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  1. Choriocarcinoma is a rare malignant germ-cell tumour, most commonly found in adult women. It infrequently presents as spontaneous renal haemorrhage (SRH). Genital malformation and SRH secondary to choriocarcin...

    Authors: Yi Li, Gang Chen, Han Chen, Shuang Wen, Chao-yu Xiong, Zi-yi Yang, Yun-xiao Zhu and Nathan Jeffreys
    Citation: BMC Cancer 2018 18:543
    Content type: Case report Published on:

  2. Currently, there are no available targeted therapy options for non-V600 BRAF mutated tumors. The aim of this study was to investigate the effects of RAF and MEK concurrent inhibition on tumor growth, migration...

    Authors: Eszter Molnár, Dominika Rittler, Marcell Baranyi, Michael Grusch, Walter Berger, Balázs Döme, József Tóvári, Clemens Aigner, József Tímár, Tamás Garay and Balázs Hegedűs
    Citation: BMC Cancer 2018 18:542
    Content type: Research article Published on:

  3. An important component of the RAS signalling pathway, the RAS p21 oncogene, is frequently hyperactivated in breast cancer. Its expression in tumor tissue has been linked to poor clinical outcome. This study wa...

    Authors: Malgorzata Banys-Paluchowski, Tanja Fehm, Wolfgang Janni, Bahriye Aktas, Peter A. Fasching, Sabine Kasimir-Bauer, Karin Milde-Langosch, Klaus Pantel, Brigitte Rack, Sabine Riethdorf, Erich-Franz Solomayer, Isabell Witzel and Volkmar Müller
    Citation: BMC Cancer 2018 18:541
    Content type: Research article Published on:

  4. SETDB1 is a histone H3K9 methyltransferase, which plays a significant role in the occurrence and progression of tumors. Previous studies have confirmed that T-lymphom invasion and metastasis gene (Tiam1) is a ...

    Authors: Yuqin Zhang, Jing Huang, Qisheng Li, Keli Chen, Yonghao Liang, Zetao Zhan, Feng Ye, Wen Ni, Longhua Chen and Yi Ding
    Citation: BMC Cancer 2018 18:539
    Content type: Research article Published on:

  5. Neoadjuvant chemoradiotherapy (CRT) followed by total mesorectal excision (TME) has been a standard treatment option for locally advanced rectal cancer with improved local control. However, systemic recurrence...

    Authors: Chang Woo Kim, Byung Mo Kang, Ik Yong Kim, Ji Yeon Kim, Sun Jin Park, Won Cheol Park, Ki Beom Bae, Byung-Noe Bae, Seong Kyu Baek, Seung Hyuk Baik, Gyung Mo Son, Yoon Suk Lee and Suk-Hwan Lee
    Citation: BMC Cancer 2018 18:538
    Content type: Study protocol Published on:

  6. Studies have shown that morbidity and mortality rates due to cancer among recent immigrants are lower than those among the native-born population. The objectives of this study were to describe the incidence of...

    Authors: Jennifer Shuldiner, Ying Liu and Aisha Lofters
    Citation: BMC Cancer 2018 18:537
    Content type: Research article Published on:

  7. Osteosarcoma is the most common primary bone cancer in children and young adults. It is highly aggressive and patients that present with metastasis have a poor prognosis. Angiopoietin-like 4 (ANGPTL4) drives t...

    Authors: T. Zhang, A. Kastrenopoulou, Q. Larrouture, N. A. Athanasou and H. J. Knowles
    Citation: BMC Cancer 2018 18:536
    Content type: Research article Published on:

  8. Recent progress in molecular analysis has advanced the understanding of medulloblastoma (MB) and is anticipated to facilitate management of the disease. MB is composed of 4 molecular subgroups: WNT, SHH, Group...

    Authors: Chanhee Lee, Joongyub Lee, Seung Ah Choi, Seung-Ki Kim, Kyu-Chang Wang, Sung-Hye Park, Se Hoon Kim, Ji Yeoun Lee and Ji Hoon Phi
    Citation: BMC Cancer 2018 18:535
    Content type: Research article Published on:

  9. Malnutrition and weight loss are commonly observed in patients with pancreatic cancer and contribute to poor survival. Pancreatic exocrine insufficiency (PEI), which can be caused by ductal obstruction by a tu...

