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  1. Prostate cancer (PCa) is the most common diagnosed malignancy and the second leading cause of cancer-related deaths among men in the United States. High-throughput genotyping has enabled discovery of germline ...

    Authors: Tarun Karthik Kumar Mamidi, Jiande Wu and Chindo Hicks
    Citation: BMC Cancer 2019 19:229
    Content type: Research article Published on:

  2. Gastric cancer (GC) is one of the most commonly occuring gastrointestinal tumor types, and early diagnosis and operation have a notable effect on the prognosis of patients. Although certain markers, including ...

    Authors: Jiaxin Liu, Zhao Liu, Xiaozhi Zhang, Tuotuo Gong and Demao Yao
    Citation: BMC Cancer 2019 19:227
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:759

  3. Glucose metabolism has been suggested as a therapeutic target in ovarian clear cell carcinoma (CCC). We attempted to clarify 18F-FDG PET/CT-based metabolic metrics in the recurrent ovarian CCC patients and their ...

    Authors: Shuang Ye, Shuai Liu, Libing Xiang, Xiaohua Wu and Huijuan Yang
    Citation: BMC Cancer 2019 19:226
    Content type: Research article Published on:

  4. This study aimed to determine whether the enhancer of the rudimentary homolog (ERH) gene regulates cell migration and invasion in human bladder urothelial carcinoma (BUC) T24 cells and the underlying mechanism.

    Authors: Kun Pang, Zhiguo Zhang, Lin Hao, Zhenduo Shi, Bo Chen, Guanghui Zang, Yang Dong, Rui Li, Ying Liu, Jie Wang, Jianjun Zhang, Longjun Cai, Xiaoxiao Han and Conghui Han
    Citation: BMC Cancer 2019 19:225
    Content type: Research article Published on:

  5. Our previous works have demonstrated that 8-bromo-7-methoxychrysin suppressed stemness of human hepatocellular carcinoma (HCC) cell line SMMC-7721 induced by condition medium from hepatic stellate cell line LX...

    Authors: Qi Wen, Chang Xu, Jie Zhou, Nuo-Min Liu, Ying-Hong Cui, Mei-Fang Quan, Jian-Guo Cao and Kai-qun Ren
    Citation: BMC Cancer 2019 19:224
    Content type: Research article Published on:

  6. Previous studies have demonstrated that β2-microglobulin (β2M) promotes the growth and survival of a variety of cancer cells and has different regulatory effects on the expression of Bcl-2 and HER2 in HER2− breas...

    Authors: Dandan Chai, Kesheng Li, Huifen Du, Suisheng Yang, Rong Yang, Yang Xu and Xiaowen Lian
    Citation: BMC Cancer 2019 19:223
    Content type: Research article Published on:

  7. Non-small cell lung cancer (NSCLC) as the most frequent type of lung cancer is associated with extensive mortality. Researchers have studied the suitability of several molecules as biomarkers for early detecti...

    Authors: Farbod Esfandi, Mohammad Taheri, Mir Davood Omrani, Mohammad Behgam Shadmehr, Shahram Arsang-Jang, Roshanak Shams and Soudeh Ghafouri-Fard
    Citation: BMC Cancer 2019 19:222
    Content type: Research article Published on:

  8. Locally advanced uterine cervical cancer (LAUCC) with lateral tumor extension may not always be covered adequately by conventional intracavitary brachytherapy (ICBT). Hybrid intracavitary and interstitial brac...

    Authors: Naoya Murakami, Kazuma Kobayashi, Satoshi Shima, Keisuke Tsuchida, Tairo Kashihara, Nikolaos Tselis, Rei Umezawa, Kana Takahashi, Koji Inaba, Yoshinori Ito, Hiroshi Igaki, Yuko Nakayama, Koji Masui, Ken Yoshida, Tomoyasu Kato and Jun Itami
    Citation: BMC Cancer 2019 19:221
    Content type: Research article Published on:

  9. Breast cancer patient-derived xenograft (BC-PDX) models represent a continuous and reproducible source of circulating tumor cells (CTCs) for studying their role in tumor biology and metastasis. We have previou...

