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  1. Sunitinib and pazopanib are extensively used as first-line treatment of metastatic renal cell carcinoma (mRCC). We performed this meta-analysis to assess the anti-tumor effectiveness, toxicity, and total costs...

    Authors: Huan Deng, Yu Huang, Zhengdong Hong, Xuhui Yuan, Zhi Cao, Yiping Wei and Wenxiong Zhang
    Citation: BMC Cancer 2019 19:489
    Content type: Research article Published on:

  2. Testosterone suppression is the standard treatment for advanced prostate cancer, and it is associated with side-effects that impair patients’ quality of life, like sexual dysfunction, osteoporosis, weight gain...

    Authors: Gustavo Werutsky, Fernando Cotait Maluf, Eduardo Henrique Cronemberger, Vinicius Carrera Souza, Suelen Patricia dos Santos Martins, Fábio Peixoto, Oren Smaletz, Fábio Schutz, Daniel Herchenhorn, Telma Santos, Flavio Mavignier Carcano, David Queiroz Muniz, Paulo R. S. Nunes Filho, Facundo Zaffaroni, Carlos Barrios and André Fay
    Citation: BMC Cancer 2019 19:487
    Content type: Study protocol Published on:

  4. Metastases account for 90% of all cancer-related deaths, becoming a therapeutic problem. Approximately 50% of all uveal melanoma (UM) patients will develop metastases, mainly in the liver. Post-mortem analyses of...

    Authors: Nyasia M. Jones, Hua Yang, Qing Zhang, Vanessa M. Morales-Tirado and Hans E. Grossniklaus
    Citation: BMC Cancer 2019 19:484
    Content type: Research article Published on:

  5. The relationship between polymorphisms in vascular endothelial growth factor (VEGF) and gastric cancer is still inconclusive. We investigated whether there is an association between VEGF genetic polymorphisms ...

    Authors: Yeon-Ji Kim, Woo Chul/ Chung, Kyong-Hwa Jun and Hyung-Min Chin
    Citation: BMC Cancer 2019 19:483
    Content type: Research article Published on:

  6. We compared the survival outcomes and acute toxicities of weekly and triweekly cisplatin regimens during concurrent chemoradiotherapy (CCRT) in nasopharyngeal carcinoma (NPC) patients.

    Authors: Kailin Wang, Jun Dong, Shasha He, Xia Wang, Chang Jiang, Pili Hu, Jiangui Guo, Xiuyu Cai and Xicheng Wang
    Citation: BMC Cancer 2019 19:482
    Content type: Research article Published on:

  7. Laparoscopic-assisted pylorus-preserving gastrectomy (LAPPG) is a minimally invasive function-preserving surgery for early gastric cancer. This study was designed to investigate the clinical outcomes between L...

    Authors: Xiang Xia, Jia Xu, Chunchao Zhu, Hui Cao, Fengrong Yu and Gang Zhao
    Citation: BMC Cancer 2019 19:481
    Content type: Research article Published on:

  8. Recent studies have extensively investigated the role of miRNAs in colorectal cancer (CRC), and several associations have been reported. In addition, single nucleotide polymorphisms (SNPs) in promoter regions ...

    Authors: Eun-Gyo Kim, Jung Oh Kim, Han Sung Park, Chang Soo Ryu, Jisu Oh, Hak Hoon Jun, Jong Woo Kim and Nam Keun Kim
    Citation: BMC Cancer 2019 19:480
    Content type: Research article Published on:

  9. Vitronectin is a multifunctional glycoprotein known in several human tumors for its adhesive role in processes such as cell growth, angiogenesis and metastasis. In this study, we examined vitronectin expressio...

    Authors: Rebeca Burgos-Panadero, Inmaculada Noguera, Adela Cañete, Samuel Navarro and Rosa Noguera
    Citation: BMC Cancer 2019 19:479
    Content type: Research article Published on:

  10. There were few reports of postoperative radiotherapy (PORT) in stage pIII-N2 Non-small-cell Lung Cancer (NSCLC) patients receiving pneumonectomy followed by adjuvant chemotherapy. This study aims to evaluate s...