    Authors: Juan Enrique Domínguez-Muñoz, Laura Nieto-Garcia, Javier López-Díaz, Jose Lariño-Noia, Ihab Abdulkader and Julio Iglesias-Garcia
    Citation: BMC Cancer 2018 18:534
    Content type: Research article Published on:

  10. Neuropilin-1 (NRP-1), a non-tyrosine kinase glycoprotein receptor, is associated with poor prognosis breast cancer, however transcriptomic changes triggered by NRP-1 overexpression and its association with che...

    Authors: Adviti Naik, Aida Al-Yahyaee, Nada Abdullah, Juda-El Sam, Noura Al-Zeheimi, Mahmoud W. Yaish and Sirin A. Adham
    Citation: BMC Cancer 2018 18:533
    Content type: Research article Published on:

  11. Metabolomics is emerging as an important tool for detecting differences between diseased and non-diseased individuals. However, prospective studies are limited.

    Authors: Marcelle M. Dougan, Yuqing Li, Lisa W. Chu, Robert W. Haile, Alice S. Whittemore, Summer S. Han, Steven C. Moore, Joshua N. Sampson, Irene L. Andrulis, Esther M. John and Ann W. Hsing
    Citation: BMC Cancer 2018 18:532
    Content type: Research article Published on:

  12. Positron Emission Tomography/computed tomography (PET/CT) is an imaging technique which has a role in the detection and staging malignancies (both in first diagnosis and follow-up). The finding of an unexpecte...

    Authors: Lucia Moletta, Sergio Bissoli, Alberto Fantin, Nicola Passuello, Michele Valmasoni and Cosimo Sperti
    Citation: BMC Cancer 2018 18:531
    Content type: Research article Published on:

  13. Neuroendocrine carcinoma of the cervix (NECC) is a rare variant of cervical cancer. The prognosis of women with NECC is poor and there is no standardized therapy for this type of malignancy based on controlled...

    Authors: Clemens B. Tempfer, Iris Tischoff, Askin Dogan, Ziad Hilal, Beate Schultheis, Peter Kern and Günther A. Rezniczek
    Citation: BMC Cancer 2018 18:530
    Content type: Research article Published on:

  14. In the last decade many studies showed that the exhaled breath of subjects suffering from several pathological conditions has a peculiar volatile organic compound (VOC) profile. The objective of the present wo...

    Authors: Andrea Princivalle, Lorenzo Monasta, Giovanni Butturini, Claudio Bassi and Luigi Perbellini
    Citation: BMC Cancer 2018 18:529
    Content type: Research article Published on:

  15. Polycythemia vera (PV) is a myeloproliferative neoplasm associated with increased thrombotic and cardiovascular risk, which are key contributors to patient morbidity and mortality. The Veterans Health Administ...

    Authors: Shreekant Parasuraman, Jingbo Yu, Dilan Paranagama, Sulena Shrestha, Li Wang, Onur Baser and Robyn Scherber
    Citation: BMC Cancer 2018 18:528
    Content type: Research article Published on:

  17. The 21-gene Recurrence Score (RS) result predicts outcome and chemotherapy benefit in node-negative and node-positive (N+), estrogen receptor-positive (ER+) patients treated with endocrine therapy. The purpose...

    Authors: Frédérique Penault-Llorca, Thomas Filleron, Bernard Asselain, Frederick L. Baehner, Pierre Fumoleau, Magali Lacroix-Triki, Joseph M. Anderson, Carl Yoshizawa, Diana B. Cherbavaz, Steven Shak, Lise Roca, Christine Sagan, Jérôme Lemonnier, Anne-Laure Martin and Henri Roché
    Citation: BMC Cancer 2018 18:526
    Content type: Research article Published on:

  18. Several studies have reported the role of CYP2A6 genetic polymorphisms in smoking and lung cancer risk with some contradictory results in different populations. The purpose of the current study is to assess th...

