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  1. Previous studies showed sanguinarine induced apoptosis in CRC cells but did not define the underlying mechanisms. The purpose of this work was to determine the in vivo and in vitro effects of sanguinarine on C...

    Authors: Xianling Gong, Zhihong Chen, Qinrui Han, Chunhui Chen, Linlin Jing, Yawei Liu, Liang Zhao, Xueqing Yao and Xuegang Sun
    Citation: BMC Cancer 2018 18:578
    Content type: Research article Published on:

  2. The right drug to the right patient at the right time is one of the ideals of Individualized Medicine (IM) and remains one of the most compelling promises of the post-genomic age. The addition of genomic infor...

    Authors: Michael T. Zimmermann, Terry M. Therneau and Jean-Pierre A. Kocher
    Citation: BMC Cancer 2018 18:577
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2018 18:743

  3. The objectives of this study were to build a normal tissue complication probability (NTCP) model of radiation-induced hypothyroidism (RHT) for nasopharyngeal carcinoma (NPC) patients and to compare it with oth...

    Authors: Ren Luo, Vincent W. C. Wu, Binghui He, Xiaoying Gao, Zhenxi Xu, Dandan Wang, Zhining Yang, Mei Li and Zhixiong Lin
    Citation: BMC Cancer 2018 18:575
    Content type: Research article Published on:

  4. Immune surveillance acts as a defense mechanism in cancer, and its disruption is involved in cancer progression. DNA methylation reflects the phenotypic identity of cells and recent data suggested that DNA met...

    Authors: Surabhi Parashar, David Cheishvili, Niaz Mahmood, Ani Arakelian, Imrana Tanvir, Haseeb Ahmed Khan, Richard Kremer, Catalin Mihalcioiu, Moshe Szyf and Shafaat A. Rabbani
    Citation: BMC Cancer 2018 18:574
    Content type: Research article Published on:

  5. Standard treatment for unresectable esophageal squamous cell carcinoma (ESCC) without distant metastasis is definitive chemoradiotherapy (dCRT), in which the incidence of esophageal fistula (EF) is reported to...

    Authors: Takeshi Kawakami, Takahiro Tsushima, Katsuhiro Omae, Hirofumi Ogawa, Hiromichi Shirasu, Yosuke Kito, Yukio Yoshida, Satoshi Hamauchi, Akiko Todaka, Nozomu Machida, Tomoya Yokota, Kentaro Yamazaki, Akira Fukutomi, Yusuke Onozawa and Hirofumi Yasui
    Citation: BMC Cancer 2018 18:573
    Content type: Research article Published on:

  6. Hepatocellular carcinoma (HCC) is a frequent type of primary liver cancer, and its prevalence is increasing worldwide. Indeed, the underlying molecular mechanism is not well understood. Previous studies have s...

    Authors: Amit Kumar Ram, Biju Pottakat and Balasubramaniyan Vairappan
    Citation: BMC Cancer 2018 18:572
    Content type: Research article Published on:

  7. Efforts have been made to classify Hepatocellular Carcinoma (HCC) at surgically curable stages because molecular classification, which is prognostically informative, can accurately identify patients in need of...

    Authors: Sung-Min Ahn, Farhan Haq, Inkeun Park, Jean-Charles Nault, Jessica Zucman-Rossi and Eunsil Yu
    Citation: BMC Cancer 2018 18:571
    Content type: Research article Published on:

  8. A-disintegrin and metalloproteinases (ADAMs) are members of a family of multidomain transmembrane and secreted proteins. Specific ADAMs are upregulated in human cancers and correlated with tumor progression an...

    Authors: Xiaodong Jiao, Wenlong Yu, Jianxin Qian, Ying Chen, Peilian Wei, Wenzheng Fang and Guanzhen Yu
    Citation: BMC Cancer 2018 18:570
    Content type: Research article Published on:

  9. The smoothened (SMO) receptor is an essential component of the Sonic hedgehog (SHH) signalling, which is associated with the development of skin basal cell carcinoma (BCC). SMO inhibitors are indicated for BCC...

