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  1. The consequences of treatment for Head and Neck cancer (HNC) patients has profound detrimental impacts such as impaired QOL, emotional distress, delayed recovery and frequent use of healthcare. The aim of this...

    Authors: Simon N. Rogers, Derek Lowe, Cher Lowies, Seow Tien Yeo, Christine Allmark, Dominic Mcavery, Gerald M. Humphris, Robert Flavel, Cherith Semple, Steven J. Thomas and Anastasios Kanatas
    Citation: BMC Cancer 2018 18:444
    Content type: Study protocol Published on:

  2. Patients with recurrent malignant epithelioid mesothelioma (MM) after surgery and standard chemotherapy with cisplatin and pemetrexed have limited treatment options.

    Authors: Urs Giger-Pabst, Cédric Demtröder, Thomas A. Falkenstein, Mehdi Ouaissi, Thorsten O. Götze, Günther A. Rezniczek and Clemens B. Tempfer
    Citation: BMC Cancer 2018 18:442
    Content type: Research article Published on:

  3. Survival rates for upper gastrointestinal (GI) cancer are poor since many are diagnosed at advanced stages. Fast track endoscopy has been introduced to prompt diagnosis for patients with alarm symptoms that co...

    Authors: Sanne Rasmussen, Peter Fentz Haastrup, Kirubakaran Balasubramaniam, René DePont Christensen, Jens Søndergaard and Dorte Ejg Jarbøl
    Citation: BMC Cancer 2018 18:440
    Content type: Research article Published on:

  4. Several studies in the past have investigated the expression of micro RNAs (miRNAs) in saliva as potential biomarkers. Since miRNAs associated with extracellular vesicles (EVs) are known to be protected from e...

    Authors: Chiara Gai, Francesco Camussi, Roberto Broccoletti, Alessio Gambino, Marco Cabras, Luca Molinaro, Stefano Carossa, Giovanni Camussi and Paolo G. Arduino
    Citation: BMC Cancer 2018 18:439
    Content type: Research article Published on:

  5. Previous studies have suggested that metformin may be useful for preventing and treating endometrial cancer (EC), while the results have been inconsistent. This systematic review and meta-analysis aimed to inv...

    Authors: Danxia Chu, Jie Wu, Kaili Wang, Mengling Zhao, Chunfang Wang, Liuxia Li and Ruixia Guo
    Citation: BMC Cancer 2018 18:438
    Content type: Research article Published on:

  6. It has been highlighted that the original manuscript [1] contains a typesetting error in Fig. 1 and the Fig. 1c panel gas been inadvertently duplicated in panel Fig. 1d. This does not affect the results and co...

    Authors: Lee-Hwa Tai, Abhirami A. Ananth, Rashmi Seth, Almohanad Alkayyal, Jiqing Zhang, Christiano Tanese de Souza, Phillip Staibano, Michael A. Kennedy and Rebecca C. Auer
    Citation: BMC Cancer 2018 18:437
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2018 18:277

  7. Our previous study demonstrated a close relationship between NOTCH signaling pathway and salivary adenoid cystic carcinoma (SACC). HES1 is a well-known target gene of NOTCH signaling pathway. The purpose of th...

    Authors: Xiao-Yu Huang, Rui-Huan Gan, Jian Xie, Lin She, Yong Zhao, Lin-Can Ding, Bo-Hua Su, Da-Li Zheng and You-Guang Lu
    Citation: BMC Cancer 2018 18:436
    Content type: Research article Published on:

  8. In China, stomach cancer is the third most common cancer and the third leading cause of cancer death. Few studies have examined Chinese stomach cancer patients’ medical expenses and their associated trends. Th...

    Authors: Xiao-Jie Sun, Ju-Fang Shi, Lan-Wei Guo, Hui-Yao Huang, Neng-Liang Yao, Ji-Yong Gong, Ya-Wen Sun, Guo-Xiang Liu, A-Yan Mao, Xian-Zhen Liao, Ya-Na Bai, Jian-Song Ren, Xin-Yu Zhu, Jin-Yi Zhou, Ling Mai, Bing-Bing Song…
    Citation: BMC Cancer 2018 18:435
    Content type: Research article Published on:

  9. Metformin (Met) is a widely available diabetic drug and shows suppressed effects on renal cell carcinoma (RCC) metabolism and proliferation. Laboratory studies in RCC suggested that metformin has remarkable an...

