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  1. Background: Benign breast lesions are the most common diseases in adult women, which have been treated with minimally invasive therapies in recent years. Little is known about the feasibility of Microwave abla...

    Authors: Wei Zhang, Zhan-Qiang Jin, Masoud Baikpour, Jian-Min Li, Hui Zhang, Ting Liang, Xiao-Ming Pan and Wen He
    Citation: BMC Cancer 2019 19:345
    Content type: Research article Published on:

  2. Incidence of renal dysfunction and risks of progression to end-stage renal disease (ESRD) were reported higher in upper urinary tract urothelial carcinoma (UTUC) than in renal cell carcinoma (RCC) patients aft...

    Authors: Sheng-Wen Niu, Peir-In Liang, Ming-Yen Lin, Shih-Meng Yeh, Yen-Yi Zhen, Yu-Han Chang, Pin-Chia Huang, Chi-Chi Hung, I-Ching Kuo, Hugo You-Hsien Lin, Mei-Chuan Kuo, Wei-Ming Li, Chun-Nung Huang, Wen-Jeng Wu, Li-Tzong Chen, Yi-Wen Chiu…
    Citation: BMC Cancer 2019 19:337
    Content type: Research article Published on:

  3. Abscopal effect is the out-of-field response to localized irradiation therapy that results in systemic antitumorigenic effects such as the regression of a tumor distant from the target site.

    Authors: Aoi Kuroda, Takaya Tabuchi, Eri Iwami, Kotaro Sasahara, Tatsu Matsuzaki, Takahiro Nakajima, Yuki Tsutsumi, Keisuke Eguchi and Takeshi Terashima
    Citation: BMC Cancer 2019 19:336
    Content type: Case report Published on:

  4. Here we describe the treatments and prognosis for metachronous metastases from gastroenteropancreatic neuroendocrine tumors (GEP-NETs) after initial R0 surgical resection at a large center in China.

    Authors: Yang Lv, Xu Han, Xue-Feng Xu, Yuan Ji, Yu-Hong Zhou, Hui-Chuan Sun, Jian Zhou, Jia Fan, Wen-Hui Lou and Cheng Huang
    Citation: BMC Cancer 2019 19:335
    Content type: Research article Published on:

  5. Our aim was to determine the epidemiology and recent changes in the trends of non-functional pancreatic neuroendocrine tumours (NF-pNETs) at the population level. In addition, we explored the risk factors that...

    Authors: Junjun Wu, Chi Sun, Enliang Li, Jiakun Wang, Xianping He, Rongfa Yuan, Chenghao Yi, Wenjun Liao and Linquan Wu
    Citation: BMC Cancer 2019 19:334
    Content type: Research article Published on:

  6. Visceral organ metastasis is associated with poor survival outcomes in terms of metastasis free- and overall survival in breast carcinomas. Identification of a gene expression profile in tumours that selects a...

    Authors: C. D. Savci-Heijink, H. Halfwerk, J. Koster, H. M. Horlings and M. J. van de Vijver
    Citation: BMC Cancer 2019 19:333
    Content type: Research article Published on:

  7. The treatment of patients with glioma depended on the nature of the lesion and on histological grade of the tumor. Positron emission tomography (PET) using 13N-ammonia (NH3), 11C-methionine (MET) and 18F-fluorode...

    Authors: Qiao He, Linqi Zhang, Bing Zhang, Xinchong Shi, Chang Yi and Xiangsong Zhang
    Citation: BMC Cancer 2019 19:332
    Content type: Research article Published on:

  8. Non-muscular invasive bladder cancer (NMIBC) has a high risk of recurrence. As androgen receptor (AR) reportedly affects bladder cancer, we assessed the correlation between NMIBC recurrence and tumor AR expressio...

    Authors: Masato Yasui, Takashi Kawahara, Koji Izumi, Masahiro Yao, Yukari Ishiguro, Hitoshi Ishiguro, Hiroji Uemura and Yasuhide Miyoshi
    Citation: BMC Cancer 2019 19:331
    Content type: Research article Published on:

  9. Decisions made in multidisciplinary tumor conferences (MTC) that consider patient preferences result in better patient outcomes. Furthermore, it has been shown that in some breast cancer centers in Germany, pa...