    Authors: Antoine Buetti-Dinh, Rebecca Jensen and Ran Friedman
    Citation: BMC Cancer 2018 18:569
    Content type: Research article Published on:

  10. Inter-patient variability in response to opioids is well known but a comprehensive definition of its pathophysiological mechanism is still lacking and, more importantly, no studies have focused on children. Th...

    Authors: Ersilia Lucenteforte, Laura Vagnoli, Alessandra Pugi, Giada Crescioli, Niccolò Lombardi, Roberto Bonaiuti, Maurizio Aricò, Sabrina Giglio, Andrea Messeri, Alessandro Mugelli, Alfredo Vannacci and Valentina Maggini
    Citation: BMC Cancer 2018 18:568
    Content type: Research article Published on:

  11. Management of squamous cell carcinoma of the anus (SCCA) is becoming more relevant, as its incidence increases. The purpose of this study was to investigate possible differences in patient population and care ...

    Authors: Victor E. Pricolo, Matteo Bonvini and Carlo F. Abelli
    Citation: BMC Cancer 2018 18:567
    Content type: Research article Published on:

  12. Prospective trials have demonstrated the advantage of dose-escalated radiotherapy for the biochemical and clinical control of intermediate risk prostate cancer. Dose escalation improves outcomes but increases ...

    Authors: David Pasquier, Emilie Bogart, François Bonodeau, Thomas Lacornerie, Eric Lartigau and Igor Latorzeff
    Citation: BMC Cancer 2018 18:566
    Content type: Study protocol Published on:

  13. Cervical cancer is a global leading cause of morbidity and mortality, attributable to the death of approximately 266,000 women every year. Majority (87%) of cervical cancer deaths occur in developing countries...

    Authors: Mabula M. Mabelele, John Materu, Faraja D. Ng’ida and Michael J. Mahande
    Citation: BMC Cancer 2018 18:565
    Content type: Research article Published on:

  14. Ceramide synthesis and metabolism is a promising target in cancer drug development. γ-tocotrienol (GT3), a member of the vitamin E family, orchestrates multiple effects that ensure the induction of apoptosis i...

    Authors: Victoria E. Palau, Kanishka Chakraborty, Daniel Wann, Janet Lightner, Keely Hilton, Marianne Brannon, William Stone and Koyamangalath Krishnan
    Citation: BMC Cancer 2018 18:564
    Content type: Research article Published on:

  15. The relatively low incidence of duodenal gastrointestinal stromal tumors (GISTs) and the unique anatomy make the surgical management and outcomes of this kind of tumor still under debate. Thus, this study aime...

    Authors: Zhen Liu, Gaozan Zheng, Jinqiang Liu, Shushang Liu, Guanghui Xu, Qiao Wang, Man Guo, Xiao Lian, Hongwei Zhang and Fan Feng
    Citation: BMC Cancer 2018 18:563
    Content type: Research article Published on:

  16. A low cost and accurate method for detecting high-risk (HR) human papillomavirus (HPV) is important to permit HPV testing for cervical cancer prevention. We used a commercially available HPV method (H13, Hybri...

    Authors: Hong Lou, Eduardo Gharzouzi, Sarita Polo Guerra, Joël Fokom Domgue, Julie Sawitzke, Guillermo Villagran, Lisa Garland, Joseph F. Boland, Sarah Wagner, Héctor Rosas, Jami Troxler, Heidi McMillen, Bailey Kessing, Enrique Alvirez, Miriam Castillo, Hesler Morales…
    Citation: BMC Cancer 2018 18:562
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2020 20:164

  17. Renal epithelioid angiomyolipomas (EAML) are rare tumors with aggressive behavior. EAML can be sporadic or develop within the tuberous sclerosis complex syndrome, where mutations of TSC1 or TSC2 genes (critical n...