    Authors: Muyun Wei, Shaowei Mao, Guoliang Lu, Liang Li, Xiaopeng Lan, Zhongxian Huang, Yougen Chen, Miaoqing Zhao, Yueran Zhao and Qinghua Xia
    Citation: BMC Cancer 2018 18:434
    Content type: Research article Published on:

  11. Multiple trials have attempted to demonstrate the effective induction of cell death in TRAIL-resistant cancer cells, including using a combined treatment of recombinant TRAIL and various proteasome inhibitors....

    Authors: Sunhyo Ryu, Yun Jeong Ahn, Chakeong Yoon, Jeong Hwan Chang, Yoonkyung Park, Tae-Hyoung Kim, Amanda R. Howland, Cheryl A. Armstrong, Peter I. Song and Ae Ran Moon
    Citation: BMC Cancer 2018 18:432
    Content type: Research article Published on:

  12. In various cancers, overexpression of cyclooxygenase (COX)-2 and elevated prostaglandin (PG) E2 synthesis have been associated with tumor development and progression. The potential of COX-2 inhibitors in cance...

    Authors: Anna Semmlinger, Viktoria von Schoenfeldt, Verena Wolf, Alexandra Meuter, Theresa Maria Kolben, Thomas Kolben, Christine Zeder-Goess, Florian Weis, Julia Gallwas, Rachel Wuerstlein, Kerstin Hermelink, Elisa Schmoeckel, Nadia Harbeck, Doris Mayr, Sven Mahner, Udo Jeschke…
    Citation: BMC Cancer 2018 18:431
    Content type: Research article Published on:

  13. Precursor T-cell lymphoblastic lymphomas (T-LBL) are rare aggressive hematological malignancies that mainly develop in children. As in other cancers, the loss of cell cycle control plays a prominent role in th...

    Authors: Pilar López-Nieva, Pablo Fernández-Navarro, Concepción Vaquero-Lorenzo, María Villa-Morales, Osvaldo Graña-Castro, María Ángeles Cobos-Fernández, José Luis López-Lorenzo, Pilar Llamas, Laura González-Sanchez, Isabel Sastre, Marina Pollan, Marcos Malumbres, Javier Santos and José Fernández-Piqueras
    Citation: BMC Cancer 2018 18:430
    Content type: Research article Published on:

  14. The relapse rate in early stage non-small cell lung cancer (NSCLC) after surgical resection is high. Prognostic biomarkers may help identify patients who may benefit from additional therapy. The Helicase-like ...

    Authors: Ludovic Dhont, Melania Pintilie, Ethan Kaufman, Roya Navab, Shirley Tam, Arsène Burny, Frances Shepherd, Alexandra Belayew, Ming-Sound Tsao and Céline Mascaux
    Citation: BMC Cancer 2018 18:429
    Content type: Research article Published on:

  15. We aimed to investigate the roles of hemoglobin (Hb) concentrations and dynamic change during treatment on outcomes of patients with extremity osteosarcoma.

    Authors: Jian Tu, Lili Wen, Zijun Huo, Bo Wang, Yongqian Wang, Hongyi Liao, Weihai Liu, Xian Zhong, Jianqiu Kong, Mengqi Wang, Gang Huang, Junqiang Yin, Xianbiao Xie and Jingnan Shen
    Citation: BMC Cancer 2018 18:428
    Content type: Research article Published on:

  16. The prognosis of patients with pathologic stage T3a renal cell carcinoma (RCC) that is up-staged from a small renal tumor remains controversial. We evaluated the prognosis of patients with RCC who were up-stag...

    Authors: Hakmin Lee, Minseung Lee, Sang Eun Lee, Seok-Soo Byun, Hyeon Hoe Kim, Cheol Kwak and Sung Kyu Hong
    Citation: BMC Cancer 2018 18:427
    Content type: Research article Published on:

  17. Ovarian cancer is one of the most deadly gynecological malignancies and inclined to recurrence and drug resistance. Previous studies showed that the tumorigenesis of ovarian cancers and their major histotypes ...

    Authors: Zizhi Tang, Juan Yang, Xin Wang, Ming Zeng, Jing Wang, Ao Wang, Mingcai Zhao, Liandi Guo, Cong Liu, Dehua Li and Jie Chen
    Citation: BMC Cancer 2018 18:426
    Content type: Research article Published on:

  18. Ovarian carcinoma (OC) is the fifth most common female cancer and mostly diagnosed at an advanced stage. Surgical debulking is usually followed by adjuvant platinum-based chemotherapy. Only few biomarkers are ...

    Authors: Michaela Ramser, Simone Eichelberger, Silvio Däster, Benjamin Weixler, Marko Kraljević, Robert Mechera, Athanasios Tampakis, Tarik Delko, Uwe Güth, Sylvia Stadlmann, Luigi Terracciano, Raoul A. Droeser and Gad Singer
    Citation: BMC Cancer 2018 18:425
    Content type: Research article Published on:

  19. The Sarcoma Policy Checklist was created by a multidisciplinary expert group to provide policymakers with priority areas to improve care for sarcoma patients.

