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  1. Difficult resection of tumors from regions with complex local anatomy, such as the pelvis and sacrum, is likely to result in inadequate surgical margins (intralesional or marginal); this is because three-dimen...

    Authors: Kensaku Abe, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Hiroyuki Inatani, Yu Aoki, Takashi Higuchi, Yuta Taniguchi, Hirotaka Yonezawa, Yoshihiro Araki and Hiroyuki Tsuchiya
    Citation: BMC Cancer 2018 18:1036
    Content type: Case report Published on:

  2. Among cancer patients, prior antidepressant use has been associated with impaired survival. This could be due to differences in stage at diagnosis, in receipt of treatment, or in treatment complications. The p...

    Authors: Ellen Hollands Steffensen, Clint Cary, Jørgen Bjerggaard Jensen, Heidi Larsson, Michael Weiner and Mette Nørgaard
    Citation: BMC Cancer 2018 18:1035
    Content type: Research article Published on:

  3. Pancreatic cancer is a highly malignant tumor with a poor prognosis. Chemotherapy such as gemcitabine is still an important treatment. Gemcitabine (Gem) may prolong survival time and delay the development of r...

    Authors: Hua Chen, Ruizhi He, Xiuhui Shi, Min Zhou, Chunle Zhao, Hang Zhang and Renyi Qin
    Citation: BMC Cancer 2018 18:1034
    Content type: Research article Published on:

  4. Cavity occurs in 5.7 to 14.9% of patients with lung adenocarcinoma (ADC). However, the impact of cavity on the therapeutic response to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) in...

    Authors: Fei Zhou, Wanrong Ma, Wei Li, Huijuan Ni, Guanghui Gao, Xiaoxia Chen, Jie Zhang and Jingyun Shi
    Citation: BMC Cancer 2018 18:1033
    Content type: Research article Published on:

  5. It was demonstrated that long non-coding RNAs occupied an important position in tumor pathogenesis and progression. We have previously found that the metastasis-associated lung adenocarcinoma transcript 1 (MAL...

    Authors: Meng Zhuo, Cuncun Yuan, Ting Han, Jiujie Cui, Feng Jiao and Liwei Wang
    Citation: BMC Cancer 2018 18:1032
    Content type: Research article Published on:

  6. Androgen deprivation therapy (ADT) is commonly used to treat prostate cancer. However, side effects of ADT often lead to reduced quality of life and physical function. Existing evidence demonstrates that exerc...

    Authors: Shabbir M. H. Alibhai, Paul Ritvo, Daniel Santa Mina, Catherine Sabiston, Murray Krahn, George Tomlinson, Andrew Matthew, Himu Lukka, Padraig Warde, Sara Durbano, Meagan O’Neill and S. Nicole Culos-Reed
    Citation: BMC Cancer 2018 18:1031
    Content type: Study protocol Published on:

  7. Stereotactic ablative body radiotherapy (SABR) is a non-invasive alternative to surgery to control primary renal cell cancer (RCC) in patients that are medically inoperable or at high-risk of post-surgical dia...

    Authors: Shankar Siva, Brent Chesson, Mathias Bressel, David Pryor, Braden Higgs, Hayley M. Reynolds, Nicholas Hardcastle, Rebecca Montgomery, Ben Vanneste, Vincent Khoo, Jeremy Ruben, Eddie Lau, Michael S. Hofman, Richard De Abreu Lourenco, Swetha Sridharan, Nicholas R. Brook…
    Citation: BMC Cancer 2018 18:1030
    Content type: Study protocol Published on:

  8. Remodeling of Ca2+ signaling is an important step in cancer progression, and altered expression of members of the Ca2+ signaling toolkit including the plasma membrane Ca2+ ATPases (PMCA proteins encoded by ATP2B ...