    Authors: Christian Heuser, Annika Diekmann, Christoph Kowalski, Anna Enders, Rupert Conrad, Holger Pfaff, Lena Ansmann and Nicole Ernstmann
    Citation: BMC Cancer 2019 19:330
    Content type: Research article Published on:

  10. In this study, the influence of the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) on the prognosis of giant cell tumor (GCT) of the extremities were investigated.

    Authors: Zhenhao Chen, Guanglei Zhao, Feiyan Chen, Jun Xia and Li Jiang
    Citation: BMC Cancer 2019 19:329
    Content type: Research article Published on:

  11. Cancer cells evolve and constitute heterogeneous populations that fluctuate in space and time and are subjected to selection generating intratumor heterogeneity. This phenomenon is determined by the acquisitio...

    Authors: Emanuel M. Campoy, María T. Branham, Luis S. Mayorga and María Roqué
    Citation: BMC Cancer 2019 19:328
    Content type: Research article Published on:

  12. Recurrences are reported in 70% of all patients after resection of colorectal liver metastases (CRLM), in which half are confined to the liver. Adjuvant hepatic arterial infusion pump (HAIP) chemotherapy aims ...

    Authors: F. E. Buisman, M. Y. V. Homs, D. J. Grünhagen, W. F. Filipe, R. J. Bennink, M. G. H. Besselink, I. H. M. Borel Rinkes, R. C. G. Bruijnen, A. Cercek, M. I. D’Angelica, O. M. van Delden, M. L. Donswijk, L. van Doorn, P. G. Doornebosch, J. Emmering, J. I. Erdmann…
    Citation: BMC Cancer 2019 19:327
    Content type: Study protocol Published on:

  14. For progressive metastatic medullary thyroid carcinoma (MTC), the available treatment options with tyrosine kinase inhibitors result in grade 3–4 adverse events in a large number of patients. Peptide Receptor ...

    Authors: Carolien M. Beukhof, Tessa Brabander, Francien H. van Nederveen, Marie-Louise F. van Velthuysen, Yolanda B. de Rijke, Leo J. Hofland, Gaston J. H. Franssen, Lideke A. C. Fröberg, Boen L. R. Kam, W. Edward Visser, Wouter W. de Herder and Robin P. Peeters
    Citation: BMC Cancer 2019 19:325
    Content type: Research article Published on:

  15. We are reporting a rare case of MUTYH-associated polyposis, a colorectal cancer hereditary syndrome, diagnosticated after an intussusception. Colorectal cancer is an important cause of cancer related mortality...

    Authors: Gustavo Heluani Antunes de Mesquita, Bárbara Justo Carvalho, Kayo Augusto de Almeida Medeiros, Fernanda Nii, Diego Ramos Martines, Leonardo Zumerkorn Pipek, Yuri Justi Jardim, Daniel Reis Waisberg, Marcos Takeo Obara, Roberta Sitnik, Alberto Meyer and Cristóvão Luis Pitangueiras Mangueira
    Citation: BMC Cancer 2019 19:324
    Content type: Case report Published on:

  16. Multiple trials have attempted to assess the diagnostic value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in osteosarcoma with results remaining inconclusive. This ...

    Authors: Fanxiao Liu, Qingyu Zhang, Dongsheng Zhou and Jinlei Dong
    Citation: BMC Cancer 2019 19:323
    Content type: Research article Published on:

  17. MYC is a heterogeneously expressed transcription factor that plays a multifunctional role in many biological processes such as cell proliferation and differentiation. It is also associated with many types of c...

    Authors: Karsten Kleo, Lora Dimitrova, Elisabeth Oker, Nancy Tomaszewski, Erika Berg, Franziska Taruttis, Julia C. Engelmann, Philipp Schwarzfischer, Jörg Reinders, Rainer Spang, Wolfram Gronwald, Peter J. Oefner and Michael Hummel
    Citation: BMC Cancer 2019 19:322
    Content type: Research article Published on:

  18. The purpose of this review is to update previously published reviews on exercise programming in exercise trials in prostate cancer survivors. We evaluated: 1) the application of the principles of exercise trai...

