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  1. Several trials evaluated the role of ovarian function suppression for the adjuvant treatment of premenopausal patients with hormone receptor-positive early breast cancer. Based on the results of the SOFT and T...

    Authors: Giacomo Pelizzari, Grazia Arpino, Laura Biganzoli, Saverio Cinieri, Michelino De Laurentiis, Lucia Del Mastro, Angelo Di Leo, Stefania Gori, Valentina Guarneri, Paolo Marchetti and Fabio Puglisi
    Citation: BMC Cancer 2018 18:932
    Content type: Research article Published on:

  2. Improved risk stratification, more effective therapy and better supportive care have resulted in survival rates after childhood cancer of around 80% in developed countries. Treatment however can be harsh, and ...

    Authors: Anne-Lotte L. F. van der Kooi, Eva Clemens, Linda Broer, Oliver Zolk, Julianne Byrne, Helen Campbell, Marleen van den Berg, Claire Berger, Gabriele Calaminus, Uta Dirksen, Jeanette Falck Winther, Sophie D FossÃ¥, Desiree Grabow, Riccardo Haupt, Melanie Kaiser, Tomas Kepak…
    Citation: BMC Cancer 2018 18:930
    Content type: Study protocol Published on:

  3. Chimeric antigen receptor T (CAR T) cells immunotherapy is rapidly developed in treating cancers, especially relapsed or refractory B-cell malignancies.

    Authors: Hui Zhou, Yuling Luo, Sha Zhu, Xi Wang, Yunuo Zhao, Xuejin Ou, Tao Zhang and Xuelei Ma
    Citation: BMC Cancer 2018 18:929
    Content type: Research article Published on:

  4. Cancer stem cells (CSC) are characterized by deregulated self-renewal, tumorigenicity, metastatic potential, aberrant stemness signaling pathways, resistance to conventional therapy, and the ability to give ri...

    Authors: Gabriele Davide Bigoni-Ordóñez, Elizabeth Ortiz-Sánchez, Pedro Rosendo-Chalma, Heriberto A Valencia-González, Carmen Aceves and Alejandro García-Carrancá
    Citation: BMC Cancer 2018 18:928
    Content type: Research article Published on:

  5. There is a pressing need to reduce the burden of chronic disease and improve healthcare system sustainability through improved cancer and chronic disease prevention and screening (CCDPS) in primary care. We ai...

    Authors: Donna Patricia Manca, Carolina Fernandes, Eva Grunfeld, Kris Aubrey-Bassler, Melissa Shea-Budgell, Aisha Lofters, Denise Campbell-Scherer, Nicolette Sopcak, Mary Ann O’Brien, Christopher Meaney, Rahim Moineddin, Kerry McBrien, Ginetta Salvalaggio and Paul Krueger
    Citation: BMC Cancer 2018 18:927
    Content type: Study protocol Published on:

  6. Breast cancer is the most common cancer in women. 12–15% of all tumors are triple-negative breast cancers (TNBC). So far, TNBC has been mainly associated with mutations in BRCA1. The presence of other predispo...

    Authors: Juliane Hoyer, Georgia Vasileiou, Steffen Uebe, Marius Wunderle, Cornelia Kraus, Peter A. Fasching, Christian T. Thiel, Arndt Hartmann, Matthias W. Beckmann, Michael P. Lux and André Reis
    Citation: BMC Cancer 2018 18:926
    Content type: Research article Published on:

  7. Cervical cancer incidence and mortality is high in Uyghur ethnics. Their life style and dietary habit were different from other ethnics living together. Study on the role of trace elements in HPV infection and...

    Authors: Guzhalinuer Abulizi, Yuan-Yuan Zhang, Patiman Mijiti, Hua Li, Guzhalinuer Abuduxikuer, Jing Cai, Zhi-Hong Dong, Gulimire Naizhaer, Xiu-Wei Yang, Miherinisha Maimaiti, Ling-Lu, Guligeina Abudurexiti, Gulixian Tuerxun, Kailibinuer Aierken, Yu-Jie Jiang, Li-Li…
    Citation: BMC Cancer 2018 18:925
    Content type: Research article Published on:

  8. Greater family size measured with total fertility rate (TFR) and with household size, may offer more life satisfaction to the family members. Positive psychological well-being has been postulated to decrease c...