    Authors: Marta Espinosa, Juan Maria Roldán-Romero, Ignacio Duran, Enrique de Álava, María Apellaniz-Ruiz, Alberto Cascón, Carmen Garrigos, Mercedes Robledo and Cristina Rodriguez-Antona
    Citation: BMC Cancer 2018 18:561
    Content type: Case report Published on:

  18. Neuroblastoma (NB) is a devastating disease. Despite recent advances in the treatment of NB, about 60% of high-risk NB will have relapse and therefore long-term event free survival is very minimal. We have rep...

    Authors: Selvi Kunnimalaiyaan, Victoriana K. Schwartz, Iris Alao Jackson, T. Clark Gamblin and Muthusamy Kunnimalaiyaan
    Citation: BMC Cancer 2018 18:560
    Content type: Research article Published on:

  19. Glutamate oxaloacetate transaminase 1 (GOT1) regulates cellular metabolism through coordinating the utilization of carbohydrates and amino acids to meet nutrient requirements. KRAS mutated cancer cells were re...

    Authors: Xiaoshan Zhou, Sophie Curbo, Fuqiang Li, Shuba Krishnan and Anna Karlsson
    Citation: BMC Cancer 2018 18:559
    Content type: Research article Published on:

  20. The consensus is that a minimum of 12 lymph nodes should be analyzed at colectomy for colon cancer. However, right colon cancer and left colon cancer have different characteristics, and this threshold value fo...

    Authors: Lin Yang, Zhenchong Xiong, Qiankun Xie, Wenzhuo He, Shousheng Liu, Pengfei Kong, Chang Jiang, Guifang Guo and Liangping Xia
    Citation: BMC Cancer 2018 18:558
    Content type: Research article Published on:

  21. All women are potentially at risk of developing cervical cancer at some point in their life, yet it is avoidable cause of death among women in Sub- Saharan Africa with a world incidence of 530,000 every year. ...

    Authors: Hillary Mabeya, Sonia Menon, Steven Weyers, Violet Naanyu, Emily Mwaliko, Elijah Kirop, Omenge Orango, Heleen Vermandere and Davy Vanden Broeck
    Citation: BMC Cancer 2018 18:557
    Content type: Research article Published on:

  22. Tumors develop multiple mechanisms of immune evasion as they progress, with some cancer types being inherently better at ‘hiding’ than others. With an increased understanding of tumor immune surveillance, immu...

    Authors: Joshua P. Bates, Roshanak Derakhshandeh, Laundette Jones and Tonya J. Webb
    Citation: BMC Cancer 2018 18:556
    Content type: Debate Published on:

  23. Single Nucleotide Polymorphisms (SNPs) can influence patient outcome such as drug response and toxicity after drug intervention. The purpose of this study is to develop a systematic pathway approach to accurat...

    Authors: Vachiranee Limviphuvadh, Chee Seng Tan, Fumikazu Konishi, Piroon Jenjaroenpun, Joy Shengnan Xiang, Yuliya Kremenska, Yar Soe Mu, Nicholas Syn, Soo Chin Lee, Ross A. Soo, Frank Eisenhaber, Sebastian Maurer-Stroh and Wei Peng Yong
    Citation: BMC Cancer 2018 18:555
    Content type: Research article Published on:

  24. High resolution anoscopy (HRA) examination is regarded as the best method for the management of anal high grade squamous intraepithelial lesions to prevent anal squamous carcinoma. However, little is known abo...

    Authors: Anke De-Masi, Esther Davis, Tamzin Cuming, Noreen Chindawi, Francesca Pesola, Carmelina Cappello, Susan Chambers, Julie Bowring, Adam N. Rosenthal, Peter Sasieni and Mayura Nathan
    Citation: BMC Cancer 2018 18:554
    Content type: Research article Published on:

  25. Vascular endothelial growth factor (VEGF) isoforms, particularly the diffusible VEGF-121, could play a major role in the response of recurrent glioblastoma (GB) to anti-angiogenetic treatment with bevacizumab....