    Authors: Sarah E. Neil-Sztramko, Mary E. Medysky, Kristin L. Campbell, Kelcey A. Bland and Kerri M. Winters-Stone
    Citation: BMC Cancer 2019 19:321
    Content type: Research article Published on:

  19. Oesophageal cancer has a high metastatic potential and poor prognosis, with a significant risk of recurrence after radical resection. However, resected pancreatic metastasis from oesophageal cancer is rare.

    Authors: Wataru Koizumi, Minoru Kitago, Masahiro Shinoda, Hiroshi Yagi, Yuta Abe, Go Oshima, Shutaro Hori, Kenta Inomata, Hirofumi Kawakubo, Miho Kawaida and Yuko Kitagawa
    Citation: BMC Cancer 2019 19:320
    Content type: Case report Published on:

  20. Despite the previously suggested role of Neudesin in tumorigenesis and its potential as a novel target for the treatment of cancers, its prognostic value has never been examined. Thus, the aim of the study was...

    Authors: Olga M. Koper-Lenkiewicz, Joanna Kamińska, Anna Milewska, Karol Sawicki, Marek Jadeszko, Zenon Mariak, Joanna Reszeć, Violetta Dymicka-Piekarska and Joanna Matowicka-Karna
    Citation: BMC Cancer 2019 19:319
    Content type: Research article Published on:

  21. The differentiation between pancreatic head cancer (PHC) and distal cholangiocarcinoma (DCC) can be challenging because of their anatomical and histopathological similarity. This is an important problem, becau...

    Authors: Tsutomu Takenami, Shimpei Maeda, Hideaki Karasawa, Takashi Suzuki, Toru Furukawa, Takanori Morikawa, Tatsuyuki Takadate, Hiroki Hayashi, Kei Nakagawa, Fuyuhiko Motoi, Takeshi Naitoh and Michiaki Unno
    Citation: BMC Cancer 2019 19:318
    Content type: Research article Published on:

  22. In France, a Pap test for cervical cancer screening is recommended every three years for all sexually active women aged 25 to 65 years. Modes of contraception (any or no contraception, with or without a visit to ...

    Authors: Stéphanie Mignot, Virginie Ringa, Solène Vigoureux, Marie Zins, Henri Panjo, Pierre-Jean Saulnier and Xavier Fritel
    Citation: BMC Cancer 2019 19:317
    Content type: Research article Published on:

  23. Regulatory immune cells may modulate the lymphoma microenvironment and are of great interest due to the increasing prevalence of treatment with immunotherapies in lymphoma patients. The aim was to explore the ...

    Authors: R-M Amini, G. Enblad, P. Hollander, S. Laszlo, E. Eriksson, K. Ayoola Gustafsson, A. Loskog and I. Thörn
    Citation: BMC Cancer 2019 19:316
    Content type: Research article Published on:

  24. Different strains of Newcastle disease virus (NDV) worldwide proved to have tumouricidal activity in several types of cancer cells. However, the possible anti-cancer activity of Malaysian NDV AF2240 strain and...

    Authors: Juraimi Raihan, Umar Ahmad, Yoke Keong Yong, Zolkapli Eshak, Fauziah Othman and Aini Ideris
    Citation: BMC Cancer 2019 19:315
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:378

  25. Mean platelet volume (MPV) is a marker of platelet activation. MPV and platelet count (PC) are negatively correlated, and their ratio (MPV/PC) is informative for the diagnosis of malignant tumors. However, the...

    Authors: Yang-Yang Wu, Xuan Zhang, Yuan-Yuan Qin, Jin-Qiu Qin and Fa-Quan Lin
    Citation: BMC Cancer 2019 19:314
    Content type: Research article Published on:

  26. In the majority of familial breast cancer (BC) families, the etiology of the disease remains unresolved. To identify missing BC heritability resulting from relatively rare variants (minor allele frequency ≤ 1%...

