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  1. A first-line biologic treatment for metastatic colorectal cancer (mCRC) is still controversial. We, therefore, performed a meta-analysis to determine the efficacy of first-line cetuximab versus bevacizumab for...

    Authors: Bobo Zheng, Xin Wang, Mingtian Wei, Quan Wang, Jiang Li, Liang Bi, Xiangbing Deng and Ziqiang Wang
    Citation: BMC Cancer 2019 19:280
    Content type: Research article Published on:

  2. With poor prognosis and limited treatment options for advanced hepatocellular carcinoma (HCC), development of novel therapeutic agents is urgently needed. This single-arm phase I study sought to assess the saf...

    Authors: Ying Fan, Shu Li, Xiaoyan Ding, Jian Yue, Jun Jiang, Hong Zhao, Rui Hao, Weiliang Qiu, Kezhen Liu, Ying Li, Shengdian Wang, Limin Zheng, Bin Ye, Kun Meng and Binghe Xu
    Citation: BMC Cancer 2019 19:279
    Content type: Research article Published on:

  3. Codrituzumab, a humanized monoclonal antibody against Glypican-3 (GPC3), which is expressed in hepatocellular carcinoma (HCC), was tested in a randomized phase II trial in advanced HCC patients who had failed ...

    Authors: Melanie F. Pradier, Bernhard Reis, Lori Jukofsky, Francesca Milletti, Toshihiko Ohtomo, Fernando Perez-Cruz and Oscar Puig
    Citation: BMC Cancer 2019 19:278
    Content type: Research article Published on:

  4. The efficacy of bevacizumab combined with erlotinib (B + E) for the treatment of advanced hepatocellular carcinoma, especially for sorafenib-refractory patients, has been observed and evaluated in several tria...

    Authors: Liyun He, Huan Deng, Jun Lei, Fengming Yi, Jine Li, Xiu De Fan, Yiping Wei, Jianjun Xu and Wenxiong Zhang
    Citation: BMC Cancer 2019 19:276
    Content type: Research article Published on:

  5. Hepatocellular carcinoma (HCC) accounts for 75–85% of primary liver cancers and is prevalent in the Asia-Pacific region. Till now, trans-arterial chemoembolization (TACE) is still one of common modalities in m...

    Authors: Liang-Cheng Chen, Wen-Yen Chiou, Hon-Yi Lin, Moon-Sing Lee, Yuan-Chen Lo, Li-Wen Huang, Chun-Ming Chang, Tsung-Hsing Hung, Chih-Wen Lin, Kuo-Chih Tseng, Dai-Wei Liu, Feng-Chun Hsu and Shih-Kai Hung
    Citation: BMC Cancer 2019 19:275
    Content type: Study protocol Published on:

  6. There is limited information on changes over time in carcinoid syndrome (CS) symptoms and quality of life (QoL). This study assessed change in CS symptoms and QoL in patients treated with somatostatin analogs ...

    Authors: Daniel M. Halperin, Lynn Huynh, Jennifer L. Beaumont, Beilei Cai, Rachel H. Bhak, Sahil Narkhede, Todor Totev, Mei S. Duh, Maureen P. Neary and David Cella
    Citation: BMC Cancer 2019 19:274
    Content type: Research article Published on:

  7. Programmed cell death receptor 1 ligand 1 (PD-L1) expression in various tumors, including hematologic malignancies, has recently become a research topic of great interest. We performed a meta-analysis to evalu...

    Authors: Liping Qiu, Hanlu Zheng and Xiaoying Zhao
    Citation: BMC Cancer 2019 19:273
    Content type: Research article Published on:

  8. Physical activity (PA) is a safe and effective strategy to help mitigate health challenges associated with breast cancer (BC) survivorship. However, the majority of BC survivors are not meeting the minimum rec...