    Authors: Nada Ezzeldin, Dalia El-Lebedy, Amira Darwish, Ahmed El Bastawisy, Shereen Hamdy Abd Elaziz, Mirhane Mohamed Hassan and Amal Saad-Hussein
    Citation: BMC Cancer 2018 18:525
    Content type: Research article Published on:

  19. The phosphatase chronophin (CIN/PDXP) has been shown to be an important regulator of glioma cell migration and invasion. It has two known substrates: p-Ser3-cofilin, the phosphorylated form of the actin bindin...

    Authors: Markus Schulze, Maria Hutterer, Anja Sabo, Sabine Hoja, Julia Lorenz, Tanja Rothhammer-Hampl, Christel Herold-Mende, Lucia Floßbach, Camelia Monoranu and Markus J. Riemenschneider
    Citation: BMC Cancer 2018 18:524
    Content type: Research article Published on:

  22. Standardized treatment in pediatric patients with Hodgkin’s lymphoma (HL) follows risk stratification by tumor stage, erythrocyte sedimentation rate and tumor bulk. We aimed to identify quantitative parameters...

    Authors: Julian M. M. Rogasch, Patrick Hundsdoerfer, Frank Hofheinz, Florian Wedel, Imke Schatka, Holger Amthauer and Christian Furth
    Citation: BMC Cancer 2018 18:521
    Content type: Research article Published on:

  23. Melanoma is a rare, deadly disease without effective treatment options in China. Vemurafenib is a selective inhibitor of oncogenic BRAFV600 kinase approved in more than 90 countries, based on results obtained pri...

    Authors: Lu Si, Xiaoshi Zhang, Zhen Xu, Qiudi Jiang, Lilian Bu, Xuan Wang, Lili Mao, Weijiang Zhang, Nicole Richie and Jun Guo
    Citation: BMC Cancer 2018 18:520
    Content type: Research article Published on:

  26. Colorectal cancer (CRC) is a leading cause of cancer-related death. The biologic response of CRC to standard of care adjuvant therapies such as chemotherapy and radiation are poorly understood. MicroRNAs (miRs...

    Authors: Rebecca Ruhl, Shushan Rana, Katherine Kelley, Cristina Espinosa-Diez, Clayton Hudson, Christian Lanciault, Charles R. Thomas Jr, V. Liana Tsikitis and Sudarshan Anand
    Citation: BMC Cancer 2018 18:517
    Content type: Research article Published on:

  27. 6-mercaptopurine (6-MP) contributes substantially to remarkable improvement in the survival of childhood acute lymphoblastic leukemia (ALL) patients. However, 6-MP also has dose-limiting toxicities, particular...

    Authors: Hong Zhou, Lei Li, Peng Yang, Lin Yang, Jin E. Zheng, Ying Zhou and Yong Han
    Citation: BMC Cancer 2018 18:516
    Content type: Research article Published on:

  28. Gastric cancer is common in developing regions, and we hope to find out an economical but practical prognostic indicator. It was reported that pre-treatment peripheral neutrophil-to-lymphocyte ratio (NLR) and ...

    Authors: Zhenhua Huang, Yantan Liu, Chen Yang, Xiaoyin Li, Changqie Pan, Jinjun Rao, Nailin Li, Wangjun Liao and Li Lin
    Citation: BMC Cancer 2018 18:515
    Content type: Research article Published on:

  30. Short telomeres have been associated with increased risk of many cancers, particularly cancers of the gastrointestinal tract including esophagus and stomach. However, the association between telomere length (T...

    Authors: Sheetal Hardikar, Andrea N. Burnett-Hartman, Amanda I. Phipps, Melissa P. Upton, Lee-Ching Zhu and Polly A. Newcomb
    Citation: BMC Cancer 2018 18:513
    Content type: Research article Published on:

  32. Hepatocellular carcinoma (HCC) often arises in the setting of chronic inflammation with multiple inhibitory immune signals. V-domain Ig suppressor of T cell activation (VISTA) is identified as a novel negative...