    Authors: Karolina Varga, Anna Hollósi, Katalin Pászty, Luca Hegedűs, Gergely Szakács, József Tímár, Béla Papp, Ágnes Enyedi and Rita Padányi
    Citation: BMC Cancer 2018 18:1029
    Content type: Research article Published on:

  9. The RAS/RAF/MEK/ERK pathway is one of the most downregulated pathway in cancer. Inhibitors of RAF and MEK have established clinical use while ERK inhibitors recently faced the clinic. We aimed to generate resi...

    Authors: Alice Iezzi, Elisa Caiola, Arianna Scagliotti and Massimo Broggini
    Citation: BMC Cancer 2018 18:1028
    Content type: Research article Published on:

  10. P38 mitogen activated protein kinase is an intermediary signal transduction factor with context-specific roles in breast cancer. Recent mechanistic studies add to the growing consensus that P38 is a tumour sup...

    Authors: Simon J. Johnston, Dena Ahmad, Mohammed A. Aleskandarany, Sasagu Kurozumi, Chris C. Nolan, Maria Diez-Rodriguez, Andrew R. Green and Emad A. Rakha
    Citation: BMC Cancer 2018 18:1027
    Content type: Research article Published on:

  11. The evolution of radiotherapy over recent decades has reintroduced the hypofractionation for many tumor sites with similar outcomes to those of conventional fractionated radiotherapy. The use of hypofractionat...

    Authors: Alexandre Arthur Jacinto, Eronides Salustiano Batalha Filho, Luciano de Souza Viana, Pedro De Marchi, Renato de Castro Capuzzo, Ricardo Ribeiro Gama, Domingos Boldrini Junior, Carlos Roberto Santos, Gustavo Dix Junqueira Pinto, Josiane Mourão Dias, Heloisa Pelisser Canton, Raiany Carvalho, Lucas Augusto Radicchi, Soren Bentzen, Eduardo Zubizarreta and Andre Lopes Carvalho
    Citation: BMC Cancer 2018 18:1026
    Content type: Research article Published on:

  12. The dismal prognosis of patients with glioblastoma (GBM) is attributed to a rare subset of cancer stem cells that display characteristics of tumor initiation, growth, and resistance to aggressive treatment inv...

    Authors: Brian Tung, Ding Ma, Shuyan Wang, Olutobi Oyinlade, John Laterra, Mingyao Ying, Sheng-Qing Lv, Shuang Wei and Shuli Xia
    Citation: BMC Cancer 2018 18:1025
    Content type: Research article Published on:

  13. Merkel cell carcinoma (MCC) is a rare neuroendocrine malignancy of the skin characterized by high aggressiveness. Four main factors are implicated in its development: immunosuppression, ultraviolet radiation, ...

    Authors: Daniele Lavacchi, Stefania Nobili, Marco Brugia, Agnese Paderi, Sara Fancelli, Enrico Caliman, Federica Vergoni and Enrico Mini
    Citation: BMC Cancer 2018 18:1024
    Content type: Case report Published on:

  14. Tumor suppressor gene p16 promoter hypermethylation has been widely studied in colorectal cancer (CRC), yet its clinicopathological significance remains controversial. The methylation alterations of other regions...

    Authors: Xiaoxia Ye, Mingming Mo, Simin Xu, Qingjin Yang, Minhua Wu, Junjie Zhang, Bin Chen, Jian Li, Yu Zhong, Qionglin Huang and Chun Cai
    Citation: BMC Cancer 2018 18:1023
    Content type: Research article Published on:

  15. Colorectal cancer is a significant issue internationally, with over 1.3 million people diagnosed annually. Survival rates are increasing as treatments improve, although physical symptoms can persist despite er...

    Authors: Claire O’Gorman, Jim Stack, Alan O’Ceilleachair, Suzanne Denieffe, Martina Gooney, Martina McKnight and Linda Sharp
    Citation: BMC Cancer 2018 18:1022
    Content type: Research article Published on:

  16. To assess the prognostic factors and investigate the optimal treatment of gastric mixed adenoneuroendocrine tumors.

    Authors: Jian-Wei Xie, Jun Lu, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ze-Ning Huang, Ju-Li Lin, Chao-Hui Zheng, Ping Li and Chang-Ming Huang
    Citation: BMC Cancer 2018 18:1021
    Content type: Research article Published on:

  18. Nanoparticle albumin-bound (nab)-paclitaxel has better efficacy, safety profiles, and no need to use prophylactic steroids compared with solvent-based paclitaxel. We performed a single arm, phase II study to e...

