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  1. In addition to tumor characteristics and lifestyle factors, cancer relapses are often related to the risk of death but have not been jointly studied. We investigate the prognostic factors of recurrent events a...

    Authors: Alexandre Lafourcade, Mathilde His, Laura Baglietto, Marie-Christine Boutron-Ruault, Laure Dossus and Virginie Rondeau
    Citation: BMC Cancer 2018 18:171
    Content type: Research article Published on:

  2. Breast cancer is considered the most common cancer in women worldwide and is the leading cause of cancer mortality. Sequences similar to Mouse Mammary Tumor Virus (MMTV) were detected in human breast cancer in...

    Authors: Reem Al Dossary, Khaled R. Alkharsah and Haitham Kussaibi
    Citation: BMC Cancer 2018 18:170
    Content type: Research article Published on:

  3. Estimates of cancer prevalence are widely based on limited duration, often including patients living after a cancer diagnosis made in the previous 5 years and less frequently on complete prevalence (i.e., incl...

    Authors: Stefano Guzzinati, Saverio Virdone, Roberta De Angelis, Chiara Panato, Carlotta Buzzoni, Riccardo Capocaccia, Silvia Francisci, Anna Gigli, Manuel Zorzi, Giovanna Tagliabue, Diego Serraino, Fabio Falcini, Claudia Casella, Antonio Giampiero Russo, Fabrizio Stracci, Bianca Caruso…
    Citation: BMC Cancer 2018 18:169
    Content type: Research article Published on:

  4. The phosphoinositide-3-kinase (PI3K) pathway is the most commonly activated pathway in cancers due to mutations at multiple nodes and loss of PTEN. Furthermore, in endometrial cancer (EC), PI3K and RAS/RAF/MEK...

    Authors: Ozlem Aslan, Mattia Cremona, Clare Morgan, Lydia W. Cheung, Gordon B. Mills and Bryan T. Hennessy
    Citation: BMC Cancer 2018 18:168
    Content type: Research article Published on:

  5. Tumour cells have a high demand for arginine. However, a subset of glioblastomas has a defect in the arginine biosynthetic pathway due to epigenetic silencing of the rate limiting enzyme argininosuccinate synt...

    Authors: Lina Mörén, Richard Perryman, Tim Crook, Julia K. Langer, Kevin Oneill, Nelofer Syed and Henrik Antti
    Citation: BMC Cancer 2018 18:167
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2018 18:268

  6. Oropharyngeal Squamous Cell Carcinoma (OPSCC) is increasing in incidence despite a decline in traditional risk factors. Human Papilloma Virus (HPV), specifically subtypes 16, 18, 31 and 35, has been implicated...

    Authors: Mitchell G. Rohatensky, Devon M. Livingstone, Paul Mintchev, Heather K. Barnes, Steven C. Nakoneshny, Douglas J. Demetrick, Joseph C. Dort and Guido van Marle
    Citation: BMC Cancer 2018 18:166
    Content type: Research article Published on:

  7. Breast cancer risk for BRCA1 and BRCA2 pathogenic mutation carriers is modified by risk factors that cluster in families, including genetic modifiers of risk. We considered genetic modifiers of risk for carriers ...

    Authors: Tú Nguyen-Dumont, Zhi L. Teo, Fleur Hammet, Alexis Roberge, Maryam Mahmoodi, Helen Tsimiklis, Daniel J. Park, Bernard J. Pope, Andrew Lonie, Miroslav K. Kapuscinski, Khalid Mahmood, David E. Goldgar, Graham G. Giles, Ingrid Winship, John L. Hopper and Melissa C. Southey
    Citation: BMC Cancer 2018 18:165
    Content type: Research article Published on:

  8. Vascular supply of tumors is one of the main targets for cancer therapy. Here, we investigated if plocabulin (PM060184), a novel marine-derived microtubule-binding agent, presents antiangiogenic and vascular-d...

    Authors: Carlos M. Galmarini, Maud Martin, Benjamin Pierre Bouchet, María José Guillen-Navarro, Marta Martínez-Diez, Juan Fernando Martinez-Leal, Anna Akhmanova and Pablo Aviles
    Citation: BMC Cancer 2018 18:164
    Content type: Research article Published on:

  9. An increasing incidence of thyroid cancer is observed in many developed countries. Increasing incidence may also reflect better reporting or increased diagnostic scrutiny. We conducted this study to examine tr...

