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  1. A review of therapies for advanced cancers licenced by the EMA between 2009 and 2013 concluded that for more than half of these drugs there was little evidence of overall survival or quality of life benefit. R...

    Authors: Martin Connock, Xavier Armoiry, Alexander Tsertsvadze, G. J. Melendez-Torres, Pamela Royle, Lazaros Andronis and Aileen Clarke
    Citation: BMC Cancer 2019 19:392
    Content type: Research article Published on:

  2. Upfront cytoreductive surgery with HIPEC (CRS-HIPEC) is the standard treatment for isolated resectable colorectal peritoneal metastases (PM) in the Netherlands. This study investigates whether addition of peri...

    Authors: Koen P. Rovers, Checca Bakkers, Geert A. A. M. Simkens, Jacobus W. A. Burger, Simon W. Nienhuijs, Geert-Jan M. Creemers, Anna M. J. Thijs, Alexandra R. M. Brandt-Kerkhof, Eva V. E. Madsen, Ninos Ayez, Nadine L. de Boer, Esther van Meerten, Jurriaan B. Tuynman, Miranda Kusters, Nina R. Sluiter, Henk M. W. Verheul…
    Citation: BMC Cancer 2019 19:390
    Content type: Study protocol Published on:

  3. The impact of Tet oncogene family member 2 (TET2) mutations on the prognosis of acute myeloid leukemia (AML) is still controversial. A meta analysis is needed in order to assess the prognostic significance of TET...

    Authors: Ruiqi Wang, Xiaoning Gao and Li Yu
    Citation: BMC Cancer 2019 19:389
    Content type: Research article Published on:

  4. Effector CD8+ T cell activation and its cytotoxic function to eradicate tumor cells depend on the T cell recognition of tumor neoantigens, and are positively associated with improved survival in breast cancer. Tu...

    Authors: Lingeng Lu, Huatian Huang, Jing Zhou, Wenxue Ma, Sean Mackay and Zuoheng Wang
    Citation: BMC Cancer 2019 19:387
    Content type: Research article Published on:

  5. Previous neurocognitive assessments in non-central nervous system cancers highlight the high incidence of neurocognitive dysfunction in this study population. However, there have been few studies exploring neu...

    Authors: Yingchun Zeng, Andy S. K. Cheng, Ting Song, Xiujie Sheng, Huaidong Cheng, Yingwei Qiu, Jianfei Xie and Chetwyn C. H. Chan
    Citation: BMC Cancer 2019 19:386
    Content type: Research article Published on:

  6. Little is known about the pathway to diagnosis of lymphoma in Sub-Saharan Africa, despite the increased risk of lymphoma in people living with HIV (PLHIV). The challenges of diagnosis in this setting include d...

    Authors: Katherine Antel, Carly Levetan, Zainab Mohamed, Vernon J Louw, Jenna Oosthuizen, Gary Maartens and Estelle Verburgh
    Citation: BMC Cancer 2019 19:384
    Content type: Research article Published on:

  7. Salinomycin is a monocarboxylic polyether antibiotic and is a potential chemotherapy drug. Our previous studies showed that salinomycin inhibited cell growth and targeted CSCs in prostate cancer. However, the ...

    Authors: Yunsheng Zhang, Fang Li, Luogen Liu, Hongtao Jiang, Hua Hu, Xiaobo Du, Xin Ge, Jingsong Cao and Yi Wang
    Citation: BMC Cancer 2019 19:381
    Content type: Research article Published on:

  8. The healthcare system (HCS) improved in Tibet Autonomous Region (TAR), China. The present study aimed to investigate whether these improvements might alter the clinicopathological characteristics of a Tibetan ...

    Authors: Yulan Zhao, Hanhuan Luo, Xintian Zhang, Tashi Bianba, Lin Li, Qian Wang, Lei Guo, Dian Wang, Yongge Ze and Shan Zheng
    Citation: BMC Cancer 2019 19:380
    Content type: Research article Published on:

  11. Smoking is one of the well-established risk factors for gastric cancer incidence, yet whether men are more or equally susceptible to gastric cancer due to smoking compared with women is a matter of controversy...