    Authors: Cristina M. Caperchione, Catherine M. Sabiston, Sean Stolp, Joan L. Bottorff, Kristin L. Campbell, Neil D. Eves, Susan L. Ellard, Carolyn Gotay, Paul Sharp, Tanya Pullen and Kayla M. Fitzpatrick
    Citation: BMC Cancer 2019 19:272
    Content type: Research article Published on:

  9. Atypical squamous cell of undetermined significance (ASCUS) is a common cervical cytological diagnosis. At present, HPV DNA assay is used to triage these patients, but its lower specificity brings a series of ...

    Authors: Yuanhang Zhu, Chenchen Ren, Li Yang, Xiaoan Zhang, Ling Liu and Zhaoxin Wang
    Citation: BMC Cancer 2019 19:271
    Content type: Research article Published on:

  10. Cardiovascular medications may be associated with cancer development, but little is known about their association with cancer recurrence. Medications such as statins and antihypertensives may be commonly used ...

    Authors: Erin J. A. Bowles, Onchee Yu, Rebecca Ziebell, Lu Chen, Denise M. Boudreau, Debra P. Ritzwoller, Rebecca A. Hubbard, Jennifer M. Boggs, Andrea N. Burnett-Hartman, Andrew Sterrett, Monica Fujii and Jessica Chubak
    Citation: BMC Cancer 2019 19:270
    Content type: Research article Published on:

  11. Following publication of the original article [1], it was noticed that Fig. 3c was omitted from the final published article.

    Authors: Ping Zhao, Jun Wu, Feiteng Lu, Xuan Peng, Chenlin Liu, Nanjin Zhou and Muying Ying
    Citation: BMC Cancer 2019 19:269
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2019 19:201

  13. Data from population-based cancer registries (PBCRs) are a useful resource for estimating the incidence of cancers. PBCR data is useful in the planning and implementation of cancer prevention and control strat...

    Authors: Yaw Ampem Amoako, Baffour Awuah, Rita Larsen-Reindorf, Fred Kwame Awittor, Gloria Kyem, Kwame Ofori-Boadu, Ernest Osei-Bonsu and Dennis Odai Laryea
    Citation: BMC Cancer 2019 19:267
    Content type: Research article Published on:

  14. Recent advances in the treatment of melanoma that involve immunotherapy and B-Raf inhibition have revolutionised cancer care for this disease. However, an un-met clinical need remains in B-Raf inhibitor resist...

    Authors: Connor M. Blair, Nicola M. Walsh, Bruce H. Littman, Frank W. Marcoux and George S. Baillie
    Citation: BMC Cancer 2019 19:266
    Content type: Research article Published on:

  15. Human papillomavirus (HPV) is an established risk factor for oropharyngeal squamous cell carcinoma (OSCC). The aim was to establish cell lines from HPV-positive tonsil carcinomas to be used for treatment devel...

    Authors: Ola Forslund, Natsuki Sugiyama, Chengjun Wu, Naveen Ravi, Yuesheng Jin, Sabine Swoboda, Fredrik Andersson, Davit Bzhalava, Emilie Hultin, Kajsa Paulsson, Joakim Dillner, Stefan Schwartz, Johan Wennerberg and Lars Ekblad
    Citation: BMC Cancer 2019 19:265
    Content type: Research article Published on:

  16. Multiple myeloma is a haematological malignancy characterized by significant morbidity and mortality. This study sought to develop an in-depth understanding of patients’ lived experiences of relapsed or refrac...

    Authors: Janet A. Parsons, Nicole R. Greenspan, Natalie A. Baker, Chris McKillop, Lisa K. Hicks and Olivia Chan
    Citation: BMC Cancer 2019 19:264
    Content type: Research article Published on:

  17. Lung adenocarcinoma is the most common type of lung cancers. Whole-genome sequencing studies disclosed the genomic landscape of lung adenocarcinomas. however, it remains unclear if the genetic alternations cou...

    Authors: Jiaxian Yu, Yueming Hu, Yafei Xu, Jue Wang, Jiajie Kuang, Wei Zhang, Jianlin Shao, Dianjing Guo and Yejun Wang
    Citation: BMC Cancer 2019 19:263
    Content type: Research article Published on:

  18. Epithelial-mesenchymal transition (EMT) may be one of the reasons for the failure in some clinical trials regarding histone deacetylase inhibitors (HDACIs)-treated solid tumors. We investigated the effects of ...