    Authors: Arturo B. Ramirez, Raksha Bhat, Debashish Sahay, Carmine De Angelis, Hariprasad Thangavel, Sina Hedayatpour, Lacey E. Dobrolecki, Agostina Nardone, Mario Giuliano, Chandandeep Nagi, Mothaffar Rimawi, C. Kent Osborne, Michael T. Lewis, Jackie L. Stilwell, Eric P. Kaldjian, Rachel Schiff…
    Citation: BMC Cancer 2019 19:220
    Content type: Research article Published on:

  10. Breast cancer is a highly heterogeneous disease resulting in diverse clinical behaviours and therapeutic responses. DNA methylation is a major epigenetic alteration that is commonly perturbed in cancers. The a...

    Authors: Bernardo P. de Almeida, Joana Dias Apolónio, Alexandra Binnie and Pedro Castelo-Branco
    Citation: BMC Cancer 2019 19:219
    Content type: Research article Published on:

  11. Over 1.3 million people live with colorectal cancer in the United States. Physical activity is associated with lower risk of colorectal cancer recurrence and mortality. Interventions are needed to increase phy...

    Authors: Erin L. Van Blarigan, Hilary Chan, Katherine Van Loon, Stacey A. Kenfield, June M. Chan, Emily Mitchell, Li Zhang, Alan Paciorek, Galen Joseph, Angela Laffan, Chloe E. Atreya, Yoshimi Fukuoka, Christine Miaskowski, Jeffrey A. Meyerhardt and Alan P. Venook
    Citation: BMC Cancer 2019 19:218
    Content type: Research article Published on:

  12. 0.17–2% of mature cystic teratoma of the ovary (MCTO) undergo malignant transformation, of which 80% are squamous cell carcinoma (SCC) transformation in MCTO. We aim to investigate the clinical characteristics...

    Authors: Congcong Li, Qing Zhang, Siying Zhang, Ruifen Dong, Chenggong Sun, Chunping Qiu, Zhiwei Zhang, Xingsheng Yang and Beihua Kong
    Citation: BMC Cancer 2019 19:217
    Content type: Research article Published on:

  13. This study sought to explore whether lymphovascular invasion can affect the prognosis of patients with stage N0 gastric cancer and to evaluate the survival benefit of adjuvant chemotherapy for such patients.

    Authors: Jun Lu, Yun Dai, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Chao-Hui Zheng, Ping Li and Chang-Ming Huang
    Citation: BMC Cancer 2019 19:216
    Content type: Research article Published on:

  14. PAM50 gene profiling assigns each cancer to a single intrinsic subtype. However, individual cancers vary in their adherence to a prototype, and due to bulk tissue sampling, some may exhibit expression patterns...

    Authors: Neeraj Kumar, Dan Zhao, Dulal Bhaumik, Amit Sethi and Peter H. Gann
    Citation: BMC Cancer 2019 19:215
    Content type: Research article Published on:

  16. Although surgical resection provides a cure for patients with intrahepatic cholangiocarcinoma (ICC), the risk of mortality and recurrence remains high. Several biomarkers are reported to be associated with the...

    Authors: Chao Bi, Mei Liu, Weiqi Rong, Fan Wu, Yang Zhang, Shengtao Lin, Yunhe Liu, Jianxiong Wu and Liming Wang
    Citation: BMC Cancer 2019 19:213
    Content type: Research article Published on:

  17. The gastric cancer incidence rate differs widely across geographical areas. In Italy, in the province of Cremona the incidence is high, compared to the national situation. For this reason a specialized populat...