    Authors: Wenhui Wang, Yu Men, Jianyang Wang, Zongmei Zhou, Dongfu Chen, Zefen Xiao, Qinfu Feng, Jima Lv, Jun Liang, Nan Bi, Shugeng Gao, Luhua Wang and Zhouguang Hui
    Citation: BMC Cancer 2019 19:478
    Content type: Research article Published on:

  11. Previous studies examining the relationship between hepatitis B virus (HBV) infection and non-Hodgkin lymphoma (NHL) show inconsistent results in different endemic areas. Furthermore, studies evaluating the as...

    Authors: Xi Zhou, Huaxiong Pan, Peng Yang, Pian Ye, Haiyan Cao and Hao Zhou
    Citation: BMC Cancer 2019 19:477
    Content type: Research article Published on:

  14. Radiation therapy is a standard form of treating non-small cell lung cancer, however, local recurrence is a major issue with this type of treatment. A better understanding of the metabolic response to radiatio...

    Authors: Samantha J. Van Nest, Leah M. Nicholson, Nils Pavey, Mathew N. Hindi, Alexandre G. Brolo, Andrew Jirasek and Julian J. Lum
    Citation: BMC Cancer 2019 19:474
    Content type: Research article Published on:

  15. There are limited effective drugs that can reach the brain to target brain tumors, in particular glioblastoma, which is one of the most difficult cancers to be cured from. Because the overexpression of the sig...

    Authors: Chia-Chi Liu, Ching-Fang Yu, Shu-Chi Wang, Hsueh-Yin Li, Chiu-Min Lin, Hsia-Han Wang, Carmen Abate and Chi-Shiun Chiang
    Citation: BMC Cancer 2019 19:473
    Content type: Research article Published on:

  16. Breast cancer (BC) is the most common type of cancer in women worldwide. Post-treatment, patients suffer from side effects and have various rehabilitation needs, which means that individualization is fundament...

    Authors: U. Olsson Möller, I. Beck, L. Rydén and M. Malmström
    Citation: BMC Cancer 2019 19:472
    Content type: Research article Published on:

  17. Transformation of chronic lymphocytic leukaemia (CLL) to diffuse large B-cell lymphoma (DLCBL) type Richter’s syndrome (RS) carries a dismal prognosis. Standard-of-care chemoimmunotherapy for de novo RS is ina...

    Authors: Niamh Appleby, Toby A. Eyre, Maite Cabes, Aimee Jackson, Rebecca Boucher, Francesca Yates, Sonia Fox, Andrew Rawstron, Peter Hillmen and Anna Schuh
    Citation: BMC Cancer 2019 19:471
    Content type: Study protocol Published on:

  18. To explore prognostic value of the pre-treatment primary lesion apparent diffusion coefficient (ADC) in locoregionally advanced nasopharyngeal carcinoma (LA-NPC).

    Authors: Tao-xiang Huang, Nian Lu, Shan-shan Lian, Hui Li, Shao-han Yin, Zhi-jun Geng and Chuan-miao Xie
    Citation: BMC Cancer 2019 19:470
    Content type: Research article Published on:

  19. Breast cancer screening mammography is widespread in industrialised countries within the framework of public health program or opportunist form. Only few data exist on the comparison of effectiveness between o...

    Authors: Sarah Peisl, Stefan Zimmermann, Bertrand Camey, Daniel Betticher and Christine Bouchardy
    Citation: BMC Cancer 2019 19:469
    Content type: Research article Published on:

  20. Only a few patients with pancreatic ductal adenocarcinoma (PDAC) recurring after curative resection and peri-operative (neoadjuvant and adjuvant) therapy are included in clinical trials of metastatic PDAC. As ...

    Authors: Olumide B. Gbolahan, Yan Tong, Amikar Sehdev, Bert O’Neil and Safi Shahda
    Citation: BMC Cancer 2019 19:468
    Content type: Research article Published on:

  21. The optimal surgical margins assessment is capital in oral squamous cell carcinoma (OSCC) management. We evaluated the clinical benefits of integrating intraoperative macroscopic margin (MM) assessment and nar...