    Authors: Wen-Ya Li, Yunan Han, Hui-Mian Xu, Zhen-Ning Wang, Ying-Ying Xu, Yong-Xi Song, Hao Xu, Song-Cheng Yin, Xing-Yu Liu and Zhi-Feng Miao
    Citation: BMC Cancer 2019 19:377
    Content type: Research article Published on:

  12. Previous work in our laboratory demonstrated that antiprogestin mifepristone impairs the growth and adhesion of highly metastatic cancer cells, and causes changes in their cellular morphology. In this study, w...

    Authors: Sabrina J. Ritch, BreeAnn N. Brandhagen, Alicia A. Goyeneche and Carlos M. Telleria
    Citation: BMC Cancer 2019 19:376
    Content type: Technical advance Published on:

  13. Most endocervical adenocarcinomas are human papillomavirus (HPV)-related cancers associated with p16 immunostaining. Ovarian metastasis from cervical cancer is a rare phenomenon, the mechanism of dissemination...

    Authors: Alexandra Arfi, Delphine Hequet, Guillaume Bataillon, Carine Tran-Perennou, Fereshteh Farkhondeh, Xavier Sastre-Garau, Virginie Fourchotte, Roman Rouzier, Enora Laas, Nicolas Pouget, Anne Vincent-Salomon and Emmanuelle Jeannot
    Citation: BMC Cancer 2019 19:375
    Content type: Case report Published on:

  15. There is a paucity of plasma-based biomarkers that prospectively segregate the outcome of patients with head and neck squamous-cell carcinoma (HNSCC) treated with chemoradiation therapy (CRT). Plasma extracell...

    Authors: Dorival Mendes Rodrigues-Junior, Soon Sim Tan, Luciano de Souza Viana, Andre Lopes Carvalho, Sai Kiang Lim, N Gopalakrishna Iyer and Andre Luiz Vettore
    Citation: BMC Cancer 2019 19:373
    Content type: Research article Published on:

  16. As the efficacy of radiotherapy and chemotherapy for treatment of phyllodes tumors (PTs) remains unclear, this study aimed to review all available data and evaluate the roles of radiotherapy and chemotherapy i...

    Authors: Xue Chao, Kai Chen, Jiayi Zeng, Zhuofei Bi, Mingyan Guo, Yi Chen, Yandan Yao, Wei Wu, Shi Liang and Yan Nie
    Citation: BMC Cancer 2019 19:372
    Content type: Research article Published on:

  17. Many breast cancer survivors (BCS) report deficits in cognitive function. Physical activity (PA) has been associated with better processing speed and memory in healthy adults and thus may be a useful method fo...

    Authors: Elizabeth A. Salerno, Kendrith Rowland, Arthur F. Kramer and Edward McAuley
    Citation: BMC Cancer 2019 19:371
    Content type: Research article Published on:

  18. Most methods that integrate network and mutation data to study cancer focus on the effects of genes/proteins, quantifying the effect of mutations or differential expression of a gene and its neighbors, or iden...

    Authors: Matthew Ruffalo and Ziv Bar-Joseph
    Citation: BMC Cancer 2019 19:370
    Content type: Technical Advance Published on:

  19. Intratumoral epidermal growth factor receptor (EGFR) mutational heterogeneity is yet controversial in non-small cell lung cancer (NSCLC) patients. Single-cell analysis provides the genetic profile of single cance...

    Authors: Longhua Guo, Zhihong Chen, Chongrui Xu, Xuchao Zhang, Honghong Yan, Jian Su, Jinji Yang, Zhi Xie, Weibang Guo, Feng Li, Yilong Wu and Qing Zhou
    Citation: BMC Cancer 2019 19:369
    Content type: Research article Published on:

  20. Alternative models of cancer follow-up care are needed to ameliorate pressure on services and better meet survivors’ long-term needs. This paper reports an evaluation of a service improvement initiative for th...

    Authors: Jane Frankland, Hazel Brodie, Deborah Cooke, Claire Foster, Rebecca Foster, Heather Gage, Jake Jordan, Ines Mesa-Eguiagaray, Ruth Pickering and Alison Richardson
    Citation: BMC Cancer 2019 19:368
    Content type: Research article Published on:

  21. Cervical Cancer is still a major public health challenge in low and middle-income countries. HPV testing has been an innovative approach, which was introduced in Argentina for women aged 30+ through the Jujuy ...