    Authors: B. M. Donida, G. Tomasello, M. Ghidini, F. Buffoli, M. Grassi, W. Liguigli, G. Maglietta, L. Pergola, M. Ratti, G. Sabadini, L. Toppo, M. Ungari and R. Passalacqua
    Citation: BMC Cancer 2019 19:212
    Content type: Research article Published on:

  18. The Na+/H+ exchanger (NHE1) plays a crucial role in cancer cell proliferation and metastasis. However, the mechanism underlying chemotherapeutic resistance in cancer cells has not been completely elucidated. The ...

    Authors: Qi Chen, Yueqin Liu, Xiao-lan Zhu, Fan Feng, Hui Yang and Wenlin Xu
    Citation: BMC Cancer 2019 19:211
    Content type: Research article Published on:

  19. Recurrence is not explicitly documented in cancer registry data that are widely used for research. Patterns of events after initial treatment such as oncology visits, re-operation, and receipt of subsequent ch...

    Authors: Yuan Xu, Shiying Kong, Winson Y. Cheung, Antoine Bouchard-Fortier, Joseph C. Dort, Hude Quan, Elizabeth M. Buie, Geoff McKinnon and May Lynn Quan
    Citation: BMC Cancer 2019 19:210
    Content type: Research article Published on:

  20. MicroRNA-148b (miR-148b) has been detected in various types of tumors, and is generally viewed as a tumor suppressor. Our previous study found the decreased expression of miR-148b in human non small cell lung ...

    Authors: Lin Lu, Qiyao Liu, Peipei Wang, Yong Wu, Xia Liu, Chengyin Weng, Xisheng Fang, Baoxiu Li, Xiaofei Cao, Haibo Mao, Lina Wang, Mingmei Guan, Wei Wang and Guolong Liu
    Citation: BMC Cancer 2019 19:209
    Content type: Research article Published on:

  21. Tumor-associated lymphangiogenesis is considered significant in number of solid malignancies. However, its impact on prognosis of intrahepatic cholangiocarcinoma (ICC) after resection remains further confirmat...

    Authors: Meng Sha, Seogsong Jeong, Xin Wang, Ying Tong, Jie Cao, Han-Yong Sun, Lei Xia, Ning Xu, Zhi-Feng Xi, Jian-Jun Zhang, Xiao-Ni Kong and Qiang Xia
    Citation: BMC Cancer 2019 19:208
    Content type: Research article Published on:

  22. The role of eosinophils in cancer is not yet completely understood, but patients with eosinophilia show a trend towards longer survival in several types of cancer, including melanoma. However, eosinophil count...

    Authors: Annika Krückel, Alvaro Moreira, Waltraud Fröhlich, Gerold Schuler and Lucie Heinzerling
    Citation: BMC Cancer 2019 19:207
    Content type: Research article Published on:

  23. KLASS (the Korean Laparoendoscopic Gastrointestinal Surgery Study) is a time-honored study group that has established laparoscopic surgery for gastrointestinal disease in Korea and has performed some important...

    Authors: Chang Min Lee, Ji Ho Park, Chang In Choi, Han Hong Lee, Jae-Seok Min, Ye Seob Jee, Oh. Jeong, Hyundong Chae, Sung Il Choi, Hua Huang and Sungsoo Park
    Citation: BMC Cancer 2019 19:206
    Content type: Study protocol Published on:

  24. Triple-negative breast cancer (TNBC) represents an aggressive subtype with limited therapeutic options. Experimental preclinical models that recapitulate their tumors of origin can accelerate target identifica...

    Authors: Margarite D. Matossian, Hope E. Burks, Steven Elliott, Van T. Hoang, Annie C. Bowles, Rachel A. Sabol, Bahia Wahba, Muralidharan Anbalagan, Brian Rowan, Mohamed E. Abazeed, Bruce A. Bunnell, Krzysztof Moroz, Lucio Miele, Lyndsay V. Rhodes, Steven D. Jones, Elizabeth C. Martin…
    Citation: BMC Cancer 2019 19:205
    Content type: Research article Published on:

  25. Heterogeneity in bladder cancer results in variable clinical outcomes, posing challenges for clinical management of this malignancy. Recent studies suggest both tumor suppressive and oncogenic role of PPARγ in...