    Authors: Ming Zhang, Hua-Jin Pang, Wei Zhao, Yu-Fa Li, Li-Xu Yan, Zhong-Yi Dong and Xiao-Feng He
    Citation: BMC Cancer 2018 18:511
    Content type: Research article Published on:

  33. Nausea/vomiting (N/V) not related to anti-cancer treatment is common in patients with advanced cancer. The standard approach to management is to define a dominant cause, and treat with an antiemetic selected t...

    Authors: Janet Hardy, Helen Skerman, Paul Glare, Jennifer Philip, Peter Hudson, Geoffrey Mitchell, Peter Martin, Odette Spruyt, David Currow and Patsy Yates
    Citation: BMC Cancer 2018 18:510
    Content type: Research article Published on:

  34. The fecal immunochemical test (FIT) is easier to use and more sensitive than the guaiac fecal occult blood test, but it is unclear how to optimize FIT performance. We compared the sensitivity and specificity f...

    Authors: Elizabeth G. Liles, Nancy Perrin, Ana G. Rosales, David H. Smith, Adrianne C. Feldstein, David M. Mosen and Theodore R. Levin
    Citation: BMC Cancer 2018 18:509
    Content type: Research article Published on:

  35. Gastric cancer is the eighth most common cancer in Taiwan, with a 40% 5-year survival rate. Approximately 40% of patients are refractory to chemotherapy. Currently, the anti-HER2 therapy is the only clinically...

    Authors: Yung-Yu Hsieh, Shui-Yi Tung, Hung-Yu Pan, Chih-Wei Yen, Huang-Wei Xu, Yi-Fang Deng, Ying-Jhen Lin, Wan-Ting Hsu, Cheng-Shyong Wu and Chin Li
    Citation: BMC Cancer 2018 18:508
    Content type: Research article Published on:

  36. Tamoxifen is a frontline therapy for estrogen receptor (ER)-positive breast cancer in premenopausal women. However, many patients develop resistance to tamoxifen, and the mechanism underlying tamoxifen resista...

    Authors: Wei Li, Ling Xu, Xiaofang Che, Haizhou Li, Ye Zhang, Na Song, Ti Wen, Kezuo Hou, Yi Yang, Lu Zhou, Xing Xin, Lu Xu, Xue Zeng, Sha Shi, Yunpeng Liu, Xiujuan Qu…
    Citation: BMC Cancer 2018 18:507
    Content type: Research article Published on:

  37. Dickkopf-1 (DKK1) is a Wnt/ß-catenin pathway antagonist related to gastric cancer (GC) carcinogenesis. However, the prognostic role of combined DKK1 and ß-catenin expression in advanced GC (AGC) is not clear.

    Authors: Soon Auck Hong, Su Hyun Yoo, Han Hong Lee, Der Sheng Sun, Hye Sung Won, Okran Kim and Yoon Ho Ko
    Citation: BMC Cancer 2018 18:506
    Content type: Research article Published on:

  38. Glomus tumor is a rare benign neoplasm, which most frequently occurs in the subungual regions of digits. Tumor rupture and infection occurred in one patient with a glomus tumor have never been reported.

    Authors: Hui Lu, Li Feng Chen and Qiang Chen
    Citation: BMC Cancer 2018 18:505
    Content type: Case report Published on:

  39. Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate that carries a cytotoxic drug (DM1) to HER2-positive cancer. The target of T-DM1 (HER2) is present also on cancer-derived exosomes. We hypothesized t...

    Authors: Mark Barok, Maija Puhka, Gyorgy Vereb, Janos Szollosi, Jorma Isola and Heikki Joensuu
    Citation: BMC Cancer 2018 18:504
    Content type: Research article Published on:

  40. Ewing’s sarcoma is a primary malignant tumor of bone occurring mostly in childhood. Few effective reconstruction techniques are available after wide resection of Ewing’s sarcoma at the distal end of the tibia....