    Authors: Wenpeng You, Frank J Rühli, Renata J Henneberg and Maciej Henneberg
    Citation: BMC Cancer 2018 18:924
    Content type: Research article Published on:

  9. PRKAA1 encodes α-subunit of 5-AMP-activated protein kinase (AMPK), which has been implicated in the pathogenesis of carcinoma of the stomach. Previous works have suggested that polymorphisms in the PRKAA1 may be ...

    Authors: Minbin Chen, Baohu Jiang, Bangshun He, Min Tang, Ping Wang, Li Chen, Jianwei Lu and Peihua Lu
    Citation: BMC Cancer 2018 18:923
    Content type: Research article Published on:

  10. Protein kinase inhibitors (PKIs) are currently tested in clinical studies (phase I-III) as an alternative strategy against (recurrent) ovarian cancer. Besides their anti-tumour efficacy, several PKIs have also...

    Authors: Dennis Lindenblatt, Nastassja Terraneo, Giovanni Pellegrini, Susan Cohrs, Philipp René Spycher, David Vukovic, Martin Béhé, Roger Schibli and Jürgen Grünberg
    Citation: BMC Cancer 2018 18:922
    Content type: Research article Published on:

  11. Perianal Paget’s disease (PPD) is a rare intraepithelial adenocarcinoma of the anal margin. Primary PPD likely represents intra-epithelial neoplasm from an apocrine source, whereas secondary disease may repres...

    Authors: Jéssica Silva dos Santos, Gabriel Alves Bonafé, José Aires Pereira, Danilo Toshio Kanno, Carlos Augusto Real Martinez and Manoela Marques Ortega
    Citation: BMC Cancer 2018 18:921
    Content type: Case report Published on:

  12. Hospitalized cancer patients undergoing intensive or high-dose chemotherapy often experience a considerable decline in functional performance associated with the increased risk of adverse health events. Exerci...

    Authors: Antonia Pahl, Anja Wehrle, Sarah Kneis, Albert Gollhofer and Hartmut Bertz
    Citation: BMC Cancer 2018 18:920
    Content type: Research article Published on:

  13. Hepatocellular carcinoma (HCC) is a common malignant tumor with high fatality rate. Recent studies reported that up-regulation of long non-coding RNA antisense non-coding RNA in the INK4 locus (lncRNA ANRIL) w...

    Authors: Deyu Huang, Chunhua Bi, Qingxi Zhao, Xueli Ding, Cheng Bian, Hui Wang, Ting Wang and Hua Liu
    Citation: BMC Cancer 2018 18:919
    Content type: Research article Published on:

  14. Total P16 methylation (P16M), including P16 hydroxymethylation (P16H) and true-P16M, correlates with malignant transformation of oral epithelial dysplasia (OED). Both true-P16M and P16H are early events in carcin...

    Authors: Hongwei Liu, Zhaojun Liu, Xue-wei Liu, Si Xu, Lei Wang, Yang Liu, Jing Zhou, Liankun Gu, Yan Gao, Xiao-yong Liu, Huidong Shi, Zheng Sun and Dajun Deng
    Citation: BMC Cancer 2018 18:918
    Content type: Research article Published on:

  15. Febrile neutropenia (FN) is a common occurrence during chemotherapy. Granulocyte colony-stimulating factors (G-CSFs) can significantly reduce the risk of FN. International guidelines recommend G-CSF for patien...