    Authors: Yannan Zhao, Fangfang Lv, She Chen, Zhonghua Wang, Jian Zhang, Sheng Zhang, Jun Cao, Leiping Wang, Enying Cao, Biyun Wang and Xichun Hu
    Citation: BMC Cancer 2018 18:1019
    Content type: Research article Published on:

  19. Cancer survivors may be at increased risk of cardiovascular diseases, but little is known about whether prescribing guidelines for the primary prevention of cardiovascular disease are adequately implemented in...

    Authors: Kendal Chidwick, Helen Strongman, Anthony Matthews, Susannah Stanway, Alexander R. Lyon, Liam Smeeth and Krishnan Bhaskaran
    Citation: BMC Cancer 2018 18:1018
    Content type: Research article Published on:

  20. How patients recover and resume everyday life after curative hepato-pancreato-biliary (HPB) surgery with intestinal reconstruction has, to our knowledge, not previously been investigated. We wanted to explore ...

    Authors: Kristine Elberg Dengsø, Tine Tjørnhøj-Thomsen, Susanne Oksbjerg Dalton, Bo Marcel Christensen, Jens Hillingsø and Thordis Thomsen
    Citation: BMC Cancer 2018 18:1017
    Content type: Research article Published on:

  21. The Insulin-like growth factor (IGF) pathway plays a role in tumour development and progression. In vivo, IGF1 activity is regulated by the IGF binding proteins (IGFBPs). IGFBP4 inhibits the activity of IGF1 b...

    Authors: Y. E. Smith, S. Toomey, S. Napoletano, G. Kirwan, C. Schadow, A. J. Chubb, J. H. Mikkelsen, C. Oxvig and J. H. Harmey
    Citation: BMC Cancer 2018 18:1016
    Content type: Research article Published on:

  22. Shared decision-making (SDM) is recommended for men facing prostate cancer (PC) screening decisions. We synthesize the evidence on the comparative effectiveness of SDM with usual care.

    Authors: Nahara Anani Martínez-González, Stefan Neuner-Jehle, Andreas Plate, Thomas Rosemann and Oliver Senn
    Citation: BMC Cancer 2018 18:1015
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2018 18:1196

  23. MicroRNAs (miRNAs) are important regulators of cellular function and have been associated with both aging and cancer, but the impact of chemotherapy on age-related miRNAs has barely been studied.

    Authors: Bruna Dalmasso, Sigrid Hatse, Barbara Brouwers, Annouschka Laenen, Lieze Berben, Cindy Kenis, Ann Smeets, Patrick Neven, Patrick Schöffski and Hans Wildiers
    Citation: BMC Cancer 2018 18:1014
    Content type: Research article Published on:

  24. Territorial differences in the access to innovative anticancer drugs have been reported from many countries. The objectives of this study were to evaluate access to innovative treatments for metastatic lung ca...

    Authors: Arnaud Scherpereel, Isabelle Durand-Zaleski, François-Emery Cotté, Jérôme Fernandes, Didier Debieuvre, Cécile Blein, Anne-Françoise Gaudin, Charlène Tournier, Alexandre Vainchtock, Pierre Chauvin, Pierre-Jean Souquet, Virginie Westeel and Christos Chouaïd
    Citation: BMC Cancer 2018 18:1013
    Content type: Research article Published on:

  25. Compared with standard chemotherapy, epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are more effective in patients with advanced non-small-cell lung cancer (NSCLC) harboring EGFR mutat...