    Authors: Umesh Jayarajah, Ashan Fernando, Saumyakala Prabashani, Eshani A. Fernando and Sanjeewa A. Seneviratne
    Citation: BMC Cancer 2018 18:163
    Content type: Research article Published on:

  10. The present study (1) examined patient satisfaction with care over the first year following the diagnosis of advanced breast cancer and (2) tested if unmet health system and information needs, physical symptom...

    Authors: Wendy W. T. Lam, Ava Kwong, Dacita Suen, Janice Tsang, Inda Soong, Tze Kok Yau, Winnie Yeo, Joyce Suen, Wing Ming Ho, Ka Yan Wong, Wing Kin Sze, Alice W. Y. Ng and Richard Fielding
    Citation: BMC Cancer 2018 18:162
    Content type: Research article Published on:

  11. The incidence and incidence trends of breast cancer according to molecular subtype are unknown at a population level in France. The registry data enables this study and may give this information, that is cruci...

    Authors: Marion Cortet, Aurélie Bertaut, Florence Molinié, Simona Bara, Françoise Beltjens, Charles Coutant and Patrick Arveux
    Citation: BMC Cancer 2018 18:161
    Content type: Research article Published on:

  12. Inconsistent associations between smoking status and prostate cancer (PC) could be due to exposure assessment error. Reconstructing smoking behaviors over the life course could reduce exposure assessment error.

    Authors: Evelyn Jiménez-Mendoza, Ruth A. Vázquez-Salas, Tonatiuh Barrientos-Gutierrez, Luz Myriam Reynales-Shigematsu, Isaac Roberto Labra-Salgado, Hugo A. Manzanilla-García and Luisa E. Torres-Sánchez
    Citation: BMC Cancer 2018 18:160
    Content type: Research article Published on:

  13. To clarify the effect of anaesthetic agents on cancer immunity, we evaluated the effects of propofol and sevoflurane on natural killer (NK) cell, cytotoxic T lymphocyte (CTL) counts and apoptosis rate in breas...

    Authors: Jeong-Ae Lim, Chung-Sik Oh, Tae-Gyoon Yoon, Ji Yeon Lee, Seung-Hyun Lee, Young-Bum Yoo, Jung-Hyun Yang and Seong-Hyop Kim
    Citation: BMC Cancer 2018 18:159
    Content type: Research article Published on:

  14. Polycomb repressive complex 2 (PRC2; formed by EZH2, SUZ12, and EED protein subunits) and PRC1 (BMI1 protein) induce gene silencing through histone modification by H3K27me3. In the present study, we characteri...

    Authors: Yong Jin Cho, Soo Hee Kim, Eun Kyung Kim, Jung Woo Han, Kyoo-Ho Shin, Hyuk Hu, Kyung Sik Kim, Young Deuk Choi, Sunghoon Kim, Young Han Lee, Jin-Suck Suh, Joong Bae Ahn, Hyun Cheol Chung, Sung Hoon Noh, Sun Young Rha, Sung-Taek Jung…
    Citation: BMC Cancer 2018 18:158
    Content type: Research article Published on:

  15. Diethylnitrosamine is a well known carcinogen that induces cancers of various organs in mice and rats. Using FVB/N mouse strain, here we show that diethylnitrosamine induces primarily lung adenocarcinomas with...

    Authors: Zsolt Mervai, Krisztina Egedi, Ilona Kovalszky and Kornélia Baghy
    Citation: BMC Cancer 2018 18:157
    Content type: Research article Published on:

  16. Programmed death-1 ligand-1 (PD-L1) an important cancer biomarker that can suppress the immune system and its high expression is often reported to be related with increased tumor aggressiveness in some cancers...

    Authors: Koji Harada, Tarannum Ferdous and Yoshiya Ueyama
    Citation: BMC Cancer 2018 18:156
    Content type: Research article Published on:

  17. The rs2282679 A>C polymorphism in the vitamin D binding protein gene is associated with lower circulating levels of vitamin D. We investigated associations of this SNP with colorectal cancer (CRC) risk and sur...