    Authors: Bernd Kasper, Estelle Lecointe-Artzner, Suzanne Wait, Shannon Boldon, Roger Wilson, Alessandro Gronchi, Claudia Valverde, Mikael Eriksson, Sarah Dumont, Nora Drove, Athanasia Kanli and Markus Wartenberg
    Citation: BMC Cancer 2018 18:424
    Content type: Debate Published on:

  20. Targeted therapies are based on exploiting cancer-cell-specific genetic features or phenotypic traits to selectively kill cancer cells while leaving normal cells unaffected. Oxidative stress is a cancer hallma...

    Authors: Hussein H. K. Abbas, Kheloud M. H. Alhamoudi, Mark D. Evans, George D. D. Jones and Steven S. Foster
    Citation: BMC Cancer 2018 18:423
    Content type: Research article Published on:

  21. The increasing epidemic proportions of diabetes mellitus (DM) are a major cause of premature illness and death. However, whether DM confers the same excess risk of gastrointestinal cancer for women as it does ...

    Authors: Hong-juan FANG, Shao-bo SHAN, Yu-hao ZHOU and Li-yong ZHONG
    Citation: BMC Cancer 2018 18:422
    Content type: Research article Published on:

  22. Dysregulation of microRNA (miRNA) expression is associated with hallmarks of aggressive tumor phenotypes, e.g., enhanced cell growth, proliferation, invasion, and anchorage independent growth in prostate cance...

    Authors: Dominique Z. Jones, M. Lee Schmidt, Suman Suman, Katharine R. Hobbing, Shirish S. Barve, Leila Gobejishvili, Guy Brock, Carolyn M. Klinge, Shesh N. Rai, Jong Park, Geoffrey J. Clark, Rajesh Agarwal and LaCreis R. Kidd
    Citation: BMC Cancer 2018 18:421
    Content type: Research article Published on:

  23. Patients with the myeloproliferative neoplasms (MPNs) myelofibrosis (MF), polycythemia vera (PV), and essential thrombocythemia (ET) are at increased risk for thrombotic and cardiovascular events and experienc...

    Authors: Jingbo Yu, Shreekant Parasuraman, Dilan Paranagama, Andrew Bai, Ahmad Naim, David Dubinski and Ruben Mesa
    Citation: BMC Cancer 2018 18:420
    Content type: Research article Published on:

  24. Kruppel family member zinc binding protein 89 (ZBP-89), also known as ZNF148, regulates Bak expression via binding to GC-rich promoter domain. It is not clear if other GC-rich binding factors, such as Sp famil...

    Authors: Xia Kong, Pin Xu, Wei-Jie Cai, Huai-Gao Wang, Bin-Bin Li, Guo-Liang Huang, Zhi-Wei He, George Chen and Cai-Guo Ye
    Citation: BMC Cancer 2018 18:419
    Content type: Research article Published on:

  25. The expression of DNA fragmentation factor 45 (DFF45) and B-cell lymphoma 2 (BCL2) in glands of the normal human endometrium is related to phases of the menstrual cycle and decreases after menopause, whereas t...

    Authors: Tomasz Banas, Kazimierz Pitynski, Krzysztof Okon and Aleksandra Winiarska
    Citation: BMC Cancer 2018 18:418
    Content type: Research article Published on:

  26. We aimed to assess the prognostic value of CYFRA 21-1 in a series of patients with anal canal squamous cell carcinoma treated by radiation-based therapy.

    Authors: Mathieu Gauthé, Marion Richard-Molard, Eugénie Rigault, Bruno Buecher, Pascale Mariani, Dominique Bellet, Wulfran Cacheux and Astrid Lièvre
    Citation: BMC Cancer 2018 18:417
    Content type: Research article Published on:

  27. Volumetric-modulated arc therapy (VMAT) is a highly sophisticated linear accelerator-based treatment method, and allows dose rate-changing intensity modulation with gantry rotation. We report our clinical expe...

    Authors: Yuri Jeong, Jinhong Jung, Byungchul Cho, Jungwon Kwak, Chiyoung Jeong, Jong Hoon Kim, Jin-hong Park, So Yeon Kim, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Han Chu Lee and Sang Min Yoon
    Citation: BMC Cancer 2018 18:416
    Content type: Research article Published on:

  28. Many novel diagnostic biomarkers have been developed for gastric cancer (GC) recently. We chose two methods with high diagnostic value, the detection of serum microRNAs and metabolomics based on gas chromatogr...

