018 18:108
    Content type: Research article Published on:

  24. MicroRNAs (miRNAs or miRs) are small molecules known to be involved in post-transcriptional gene expression. Many of them have been shown to influence risk for various diseases. Recent studies suggest that low...

    Authors: Aleksandra Butrym, Piotr Łacina, Kazimierz Kuliczkowski, Katarzyna Bogunia-Kubik and Grzegorz Mazur
    Citation: BMC Cancer 2018 18:107
    Content type: Research article Published on:

  25. Although the benefit of first-line epidermal growth factor receptor (EGFR) tyrosine-kinase inhibitors (TKIs) over chemotherapy has been demonstrated in several clinical trials, data from clinical practice is l...

    Authors: Edurne Arriola, Ramón García Gómez, Pilar Diz, Margarita Majem, Maite Martínez Aguillo, Javier Valdivia, Alfredo Paredes, José Miguel Sánchez-Torres, Sergio Peralta Muñoz, Isidoro Barneto, Vanesa Gutierrez, Jesús Manuel Andrade Santiago, Francisco Aparisi, Dolores Isla, Santiago Ponce, David Vicente Baz…
    Citation: BMC Cancer 2018 18:106
    Content type: Research article Published on:

  26. Galectin-1, a radioresistance marker, was found in our previous study to be a prognostic factor for cervical cancer. The aim of current study is to determine the prognostic significance of the galectin-1 expre...

    Authors: Shang-Yu Chou, Shao-Lun Yen, Chao-Cheng Huang and Eng-Yen Huang
    Citation: BMC Cancer 2018 18:105
    Content type: Research article Published on:

  27. Breast cancer survivors are at high risk for fracture due to cancer treatment-induced bone loss, however, data is scarce regarding the scope of this problem from an epidemiologic and health services perspectiv...

    Authors: Evelyn Hsieh, Qin Wang, Renzhi Zhang, Xin Niu, Weibo Xia, Liana Fraenkel, Karl L. Insogna, Jing Li, Jennifer S. Smith, Chunwu Zhou, You-lin Qiao and Pin Zhang
    Citation: BMC Cancer 2018 18:104
    Content type: Research article Published on:

  28. The poor prognosis for glioblastoma patients is caused by the diffuse infiltrative growth pattern of the tumor. Therefore, the molecular and cellular processes underlying cell migration continue to be a major ...

    Authors: Tanja Eisemann, Barbara Costa, Jens Strelau, Michel Mittelbronn, Peter Angel and Heike Peterziel
    Citation: BMC Cancer 2018 18:103
    Content type: Technical advance Published on:

  29. Over time, the chance of cure after the diagnosis of breast cancer has been increasing, as a consequence of earlier diagnosis, improved diagnostic procedures and more effective treatment options. However, onco...

    Authors: Pierre Frères, Nassim Bouznad, Laurence Servais, Claire Josse, Stéphane Wenric, Aurélie Poncin, Jérôme Thiry, Marie Moonen, Cécile Oury, Patrizio Lancellotti, Vincent Bours and Guy Jerusalem
    Citation: BMC Cancer 2018 18:102
    Content type: Research article Published on:

  30. The prognosis of hepatocellular carcinoma with portal vein tumor thrombus remains extremely poor. This pilot study aimed to evaluate the technical feasibility, effectiveness and safety of transcatheter chemoem...

    Authors: Biao Yang, Chun-Lin Li, Wen-hao Guo, Tian-qiang Qin, He Jiao, Ze-jun Fei, Xuan Zhou, Lin-jia Duan and Zheng-yin Liao
    Citation: BMC Cancer 2018 18:101
    Content type: Research article Published on:

  31. Melanoma has two key features, an over-representation of UV-induced mutations and resistance to DNA damaging chemotherapy agents. Both of these features may result from dysfunction of the nucleotide excision r...

    Authors: Timothy Budden, Andre van der Westhuizen and Nikola A. Bowden
    Citation: BMC Cancer 2018 18:100
    Content type: Research article Published on:

  32. In menopausal women, one of the critical risk factors for breast cancer is obesity/adiposity. It is evident from various studies that leptin, a 16 kDa protein hormone overproduced in obese people, plays the cr...