    Authors: Rajendra Bahadur Shahi, Sylvia De Brakeleer, Ben Caljon, Ingrid Pauwels, Maryse Bonduelle, Sofie Joris, Christel Fontaine, Marian Vanhoeij, Sonia Van Dooren, Erik Teugels and Jacques De Grève
    Citation: BMC Cancer 2019 19:313
    Content type: Research article Published on:

  27. The tumour microenvironment is a critical regulator of malignant cancer progression. While endothelial cells have been widely studied in the context of tumour angiogenesis, their role as modulators of cancer c...

    Authors: Daniela A. Ferraro, Francesca Patella, Sara Zanivan, Cinzia Donato, Nicola Aceto, Monica Giannotta, Elisabetta Dejana, Maren Diepenbruck, Gerhard Christofori and Martin Buess
    Citation: BMC Cancer 2019 19:312
    Content type: Research article Published on:

  28. Feline injection-site sarcoma (FISS), an aggressive iatrogenic subcutaneous malignancy, is challenging to manage clinically and little is known about the molecular basis of its pathogenesis. Tumor transcriptom...

    Authors: Qi Wei, Stephen A. Ramsey, Maureen K. Larson, Noah E. Berlow, Donasian Ochola, Christopher Shiprack, Amita Kashyap, Bernard Séguin, Charles Keller and Christiane V. Löhr
    Citation: BMC Cancer 2019 19:311
    Content type: Research article Published on:

  29. Colorectal cancer (CRC) is the second cause of tumour mortality in Spain and Europe. To date, no studies have been conducted in Spain to evaluate the spatial and temporal distribution of the excess risk of dea...

    Authors: J. M. García-Torrecillas, M. C. Olvera-Porcel, M. Ferrer-Márquez, F. Rubio-Gil, M J. Sánchez and M. Rodríguez-Barranco
    Citation: BMC Cancer 2019 19:310
    Content type: Research article Published on:

  30. To evaluate the diagnostic value of MR imaging for the differentiation of lipomas and atypical lipomatous tumors (ALT) in comparison with histology and MDM2 amplification status.

    Authors: Carolin Knebel, Jan Neumann, Benedikt J. Schwaiger, Dimitris C. Karampinos, Daniela Pfeiffer, Katja Specht, Ulrich Lenze, Rüdiger von Eisenhart-Rothe, Ernst J. Rummeny, Klaus Woertler and Alexandra S. Gersing
    Citation: BMC Cancer 2019 19:309
    Content type: Research article Published on:

  31. Expression of Nodal, a member of the TGF-β superfamily, is commonly absent in differentiated tissues, while its re-expression occurs in a variety of human malignancy. However, little is known about its involve...

    Authors: Rinako Miura, Ako Yokoi, Toshihide Matsumoto, Yasuko Oguri, Miki Hashimura, Masataka Tochimoto, Sabine Kajita and Makoto Saegusa
    Citation: BMC Cancer 2019 19:308
    Content type: Research article Published on:

  32. The transcription factor hypoxia inducible factor (HIF) -1 drives tumor growth and metastasis and is associated with poor prognosis in breast cancer. Ascorbate can moderate HIF-1 activity in vitro and is assoc...

    Authors: Elizabeth J. Campbell, Gabi U. Dachs, Helen R. Morrin, Valerie C. Davey, Bridget A. Robinson and Margreet C. M. Vissers
    Citation: BMC Cancer 2019 19:307
    Content type: Research article Published on:

  33. Neoadjuvant chemotherapy (NAC) is increasingly used to treat locally advanced breast cancer (LABC). Improved response to NAC correlates with better survival outcomes. The dual purpose of this study is to repor...

    Authors: Jonathan Klein, William Tran, Elyse Watkins, Danny Vesprini, Frances C. Wright, Nicole J. Look Hong, Sonal Ghandi, Alex Kiss and Gregory J. Czarnota
    Citation: BMC Cancer 2019 19:306
    Content type: Research article Published on:

  34. In stage III non-small cell lung cancer (NSCLC) treated with concomitant chemoradiotherapy, there is a high rate of relapse. Some of these relapses are only local and can be treated by stereotactic ablative ra...