    Authors: Juan Gago, Melisa Paolino and Silvina Arrossi
    Citation: BMC Cancer 2019 19:367
    Content type: Research article Published on:

  22. Following publication of the original article [1], it was reported that the legend for Fig. 1 was incomplete. The complete figure legend is:

    Authors: Aleksandar Sekulic, Michael R. Migden, Nicole Basset-Seguin, Claus Garbe, Anja Gesierich, Christopher D. Lao, Chris Miller, Laurent Mortier, Dedee F. Murrell, Omid Hamid, Jorge F. Quevedo, Jeannie Hou, Edward McKenna, Natalie Dimier, Sarah Williams, Dirk Schadendorf…
    Citation: BMC Cancer 2019 19:366
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2017 17:332

  23. Worldwide, breast cancer is the main cause of cancer mortality in women. Most cases originate in mammary ductal cells that produce the nipple aspirate fluid (NAF). In cancer patients, this secretome contains p...

    Authors: Giselle Villa Flor Brunoro, Paulo Costa Carvalho, Valmir C. Barbosa, Dante Pagnoncelli, Claudia Vitória De Moura Gallo, Jonas Perales, René Peiman Zahedi, Richard Hemmi Valente and Ana Gisele da Costa Neves-Ferreira
    Citation: BMC Cancer 2019 19:365
    Content type: Research article Published on:

  24. Our aim of the study is to investigate the feasibility of preoperative prediction for hepatocellular carcinoma (HCC) histological grading using gadoxetic acid-enhanced magnetic resonance imaging (MRI).

    Authors: Kun Huang, Zhi Dong, Huasong Cai, Mengqi Huang, Zhenpeng Peng, Ling Xu, Yingmei Jia, Chenyu Song, Zi-Ping Li and Shi-Ting Feng
    Citation: BMC Cancer 2019 19:364
    Content type: Research article Published on:

  25. Hepatoma arterial-embolization prognostic (HAP) score and its modifications (modified HAP [mHAP] and mHAP-II), consisting of some or all of the following factors of tumor size, number, alpha-fetoprotein, bilir...

    Authors: Yehyun Park, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han, Jong Eun Yeon, Kwan Soo Byun, Hye Soo Kim, Ji Hoon Kim and Seung Up Kim
    Citation: BMC Cancer 2019 19:363
    Content type: Research article Published on:

  27. Phase I trials aim to identify the recommended dose for further development. Health-related quality of life (HRQoL) could be a complement to the usual National Cancer Institute Common Terminology Criteria for ...

    Authors: Frédéric Fiteni, Isabelle Le Ray, Ahmad Ousmen, Nicolas Isambert, Amélie Anota and Franck Bonnetain
    Citation: BMC Cancer 2019 19:361
    Content type: Research article Published on:

  28. In clinical practice, the detection of biomarkers is mostly based on primary tumors for its convenience in acquisition. However, immune checkpoints may express differently between primary and metastatic tumor....

    Authors: Xingming Zhang, Xiaoxue Yin, Haoran Zhang, Guangxi Sun, Yaojing Yang, Junru Chen, Xudong Zhu, Peng Zhao, Jinge Zhao, Jiandong Liu, Ni Chen, Jia Wang, Pengfei Shen and Hao Zeng
    Citation: BMC Cancer 2019 19:360
    Content type: Research article Published on:

  30. Micafungin is a well-tolerated and effective prophylactic antifungal agent used in hematologic diseases. In this prospective trial, we evaluated the efficacy and safety of prophylactic micafungin during first ...

    Authors: Hyunkyung Park, Jeonghwan Youk, Dong-Yeop Shin, Junshik Hong, Inho Kim, Nam Joong Kim, Jeong-Ok Lee, Soo-Mee Bang, Sung-Soo Yoon, Wan Beom Park and Youngil Koh
    Citation: BMC Cancer 2019 19:358
    Content type: Research article Published on:

  31. Osteosarcoma is the most common malignant bone tumor in children. Survival remains poor among histologically poor responders, and there is a need to identify them at diagnosis to avoid delivering ineffective t...

    Authors: Krithika Bhuvaneshwar, Michael Harris, Yuriy Gusev, Subha Madhavan, Ramaswamy Iyer, Thierry Vilboux, John Deeken, Elizabeth Yang and Sadhna Shankar
    Citation: BMC Cancer 2019 19:357
    Content type: Research article Published on:

  32. Glucocorticoid receptor (GR) activation has been associated with breast cancer cell survival in vitro. Glucocorticoid (GC)-dependent protection against tumor necrosis factor (TNF)-induced cell death has been w...