    Authors: Yun Zhu, Peizhong Peter Wang, Guangju Zhai, Bharati Bapat, Sevtap Savas, Jennifer R. Woodrow, Peter T. Campbell, Yuming Li, Ning Yang, Xin Zhou, Elizabeth Dicks, John R. Mclaughlin and Patrick S. Parfrey
    Citation: BMC Cancer 2018 18:155
    Content type: Research article Published on:

  18. Glioblastoma (GBM) is the most common malignant brain tumor with median survival of 12-15 months. Owing to uncertainty in clinical outcome, additional prognostic marker(s) apart from existing markers are neede...

    Authors: Suhas Vasaikar, Giorgos Tsipras, Natalia Landázuri, Helena Costa, Vanessa Wilhelmi, Patrick Scicluna, Huanhuan L. Cui, Abdul-Aleem Mohammad, Belghis Davoudi, Mingmei Shang, Sharan Ananthaseshan, Klas Strååt, Giuseppe Stragliotto, Afsar Rahbar, Kum Thong Wong, Jesper Tegner…
    Citation: BMC Cancer 2018 18:154
    Content type: Research article Published on:

  19. The UDP-glucose ceramide glycosyltransferase (UGCG) is a key enzyme in the sphingolipid metabolism by generating glucosylceramide (GlcCer), the precursor for all glycosphingolipids (GSL), which are essential f...

    Authors: Marthe-Susanna Wegner, Lisa Gruber, Peter Mattjus, Gerd Geisslinger and Sabine Grösch
    Citation: BMC Cancer 2018 18:153
    Content type: Debate Published on:

  21. The association between body mass index (BMI) and clinical outcomes of gastric cancer were still under debate. The aim of the present study was to investigate the impact of BMI on intraoperative conditions, po...

    Authors: Fan Feng, Gaozan Zheng, Xiaohua Guo, Zhen Liu, Guanghui Xu, Fei Wang, Qiao Wang, Man Guo, Xiao Lian and Hongwei Zhang
    Citation: BMC Cancer 2018 18:151
    Content type: Research article Published on:

  22. We investigated the effect of arsenic trioxide (ATO) for inhibition of signal transducer and activator of transcription 3 (STAT3) and epithelial-mesenchymal transition (EMT) in gastric cancer cells, and the ro...

    Authors: Sung Ho Kim, Hyo Soon Yoo, Moon Kyung Joo, Taehyun Kim, Jong-Jae Park, Beom Jae Lee, Hoon Jai Chun, Sang Woo Lee and Young-Tae Bak
    Citation: BMC Cancer 2018 18:150
    Content type: Research article Published on:

  23. Pancreas ductal adenocarcinoma (PDAC) has the most dismal prognosis among all human cancers since it is highly resistant to chemotherapy, radiotherapy and immunotherapy. The anticipated consequence of all ther...

    Authors: Chunwan Lu, Dafeng Yang, Maria E. Sabbatini, Aaron H. Colby, Mark W. Grinstaff, Nicholas H. Oberlies, Cedric Pearce and Kebin Liu
    Citation: BMC Cancer 2018 18:149
    Content type: Research article Published on:

  24. Although EGFR-TKI is the preferred treatment for NSCLC patients with sensitive mutations, subsequent drug resistance is almost inevitable. The specific mechanisms of EGFR-TKI drug resistance can be identified ...

    Authors: Zan-Feng Wang, Sheng-Xiang Ren, Wei Li and Guang-Hui Gao
    Citation: BMC Cancer 2018 18:148
    Content type: Research article Published on:

  25. Increasing evidence shows that dysregulated long non-coding RNAs (lncRNAs) can serve as potential biomarkers for cancer prognosis. However, lncRNA signatures, as potential prognostic biomarkers for esophageal ...

    Authors: Guo-Wei Huang, Yu-Jie Xue, Zhi-Yong Wu, Xiu-E Xu, Jian-Yi Wu, Hui-Hui Cao, Ying Zhu, Jian-Zhong He, Chun-Quan Li, En-Min Li and Li-Yan Xu
    Citation: BMC Cancer 2018 18:147
    Content type: Research article Published on:

  26. Metastases to the thyroid gland are more frequent than previously thought, although most of them are occult or not clinically relevant. Overall, only 42 cases of metastases to thyroid from breast cancer have b...