    Authors: Zhihua Shen, Xiaomin Liao, Zhongming Shao, Muyin Feng, Jianling Yuan, Sisi Wang, Siyuan Gan, Yanping Ha, Zhiwei He and Wei Jie
    Citation: BMC Cancer 2019 19:262
    Content type: Research article Published on:

  19. The immune system is a crucial component in cancer progression or regression. Molecular iodine (I2) exerts significant antineoplastic effects, acting as a differentiation inductor and immune modulator, but its ef...

    Authors: Irasema Mendieta, Rosa E. Nuñez-Anita, Mario Nava-Villalba, Xóchitl Zambrano-Estrada, Evangelina Delgado-González, Brenda Anguiano and Carmen Aceves
    Citation: BMC Cancer 2019 19:261
    Content type: Research article Published on:

  20. Following publication of the original article [1], the author noticed that there are some errors with Table 1 and Table 2. Please see the correct tables below. The authors apologize for any inconvenience caused.

    Authors: Cong Hua, Gang Zhao, Yunqian Li and Li Bie
    Citation: BMC Cancer 2019 19:260
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2014 14:526

  21. Though the management of malignancies has improved vastly in recent years, many treatment options lack the desired efficacy and fail to adequately augment patient morbidity and mortality. It is increasingly cl...

    Authors: Andrew Riley, Victoria Green, Ramsah Cheah, Gordon McKenzie, Laszlo Karsai, James England and John Greenman
    Citation: BMC Cancer 2019 19:259
    Content type: Research article Published on:

  22. The oncoprotein MYC has the dual capacity to drive cell cycle progression or induce apoptosis, depending on the cellular context. BAG1 was previously identified as a transcriptional target of MYC that function...

    Authors: Victoria J. Gennaro, Helen Wedegaertner and Steven B. McMahon
    Citation: BMC Cancer 2019 19:258
    Content type: Research article Published on:

  23. Following publication of the original article [1], the author noticed the following errors in the article.

    Authors: Wenxing Chen, Yanhong Pan, Siliang Wang, Yuping Liu, Guangying Chen, Liang Zhou, Chao Zhang, Wenting Ni, Aiyun Wang, Yin Lu and Shile Huang
    Citation: BMC Cancer 2019 19:257
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2017 17:34

  24. To systematically assess the prevalence of BRCA1 and BRCA2 gene mutations in women with Hereditary Breast and/or Ovarian Cancer (HBOC) in Arab countries and to describe the variability in the BRCA gene mutatio...

    Authors: Khadiga Abdulrashid, Nour AlHussaini, Wifag Ahmed and Lukman Thalib
    Citation: BMC Cancer 2019 19:256
    Content type: Research article Published on:

  25. In the era of genome-guided personalized cancer treatment, we must understand chemotherapy-induced genomic changes in tumors. This study evaluated whether adjuvant FOLFOX chemotherapy modifies the mutational p...

    Authors: Kazuaki Harada, Wataru Okamoto, Sachiyo Mimaki, Yasuyuki Kawamoto, Hideaki Bando, Riu Yamashita, Satoshi Yuki, Takayuki Yoshino, Yoshito Komatsu, Atsushi Ohtsu, Naoya Sakamoto and Katsuya Tsuchihara
    Citation: BMC Cancer 2019 19:255
    Content type: Research article Published on:

  26. Approximately 20–30% of patients with pT4 colon cancer develop metachronous peritoneal metastases (PM). Due to restricted accuracy of imaging modalities and absence of early symptoms, PM are often detected at ...