    Authors: Naoto Aiko, Tsuneo Shimokawa, Kazuhito Miyazaki, Yuki Misumi, Yoko Agemi, Mari Ishii, Yukiko Nakamura, Takeharu Yamanaka and Hiroaki Okamoto
    Citation: BMC Cancer 2018 18:1012
    Content type: Research article Published on:

  26. Peripheral monocyte count is an assessable parameter. Recently, evidence suggested an elevated preoperative monocyte counts predicting poor prognosis in malignancies. The aim of this study was to determine the...

    Authors: Yang Hai, Nan Chen, Wenwen Wu, Zihuai Wang, Feng Lin, Chenglin Guo, Chengwu Liu, Weimin Li and Lunxu Liu
    Citation: BMC Cancer 2018 18:1011
    Content type: Research article Published on:

  27. Receptor activator of nuclear factor kappa-B (RANK)-signaling is involved in tumor growth and spread in experimental models. Binding of RANK ligand (RANKL) to RANK activates signaling, which is inhibited by os...

    Authors: Danja Sarink, Helena Schock, Theron Johnson, Jenny Chang-Claude, Kim Overvad, Anja Olsen, Anne Tjønneland, Patrick Arveux, Agnès Fournier, Marina Kvaskoff, Heiner Boeing, Anna Karakatsani, Antonia Trichopoulou, Carlo La Vecchia, Giovanna Masala, Claudia Agnoli…
    Citation: BMC Cancer 2018 18:1010
    Content type: Research article Published on:

  28. NDRG2 is identified as a tumor suppressor gene in many tumors, and functions in cell proliferation, differentiation and apoptosis. Recent data indicate that NDRG2 expression is up-regulated by TP53. Moreover, pro...

    Authors: Yu-Qiong Yang, Tian Tian, Hua-Yuan Zhu, Jin-Hua Liang, Wei Wu, Jia-Zhu Wu, Yi Xia, Li Wang, Lei Fan, Jian-Yong Li and Wei Xu
    Citation: BMC Cancer 2018 18:1009
    Content type: Research article Published on:

  29. Renal impairment (RI) is a negative prognostic factor in Multiple Myeloma (MM) and affected patients are often excluded from autologous stem cell transplantation (ASCT). However, it remains unclear whether his...

    Authors: Marlies Antlanger, Tobias Dust, Thomas Reiter, Alexandra Böhm, Wolfgang W. Lamm, Max Gornicec, Ella Willenbacher, David Nachbaur, Roman Weger, Werner Rabitsch, Susanne Rasoul-Rockenschaub, Nina Worel, Daniel Lechner, Hildegard Greinix, Felix Keil, Heinz Gisslinger…
    Citation: BMC Cancer 2018 18:1008
    Content type: Research article Published on:

  30. Rigors are a significant adverse event during interleukin-2 (IL2) therapy for metastatic melanoma and renal cell carcinoma. Meperidine has been a mainstay for rigor prophylaxis but there is a paucity of data r...

    Authors: Brian Khong, Benjamin O. Lawson, Junjie Ma, Cheryl McGovern, Joan K. Van Atta, Abhijit Ray and Hung T. Khong
    Citation: BMC Cancer 2018 18:1007
    Content type: Research article Published on:

  31. Nearly one third of patients undergoing neoadjuvant chemoradiotherapy (nCRT) for locally advanced esophageal cancer have a pathologic complete response (pCR) of the primary tumor upon histopathological evaluat...

    Authors: A. S. Borggreve, S. Mook, M. Verheij, V. E. M. Mul, J. J. Bergman, A. Bartels-Rutten, L. C. ter Beek, R. G. H. Beets-Tan, R. J. Bennink, M. I. van Berge Henegouwen, L. A. A. Brosens, I. L. Defize, J. M. van Dieren, H. Dijkstra, R. van Hillegersberg, M. C. Hulshof…
    Citation: BMC Cancer 2018 18:1006
    Content type: Study protocol Published on:

  32. The aim of this study was to determine the HPV positivity rate in patients with laryngeal cancer, and to determine the effect of HPV positivity on survival. An additional aim was to determine if patients with ...