    Authors: Maurizio Martini, Ivana de Pascalis, Quintino Giorgio D’Alessandris, Vincenzo Fiorentino, Francesco Pierconti, Hany El-Sayed Marei, Lucia Ricci-Vitiani, Roberto Pallini and Luigi Maria Larocca
    Citation: BMC Cancer 2018 18:553
    Content type: Research article Published on:

  26. It is frequently asked whether chemotherapy can still play a role in metastatic melanoma considering the effectiveness of the available drugs today, including antiCTLA4/antiPD1 immunotherapy and antiBRAF/antiM...

    Authors: Michele Guida, Stefania Tommasi, Sabino Strippoli, Maria Iole Natalicchio, Simona De Summa, Rosamaria Pinto, Antonio Cramarossa, Anna Albano, Salvatore Pisconti, Michele Aieta, Ruggiero Ridolfi, Amalia Azzariti, Gabriella Guida, Vito Lorusso and Giusepe Colucci
    Citation: BMC Cancer 2018 18:552
    Content type: Research article Published on:

  27. Multiple myeloma (MM), like other cancers, is caused by the accumulation of genetic abnormalities. Heterogeneity exists in the patients’ response to treatments, for example, bortezomib. This urges efforts to i...

    Authors: Xinyan Zhang, Bingzong Li, Huiying Han, Sha Song, Hongxia Xu, Yating Hong, Nengjun Yi and Wenzhuo Zhuang
    Citation: BMC Cancer 2018 18:551
    Content type: Research article Published on:

  28. Liver cancer is the second leading cause of cancer-related deaths and characterized by heterogeneity and drug resistance. Patient-derived xenograft (PDX) models have been widely used in cancer research because...

    Authors: Sheng He, Bo Hu, Chao Li, Ping Lin, Wei-Guo Tang, Yun-Fan Sun, Fang-You-Min Feng, Wei Guo, Jia Li, Yang Xu, Qian-Lan Yao, Xin Zhang, Shuang-Jian Qiu, Jian Zhou, Jia Fan, Yi-Xue Li…
    Citation: BMC Cancer 2018 18:550
    Content type: Database Published on:

  29. While data from several studies over the last decade has demonstrated that introduction of immunologic checkpoint blockage therapy with anti-CTLA-4/PD-1 drugs leads to improved survival in metastatic melanoma ...

    Authors: Marin A. McDonald, Parag Sanghvi, Julie Bykowski and Gregory A. Daniels
    Citation: BMC Cancer 2018 18:549
    Content type: Case report Published on:

  30. Pathologic response to neoadjuvant chemotherapy (neoCTX) is a prognostic factor in many cancer types, and early prediction would help to modify treatment. In patients with gastric and esophagogastric junction ...

    Authors: Paul M. Schneider, Dilmurodjon Eshmuminov, Tamara Rordorf, Diana Vetter, Patrick Veit-Haibach, Achim Weber, Peter Bauerfeind, Panagiotis Samaras and Kuno Lehmann
    Citation: BMC Cancer 2018 18:548
    Content type: Research article Published on:

  31. S-1 plus oxaliplatin(SOX) has been demonstrated to be effective and well tolerated for patients with metastatic gastric cancer. We conducted this phase II study to evaluate the feasibility of SOX as adjuvant c...

    Authors: Guoxiu Wang, Jiuda Zhao, Yan Song, Wen Zhang, Yongkun Sun, Aiping Zhou, Jing Huang, Feng Du and Lin Yang
    Citation: BMC Cancer 2018 18:547
    Content type: Research article Published on:

  33. Prostate-specific antigen (PSA) screening more frequently detects early stage prostate cancer (PC). However, adverse pathologic features (APFs) after radical prostatectomy (RP) in low-risk PC occur. Previous r...