    Authors: Shidong Lv, Wei Wang, Hongyi Wang, Yongtong Zhu and Chengyong Lei
    Citation: BMC Cancer 2019 19:204
    Content type: Research article Published on:

  27. The tumor suppressor protein phosphatase and tensin homolog (PTEN) is a key regulator of the PI3K/AKT pathway which is frequently altered in a variety of tumors including a subset of acute B-lymphoblastic leuk...

    Authors: Anna Richter, Catrin Roolf, Mohamed Hamed, Yvonne Saara Gladbach, Sina Sender, Christoph Konkolefski, Gudrun Knübel, Anett Sekora, Georg Fuellen, Brigitte Vollmar, Hugo Murua Escobar and Christian Junghanss
    Citation: BMC Cancer 2019 19:202
    Content type: Research article Published on:

  28. The clinical and experimental evidences for complement-cancer relationships are solid, whereas an epidemiological study reporting the imbalance of complement system in patients is still lacking.

    Authors: Ping Zhao, Jun Wu, Feiteng Lu, Xuan Peng, Chenlin Liu, Nanjin Zhou and Muying Ying
    Citation: BMC Cancer 2019 19:201
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:269

  29. Cancer immunotherapy with immune checkpoint blockade (CKB) is now standard of care for multiple cancers. The clinical response to CKB is associated with T cell immunity targeting cancer-induced mutations that ...

    Authors: Pooja Narang, Meixuan Chen, Amit A. Sharma, Karen S. Anderson and Melissa A. Wilson
    Citation: BMC Cancer 2019 19:200
    Content type: Research article Published on:

  30. The length of interval between successive childbirths (birth interval) might influence the incidence of breast cancer, either by stimulating or by inhibiting the factors that are responsible for the initiation...

    Authors: Sushmita Katuwal, Juha S. Tapanainen, Eero Pukkala and Antti Kauppila
    Citation: BMC Cancer 2019 19:199
    Content type: Research article Published on:

  31. Despite multimodality treatments including neurosurgery, radiotherapy and chemotherapy, glioblastoma (GBM) prognosis remains poor. GBM is classically considered as a radioresistant tumor, because of its high l...

    Authors: Paul Lesueur, Justine Lequesne, Jean-Michel Grellard, Audrey Dugué, Elodie Coquan, Pierre-Emmanuel Brachet, Julien Geffrelot, William Kao, Evelyne Emery, David Hassanein Berro, Laurent Castera, Nicolas Goardon, Joëlle Lacroix, Marie Lange, Aurélie Capel, Alexandra Leconte…
    Citation: BMC Cancer 2019 19:198
    Content type: Study protocol Published on:

  32. The cytosine deaminase (CD)/5-fluorocytosine (5-FC) system is among the best explored enzyme/prodrug systems in the field of the suicide gene therapy. Recently, by the screening of the environmental metagenomi...

    Authors: Arunas Kazlauskas, Adas Darinskas, Rolandas Meškys, Arimantas Tamašauskas and Jaunius Urbonavičius
    Citation: BMC Cancer 2019 19:197
    Content type: Research article Published on:

  33. Treatment options for advanced thyroid cancer refractory to standard therapies are limited. The safety and efficacy of pembrolizumab were evaluated in patients with advanced differentiated thyroid cancer expre...

    Authors: Janice M. Mehnert, Andrea Varga, Marcia S. Brose, Rahul R. Aggarwal, Chia-Chi Lin, Amy Prawira, Filippo de Braud, Kenji Tamura, Toshihiko Doi, Sarina A. Piha-Paul, Jill Gilbert, Sanatan Saraf, Pradeep Thanigaimani, Jonathan D. Cheng and Bhumsuk Keam
    Citation: BMC Cancer 2019 19:196
    Content type: Research article Published on:

  34. Chemoradiotherapy effectively treats superficial esophageal cancer and is optimal to preserve organs. However, late toxicity, particularly in cardiac diseases, obstructs clinical outcomes. We revealed the risk...