    Authors: Shakeel Sumodhee, Pierre-Yves Bondiau, Michel Poudenx, Charlotte Cohen, Arash O. Naghavi, Bernard Padovani, Daniel Maneval, Jocelyn Gal, Axel Leysalle, Hannah Ghalloussi, Josiane Otto and Jérôme Doyen
    Citation: BMC Cancer 2019 19:305
    Content type: Research article Published on:

  35. Adjuvant therapy improves the prognosis of stage II & III colon cancer patients. Unfortunately, most patients do not benefit from this treatment. PePITA (NCT00994864) is a prospective, multicenter, non-randomi...

    Authors: Françoise Rothé, Marion Maetens, Ghizlane Rouas, Marianne Paesmans, Marc Van den Eynde, Jean-Luc Van Laethem, Philippe Vergauwe, Guido Deboever, Yacine Bareche, Caroline Vandeputte, Michail Ignatiadis and Alain Hendlisz
    Citation: BMC Cancer 2019 19:304
    Content type: Research article Published on:

  36. Many factors influence bone metastases of lung cancer, and several studies report about survival of skeletal metastasis. However, few studies have focused on identifying the prognostic factors for skeletal met...

    Authors: Yong Jin Cho, Yung Min Cho, Sung Hyun Kim, Kyoo-Ho Shin, Sung-Taek Jung and Hyo Song Kim
    Citation: BMC Cancer 2019 19:303
    Content type: Research article Published on:

  37. Upregulation of SLC2A genes that encode glucose transporter (GLUT) protein is associated with poor prognosis in many cancers. In colorectal cancer, studies reporting the association between overexpression of GLUT...

    Authors: Eunyoung Kim, Sohee Jung, Won Seo Park, Joon-Hyop Lee, Rumi Shin, Seung Chul Heo, Eun Kyung Choe, Jae Hyun Lee, Kwangsoo Kim and Young Jun Chai
    Citation: BMC Cancer 2019 19:302
    Content type: Research article Published on:

  38. Genetic alterations, including mutation of epidermal growth factor receptor or v-Ki-ras2 kirsten rat sarcoma viral oncogene homolog and fusion of anaplastic lymphoma kinase (ALK), RET proto-oncogene (RET), or v-r...

    Authors: Koh Furugaki, Marie Mochizuki, Mirei Kohno, Sei Shu, Naoki Harada and Yasushi Yoshimura
    Citation: BMC Cancer 2019 19:301
    Content type: Research article Published on:

  39. Solid tumours are less oxygenated than normal tissues. This is called tumour hypoxia and leads to resistance to radiotherapy and chemotherapy. The molecular mechanisms underlying such resistance have been inve...

    Authors: Sophie Cowman, Yuen Ngan Fan, Barry Pizer and Violaine Sée
    Citation: BMC Cancer 2019 19:300
    Content type: Research article Published on:

  40. Most tumor cells show aberrantly activated Akt which leads to increased cell survival and resistance to cancer radiotherapy. Therefore, targeting Akt can be a promising strategy for radiosensitization. Here, w...

    Authors: Cholpon S. Djuzenova, Vanessa Fiedler, Simon Memmel, Astrid Katzer, Dmitri Sisario, Philippa K. Brosch, Alexander Göhrung, Svenja Frister, Heiko Zimmermann, Michael Flentje and Vladimir L. Sukhorukov
    Citation: BMC Cancer 2019 19:299
    Content type: Research article Published on:

  41. We reported previously the usefulness of 18F-2-fluoro-2-deoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) to predict prognosis of renal cell carcinoma (RCC) treated with molecular targ...

    Authors: Tadashi Tabei, Noboru Nakaigawa, Tomohiro Kaneta, Ichiro Ikeda, Keiichi Kondo, Kazuhide Makiyama, Hisashi Hasumi, Narihiko Hayashi, Takashi Kawahara, Koji Izumi, Kimito Osaka, Kentaro Muraoka, Jun-ichi Teranishi, Yasuhide Miyoshi, Yasushi Yumura, Hiroji Uemura…
    Citation: BMC Cancer 2019 19:298
    Content type: Research article Published on:

  42. Papillary thyroid cancer (PTC) is the most frequent type of thyroid malignancy. In this study, we investigated the mechanisms whereby long non-coding RNAs (lncRNAs) are associated with PTC pathogenesis.