    Authors: Matilde Pensabene, Brigida Stanzione, Ivana Cerillo, Giuseppe Ciancia, Immacolata Cozzolino, Raffaella Ruocco, Caterina Condello, Giuseppe Di Lorenzo, Mario Giuliano, Valeria Forestieri, Grazia Arpino, Sabino De Placido and Rossella Lauria
    Citation: BMC Cancer 2018 18:146
    Content type: Case report Published on:

  27. Immunotherapies have advanced the treatment of metastatic melanoma; however, they are associated with immune-related toxicities. Patients with pre-existing autoimmune comorbidities are commonly excluded from c...

    Authors: Qiufei Ma, Mark Shilkrut, Zhongyun Zhao, Minming Li, Nicolas Batty and Beth Barber
    Citation: BMC Cancer 2018 18:145
    Content type: Research article Published on:

  28. Limited data are available regarding the ability of biomarkers to predict complete pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. Complete response translates to bett...

    Authors: J. Martinez-Useros, I. Moreno, M. J. Fernandez-Aceñero, M. Rodriguez-Remirez, A. Borrero-Palacios, A. Cebrian, T. Gomez del Pulgar, L. del Puerto-Nevado, W. Li, A. Puime-Otin, N. Perez, M. S. Soengas and J. Garcia-Foncillas
    Citation: BMC Cancer 2018 18:144
    Content type: Research article Published on:

  29. HtrA1 is expressed in a variety of normal human tissues and seems to be involved in numerous physiological processes as well as tumorigenesis. This study reports the results of a meta-analysis that was perform...

    Authors: Emma Altobelli, Paolo Matteo Angeletti, Manrico Morroni and Valerio Filippo Profeta
    Citation: BMC Cancer 2018 18:143
    Content type: Research article Published on:

  30. Neoadjuvant chemoradiotherapy (nCRT) plus surgery is a standard treatment for locally advanced oesophageal cancer. With this treatment, 29% of patients have a pathologically complete response in the resection ...

    Authors: Bo Jan Noordman, Bas P. L. Wijnhoven, Sjoerd M. Lagarde, Jurjen J. Boonstra, Peter Paul L. O. Coene, Jan Willem T. Dekker, Michael Doukas, Ate van der Gaast, Joos Heisterkamp, Ewout A. Kouwenhoven, Grard A. P. Nieuwenhuijzen, Jean-Pierre E. N. Pierie, Camiel Rosman, Johanna W. van Sandick, Maurice J. C. van der Sangen, Meindert N. Sosef…
    Citation: BMC Cancer 2018 18:142
    Content type: Study protocol Published on:

    The Update to this article has been published in Trials 2021 22:345

  31. microRNAs (miRNAs) are considered promising cancer biomarkers, showing high reliability, sensitivity and stability. Our study aimed to identify associations between whole blood miRNA profiles, presence of circ...

    Authors: Marianna Alunni-Fabbroni, Leonie Majunke, Elisabeth K. Trapp, Marie Tzschaschel, Sven Mahner, Peter A. Fasching, Tanja Fehm, Andreas Schneeweiss, Thomas Beck, Ralf Lorenz, Thomas W. P. Friedl, Wolfgang Janni and Brigitte Rack
    Citation: BMC Cancer 2018 18:141
    Content type: Research article Published on:

  32. Colorectal cancer (CRC) is the fourth leading cause of cancer related deaths worldwide and prognosis in advanced tumor stage still remains poor. Since CK1 isoforms have been reported to be deregulated in sever...

    Authors: Julia Richter, Anna-Laura Kretz, Johannes Lemke, Michael Fauler, Jens-Uwe Werner, Stephan Paschke, Frank Leithäuser, Doris Henne-Bruns, Andreas Hillenbrand and Uwe Knippschild
    Citation: BMC Cancer 2018 18:140
    Content type: Research article Published on:

  33. While the incidence of esophageal and gastric cancers is increasing, the prognosis of these cancers remains bleak. Endoscopy and surgery are the standard treatments for localized tumors, but multimodal treatme...