    Authors: Irma B. Mitre-Aguilar, Tonatiuh Barrios-Garcia, Victor M. Ruiz-Lopez, Alberto J. Cabrera-Quintero, Nancy R. Mejia-Dominguez, Jose L. Ventura-Gallegos, Daniel Moreno-Mitre, Alejandro Aranda-Gutierrez, Janini Mejia-Rangel, Alma R. Escalona-Guzman, Yanin Chavarri-Guerra, Alfonso Leon-Del-Rio and Alejandro Zentella-Dehesa
    Citation: BMC Cancer 2019 19:356
    Content type: Research article Published on:

  33. Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) that often affects men over the age of 60. Systemic metastasis of MCL to eyes is rare and intraocular involvement is even rare...

    Authors: Minghang Pei, Chan Zhao, Fei Gao and Meifen Zhang
    Citation: BMC Cancer 2019 19:355
    Content type: Case report Published on:

  34. Head and neck squamous cell carcinoma (HNSCC) represents one of the most common malignancies worldwide with a high mortality rate mainly due to lack of early detection markers, frequent association with metast...

    Authors: Subhayan Sur, Hiroshi Nakanishi, Robert Steele and Ratna B. Ray
    Citation: BMC Cancer 2019 19:354
    Content type: Research article Published on:

  35. Locally advanced or metastatic non-small cell lung cancer (NSCLC) that has progressed after first-line treatment has a poor prognosis. Recent randomized clinical trials (RCTs) have demonstrated survival benefi...

    Authors: Adrian D. Vickers, Katherine B. Winfree, Gebra Cuyun Carter, Urpo Kiiskinen, Min-Hua Jen, Donald Stull, James A. Kaye and David P. Carbone
    Citation: BMC Cancer 2019 19:353
    Content type: Research article Published on:

  36. High risk human papillomaviruses (HPV) plays important roles in the development of cervical cancer, a number of other anogenital cancer and they are increasingly found in oropharyngeal squamous cell carcinoma ...

    Authors: Ge Gao, Jintu Wang, Jan L. Kasperbauer, Nicole M. Tombers, Fei Teng, Honglan Gou, Yonggang Zhao, Zhenhong Bao and David I. Smith
    Citation: BMC Cancer 2019 19:352
    Content type: Research article Published on:

  37. Optimising breast cancer treatment remains a challenge. Resistance to therapy is a major problem in both ER- and ER+ breast cancer. Tumour recurrence after chemotherapy and/or targeted therapy leads to more ag...

    Authors: Lana McClements, Stephanie Annett, Anita Yakkundi, Martin O’Rourke, Andrea Valentine, Nermeen Moustafa, Abdelrahim Alqudah, Bruno M. Simões, Fiona Furlong, Amy Short, Stuart A. McIntosh, Helen O. McCarthy, Robert B. Clarke and Tracy Robson
    Citation: BMC Cancer 2019 19:351
    Content type: Research article Published on:

  38. Salivary gland carcinoma ranks the sixth in head and neck cancers while it is relatively rare in its incidence. Epidemiological studies have been based mostly on institutional data, leading to selection bias i...

    Authors: Jin-Ye Fu, Chun-Xiao Wu, Shu-Kun Shen, Ying Zheng, Chen-Ping Zhang and Zhi-Yuan Zhang
    Citation: BMC Cancer 2019 19:350
    Content type: Research article Published on:

  39. The exact signalling mechanism of the mTOR complex remains a subject of constant debate, even with some evidence that amino acids participate in the same pathway as used for insulin signalling during protein s...

    Authors: Bread Cruz, André Oliveira, Gislaine Ventrucci and Maria Cristina Cintra Gomes-Marcondes
    Citation: BMC Cancer 2019 19:349
    Content type: Research article Published on:

  40. Extrahepatic cholangiocarcinoma (ECC) has become one of the most rapidly increasing malignancies in China during recent decades. The relationship between tobacco exposure and ECC epidemics is unclear; this stu...

    Authors: Lei Hou, Jingmei Jiang, Boqi Liu, Wei Han, Yanping Wu, Xiaonong Zou, Fang Xue, Yuanli Chen, Biao Zhang, Haiyu Pang, Yuyan Wang, Zixing Wang, Yaoda Hu and Junyao Li
    Citation: BMC Cancer 2019 19:348
    Content type: Research article Published on:

  41. Hematopoietic stem cell transplantation (HSCT) remains an important therapeutic option for many hematologic malignancies. Bone marrow harvesting from an appropriate donor must be conducted for hematopoietic st...