    Authors: Hai-Ning Liu, Hao Wu, Yu-Jen Tseng, Yan-Jie Chen, Dan-Ying Zhang, Lin Zhu, Ling Dong, Xi-Zhong Shen and Tao-Tao Liu
    Citation: BMC Cancer 2018 18:415
    Content type: Research article Published on:

  29. Tumor neoantigens are drivers of cancer immunotherapy response; however, current prediction tools produce many candidates requiring further prioritization. Additional filtration criteria and population-level u...

    Authors: Mary A. Wood, Mayur Paralkar, Mihir P. Paralkar, Austin Nguyen, Adam J. Struck, Kyle Ellrott, Adam Margolin, Abhinav Nellore and Reid F. Thompson
    Citation: BMC Cancer 2018 18:414
    Content type: Technical advance Published on:

  30. It has been highlighted that in the original manuscript [1] Table S3 ‘An example of the predictive computational modeling process. Specific details on an annexure section of the PD-L1 pathway show the step-by-...

    Authors: Kim A. Brogden, Deepak Parashar, Andrea R. Hallier, Terry Braun, Fang Qian, Naiyer A. Rizvi, Aaron D. Bossler, Mohammed M. Milhem, Timothy A. Chan, Taher Abbasi and Shireen Vali
    Citation: BMC Cancer 2018 18:413
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2018 18:225

  31. Mammary cancer is highly prevalent in dogs and cats and results in a poor prognosis due to critically lacking viable treatment options. Recent human and mouse studies have suggested that inhibiting peptidyl ar...

    Authors: Melissa M. Ledet, Robyn Anderson, Rebecca Harman, Aaron Muth, Paul R. Thompson, Scott A. Coonrod and Gerlinde R. Van de Walle
    Citation: BMC Cancer 2018 18:412
    Content type: Research article Published on:

  32. Brucea javanica oil emulsion (BJOE) is traditional Chinese medicine with implicated anti-tumor activity, which has been used for treating lung cancer in China. The aim of this investigation was to evaluate the...

    Authors: Dai Fuhong, Gao Xiang, Li Haiying, Wang Jiangye, Gao Xueming and Chai Wenxiao
    Citation: BMC Cancer 2018 18:411
    Content type: Research article Published on:

  33. Although acute oxaliplatin-induced neuropathy (OXIPN) is frequently regarded to be transient, recent studies have reported prolongation of infusion times, dose reduction and treatment cessation following the f...

    Authors: Endale Gebreegziabher Gebremedhn, Peter John Shortland and David Anthony Mahns
    Citation: BMC Cancer 2018 18:410
    Content type: Research article Published on:

  34. Chronic rhinosinusitis (CRS) increases the risk of developing nasopharyngeal carcinoma (NPC) while nasopharyngeal reflux is known to be one of the major aetiological factors of CRS. Bile acid (BA), the compone...

    Authors: Sang-Nee Tan and Sai-Peng Sim
    Citation: BMC Cancer 2018 18:409
    Content type: Research article Published on:

  35. Improving our understanding of cancer and other complex diseases requires integrating diverse data sets and algorithms. Intertwining in vivo and in vitro data and in silico models are paramount to overcome intrin...

    Authors: Claire Jean-Quartier, Fleur Jeanquartier, Igor Jurisica and Andreas Holzinger
    Citation: BMC Cancer 2018 18:408
    Content type: Debate Published on:

  36. Thirty to 40 % of non-small cell lung cancer (NSCLC) patients developed higher hypertriglyceridemia in the process of treatment with bexarotene. And bioinformatics studies discovered that the expression of slc...

    Authors: Xinghao Ai, Feng Mao, Shengping Shen, Yang Shentu, Jiejun Wang and Shun Lu
    Citation: BMC Cancer 2018 18:407
    Content type: Research article Published on:

  37. Carcinoembryonic antigen (CEA) and carbohydrate antigen (CA)19–9 are used in clinical practice as tumor markers to diagnose or monitor colorectal cancer (CRC) patients, However, their specificities and sensiti...

    Authors: Eiji Shinozaki, Kazuhiro Tanabe, Takashi Akiyoshi, Tomohiro Tsuchida, Yuko Miyazaki, Nozomi Kojima, Masahiro Igarashi, Masashi Ueno, Mitsukuni Suenaga, Nobuyuki Mizunuma, Kensei Yamaguchi, Konosuke Nakayama, Sadayo Iijima and Toshiharu Yamaguchi
    Citation: BMC Cancer 2018 18:406
    Content type: Research article Published on:

  38. Robust and precise molecular prognostic predictors for luminal breast cancer are required. This study aimed to identify key methylation sites in luminal breast cancer, as well as precise molecular tools for pr...