    Authors: Alessandro Baj, Nicola Fusco, Alessandro Bolzoni, Daniela Carioli, Camilla Mazzucato, Alice Faversani, Lorenzo Bresciani, Marco Maggioni and Pasquale Capaccio
    Citation: BMC Cancer 2019 19:467
    Content type: Research article Published on:

  22. The prevalence and factors associated with major depressive disorder (MDD) among adults with cancer have been documented in the scientific literature. However, this data is limited among children and adolescen...

    Authors: Benedict Akimana, Catherine Abbo, Joyce Balagadde-Kambugu and Etheldreda Nakimuli-Mpungu
    Citation: BMC Cancer 2019 19:466
    Content type: Research article Published on:

  23. Gene variants are dependable and sensitive biomarkers for target-specific therapies in breast cancer (BC). However, detection of mutations within tissues has many limitations. Plasma circulating free DNA (cfDN...

    Authors: Xin Yang, Kuo Zhang, Caiji Zhang, Rongxue Peng and Chengming Sun
    Citation: BMC Cancer 2019 19:465
    Content type: Research article Published on:

  24. To explore imaging biomarkers that can be used for diagnosis and prediction of pathologic stage in non-small cell lung cancer (NSCLC) using multiple machine learning algorithms based on CT image feature analysis.

    Authors: Lingming Yu, Guangyu Tao, Lei Zhu, Gang Wang, Ziming Li, Jianding Ye and Qunhui Chen
    Citation: BMC Cancer 2019 19:464
    Content type: Research article Published on:

  25. Patients undergoing major cancer surgery frequently require post-acute care for complications and adverse effects. Enhanced recovery after surgery programmes mean that patients are increasingly discharged home...

    Authors: Kerry N. L. Avery, Hollie S. Richards, Amanda Portal, Trudy Reed, Ruth Harding, Robert Carter, Leon Bamforth, Kate Absolom, Elaine O’Connell Francischetto, Galina Velikova and Jane M. Blazeby
    Citation: BMC Cancer 2019 19:463
    Content type: Research article Published on:

  26. Blended cognitive behaviour therapy (bCBT) is an effective treatment for fear of cancer recurrence (FCR) in curatively-treated breast, colorectal and prostate cancer survivors with high FCR. However, long-term...

    Authors: Rens Burm, Belinda Thewes, Laura Rodwell, Wietske Kievit, Anne Speckens, Marieke van de Wal and Judith Prins
    Citation: BMC Cancer 2019 19:462
    Content type: Research article Published on:

  27. We investigated the risk of thyroid disorders, namely hypothyroidism, thyrotoxicosis and thyroiditis, in head and neck cancer patients undergoing multimodal treatment.

    Authors: Chien-Liang Lin, Shang-Yin Wu, Wen-Tsung Huang, Yin-Hsun Feng, Ching-Yi Yiu, Wei-Fan Chiang, Sheng-Yow Ho and Sheng-Hsiang Lin
    Citation: BMC Cancer 2019 19:461
    Content type: Research article Published on:

  28. Preclinical studies suggest synergistic effectiveness of ascorbic acid (AA, vitamin C) and cytotoxic agents in gastrointestinal malignancies. This phase 1 study aimed to establish the maximum tolerated dose (M...

    Authors: Feng Wang, Ming-Ming He, Zi-Xian Wang, Su Li, Ying Jin, Chao Ren, Si-Mei Shi, Bing-Tian Bi, Shuang-Zhen Chen, Zhi-Da Lv, Jia-Jia Hu, Zhi-Qiang Wang, Feng-Hua Wang, De-Shen Wang, Yu-Hong Li and Rui-Hua Xu
    Citation: BMC Cancer 2019 19:460
    Content type: Research article Published on:

  29. Gastric cancer ranks the fifth most common cancer, and the third leading cause of cancer-related deaths worldwide. Gastric cancer with liver metastasis (GCLM) has devastating prognosis, however, optimal treatm...