    Authors: Christophe Mariette, Florence Renaud, Guillaume Piessen, Patrick Gele, Marie-Christine Copin, Emmanuelle Leteurtre, Christine Delaeter, Malek Dib, Stéphanie Clisant, Valentin Harter, Franck Bonnetain, Alain Duhamel, Véronique Christophe and Antoine Adenis
    Citation: BMC Cancer 2018 18:139
    Content type: Study protocol Published on:

  34. Depression is highly prevalent yet often poorly detected and treated among cancer patients. In light of the move towards evidence-based healthcare policy, we have developed a simple tool that can assist policy...

    Authors: Robert W. Sanson-Fisher, Natasha E. Noble, Andrew M. Searles, Simon Deeming, Rochelle E. Smits, Christopher J. Oldmeadow and Jamie Bryant
    Citation: BMC Cancer 2018 18:125
    Content type: Research article Published on:

  35. Quality of life has an important place in the future of patients with breast cancer. The objective of this study is to assess the evolution of the patient’s quality of life with breast cancer in Morocco after ...

    Authors: B. M. Traore, S. El Fakir, H. Charaka, N. Benaicha, A. Najdi, A. Zidouh, M. Bennani, H. Errihani, N. Mellass, A. Benider, R. Bekkali and C. Nejjari
    Citation: BMC Cancer 2018 18:109
    Content type: Research article Published on:

  36. Regorafenib is a multi-kinase inhibitor, which was shown to be effective for patients with metastatic colorectal cancer refractory to standard therapies. However, its patterns of response has not yet been full...

    Authors: Yukinori Ozaki, Junichi Shindoh, Wataru Gonoi, Yujiro Nishioka, Chihiro Kondoh, Yuko Tanabe, Shuichiro Matoba, Hiroya Kuroyanagi, Masaji Hashimoto and Toshimi Takano
    Citation: BMC Cancer 2018 18:138
    Content type: Research article Published on:

  37. Despite the recent changes in the treatment of the axilla in selected breast cancer patient, positive sentinel lymph node (SLN) in patients undergoing mastectomy still necessitates axillary lymph node dissecti...

    Authors: Jerica Novak, Nikola Besic, Radan Dzodic, Barbara Gazic and Andrej Vogrin
    Citation: BMC Cancer 2018 18:137
    Content type: Research article Published on:

  38. Polo-like kinase 1 (Plk1) is a serine/threonine kinase that is a key regulator of multiple stages of mitotic progression. Plk1 is upregulated in many tumor types including colorectal cancer (CRC) and portends ...

    Authors: Peter J. Klauck, Stacey M. Bagby, Anna Capasso, Erica L. Bradshaw-Pierce, Heather M. Selby, Anna Spreafico, John J. Tentler, Aik Choon Tan, Jihye Kim, John J. Arcaroli, Alicia Purkey, Wells A. Messersmith, Keisuke Kuida, S. Gail Eckhardt and Todd M. Pitts
    Citation: BMC Cancer 2018 18:136
    Content type: Research article Published on:

  39. We evaluated treatment decisions and outcomes in a cohort of predominately Caucasian patients with EGFR mutation-positive (EGFR Mut+) non-small-cell lung cancer (NSCLC).

    Authors: Wolfgang Schuette, Peter Schirmacher, Wilfried E. E. Eberhardt, Manfred Dietel, Ute Zirrgiebel, Lars Muehlenhoff and Michael Thomas
    Citation: BMC Cancer 2018 18:135
    Content type: Research article Published on:

  40. Extra-uterine mullerian adenosarcomas have varying biological behaviours depending on the presence of endometriosis or sarcomatous overgrowth. These behaviours manifest according to the tumours’ histological c...

    Authors: Vincenzo Dario Mandato, Federica Torricelli, Valentina Mastrofilippo, Riccardo Valli, Lorenzo Aguzzoli and Giovanni Battista La Sala
    Citation: BMC Cancer 2018 18:134
    Content type: Case report Published on:

  42. Due to the ageing population and improving diagnostics and treatments, the number of cancer patients and cancer survivors is increasing. Policymakers, patients and professionals advocate a transfer of (part of...

    Authors: I. A. A. Perfors, C. W. Helsper, E. A. Noteboom, E. van der Wall, N. J. de Wit and A. M. May
    Citation: BMC Cancer 2018 18:132
    Content type: Study protocol Published on:

  43. It has been suggested that distal gastric carcinoma (GC) in younger patients has a more aggressive outcome than in older patients, however this is a controversial issue. The aim of this study was to compare cl...