    Authors: Jae Won Park, Dong Hoon Koh, Won Sik Jang, Kang Su Cho, Won Sik Ham, Koon Ho Rha, Sung Joon Hong and Young Deuk Choi
    Citation: BMC Cancer 2018 18:545
    Content type: Research article Published on:

  35. Choriocarcinoma is a rare malignant germ-cell tumour, most commonly found in adult women. It infrequently presents as spontaneous renal haemorrhage (SRH). Genital malformation and SRH secondary to choriocarcin...

    Authors: Yi Li, Gang Chen, Han Chen, Shuang Wen, Chao-yu Xiong, Zi-yi Yang, Yun-xiao Zhu and Nathan Jeffreys
    Citation: BMC Cancer 2018 18:543
    Content type: Case report Published on:

  36. Currently, there are no available targeted therapy options for non-V600 BRAF mutated tumors. The aim of this study was to investigate the effects of RAF and MEK concurrent inhibition on tumor growth, migration...

    Authors: Eszter Molnár, Dominika Rittler, Marcell Baranyi, Michael Grusch, Walter Berger, Balázs Döme, József Tóvári, Clemens Aigner, József Tímár, Tamás Garay and Balázs Hegedűs
    Citation: BMC Cancer 2018 18:542
    Content type: Research article Published on:

  37. An important component of the RAS signalling pathway, the RAS p21 oncogene, is frequently hyperactivated in breast cancer. Its expression in tumor tissue has been linked to poor clinical outcome. This study wa...

    Authors: Malgorzata Banys-Paluchowski, Tanja Fehm, Wolfgang Janni, Bahriye Aktas, Peter A. Fasching, Sabine Kasimir-Bauer, Karin Milde-Langosch, Klaus Pantel, Brigitte Rack, Sabine Riethdorf, Erich-Franz Solomayer, Isabell Witzel and Volkmar Müller
    Citation: BMC Cancer 2018 18:541
    Content type: Research article Published on:

  39. SETDB1 is a histone H3K9 methyltransferase, which plays a significant role in the occurrence and progression of tumors. Previous studies have confirmed that T-lymphom invasion and metastasis gene (Tiam1) is a ...

    Authors: Yuqin Zhang, Jing Huang, Qisheng Li, Keli Chen, Yonghao Liang, Zetao Zhan, Feng Ye, Wen Ni, Longhua Chen and Yi Ding
    Citation: BMC Cancer 2018 18:539
    Content type: Research article Published on:

  40. Neoadjuvant chemoradiotherapy (CRT) followed by total mesorectal excision (TME) has been a standard treatment option for locally advanced rectal cancer with improved local control. However, systemic recurrence...

    Authors: Chang Woo Kim, Byung Mo Kang, Ik Yong Kim, Ji Yeon Kim, Sun Jin Park, Won Cheol Park, Ki Beom Bae, Byung-Noe Bae, Seong Kyu Baek, Seung Hyuk Baik, Gyung Mo Son, Yoon Suk Lee and Suk-Hwan Lee
    Citation: BMC Cancer 2018 18:538
    Content type: Study protocol Published on:

  41. Studies have shown that morbidity and mortality rates due to cancer among recent immigrants are lower than those among the native-born population. The objectives of this study were to describe the incidence of...

    Authors: Jennifer Shuldiner, Ying Liu and Aisha Lofters
    Citation: BMC Cancer 2018 18:537
    Content type: Research article Published on:

  42. Osteosarcoma is the most common primary bone cancer in children and young adults. It is highly aggressive and patients that present with metastasis have a poor prognosis. Angiopoietin-like 4 (ANGPTL4) drives t...

    Authors: T. Zhang, A. Kastrenopoulou, Q. Larrouture, N. A. Athanasou and H. J. Knowles
    Citation: BMC Cancer 2018 18:536
    Content type: Research article Published on:

  43. Recent progress in molecular analysis has advanced the understanding of medulloblastoma (MB) and is anticipated to facilitate management of the disease. MB is composed of 4 molecular subgroups: WNT, SHH, Group...