    Authors: Ozlem Onerci Celebi, Ebru Sener, Sefik Hosal, Mustafa Cengiz, Ibrahim Gullu and Gaye Guler Tezel
    Citation: BMC Cancer 2018 18:1005
    Content type: Research article Published on:

  33. The incidence of ocular metastasis from lung cancer is reported to be 0.1–7%, with adenocarcinoma and small cell lung cancer accounting for the highest proportions of these cases. The majority of cases involve...

    Authors: Ye Guo, Xu Wang, Jun Xiao, Yinghui Xu, Yangyang Cai, Chao Sun and Kewei Ma
    Citation: BMC Cancer 2018 18:1004
    Content type: Case report Published on:

  34. Sarcomas that arise from the scapula or periscapular soft tissues often require a total scapulectomy. This often implies a large complex tissue defect that needs adequate reconstruction of both bone and soft t...

    Authors: Giovanni Beltrami, Gabriele Ristori, Guido Scoccianti, Angela Tamburini, Rodolfo Capanna, Domenico Campanacci and Marco Innocenti
    Citation: BMC Cancer 2018 18:1003
    Content type: Case report Published on:

  35. Fear of cancer recurrence (FCR) has been shown to be higher in patients treated with external beam radiotherapy (RT) compared to those untreated. However, little is known about the dynamics of patient’s FCR du...

    Authors: Y. Yang, J. Cameron, C. Bedi and G. Humphris
    Citation: BMC Cancer 2018 18:1002
    Content type: Research article Published on:

  36. The evaluation of cervical lymph nodes is very important for patients with papillary thyroid carcinoma (PTC). Conventional ultrasound is recommended to assess the status of cervical lymph nodes but the diagnos...

    Authors: Wanying Chang, Lei Tang, Caiwei Lu, Min Wu and Man Chen
    Citation: BMC Cancer 2018 18:1001
    Content type: Research article Published on:

  37. Rituximab plus combination chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is broadly accepted as standard for the treatment of diffuse large B-cell lymphoma (DLBCL). Neve...

    Authors: Roland Christian Schelker, Wolfgang Herr, Albrecht Reichle and Martin Vogelhuber
    Citation: BMC Cancer 2018 18:1000
    Content type: Research article Published on:

  38. The tumour microenvironment conferred by mesenchymal stem cells (MSCs) plays a key role in tumour development and progression. We previously determined that platelet-activating factor receptor (PAFR) was overe...

    Authors: Tong Gao, Yi Yu, Qing Cong, Yisheng Wang, Mingming Sun, Liangqing Yao, Congjian Xu and Wei Jiang
    Citation: BMC Cancer 2018 18:999
    Content type: Research article Published on:

  39. Even though the post-operative outcome varies greatly among patients with nodal positive colon cancer (UICC stage III), personalized prediction of systemic disease recurrence is currently insufficient. We inve...

    Authors: Andreas Sperlich, Alexander Balmert, Dietrich Doll, Sabine Bauer, Fabian Franke, Gisela Keller, Dirk Wilhelm, Anna Mur, Michael Respondek, Helmut Friess, Ulrich Nitsche and Klaus-Peter Janssen
    Citation: BMC Cancer 2018 18:998
    Content type: Research article Published on:

  40. Systemic inflammation has been implicated in cancer development and progression. This study examined the best cutoff value of erythrocyte sedimentation rate (ESR) in diffuse large B-cell lymphoma (DLBCL) patie...

    Authors: Shuang Wu, Ye Zhou, Hai-Ying Hua, Yan Zhang, Wen-Yan Zhu, Zhi-Qing Wang, Jin Li, Hua-Qiang Gao, Xiao-Hong Wu, Ting-Xun Lu and Dong Hua
    Citation: BMC Cancer 2018 18:997
    Content type: Research article Published on:

  41. Epidemiologists are beginning to employ metabolomics and lipidomics with archived blood from incident cases and controls to discover causes of cancer. Although several such studies have focused on colorectal c...