    Authors: Manuel B. Braga-Neto, Jessica Gomes Carneiro, Alzira M. de Castro Barbosa, Igor S. Silva, Danielle C. Maia, Felipe S. Maciel, Rafael Jorge Alves de Alcântara, Paulo Roberto L. Vasconscelos and Lucia L. B. C. Braga
    Citation: BMC Cancer 2018 18:131
    Content type: Research article Published on:

  44. The heterogeneous behavior of patients with melanoma makes prognostication challenging. To address this, a gene expression profile (GEP) test to predict metastatic risk was previously developed. This study eva...

    Authors: Jonathan S. Zager, Brian R. Gastman, Sancy Leachman, Rene C. Gonzalez, Martin D. Fleming, Laura K. Ferris, Jonhan Ho, Alexander R. Miller, Robert W. Cook, Kyle R. Covington, Kristen Meldi-Plasseraud, Brooke Middlebrook, Lewis H. Kaminester, Anthony Greisinger, Sarah I. Estrada, David M. Pariser…
    Citation: BMC Cancer 2018 18:130
    Content type: Research article Published on:

  45. Tumour-infiltrating lymphocytes (TILs) have been demonstrated to significantly influence prognosis and response to therapy of invasive breast cancer (IBC). Thus, it has been suggested that TIL density or/and i...

    Authors: Marie Beguinot, Marie-Melanie Dauplat, Fabrice Kwiatkowski, Guillaume Lebouedec, Lucie Tixier, Christophe Pomel, Frederique Penault-Llorca and Nina Radosevic-Robin
    Citation: BMC Cancer 2018 18:129
    Content type: Research article Published on:

  46. Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a candidate diagnostic and prognostic biomarker for pancreatic ductal adenocarcinoma (PDAC). Here, we determined the possible association of systemic TIMP-1...

    Authors: Olga Prokopchuk, Barbara Grünwald, Ulrich Nitsche, Carsten Jäger, Oleksii L. Prokopchuk, Elaine C. Schubert, Helmut Friess, Marc E. Martignoni and Achim Krüger
    Citation: BMC Cancer 2018 18:128
    Content type: Research article Published on:

  47. Nc886 is a 102 bp non-coding RNA transcript initially classified as a microRNA precursor (Pre-miR-886), later as a divergent homologue of the vault RNAs (vtRNA 2–1) and more recently as a novel type of RNA (nc...

    Authors: Rafael Sebastián Fort, Cecilia Mathó, Murilo Vieira Geraldo, María Carolina Ottati, Alex Shimura Yamashita, Kelly Cristina Saito, Katia Ramos Moreira Leite, Manuel Méndez, Noemí Maedo, Laura Méndez, Beatriz Garat, Edna Teruko Kimura, José Roberto Sotelo-Silveira and María Ana Duhagon
    Citation: BMC Cancer 2018 18:127
    Content type: Research article Published on:

  48. Quality indicators for the Brazilian cervical cancer screening programme can provide a perspective on its effectiveness in Brazilian macro-regions and states. The aim of this study was to perform a trend analy...

    Authors: Ricardo Filipe Alves Costa, Adhemar Longatto-Filho, Fabiana de Lima Vazquez, Céline Pinheiro, Luiz Carlos Zeferino and José Humberto Tavares Guerreiro Fregnani
    Citation: BMC Cancer 2018 18:126
    Content type: Research article Published on:

  49. Patients with primary brain tumors are reported to have an elevated level of distress prevalence, due to the functional sequelae and the unfavorable prognosis, but the estimated prevalence of this disorder var...

    Authors: Fangkun Liu, Jing Huang, Liyang Zhang, Fan Fan, Jindong Chen, Kun Xia and Zhixiong Liu
    Citation: BMC Cancer 2018 18:124
    Content type: Research article Published on:

  50. The tumour microenvironment consists of malignant cells, stroma and immune cells. In women with large and locally advanced breast cancers (LLABCs) undergoing neoadjuvant chemotherapy (NAC), tumour-infiltrating...

    Authors: Viriya Kaewkangsadan, Chandan Verma, Jennifer M. Eremin, Gerard Cowley, Mohammad Ilyas and Oleg Eremin
    Citation: BMC Cancer 2018 18:123
    Content type: Research article Published on:

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