    Authors: Vivian P. Bastiaenen, Charlotte E. L. Klaver, Niels F. M. Kok, Johannes H. W. de Wilt, Ignace H. J. T. de Hingh, Arend G. J. Aalbers, Djamila Boerma, Andre J. A. Bremers, Jacobus W. A. Burger, Eino B. van Duyn, Pauline Evers, Wilhelmina M. U. van Grevenstein, Patrick H. J. Hemmer, Eva V. E. Madsen, Petur Snaebjornsson, Jurriaan B. Tuynman…
    Citation: BMC Cancer 2019 19:254
    Content type: Study protocol Published on:

  27. Despite its relatively low incidence, pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer deaths because of the aggressive growth/metastasis of the tumor, the lack of early symptoms, and the p...

    Authors: Jesse Bakke, William C. Wright, Anthony E. Zamora, Peter Oladimeji, Jeremy Chase Crawford, Christopher T. Brewer, Robert J. Autry, William E. Evans, Paul G. Thomas and Taosheng Chen
    Citation: BMC Cancer 2019 19:253
    Content type: Research article Published on:

  28. Carbohydrate antigen (CA) 19–9 levels after resection are considered to predict prognosis; however, the significance of decreased CA19–9 levels after neoadjuvant therapy has not been clarified. This study aime...

    Authors: Shuichi Aoki, Fuyuhiko Motoi, Yoshiaki Murakami, Masayuki Sho, Sohei Satoi, Goro Honda, Kenichiro Uemura, Ken-ichi Okada, Ippei Matsumoto, Minako Nagai, Hiroaki Yanagimoto, Masanao Kurata, Takumi Fukumoto, Masamichi Mizuma, Hiroki Yamaue and Michiaki Unno
    Citation: BMC Cancer 2019 19:252
    Content type: Research article Published on:

  29. Dexamethasone is widely used in cancer patients despite the concern that perioperative glucocorticoids may potentially cause immunosuppression. However, studies on the influence of dexamethasone on cancer recu...

    Authors: Myoung Hwa Kim, Dong Wook Kim, Seho Park, Joo Heung Kim, Ki Young Lee, Jisung Hwang and Young Chul Yoo
    Citation: BMC Cancer 2019 19:251
    Content type: Research article Published on:

  30. Although men carry a higher risk of hepatocellular carcinoma (HCC) than women, it is still controversial whether men also have a poorer postoperative prognosis. A retrospective study was conducted to evaluate ...

    Authors: Ming-Wei Lai, Yu-De Chu, Chih-Lang Lin, Rong-Nan Chien, Ta-Sen Yeh, Tai-Long Pan, Po-Yuan Ke, Kwang-Hui Lin and Chau-Ting Yeh
    Citation: BMC Cancer 2019 19:250
    Content type: Research article Published on:

  31. CanAssist-Breast is an immunohistochemistry based test that predicts risk of distant recurrence in early-stage hormone receptor positive breast cancer patients within first five years of diagnosis. Immunohisto...

    Authors: Arun Kumar Attuluri, Chandra Prakash V. Serkad, Aparna Gunda, Charusheila Ramkumar, Chetana Basavaraj, Ljubomir Buturovic, Lekshmi Madhav, Nirupama Naidu, Naveen Krishnamurthy, R. Prathima, Suchita Kanaldekar and Manjiri M. Bakre
    Citation: BMC Cancer 2019 19:249
    Content type: Research article Published on:

  32. Garlic has been used for centuries for its flavour and health promoting properties that include protection against cancer. The vinyl disulfide-sulfoxide ajoene is one of the phytochemicals found in crushed clo...

    Authors: Catherine H. Kaschula, Rosanna Tuveri, Ellen Ngarande, Kevin Dzobo, Christopher Barnett, Daniel A. Kusza, Lisa M. Graham, Arieh A. Katz, Mohamed Suhail Rafudeen, M. Iqbal Parker, Roger Hunter and Georgia Schäfer
    Citation: BMC Cancer 2019 19:248
    Content type: Research article Published on:

  33. Swainsonine is a natural indolizidine alkaloid, its anti-tumor activity has been widely reported in varied cancers. This study aimed to investigate whether Swainsonine exerted anti-tumor impact on glioma cells...