    Authors: Yoshito Hayashi, Hideki Iijima, Fumiaki Isohashi, Yoshiki Tsujii, Tetsuji Fujinaga, Kengo Nagai, Shunsuke Yoshii, Akihiko Sakatani, Satoshi Hiyama, Shinichiro Shinzaki, Tomoki Makino, Makoto Yamasaki, Kazuhiko Ogawa, Yuichiro Doki and Tetsuo Takehara
    Citation: BMC Cancer 2019 19:195
    Content type: Research article Published on:

  36. Microtubule-associated protein Tau (MAPT) overexpression has been linked to poor prognosis and decreased response to taxane-based therapies in several cancer types, but its relevance in prostate cancer is unkn...

    Authors: Cornelia Schroeder, Jan Grell, Claudia Hube-Magg, Martina Kluth, Dagmar Lang, Ronald Simon, Doris Höflmayer, Sarah Minner, Eike Burandt, Till S. Clauditz, Franziska Büscheck, Frank Jacobsen, Hartwig Huland, Markus Graefen, Thorsten Schlomm, Guido Sauter…
    Citation: BMC Cancer 2019 19:193
    Content type: Research article Published on:

  37. Central nervous system lymphomas (CNSL) is a devastating disease. Currently, a confirmatory biopsy is required prior to treatment.

    Authors: Anne-Katrin Hickmann, Maximilian Frick, Dirk Hadaschik, Florian Battke, Markus Bittl, Oliver Ganslandt, Saskia Biskup and Dennis Döcker
    Citation: BMC Cancer 2019 19:192
    Content type: Case report Published on:

  38. Primary cardiac lymphomas (PCL) represent extremely rare cardiac tumors which are accompanied by poor prognosis, unless they are timely diagnosed and treated.

    Authors: Maria Bonou, Chris J. Kapelios, Athanasios Marinakos, Stamatis Adamopoulos, Panagiotis Diamantopoulos, Periklis G. Foukas, Loukas Kaklamanis, Penelope Korkolopoulou, John Barbetseas and Nora-Athina Viniou
    Citation: BMC Cancer 2019 19:191
    Content type: Case report Published on:

  39. IDH1/2 mutated glioma has been associated with a germline risk variant, the rs55705857 G allele. The Utah Population Database (UPDB), a computerized genealogy of people in Utah, is a unique resource to evaluate c...

    Authors: Sarah Hummel, Wendy Kohlmann, Thomas M. Kollmeyer, Robert Jenkins, Joshua Sonnen, Cheryl A. Palmer, Howard Colman, Diana Abbott, Lisa Cannon-Albright and Adam L. Cohen
    Citation: BMC Cancer 2019 19:190
    Content type: Research article Published on:

  41. It has been demonstrated that relatively small variations of the parameters of exposure to extremely low frequency magnetic fields (ELF-MF) can change significantly the outcome of experiments. Hence, either in...

    Authors: Leonardo Makinistian, Eva Marková and Igor Belyaev
    Citation: BMC Cancer 2019 19:188
    Content type: Research article Published on:

  42. Current prognostic markers cannot adequately predict the clinical outcome of breast cancer patients. Therefore, additional biomarkers need to be included in routine immune panels. FOXA1 was a significant predi...

    Authors: Shahin De Lara, Jenny Nyqvist, Elisabeth Werner Rönnerman, Khalil Helou, Elisabeth Kenne Sarenmalm, Zakaria Einbeigi, Per Karlsson, Toshima Z. Parris and Anikó Kovács
    Citation: BMC Cancer 2019 19:187
    Content type: Research article Published on:

  43. Pneumatosis intestinalis is a rare adverse event that occurs in patients with lung cancer, especially those undergoing treatment with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI). Osi...