    Authors: Tae-Woo Nam, Hyun-Min Oh, Jae-Eun Lee, Ju-Hyun Kim, Jong-moon Hwang, Eunhee Park and Tae-Du Jung
    Citation: BMC Cancer 2019 19:347
    Content type: Case report Published on:

  42. Prostate cancer is the most common form of cancer in males and accounts for high cancer related deaths. Therapeutic advancement in prostate cancer has not been able to reduce the mortality burden of prostate c...

    Authors: Ankit Tiwari, Bratati Mukherjee, Md. Khurshidul Hassan, Niharika Pattanaik, Archita Mohanty Jaiswal and Manjusha Dixit
    Citation: BMC Cancer 2019 19:346
    Content type: Research article Published on:

  43. Background: Benign breast lesions are the most common diseases in adult women, which have been treated with minimally invasive therapies in recent years. Little is known about the feasibility of Microwave abla...

    Authors: Wei Zhang, Zhan-Qiang Jin, Masoud Baikpour, Jian-Min Li, Hui Zhang, Ting Liang, Xiao-Ming Pan and Wen He
    Citation: BMC Cancer 2019 19:345
    Content type: Research article Published on:

  44. This study protocol describes the clinical trial of the Fex-Can intervention, a web-based self-help program targeting sexual dysfunction and fertility-related distress. The psycho-educational intervention has ...

    Authors: C. Lampic, L. Ljungman, C. Micaux Obol, L. E. Eriksson and L. Wettergren
    Citation: BMC Cancer 2019 19:344
    Content type: Study protocol Published on:

  45. Hepatocellular carcinoma (HCC) is a leading cause of cancer related deaths worldwide. The PI3K cascade is one of the major signaling pathways underlying HCC development and progression. Activating mutations of...

    Authors: Hui Cao, Zhong Xu, Jingxiao Wang, Antonio Cigliano, Maria G. Pilo, Silvia Ribback, Shu Zhang, Yu Qiao, Li Che, Rosa M. Pascale, Diego F. Calvisi and Xin Chen
    Citation: BMC Cancer 2019 19:343
    Content type: Research article Published on:

  46. The surgical treatment of breast cancer has been associated with negative consequences for patients’ body image, sexual functioning, mental health, and social adjustment. Recent advances in the surgical approa...

    Authors: Jennifer Gass, Sunny Mitchell and Michael Hanna
    Citation: BMC Cancer 2019 19:342
    Content type: Research article Published on:

  47. Outcomes of patients with ovarian high-grade serous carcinoma (HGSC) treated with neoadjuvant chemotherapy (NAC) have been widely studied, but there is limited information on the outcomes of patients with non-...

    Authors: Young Shin Chung, Sang-Yoon Park, Jung-Yun Lee, Jeong-Yeol Park, Jeong-Won Lee, Hee Seung Kim, Dong Soo Suh, Yun Hwan Kim, Jong-Min Lee, Miseon Kim, Min Chul Choi, Seung-Hyuk Shim, Keun Ho Lee, Taejong Song, Jin Hwa Hong, Won Moo Lee…
    Citation: BMC Cancer 2019 19:341
    Content type: Research article Published on:

  48. Breast, colorectal, and prostate cancer survivors are at increased risk for late and long-term effects post-treatment. The post-treatment phase of care is often poorly coordinated and survivors navigate follow...

    Authors: Stacy N. Davis, Denalee M. O’Malley, Alicja Bator, Pamela Ohman-Strickland, Lynn Clemow, Jeanne M. Ferrante, Benjamin F. Crabtree, Suzanne M. Miller, Patricia Findley and Shawna V. Hudson
    Citation: BMC Cancer 2019 19:340
    Content type: Study protocol Published on:

  49. Enzalutamide is an oral androgen receptor targeted agent that has been shown to improve survival in PREVAIL trials and has been approved for patients with chemo-naïve metastatic castration-resistant prostate c...

    Authors: Taro Iguchi, Satoshi Tamada, Minoru Kato, Sayaka Yasuda, Takeshi Yamasaki and Tatsuya Nakatani
    Citation: BMC Cancer 2019 19:339
    Content type: Study protocol Published on:

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