    Authors: Bin Xiao, Lidan Chen, Yongli Ke, Jianfeng Hang, Ling Cao, Rong Zhang, Weiyun Zhang, Yang Liao, Yang Gao, Jianyun Chen, Li Li, Wenbo Hao, Zhaohui Sun and Linhai Li
    Citation: BMC Cancer 2018 18:405
    Content type: Research article Published on:

  39. Melanoma is notoriously resistant to all current modalities of cancer therapies including chemotherapy. In recent years, microRNAs (miRNAs) have emerged as molecular regulators in the development and progressi...

    Authors: Yuxia Li, Jie Zhang, Yajing Liu, Bingyue Zhang, Fubo Zhong, Shubin Wang and Zhengyu Fang
    Citation: BMC Cancer 2018 18:404
    Content type: Research article Published on:

  40. Extramammary Paget disease (EMPD) is a rare malignant dermatosis with poorly defined outcomes. We investigated clinical characteristics of invasive EMPD at different anatomic sites and by subject demographics ...

    Authors: Haijun Yao, Minkai Xie, Shibo Fu, Jianhua Guo, Yubing Peng, Zhikang Cai, Yueqing Jiang, Dachao Zheng and Zhong Wang
    Citation: BMC Cancer 2018 18:403
    Content type: Research article Published on:

  41. Cancer registry data show that survival of colorectal cancer (CRC) in the United Kingdom is poor compared with other European countries and the United States, yet these data sources lack information on patient...

    Authors: Lucía Cea Soriano, Montse Soriano-Gabarró and Luis A. García Rodríguez
    Citation: BMC Cancer 2018 18:402
    Content type: Research article Published on:

  42. Research has revealed that angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) may prevent cancers such as hepatocellular carcinoma (HCC). The comparative chemopreventi...

    Authors: Cheng-Maw Ho, Chih-Hsin Lee, Ming-Chia Lee, Jun-Fu Zhang, Jann-Yuan Wang, Rey-Heng Hu and Po-Huang Lee
    Citation: BMC Cancer 2018 18:401
    Content type: Research article Published on:

  43. The strong invasive and metastatic nature of non-small cell lung cancer (NSCLC) leads to poor prognosis. Collagen triple helix repeat containing 1 (CTHRC1) is involved in cell migration, motility and invasion....

    Authors: Weiling He, Hui Zhang, Yuefeng Wang, Yanbin Zhou, Yifeng Luo, Yongmei Cui, Neng Jiang, Wenting Jiang, Han Wang, Di Xu, Shuhua Li, Zhuo Wang, Yangshan Chen, Yu Sun, Yang Zhang, Hsian-Rong Tseng…
    Citation: BMC Cancer 2018 18:400
    Content type: Research article Published on:

  45. SMARCB1 (INI1) is a tumor-suppressor gene located at 22q11.2. Loss of SMARCB1 protein expression has been reported to be associated with atypical teratoid/rhabdoid tumors and malignant rhabdoid tumors of the kidn...

    Authors: Kazushi Yoshida, Yutaka Fujiwara, Yasushi Goto, Takashi Kohno, Akihiko Yoshida, Koji Tsuta and Yuichiro Ohe
    Citation: BMC Cancer 2018 18:398
    Content type: Case report Published on:

  46. Magnetic resonance (MR)-guided microwave ablation is a well-developed technique for the treatment of tumors, especially hepatic carcinomas. However, there are no detailed reports on the changes in the MR image...

    Authors: Jun Dong, Xiaojing Geng, Yadi Yang, Xiuyu Cai, Pili Hu, Liangping Xia, Bei Zhang and Peihong Wu
    Citation: BMC Cancer 2018 18:397
    Content type: Research article Published on:

  48. Treatment of recurrent nasopharyngeal carcinoma is a challenging clinical problem. We report the case of a 46 year old male showing excellent response and signs of immunostimulation following re-re-irradiation...

    Authors: T. Finazzi, T. Rordorf, K. Ikenberg, G. F. Huber, M. Guckenberger and H. I. Garcia Schueler
    Citation: BMC Cancer 2018 18:395
    Content type: Case report Published on:

  49. Studies on alternative routes to diagnosis stimulated successful policy interventions reducing the number of emergency diagnoses and associated mortality risk. A dearth of evidence on the costs of such interve...

    Authors: Mauro Laudicella, Brendan Walsh, Elaine Burns, Paolo Li Donni and Peter C. Smith
    Citation: BMC Cancer 2018 18:394
    Content type: Research article Published on:

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