    Authors: Inamul Haque, Arnab Ghosh, Seth Acup, Snigdha Banerjee, Kakali Dhar, Amitabha Ray, Sandipto Sarkar, Suman Kambhampati and Sushanta K. Banerjee
    Citation: BMC Cancer 2018 18:99
    Content type: Research article Published on:

  33. Few data are available regarding the treatment of metastatic colorectal cancer elderly patients with anti-EGFR agents in combination with chemotherapy. FOLFOX plus panitumumab is a standard first-line option for

    Authors: Francesca Battaglin, Marta Schirripa, Federica Buggin, Filippo Pietrantonio, Federica Morano, Giorgia Boscolo, Giuseppe Tonini, Eufemia Stefania Lutrino, Jessica Lucchetti, Lisa Salvatore, Alessandro Passardi, Chiara Cremolini, Ermenegildo Arnoldi, Mario Scartozzi, Nicoletta Pella, Luca Boni…
    Citation: BMC Cancer 2018 18:98
    Content type: Study protocol Published on:

  34. Herein, we report a complete response after whole brain radiotherapy (WBRT) and concomitant T-DM1 in a patient with HER2-positive metastatic breast cancer (MBC) and extensive brain and leptomeningeal involvement.

    Authors: Giuseppina Rosaria Rita Ricciardi, Alessandro Russo, Tindara Franchina, Silvia Schifano, Giampiero Mastroeni, Anna Santacaterina and Vincenzo Adamo
    Citation: BMC Cancer 2018 18:97
    Content type: Case report Published on:

  35. This study explores the effectiveness and cost-effectiveness of surveillance after breast cancer treatment provided in a hospital-setting versus surveillance embedded in the community-based National Breast Can...

    Authors: Kelly M. de Ligt, Annemieke Witteveen, Sabine Siesling and Lotte M. G. Steuten
    Citation: BMC Cancer 2018 18:96
    Content type: Research article Published on:

  36. Immune checkpoint blockade is developed as standard treatment for non-small cell lung cancer. However immune-related adverse events (irAE) have still unknown complications. Here, we report a patient with lung ...

    Authors: Yoshitsugu Narumi, Ryohei Yoshida, Yoshinori Minami, Yasushi Yamamoto, Shiori Takeguchi, Kohei Kano, Kae Takahashi, Tsukasa Saito, Jun Sawada, Hiroya Terui, Takayuki Katayama, Takaaki Sasaki and Yoshinobu Ohsaki
    Citation: BMC Cancer 2018 18:95
    Content type: Case report Published on:

  37. Surveys indicate quite high prevalence of cancer worry in the general population, but little is known about what it is about cancer that worries people. A better understanding of the origins of cancer worry ma...

    Authors: Philippa J. Murphy, Laura A. V. Marlow, Jo Waller and Charlotte Vrinten
    Citation: BMC Cancer 2018 18:86
    Content type: Research article Published on:

  38. TSP50 (testes-specific protease 50) has been reported to be a candidate oncogene and is overexpressed in various cancers. Our previous study demonstrated that TSP50 protein is elevated in gastric cancer, and i...

    Authors: Qing-Hua Cao, Fang Liu, Chang-Zhao Li, Ni Liu, Man Shu, Yuan Lin, Li Ding and Ling Xue
    Citation: BMC Cancer 2018 18:94
    Content type: Research article Published on:

  39. Deaf people represent 0.1% of the French population and their access to public health campaigns is limited due to their frequent illiteracy and the infrequent use of sign language in campaigns. There is also a...

    Authors: Vladimir Druel, Hélène Hayet, Laetitia Esman, Marie Clavel and Marie-Eve Rougé Bugat
    Citation: BMC Cancer 2018 18:93
    Content type: Research article Published on:

  40. Pazopanib is an oral tyrosine kinase inhibitor registered for metastatic renal cell carcinoma and soft tissue sarcoma. Liver toxicity is a common side effect for this class of agents. The current opinion is th...

    Authors: Arie J. Verschoor, Fabiënne A. R. M. Warmerdam, Tjalling Bosse, Judith V. M. G. Bovée and Hans Gelderblom
    Citation: BMC Cancer 2018 18:92
    Content type: Case report Published on:

  41. Women with a personal history of breast cancer are at increased risk of future breast cancer events, and may benefit from supplemental screening methods that could enhance early detection of subclinical diseas...