    Authors: Libo Sun, Xingyi Jin, Lijuan Xie, Guangjun Xu, Yunxia Cui and Zhuo Chen
    Citation: BMC Cancer 2019 19:247
    Content type: Research article Published on:

  34. Docetaxel is a widely used cytotoxic agent for treatments of various cancers. The ATP binding cassette (ABC) transporter / multidrug resistance protein (MRP) ABCC10/MRP7, involved in transporting taxanes, has ...

    Authors: Kazuki Sone, Tetsuya Oguri, Takehiro Uemura, Akira Takeuchi, Satoshi Fukuda, Osamu Takakuwa, Ken Maeno, Kensuke Fukumitsu, Yoshihiro Kanemitsu, Hirotsugu Ohkubo, Masaya Takemura, Yutaka Ito and Akio Niimi
    Citation: BMC Cancer 2019 19:246
    Content type: Research article Published on:

  35. Fine-needle aspiration (FNA) is the most reliable method for diagnosing thyroid nodules; however, some features such as atypia of undetermined significance or follicular lesion of undetermined significance can...

    Authors: Masanori Teshima, Kazuya Tokita, Eijitsu Ryo, Fumihiko Matsumoto, Madoka Kondo, Yota Ikegami, Hirotaka Shinomiya, Naoki Otsuki, Nobuyoshi Hiraoka, Ken-ichi Nibu, Seiichi Yoshimoto and Taisuke Mori
    Citation: BMC Cancer 2019 19:245
    Content type: Research article Published on:

  36. Nonseminomatous germ cell tumors (NSGCTs) represent one of the main groups of germ cell tumors (GCTs), and they have a more invasive course than seminomatous GCTs. Human immunodeficiency virus (HIV) positivity...

    Authors: Ruili Li and Hongjun Li
    Citation: BMC Cancer 2019 19:244
    Content type: Case report Published on:

  37. High-risk neuroblastoma with N-Myc amplification remains a therapeutic challenge in paediatric oncology. Antagonism of pro-death Bcl-2 homology (BH) proteins to pro-survival BH members such as Mcl-1 and Bcl-2 ...

    Authors: Stefanie Klenke, Neval Akdeli, Patrick Stelmach, Lukas Heukamp, Johannes H. Schulte and Hagen S. Bachmann
    Citation: BMC Cancer 2019 19:243
    Content type: Research article Published on:

  38. Patients with relapsed/refractory acute myeloid leukemia after hematopoietic stem cell transplantation (HSCT) have a poor prognosis, with a 2-year survival rate of 14%. The optimal treatment for these patients...

    Authors: Mengqi Jin, Yongxian Hu, Wenjun Wu, Yi Luo, Yamin Tan, Jian Yu, Aiyun Jin, Luxin Yang, He Huang and Guoqing Wei
    Citation: BMC Cancer 2019 19:242
    Content type: Case report Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:486

  39. Growing evidence indicates that inflammation contributes to cancer progression, and several inflammatory markers have been reported to be associated with the clinical outcomes in patients with various types of...

    Authors: Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Shinji Matsutani, Kenjiro Kimura, Ryosuke Amano, Kosei Hirakawa and Masaichi Ohira
    Citation: BMC Cancer 2019 19:241
    Content type: Research article Published on:

  40. Since Mesenchymal epithelial transition (MET) amplification has been regarded as a potential treatment target, the knowledge of its prevalence and prognostic importance is crucial. However, its clinical pathologi...

    Authors: Yanqiu Wang, Zhengzeng Jiang, Chen Xu, Hao Wang, Lijie Tan, Jieakesu Su, Xin Wang, Dongxian Jiang, Yingyong Hou and Qi Song
    Citation: BMC Cancer 2019 19:240
    Content type: Research article Published on:

  41. Cancer indicators are essential information for cancer surveillance and cancer research strategy development. The Martinique Cancer Registry (MCR) is a population-based cancer Registry (PBCR) that has been rec...