    Authors: Chanhee Lee, Joongyub Lee, Seung Ah Choi, Seung-Ki Kim, Kyu-Chang Wang, Sung-Hye Park, Se Hoon Kim, Ji Yeoun Lee and Ji Hoon Phi
    Citation: BMC Cancer 2018 18:535
    Content type: Research article Published on:

  44. Malnutrition and weight loss are commonly observed in patients with pancreatic cancer and contribute to poor survival. Pancreatic exocrine insufficiency (PEI), which can be caused by ductal obstruction by a tu...

    Authors: Juan Enrique Domínguez-Muñoz, Laura Nieto-Garcia, Javier López-Díaz, Jose Lariño-Noia, Ihab Abdulkader and Julio Iglesias-Garcia
    Citation: BMC Cancer 2018 18:534
    Content type: Research article Published on:

  45. Neuropilin-1 (NRP-1), a non-tyrosine kinase glycoprotein receptor, is associated with poor prognosis breast cancer, however transcriptomic changes triggered by NRP-1 overexpression and its association with che...

    Authors: Adviti Naik, Aida Al-Yahyaee, Nada Abdullah, Juda-El Sam, Noura Al-Zeheimi, Mahmoud W. Yaish and Sirin A. Adham
    Citation: BMC Cancer 2018 18:533
    Content type: Research article Published on:

  46. Metabolomics is emerging as an important tool for detecting differences between diseased and non-diseased individuals. However, prospective studies are limited.

    Authors: Marcelle M. Dougan, Yuqing Li, Lisa W. Chu, Robert W. Haile, Alice S. Whittemore, Summer S. Han, Steven C. Moore, Joshua N. Sampson, Irene L. Andrulis, Esther M. John and Ann W. Hsing
    Citation: BMC Cancer 2018 18:532
    Content type: Research article Published on:

  47. Positron Emission Tomography/computed tomography (PET/CT) is an imaging technique which has a role in the detection and staging malignancies (both in first diagnosis and follow-up). The finding of an unexpecte...

    Authors: Lucia Moletta, Sergio Bissoli, Alberto Fantin, Nicola Passuello, Michele Valmasoni and Cosimo Sperti
    Citation: BMC Cancer 2018 18:531
    Content type: Research article Published on:

  48. Neuroendocrine carcinoma of the cervix (NECC) is a rare variant of cervical cancer. The prognosis of women with NECC is poor and there is no standardized therapy for this type of malignancy based on controlled...

    Authors: Clemens B. Tempfer, Iris Tischoff, Askin Dogan, Ziad Hilal, Beate Schultheis, Peter Kern and Günther A. Rezniczek
    Citation: BMC Cancer 2018 18:530
    Content type: Research article Published on:

  49. Polycythemia vera (PV) is a myeloproliferative neoplasm associated with increased thrombotic and cardiovascular risk, which are key contributors to patient morbidity and mortality. The Veterans Health Administ...

    Authors: Shreekant Parasuraman, Jingbo Yu, Dilan Paranagama, Sulena Shrestha, Li Wang, Onur Baser and Robyn Scherber
    Citation: BMC Cancer 2018 18:528
    Content type: Research article Published on:

  50. The 21-gene Recurrence Score (RS) result predicts outcome and chemotherapy benefit in node-negative and node-positive (N+), estrogen receptor-positive (ER+) patients treated with endocrine therapy. The purpose...

    Authors: Frédérique Penault-Llorca, Thomas Filleron, Bernard Asselain, Frederick L. Baehner, Pierre Fumoleau, Magali Lacroix-Triki, Joseph M. Anderson, Carl Yoshizawa, Diana B. Cherbavaz, Steven Shak, Lise Roca, Christine Sagan, Jérôme Lemonnier, Anne-Laure Martin and Henri Roché
    Citation: BMC Cancer 2018 18:526
    Content type: Research article Published on:

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