    Authors: Vivian Youngjean Park, Eun-Kyung Kim, Min Jung Kim, Hee Jung Moon and Jung Hyun Yoon
    Citation: BMC Cancer 2018 18:91
    Content type: Research article Published on:

  42. FAM3B/PANDER is a novel cytokine-like protein that induces apoptosis in insulin-secreting beta-cells. Since in silico data revealed that FAM3B can be expressed in prostate tumors, we evaluated the putative rol...

    Authors: Paula Maciel-Silva, Izabela Caldeira, Icaro de Assis Santos, Ana Claudia Oliveira Carreira, Flavia Ramos Siqueira, Eliane Antonioli, Anna Carla Goldberg, José Ernesto Belizário and Humberto Miguel Garay-Malpartida
    Citation: BMC Cancer 2018 18:90
    Content type: Research article Published on:

  43. One of the major challenges in soft tissue sarcomas is to identify factors that predict metastasis. AZGP1 is a potential biomarker of cancer progression, but its value in soft tissue sarcomas remains unknown. ...

    Authors: Jiayong Liu, Haibo Han, Zhengfu Fan, Marc El Beaino, Zhiwei Fang, Shu Li and Jiafu Ji
    Citation: BMC Cancer 2018 18:89
    Content type: Research article Published on:

  44. Scavenger receptor class B type I (SR-BI) has been reported to be involved in carcinogenesis of several human cancers. However, it is currently unknown whether SR-BI plays a role in clear cell renal cell carci...

    Authors: Guang-hua Xu, Ning Lou, Hang-chuan Shi, Yu-chen Xu, Hai-long Ruan, Wen Xiao, Lei Liu, Xiang Li, Hai-bing Xiao, Bin Qiu, Lin Bao, Chang-fei Yuan, Ya-li Zhou, Wen-jun Hu, Ke Chen, Hong-mei Yang…
    Citation: BMC Cancer 2018 18:88
    Content type: Research article Published on:

  45. Patients with highly mutated tumors, such as melanoma or smoking-related lung cancer, have higher rates of response to immune checkpoint blockade therapy, perhaps due to increased neoantigen expression. Many c...

    Authors: Timothy O’Donnell, Elizabeth L. Christie, Arun Ahuja, Jacqueline Buros, B. Arman Aksoy, David D. L. Bowtell, Alexandra Snyder and Jeff Hammerbacher
    Citation: BMC Cancer 2018 18:87
    Content type: Research article Published on:

  46. A unified analysis of DNA sequences from hundreds of tumors concluded that the driver mutations primarily occur in the earliest stages of cancer formation, with relatively few driver mutation events detected i...

    Authors: Karen Gomez, Sayaka Miura, Louise A. Huuki, Brianna S. Spell, Jeffrey P. Townsend and Sudhir Kumar
    Citation: BMC Cancer 2018 18:85
    Content type: Research article Published on:

  47. There is ongoing debate about the harms and benefits of a national prostate cancer screening programme. Several model-based cost-effectiveness analyses have been developed to determine whether the benefits of ...

    Authors: Sabina Sanghera, Joanna Coast, Richard M. Martin, Jenny L. Donovan and Syed Mohiuddin
    Citation: BMC Cancer 2018 18:84
    Content type: Research article Published on:

  48. We evaluated the incidence and spectrum of pathogenic and likely pathogenic variants of cancer susceptibility genes in BRCA1/2 mutation-negative Korean patients with a high risk for hereditary breast cancer using...

    Authors: Ji Soo Park, Seung-Tae Lee, Eun Ji Nam, Jung Woo Han, Jung-Yun Lee, Jieun Kim, Tae Il Kim and Hyung Seok Park
    Citation: BMC Cancer 2018 18:83
    Content type: Research article Published on:

  49. Side-effects have been considered as the limitation of the chemotherapy agents’ administration and life quality in patients with ovarian cancers. In order to explore the influence of the chemotherapy agents co...

    Authors: Yanxiu Guo, Haoxia Zeng, Xiaohong Chang, Chaohua Wang and Heng Cui
    Citation: BMC Cancer 2018 18:81
    Content type: Research article Published on:

  50. After publication of the original article [1] the authors found that the article contained an incorrect version of Fig. 4. This does not affect the results and conclusions of the article.

    Authors: Fatemeh Kaveh, Lars O. Baumbusch, Daniel Nebdal, Anne-Lise Børresen-Dale, Ole Christian Lingjærde, Hege Edvardsen, Vessela N. Kristensen and Hiroko K. Solvang
    Citation: BMC Cancer 2018 18:80
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2016 16:913

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