    Authors: Bin Song, Rurun Li, Zhihua Zuo, Juan Tan, Ling Liu, Dafa Ding, Yibing Lu and Dawei Hou
    Citation: BMC Cancer 2019 19:297
    Content type: Research article Published on:

  43. High-grade serous ovarian cancer is a detrimental disease. Treatment options in patients with a recurrent disease are dependent on BRCA1/2 mutation status since only patients with known BRCA mutation are eligible...

    Authors: Andreja Gornjec, Srdjan Novakovic, Vida Stegel, Marko Hocevar, Ziva Pohar Marinsek, Barbara Gazic, Mateja Krajc and Erik Skof
    Citation: BMC Cancer 2019 19:296
    Content type: Research article Published on:

  44. Early gastric cancer is associated with a much better prognosis than advanced disease, and strategies to improve prognosis is strictly dependent on earlier detection and accurate diagnosis. Therefore, a label-...

    Authors: Lianhuang Li, Deyong Kang, Zicheng Huang, Zhenlin Zhan, Changyin Feng, Yongjian Zhou, Haohua Tu, Shuangmu Zhuo and Jianxin Chen
    Citation: BMC Cancer 2019 19:295
    Content type: Research article Published on:

  45. Thyroid cancer is the most frequent endocrine neoplasia worldwide. Information from Andean countries is scarce. In Ecuador there is no reports available of the epidemiology of this type of cancer. The aim of t...

    Authors: Jorge Salazar-Vega, Esteban Ortiz-Prado, Paola Solis-Pazmino, Lenin Gómez-Barreno, Katherine Simbaña-Rivera, Aquiles R. Henriquez-Trujillo, Juan P. Brito, Theofilos Toulkeridis and Marco Coral-Almeida
    Citation: BMC Cancer 2019 19:294
    Content type: Research article Published on:

  47. Triple Negative breast cancer (TNBC) is a poor outcome subgroup of breast cancer defined based on the absence of expression of ERα and PR and HER2 amplification. These hard to treat cancers lack targeted treat...

    Authors: Paul B. Mullan, Victoria Bingham, Paula Haddock, Gareth W. Irwin, Elaine Kay, Stephen McQuaid and Niamh E. Buckley
    Citation: BMC Cancer 2019 19:236
    Content type: Research article Published on:

  48. Although sorafenib is the global standard first-line systemic treatment for unresectable hepatocellular carcinoma (HCC), it does not have reliable predictive or prognostic biomarkers. Circulating cell-free DNA...

    Authors: Chung Ryul Oh, Sun-Young Kong, Hyeon-Su Im, Hwa Jung Kim, Min Kyeong Kim, Kyong-Ah Yoon, Eun-Hae Cho, Ja-Hyun Jang, Junnam Lee, Jihoon Kang, Sook Ryun Park and Baek-Yeol Ryoo
    Citation: BMC Cancer 2019 19:292
    Content type: Research article Published on:

  49. The treatment paradigm for metastatic hormone-sensitive prostate cancer (mHSPC) patients is evolving. PET/CT now offers improved sensitivity and accuracy in staging. Recent randomized trial data supports escal...

    Authors: Neil R. Parikh, Claudia Huiza, Jill S. Patel, Sonny Tsai, Nathisha Kalpage, May Thein, Sage Pitcher, Steve P. Lee, Warren S. Inouye, Mark L. Jordan, Homayoon Sanati, Lida Jafari, Carol J. Bennett, Greg E. Gin, Amar U. Kishan, Robert E. Reiter…
    Citation: BMC Cancer 2019 19:291
    Content type: Study protocol Published on:

  50. Human papillomavirus (HPV) vaccines are indicated for the prevention of cancers and genital warts caused by vaccine-covered HPV types. Although the standard regimen requires a two or three-dose vaccine series,...

    Authors: Yi Zeng, Anna-Barbara Moscicki, Vikrant V. Sahasrabuddhe, Francisco Garcia, Heide Woo, Chiu-Hsieh Hsu, Eva Szabo, Eileen Dimond, Susan Vanzzini, Angelica Mondragon, Valerie Butler, Hillary DeRose and H.-H. Sherry Chow
    Citation: BMC Cancer 2019 19:290
    Content type: Study protocol Published on:

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