    Authors: Qingwei Li, Xuejun Xu, Dan Su, Tianshuo Zhou, Guangyu Wang and Zhiwei Li
    Citation: BMC Cancer 2019 19:459
    Content type: Case report Published on:

  30. Supportive care Prioritization, Assessment and Recommendations for Kids (SPARK) is a web application focused on improving symptom control. It enables pediatric cancer and hematopoietic stem cell transplant (HS...

    Authors: Emily Vettese, Sadie Cook, Dilip Soman, Susan Kuczynski, Brenda Spiegler, Hailey Davis, Nathan Duong, Tal Schechter, L. Lee Dupuis and Lillian Sung
    Citation: BMC Cancer 2019 19:458
    Content type: Research article Published on:

  32. Purpose of this study was to analyze whether preoperative maximum standardized uptake value (SUVmax) and carbohydrate antigen 19–9 (CA19–9) levels might provide prognostic information in Chinese patients with ...

    Authors: Xinjin Gu, Ruiquan Zhou, Chenggang Li, Rong Liu, Zhiming Zhao, Yuanxing Gao and Yong Xu
    Citation: BMC Cancer 2019 19:456
    Content type: Research article Published on:

  33. Wolf-Hirschhorn syndrome candidate gene-1 (WHSC1), a histone methyltransferase, has been found to be upregulated and its expression to be correlated with expression of enhancer of zeste homolog 2 (EZH2) in sev...

    Authors: Machiko Kojima, Kenbun Sone, Katsutoshi Oda, Ryuji Hamamoto, Syuzo Kaneko, Shinya Oki, Asako Kukita, Hidenori Machino, Harunori Honjoh, Yoshiko Kawata, Tomoko Kashiyama, Kayo Asada, Michihiro Tanikawa, Mayuyo Mori-Uchino, Tetsushi Tsuruga, Kazunori Nagasaka…
    Citation: BMC Cancer 2019 19:455
    Content type: Research article Published on:

  34. Major vault protein (MVP) is the major component of vault, a eukaryotic organelle involved in multiple cellular processes, and is important in multiple cellular processes and diseases including the drug resist...

    Authors: Hui Bai, Chenchen Wang, Yu Qi, Jin Xu, Nan Li, Lili Chen, Bin Jiang, Xudong Zhu, Hanwen Zhang, Xiaoyu Li, Qing Yang, Junqing Ma, Yong Xu, Jingjing Ben and Qi Chen
    Citation: BMC Cancer 2019 19:454
    Content type: Research article Published on:

  35. Helicobacter pylori infection is recognized as the main risk factor for gastric cancer (GC), the fifth most common neoplasia worldwide. H. pylori interacts with the immune system, disrupting the cytokine network ...

    Authors: Cecilia Martínez-Campos, Kirvis Torres-Poveda, Margarita Camorlinga-Ponce, Lourdes Flores-Luna, Carmen Maldonado-Bernal, Vicente Madrid-Marina and Javier Torres
    Citation: BMC Cancer 2019 19:453
    Content type: Research article Published on:

  36. Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies and is not a clinically homogeneous disease, but subsets of patients with distinct prognosis and response to therapy can be identi...

    Authors: Maria Cristina Curia, Fabiana Fantini, Rossano Lattanzio, Francesca Tavano, Francesco Di Mola, Mauro Piantelli, Pasquale Battista, Pierluigi Di Sebastiano and Alessandro Cama
    Citation: BMC Cancer 2019 19:452
    Content type: Research article Published on:

  38. The application of circulating, cell-free, methylated Septin9 (mSEPT9) DNA in screening and recurrence monitoring is highly promising. CpG island methylator phenotype (CIMP) is associated with microsatellite inst...

    Authors: Jie Sun, Fei Fei, Mingqing Zhang, Yuwei Li, Xipeng Zhang, Siwei Zhu and Shiwu Zhang
    Citation: BMC Cancer 2019 19:450
    Content type: Research article Published on:

  40. Matrix metalloproteinase 19 (MMP19) is a member of zinc-dependent endopeptidases, which have been involved in various physiological and pathological processes. Its expression has been demonstrated in some type...