    Authors: Clarisse Joachim, Jacqueline Veronique-Baudin, Stephen Ulric-Gervaise, Audrey Pomier, Aimée Pierre-Louis, Mylène Vestris, Jean-Luc Novella, Moustapha Drame, Jonathan Macni and Patrick Escarmant
    Citation: BMC Cancer 2019 19:239
    Content type: Research article Published on:

  42. The purpose of the present study was to characterize the prevalence, associated factors, and to construct a nomogram for predicting bone metastasis (BM) with different histological types of lung cancer.

    Authors: Chao Zhang, Min Mao, Xu Guo, Ping Cui, Lianmin Zhang, Yao Xu, Lili Li, Xiuxin Han, Karl Peltzer, Shunbin Xiong, Vladimir P. Baklaushev, Xin Wang and Guowen Wang
    Citation: BMC Cancer 2019 19:238
    Content type: Research article Published on:

  44. Perivascular Epithelioid Cell Tumors (PEComa) is an extraordinarily rare mesenchymal neoplasm especially the malignant type originating from the lung. To date, only 8 cases of malignant or malignant potential ...

    Authors: Jikai Zhao, Haohua Teng, Ruiying Zhao, Wenjie Ding, Keke Yu, Lei Zhu, Jie Zhang and Yuchen Han
    Citation: BMC Cancer 2019 19:235
    Content type: Case report Published on:

  45. Cancer progression is influenced by a pro-tumorigenic microenvironment. The aberrant tumor stroma with increased collagen deposition, contractile fibroblasts and dysfunctional vessels has a major impact on the...

    Authors: Hilde Ytre-Hauge Smeland, Ning Lu, Tine V. Karlsen, Gerd Salvesen, Rolf K. Reed and Linda Stuhr
    Citation: BMC Cancer 2019 19:234
    Content type: Research article Published on:

  46. Gastric cancer receives considerable attention not only because it is the most common cancer all through the world, but also because it’s on the top third leading reason for cancer-related death. Lidocaine is ...

    Authors: Hongyang Sui, Anfeng Lou, Zhisong Li and Jianjun Yang
    Citation: BMC Cancer 2019 19:233
    Content type: Research article Published on:

  47. Alternative lengthening of telomeres (ALT) is a telomerase-independent mechanism used by a broad range of neoplasms to maintain telomere length, permitting uncontrolled replication during their progression. AL...

    Authors: Rita T. Lawlor, Nicola Veronese, Antonio Pea, Alessia Nottegar, Lee Smith, Camilla Pilati, Jacopo Demurtas, Matteo Fassan, Liang Cheng and Claudio Luchini
    Citation: BMC Cancer 2019 19:232
    Content type: Research article Published on:

  48. Advanced esophageal squamous cell cancer (ESCC) is frequently diagnosed in elderly patients. The impact of 2nd line chemotherapy is poorly defined. Recent data demonstrated effectiveness of checkpoint inhibito...

    Authors: Nadja M. Meindl-Beinker, Johannes Betge, Tobias Gutting, Elke Burgermeister, Sebastian Belle, Tianzuo Zhan, Nadine Schulte, Martin Maenz, Matthias P. Ebert and Nicolai Haertel
    Citation: BMC Cancer 2019 19:231
    Content type: Study protocol Published on:

  49. Breast cancer is the most common cancer in women worldwide, with a great diversity in outcomes among individual patients. The ability to accurately predict a breast cancer outcome is important to patients, phy...

    Authors: Minh Tung Phung, Sandar Tin Tin and J. Mark Elwood
    Citation: BMC Cancer 2019 19:230
    Content type: Research article Published on:

  50. Despite strong evidence of benefit, breast cancer risk assessment and chemoprevention are underutilized by primary care physicians. This study evaluates the impact of an educational program on knowledge and ut...

    Authors: Siddhartha Yadav, Sarah Hartkop, Paola Yumpo Cardenas, Rand Ladkany, Alexandra Halalau, Sandor Shoichet, Michael Maddens and Dana Zakalik
    Citation: BMC Cancer 2019 19:228
    Content type: Research article Published on:

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