    Authors: Bernardo Leon Rapoport, Matti Aapro, Marianne Paesmans, Ronwyn van Eeden, Teresa Smit, Andriy Krendyukov and Jean Klastersky
    Citation: BMC Cancer 2018 18:917
    Content type: Study protocol Published on:

  16. Patients undergoing chemotherapy are highly burdened by side effects. These may be caused by the pharmacodynamics of the drug or be driven by psychological factors such as negative expectations or pre-conditio...

    Authors: Julia Quidde, Yiqi Pan, Melanie Salm, Armin Hendi, Sven Nilsson, Karin Oechsle, Alexander Stein and Yvonne Nestoriuc
    Citation: BMC Cancer 2018 18:916
    Content type: Study protocol Published on:

  17. Biannual ultrasound (US)—with or without alpha-fetoprotein (AFP)—is recommended by current guidelines for the surveillance of hepatocellular carcinoma (HCC). However, the inadequate sensitivity of US has been ...

    Authors: Chansik An, Do Young Kim, Jin-Young Choi, Kwang Hyub Han, Yun Ho Roh and Myeong-Jin Kim
    Citation: BMC Cancer 2018 18:915
    Content type: Study protocol Published on:

  18. Immunochemical fecal occult blood tests (iFOBTs) are increasingly used for colorectal cancer (CRC) screening. In our preceding observational study, sensitivity for detecting advanced colorectal neoplasms by iF...

    Authors: Kaja Tikk, David Czock, Walter E. Haefeli, Annette Kopp-Schneider and Hermann Brenner
    Citation: BMC Cancer 2018 18:914
    Content type: Study protocol Published on:

  19. Soft tissue sarcomas are a heterogeneous and rare group of solid tumors of mesenchymal origin that can arise anywhere in the body. Although surgical resection is the mainstay of treatment for patients with loc...

    Authors: Emily Z. Keung, Alexander J. Lazar, Keila E. Torres, Wei-Lien Wang, Janice N. Cormier, B. Ashleigh Guadagnolo, Andrew J. Bishop, Heather Lin, Kelly K. Hunt, Justin Bird, Valerae O. Lewis, Shreyaskumar R. Patel, Jennifer A. Wargo, Neeta Somaiah and Christina L. Roland
    Citation: BMC Cancer 2018 18:913
    Content type: Study protocol Published on:

  20. Women diagnosed with gynaecological cancer experience supportive care needs that require care provision to reduce the impact on their lives. International evidence suggests supportive care needs of women with ...

    Authors: Natalie Williams, Georgia Griffin, Victoria Farrell, Alethea Rea, Kevin Murray and Yvonne L. Hauck
    Citation: BMC Cancer 2018 18:912
    Content type: Research article Published on:

  21. Traditional therapeutics have encountered a bottleneck caused by diagnosis delay and subjective and unreliable assessment. Biomarkers can overcome this bottleneck and guide us toward personalized precision med...

    Authors: Liang Zhong, Yutong Liu, Kai Wang, Zhijing He, Zhaojian Gong, Zhili Zhao, Yaocheng Yang, Xiaofei Gao, Fangjie Li, Hanjiang Wu, Sheng Zhang and Lin Chen
    Citation: BMC Cancer 2018 18:911
    Content type: Review Published on:

  22. The combination of chemotherapy and L-asparaginase (L-ASP) treatment significantly increased survival rate in an adult patient with extranodal natural killer (NK)/T-cell lymphoma (NKTCL). However, hypersensitivit...

    Authors: Wen Zheng, Yuhuan Gao, Xiaoyan Ke, Weijing Zhang, Liping Su, Hanyun Ren, Ningjing Lin, Yan Xie, Meifeng Tu, Weiping Liu, Lingyan Ping, Zhitao Ying, Chen Zhang, Lijuan Deng, Xiaopei Wang, Yuqin Song…
    Citation: BMC Cancer 2018 18:910
    Content type: Research article Published on:

  23. This study aimed to investigate the clinical utility of serum and histological MMP-9 detection during neoadjuvant chemotherapy (NAC) for triple-negative breast cancer (TNBC).