    Authors: Naoki Mizoshiri, Toshiharu Shirai, Ryu Terauchi, Shinji Tsuchida, Yuki Mori, Yusei Katsuyama, Daichi Hayashi, Yoshinobu Oka and Toshikazu Kubo
    Citation: BMC Cancer 2018 18:503
    Content type: Case report Published on:

  41. Laterally spreading tumours (LSTs) are superficial neoplasms that usually extend laterally along the intra-luminal wall of the gastrointestinal tract. Recently, the incidence of LSTs in the colorectal mucosa h...

    Authors: Samiullah Khan, Lan-ping Zhu, Yujie Zhang, Xin Chen and Bang-mao Wang
    Citation: BMC Cancer 2018 18:502
    Content type: Case report Published on:

  42. A computer-assisted diagnostic system for analyzing bone scans (BONENAVI) calculates the automated bone scan index (aBSI). Here we evaluated the aBSI as a prognostic imaging biomarker for men with metastatic c...

    Authors: Koichi Uemura, Yasuhide Miyoshi, Takashi Kawahara, Jikuya Ryosuke, Daisuke Yamashita, Shuko Yoneyama, Yumiko Yokomizo, Kazuki Kobayashi, Takeshi Kishida, Masahiro Yao and Hiroji Uemura
    Citation: BMC Cancer 2018 18:501
    Content type: Research article Published on:

  44. Following the recommendation of lung cancer screening in the US, screening committees in several European countries are reviewing the evidence for implementing national programmes. However, inadequate particip...

    Authors: Samantha L. Quaife, Charlotte Vrinten, Mamta Ruparel, Samuel M. Janes, Rebecca J. Beeken, Jo Waller and Andy McEwen
    Citation: BMC Cancer 2018 18:497
    Content type: Research article Published on:

  45. The transcription factor PAX6 is expressed in various cancers. In anaplastic astrocytic glioma, PAX6 expression is inversely related to tumor grade, resulting in low PAX6 expression in Glioblastoma, the highes...

    Authors: Beate Hegge, Eva Sjøttem and Ingvild Mikkola
    Citation: BMC Cancer 2018 18:496
    Content type: Research article Published on:

  46. The E-selectin ligands expressed by cancer cells mediate adhesion of circulating cancer cells to endothelial cells, as well as within tissue microenvironments important for tumor progression and metastasis. Th...

    Authors: Mylène A. Carrascal, Catarina Talina, Paula Borralho, A. Gonçalo Mineiro, Ana Raquel Henriques, Cláudia Pen, Manuela Martins, Sofia Braga, Robert Sackstein and Paula A. Videira
    Citation: BMC Cancer 2018 18:495
    Content type: Technical advance Published on:

  47. Somatic amplifications of the LYL1 gene are relatively common occurrences in patients who develop uterine corpus endometrial carcinoma (UCEC) as opposed to other cancers. This study was undertaken to determine wh...

    Authors: Se Ik Kim, Ji Won Lee, Nara Lee, Maria Lee, Hee Seung Kim, Hyun Hoon Chung, Jae-Weon Kim, Noh Hyun Park, Yong-Sang Song and Jeong-Sun Seo
    Citation: BMC Cancer 2018 18:494
    Content type: Research article Published on:

  48. There is growing evidence that the transcription factor nuclear factor E2-related factor 2 (Nrf2) is the major participant in regulating antioxidants and pathways for detoxifying reactive oxygen species (ROS),...

    Authors: Akinori Nukui, Takahiro Narimatsu, Tsunehito Kambara, Hideyuki Abe, Setsu Sakamoto, Ken-Ichiro Yoshida and Takao Kamai
    Citation: BMC Cancer 2018 18:493
    Content type: Research article Published on:

  49. Stage is a key predictor of cancer survival. Complete cancer staging is vital for understanding outcomes at population level and monitoring the efficacy of early diagnosis initiatives. Cancer registries usuall...

    Authors: Chiara Di Girolamo, Sarah Walters, Sara Benitez Majano, Bernard Rachet, Michel P. Coleman, Edmund Njeru Njagi and Melanie Morris
    Citation: BMC Cancer 2018 18:492
    Content type: Research article Published on:

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