    Authors: Yuki Nukii, Atsushi Miyamoto, Sayaka Mochizuki, Shuhei Moriguchi, Yui Takahashi, Kazumasa Ogawa, Kyoko Murase, Shigeo Hanada, Hironori Uruga, Hisashi Takaya, Nasa Morokawa and Kazuma Kishi
    Citation: BMC Cancer 2019 19:186
    Content type: Case report Published on:

  44. Cholangiocarcinomas are a heterogeneous group of malignancies arising from a number of cells of origin along the biliary tree. Although most cases in Western countries are sporadic, large population-based stud...

    Authors: Peter L. Labib, George Goodchild and Stephen P. Pereira
    Citation: BMC Cancer 2019 19:185
    Content type: Review Published on:

  45. Philadelphia (Ph) chromosome-negative myeloproliferative neoplasms (MPNs) are a heterogeneous group of hematopoietic stem cell clonal diseases. Most patients with MPN are asymptomatic at diagnosis although som...

    Authors: Tarinee Rungjirajittranon, Weerapat Owattanapanich, Patompong Ungprasert, Noppadol Siritanaratkul and Theera Ruchutrakool
    Citation: BMC Cancer 2019 19:184
    Content type: Research article Published on:

  46. VEGF/VEGFR2 pathway is the central therapeutic target in anti-angiogenic treatment in multiple cancers. However, little work has been carried out concerning the pro-malignancy functions of VEGFR2 that are inde...

    Authors: Lian Lian, Xiang-Li Li, Meng-Dan Xu, Xian-Min Li, Meng-Yao Wu, Yan Zhang, Min Tao, Wei Li, Xiao-Ming Shen, Chong Zhou and Min Jiang
    Citation: BMC Cancer 2019 19:183
    Content type: Research article Published on:

  47. Primary paediatric epidural sarcomas are extremely rare. Overall, there remains a paucity of knowledge in paediatric epidural sarcomas owing to the infrequent number of cases. The Archer FusionPlex Sarcoma Kit...

    Authors: Sharon Y. Y. Low, Chik Hong Kuick, Wan Yi Seow, Nurfahanah Bte Syed Sulaiman, Huiyi Chen, Derrick W. Q. Lian, Kenneth T. E. Chang, Enrica E. K. Tan, Shui Yen Soh, Grace I. L. Tan, Lee Ping Ng, Wan Tew Seow and David C. Y. Low
    Citation: BMC Cancer 2019 19:182
    Content type: Case report Published on:

  48. Colorectal cancer (CRC) is one of the most common cancers worldwide, and genetic variations exert distinct roles in its pathogenesis. Single nucleotide polymorphisms (SNPs) in interleukin 1 alpha (IL1A) were repo...

    Authors: Hong Ji, Le Lu, Jingjing Huang, Yang Liu, Binchao Zhang, Hui Tang, Dangze Sun, Yafei Zhang, Hao Shang, Yiming Li and Hongwei Lu
    Citation: BMC Cancer 2019 19:181
    Content type: Research article Published on:

  49. Inguinal lymph node metastasis from rectum is uncommon but well-known occurrence, whereas that from colon adenocarcinoma is extremely rare. Inguinal lymph node metastasis from colon adenocarcinoma has only bee...

    Authors: Taro Tanabe, Dai Shida, Shunsuke Tsukamoto, Goki Morizono, Hirokazu Taniguchi and Yukihide Kanemitsu
    Citation: BMC Cancer 2019 19:180
    Content type: Case report Published on:

  50. Our objective was to identify risk factors affecting overall survival (OS) and cancer-specific survival (CSS) and build nomograms to predict survival based on a large population-based cohort.

    Authors: Chaobin He, Yu Zhang, Zhiyuan Cai and Xiaojun Lin
    Citation: BMC Cancer 2019 19:178
    Content type: Research article Published on:

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