    Authors: Ruo-Xi Wang, Sheng Chen, Liang Huang and Zhi-Ming Shao
    Citation: BMC Cancer 2018 18:909
    Content type: Research article Published on:

  24. Although there has been marked development in surgical techniques, there is no easy and fast method of predicting complications in minimally invasive surgeries. We evaluated whether the modified surgical Apgar...

    Authors: Seon Hee Park, Jung-Yun Lee, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim and Young Tae Kim
    Citation: BMC Cancer 2018 18:908
    Content type: Research article Published on:

  25. The treatment recommendations for Low-grade Gliomas (LGG) underwent profound changes due to results from RTOG 9802 published in April 2016. This work aims to investigate whether the results from the trial were...

    Authors: Christoph Straube, Kerstin A. Kessel, Friederike Schmidt-Graf, Sandro M. Krieg, Bernhard Meyer, Jens Gempt and Stephanie E. Combs
    Citation: BMC Cancer 2018 18:907
    Content type: Research article Published on:

  26. Colorectal cancer (CRC) is an illness strongly influenced by sex and gender, with mortality rates in males significantly higher than females. There is still a dearth of understanding on where sex differences e...

    Authors: Alan White, Lucy Ironmonger, Robert J. C. Steele, Nick Ormiston-Smith, Carina Crawford and Amanda Seims
    Citation: BMC Cancer 2018 18:906
    Content type: Research article Published on:

  27. Endometriosis is a relatively common condition in women of reproductive age. Malignant transformation of intestinal endometriosis is a very rare event. We report a case in which a patient with a history of end...

    Authors: Ningning Li, Weixun Zhou, Lin Zhao and Jiaolin Zhou
    Citation: BMC Cancer 2018 18:905
    Content type: Case report Published on:

  28. There is an urgent need for more novel and efficacious therapeutic agents and strategies for the treatment of ovarian cancer - one of the most formidable female malignancies. These approaches should be based o...

    Authors: Vsevolod I. Kiselev, Levon A. Ashrafyan, Ekaterina L. Muyzhnek, Evgeniya V. Gerfanova, Irina B. Antonova, Olga I. Aleshikova and Fazlul H. Sarkar
    Citation: BMC Cancer 2018 18:904
    Content type: Research article Published on:

  29. Magnetic resonance imaging (MRI) has improved capacity to visualize tumor and soft tissue involvement in head and neck cancers. Using advanced MRI, we can interrogate cell density using diffusion weighted imag...

    Authors: Sweet Ping Ng, Houda Bahig, Jihong Wang, Carlos E. Cardenas, Anthony Lucci, Carolyn S. Hall, Salyna Meas, Vanessa N. Sarli, Ying Yuan, Diana L. Urbauer, Yao Ding, Shane Ikner, Vi Dinh, Baher A. Elgohari, Jason M. Johnson, Heath D. Skinner…
    Citation: BMC Cancer 2018 18:903
    Content type: Study protocol Published on:

  31. Accelerated malignant behaviors induced by insufficient thermal ablation have been increasingly reported, however, the exact mechanisms are still unclear. Here, we investigated the importance of the extracellu...

    Authors: Rui Zhang, Min Ma, Xia-Hui Lin, Hua-Hua Liu, Jie Chen, Jun Chen, Dong-Mei Gao, Jie-Feng Cui, Zheng-Gang Ren and Rong-Xin Chen
    Citation: BMC Cancer 2018 18:901
    Content type: Research article Published on:

  32. Triple Negative Breast Cancer (TNBC) is an aggressive form of breast cancer, that represents 10–20% of all breast carcinomas and characterized by the lack of a specific cell surface marker compared to other br...

    Authors: Farah Jouali, Nabila Marchoudi, Salwa Talbi, Basma Bilal, Mohamed El Khasmi, Houria Rhaissi and Jamal Fekkak
    Citation: BMC Cancer 2018 18:900
    Content type: Research article Published on:

  33. Interactions between cancer cells and the surrounding microenvironment are crucial determinants of cancer progression. During this process, bi-directional communication among tumor cells and cancer associated ...