    Authors: Kelsi Perttula, Courtney Schiffman, William M B Edmands, Lauren Petrick, Hasmik Grigoryan, Xiaoming Cai, Marc J Gunter, Alessio Naccarati, Silvia Polidoro, Sandrine Dudoit, Paolo Vineis and Stephen M Rappaport
    Citation: BMC Cancer 2018 18:996
    Content type: Research article Published on:

  42. Ceritinib demonstrated a statistically significant effect on the progression-free survival versus chemotherapy in patients with advanced anaplastic lymphoma kinase (ALK) rearrangement in non-small cell lung ca...

    Authors: Taizou Hirano, Akira koarai, Tomohiro Ichikawa, Teruyuki Sato, Takashi Ohe and Masakazu Ichinose
    Citation: BMC Cancer 2018 18:995
    Content type: Case report Published on:

  43. The number of patients requesting autologous breast reconstruction (ABR) after mastectomy for breast cancer has increased over the past decades. However, concern has been expressed about the oncological safety...

    Authors: Joachim Geers, Hans Wildiers, Katrien Van Calster, Annouschka Laenen, Giuseppe Floris, Marc Vandevoort, Gerd Fabre, Ines Nevelsteen and Ann Smeets
    Citation: BMC Cancer 2018 18:994
    Content type: Research article Published on:

  44. Epithelioid hemangioendothelioma is an exceedingly rare sarcoma often occurring as an indolent angiocentric vascular tumor at various anatomic sites. Few reports have evaluated large case series of epithelioid...

    Authors: Satoshi Shiba, Hiroshi Imaoka, Kazuhiko Shioji, Eiichiro Suzuki, Shigeru Horiguchi, Takeshi Terashima, Yasushi Kojima, Tatsuya Okuno, Yasutaka Sukawa, Kunihiko Tsuji, Kumiko Umemoto, Akinori Asagi, Akiko Todaka, Makoto Ueno, Masafumi Ikeda, Chigusa Morizane…
    Citation: BMC Cancer 2018 18:993
    Content type: Research article Published on:

  45. The imbalance between the action of the tissue inhibitors of matrix metalloproteinases (TIMPs) and the matrix metalloproteinases (MMPs) is one component of metastasis physiology. TIMP-1 overrides MMP-9 activit...

    Authors: Renato F. Ivanovic, Nayara I. Viana, Denis R. Morais, Caio Moura, Iran A. Silva, Katia R. Leite, José Pontes-Junior, William C. Nahas, Miguel Srougi and Sabrina T. Reis
    Citation: BMC Cancer 2018 18:992
    Content type: Research article Published on:

  46. Sarcomas are rare, heterogeneous tumours affecting patients of any age. Previous surveys describe that sarcoma patients report a significantly worse experience than those with common cancers. Consequently, Sar...

    Authors: Eugenie Younger, Olga Husson, Lindsey Bennister, Jeremy Whelan, Roger Wilson, Andy Roast, Robin L Jones and Winette TA van der Graaf
    Citation: BMC Cancer 2018 18:991
    Content type: Research article Published on:

  47. Home parenteral nutrition (HPN) can improve survival, quality of life, nutritional and functional status in cancer patients. Bioelectrical impedance analysis (BIA) is a non-invasive, validated method to assess...

    Authors: Paolo Cotogni, Taira Monge, Maurizio Fadda and Antonella De Francesco
    Citation: BMC Cancer 2018 18:990
    Content type: Research article Published on:

  50. Although peripheral blood-based parameters (PBBPs) are reported as prognostic indicators in patients with breast cancers, their utility has not been studied in human epidermal growth factor receptor 2 (HER2)-p...

    Authors: Kazuhiro Araki, Yoshinori Ito, Ippei Fukada, Kokoro Kobayashi, Yoshimasa Miyagawa, Michiko Imamura, Ayako Kira, Yuichi Takatsuka, Chiyomi Egawa, Hirofumi Suwa, Shinji Ohno and Yasuo Miyoshi
    Citation: BMC Cancer 2018 18:982
    Content type: Research article Published on:

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