    Authors: Zaiping Chen, Guiyang Wu, Fubo Ye, Guoping Chen, Qinghao Fan, Hao Dong, Xiongwen Zhu and Chongshan Wu
    Citation: BMC Cancer 2019 19:448
    Content type: Research article Published on:

  42. TIMP-2 gene plays an important role in the development of breast cancer. The present study was conducted to evaluate whether TIMP-2 gene polymorphisms are associated with breast cancer risk in a Han Chinese cohor...

    Authors: Kai Wang, Guanying Wang, Shangke Huang, Anqi Luo, Xin Jing, Gang Li, Yi Zhou and Xinhan Zhao
    Citation: BMC Cancer 2019 19:446
    Content type: Research article Published on:

  44. Selection of the best lymph node for dissection is a controversial topic in clinical stage-I non-small cell lung cancer (NSCLC). Here, we sought to identify the clinicopathologic predictors of regional lymph n...

    Authors: Fei Zhao, Fu-Xi Zhen, Yue Zhou, Chen-Jun Huang, Yue Yu, Jun Li, Qi-Fan Li, Cheng-Xiang Zhu, Xiao-Yu Yang, Shu-Hui You, Qian-Ge Wu, Xue-Yun Qin, Yi Liu, Liang Chen and Wei Wang
    Citation: BMC Cancer 2019 19:444
    Content type: Research article Published on:

  45. The progress of treatments of childhood acute lymphoblastic leukemia (ALL) has made it possible to reach a survival rate superior to 80%. However, the treatments lead to several long-term adverse effects, incl...

    Authors: Maxime Caru, Kateryna Petrykey, Simon Drouin, Patrick Beaulieu, Pascal St-Onge, Valérie Lemay, Laurence Bertout, Caroline Laverdiere, Gregor Andelfinger, Maja Krajinovic, Daniel Sinnett and Daniel Curnier
    Citation: BMC Cancer 2019 19:443
    Content type: Research article Published on:

  46. Everolimus, an inhibitor of mammalian target of rapamycin (mTOR), has been shown to increase the efficacy of endocrine therapies in hormone receptor (HR)-positive metastatic breast cancer. However, because breast...

    Authors: Zongbi Yi, Fei Ma, Binliang Liu, Xiuwen Guan, Lixi Li, Chunxiao Li, Haili Qian and Binghe Xu
    Citation: BMC Cancer 2019 19:442
    Content type: Research article Published on:

  47. Glioblastoma is a disease with high heterogeneity that has long been difficult for doctors to identify and treat. ARHI is a remarkable tumor suppressor gene in human ovarian cancer and many other cancers. We f...

    Authors: Chen Zhong, Mengting Shu, Junyi Ye, Xiaoxiong Wang, Xin Chen, Zhendong Liu, Wenyang Zhao, Boxian Zhao, Zhixing Zheng, Zhiqin Yin, Ming Gao, Haiqi Zhao, Kaikai Wang and Shiguang Zhao
    Citation: BMC Cancer 2019 19:441
    Content type: Research article Published on:

  48. Palliative pemetrexed-based chemotherapy remains a standard of care treatment for the majority of patients with advanced non-squamous non-small-cell lung cancer (NSCLC). Currently, no predictive markers for pe...

    Authors: S. Visser, J. Hou, K. Bezemer, L. L. de Vogel, J. P. J. J. Hegmans, B. H. Stricker, S. Philipsen and J. G. J. V. Aerts
    Citation: BMC Cancer 2019 19:440
    Content type: Research article Published on:

  49. Dendritic cells (DCs) alter their role from being immunostimulatory to immunosuppressive at advanced stages of tumor progression, but the influence of cancer stem cells (CSCs) and their secreted factors on gen...

    Authors: Ming Zhong, Cheng Zhong, Wen Cui, Guanghui Wang, Gongpu Zheng, Li Li, Jing Zhang, Rujing Ren, Huijei Gao, Tingting Wang, Xin Li, Jiantu Che and Eiichi Gohda
    Citation: BMC Cancer 2019 19:439
    Content type: Research article Published on:

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