    Authors: Francesca Andriani, Elena Landoni, Mavis Mensah, Federica Facchinetti, Rosalba Miceli, Elda Tagliabue, Marta Giussani, Maurizio Callari, Loris De Cecco, Mario Paolo Colombo, Luca Roz, Ugo Pastorino and Gabriella Sozzi
    Citation: BMC Cancer 2018 18:899
    Content type: Research article Published on:

  34. Definitive chemoradiotherapy is standard of care in locally advanced cervical cancer (LACC). Both toxicity and local relapse remain major concerns in this treatment. We hypothesize that a magnetic resonance im...

    Authors: Katrien Vandecasteele, Philippe Tummers, Mieke Van Bockstal, Pieter De Visschere, Tom Vercauteren, Werner De Gersem, Hannelore Denys, Eline Naert, Amin Makar and Wilfried De Neve
    Citation: BMC Cancer 2018 18:898
    Content type: Study protocol Published on:

  35. The only available predictive models for the outcome of breast cancer patients in New Zealand (NZ) are based on data in other countries. We aimed to develop and validate a predictive model using NZ data for th...

    Authors: J. Mark Elwood, Essa Tawfiq, Sandar TinTin, Roger J. Marshall, Tung M. Phung, Ian Campbell, Vernon Harvey and Ross Lawrenson
    Citation: BMC Cancer 2018 18:897
    Content type: Research article Published on:

  36. Intestinal-type sinonasal adenocarcinomas (ITACs) are aggressive malignancies related to wood dust and leather exposure. ITACs are generally associated with advanced stage at presentation due to the insidious ...

    Authors: Marco Tomasetti, Massimo Re, Federica Monaco, Simona Gaetani, Corrado Rubini, Andrea Bertini, Ernesto Pasquini, Cristiana Bersaglieri, Massimo Bracci, Sara Staffolani, Mariastella Colomba, Armando Gregorini, Matteo Valentino, Adriano Tagliabracci, Massimo Bovenzi, Jiri Neuzil…
    Citation: BMC Cancer 2018 18:896
    Content type: Research article Published on:

  37. An emerging immunotherapy is infusion of tumor infiltrating Lymphocytes (TIL), with objective response rates of around 50% versus 19% for ipilimumab. As an Advanced Therapeutic Medicinal Products (ATMP), TIL i...

    Authors: Valesca P. Retèl, Lotte M. G. Steuten, Marnix H. Geukes Foppen, Janne C. Mewes, Melanie A. Lindenberg, John B. A. G. Haanen and Wim H. van Harten
    Citation: BMC Cancer 2018 18:895
    Content type: Research article Published on:

  38. Pseudogenes are RNA transcripts with high homology with its parent protein-coding genes. Although pseudogenes lost the ability to produce protein, it still exert import biological function, and play important ...

    Authors: Fengqiong Liu, Ruijie Gong, Baochang He, Fa Chen and Zhijian Hu
    Citation: BMC Cancer 2018 18:894
    Content type: Research article Published on:

  40. Frailty is an indicator of physiological reserve in older people. In non-cancer settings, frailty indices are reliable predictors of adverse health outcomes. The aims of this study were to 1) derive and valida...

    Authors: A. L. McCarthy, N. M. Peel, K. M. Gillespie, R. Berry, E. Walpole, P. Yates and R. E. Hubbard
    Citation: BMC Cancer 2018 18:892
    Content type: Research article Published on:

  41. Our goal was to investigate the prevalence of the epidermal growth factor receptor (EGFR) mutation in Middle East and African countries and to compare its prevalence with that shown in other populations.

    Authors: Zineb Benbrahim, Teresita Antonia and Nawfel Mellas
    Citation: BMC Cancer 2018 18:891
    Content type: Research article Published on:

  42. Accurate assessment of liver health prior to undertaking resectional liver surgery or chemoembolisation for primary and secondary cancers is essential for patient safety and optimal outcomes. LiverMultiScanâ„¢, an ...

    Authors: Damian J. Mole, Jonathan A. Fallowfield, Timothy J. Kendall, Fenella Welsh, Scott I. Semple, Velicia Bachtiar, Matt Kelly, Stephen J. Wigmore, O. James Garden, Henry R. Wilman, Rajarshi Banerjee, Myrddin Rees and Michael Brady
    Citation: BMC Cancer 2018 18:890
    Content type: Study protocol Published on:

  43. We report on a female patient who underwent primary radical resection for a stage 2B Her-2-positive Barrett’s-type esophageal adenocarcinoma (EAC). Despite Her-2 targeted therapy, her disease recurred and requ...

    Authors: Federica Isidori, Deborah Malvi, Silvia Fittipaldi, Claudio Forcato, Isotta Bozzarelli, Claudia Sala, Giovanni Raulli, Antonia D’Errico, Michelangelo Fiorentino, Marco Seri, Kausilia K. Krishnadath, Elena Bonora and Sandro Mattioli
    Citation: BMC Cancer 2018 18:889
    Content type: Case report Published on:

  44. Treatment with programmed cell death receptor (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors is a promising strategy to lift tumour-induced immune response suppression. However, the current syste...

    Authors: J. Rotman, C. H. Mom, E. S. Jordanova, T. D. de Gruijl and G. G. Kenter
    Citation: BMC Cancer 2018 18:888
    Content type: Study protocol Published on:

  45. Ameloblastoma is a slow-growing neoplasm of the jaw, for which the standard treatment is surgical removal of the lesion with high recurrence rates and elevated morbidity. Systemic therapy is not established in...

    Authors: Gustavo S. Fernandes, Daniel M. Girardi, João Paulo G. Bernardes, Felipe P. Fonseca and Eduardo R. Fregnani
    Citation: BMC Cancer 2018 18:887
    Content type: Case report Published on:

  46. Physical exercise and nutritional treatment are promising measures to prevent muscle wasting that is frequently observed in advanced-stage cancer patients. However, conventional exercise is not always suitable...

    Authors: Kristin Schink, Hans J. Herrmann, Raphaela Schwappacher, Julia Meyer, Till Orlemann, Elisabeth Waldmann, Bernd Wullich, Andreas Kahlmeyer, Rainer Fietkau, Dorota Lubgan, Matthias W. Beckmann, Carolin Hack, Wolfgang Kemmler, Jürgen Siebler, Markus F. Neurath and Yurdagül Zopf
    Citation: BMC Cancer 2018 18:886
    Content type: Research article Published on:

  47. Resection of the primary tumor is recommended for symptom relief in de novo stage IV breast cancer. We explored whether local surgery could provide a survival benefit in these patients and attempted to charact...

    Authors: Zhenchong Xiong, Guangzheng Deng, Jin Wang, Xing Li, Xinhua Xie, Zeyu Shuang and Xi Wang
    Citation: BMC Cancer 2018 18:885
    Content type: Research article Published on:

  48. The aim of this study was to develop nomograms for predicting the risk of locoregional recurrence or distant metastasis in esophageal cancer patients who were treated with esophagectomy and regional lymphadene...

    Authors: Wen-Yi Zhang, Xing-Xing Chen, Wen-Hao Chen, Hui Zhang and Chang-Lin Zou
    Citation: BMC Cancer 2018 18:879
    Content type: Research article Published on:

  50. Following publication of the original article [1], the authors reported that the affiliation of author Annalisa Orenti was omitted.

    Authors: Elisabetta Venturelli, Annalisa Orenti, Aline S. C. Fabricio, Giulia Garrone, Roberto Agresti, Biagio Paolini, Chiara Bonini, Massimo Gion, Franco Berrino, Christine Desmedt, Danila Coradini and Elia Biganzoli
    Citation: BMC Cancer 2018 18:876
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2018 18:651

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